Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

Przeglądasz jako GOŚĆ

Wyszukujesz frazę ""astrocytes"" wg kryterium: Temat


Tytuł :
Brain astrocytes and microglia express functional MR1 molecules that present microbial antigens to mucosal-associated invariant T (MAIT) cells.
Autorzy :
Priya R; Department of Microbiology and Immunology, Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202, United States. Electronic address: .
Brutkiewicz RR; Department of Microbiology and Immunology, Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202, United States. Electronic address: .
Pokaż więcej
Źródło :
Journal of neuroimmunology [J Neuroimmunol] 2020 Dec 15; Vol. 349, pp. 577428. Date of Electronic Publication: 2020 Oct 15.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Astrocytes/*metabolism
Brain/*metabolism
Histocompatibility Antigens Class I/*biosynthesis
Immunity, Innate/*physiology
Microglia/*metabolism
Minor Histocompatibility Antigens/*biosynthesis
Mucosal-Associated Invariant T Cells/*metabolism
Animals ; Astrocytes/immunology ; Brain/immunology ; Cell Line ; Female ; Histocompatibility Antigens Class I/immunology ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Microglia/immunology ; Minor Histocompatibility Antigens/immunology ; Mucosal-Associated Invariant T Cells/immunology
Czasopismo naukowe
Tytuł :
Presence of Titanium and Toxic Effects Observed in Rat Lungs, Kidneys, and Central Nervous System in vivo and in Cultured Astrocytes in vitro on Exposure by Titanium Dioxide Nanorods.
Autorzy :
Papp A; Department of Public Health, Faculty of Medicine, University of Szeged, Szeged, Hungary.
Horváth T; Department of Public Health, Faculty of Medicine, University of Szeged, Szeged, Hungary.
Igaz N; Department of Biochemistry and Molecular Biology, Faculty of Science and Informatics, University of Szeged, Szeged, Hungary.
Gopisetty MK; Department of Biochemistry and Molecular Biology, Faculty of Science and Informatics, University of Szeged, Szeged, Hungary.
Kiricsi M; Department of Biochemistry and Molecular Biology, Faculty of Science and Informatics, University of Szeged, Szeged, Hungary.
Berkesi DS; Department of Applied and Environmental Chemistry, Faculty of Science and Informatics, University of Szeged, Szeged, Hungary.
Kozma G; Department of Applied and Environmental Chemistry, Faculty of Science and Informatics, University of Szeged, Szeged, Hungary.
Kónya Z; Department of Applied and Environmental Chemistry, Faculty of Science and Informatics, University of Szeged, Szeged, Hungary.
Wilhelm I; Institute of Biophysics, Biological Research Centre, Szeged, Szeged, Hungary.
Patai R; Institute of Biophysics, Biological Research Centre, Szeged, Szeged, Hungary.
Polgár TF; Institute of Biophysics, Biological Research Centre, Szeged, Szeged, Hungary.
Bellák T; Department of Anatomy, Histology and Embryology, Faculty of Medicine, University of Szeged, Szeged, Hungary.
Tiszlavicz L; Department of Pathology, Faculty of Medicine, University of Szeged, Szeged, Hungary.
Razga Z; Department of Pathology, Faculty of Medicine, University of Szeged, Szeged, Hungary.
Vezér T; Department of Public Health, Faculty of Medicine, University of Szeged, Szeged, Hungary.
Pokaż więcej
Źródło :
International journal of nanomedicine [Int J Nanomedicine] 2020 Dec 08; Vol. 15, pp. 9939-9960. Date of Electronic Publication: 2020 Dec 08 (Print Publication: 2020).
Typ publikacji :
Journal Article
MeSH Terms :
Astrocytes/*drug effects
Central Nervous System/*drug effects
Kidney/*drug effects
Lung/*drug effects
Nanotubes/*chemistry
Titanium/*chemistry
Titanium/*toxicity
Animals ; Apoptosis/drug effects ; Astrocytes/cytology ; Astrocytes/metabolism ; Cells, Cultured ; Central Nervous System/metabolism ; Humans ; Kidney/metabolism ; Lung/metabolism ; Oxidative Stress/drug effects ; Rats ; Rats, Wistar
Czasopismo naukowe
Tytuł :
E-cigarette aerosols containing nicotine modulate nicotinic acetylcholine receptors and astroglial glutamate transporters in mesocorticolimbic brain regions of chronically exposed mice.
Autorzy :
Alasmari F; Department of Pharmacology and Experimental Therapeutics, College of Pharmacy and Pharmaceutical Sciences, The University of Toledo, Toledo, OH, 43614, USA; Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Crotty Alexander LE; Pulmonary and Critical Care Section, VA San Diego Healthcare System, 3350 La Jolla Village Dr, MC 111J, San Diego, CA, 92161, USA; Department of Medicine, Division of Pulmonary and Critical Care, University of California at San Diego (UCSD), La Jolla, CA, 92093, USA.
