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Wyszukujesz frazę ""autophagy"" wg kryterium: Temat


Starter badań:

Tytuł :
Non-canonical autophagy drives alternative ATG8 conjugation to phosphatidylserine.
Autorzy :
Durgan J; Signalling Programme, Babraham Institute, Cambridge, UK.
Lystad AH; Department of Molecular Medicine, University of Oslo, Oslo, Norway.
Sloan K; Signalling Programme, Babraham Institute, Cambridge, UK.
Carlsson SR; Department of Medical Biochemistry and Biophysics, Umeå University, Umeå, Sweden.
Wilson MI; Signalling Programme, Babraham Institute, Cambridge, UK.
Marcassa E; Francis Crick Institute, London, UK.
Ulferts R; Francis Crick Institute, London, UK.
Webster J; Mass Spectrometry Facility, Babraham Institute, Cambridge, UK.
Lopez-Clavijo AF; Lipidomics Facility, Babraham Institute, Cambridge, UK.
Wakelam MJ; Signalling Programme, Babraham Institute, Cambridge, UK; Lipidomics Facility, Babraham Institute, Cambridge, UK.
Beale R; Francis Crick Institute, London, UK.
Simonsen A; Department of Molecular Medicine, University of Oslo, Oslo, Norway.
Oxley D; Mass Spectrometry Facility, Babraham Institute, Cambridge, UK.
Florey O; Signalling Programme, Babraham Institute, Cambridge, UK. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2021 May 06; Vol. 81 (9), pp. 2031-2040.e8. Date of Electronic Publication: 2021 Apr 27.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Autophagy*
Protein Processing, Post-Translational*
Adaptor Proteins, Signal Transducing/*metabolism
Autophagosomes/*metabolism
Autophagy-Related Protein 8 Family/*metabolism
Microtubule-Associated Proteins/*metabolism
Phosphatidylserines/*metabolism
Adaptor Proteins, Signal Transducing/genetics ; Animals ; Autophagosomes/drug effects ; Autophagosomes/genetics ; Autophagosomes/pathology ; Autophagy-Related Protein 8 Family/genetics ; Autophagy-Related Proteins/genetics ; Autophagy-Related Proteins/metabolism ; Cysteine Endopeptidases/genetics ; Cysteine Endopeptidases/metabolism ; Female ; HCT116 Cells ; HEK293 Cells ; HeLa Cells ; Humans ; Influenza A virus/pathogenicity ; Macrolides/pharmacology ; Male ; Mice ; Microtubule-Associated Proteins/genetics ; Monensin/pharmacology ; Phagocytosis ; Phosphatidylethanolamines/metabolism ; RAW 264.7 Cells ; Signal Transduction
Czasopismo naukowe
Tytuł :
ATG101 Degradation by HUWE1-Mediated Ubiquitination Impairs Autophagy and Reduces Survival in Cancer Cells.
Autorzy :
Lee J; Department of Cancer Biomedical Science, Graduate School of Cancer Science & Policy, National Cancer Center, Goyang-si 10408, Korea.
Kim J; Department of Cancer Biomedical Science, Graduate School of Cancer Science & Policy, National Cancer Center, Goyang-si 10408, Korea.; Division of Cancer Biology, Research Institute, National Cancer Center, Goyang-si 10408, Korea.
Shin J; Department of Cancer Biomedical Science, Graduate School of Cancer Science & Policy, National Cancer Center, Goyang-si 10408, Korea.
Kang Y; Department of Cancer Biomedical Science, Graduate School of Cancer Science & Policy, National Cancer Center, Goyang-si 10408, Korea.
Choi J; Division of Cancer Biology, Research Institute, National Cancer Center, Goyang-si 10408, Korea.
Cheong H; Department of Cancer Biomedical Science, Graduate School of Cancer Science & Policy, National Cancer Center, Goyang-si 10408, Korea.; Division of Cancer Biology, Research Institute, National Cancer Center, Goyang-si 10408, Korea.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Aug 25; Vol. 22 (17). Date of Electronic Publication: 2021 Aug 25.
Typ publikacji :
Journal Article
MeSH Terms :
Autophagy*
Ubiquitination*
Autophagy-Related Proteins/*metabolism
Neoplasms/*metabolism
Tumor Suppressor Proteins/*metabolism
Ubiquitin-Protein Ligases/*metabolism
Vesicular Transport Proteins/*metabolism
Autophagy-Related Proteins/genetics ; Cell Survival ; HEK293 Cells ; HeLa Cells ; Humans ; Membrane Proteins/metabolism ; Phosphate-Binding Proteins/metabolism ; Vesicular Transport Proteins/genetics
Czasopismo naukowe
Tytuł :
Beyond Autophagy: The Expanding Roles of ATG8 Proteins.
