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Tytuł :
Discovery and Synthesis of a Pyrimidine-Based Aurora Kinase Inhibitor to Reduce Levels of MYC Oncoproteins.
Autorzy :
Chi YH; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Zhunan 35053, Taiwan.; Graduate Institute of Biomedical Sciences, China Medical University, Taichung 40402, Taiwan.
Yeh TK; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Zhunan 35053, Taiwan.
Ke YY; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Zhunan 35053, Taiwan.
Lin WH; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Zhunan 35053, Taiwan.
Tsai CH; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Zhunan 35053, Taiwan.
Wang WP; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Zhunan 35053, Taiwan.
Chen YT; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Zhunan 35053, Taiwan.
Su YC; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Zhunan 35053, Taiwan.
Wang PC; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Zhunan 35053, Taiwan.
Chen YF; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Zhunan 35053, Taiwan.
Wu ZW; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Zhunan 35053, Taiwan.
Yeh JY; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Zhunan 35053, Taiwan.
Hung MC; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Zhunan 35053, Taiwan.
Wu MH; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Zhunan 35053, Taiwan.
Wang JY; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Zhunan 35053, Taiwan.
Chen CP; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Zhunan 35053, Taiwan.
Song JS; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Zhunan 35053, Taiwan.
Shih C; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Zhunan 35053, Taiwan.
Chen CT; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Zhunan 35053, Taiwan.
Chang CP; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Zhunan 35053, Taiwan.; Department of Chemistry, Chung Yuan Christian University, Taoyuan 320314, Taiwan.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2021 Jun 10; Vol. 64 (11), pp. 7312-7330. Date of Electronic Publication: 2021 May 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Design*
Aurora Kinase A/*antagonists & inhibitors
Protein Kinase Inhibitors/*chemical synthesis
Proto-Oncogene Proteins c-myc/*metabolism
Pyrimidines/*chemistry
Animals ; Aurora Kinase A/metabolism ; Aurora Kinase B/antagonists & inhibitors ; Aurora Kinase B/metabolism ; Binding Sites ; Cell Proliferation/drug effects ; Down-Regulation/drug effects ; Drug Evaluation, Preclinical ; Humans ; Lung Neoplasms/drug therapy ; Male ; Mice ; Mice, Inbred ICR ; Molecular Docking Simulation ; Protein Kinase Inhibitors/metabolism ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/therapeutic use ; Pyrimidines/metabolism ; Pyrimidines/pharmacology ; Pyrimidines/therapeutic use ; Small Cell Lung Carcinoma/drug therapy ; Structure-Activity Relationship ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
SUMO proteases SENP3 and SENP5 spatiotemporally regulate the kinase activity of Aurora A.
Autorzy :
Yu B; Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Department of Biochemistry and Molecular Cell Biology, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai 200025, China.; The Key Laboratory of Cell Proliferation and Differentiation of the Ministry of Education, College of Life Sciences, Peking University, Beijing 100871, China.
Lin Q; The Key Laboratory of Cell Proliferation and Differentiation of the Ministry of Education, College of Life Sciences, Peking University, Beijing 100871, China.
Huang C; Medical School, Kunming University of Science and Technology, Kunming 650091, China.
Zhang B; The Key Laboratory of Cell Proliferation and Differentiation of the Ministry of Education, College of Life Sciences, Peking University, Beijing 100871, China.
Wang Y; Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Department of Biochemistry and Molecular Cell Biology, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai 200025, China.
Jiang Q; The Key Laboratory of Cell Proliferation and Differentiation of the Ministry of Education, College of Life Sciences, Peking University, Beijing 100871, China.
Zhang C; The Key Laboratory of Cell Proliferation and Differentiation of the Ministry of Education, College of Life Sciences, Peking University, Beijing 100871, China.
Yi J; Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Department of Biochemistry and Molecular Cell Biology, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai 200025, China.
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Źródło :
Journal of cell science [J Cell Sci] 2021 Jul 01; Vol. 134 (13). Date of Electronic Publication: 2021 Jul 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Aurora Kinase A*/genetics
Peptide Hydrolases*/metabolism
Cysteine Endopeptidases/metabolism ; Humans ; Mitosis ; Phosphorylation ; Spindle Apparatus/genetics ; Spindle Apparatus/metabolism
Czasopismo naukowe
Tytuł :
Aurora kinase inhibitors: a patent review (2014-2020).
Autorzy :
Jing XL; School of Pharmacy, Lanzhou University, Lanzhou, China.
Chen SW; School of Pharmacy, Lanzhou University, Lanzhou, China.
