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Wyszukujesz frazę ""apoptosis"" wg kryterium: Temat


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Tytuł :
Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) loss in canine mammary carcinoma.
Autorzy :
Kim SH; Department of Veterinary Pathology, Small Animal Diagnostic Center, College of Veterinary Medicine, Konkuk University, Seoul, Republic of Korea.
Seung BJ; Department of Veterinary Pathology, Small Animal Diagnostic Center, College of Veterinary Medicine, Konkuk University, Seoul, Republic of Korea.
Bae MK; Department of Veterinary Pathology, Small Animal Diagnostic Center, College of Veterinary Medicine, Konkuk University, Seoul, Republic of Korea.
Lim HY; Department of Veterinary Pathology, Small Animal Diagnostic Center, College of Veterinary Medicine, Konkuk University, Seoul, Republic of Korea.
Cho SH; Department of Veterinary Pathology, Small Animal Diagnostic Center, College of Veterinary Medicine, Konkuk University, Seoul, Republic of Korea.
Sur JH; Department of Veterinary Pathology, Small Animal Diagnostic Center, College of Veterinary Medicine, Konkuk University, Seoul, Republic of Korea.
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Źródło :
Veterinary and comparative oncology [Vet Comp Oncol] 2022 Mar; Vol. 20 (1), pp. 207-214. Date of Electronic Publication: 2021 Sep 15.
Typ publikacji :
Journal Article
MeSH Terms :
Carcinoma*/veterinary
Dog Diseases*
TNF-Related Apoptosis-Inducing Ligand*
Animals ; Apoptosis/drug effects ; Apoptosis Regulatory Proteins ; Caspase 3 ; Caspases/metabolism ; Dogs ; Ligands ; Membrane Glycoproteins/metabolism ; RNA ; Tumor Necrosis Factor-alpha/metabolism
Czasopismo naukowe
Tytuł :
TRAIL Triggers CRAC-Dependent Calcium Influx and Apoptosis through the Recruitment of Autophagy Proteins to Death-Inducing Signaling Complex.
Autorzy :
Airiau K; Institut Bergonié, INSERM U1218, University of Bordeaux, 33000 Bordeaux, France.
Vacher P; Institut Bergonié, INSERM U1218, University of Bordeaux, 33000 Bordeaux, France.
Micheau O; Lipides, Nutrition Cancer, INSERM, UMR1231, 21079 Dijon, France.; UFR Science de Santé, Université de Bourgogne, Franche-Comté, 21079 Dijon, France.
Prouzet-Mauleon V; Institut Bergonié, INSERM U1218, University of Bordeaux, 33000 Bordeaux, France.
Kroemer G; Centre de Recherche des Cordeliers, INSERM UMRS 1138, Sorbonne Université, Université de Paris, Equipe 11 Labellisée par la Ligue Contre le Cancer, 75006 Paris, France.; Metabolomics and Cell Biology Platforms, Institut Gustave Roussy, 94805 Villejuif, France.; Pôle de Biologie, Hôpital Européen Georges Pompidou, AP-HP, 75015 Paris, France.
Moosavi MA; Department of Molecular Medicine, National Institute of Genetic Engineering and Biotechnology, Tehran P.O. Box 14965/161, Iran.
Djavaheri-Mergny M; Centre de Recherche des Cordeliers, INSERM UMRS 1138, Sorbonne Université, Université de Paris, Equipe 11 Labellisée par la Ligue Contre le Cancer, 75006 Paris, France.; Metabolomics and Cell Biology Platforms, Institut Gustave Roussy, 94805 Villejuif, France.
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Źródło :
Cells [Cells] 2021 Dec 25; Vol. 11 (1). Date of Electronic Publication: 2021 Dec 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis*/drug effects
Autophagy-Related Proteins/*metabolism
Calcium/*metabolism
Calcium Channels/*metabolism
Death Domain Receptor Signaling Adaptor Proteins/*metabolism
TNF-Related Apoptosis-Inducing Ligand/*pharmacology
Cytoprotection/drug effects ; Drug Resistance, Neoplasm/drug effects ; Endoplasmic Reticulum/drug effects ; Endoplasmic Reticulum/metabolism ; Homeostasis/drug effects ; Humans ; Jurkat Cells ; Receptors, TNF-Related Apoptosis-Inducing Ligand/metabolism ; Sequence Analysis, RNA ; Tretinoin/pharmacology
Czasopismo naukowe
Tytuł :
Expression levels of cellular inhibitor of apoptosis proteins and colitogenic cytokines are inversely correlated with the activation of interferon regulatory factor 4.
Autorzy :
Masaki S; Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Osaka-Sayama, Osaka, Japan.