Hammad AM; Department of Pharmacology and Experimental Therapeutics, College of Pharmacy and Pharmaceutical Sciences, The University of Toledo, Toledo, OH, 43614, USA; Department of Pharmacy, College of Pharmacy, Al-Zaytoonah University of Jordan, Amman, Jordan.
Horton A; Department of Medicinal and Biological Chemistry, College of Pharmacy and Pharmaceutical Sciences, The University of Toledo, Toledo, OH, 43614, USA.
Alhaddad H; Department of Pharmacology and Experimental Therapeutics, College of Pharmacy and Pharmaceutical Sciences, The University of Toledo, Toledo, OH, 43614, USA.
Schiefer IT; Department of Medicinal and Biological Chemistry, College of Pharmacy and Pharmaceutical Sciences, The University of Toledo, Toledo, OH, 43614, USA.
Shin J; Pulmonary and Critical Care Section, VA San Diego Healthcare System, 3350 La Jolla Village Dr, MC 111J, San Diego, CA, 92161, USA; Department of Medicine, Division of Pulmonary and Critical Care, University of California at San Diego (UCSD), La Jolla, CA, 92093, USA.
Moshensky A; Pulmonary and Critical Care Section, VA San Diego Healthcare System, 3350 La Jolla Village Dr, MC 111J, San Diego, CA, 92161, USA; Department of Medicine, Division of Pulmonary and Critical Care, University of California at San Diego (UCSD), La Jolla, CA, 92093, USA.
Sari Y; Department of Pharmacology and Experimental Therapeutics, College of Pharmacy and Pharmaceutical Sciences, The University of Toledo, Toledo, OH, 43614, USA. Electronic address: .
Pokaż więcej
Źródło :
Chemico-biological interactions [Chem Biol Interact] 2021 Jan 05; Vol. 333, pp. 109308. Date of Electronic Publication: 2020 Nov 23.
Typ publikacji :
Journal Article
MeSH Terms :
Electronic Nicotine Delivery Systems*
Astrocytes/*metabolism
Brain/*drug effects
Nicotine/*adverse effects
Receptors, Nicotinic/*metabolism
Vesicular Glutamate Transport Proteins/*metabolism
Aerosols ; Animals ; Astrocytes/drug effects ; Brain/metabolism ; Brain-Derived Neurotrophic Factor/metabolism ; Cytoskeletal Proteins/metabolism ; Gene Expression Regulation/drug effects ; Mice ; Mice, Inbred C57BL ; Nerve Tissue Proteins/metabolism ; Time Factors
Czasopismo naukowe
Tytuł :
Filamentous recombinant human Tau activates primary astrocytes via an integrin receptor complex.
Autorzy :
Wang P; Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, 20892, USA.
Ye Y; Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, 20892, USA. .
Pokaż więcej
Źródło :
Nature communications [Nat Commun] 2021 Jan 04; Vol. 12 (1), pp. 95. Date of Electronic Publication: 2021 Jan 04.
Typ publikacji :
Journal Article; Research Support, N.I.H., Intramural
MeSH Terms :
Astrocytes/*metabolism
Receptors, Vitronectin/*metabolism
Recombinant Proteins/*metabolism
tau Proteins/*metabolism
Animals ; Astrocytes/pathology ; Cells, Cultured ; Focal Adhesion Protein-Tyrosine Kinases/metabolism ; HEK293 Cells ; Heparan Sulfate Proteoglycans/metabolism ; Humans ; Inflammation/pathology ; Mice, Inbred C57BL ; NF-kappa B/metabolism ; Neurons/metabolism ; Neurons/pathology ; Protein Binding ; STAT3 Transcription Factor/metabolism ; Signal Transduction ; Talin/metabolism ; tau Proteins/ultrastructure
Czasopismo naukowe
Tytuł :
Role of astroglial toll-like receptors (TLRs) in central nervous system infections, injury and neurodegenerative diseases.
Autorzy :
Li L; The Reynolds Family Spine Laboratory, Department of Neurosurgery, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ 07103, United States.
Acioglu C; The Reynolds Family Spine Laboratory, Department of Neurosurgery, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ 07103, United States.
Heary RF; Department of Neurological Surgery, Hackensack Meridian School of Medicine, Nutley, NJ 07110, United States.
Elkabes S; The Reynolds Family Spine Laboratory, Department of Neurosurgery, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ 07103, United States. Electronic address: .
Pokaż więcej
Źródło :
Brain, behavior, and immunity [Brain Behav Immun] 2021 Jan; Vol. 91, pp. 740-755. Date of Electronic Publication: 2020 Oct 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Astrocytes/*metabolism
Neurodegenerative Diseases/*physiopathology
Toll-Like Receptors/*physiology
Animals ; Astrocytes/physiology ; Brain/metabolism ; Central Nervous System/immunology ; Central Nervous System/metabolism ; Central Nervous System Diseases/immunology ; Central Nervous System Infections/pathology ; Encephalitis/immunology ; Humans ; Immunity, Innate/physiology ; Microglia/metabolism ; Neurodegenerative Diseases/metabolism ; Neurons/metabolism ; Receptors, Pattern Recognition/immunology ; Signal Transduction ; Spinal Cord/pathology ; Spinal Cord Injuries/pathology ; Toll-Like Receptors/metabolism
Czasopismo naukowe
Tytuł :
Astrocyte deletion of α2-Na/K ATPase triggers episodic motor paralysis in mice via a metabolic pathway.