Autorzy :
Nieto-Torres JL; Sanford Burnham Prebys Medical Discovery Institute, Program of Development, Aging, and Regeneration, La Jolla, CA, USA.
Leidal AM; Department of Pathology and Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA.
Debnath J; Department of Pathology and Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA. Electronic address: .
Hansen M; Sanford Burnham Prebys Medical Discovery Institute, Program of Development, Aging, and Regeneration, La Jolla, CA, USA. Electronic address: .
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Źródło :
Trends in biochemical sciences [Trends Biochem Sci] 2021 Aug; Vol. 46 (8), pp. 673-686. Date of Electronic Publication: 2021 Feb 05.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Autophagy*
Microtubule-Associated Proteins*
Autophagosomes ; Autophagy-Related Protein 8 Family ; Autophagy-Related Proteins ; Lysosomes
Czasopismo naukowe
Tytuł :
Cross talk between autophagy and oncogenic signaling pathways and implications for cancer therapy.
Autorzy :
Zada S; Department of Biochemistry and Convergence Medical Sciences and Institute of Health Sciences, Gyeongsang National University College of Medicine, Jinju 527-27, Republic of Korea.
Hwang JS; Department of Biochemistry and Convergence Medical Sciences and Institute of Health Sciences, Gyeongsang National University College of Medicine, Jinju 527-27, Republic of Korea.
Ahmed M; Department of Biochemistry and Convergence Medical Sciences and Institute of Health Sciences, Gyeongsang National University College of Medicine, Jinju 527-27, Republic of Korea.
Lai TH; Department of Biochemistry and Convergence Medical Sciences and Institute of Health Sciences, Gyeongsang National University College of Medicine, Jinju 527-27, Republic of Korea.
Pham TM; Department of Biochemistry and Convergence Medical Sciences and Institute of Health Sciences, Gyeongsang National University College of Medicine, Jinju 527-27, Republic of Korea.
Elashkar O; Department of Biochemistry and Convergence Medical Sciences and Institute of Health Sciences, Gyeongsang National University College of Medicine, Jinju 527-27, Republic of Korea.
Kim DR; Department of Biochemistry and Convergence Medical Sciences and Institute of Health Sciences, Gyeongsang National University College of Medicine, Jinju 527-27, Republic of Korea. Electronic address: .
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Źródło :
Biochimica et biophysica acta. Reviews on cancer [Biochim Biophys Acta Rev Cancer] 2021 Aug; Vol. 1876 (1), pp. 188565. Date of Electronic Publication: 2021 May 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Autophagy*/drug effects
Autophagy-Related Proteins/*metabolism
Neoplasms/*metabolism
Oncogene Proteins/*metabolism
Animals ; Antineoplastic Agents/therapeutic use ; Autophagy-Related Proteins/genetics ; Cell Movement ; Epithelial-Mesenchymal Transition ; Gene Expression Regulation, Neoplastic ; Humans ; Molecular Targeted Therapy ; Neoplasm Metastasis ; Neoplasms/drug therapy ; Neoplasms/genetics ; Neoplasms/pathology ; Oncogene Proteins/genetics ; Signal Transduction
Czasopismo naukowe
Tytuł :
Nrg1β Released in Remote Ischemic Preconditioning Improves Myocardial Perfusion and Decreases Ischemia/Reperfusion Injury via ErbB2-Mediated Rescue of Endothelial Nitric Oxide Synthase and Abrogation of Trx2 Autophagy.
Autorzy :
Kundumani-Sridharan V; Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock.
Subramani J; Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock.
Owens C; Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock.
Das KC; Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock.
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Źródło :
Arteriosclerosis, thrombosis, and vascular biology [Arterioscler Thromb Vasc Biol] 2021 Aug; Vol. 41 (8), pp. 2293-2314. Date of Electronic Publication: 2021 May 27.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Autophagy*
Ischemic Preconditioning*
Endothelial Cells/*metabolism
Hindlimb/*blood supply
Myocardial Reperfusion Injury/*prevention & control
Myocardium/*enzymology
Neuregulin-1/*metabolism
Nitric Oxide Synthase Type III/*metabolism
Receptor, ErbB-2/*metabolism
Thioredoxins/*metabolism
Animals ; Antibodies, Neutralizing/pharmacology ; Autophagy-Related Protein 5/metabolism ; Cells, Cultured ; Disease Models, Animal ; Endothelial Cells/drug effects ; Humans ; Male ; Mice, Inbred C57BL ; Mice, Knockout ; Myocardial Reperfusion Injury/enzymology ; Myocardial Reperfusion Injury/genetics ; Myocardial Reperfusion Injury/pathology ; Myocardium/pathology ; Neuregulin-1/antagonists & inhibitors ; Phosphorylation ; Protein Stability ; Proteolysis ; Receptor, ErbB-2/genetics ; Signal Transduction ; src-Family Kinases/metabolism
Czasopismo naukowe
Tytuł :
ATG4D role in mAtg8s delipidation and neuroprotection.