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Źródło :
Expert opinion on therapeutic patents [Expert Opin Ther Pat] 2021 Jul; Vol. 31 (7), pp. 625-644. Date of Electronic Publication: 2021 Apr 13.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Aurora Kinases/*antagonists & inhibitors
Neoplasms/*drug therapy
Protein Kinase Inhibitors/*pharmacology
Animals ; Aurora Kinases/metabolism ; Cell Line, Tumor ; Drug Development ; Humans ; Neoplasms/enzymology ; Patents as Topic
Czasopismo naukowe
Tytuł :
Aurora kinase inhibition sensitizes melanoma cells to T-cell-mediated cytotoxicity.
Autorzy :
Punt S; Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, 77030, USA.
Malu S; Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, 77030, USA.; Immunitas Therapeutics, Cambridge, MA, USA.
McKenzie JA; Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, 77030, USA.; Eisai Inc., Woodcliff Lake, NJ, USA.
Manrique SZ; Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, 77030, USA.
Doorduijn EM; Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, 77030, USA.
Mbofung RM; Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, 77030, USA.; Merck Research Laboratories, Palo Alto, CA, USA.
Williams L; Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, 77030, USA.; KSQ Therapeutics Inc., Cambridge, MA, USA.
Silverman DA; Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, 77030, USA.
Ashkin EL; Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, 77030, USA.
Dominguez AL; Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, 77030, USA.
Wang Z; Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, 77030, USA.; Nature Cell Biology, Springer Nature, Shanghai City, China.
Chen JQ; Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, 77030, USA.; EMD Serono, Rockland, MA, USA.
Maiti SN; Department of Pediatrics, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, 77030, USA.
Tieu TN; Institute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, 77030, USA.; C4 Therapeutics, Watertown, MA, USA.
Liu C; Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, 77030, USA.
Xu C; Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, 77030, USA.; University of Houston, Houston, TX, USA.
Forget MA; Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, 77030, USA.
Haymaker C; Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, 77030, USA.
Khalili JS; Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, 77030, USA.; SystImmune Inc., Redmond, WA, USA.
Satani N; Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, 77030, USA.
Muller F; Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, 77030, USA.
Cooper LJN; Department of Pediatrics, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, 77030, USA.; ZIOPHARM Oncology Inc., Boston, MA, USA.
Overwijk WW; Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, 77030, USA.; Nektar Therapeutics, San Francisco, CA, USA.
Amaria RN; Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, 77030, USA.
Bernatchez C; Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, 77030, USA.
Heffernan TP; Institute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, 77030, USA.
Peng W; Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, 77030, USA.; University of Houston, Houston, TX, USA.
Roszik J; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, 77030, USA.
Hwu P; Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, 77030, USA. .; Sarcoma Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, 77030, USA. .; Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. .
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Źródło :
Cancer immunology, immunotherapy : CII [Cancer Immunol Immunother] 2021 Apr; Vol. 70 (4), pp. 1101-1113. Date of Electronic Publication: 2020 Oct 29.
Typ publikacji :
Journal Article
MeSH Terms :
Aurora Kinase A/*metabolism
Aurora Kinase B/*metabolism
Drug Resistance, Neoplasm/*immunology
Immunotherapy/*methods
Lymphocytes, Tumor-Infiltrating/*immunology
Melanoma/*immunology
T-Lymphocytes, Cytotoxic/*transplantation
Animals ; Apoptosis ; Aurora Kinase A/antagonists & inhibitors ; Aurora Kinase A/genetics ; Aurora Kinase B/antagonists & inhibitors ; Aurora Kinase B/genetics ; Cell Proliferation ; Female ; Humans ; Melanoma/genetics ; Melanoma/metabolism ; Melanoma/therapy ; Mice ; Prognosis ; Survival Rate ; T-Lymphocytes, Cytotoxic/immunology ; Tumor Cells, Cultured ; Tumor Microenvironment/immunology ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Aurora B kinase: a potential drug target for cancer therapy.
Autorzy :
Ahmed A; Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, Jamia Nagar, New Delhi, 110025, India.
Shamsi A; Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, Jamia Nagar, New Delhi, 110025, India.
Mohammad T; Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, Jamia Nagar, New Delhi, 110025, India.
Hasan GM; Department of Biochemistry, College of Medicine, Prince Sattam Bin Abdulaziz University, P.O. Box 173, Al-Kharj, 11942, Kingdom of Saudi Arabia.
Islam A; Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, Jamia Nagar, New Delhi, 110025, India.
Hassan MI; Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, Jamia Nagar, New Delhi, 110025, India. .