Autorzy :
Smith SE; Department of Neuroscience, Washington University School of Medicine, St. Louis, MO, 63110, USA.; MD-PhD Program, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Chen X; Department of Neuroscience, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Brier LM; MD-PhD Program, Washington University School of Medicine, St. Louis, MO, 63110, USA.; Department of Radiology, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Bumstead JR; Department of Radiology, Washington University School of Medicine, St. Louis, MO, 63110, USA.; Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, 63105, USA.
Rensing NR; Department of Neurology, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Ringel AE; Department of Cell Biology, Blavatnik Institute, Harvard Medical School, Boston, MA, 02115, USA.
Shin H; Department of Neuroscience, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Oldenborg A; Department of Neuroscience, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Crowley JR; Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Bice AR; Department of Radiology, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Dikranian K; Department of Neuroscience, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Ippolito JE; Department of Radiology, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Haigis MC; Department of Cell Biology, Blavatnik Institute, Harvard Medical School, Boston, MA, 02115, USA.
Papouin T; Department of Neuroscience, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Zhao G; Department of Neuroscience, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Wong M; Department of Neurology, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Culver JP; Department of Radiology, Washington University School of Medicine, St. Louis, MO, 63110, USA.; Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, 63105, USA.; Department of Physics, Washington University in St. Louis, St. Louis, MO, 63105, USA.
Bonni A; Department of Neuroscience, Washington University School of Medicine, St. Louis, MO, 63110, USA. .
Pokaż więcej
Źródło :
Nature communications [Nat Commun] 2020 Dec 02; Vol. 11 (1), pp. 6164. Date of Electronic Publication: 2020 Dec 02.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Transcriptome*
Astrocytes/*metabolism
Ataxia/*genetics
Metabolome/*genetics
Migraine with Aura/*genetics
Sodium-Potassium-Exchanging ATPase/*genetics
Animals ; Astrocytes/pathology ; Ataxia/metabolism ; Ataxia/pathology ; Brain/metabolism ; Brain/pathology ; Disease Models, Animal ; Electroencephalography ; Female ; Functional Neuroimaging ; Glycine/metabolism ; Male ; Mice ; Mice, Knockout ; Migraine with Aura/metabolism ; Migraine with Aura/pathology ; Rotarod Performance Test ; Serine/metabolism ; Sodium-Potassium-Exchanging ATPase/deficiency
Czasopismo naukowe
Tytuł :
The potential role of inflammation reaction in COVID-19 related posttraumatic stress disorder.
Autorzy :
Jiang Y; Department of Cardiology, The First Affiliated Hospital of Soochow University, Suzhou City, Jiangsu Province, PR China.
Huang Z; Department of Cardiology, The First Affiliated Hospital of Soochow University, Suzhou City, Jiangsu Province, PR China.
Mi L; Department of Cardiology, The First Affiliated Hospital of Soochow University, Suzhou City, Jiangsu Province, PR China.
Zhou Y; Department of Cardiology, The First Affiliated Hospital of Soochow University, Suzhou City, Jiangsu Province, PR China. Electronic address: .
Pokaż więcej
Źródło :
Asian journal of psychiatry [Asian J Psychiatr] 2020 Dec; Vol. 54, pp. 102405. Date of Electronic Publication: 2020 Aug 29.
Typ publikacji :
Letter
MeSH Terms :
Astrocytes/*immunology
Brain/*immunology
COVID-19/*immunology
Cytokines/*immunology
Inflammation/*immunology
Microglia/*immunology
Stress Disorders, Post-Traumatic/*immunology
Astrocytes/metabolism ; Glucocorticoids/immunology ; Glucocorticoids/metabolism ; Humans ; Indoleamine-Pyrrole 2,3,-Dioxygenase/metabolism ; Learning/physiology ; Memory/physiology ; Microglia/metabolism ; Neurogenesis/immunology ; Neuronal Plasticity/immunology ; Quinolinic Acid/metabolism ; Receptors, N-Methyl-D-Aspartate/metabolism ; Serotonin/metabolism ; Stress Disorders, Post-Traumatic/metabolism
Opinia redakcyjna
Tytuł :
Untangling Complexities of Glial-Neuronal Communications: Astroglial Metabolic Cascades Orchestrate Tonic Inhibition in the Thalamus.
Autorzy :
Verkhratsky A; Faculty of Biology, Medicine and Health, The University of Manchester, Manchester M13 9PT, UK; Achucarro Center for Neuroscience, IKERBASQUE, 48011 Bilbao, Spain. Electronic address: .
Pokaż więcej
Źródło :
Neuron [Neuron] 2020 Nov 25; Vol. 108 (4), pp. 585-587.