Autorzy :
Tamargo-Gómez I; Departamento de Biología Funcional, Facultad de Medicina, Universidad de Oviedo, Oviedo, Spain.; Instituto Universitario de Oncología (IUOPA), Oviedo, Spain.; Autophagy and Metabolism Lab, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain.
Martínez-García GG; Departamento de Biología Funcional, Facultad de Medicina, Universidad de Oviedo, Oviedo, Spain.; Instituto Universitario de Oncología (IUOPA), Oviedo, Spain.; Autophagy and Metabolism Lab, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain.
Suárez MF; Autophagy and Metabolism Lab, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain.
Fernández AF; Instituto Universitario de Oncología (IUOPA), Oviedo, Spain.; Universidad de Oviedo, Oviedo, Spain.
Mariño G; Departamento de Biología Funcional, Facultad de Medicina, Universidad de Oviedo, Oviedo, Spain.; Instituto Universitario de Oncología (IUOPA), Oviedo, Spain.; Autophagy and Metabolism Lab, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain.
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Źródło :
Autophagy [Autophagy] 2021 Jun; Vol. 17 (6), pp. 1558-1560. Date of Electronic Publication: 2021 May 07.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Comment
MeSH Terms :
Autophagy*
Neuroprotection*
Autophagy-Related Protein 8 Family ; Autophagy-Related Proteins
Czasopismo naukowe
Tytuł :
RNA-dependent protein kinase is required for interferon-γ-induced autophagy in MG63 osteosarcoma cells.
Autorzy :
Xu J; Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN, USA; Musculoskeletal Center, Peking University People's Hospital, Beijing, China.
Ji Y; Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN, USA; Department of Orthopedic Oncology, Qilu Hospital (Qingdao), Shandong University, Qingdao, China.
Shogren KL; Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN, USA.
Okuno SH; Department of Oncology, Mayo Clinic, Rochester, MN, USA.
Yaszemski MJ; Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN, USA.
Maran A; Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN, USA. Electronic address: .
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Źródło :
Gene [Gene] 2021 Nov 15; Vol. 802, pp. 145865. Date of Electronic Publication: 2021 Aug 02.
Typ publikacji :
Journal Article
MeSH Terms :
Autophagy*
Bone Neoplasms/*enzymology
Interferon-gamma/*metabolism
Osteosarcoma/*enzymology
eIF-2 Kinase/*metabolism
Autophagy-Related Protein 7/metabolism ; Bone Neoplasms/metabolism ; Osteosarcoma/metabolism ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
Knockdown of PEX16 Induces Autophagic Degradation of Peroxisomes.
Autorzy :
Wei X; Department of Biomedical Science & Engineering, Gwangju Institute of Science and Technology, Gwangju 61005, Korea.
Maharjan Y; Department of Biomedical Science & Engineering, Gwangju Institute of Science and Technology, Gwangju 61005, Korea.
Dorotea D; Department of Biomedical Science & Engineering, Gwangju Institute of Science and Technology, Gwangju 61005, Korea.
Dutta RK; Department of Biomedical Science & Engineering, Gwangju Institute of Science and Technology, Gwangju 61005, Korea.
Kim D; Department of Biomedical Science & Engineering, Gwangju Institute of Science and Technology, Gwangju 61005, Korea.
Kim H; Department of Biomedical Science & Engineering, Gwangju Institute of Science and Technology, Gwangju 61005, Korea.
Mu Y; Department of Biomedical Science & Engineering, Gwangju Institute of Science and Technology, Gwangju 61005, Korea.
Park C; Department of Biomedical Science & Engineering, Gwangju Institute of Science and Technology, Gwangju 61005, Korea.
Park R; Department of Biomedical Science & Engineering, Gwangju Institute of Science and Technology, Gwangju 61005, Korea.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jul 26; Vol. 22 (15). Date of Electronic Publication: 2021 Jul 26.
Typ publikacji :
Journal Article
MeSH Terms :
Autophagy*
Gene Knockdown Techniques*
Membrane Proteins/*deficiency
Peroxisomes/*metabolism
Retinal Pigment Epithelium/*metabolism
ATP-Binding Cassette Transporters/genetics ; ATP-Binding Cassette Transporters/metabolism ; Autophagy-Related Protein 5/genetics ; Autophagy-Related Protein 5/metabolism ; Cell Line ; Humans ; Membrane Proteins/metabolism ; Peroxisomes/genetics
Czasopismo naukowe
Tytuł :
Pathogenic Single Nucleotide Polymorphisms on Autophagy-Related Genes.