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Źródło :
Journal of cancer research and clinical oncology [J Cancer Res Clin Oncol] 2021 Aug; Vol. 147 (8), pp. 2187-2198. Date of Electronic Publication: 2021 May 28.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Molecular Targeted Therapy*/methods
Molecular Targeted Therapy*/trends
Aurora Kinase B/*physiology
Neoplasms/*therapy
Animals ; Antineoplastic Agents/therapeutic use ; Aurora Kinase B/antagonists & inhibitors ; Aurora Kinase B/genetics ; Cell Cycle/genetics ; Chromosomes/genetics ; Chromosomes/metabolism ; Disease Progression ; Humans ; Mitosis/genetics ; Neoplasms/etiology ; Neoplasms/pathology
Czasopismo naukowe
Tytuł :
Aurora Kinase B Inhibition: A Potential Therapeutic Strategy for Cancer.
Autorzy :
Borah NA; The Operation Eyesight Universal Institute for Eye Cancer, L.V. Prasad Eye Institute, Bhubaneswar 751024, India.; School of Biotechnology, KIIT University, Bhubaneswar 751024, India.
Reddy MM; The Operation Eyesight Universal Institute for Eye Cancer, L.V. Prasad Eye Institute, Bhubaneswar 751024, India.; School of Biotechnology, KIIT University, Bhubaneswar 751024, India.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2021 Apr 01; Vol. 26 (7). Date of Electronic Publication: 2021 Apr 01.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Biomarkers, Tumor*
Antineoplastic Agents/*pharmacology
Aurora Kinase B/*antagonists & inhibitors
Neoplasms/*metabolism
Protein Kinase Inhibitors/*pharmacology
Animals ; Antineoplastic Agents/therapeutic use ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Aurora Kinase B/chemistry ; Aurora Kinase B/genetics ; Aurora Kinase B/metabolism ; Carrier Proteins ; Disease Susceptibility ; Drug Design ; Drug Development ; Drug Resistance, Neoplasm/genetics ; Gene Expression Regulation, Enzymologic ; Gene Expression Regulation, Neoplastic ; Humans ; Molecular Targeted Therapy ; Multigene Family ; Neoplasms/drug therapy ; Neoplasms/etiology ; Protein Binding ; Protein Kinase Inhibitors/therapeutic use ; Signal Transduction/drug effects ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Heteroarene-fused anthraquinone derivatives as potential modulators for human aurora kinase B.
Autorzy :
Singh M; Department of Biophysics, All India Institute of Medical Sciences, New Delhi, Delhi, 110029, India.
Malhotra L; Department of Biophysics, All India Institute of Medical Sciences, New Delhi, Delhi, 110029, India.
Haque MA; Department of Biophysics, All India Institute of Medical Sciences, New Delhi, Delhi, 110029, India.
Kumar M; Department of Biophysics, All India Institute of Medical Sciences, New Delhi, Delhi, 110029, India.
Tikhomirov A; Gause Institute of New Antibiotics, Moscow, 11 B. Pirogovskaya Street, Moscow, 119021, Russia.
Litvinova V; Gause Institute of New Antibiotics, Moscow, 11 B. Pirogovskaya Street, Moscow, 119021, Russia.
Korolev AM; Gause Institute of New Antibiotics, Moscow, 11 B. Pirogovskaya Street, Moscow, 119021, Russia.
Ethayathulla AS; Department of Biophysics, All India Institute of Medical Sciences, New Delhi, Delhi, 110029, India.
Das U; Department of Biophysics, All India Institute of Medical Sciences, New Delhi, Delhi, 110029, India.
Shchekotikhin AE; Gause Institute of New Antibiotics, Moscow, 11 B. Pirogovskaya Street, Moscow, 119021, Russia.
Kaur P; Department of Biophysics, All India Institute of Medical Sciences, New Delhi, Delhi, 110029, India. Electronic address: .
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Źródło :
Biochimie [Biochimie] 2021 Mar; Vol. 182, pp. 152-165. Date of Electronic Publication: 2021 Jan 06.
Typ publikacji :
Journal Article
MeSH Terms :
Anthraquinones*/chemical synthesis
Anthraquinones*/chemistry
Anthraquinones*/pharmacology
Aurora Kinase B*/antagonists & inhibitors
Aurora Kinase B*/chemistry
Aurora Kinase B*/metabolism
Protein Kinase Inhibitors*/chemical synthesis
Protein Kinase Inhibitors*/chemistry
Protein Kinase Inhibitors*/pharmacology
Cell Line, Tumor ; Humans
Czasopismo naukowe
Tytuł :
Knockdown of AURKA sensitizes the efficacy of radiation in human colorectal cancer.
Autorzy :
Liu F; Department of Radiation Oncology, The First Affiliated Hospital of China Medical University, China.
Zhang Y; Department of Pathology, Cancer Hospital of China Medical University, Liaoning Cancer Hospital and Institute, China.
Dong Y; Department of Radiology, Cancer Hospital of China Medical University, Liaoning Cancer Hospital and Institute, China.