Typ publikacji :
Journal Article; Comment
MeSH Terms :
Astrocytes*
gamma-Aminobutyric Acid*
Neuroglia ; Neurons ; Thalamus
Czasopismo naukowe
Tytuł :
The loss of microglia activities facilitates glaucoma progression in association with CYP1B1 gene mutation (p.Gly61Glu).
Autorzy :
Alghamdi A; Biochemistry Department, King Saud University (KSU), Riyadh, Saudi Arabia.
Aldossary W; Biochemistry Department, King Saud University (KSU), Riyadh, Saudi Arabia.
Albahkali S; Stem Cells and Regenerative Medicine, King Abdullah International Medical Research Center (KAIMRC), Riyadh, Saudi Arabia.
Alotaibi B; Stem Cells and Regenerative Medicine, King Abdullah International Medical Research Center (KAIMRC), Riyadh, Saudi Arabia.
Alrfaei BM; Stem Cells and Regenerative Medicine, King Abdullah International Medical Research Center (KAIMRC), Riyadh, Saudi Arabia.; King Saud Bin Abdulaziz University for Health Sciences (KSAU-HS), Riyadh, Saudi Arabia.
Pokaż więcej
Źródło :
PloS one [PLoS One] 2020 Nov 10; Vol. 15 (11), pp. e0241902. Date of Electronic Publication: 2020 Nov 10 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Point Mutation*
Astrocytes/*cytology
Cytochrome P-450 CYP1B1/*genetics
Glaucoma/*congenital
Mesenchymal Stem Cells/*cytology
Microglia/*cytology
Amino Acid Substitution ; Animals ; Apoptosis ; Astrocytes/metabolism ; CRISPR-Cas Systems ; Cell Proliferation ; Cells, Cultured ; Cytokines/metabolism ; Glaucoma/genetics ; Humans ; Male ; Mesenchymal Stem Cells/metabolism ; Microglia/metabolism ; Models, Animal ; NADP/metabolism ; Rats
Czasopismo naukowe
Tytuł :
Spinal astrocytes in superficial laminae gate brainstem descending control of mechanosensory hypersensitivity.
Autorzy :
Kohro Y; Department of Life Innovation, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.
Matsuda T; Department of Life Innovation, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.
Yoshihara K; Department of Life Innovation, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.
Kohno K; Department of Life Innovation, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.
Koga K; Department of Life Innovation, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.
Katsuragi R; Department of Life Innovation, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.
Oka T; Department of Life Innovation, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.
Tashima R; Department of Life Innovation, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.
Muneta S; Department of Life Innovation, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.
Yamane T; Department of Life Innovation, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.
Okada S; Department of Life Innovation, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.
Momokino K; Department of Life Innovation, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.
Furusho A; Department of Drug Discovery and Evolution, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.
Hamase K; Department of Drug Discovery and Evolution, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.
Oti T; Department of Life Innovation, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.; Ushimado Marine Institute, Graduate School of Natural Science and Technology, Okayama University, Setouchi, Japan.
Sakamoto H; Ushimado Marine Institute, Graduate School of Natural Science and Technology, Okayama University, Setouchi, Japan.
Hayashida K; Department of Neurophysiology, Graduate School of Medicine, Akita University, Akita, Japan.
Kobayashi R; Laboratory of Genome Science, Biosignal Genome Resource Center, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Japan.
Horii T; Laboratory of Genome Science, Biosignal Genome Resource Center, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Japan.
Hatada I; Laboratory of Genome Science, Biosignal Genome Resource Center, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Japan.
Tozaki-Saitoh H; Department of Life Innovation, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.
Mikoshiba K; Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai, China.; Department of Biomolecular Science, Faculty of Science, Toho University, Funabashi, Japan.
Taylor V; Department of Biomedicine, University of Basel, Basel, Switzerland.
Inoue K; Department of Molecular and System Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.
Tsuda M; Department of Life Innovation, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan. .; Department of Molecular and System Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan. .
Pokaż więcej
Źródło :
Nature neuroscience [Nat Neurosci] 2020 Nov; Vol. 23 (11), pp. 1376-1387. Date of Electronic Publication: 2020 Oct 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Astrocytes/*physiology
Hyperalgesia/*physiopathology
Locus Coeruleus/*physiology
Neurons/*physiology
Nociception/*physiology
Spinal Cord Dorsal Horn/*physiology
Adrenergic Neurons/physiology ; Animals ; Astrocytes/metabolism ; Basic Helix-Loop-Helix Transcription Factors/analysis ; Female ; Hyperalgesia/chemically induced ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Inbred ICR ; Neural Pathways/physiology ; Receptors, Adrenergic, alpha-1/physiology ; Repressor Proteins/analysis ; Spinal Cord Dorsal Horn/metabolism
Czasopismo naukowe
Tytuł :
CD49f Is a Novel Marker of Functional and Reactive Human iPSC-Derived Astrocytes.
Autorzy :
Barbar L; The New York Stem Cell Foundation Research Institute, New York, NY 10019, USA.
Jain T; The New York Stem Cell Foundation Research Institute, New York, NY 10019, USA.
Zimmer M; The New York Stem Cell Foundation Research Institute, New York, NY 10019, USA.