Autorzy :
Tamargo-Gómez I; Instituto de Investigación Sanitaria del Principado de Asturias, 33011 Oviedo, Spain.; Departamento de Biología Funcional, Universidad de Oviedo, 33011 Oviedo, Spain.
Fernández ÁF; Instituto de Investigación Sanitaria del Principado de Asturias, 33011 Oviedo, Spain.; Departamento de Biología Funcional, Universidad de Oviedo, 33011 Oviedo, Spain.
Mariño G; Instituto de Investigación Sanitaria del Principado de Asturias, 33011 Oviedo, Spain.; Departamento de Biología Funcional, Universidad de Oviedo, 33011 Oviedo, Spain.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Nov 02; Vol. 21 (21). Date of Electronic Publication: 2020 Nov 02.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Autophagy*
Polymorphism, Single Nucleotide*
Autophagy-Related Proteins/*genetics
Protein Kinase C/*genetics
Animals ; Autophagy-Related Protein 12/genetics ; Autophagy-Related Protein 5/genetics ; Autophagy-Related Protein 8 Family/genetics ; Cell Membrane/metabolism ; Cytosol/metabolism ; Humans ; Immune System ; Inflammation ; Lysosomes/metabolism ; Prognosis
Czasopismo naukowe
Tytuł :
IL37 overexpression inhibits autophagy and apoptosis induced by hepatic ischemia reperfusion injury via modulating AMPK/mTOR/ULLK1 signalling pathways.
Autorzy :
Chen QS; Department of hepatobiliary surgery, the first affiliated Hospital of Chongqing Medical University, Chongqing, China.
Shen A; Department of hepatobiliary pancreatic Cancer Center, Chongqing University Cancer Hospital, Chongqing, China.
Dai JW; Department of hepatobiliary surgery, the first affiliated Hospital of Chongqing Medical University, Chongqing, China.
Li TT; Department of hepatobiliary surgery, the first affiliated Hospital of Chongqing Medical University, Chongqing, China.
Huang WF; Department of hepatobiliary surgery, the first affiliated Hospital of Chongqing Medical University, Chongqing, China.
Shi K; Department of hepatobiliary surgery, the first affiliated Hospital of Chongqing Medical University, Chongqing, China.
Deng Y; Department of hepatobiliary surgery, the first affiliated Hospital of Chongqing Medical University, Chongqing, China; Department of oncology, Yongchuan Hospital of Chongqing Medical University, Chongqing, China.
Pan L; Department of hepatobiliary surgery, the first affiliated Hospital of Chongqing Medical University, Chongqing, China.
Wei XF; Department of hepatobiliary surgery, the first affiliated Hospital of Chongqing Medical University, Chongqing, China. Electronic address: .
Wu ZJ; Department of hepatobiliary surgery, the first affiliated Hospital of Chongqing Medical University, Chongqing, China. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Jul 01; Vol. 276, pp. 119424. Date of Electronic Publication: 2021 Mar 27.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis*
Autophagy*
AMP-Activated Protein Kinases/*metabolism
Autophagy-Related Protein-1 Homolog/*metabolism
Interleukin-1/*metabolism
Liver Diseases/*prevention & control
Reperfusion Injury/*prevention & control
TOR Serine-Threonine Kinases/*metabolism
AMP-Activated Protein Kinases/genetics ; Animals ; Autophagy-Related Protein-1 Homolog/genetics ; Gene Expression Regulation ; Interleukin-1/genetics ; Liver Diseases/etiology ; Liver Diseases/metabolism ; Liver Diseases/pathology ; Male ; Mice ; Mice, Inbred C57BL ; Phosphorylation ; Reperfusion Injury/etiology ; Reperfusion Injury/metabolism ; Reperfusion Injury/pathology ; Signal Transduction ; TOR Serine-Threonine Kinases/genetics
Czasopismo naukowe
Tytuł :
iCAL: a new pipeline to investigate autophagy selectivity and cancer.
Autorzy :
Zhang W; Key Laboratory of Molecular Biophysics of Ministry of Education, Hubei Bioinformatics and Molecular Imaging Key Laboratory, Center for Artificial Intelligence Biology, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Han Z; Key Laboratory of Birth Defects and Related Diseases of Women and Children, Department of Paediatrics, West China Second University Hospital, State Key Laboratory of Biotherapy and Collaborative Innovation Center of Biotherapy, Sichuan University, Chengdu, China.
Xue Y; Key Laboratory of Molecular Biophysics of Ministry of Education, Hubei Bioinformatics and Molecular Imaging Key Laboratory, Center for Artificial Intelligence Biology, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Jia D; Key Laboratory of Birth Defects and Related Diseases of Women and Children, Department of Paediatrics, West China Second University Hospital, State Key Laboratory of Biotherapy and Collaborative Innovation Center of Biotherapy, Sichuan University, Chengdu, China.