Ning P; Department of Pathology, Cancer Hospital of China Medical University, Liaoning Cancer Hospital and Institute, China.
Zhang Y; Department of Radiation Oncology, Cancer Hospital of China Medical University, Liaoning Cancer Hospital and Institute, China.
Sun H; Department of Radiation Oncology, Cancer Hospital of China Medical University, Liaoning Cancer Hospital and Institute, China.
Li G; Department of Radiation Oncology, The First Affiliated Hospital of China Medical University, China. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Apr 15; Vol. 271, pp. 119148. Date of Electronic Publication: 2021 Feb 02.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Expression Regulation, Neoplastic*
Aurora Kinase A/*antagonists & inhibitors
Aurora Kinase A/*genetics
Colorectal Neoplasms/*genetics
Colorectal Neoplasms/*radiotherapy
Aurora Kinase A/biosynthesis ; Cell Proliferation/radiation effects ; Colorectal Neoplasms/metabolism ; Gene Knockdown Techniques/methods ; HCT116 Cells ; HT29 Cells ; Humans ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Overlapping roles for PLK1 and Aurora A during meiotic centrosome biogenesis in mouse spermatocytes.
Autorzy :
Wellard SR; Biochemistry and Molecular Biology Department, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA.
Zhang Y; Biochemistry and Molecular Biology Department, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA.
Shults C; Biochemistry and Molecular Biology Department, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA.
Zhao X; Biochemistry and Molecular Biology Department, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA.
McKay M; The Jackson Laboratory, Bar Harbor, ME, USA.
Murray SA; The Jackson Laboratory, Bar Harbor, ME, USA.
Jordan PW; Biochemistry and Molecular Biology Department, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA.
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Źródło :
EMBO reports [EMBO Rep] 2021 Apr 07; Vol. 22 (4), pp. e51023. Date of Electronic Publication: 2021 Feb 21.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Aurora Kinase A*/genetics
Spermatocytes*
Animals ; Cell Cycle Proteins/genetics ; Centrosome ; Male ; Meiosis ; Mice ; Protein-Serine-Threonine Kinases ; Proto-Oncogene Proteins ; Spindle Apparatus
Czasopismo naukowe
Tytuł :
CircRNA-100284 activates aurora kinase B by inducing methylation of HSP70 via microRNA-217 to promote proliferation of bladder cancer cells.
Autorzy :
Huang ZM; Department of Urology, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, No.1 Shuaifuyuan Wangfujing, Dongcheng, Beijing, 100730, China.
Wang H; Department of Urology, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, No.1 Shuaifuyuan Wangfujing, Dongcheng, Beijing, 100730, China.
Ji ZG; Department of Urology, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, No.1 Shuaifuyuan Wangfujing, Dongcheng, Beijing, 100730, China. .
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Źródło :
Journal of cancer research and clinical oncology [J Cancer Res Clin Oncol] 2021 Mar; Vol. 147 (3), pp. 703-712. Date of Electronic Publication: 2021 Jan 01.
Typ publikacji :
Journal Article
MeSH Terms :
Aurora Kinase B/*metabolism
HSP70 Heat-Shock Proteins/*metabolism
MicroRNAs/*metabolism
RNA, Circular/*metabolism
Urinary Bladder Neoplasms/*metabolism
Animals ; Arsenites/pharmacology ; Aurora Kinase B/genetics ; Cell Cycle/physiology ; Cell Line, Tumor ; Cell Proliferation/physiology ; Cell Transformation, Neoplastic/chemically induced ; Cyclin D2/genetics ; Cyclin D2/metabolism ; Enhancer of Zeste Homolog 2 Protein/genetics ; Enhancer of Zeste Homolog 2 Protein/metabolism ; Enzyme Activation ; Female ; HSP70 Heat-Shock Proteins/genetics ; Heterografts ; Humans ; Methylation ; Mice ; MicroRNAs/genetics ; RNA, Circular/genetics ; Up-Regulation ; Urinary Bladder Neoplasms/genetics ; Urinary Bladder Neoplasms/pathology
Czasopismo naukowe
Tytuł :
Multi-omics analysis identifies potential mechanisms of AURKB in mediating poor outcome of lung adenocarcinoma.
Autorzy :
Huang J; Nanjing Medical University, Nanjing, China.; Department of Oncology, Nanjing Medical University Affiliated Hangzhou Hospital, Hangzhou, China.
Zhang Q; Nanjing Medical University, Nanjing, China.; Department of Oncology, Nanjing Medical University Affiliated Hangzhou Hospital, Hangzhou, China.