Kruglikov I; The New York Stem Cell Foundation Research Institute, New York, NY 10019, USA.
Sadick JS; Neuroscience Institute, NYU Langone School of Medicine, New York, NY 10016, USA.
Wang M; Department of Genetics & Genomic Sciences, Mount Sinai Center for Transformative Disease Modeling, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Kalpana K; The New York Stem Cell Foundation Research Institute, New York, NY 10019, USA.
Rose IVL; Neuroscience Institute, NYU Langone School of Medicine, New York, NY 10016, USA.
Burstein SR; The New York Stem Cell Foundation Research Institute, New York, NY 10019, USA.
Rusielewicz T; The New York Stem Cell Foundation Research Institute, New York, NY 10019, USA.
Nijsure M; The New York Stem Cell Foundation Research Institute, New York, NY 10019, USA.
Guttenplan KA; Department of Neurobiology, Stanford University, Stanford, CA 94305, USA.
di Domenico A; The New York Stem Cell Foundation Research Institute, New York, NY 10019, USA.
Croft G; The New York Stem Cell Foundation Research Institute, New York, NY 10019, USA.
Zhang B; Department of Genetics & Genomic Sciences, Mount Sinai Center for Transformative Disease Modeling, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Nobuta H; Rose F. Kennedy Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Hébert JM; Rose F. Kennedy Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Liddelow SA; Neuroscience Institute, NYU Langone School of Medicine, New York, NY 10016, USA; Department of Neuroscience and Physiology, NYU Langone School of Medicine, New York, NY 10016, USA; Department of Ophthalmology, NYU Langone School of Medicine, New York, NY 10017, USA.
Fossati V; The New York Stem Cell Foundation Research Institute, New York, NY 10019, USA. Electronic address: .
Pokaż więcej
Źródło :
Neuron [Neuron] 2020 Aug 05; Vol. 107 (3), pp. 436-453.e12. Date of Electronic Publication: 2020 Jun 01.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Astrocytes/*metabolism
Induced Pluripotent Stem Cells/*metabolism
Integrin alpha6/*metabolism
Alzheimer Disease/metabolism ; Animals ; Astrocytes/physiology ; Biomarkers/metabolism ; Flow Cytometry ; Gene Expression Profiling ; Glutamic Acid/metabolism ; Humans ; Inflammation/metabolism ; Inflammation/physiopathology ; Mice ; Patch-Clamp Techniques ; Phagocytosis/physiology ; RNA-Seq ; Single-Cell Analysis
Czasopismo naukowe
Tytuł :
Brainwide Genetic Sparse Cell Labeling to Illuminate the Morphology of Neurons and Glia with Cre-Dependent MORF Mice.
Autorzy :
Veldman MB; Center for Neurobehavioral Genetics, Jane and Terry Semel Institute for Neuroscience and Human Behavior, and Department of Psychiatry and Biobehavioral Sciences, Brain Research Institute, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA 90095, USA.
Park CS; Center for Neurobehavioral Genetics, Jane and Terry Semel Institute for Neuroscience and Human Behavior, and Department of Psychiatry and Biobehavioral Sciences, Brain Research Institute, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA 90095, USA.
Eyermann CM; Center for Neurobehavioral Genetics, Jane and Terry Semel Institute for Neuroscience and Human Behavior, and Department of Psychiatry and Biobehavioral Sciences, Brain Research Institute, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA 90095, USA.
Zhang JY; Center for Neurobehavioral Genetics, Jane and Terry Semel Institute for Neuroscience and Human Behavior, and Department of Psychiatry and Biobehavioral Sciences, Brain Research Institute, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA 90095, USA.
Zuniga-Sanchez E; Department of Biological Chemistry, Howard Hughes Medical Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
Hirano AA; Department of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA; Veterans Administration of Greater Los Angeles Health System, Los Angeles, CA 90073, USA.
Daigle TL; Allen Institute for Brain Science, Seattle, WA 98109, USA.
Foster NN; Center for Integrative Connectomics, University of Southern California Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, USC, Los Angeles, CA, 90033, USA.
Zhu M; Center for Integrative Connectomics, University of Southern California Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, USC, Los Angeles, CA, 90033, USA.
Langfelder P; Center for Neurobehavioral Genetics, Jane and Terry Semel Institute for Neuroscience and Human Behavior, and Department of Psychiatry and Biobehavioral Sciences, Brain Research Institute, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA 90095, USA.
Lopez IA; Cellular and Molecular Biology of the Inner Ear Laboratory, Department of Head and Neck Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
Brecha NC; Department of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA; Veterans Administration of Greater Los Angeles Health System, Los Angeles, CA 90073, USA; Departments of Medicine and Ophthalmology, Stein Eye Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
Zipursky SL; Department of Biological Chemistry, Howard Hughes Medical Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
Zeng H; Allen Institute for Brain Science, Seattle, WA 98109, USA.
Dong HW; Center for Integrative Connectomics, University of Southern California Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, USC, Los Angeles, CA, 90033, USA; Zilkha Neurogenetic Institute, and Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Yang XW; Center for Neurobehavioral Genetics, Jane and Terry Semel Institute for Neuroscience and Human Behavior, and Department of Psychiatry and Biobehavioral Sciences, Brain Research Institute, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address: .