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Źródło :
Autophagy [Autophagy] 2021 Jul; Vol. 17 (7), pp. 1799-1801. Date of Electronic Publication: 2021 Jun 28.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Comment
MeSH Terms :
Autophagy*
Neoplasms*/genetics
Autophagy-Related Protein 8 Family ; Histocompatibility Antigens ; Histone-Lysine N-Methyltransferase ; Humans ; Macroautophagy ; Microtubule-Associated Proteins
Czasopismo naukowe
Tytuł :
Screening and identification of autophagy-related biomarkers for oral squamous cell carcinoma (OSCC) via integrated bioinformatics analysis.
Autorzy :
Huang GZ; Department of Oral & Maxillofacial Surgery, NanFang Hospital, Southern Medical University, Guangzhou, China.
Lu ZY; Department of Oral & Maxillofacial Surgery, NanFang Hospital, Southern Medical University, Guangzhou, China.
Rao Y; Department of Oral & Maxillofacial Surgery, NanFang Hospital, Southern Medical University, Guangzhou, China.
Gao H; Department of Prosthodontics, Stomatological Hospital, Southern Medical University, Guangzhou, China.
Lv XZ; Department of Oral & Maxillofacial Surgery, NanFang Hospital, Southern Medical University, Guangzhou, China.
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Źródło :
Journal of cellular and molecular medicine [J Cell Mol Med] 2021 May; Vol. 25 (9), pp. 4444-4454. Date of Electronic Publication: 2021 Apr 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Autophagy*
Gene Expression Regulation, Neoplastic*
Autophagy-Related Proteins/*genetics
Biomarkers, Tumor/*genetics
Carcinoma, Squamous Cell/*pathology
Computational Biology/*methods
Mouth Neoplasms/*pathology
Apoptosis ; Autophagy-Related Proteins/metabolism ; Biomarkers, Tumor/metabolism ; Carcinoma, Squamous Cell/genetics ; Carcinoma, Squamous Cell/metabolism ; Cell Proliferation ; Female ; Gene Expression Profiling ; Gene Ontology ; Gene Regulatory Networks ; Humans ; Middle Aged ; Mouth Neoplasms/genetics ; Mouth Neoplasms/metabolism ; Prognosis ; Survival Rate ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
Autophagy contributes to angiotensin II induced dysfunction of HUVECs.
Autorzy :
Liu D; Department of Physiology and Neuroscience, Soochow University - Dushu Lake Campus, Suzhou, China.
Sun WP; Department of Pharmacology and Laboratory of Aging and Nervous Diseases, Soochow University School of Pharmaceutical Science, Laboratory of Molecular Diagnostics, Medical College of Soochow University, Suzhou, P.R. China.
Chen JW; Department of Internal Medicine, the Affiliated Suzhou Chinese Traditional Medicine Hospital, Nanjing University of Chinese Medicine, Suzhou, P.R. China.
Jiang Y; Department of Physiology and Neuroscience, Soochow University - Dushu Lake Campus, Suzhou, China.
Xue R; Department of Physiology and Neuroscience, Soochow University - Dushu Lake Campus, Suzhou, China.
Wang LH; Department of Physiology and Neuroscience, Soochow University - Dushu Lake Campus, Suzhou, China.
Murao K; Department of Clinical Laboratory, Faculty of Medicine, Kagawa University, Kagawa, Japan.
Zhang GX; Department of Physiology and Neuroscience, Soochow University - Dushu Lake Campus, Suzhou, China.
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Źródło :
Clinical and experimental hypertension (New York, N.Y. : 1993) [Clin Exp Hypertens] 2021 Jul 04; Vol. 43 (5), pp. 462-473. Date of Electronic Publication: 2021 Mar 29.
Typ publikacji :
Journal Article
MeSH Terms :
Autophagy*/drug effects
Angiotensin II/*toxicity
Human Umbilical Vein Endothelial Cells/*pathology
Acetophenones/pharmacology ; Adenine/analogs & derivatives ; Adenine/pharmacology ; Animals ; Autophagosomes/drug effects ; Autophagosomes/metabolism ; Autophagy-Related Proteins/metabolism ; Benzimidazoles/pharmacology ; Biphenyl Compounds/pharmacology ; Decanoic Acids/pharmacology ; Human Umbilical Vein Endothelial Cells/drug effects ; Humans ; Hydroxy Acids/pharmacology ; Models, Biological ; NG-Nitroarginine Methyl Ester/pharmacology ; Nitric Oxide/metabolism ; Nitric Oxide Synthase Type III/metabolism ; Phosphorylation/drug effects ; Signal Transduction/drug effects ; Sirolimus/pharmacology ; Tetrazoles/pharmacology ; Time Factors
Czasopismo naukowe
Tytuł :
A unique COPII population in plant autophagy.
Autorzy :
Zeng Y; School of Life Sciences, Centre for Cell & Developmental Biology and State Key Laboratory of Agrobiotechnology, The Chinese University of Hong Kong, Hong Kong, China.
Jiang L; School of Life Sciences, Centre for Cell & Developmental Biology and State Key Laboratory of Agrobiotechnology, The Chinese University of Hong Kong, Hong Kong, China.; CUHK Shenzhen Research Institute, Shenzhen, China.; Institute of Plant Molecular Biology and Agricultural Biotechnology, The Chinese University of Hong Kong, Hong Kong, China.
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Źródło :
Autophagy [Autophagy] 2021 Jul; Vol. 17 (7), pp. 1785-1787. Date of Electronic Publication: 2021 May 28.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Comment
MeSH Terms :
Autophagy*
Saccharomyces cerevisiae Proteins*
Autophagosomes ; Autophagy-Related Proteins ; Proteomics
Czasopismo naukowe
Tytuł :
Cellular FADD-like IL-1β-converting enzyme-inhibitory protein attenuates myocardial ischemia/reperfusion injury via suppressing apoptosis and autophagy simultaneously.
Autorzy :
Liu D; Institute of Cardiovascular Disease, China Three Gorges University, Yichang, 443003, China; Department of Cardiology, Yichang Central People's Hospital, Yichang, 443003, China; HuBei Clinical Research Center for Ischemic Cardiovascular Disease, Yichang, 443003, China.
Wu H; Institute of Cardiovascular Disease, China Three Gorges University, Yichang, 443003, China; Department of Cardiology, Yichang Central People's Hospital, Yichang, 443003, China; HuBei Clinical Research Center for Ischemic Cardiovascular Disease, Yichang, 443003, China. Electronic address: .
Li YZ; Institute of Cardiovascular Disease, China Three Gorges University, Yichang, 443003, China; Department of Cardiology, Yichang Central People's Hospital, Yichang, 443003, China; HuBei Clinical Research Center for Ischemic Cardiovascular Disease, Yichang, 443003, China.
Yang J; Institute of Cardiovascular Disease, China Three Gorges University, Yichang, 443003, China; Department of Cardiology, Yichang Central People's Hospital, Yichang, 443003, China; HuBei Clinical Research Center for Ischemic Cardiovascular Disease, Yichang, 443003, China.
Yang J; Institute of Cardiovascular Disease, China Three Gorges University, Yichang, 443003, China.
Ding JW; Institute of Cardiovascular Disease, China Three Gorges University, Yichang, 443003, China; Department of Cardiology, Yichang Central People's Hospital, Yichang, 443003, China; HuBei Clinical Research Center for Ischemic Cardiovascular Disease, Yichang, 443003, China.
Zhou G; Institute of Cardiovascular Disease, China Three Gorges University, Yichang, 443003, China; Department of Cardiology, Yichang Central People's Hospital, Yichang, 443003, China; HuBei Clinical Research Center for Ischemic Cardiovascular Disease, Yichang, 443003, China.
Zhang J; Department of Cardiology, Yichang Central People's Hospital, Yichang, 443003, China; HuBei Clinical Research Center for Ischemic Cardiovascular Disease, Yichang, 443003, China; Department of Central Experimental Laboratory, Yichang Central People's Hospital, Yichang, 443003, China.
Wang X; Institute of Cardiovascular Disease, China Three Gorges University, Yichang, 443003, China; Department of Cardiology, Yichang Central People's Hospital, Yichang, 443003, China; HuBei Clinical Research Center for Ischemic Cardiovascular Disease, Yichang, 443003, China.
Fan ZX; Institute of Cardiovascular Disease, China Three Gorges University, Yichang, 443003, China.
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Źródło :
Nutrition, metabolism, and cardiovascular diseases : NMCD [Nutr Metab Cardiovasc Dis] 2021 Jun 07; Vol. 31 (6), pp. 1916-1928. Date of Electronic Publication: 2021 Mar 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis*
Autophagy*
CASP8 and FADD-Like Apoptosis Regulating Protein/*metabolism
Myocardial Infarction/*prevention & control
Myocardial Reperfusion Injury/*prevention & control
Myocytes, Cardiac/*metabolism
Animals ; Apoptosis Regulatory Proteins/metabolism ; Autophagy-Related Proteins/metabolism ; CASP8 and FADD-Like Apoptosis Regulating Protein/genetics ; Cells, Cultured ; Disease Models, Animal ; Male ; Myocardial Infarction/metabolism ; Myocardial Infarction/pathology ; Myocardial Reperfusion Injury/genetics ; Myocardial Reperfusion Injury/metabolism ; Myocardial Reperfusion Injury/pathology ; Myocytes, Cardiac/pathology ; NF-kappa B/metabolism ; Rats, Sprague-Dawley ; Signal Transduction ; Up-Regulation
Czasopismo naukowe
Tytuł :
Age-related defects in autophagy alter the secretion of paracrine factors from bone marrow mononuclear cells.
Autorzy :
Yeganeh A; Toronto General Hospital Research Institute, University Health Network, Toronto, Canada.
Alibhai FJ; Toronto General Hospital Research Institute, University Health Network, Toronto, Canada.
Tobin SW; Toronto General Hospital Research Institute, University Health Network, Toronto, Canada.
Lim F; Toronto General Hospital Research Institute, University Health Network, Toronto, Canada.
Wu J; Toronto General Hospital Research Institute, University Health Network, Toronto, Canada.
Li S; Toronto General Hospital Research Institute, University Health Network, Toronto, Canada.
Weisel RD; Toronto General Hospital Research Institute, University Health Network, Toronto, Canada.; Department of Surgery, Division of Cardiac Surgery, University of Toronto, Toronto, Canada.
Li RK; Toronto General Hospital Research Institute, University Health Network, Toronto, Canada.; Department of Surgery, Division of Cardiac Surgery, University of Toronto, Toronto, Canada.
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Źródło :
Aging [Aging (Albany NY)] 2021 Jun 04; Vol. 13 (11), pp. 14687-14708. Date of Electronic Publication: 2021 Jun 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Autophagy*/drug effects
Paracrine Communication*/drug effects
Aging/*pathology
Bone Marrow Cells/*metabolism
Leukocytes, Mononuclear/*metabolism
Animals ; Antigens, Ly/metabolism ; Autophagy-Related Protein 7/metabolism ; Culture Media, Conditioned/pharmacology ; Extracellular Vesicles/drug effects ; Extracellular Vesicles/metabolism ; Fibroblasts/drug effects ; Fibroblasts/metabolism ; Leukocytes, Mononuclear/drug effects ; Membrane Proteins/metabolism ; Mice, Inbred C57BL ; Myocardium/pathology ; Transforming Growth Factor beta1/pharmacology
Czasopismo naukowe
Tytuł :
The role of autophagy in human cytomegalovirus IE2 expression.
Autorzy :
Zhang X; Department of Pediatrics, Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei, China.
Xi T; Department of Pediatrics, Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei, China.
Zhang L; Department of Pediatrics, Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei, China.
Bi Y; Department of Pediatrics, Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei, China.
Huang Y; Department of Pediatrics, Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei, China.
Lu Y; Department of Pediatrics, Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei, China.
Liu X; Department of Pediatrics, Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei, China.
Fang F; Department of Pediatrics, Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei, China.
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Źródło :
Journal of medical virology [J Med Virol] 2021 Jun; Vol. 93 (6), pp. 3795-3803. Date of Electronic Publication: 2020 Oct 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Autophagy*
Cytomegalovirus/*genetics
Immediate-Early Proteins/*genetics
Trans-Activators/*genetics
Autophagy-Related Proteins/genetics ; Cells, Cultured ; Cytomegalovirus/pathogenicity ; Fibroblasts/virology ; Gene Expression Regulation ; Host-Pathogen Interactions ; Humans ; Lung/cytology ; Ubiquitin-Conjugating Enzymes/genetics ; Virus Replication
Czasopismo naukowe
Tytuł :
The role of autophagy in bone homeostasis.
Autorzy :
Guo YF; Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, Hunan, China.
Su T; Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, Hunan, China.
Yang M; Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, Hunan, China.
Li CJ; Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, Hunan, China.
Guo Q; Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, Hunan, China.
Xiao Y; Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, Hunan, China.
Huang Y; Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, Hunan, China.
Liu Y; Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, Hunan, China.
Luo XH; Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, Hunan, China.; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital of Central South University, Changsha, Hunan, China.
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Źródło :
Journal of cellular physiology [J Cell Physiol] 2021 Jun; Vol. 236 (6), pp. 4152-4173. Date of Electronic Publication: 2021 Jan 16.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Autophagy*/drug effects
Bone Remodeling*/drug effects
Bone and Bones/*pathology
Osteitis Deformans/*pathology
Osteoarthritis/*pathology
Osteoporosis/*pathology
Animals ; Autophagy-Related Proteins/metabolism ; Bone Density Conservation Agents/therapeutic use ; Bone and Bones/drug effects ; Bone and Bones/metabolism ; Bone and Bones/physiopathology ; Homeostasis ; Humans ; Osteitis Deformans/drug therapy ; Osteitis Deformans/metabolism ; Osteitis Deformans/physiopathology ; Osteoarthritis/drug therapy ; Osteoarthritis/metabolism ; Osteoarthritis/physiopathology ; Osteoporosis/drug therapy ; Osteoporosis/metabolism ; Osteoporosis/physiopathology
Czasopismo naukowe
Tytuł :
Circulating mitochondrial DNA-triggered autophagy dysfunction via STING underlies sepsis-related acute lung injury.
Autorzy :
Liu Q; Research Institute of General Surgery, Jinling Hospital, Medical school of Nanjing University, Nanjing, China.
Wu J; Department of General Surgery, The Affiliated BenQ Hospital of Nanjing Medical University, Nanjing, China.
Zhang X; Research Institute of General Surgery, Jinling Hospital, School of Medicine, Southeast University, Nanjing, China.
Li X; Research Institute of General Surgery, Jinling Hospital, Nanjing Medical University, Nanjing, China.
Wu X; Research Institute of General Surgery, Jinling Hospital, Nanjing, China. .
Zhao Y; Department of General Surgery, The Affiliated BenQ Hospital of Nanjing Medical University, Nanjing, China. .
Ren J; Research Institute of General Surgery, Jinling Hospital, Medical school of Nanjing University, Nanjing, China. .; Research Institute of General Surgery, Jinling Hospital, School of Medicine, Southeast University, Nanjing, China. .; Research Institute of General Surgery, Jinling Hospital, Nanjing Medical University, Nanjing, China. .; Research Institute of General Surgery, Jinling Hospital, Nanjing, China. .
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Źródło :
Cell death & disease [Cell Death Dis] 2021 Jul 03; Vol. 12 (7), pp. 673. Date of Electronic Publication: 2021 Jul 03.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Autophagy*
Acute Lung Injury/*metabolism
Cell-Free Nucleic Acids/*blood
DNA, Mitochondrial/*blood
Lung/*metabolism
Membrane Proteins/*metabolism
Sepsis/*complications
Acute Lung Injury/etiology ; Acute Lung Injury/genetics ; Acute Lung Injury/pathology ; Animals ; Autophagy-Related Proteins/metabolism ; Cell-Free Nucleic Acids/genetics ; DNA, Mitochondrial/genetics ; Disease Models, Animal ; Humans ; Hydrogen-Ion Concentration ; Inflammation Mediators/metabolism ; Interferons/metabolism ; Lung/pathology ; Lysosomes/genetics ; Lysosomes/metabolism ; Lysosomes/pathology ; Membrane Proteins/genetics ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; RAW 264.7 Cells ; Sepsis/microbiology
Czasopismo naukowe
Tytuł :
Coxsackievirus infection induces a non-canonical autophagy independent of the ULK and PI3K complexes.
Autorzy :
Mohamud Y; Centre for Heart Lung Innovation, St. Paul's Hospital, 1081 Burrard St., Vancouver, BC, V6Z 1Y6, Canada.; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada.
Shi J; Centre for Heart Lung Innovation, St. Paul's Hospital, 1081 Burrard St., Vancouver, BC, V6Z 1Y6, Canada.; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada.
Tang H; Centre for Heart Lung Innovation, St. Paul's Hospital, 1081 Burrard St., Vancouver, BC, V6Z 1Y6, Canada.; Department of Pharmacy, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, People's Republic of China.
Xiang P; Centre for Heart Lung Innovation, St. Paul's Hospital, 1081 Burrard St., Vancouver, BC, V6Z 1Y6, Canada.; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada.
Xue YC; Centre for Heart Lung Innovation, St. Paul's Hospital, 1081 Burrard St., Vancouver, BC, V6Z 1Y6, Canada.; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada.
Liu H; Centre for Heart Lung Innovation, St. Paul's Hospital, 1081 Burrard St., Vancouver, BC, V6Z 1Y6, Canada.; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada.
Ng CS; Centre for Heart Lung Innovation, St. Paul's Hospital, 1081 Burrard St., Vancouver, BC, V6Z 1Y6, Canada.; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada.
Luo H; Centre for Heart Lung Innovation, St. Paul's Hospital, 1081 Burrard St., Vancouver, BC, V6Z 1Y6, Canada. .; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada. .
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Źródło :
Scientific reports [Sci Rep] 2020 Nov 04; Vol. 10 (1), pp. 19068. Date of Electronic Publication: 2020 Nov 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Autophagy*
Autophagy-Related Protein-1 Homolog/*metabolism
Coxsackievirus Infections/*metabolism
Intracellular Signaling Peptides and Proteins/*metabolism
Phosphatidylinositol 3-Kinases/*metabolism
Protein-Serine-Threonine Kinases/*metabolism
Autophagy-Related Proteins/metabolism ; HEK293 Cells ; HeLa Cells ; Humans ; Membrane Proteins/metabolism ; Phosphate-Binding Proteins/metabolism ; Phosphotransferases (Alcohol Group Acceptor)/metabolism ; Viral Proteases/metabolism
Czasopismo naukowe

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