Shen J; Department of Oncology, Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Chen X; Department of Oncology, Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Ma S; Nanjing Medical University, Nanjing, China.; Department of Oncology, Nanjing Medical University Affiliated Hangzhou Hospital, Hangzhou, China.
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Źródło :
Aging [Aging (Albany NY)] 2021 Feb 17; Vol. 13 (4), pp. 5946-5966. Date of Electronic Publication: 2021 Feb 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Aurora Kinase B*/genetics
Aurora Kinase B*/metabolism
Adenocarcinoma of Lung/*genetics
Lung Neoplasms/*genetics
Aged ; Biomarkers ; Cell Cycle ; Female ; Humans ; Male ; MicroRNAs ; Middle Aged ; Prognosis
Czasopismo naukowe
Tytuł :
OTUD6A Is an Aurora Kinase A-Specific Deubiquitinase.
Autorzy :
Kim HJ; Department of Life Sciences, Sogang University, Seoul 04107, Korea.
Kim J; Department of Life Sciences, Sogang University, Seoul 04107, Korea.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Feb 16; Vol. 22 (4). Date of Electronic Publication: 2021 Feb 16.
Typ publikacji :
Journal Article
MeSH Terms :
Aurora Kinase A/*metabolism
Deubiquitinating Enzymes/*metabolism
Aurora Kinase A/genetics ; CDC2-CDC28 Kinases/genetics ; Cell Cycle Proteins/genetics ; Deubiquitinating Enzymes/genetics ; Gene Expression ; HEK293 Cells ; Half-Life ; Humans ; Open Reading Frames ; Phosphorylation ; Protein Stability ; Real-Time Polymerase Chain Reaction ; Transcription, Genetic/genetics ; Transfection
Czasopismo naukowe
Tytuł :
Bora phosphorylation substitutes in trans for T-loop phosphorylation in Aurora A to promote mitotic entry.
Autorzy :
Tavernier N; Centre for Systems Biology, Lunenfeld Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada.; Programme équipe Labellisée Ligue Contre le Cancer, Institut Jacques Monod, UMR7592, Université de Paris, CNRS, Paris, France.
Thomas Y; Programme équipe Labellisée Ligue Contre le Cancer, Institut Jacques Monod, UMR7592, Université de Paris, CNRS, Paris, France.
Vigneron S; Centre de Recherche de Biologie cellulaire de Montpellier, UMR 5237, Université de Montpellier, CNRS, Montpellier, France.
Maisonneuve P; Centre for Systems Biology, Lunenfeld Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada.
Orlicky S; Centre for Systems Biology, Lunenfeld Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada.
Mader P; Centre for Systems Biology, Lunenfeld Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada.
Regmi SG; Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, USA.
Van Hove L; Programme équipe Labellisée Ligue Contre le Cancer, Institut Jacques Monod, UMR7592, Université de Paris, CNRS, Paris, France.
Levinson NM; Department of Pharmacology, University of Minnesota, Minneapolis, MN, USA.
Gasmi-Seabrook G; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
Joly N; Programme équipe Labellisée Ligue Contre le Cancer, Institut Jacques Monod, UMR7592, Université de Paris, CNRS, Paris, France.
Poteau M; Institut Gustave Roussy CNRS UMR9019, Villejuif, France.
Velez-Aguilera G; Programme équipe Labellisée Ligue Contre le Cancer, Institut Jacques Monod, UMR7592, Université de Paris, CNRS, Paris, France.
Gavet O; Institut Gustave Roussy CNRS UMR9019, Villejuif, France.
Castro A; Centre de Recherche de Biologie cellulaire de Montpellier, UMR 5237, Université de Montpellier, CNRS, Montpellier, France.
Dasso M; Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, USA.
Lorca T; Centre de Recherche de Biologie cellulaire de Montpellier, UMR 5237, Université de Montpellier, CNRS, Montpellier, France.
Sicheri F; Centre for Systems Biology, Lunenfeld Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada. .; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada. .; Department of Biochemistry, University of Toronto, Toronto, ON, Canada. .
Pintard L; Programme équipe Labellisée Ligue Contre le Cancer, Institut Jacques Monod, UMR7592, Université de Paris, CNRS, Paris, France. .
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Źródło :
Nature communications [Nat Commun] 2021 Mar 26; Vol. 12 (1), pp. 1899. Date of Electronic Publication: 2021 Mar 26.
Typ publikacji :
Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Mitosis*
Aurora Kinase A/*metabolism
Cell Cycle Proteins/*metabolism
Threonine/*metabolism
Amino Acid Motifs/genetics ; Animals ; Aurora Kinase A/genetics ; Cell Cycle Proteins/genetics ; Cell Line, Tumor ; Cyclin A2/genetics ; Cyclin A2/metabolism ; Cyclin-Dependent Kinase 2/genetics ; Cyclin-Dependent Kinase 2/metabolism ; Enzyme Activation ; Female ; Humans ; Oocytes/metabolism ; Phosphorylation ; Proline/genetics ; Proline/metabolism ; Protein-Serine-Threonine Kinases/genetics ; Protein-Serine-Threonine Kinases/metabolism ; Proto-Oncogene Proteins/genetics ; Proto-Oncogene Proteins/metabolism ; Serine/genetics ; Serine/metabolism ; Threonine/genetics ; Xenopus laevis
Czasopismo naukowe
Tytuł :
MiRNA-621 exerts tumor suppressor function in gastric adenocarcinoma by targeting AURKA/GSK-3β pathway.
Autorzy :
Han X; Department of Gastrointestinal Surgery, the Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huai 'an, Jiangsu Province, 223001, China.
Liu H; Department of Obstetrics, the Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huai 'an, Jiangsu Province, 223001, China.
Tang X; Department of Gastrointestinal Surgery, the Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huai 'an, Jiangsu Province, 223001, China.
Zhao Y; Department of Gastrointestinal Surgery, the Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huai 'an, Jiangsu Province, 223001, China.
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Źródło :
Acta biochimica Polonica [Acta Biochim Pol] 2021 Feb 25; Vol. 68 (1), pp. 91-98.
Typ publikacji :
Journal Article
MeSH Terms :
Genes, Tumor Suppressor*
Adenocarcinoma/*metabolism
Aurora Kinase A/*metabolism
Glycogen Synthase Kinase 3 beta/*metabolism
MicroRNAs/*metabolism
Signal Transduction/*genetics
Stomach Neoplasms/*metabolism
Adenocarcinoma/pathology ; Adenocarcinoma/surgery ; Aurora Kinase A/genetics ; Cell Line, Tumor ; Cell Proliferation/genetics ; Cell Survival/genetics ; Disease Progression ; Down-Regulation ; Female ; Gene Knockdown Techniques ; Humans ; Male ; MicroRNAs/genetics ; Middle Aged ; Phosphorylation/genetics ; Stomach Neoplasms/pathology ; Stomach Neoplasms/surgery ; Transfection ; beta Catenin/metabolism
Czasopismo naukowe
Tytuł :
Loss of Aurora Kinase Signaling Allows Lung Cancer Cells to Adopt Endoreplication and Form Polyploid Giant Cancer Cells That Resist Antimitotic Drugs.
Autorzy :
Tagal V; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas. .
Roth MG; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas.; Harold Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas.
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Źródło :
Cancer research [Cancer Res] 2021 Jan 15; Vol. 81 (2), pp. 400-413. Date of Electronic Publication: 2020 Nov 10.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Drug Resistance, Neoplasm*
Antimitotic Agents/*pharmacology
Aurora Kinase A/*antagonists & inhibitors
Aurora Kinase B/*antagonists & inhibitors
Giant Cells/*drug effects
Lung Neoplasms/*drug therapy
Neoplastic Stem Cells/*drug effects
Apoptosis ; Aurora Kinase A/genetics ; Aurora Kinase A/metabolism ; Aurora Kinase B/genetics ; Aurora Kinase B/metabolism ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Cell Proliferation ; Endoreduplication ; Gene Expression Regulation, Neoplastic ; Giant Cells/metabolism ; Giant Cells/pathology ; Humans ; Lung Neoplasms/metabolism ; Lung Neoplasms/pathology ; Neoplastic Stem Cells/metabolism ; Neoplastic Stem Cells/pathology ; Tumor Cells, Cultured ; Tumor Microenvironment
Czasopismo naukowe
Tytuł :
Aurora B and C kinases regulate chromosome desynapsis and segregation during mouse and human spermatogenesis.
Autorzy :
Wellard SR; Department of Biochemistry and Molecular Biology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA.
Schindler K; Department of Genetics, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA.
Jordan PW; Department of Biochemistry and Molecular Biology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA .
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Źródło :
Journal of cell science [J Cell Sci] 2020 Dec 04; Vol. 133 (23). Date of Electronic Publication: 2020 Dec 04.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Aurora Kinase B*/genetics
Aurora Kinase C*/genetics
Meiosis*
Oocytes*
Spermatogenesis*/genetics
Animals ; Chromosome Segregation/genetics ; Humans ; Male ; Mice ; Spermatocytes
Czasopismo naukowe
Tytuł :
AT9283 exhibits antiproliferative effect on tyrosine kinase inhibitor‑sensitive and ‑resistant chronic myeloid leukemia cells by inhibition of Aurora A and Aurora B.
Autorzy :
Takeda T; Division of Pharmacotherapy, Kindai University School of Pharmacy, Higashi‑Osaka, Osaka 577‑8502, Japan.
Tsubaki M; Division of Pharmacotherapy, Kindai University School of Pharmacy, Higashi‑Osaka, Osaka 577‑8502, Japan.
Genno S; Division of Pharmacotherapy, Kindai University School of Pharmacy, Higashi‑Osaka, Osaka 577‑8502, Japan.
Nemoto C; Division of Pharmacotherapy, Kindai University School of Pharmacy, Higashi‑Osaka, Osaka 577‑8502, Japan.
Onishi Y; Division of Pharmacotherapy, Kindai University School of Pharmacy, Higashi‑Osaka, Osaka 577‑8502, Japan.
Yamamoto Y; Division of Pharmacotherapy, Kindai University School of Pharmacy, Higashi‑Osaka, Osaka 577‑8502, Japan.
Imano M; Department of Surgery, Kindai University School of Medicine, Osakasayama, Osaka 589‑0014, Japan.
Satou T; Department of Pathology, Kindai University School of Medicine, Osakasayama, Osaka 589‑0014, Japan.
Nishida S; Division of Pharmacotherapy, Kindai University School of Pharmacy, Higashi‑Osaka, Osaka 577‑8502, Japan.
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Źródło :
Oncology reports [Oncol Rep] 2020 Nov; Vol. 44 (5), pp. 2211-2218. Date of Electronic Publication: 2020 Aug 18.
Typ publikacji :
Journal Article
MeSH Terms :
Aurora Kinase A/*antagonists & inhibitors
Aurora Kinase B/*antagonists & inhibitors
Benzimidazoles/*pharmacology
Leukemia, Myelogenous, Chronic, BCR-ABL Positive/*drug therapy
Protein Kinase Inhibitors/*pharmacology
Urea/*analogs & derivatives
Aurora Kinase A/metabolism ; Aurora Kinase B/metabolism ; Benzimidazoles/therapeutic use ; Cell Line, Tumor ; Cell Survival/drug effects ; Drug Resistance, Neoplasm ; Drug Screening Assays, Antitumor ; Humans ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/pathology ; Protein Kinase Inhibitors/therapeutic use ; Urea/pharmacology ; Urea/therapeutic use
Czasopismo naukowe
Tytuł :
Inhibition of BRD4 triggers cellular senescence through suppressing aurora kinases in oesophageal cancer cells.
Autorzy :
Xu JL; Department of Biochemistry, School of Basic Medical Sciences, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China.
Yuan YJ; Department of Biochemistry, School of Basic Medical Sciences, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China.; Department of Clinical Laboratory, People's Hospital of Jimo District, Qingdao, China.
Lv J; Department of Biochemistry, School of Basic Medical Sciences, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China.
Qi D; Department of Biochemistry, School of Basic Medical Sciences, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China.
Wu MD; Department of Biochemistry, School of Basic Medical Sciences, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China.
Lan J; Department of Biochemistry, School of Basic Medical Sciences, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China.
Liu SN; Department of Biochemistry, School of Basic Medical Sciences, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China.
Yang Y; Department of Clinical Laboratory, The Second Affiliated Hospital of Shandong First Medical University, Taian, China.
Zhai J; Department of Biochemistry, School of Basic Medical Sciences, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China.
Jiang HM; Department of Biochemistry, School of Basic Medical Sciences, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China.
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Źródło :
Journal of cellular and molecular medicine [J Cell Mol Med] 2020 Nov; Vol. 24 (22), pp. 13036-13045. Date of Electronic Publication: 2020 Sep 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Aurora Kinase A*/metabolism
Aurora Kinase B*/metabolism
Cellular Senescence*
Cell Cycle Proteins/*antagonists & inhibitors
Esophageal Neoplasms/*metabolism
Transcription Factors/*antagonists & inhibitors
Apoptosis ; Azepines/pharmacology ; Cell Cycle ; Cell Cycle Proteins/metabolism ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Survival ; Down-Regulation ; Epigenesis, Genetic ; Gene Expression Regulation, Neoplastic ; Histones/metabolism ; Humans ; Nuclear Proteins/genetics ; RNA, Small Interfering/metabolism ; Transcription Factors/metabolism ; Triazoles/pharmacology ; Up-Regulation
Czasopismo naukowe
Tytuł :
Direct Phosphorylation and Stabilization of MYC by Aurora B Kinase Promote T-cell Leukemogenesis.
Autorzy :
Jiang J; Department of Hematology, Zhongnan Hospital of Wuhan University, Wuhan 430071, China; Frontier Science Center for Immunology and Metabolism, Medical Research Institute, Wuhan University, Wuhan 430071, China.
Wang J; Department of Hematology, Zhongnan Hospital of Wuhan University, Wuhan 430071, China; Frontier Science Center for Immunology and Metabolism, Medical Research Institute, Wuhan University, Wuhan 430071, China.
Yue M; Department of Pharmacy, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430014, China.
Cai X; State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Innovation Academy for Seed Design, Chinese Academy of Sciences, Wuhan 430072, China.
Wang T; Frontier Science Center for Immunology and Metabolism, Medical Research Institute, Wuhan University, Wuhan 430071, China.
Wu C; Frontier Science Center for Immunology and Metabolism, Medical Research Institute, Wuhan University, Wuhan 430071, China.
Su H; Frontier Science Center for Immunology and Metabolism, Medical Research Institute, Wuhan University, Wuhan 430071, China.
Wang Y; Department of Histology and Embryology, School of Basic Medical Science, Wuhan University, Wuhan 430071, China.
Han M; MOE Key Laboratory of Bioinformatics, School of Life Sciences, Tsinghua University, Beijing 100084, China.
Zhang Y; State Key Laboratory of Experimental Hematology and Division of Pediatric Blood Diseases Center, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300020, China.
Zhu X; State Key Laboratory of Experimental Hematology and Division of Pediatric Blood Diseases Center, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300020, China.
Jiang P; School of Life Sciences, Tsinghua University, Collaborative Innovation Center for Cancer Medicine, Beijing 100084, China.
Li P; South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China.
Sun Y; Departments of Pharmacology and Medicine, Section of Hematology and Medical Oncology, Cancer Research Center, Boston University School of Medicine, Boston, MA 02118, USA.
Xiao W; State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Innovation Academy for Seed Design, Chinese Academy of Sciences, Wuhan 430072, China.
Feng H; Departments of Pharmacology and Medicine, Section of Hematology and Medical Oncology, Cancer Research Center, Boston University School of Medicine, Boston, MA 02118, USA.
Qing G; Department of Hematology, Zhongnan Hospital of Wuhan University, Wuhan 430071, China; Frontier Science Center for Immunology and Metabolism, Medical Research Institute, Wuhan University, Wuhan 430071, China.
Liu H; Department of Hematology, Zhongnan Hospital of Wuhan University, Wuhan 430071, China; Frontier Science Center for Immunology and Metabolism, Medical Research Institute, Wuhan University, Wuhan 430071, China. Electronic address: .
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Źródło :
Cancer cell [Cancer Cell] 2020 Feb 10; Vol. 37 (2), pp. 200-215.e5.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Aurora Kinase B/*metabolism
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/*immunology
T-Lymphocytes/*immunology
Animals ; Aurora Kinase A/genetics ; Aurora Kinase A/immunology ; Aurora Kinase B/immunology ; Cell Line, Tumor ; F-Box-WD Repeat-Containing Protein 7/immunology ; Humans ; Mice ; Phosphorylation ; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/drug therapy ; Protein Kinase Inhibitors/pharmacology ; T-Lymphocytes/drug effects ; Transcriptional Activation/drug effects ; Transcriptional Activation/immunology ; Zebrafish
Czasopismo naukowe
Tytuł :
Role of AURKA in the hypothalamus-pituitary-testicular axis in Tibetan sheep from Tianzhu.
Autorzy :
Wang Y; College of Veterinary Medicine, Gansu Agricultural University, Lanzhou, China.
Yang Y; College of Veterinary Medicine, Gansu Agricultural University, Lanzhou, China.
Gan Z; College of Life Science and Technology, Gansu Agricultural University, Lanzhou, China.
Zhao C; College of Life Science and Technology, Gansu Agricultural University, Lanzhou, China.
Lv C; College of Veterinary Medicine, Gansu Agricultural University, Lanzhou, China.
Zhang Y; College of Veterinary Medicine, Gansu Agricultural University, Lanzhou, China; College of Life Science and Technology, Gansu Agricultural University, Lanzhou, China.
Zhao X; College of Veterinary Medicine, Gansu Agricultural University, Lanzhou, China; College of Life Science and Technology, Gansu Agricultural University, Lanzhou, China. Electronic address: .
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Źródło :
General and comparative endocrinology [Gen Comp Endocrinol] 2021 Jan 01; Vol. 300, pp. 113617. Date of Electronic Publication: 2020 Sep 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Aurora Kinase A/*metabolism
Hypothalamus/*enzymology
Pituitary Gland/*enzymology
Sheep/*metabolism
Testis/*enzymology
Amino Acid Sequence ; Animals ; Aurora Kinase A/chemistry ; Aurora Kinase A/genetics ; Gene Expression Profiling ; Gene Expression Regulation, Enzymologic ; Male ; Phylogeny ; Tibet
Czasopismo naukowe

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