Pokaż więcej
Źródło :
Neuron [Neuron] 2020 Oct 14; Vol. 108 (1), pp. 111-127.e6. Date of Electronic Publication: 2020 Aug 13.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Video-Audio Media
MeSH Terms :
Astrocytes/*ultrastructure
Brain/*ultrastructure
Microglia/*ultrastructure
Neurons/*ultrastructure
Retinal Horizontal Cells/*ultrastructure
Animals ; Astrocytes/metabolism ; Astrocytes/pathology ; Brain/metabolism ; Brain/pathology ; Frameshift Mutation/genetics ; Green Fluorescent Proteins/genetics ; Integrases ; Mice ; Mice, Transgenic ; Microglia/metabolism ; Microglia/pathology ; Microsatellite Repeats/genetics ; Neurons/metabolism ; Neurons/pathology ; Retinal Horizontal Cells/metabolism ; Retinal Horizontal Cells/pathology
Czasopismo naukowe
Tytuł :
Transfer of pathological α-synuclein from neurons to astrocytes via exosomes causes inflammatory responses after METH exposure.
Autorzy :
Meng Y; School of Forensic Medicine, Southern Medical University, Guangzhou, China.
Ding J; School of Forensic Medicine, Southern Medical University, Guangzhou, China.
Li C; School of Forensic Medicine, Southern Medical University, Guangzhou, China.
Fan H; School of Forensic Medicine, Southern Medical University, Guangzhou, China; School of Basic Medicine and Life Science, Hainan Medical University, Haikou, China.
He Y; School of Forensic Medicine, Southern Medical University, Guangzhou, China.
Qiu P; School of Forensic Medicine, Southern Medical University, Guangzhou, China. Electronic address: .
Pokaż więcej
Źródło :
Toxicology letters [Toxicol Lett] 2020 Oct 01; Vol. 331, pp. 188-199. Date of Electronic Publication: 2020 Jun 20.
Typ publikacji :
Journal Article
MeSH Terms :
Astrocytes/*drug effects
Central Nervous System Stimulants/*toxicity
Exosomes/*metabolism
Methamphetamine/*toxicity
Neurons/*drug effects
Neurotoxicity Syndromes/*metabolism
alpha-Synuclein/*metabolism
Animals ; Astrocytes/immunology ; Astrocytes/metabolism ; Cell Line, Tumor ; Coculture Techniques ; Cytokines/metabolism ; Hippocampus/cytology ; Humans ; Injections, Intraperitoneal ; Male ; Mice, Inbred C57BL ; Neurons/immunology ; Neurons/metabolism ; Neurotoxicity Syndromes/immunology ; Nuclear Receptor Subfamily 4, Group A, Member 2/genetics ; Primary Cell Culture ; Synucleinopathies/immunology ; Synucleinopathies/metabolism
Czasopismo naukowe
Tytuł :
Effects of methylmercury on the pattern of NADPH diaphorase expression and astrocytic activation in the rat.
Autorzy :
Freire MAM; Graduate Program in Health and Society, Faculty of Health Sciences, University of State of Rio Grande do Norte (UERN), Mossoró, RN, Brazil.
Lima RR; Laboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Pará (UFPA), Belém, PA, Brazil.
Nascimento PC; Laboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Pará (UFPA), Belém, PA, Brazil.
Gomes-Leal W; Laboratory of Experimental Neuroprotection and Neuroregeneration, Institute of Biological Sciences, Federal University of Pará (UFPA), Belém, PA, Brazil.
Pereira A Jr; Department of Electrical and Biomedical Engineering, Institute of Technology, Federal University of Pará (UFPA), Belém, PA, Brazil. Electronic address: .
Pokaż więcej
Źródło :
Ecotoxicology and environmental safety [Ecotoxicol Environ Saf] 2020 Sep 15; Vol. 201, pp. 110799. Date of Electronic Publication: 2020 Jun 13.
Typ publikacji :
Journal Article
MeSH Terms :
Astrocytes/*drug effects
Environmental Pollutants/*toxicity
Methylmercury Compounds/*toxicity
NADPH Dehydrogenase/*metabolism
Neurons/*drug effects
Visual Cortex/*drug effects
Animals ; Astrocytes/enzymology ; Behavior, Animal/drug effects ; Environmental Pollutants/metabolism ; Gold ; Humans ; Male ; Methylmercury Compounds/metabolism ; Mining ; Neurons/enzymology ; Rats ; Rats, Wistar ; Visual Cortex/enzymology ; Visual Cortex/pathology
Czasopismo naukowe
Tytuł :
Astrocyte responses to experimental glaucoma in mouse optic nerve head.
Autorzy :
Quillen S; Glaucoma Center of Excellence, Wilmer Ophthalmological Institute, Johns Hopkins University, Baltimore, Maryland, United States of America.