Watanabe T; Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Osaka-Sayama, Osaka, Japan.
Arai Y; Department of Hematology and Oncology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Sekai I; Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Osaka-Sayama, Osaka, Japan.
Hara A; Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Osaka-Sayama, Osaka, Japan.
Kurimoto M; Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Osaka-Sayama, Osaka, Japan.
Otsuka Y; Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Osaka-Sayama, Osaka, Japan.
Masuta Y; Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Osaka-Sayama, Osaka, Japan.
Yoshikawa T; Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Osaka-Sayama, Osaka, Japan.
Takada R; Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Osaka-Sayama, Osaka, Japan.
Kamata K; Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Osaka-Sayama, Osaka, Japan.
Minaga K; Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Osaka-Sayama, Osaka, Japan.
Yamashita K; Department of Hematology and Oncology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Kudo M; Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Osaka-Sayama, Osaka, Japan.
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Źródło :
Clinical and experimental immunology [Clin Exp Immunol] 2022 May 12; Vol. 207 (3), pp. 340-350.
Typ publikacji :
Journal Article
MeSH Terms :
Cytokines*/metabolism
Inhibitor of Apoptosis Proteins*/genetics
Inhibitor of Apoptosis Proteins*/metabolism
Inhibitor of Apoptosis Proteins*/pharmacology
Animals ; Apoptosis ; Humans ; Interferon Regulatory Factors/genetics ; Interferon Regulatory Factors/metabolism ; Ligands ; Mice ; Tumor Necrosis Factor-alpha/metabolism
Czasopismo naukowe
Tytuł :
The combination of TRAIL and the Smac mimetic LCL-161 induces an irreversible phenotypic change of MCF-7 breast cancer cells.
Autorzy :
Granqvist V; Lund University, Translational Cancer Research, Medicon Village, Lund, Sweden.
Holmgren C; Lund University, Translational Cancer Research, Medicon Village, Lund, Sweden.
Larsson C; Lund University, Translational Cancer Research, Medicon Village, Lund, Sweden. Electronic address: .
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Źródło :
Experimental and molecular pathology [Exp Mol Pathol] 2022 Apr; Vol. 125, pp. 104739. Date of Electronic Publication: 2022 Jan 07.
Typ publikacji :
Journal Article
MeSH Terms :
Breast Neoplasms*/drug therapy
Breast Neoplasms*/genetics
Breast Neoplasms*/metabolism
TNF-Related Apoptosis-Inducing Ligand*/metabolism
TNF-Related Apoptosis-Inducing Ligand*/pharmacology
Apoptosis ; Caspases/metabolism ; Caspases/pharmacology ; Cell Line, Tumor ; Female ; Humans ; Inhibitor of Apoptosis Proteins ; MCF-7 Cells ; NF-kappa B/genetics ; NF-kappa B/metabolism ; Neoplasm Recurrence, Local ; Phenotype
Czasopismo naukowe
Tytuł :
Functional Genomic Identification of Predictors of Sensitivity and Mechanisms of Resistance to Multivalent Second-Generation TRAIL-R2 Agonists.
Autorzy :
Grinkevitch V; Wellcome Sanger Institute, Hinxton, Cambridge, United Kingdom.
Wappett M; Patrick G. Johnston Centre for Cancer Research, Queen's University, Belfast, United Kingdom.
Crawford N; Patrick G. Johnston Centre for Cancer Research, Queen's University, Belfast, United Kingdom.
Price S; Wellcome Sanger Institute, Hinxton, Cambridge, United Kingdom.
Lees A; Patrick G. Johnston Centre for Cancer Research, Queen's University, Belfast, United Kingdom.
McCann C; Patrick G. Johnston Centre for Cancer Research, Queen's University, Belfast, United Kingdom.
McAllister K; Patrick G. Johnston Centre for Cancer Research, Queen's University, Belfast, United Kingdom.
Prehn J; Royal College of Surgeons Ireland, Dublin, Ireland.
Young J; Wellcome Sanger Institute, Hinxton, Cambridge, United Kingdom.
Bateson J; Wellcome Sanger Institute, Hinxton, Cambridge, United Kingdom.
Gallagher L; Wellcome Sanger Institute, Hinxton, Cambridge, United Kingdom.
Michaut M; Division of Molecular Carcinogenesis, The Netherlands Cancer Institute, Amsterdam, the Netherlands.
Iyer V; Wellcome Sanger Institute, Hinxton, Cambridge, United Kingdom.
Chatzipli A; Wellcome Sanger Institute, Hinxton, Cambridge, United Kingdom.
Barthorpe S; Wellcome Sanger Institute, Hinxton, Cambridge, United Kingdom.
Ciznadija D; Champions Oncology Inc., Rockville, Maryland.
Sloma I; Champions Oncology Inc., Rockville, Maryland.
Wesa A; Champions Oncology Inc., Rockville, Maryland.
Tice DA; Oncology R&D, AstraZeneca, Gaithersburg, Maryland.
Wessels L; Division of Molecular Carcinogenesis, The Netherlands Cancer Institute, Amsterdam, the Netherlands.; Delft Bioinformatics Lab, TU Delft, Delft, the Netherlands.
Garnett M; Wellcome Sanger Institute, Hinxton, Cambridge, United Kingdom.
Longley DB; Patrick G. Johnston Centre for Cancer Research, Queen's University, Belfast, United Kingdom.
McDermott U; Wellcome Sanger Institute, Hinxton, Cambridge, United Kingdom.
McDade SS; Patrick G. Johnston Centre for Cancer Research, Queen's University, Belfast, United Kingdom.
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Źródło :
Molecular cancer therapeutics [Mol Cancer Ther] 2022 Apr 01; Vol. 21 (4), pp. 594-606.
Typ publikacji :
Journal Article
MeSH Terms :
Proto-Oncogene Proteins c-bcl-2*/metabolism
TNF-Related Apoptosis-Inducing Ligand*/metabolism
TNF-Related Apoptosis-Inducing Ligand*/pharmacology
Apoptosis ; CASP8 and FADD-Like Apoptosis Regulating Protein/genetics ; CASP8 and FADD-Like Apoptosis Regulating Protein/metabolism ; Caspase 8/genetics ; Cell Line, Tumor ; Genomics ; Humans
Czasopismo naukowe
Tytuł :
Targeting the apoptosis pathway to treat tumours of the paediatric nervous system.
Autorzy :
Fitzgerald MC; Department of Physiology & Medical Physics, Royal College of Surgeons in Ireland, 31A York Street, Dublin, D02 YN77, Ireland.; National Children's Research Centre at Children's Health Ireland at Crumlin, Dublin, D12 N512, Ireland.
O'Halloran PJ; National Children's Research Centre at Children's Health Ireland at Crumlin, Dublin, D12 N512, Ireland.; Department of Neurosurgery, Queen Elizabeth Hospital, Birmingham, UK.
Connolly NMC; Department of Physiology & Medical Physics, Royal College of Surgeons in Ireland, 31A York Street, Dublin, D02 YN77, Ireland.; Centre for Systems Medicine, Royal College of Surgeons in Ireland, 31A York Street, Dublin, D02 YN77, Ireland.
Murphy BM; Department of Physiology & Medical Physics, Royal College of Surgeons in Ireland, 31A York Street, Dublin, D02 YN77, Ireland. .; National Children's Research Centre at Children's Health Ireland at Crumlin, Dublin, D12 N512, Ireland. .; Centre for Systems Medicine, Royal College of Surgeons in Ireland, 31A York Street, Dublin, D02 YN77, Ireland. .
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Źródło :
Cell death & disease [Cell Death Dis] 2022 May 14; Vol. 13 (5), pp. 460. Date of Electronic Publication: 2022 May 14.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Neoplasms*/drug therapy
Neoplasms*/genetics
Neoplasms*/pathology
TNF-Related Apoptosis-Inducing Ligand*/pharmacology
Apoptosis ; Child ; Humans ; Nervous System/metabolism ; Receptors, TNF-Related Apoptosis-Inducing Ligand/metabolism
Czasopismo naukowe
Tytuł :
Understanding of cell death induced by the constituents of Taxus yunnanensis wood.
Autorzy :
Akao Y; United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, 1-1 Yanagido, Gifu, Japan. .
Terazawa R; United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, 1-1 Yanagido, Gifu, Japan.
Sugito N; United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, 1-1 Yanagido, Gifu, Japan.
Heishima K; United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, 1-1 Yanagido, Gifu, Japan.
Morikawa K; United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, 1-1 Yanagido, Gifu, Japan.
Ito Y; Department of General and Gastroenterological Surgery, Osaka Medical and Pharmaceutical University, Takatsuki, Japan.
Narui R; Karasuma Wada Clinic, Nakagyo-ku, Kyoto, 604-0845, Japan.
Hamaguchi R; Karasuma Wada Clinic, Nakagyo-ku, Kyoto, 604-0845, Japan.
Nobukawa T; Kotosugi Co., Ltd, Sagamihara, Japan.
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Źródło :
Scientific reports [Sci Rep] 2022 Apr 15; Vol. 12 (1), pp. 6282. Date of Electronic Publication: 2022 Apr 15.
Typ publikacji :
Journal Article
MeSH Terms :
Receptors, TNF-Related Apoptosis-Inducing Ligand*/metabolism
Taxus*/metabolism
Animals ; Apoptosis ; Cell Death ; Cell Line, Tumor ; Membrane Glycoproteins/metabolism ; Mice ; Plant Extracts/pharmacology ; TNF-Related Apoptosis-Inducing Ligand/pharmacology ; Wood/metabolism
Czasopismo naukowe
Tytuł :
Lipid Phase Separation in Vesicles Enhances TRAIL-Mediated Cytotoxicity.
Autorzy :
Vu TQ; Department of Biomedical Engineering, McCormick School of Engineering, Northwestern University, Evanston, Illinois 60208, United States.
Peruzzi JA; Department of Chemical and Biological Engineering, McCormick School of Engineering, Northwestern University, Evanston, Illinois 60208, United States.
Sant'Anna LE; Department of Biomedical Engineering, McCormick School of Engineering, Northwestern University, Evanston, Illinois 60208, United States.
Roth EW; Northwestern University Atomic and Nanoscale Characterization and Experimentation Center, Northwestern University, Evanston, Illinois 60208, United States.
Kamat NP; Department of Biomedical Engineering, McCormick School of Engineering, Northwestern University, Evanston, Illinois 60208, United States.; Center for Synthetic Biology, McCormick School of Engineering, Northwestern University, Evanston, Illinois 60208, United States.
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Źródło :
Nano letters [Nano Lett] 2022 Apr 13; Vol. 22 (7), pp. 2627-2634. Date of Electronic Publication: 2022 Mar 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, N.I.H., Extramural
MeSH Terms :
Receptors, TNF-Related Apoptosis-Inducing Ligand*/metabolism
TNF-Related Apoptosis-Inducing Ligand*/pharmacology
Apoptosis ; Cell Line, Tumor ; Humans ; Ligands ; Lipids
Czasopismo naukowe
Tytuł :
MicroRNA regulation of BAG3.
Autorzy :
Singh MV; Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA.
Dhanabalan K; Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA.
Verry J; Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA.
Dokun AO; Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA.
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Źródło :
Experimental biology and medicine (Maywood, N.J.) [Exp Biol Med (Maywood)] 2022 Apr; Vol. 247 (8), pp. 617-623. Date of Electronic Publication: 2022 Jan 15.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Apoptosis Regulatory Proteins*/genetics
Apoptosis Regulatory Proteins*/metabolism
MicroRNAs*/genetics
Adaptor Proteins, Signal Transducing/genetics ; Adaptor Proteins, Signal Transducing/metabolism ; Apoptosis ; Autophagy/genetics
Czasopismo naukowe
Tytuł :
CDK4/6 Inhibition Suppresses p73 Phosphorylation and Activates DR5 to Potentiate Chemotherapy and Immune Checkpoint Blockade.
Autorzy :
Tong J; UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania.; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Tan X; UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania.; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Song X; UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania.; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Gao M; UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania.; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Risnik D; UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania.; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Hao S; UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania.; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Ermine K; UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania.; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Wang P; UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania.; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Li H; UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania.; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Huang Y; UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania.; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Yu J; UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania.; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Zhang L; UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania.; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
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Źródło :
Cancer research [Cancer Res] 2022 Apr 01; Vol. 82 (7), pp. 1340-1352.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Cyclin-Dependent Kinase 4*/antagonists & inhibitors
Cyclin-Dependent Kinase 6*/antagonists & inhibitors
Immune Checkpoint Inhibitors*
Receptors, TNF-Related Apoptosis-Inducing Ligand*/metabolism
TNF-Related Apoptosis-Inducing Ligand*/pharmacology
Tumor Protein p73*/metabolism
Apoptosis ; Cell Line, Tumor ; Fluorouracil/pharmacology ; Humans ; Phosphorylation
Czasopismo naukowe
Tytuł :
N resonance assignments of the first BIR domain of cellular inhibitor of apoptosis protein 1.
Autorzy :
Ng HQ; Experimental Drug Development Centre (EDDC), Agency for Science, Technology and Research (A*STAR), Singapore, 138670, Singapore.
Li Q; Guangdong Provincial Engineering Laboratory of Biomass High Value Utilization, Institute of Biological and Medical Engineering, Guangdong Academy of Sciences, Guangzhou, 510316, China.
Kang C; Experimental Drug Development Centre (EDDC), Agency for Science, Technology and Research (A*STAR), Singapore, 138670, Singapore. .
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Źródło :
Biomolecular NMR assignments [Biomol NMR Assign] 2022 Apr; Vol. 16 (1), pp. 91-95. Date of Electronic Publication: 2022 Jan 21.
Typ publikacji :
Journal Article
MeSH Terms :
Baculoviridae*/metabolism
Inhibitor of Apoptosis Proteins*/chemistry
Inhibitor of Apoptosis Proteins*/metabolism
Apoptosis/physiology ; Baculoviral IAP Repeat-Containing 3 Protein/metabolism ; Caspases/metabolism ; Cell Line ; Humans ; Nuclear Magnetic Resonance, Biomolecular ; Protein Binding
Czasopismo naukowe
Tytuł :
Regulation of extrinsic apoptotic signaling by c-FLIP: towards targeting cancer networks.
Autorzy :
Ivanisenko NV; The Federal Research Center Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; Artificial Intelligence Research Institute, Moscow, Russia.
Seyrek K; Translational Inflammation Research, Medical Faculty, Otto von Guericke University Magdeburg, 39106 Magdeburg, Germany.
Hillert-Richter LK; Translational Inflammation Research, Medical Faculty, Otto von Guericke University Magdeburg, 39106 Magdeburg, Germany.
König C; Translational Inflammation Research, Medical Faculty, Otto von Guericke University Magdeburg, 39106 Magdeburg, Germany.
Espe J; Translational Inflammation Research, Medical Faculty, Otto von Guericke University Magdeburg, 39106 Magdeburg, Germany.
Bose K; Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre, Kharghar, Navi Mumbai 410210, India; Homi Bhabha National Institute, BARC Training School Complex, Anushaktinagar, Mumbai 400094, India.
Lavrik IN; The Federal Research Center Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; Translational Inflammation Research, Medical Faculty, Otto von Guericke University Magdeburg, 39106 Magdeburg, Germany. Electronic address: .
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Źródło :
Trends in cancer [Trends Cancer] 2022 Mar; Vol. 8 (3), pp. 190-209. Date of Electronic Publication: 2021 Dec 29.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
CASP8 and FADD-Like Apoptosis Regulating Protein*/genetics
CASP8 and FADD-Like Apoptosis Regulating Protein*/metabolism
Neoplasms*/drug therapy
Neoplasms*/genetics
Apoptosis/physiology ; Humans ; Signal Transduction ; fas Receptor/genetics ; fas Receptor/metabolism
Czasopismo naukowe
Tytuł :
Silencing of Mcl-1 overcomes resistance of melanoma cells against TRAIL-armed oncolytic adenovirus by enhancement of apoptosis.
Autorzy :
Tolksdorf B; Department of Applied Biochemistry, Institute of Biotechnology, Technische Universität Berlin, Gustav-Meyer-Allee 25, 15533, Berlin, Germany.
Zarif S; Department of Dermatology, Venerology and Allergology, Skin Cancer Center Charité, Charité-Universitätsmedizin Berlin (University Medical Center Charité), 10117, Berlin, Germany.
Eberle J; Department of Dermatology, Venerology and Allergology, Skin Cancer Center Charité, Charité-Universitätsmedizin Berlin (University Medical Center Charité), 10117, Berlin, Germany.
Hazini A; Department of Applied Biochemistry, Institute of Biotechnology, Technische Universität Berlin, Gustav-Meyer-Allee 25, 15533, Berlin, Germany.
Dieringer B; Department of Applied Biochemistry, Institute of Biotechnology, Technische Universität Berlin, Gustav-Meyer-Allee 25, 15533, Berlin, Germany.
Jönsson F; Faculty of Health, School of Medicine, Center for Biomedical Research and Education ZBAF, Witten/Herdecke University, Stockumer Straße 10, 58453, Witten, Germany.
Kreppel F; Faculty of Health, School of Medicine, Center for Biomedical Research and Education ZBAF, Witten/Herdecke University, Stockumer Straße 10, 58453, Witten, Germany.
Kurreck J; Department of Applied Biochemistry, Institute of Biotechnology, Technische Universität Berlin, Gustav-Meyer-Allee 25, 15533, Berlin, Germany.
Fechner H; Department of Applied Biochemistry, Institute of Biotechnology, Technische Universität Berlin, Gustav-Meyer-Allee 25, 15533, Berlin, Germany. .
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Źródło :
Journal of molecular medicine (Berlin, Germany) [J Mol Med (Berl)] 2021 Sep; Vol. 99 (9), pp. 1279-1291. Date of Electronic Publication: 2021 May 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis*
Gene Silencing*
Genetic Therapy*
Oncolytic Virotherapy*
Adenoviridae/*genetics
Melanoma/*therapy
Myeloid Cell Leukemia Sequence 1 Protein/*genetics
Oncolytic Viruses/*genetics
Skin Neoplasms/*therapy
TNF-Related Apoptosis-Inducing Ligand/*genetics
Adenoviridae/metabolism ; Apoptosis Regulatory Proteins/genetics ; Apoptosis Regulatory Proteins/metabolism ; Cell Line, Tumor ; Gene Expression Regulation, Neoplastic ; Humans ; Melanoma/genetics ; Melanoma/metabolism ; Melanoma/virology ; Myeloid Cell Leukemia Sequence 1 Protein/metabolism ; Necrosis ; Oncolytic Viruses/metabolism ; Skin Neoplasms/genetics ; Skin Neoplasms/metabolism ; Skin Neoplasms/virology ; TNF-Related Apoptosis-Inducing Ligand/metabolism
Czasopismo naukowe
Tytuł :
Roles of the pro-apoptotic factors CaNma111 and CaYbh3 in apoptosis and virulence of Candida albicans.
Autorzy :
Nam M; Department of Microbiology and Molecular Biology, College of Bioscience and Biotechnology, Chungnam National University, 99 Daehak-ro, Yuseong-gu, Daejeon, 34134, Republic of Korea.
Kim SH; Department of Microbiology and Molecular Biology, College of Bioscience and Biotechnology, Chungnam National University, 99 Daehak-ro, Yuseong-gu, Daejeon, 34134, Republic of Korea.
Jeong JH; Department of Microbiology and Molecular Biology, College of Bioscience and Biotechnology, Chungnam National University, 99 Daehak-ro, Yuseong-gu, Daejeon, 34134, Republic of Korea.
Kim S; Department of Microbiology and Molecular Biology, College of Bioscience and Biotechnology, Chungnam National University, 99 Daehak-ro, Yuseong-gu, Daejeon, 34134, Republic of Korea.
Kim J; Department of Microbiology and Molecular Biology, College of Bioscience and Biotechnology, Chungnam National University, 99 Daehak-ro, Yuseong-gu, Daejeon, 34134, Republic of Korea. .
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Źródło :
Scientific reports [Sci Rep] 2022 May 09; Vol. 12 (1), pp. 7574. Date of Electronic Publication: 2022 May 09.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis*
Candida albicans*/metabolism
Animals ; Antifungal Agents/metabolism ; Antifungal Agents/pharmacology ; Inhibitor of Apoptosis Proteins/metabolism ; Mammals ; Mice ; Virulence
Czasopismo naukowe
Tytuł :
Efficacy and specificity of inhibitors of BCL-2 family protein interactions assessed by affinity measurements in live cells.
Autorzy :
Osterlund EJ; Biological Sciences, Sunnybrook Research Institute, Toronto, Ontario M4N 3M5, Canada.; Department of Biochemistry, University of Toronto, Toronto, Ontario M5S 2J7, Canada.
Hirmiz N; Biological Sciences, Sunnybrook Research Institute, Toronto, Ontario M4N 3M5, Canada.; School of Biomedical Engineering, McMaster University, Hamilton, Ontario L8S 4L7, Canada.
Pemberton JM; Biological Sciences, Sunnybrook Research Institute, Toronto, Ontario M4N 3M5, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5S 2J7, Canada.
Nougarède A; Biological Sciences, Sunnybrook Research Institute, Toronto, Ontario M4N 3M5, Canada.
Liu Q; Biological Sciences, Sunnybrook Research Institute, Toronto, Ontario M4N 3M5, Canada.
Leber B; Department of Medicine, McMaster University, Hamilton, Ontario L8N 3Z5, Canada.
Fang Q; School of Biomedical Engineering, McMaster University, Hamilton, Ontario L8S 4L7, Canada.; Department of Engineering Physics, McMaster University, 1280 Main Street West, Hamilton, Ontario L8S 4L7, Canada.
Andrews DW; Biological Sciences, Sunnybrook Research Institute, Toronto, Ontario M4N 3M5, Canada.; Department of Biochemistry, University of Toronto, Toronto, Ontario M5S 2J7, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5S 2J7, Canada.
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Źródło :
Science advances [Sci Adv] 2022 Apr 22; Vol. 8 (16), pp. eabm7375. Date of Electronic Publication: 2022 Apr 20.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis Regulatory Proteins*/metabolism
Proto-Oncogene Proteins*/metabolism
Apoptosis ; Proto-Oncogene Proteins c-bcl-2/metabolism
Czasopismo naukowe
Tytuł :
An atlas of inter- and intra-tumor heterogeneity of apoptosis competency in colorectal cancer tissue at single-cell resolution.
Autorzy :
Lindner AU; Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland University of Medicine and Health Sciences, 123 St. Stephen's Green, Dublin 2, Ireland.; Centre of Systems Medicine, Royal College of Surgeons in Ireland University of Medicine and Health Sciences, 123 St. Stephen's Green, Dublin 2, Ireland.
Salvucci M; Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland University of Medicine and Health Sciences, 123 St. Stephen's Green, Dublin 2, Ireland.; Centre of Systems Medicine, Royal College of Surgeons in Ireland University of Medicine and Health Sciences, 123 St. Stephen's Green, Dublin 2, Ireland.
McDonough E; GE Research, Niskayuna, NY, 12309, USA.
Cho S; GE Research, Niskayuna, NY, 12309, USA.
Stachtea X; Centre for Cancer Research & Cell Biology, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7AE, Northern Ireland, UK.
O'Connell EP; Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland University of Medicine and Health Sciences, 123 St. Stephen's Green, Dublin 2, Ireland.; Centre of Systems Medicine, Royal College of Surgeons in Ireland University of Medicine and Health Sciences, 123 St. Stephen's Green, Dublin 2, Ireland.; Department of Surgery, Royal College of Surgeons in Ireland University of Medicine and Health Sciences, 123 St. Stephen's Green, Dublin 2, Ireland.
Corwin AD; GE Research, Niskayuna, NY, 12309, USA.
Santamaria-Pang A; GE Research, Niskayuna, NY, 12309, USA.
Carberry S; Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland University of Medicine and Health Sciences, 123 St. Stephen's Green, Dublin 2, Ireland.; Centre of Systems Medicine, Royal College of Surgeons in Ireland University of Medicine and Health Sciences, 123 St. Stephen's Green, Dublin 2, Ireland.
Fichtner M; Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland University of Medicine and Health Sciences, 123 St. Stephen's Green, Dublin 2, Ireland.; Centre of Systems Medicine, Royal College of Surgeons in Ireland University of Medicine and Health Sciences, 123 St. Stephen's Green, Dublin 2, Ireland.
Van Schaeybroeck S; Centre for Cancer Research & Cell Biology, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7AE, Northern Ireland, UK.
Laurent-Puig P; Centre de Recherche des Cordeliers, INSERM, CNRS, Université de Paris, Sorbonne Université, USPC, Equipe labellisée Ligue Nationale Contre le Cancer, Paris, France.
Burke JP; Department of Surgery, Royal College of Surgeons in Ireland University of Medicine and Health Sciences, 123 St. Stephen's Green, Dublin 2, Ireland.
McNamara DA; Department of Surgery, Royal College of Surgeons in Ireland University of Medicine and Health Sciences, 123 St. Stephen's Green, Dublin 2, Ireland.; Beaumont Hospital, Beaumont Road, Dublin 9, Ireland.
Lawler M; Centre for Cancer Research & Cell Biology, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7AE, Northern Ireland, UK.
Sood A; GE Research, Niskayuna, NY, 12309, USA.
Graf JF; GE Research, Niskayuna, NY, 12309, USA.
Rehm M; Institute of Cell Biology and Immunology, University of Stuttgart, Allmandring 31, 70569, Stuttgart, Germany.
Dunne PD; Centre for Cancer Research & Cell Biology, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7AE, Northern Ireland, UK.
Longley DB; Centre for Cancer Research & Cell Biology, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7AE, Northern Ireland, UK.
Ginty F; GE Research, Niskayuna, NY, 12309, USA.
Prehn JHM; Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland University of Medicine and Health Sciences, 123 St. Stephen's Green, Dublin 2, Ireland. .; Centre of Systems Medicine, Royal College of Surgeons in Ireland University of Medicine and Health Sciences, 123 St. Stephen's Green, Dublin 2, Ireland. .
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Źródło :
Cell death and differentiation [Cell Death Differ] 2022 Apr; Vol. 29 (4), pp. 806-817. Date of Electronic Publication: 2021 Nov 09.
Typ publikacji :
Journal Article
MeSH Terms :
Colorectal Neoplasms*/metabolism
X-Linked Inhibitor of Apoptosis Protein*/metabolism
Apoptosis/physiology ; Humans ; Mitochondria/metabolism ; Mitochondrial Proteins/metabolism
Czasopismo naukowe
Tytuł :
Human B Cells Mediate Innate Anti-Cancer Cytotoxicity Through Concurrent Engagement of Multiple TNF Superfamily Ligands.
Autorzy :
Janjic BM; UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, United States.
Kulkarni A; UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, United States.; Department of Otolaryngology, University of Pittsburgh, Pittsburgh, PA, United States.
Ferris RL; UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, United States.; Department of Otolaryngology, University of Pittsburgh, Pittsburgh, PA, United States.; Department of Immunology, University of Pittsburgh, Pittsburgh, PA, United States.
Vujanovic L; UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, United States.; Department of Otolaryngology, University of Pittsburgh, Pittsburgh, PA, United States.
Vujanovic NL; UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, United States.; Department of Pathology, University of Pittsburgh, Pittsburgh, PA, United States.
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Źródło :
Frontiers in immunology [Front Immunol] 2022 Mar 22; Vol. 13, pp. 837842. Date of Electronic Publication: 2022 Mar 22 (Print Publication: 2022).
Typ publikacji :
Journal Article
MeSH Terms :
Neoplasms*
TNF-Related Apoptosis-Inducing Ligand*
Apoptosis Regulatory Proteins ; Humans ; Ligands ; Tumor Necrosis Factor-alpha/metabolism
Czasopismo naukowe
Tytuł :
Silencing ESRP1 expression promotes caspase-independent cell death via nuclear translocation of AIF in colon cancer cells.
Autorzy :
Vadlamudi Y; Department of Biotechnology, Daegu University, Gyeongsan, Gyeongbuk 38453, Republic of Korea.
Kang SC; Department of Biotechnology, Daegu University, Gyeongsan, Gyeongbuk 38453, Republic of Korea. Electronic address: .
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Źródło :
Cellular signalling [Cell Signal] 2022 Mar; Vol. 91, pp. 110237. Date of Electronic Publication: 2022 Jan 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis Inducing Factor*/metabolism
Colonic Neoplasms*/genetics
RNA-Binding Proteins*/genetics
RNA-Binding Proteins*/metabolism
Apoptosis ; Caspases/metabolism ; Cell Line, Tumor ; Humans ; Proteomics
Czasopismo naukowe
Tytuł :
SMAC Mimetics as Therapeutic Agents in HIV Infection.
Autorzy :
Molyer B; Chronic Disease Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada.
Kumar A; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada.; Apoptosis Research Center of Children's Hospital of Eastern Ontario, Department of Microbiology and Immunology, University of Ottawa, Ottawa, Canada.
Angel JB; Chronic Disease Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada.; Division of Infectious Diseases, Ottawa Hospital, Ottawa, ON, Canada.
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Źródło :
Frontiers in immunology [Front Immunol] 2021 Nov 26; Vol. 12, pp. 780400. Date of Electronic Publication: 2021 Nov 26 (Print Publication: 2021).
Typ publikacji :
Journal Article; Review
MeSH Terms :
Apoptosis Regulatory Proteins*
Mitochondrial Proteins*
Apoptosis/*drug effects
Biomimetic Materials/*therapeutic use
HIV Infections/*drug therapy
Virus Latency/*drug effects
Animals ; Humans ; Inhibitor of Apoptosis Proteins/antagonists & inhibitors ; Latent Infection/drug therapy
Czasopismo naukowe
Tytuł :
The deubiquitinase Usp27x as a novel regulator of cFLIP L protein expression and sensitizer to death-receptor-induced apoptosis.
Autorzy :
Dold MN; Faculty of Medicine, Institute of Medical Microbiology and Hygiene, Medical Center, University of Freiburg, Freiburg, Germany.
Ng X; Faculty of Medicine, Institute of Medical Microbiology and Hygiene, Medical Center, University of Freiburg, Freiburg, Germany.
Alber C; Faculty of Medicine, Institute of Medical Microbiology and Hygiene, Medical Center, University of Freiburg, Freiburg, Germany.
Gentle IE; Faculty of Medicine, Institute of Medical Microbiology and Hygiene, Medical Center, University of Freiburg, Freiburg, Germany.
Häcker G; Faculty of Medicine, Institute of Medical Microbiology and Hygiene, Medical Center, University of Freiburg, Freiburg, Germany.; BIOSS Centre for Biological Signalling Studies, University of Freiburg, Freiburg, Germany.
Weber A; Faculty of Medicine, Institute of Medical Microbiology and Hygiene, Medical Center, University of Freiburg, Freiburg, Germany. .
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Źródło :
Apoptosis : an international journal on programmed cell death [Apoptosis] 2022 Feb; Vol. 27 (1-2), pp. 112-132. Date of Electronic Publication: 2022 Jan 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis*/genetics
Ubiquitin-Specific Proteases*/metabolism
Apoptosis Regulatory Proteins/metabolism ; CASP8 and FADD-Like Apoptosis Regulating Protein/genetics ; CASP8 and FADD-Like Apoptosis Regulating Protein/metabolism ; Humans ; Ubiquitin-Protein Ligases/metabolism ; Ubiquitination
Czasopismo naukowe

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