Schaub J; Glaucoma Center of Excellence, Wilmer Ophthalmological Institute, Johns Hopkins University, Baltimore, Maryland, United States of America.
Quigley H; Glaucoma Center of Excellence, Wilmer Ophthalmological Institute, Johns Hopkins University, Baltimore, Maryland, United States of America.
Pease M; Glaucoma Center of Excellence, Wilmer Ophthalmological Institute, Johns Hopkins University, Baltimore, Maryland, United States of America.
Korneva A; Glaucoma Center of Excellence, Wilmer Ophthalmological Institute, Johns Hopkins University, Baltimore, Maryland, United States of America.
Kimball E; Glaucoma Center of Excellence, Wilmer Ophthalmological Institute, Johns Hopkins University, Baltimore, Maryland, United States of America.
Pokaż więcej
Źródło :
PloS one [PLoS One] 2020 Aug 21; Vol. 15 (8), pp. e0238104. Date of Electronic Publication: 2020 Aug 21 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Astrocytes/*physiology
Glaucoma/*pathology
Optic Nerve/*physiology
Animals ; Apoptosis ; Astrocytes/cytology ; Astrocytes/pathology ; Cell Proliferation ; Disease Models, Animal ; Glial Fibrillary Acidic Protein/metabolism ; Intraocular Pressure ; Mice ; Mice, Inbred C57BL ; Microscopy, Confocal ; Microscopy, Electron, Transmission ; Optic Nerve/cytology ; Optic Nerve/pathology
Czasopismo naukowe
Tytuł :
Redistribution of metabolic resources through astrocyte networks mitigates neurodegenerative stress.
Autorzy :
Cooper ML; Department of Ophthalmology and Visual Sciences, Vanderbilt University Medical Center, Nashville TN 37232-0654.
Pasini S; Department of Ophthalmology and Visual Sciences, Vanderbilt University Medical Center, Nashville TN 37232-0654.
Lambert WS; Department of Ophthalmology and Visual Sciences, Vanderbilt University Medical Center, Nashville TN 37232-0654.
D'Alessandro KB; Department of Ophthalmology and Visual Sciences, Vanderbilt University Medical Center, Nashville TN 37232-0654.
Yao V; Department of Ophthalmology and Visual Sciences, Vanderbilt University Medical Center, Nashville TN 37232-0654.
Risner ML; Department of Ophthalmology and Visual Sciences, Vanderbilt University Medical Center, Nashville TN 37232-0654.
Calkins DJ; Department of Ophthalmology and Visual Sciences, Vanderbilt University Medical Center, Nashville TN 37232-0654 .
Pokaż więcej
Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Aug 04; Vol. 117 (31), pp. 18810-18821. Date of Electronic Publication: 2020 Jul 20.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Astrocytes*/metabolism
Astrocytes*/physiology
Glaucoma/*metabolism
Neurodegenerative Diseases/*metabolism
Animals ; Connexin 43/genetics ; Connexin 43/metabolism ; Female ; Gap Junctions/metabolism ; Intraocular Pressure/physiology ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic
Czasopismo naukowe
Tytuł :
Isolation and characterization of human optic nerve head astrocytes and lamina cribrosa cells.
Autorzy :
Lopez NN; The North Texas Eye Research Institute, Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, Fort Worth, 3500 Camp Bowie Blvd., Fort Worth, TX, 76107, United States.
Clark AF; The North Texas Eye Research Institute, Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, Fort Worth, 3500 Camp Bowie Blvd., Fort Worth, TX, 76107, United States.
Tovar-Vidales T; The North Texas Eye Research Institute, Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, Fort Worth, 3500 Camp Bowie Blvd., Fort Worth, TX, 76107, United States. Electronic address: .
Pokaż więcej
Źródło :
Experimental eye research [Exp Eye Res] 2020 Aug; Vol. 197, pp. 108103. Date of Electronic Publication: 2020 Jun 06.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Astrocytes/*cytology
Extracellular Matrix Proteins/*metabolism
Glial Fibrillary Acidic Protein/*metabolism
Optic Disk/*cytology
Astrocytes/metabolism ; Blotting, Western ; Cells, Cultured ; Humans ; Optic Disk/metabolism
Czasopismo naukowe
Tytuł :
Distinctive cellular response to aluminum based adjuvants.
Autorzy :
Nies I; Department of Pharmaceutical Sciences, Western University of Health Sciences, Pomona, CA, United States.
Hidalgo K; Department of Pharmaceutical Sciences, Western University of Health Sciences, Pomona, CA, United States.
Bondy SC; Center for Occupational and Environmental Health, Department of Medicine, University of California, Irvine, CA, United States.
Campbell A; Department of Pharmaceutical Sciences, Western University of Health Sciences, Pomona, CA, United States. Electronic address: .
Pokaż więcej
Źródło :
Environmental toxicology and pharmacology [Environ Toxicol Pharmacol] 2020 Aug; Vol. 78, pp. 103404. Date of Electronic Publication: 2020 Apr 29.
Typ publikacji :
Journal Article
MeSH Terms :
Adjuvants, Immunologic/*pharmacology
Aluminum Compounds/*pharmacology
Astrocytes/*drug effects
Macrophages/*drug effects
Astrocytes/metabolism ; Cell Survival/drug effects ; Humans ; Interleukin-6/metabolism ; Macrophages/metabolism ; Reactive Oxygen Species/metabolism ; THP-1 Cells ; Tumor Necrosis Factor-alpha/metabolism
Czasopismo naukowe
Tytuł :
Quercetin and chloroquine synergistically kill glioma cells by inducing organelle stress and disrupting Ca homeostasis.
Autorzy :
Jang E; School of Life Sciences, Ulsan National Institute of Science and Technology, Ulsan 44919, Republic of Korea.
Kim IY; Department of Biomedical Sciences, Ajou University Graduate School of Medicine, Suwon 16499, Republic of Korea.
Kim H; School of Life Sciences, Ulsan National Institute of Science and Technology, Ulsan 44919, Republic of Korea.
Lee DM; Department of Biomedical Sciences, Ajou University Graduate School of Medicine, Suwon 16499, Republic of Korea.
Seo DY; Department of Biomedical Sciences, Ajou University Graduate School of Medicine, Suwon 16499, Republic of Korea.
Lee JA; Department of Biomedical Sciences, Ajou University Graduate School of Medicine, Suwon 16499, Republic of Korea.
Choi KS; Department of Biomedical Sciences, Ajou University Graduate School of Medicine, Suwon 16499, Republic of Korea; Department of Biochemistry and Molecular Biology, Ajou University, Suwon 16499, Republic of Korea. Electronic address: .
Kim E; School of Life Sciences, Ulsan National Institute of Science and Technology, Ulsan 44919, Republic of Korea. Electronic address: .
Pokaż więcej
Źródło :
Biochemical pharmacology [Biochem Pharmacol] 2020 Aug; Vol. 178, pp. 114098. Date of Electronic Publication: 2020 Jun 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents, Phytogenic/*pharmacology
Astrocytes/*drug effects
Chloroquine/*pharmacology
Endoplasmic Reticulum Stress/*drug effects
Neuroglia/*drug effects
Quercetin/*pharmacology
Astrocytes/metabolism ; Astrocytes/pathology ; Autophagosomes/drug effects ; Autophagosomes/metabolism ; Autophagosomes/pathology ; Autophagy/drug effects ; Calcium/metabolism ; Calcium Channels/genetics ; Calcium Channels/metabolism ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Drug Combinations ; Drug Synergism ; Gene Expression ; Homeostasis/drug effects ; Humans ; Inositol 1,4,5-Trisphosphate Receptors/genetics ; Inositol 1,4,5-Trisphosphate Receptors/metabolism ; Lysosomes/drug effects ; Lysosomes/metabolism ; Lysosomes/pathology ; Mitochondria/drug effects ; Mitochondria/metabolism ; Mitochondria/pathology ; Neuroglia/metabolism ; Neuroglia/pathology ; Reactive Oxygen Species/agonists ; Reactive Oxygen Species/metabolism
Czasopismo naukowe
Tytuł :
Astrocytes regulate brain extracellular pH via a neuronal activity-dependent bicarbonate shuttle.
Autorzy :
Theparambil SM; Centre for Cardiovascular and Metabolic Neuroscience, Neuroscience, Physiology and Pharmacology, University College London, London, UK.
Hosford PS; Centre for Cardiovascular and Metabolic Neuroscience, Neuroscience, Physiology and Pharmacology, University College London, London, UK.
Ruminot I; Centro de Estudios Científicos (CECs), Valdivia, Chile.
Kopach O; Institute of Neurology, University College London, London, UK.
Reynolds JR; Institute of Neurology, University College London, London, UK.
Sandoval PY; Centro de Estudios Científicos (CECs), Valdivia, Chile.
Rusakov DA; Institute of Neurology, University College London, London, UK.
Barros LF; Centro de Estudios Científicos (CECs), Valdivia, Chile.
Gourine AV; Centre for Cardiovascular and Metabolic Neuroscience, Neuroscience, Physiology and Pharmacology, University College London, London, UK. .
Pokaż więcej
Źródło :
Nature communications [Nat Commun] 2020 Oct 08; Vol. 11 (1), pp. 5073. Date of Electronic Publication: 2020 Oct 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Astrocytes/*metabolism
Bicarbonates/*metabolism
Brain/*metabolism
Extracellular Space/*metabolism
Acetazolamide/pharmacology ; Adenosine Triphosphate/metabolism ; Animals ; Astrocytes/drug effects ; Carbonic Anhydrases/metabolism ; Cells, Cultured ; Electric Stimulation ; Fluorescence ; Hippocampus/metabolism ; Hydrogen-Ion Concentration ; Mice, Inbred C57BL ; Models, Biological ; Neurons/drug effects ; Neurons/metabolism ; Purinergic Antagonists/pharmacology ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Rats, Sprague-Dawley ; Receptors, Purinergic/metabolism ; Signal Transduction ; Sodium-Bicarbonate Symporters/metabolism
Czasopismo naukowe

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies