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Wyszukujesz frazę ""beta-Lactamase Inhibitors"" wg kryterium: Temat


Tytuł :
Pharmacokinetic/pharmacodynamic target attainment in critically ill renal patients on antimicrobial usage: focus on novel beta-lactams and beta lactams/beta-lactamase inhibitors.
Autorzy :
Gatti M; Department of Medical and Surgical Sciences, Alma Mater Studiorum, University of Bologna, Bologna, Italy.; SSD Clinical Pharmacology, University Hospital IRCCS Policlinico Sant'Orsola, Bologna, Italy.
Pea F; Department of Medical and Surgical Sciences, Alma Mater Studiorum, University of Bologna, Bologna, Italy.; SSD Clinical Pharmacology, University Hospital IRCCS Policlinico Sant'Orsola, Bologna, Italy.
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Źródło :
Expert review of clinical pharmacology [Expert Rev Clin Pharmacol] 2021 May; Vol. 14 (5), pp. 583-599. Date of Electronic Publication: 2021 Apr 29.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Bacterial Infections/*drug therapy
beta-Lactamase Inhibitors/*administration & dosage
beta-Lactams/*administration & dosage
Bacterial Infections/microbiology ; Critical Illness ; Dose-Response Relationship, Drug ; Drug Development ; Drug Monitoring ; Drug Resistance, Multiple, Bacterial ; Humans ; Kidney Diseases/complications ; Kidney Diseases/physiopathology ; beta-Lactamase Inhibitors/pharmacokinetics ; beta-Lactamase Inhibitors/pharmacology ; beta-Lactams/pharmacokinetics ; beta-Lactams/pharmacology
Czasopismo naukowe
Tytuł :
Activity of β-Lactam Antibiotics against Metallo-β-Lactamase-Producing Enterobacterales in Animal Infection Models: a Current State of Affairs.
Autorzy :
Asempa TE; Center for Anti-Infective Research and Development, Hartford Hospital, Hartford, Connecticut, USA.
Abdelraouf K; Center for Anti-Infective Research and Development, Hartford Hospital, Hartford, Connecticut, USA.
Nicolau DP; Center for Anti-Infective Research and Development, Hartford Hospital, Hartford, Connecticut, USA .; Division of Infectious Diseases, Hartford Hospital, Hartford, Connecticut, USA.
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Źródło :
Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2021 May 18; Vol. 65 (6). Date of Electronic Publication: 2021 May 18 (Print Publication: 2021).
Typ publikacji :
Journal Article; Review
MeSH Terms :
beta-Lactamase Inhibitors*
beta-Lactamases*/genetics
Animals ; Anti-Bacterial Agents/pharmacology ; Humans ; Monobactams ; beta-Lactams/pharmacology
Czasopismo naukowe
Tytuł :
Discovery of beta-lactamase CMY-10 inhibitors for combination therapy against multi-drug resistant Enterobacteriaceae.
Autorzy :
Parvaiz N; Computational Biology Lab, National Center for Bioinformatics, Quaid-i-Azam University, Islamabad, Pakistan.
Ahmad F; Computational Biology Lab, National Center for Bioinformatics, Quaid-i-Azam University, Islamabad, Pakistan.
Yu W; University of Maryland Computer-Aided Drug Design Center, Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, MD, United States of America.
MacKerell AD Jr; University of Maryland Computer-Aided Drug Design Center, Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, MD, United States of America.
Azam SS; Computational Biology Lab, National Center for Bioinformatics, Quaid-i-Azam University, Islamabad, Pakistan.
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Źródło :
PloS one [PLoS One] 2021 Jan 15; Vol. 16 (1), pp. e0244967. Date of Electronic Publication: 2021 Jan 15 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Enterobacteriaceae Infections/*drug therapy
beta-Lactamase Inhibitors/*therapeutic use
beta-Lactamases/*drug effects
Binding Sites ; Drug Discovery ; Drug Evaluation, Preclinical/methods ; Drug Resistance, Multiple, Bacterial ; Drug Therapy, Combination ; Humans ; Machine Learning ; Microbial Sensitivity Tests ; Microscopy, Electron, Scanning ; beta-Lactamase Inhibitors/administration & dosage
Czasopismo naukowe
Tytuł :
Fluorogenic Probes/Inhibitors of β-Lactamase and their Applications in Drug-Resistant Bacteria.
Autorzy :
Ding Y; Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM), Nanjing Tech University (NanjingTech), Nanjing, 211816, P. R. China.
Li Z; Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM), Nanjing Tech University (NanjingTech), Nanjing, 211816, P. R. China.
Xu C; Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM), Nanjing Tech University (NanjingTech), Nanjing, 211816, P. R. China.
Qin W; Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM), Nanjing Tech University (NanjingTech), Nanjing, 211816, P. R. China.
Wu Q; Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM), Nanjing Tech University (NanjingTech), Nanjing, 211816, P. R. China.
Wang X; College of Chemistry and Material Engineering, University of Science and Technology of Anhui, Bengbu, 233000, P. R. China.
Cheng X; Institute of Advanced Synthesis, School of Chemistry and Molecular Engineering, Nanjing Tech University (NanjingTech), Nanjing, 211816, P. R. China.
Li L; Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM), Nanjing Tech University (NanjingTech), Nanjing, 211816, P. R. China.
Huang W; Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM), Nanjing Tech University (NanjingTech), Nanjing, 211816, P. R. China.; Frontiers Science Center for Flexible Electronics (FSCFE), Shaanxi Institute of Flexible Electronics (SIFE) & Shaanxi Institute of Biomedical Materials and Engineering (SIBME), Northwestern Polytechnical University (NPU), Xi'an, 710072, P. R. China.
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Źródło :
Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2021 Jan 04; Vol. 60 (1), pp. 24-40. Date of Electronic Publication: 2020 Aug 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Bacteria/*drug effects
Drug Resistance, Bacterial/*drug effects
Fluorescent Dyes/*therapeutic use
beta-Lactam Resistance/*drug effects
beta-Lactamase Inhibitors/*therapeutic use
Humans ; beta-Lactamase Inhibitors/pharmacology
Czasopismo naukowe
Tytuł :
Deciphering molecular mechanism behind conformational change of the São Paolo metallo-β-lactamase 1 by using enhanced sampling.
Autorzy :
Chen J; School of Science, Shandong Jiaotong University, Jinan, China.
Wang J; Drug Discovery and Design Center, CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Pang L; School of Science, Shandong Jiaotong University, Jinan, China.
Wang W; School of Science, Shandong Jiaotong University, Jinan, China.
Zhao J; School of Science, Shandong Jiaotong University, Jinan, China.
Zhu W; Drug Discovery and Design Center, CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
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Źródło :
Journal of biomolecular structure & dynamics [J Biomol Struct Dyn] 2021 Jan; Vol. 39 (1), pp. 140-151. Date of Electronic Publication: 2019 Dec 28.
Typ publikacji :
Journal Article
MeSH Terms :
beta-Lactamase Inhibitors*
beta-Lactamases*/metabolism
Molecular Conformation ; Molecular Dynamics Simulation ; Zinc
Czasopismo naukowe
Tytuł :
New Carbapenemase Inhibitors: Clearing the Way for the β-Lactams.
Autorzy :
Vázquez-Ucha JC; Servicio de Microbiología, Instituto de Investigación Biomédica de A Coruña (INIBIC-CICA), Complejo Hospitalario Universitario A Coruña (CHUAC), As Xubias 84, 15006 A Coruña, Spain.
Arca-Suárez J; Servicio de Microbiología, Instituto de Investigación Biomédica de A Coruña (INIBIC-CICA), Complejo Hospitalario Universitario A Coruña (CHUAC), As Xubias 84, 15006 A Coruña, Spain.
Bou G; Servicio de Microbiología, Instituto de Investigación Biomédica de A Coruña (INIBIC-CICA), Complejo Hospitalario Universitario A Coruña (CHUAC), As Xubias 84, 15006 A Coruña, Spain.
Beceiro A; Servicio de Microbiología, Instituto de Investigación Biomédica de A Coruña (INIBIC-CICA), Complejo Hospitalario Universitario A Coruña (CHUAC), As Xubias 84, 15006 A Coruña, Spain.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Dec 06; Vol. 21 (23). Date of Electronic Publication: 2020 Dec 06.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Drug Development*
Bacterial Infections/*drug therapy
Bacterial Proteins/*antagonists & inhibitors
Carbapenems/*pharmacology
beta-Lactamase Inhibitors/*pharmacology
Carbapenems/chemistry ; Carbapenems/therapeutic use ; Drug Resistance, Bacterial ; Humans ; beta-Lactamase Inhibitors/chemistry ; beta-Lactamase Inhibitors/therapeutic use ; beta-Lactamases
Czasopismo naukowe
Tytuł :
Design, synthesis, biological evaluation and in silico studies of certain aryl sulfonyl hydrazones conjugated with 1,3-diaryl pyrazoles as potent metallo-β-lactamase inhibitors.
Autorzy :
Shaaban MM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria 21521, Egypt.
Ragab HM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria 21521, Egypt.
Akaji K; Department of Medicinal Chemistry, Kyoto Pharmaceutical University, Japan.
McGeary RP; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD 4072, Australia.
Bekhit AA; Food Sciences, University of Otago, Dunedin, New Zealand.
Hussein WM; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD 4072, Australia; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Helwan University, Ein Helwan, Helwan, Egypt.
Kurz JL; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD 4072, Australia.
Elwakil BH; Department of Medical Laboratory Technology, Faculty of Allied Medical Science, Pharos University in Alexandria, Egypt.
Bekhit SA; High Institute of Public Health, Alexandria University, Alexandria 21568, Egypt.
Ibrahim TM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh 33516, Egypt. Electronic address: .
Mahran MA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria 21521, Egypt.
Bekhit AA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria 21521, Egypt; Cancer Nanotechnology Research Laboratory (CNRL), Faculty of Pharmacy, Alexandria University, Alexandria 21521, Egypt; Pharmacy Program, Allied Health Department, College of Health and Sport Sciences, University of Bahrain, P.O. Box 32038, Bahrain. Electronic address: .
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Źródło :
Bioorganic chemistry [Bioorg Chem] 2020 Dec; Vol. 105, pp. 104386. Date of Electronic Publication: 2020 Oct 20.
Typ publikacji :
Journal Article
MeSH Terms :
Anti-Bacterial Agents/*pharmacology
Hydrazones/*pharmacology
Klebsiella pneumoniae/*drug effects
Pyrazoles/*pharmacology
beta-Lactamase Inhibitors/*pharmacology
beta-Lactamases/*metabolism
Anti-Bacterial Agents/chemical synthesis ; Anti-Bacterial Agents/chemistry ; Dose-Response Relationship, Drug ; Drug Design ; Drug Resistance, Bacterial/drug effects ; Hydrazones/chemical synthesis ; Hydrazones/chemistry ; Klebsiella pneumoniae/enzymology ; Microbial Sensitivity Tests ; Molecular Docking Simulation ; Molecular Structure ; Pyrazoles/chemistry ; Structure-Activity Relationship ; beta-Lactamase Inhibitors/chemical synthesis ; beta-Lactamase Inhibitors/chemistry
Czasopismo naukowe
Tytuł :
Hydroxamic acid with benzenesulfonamide: An effective scaffold for the development of broad-spectrum metallo-β-lactamase inhibitors.
Autorzy :
Li JQ; Key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education, College of Chemistry and Materials Science, Northwest University, Xi'an 710127, PR China.
Chen C; Key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education, College of Chemistry and Materials Science, Northwest University, Xi'an 710127, PR China.
Yao M; Key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education, College of Chemistry and Materials Science, Northwest University, Xi'an 710127, PR China.
Sun LY; Key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education, College of Chemistry and Materials Science, Northwest University, Xi'an 710127, PR China.
Gao H; Key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education, College of Chemistry and Materials Science, Northwest University, Xi'an 710127, PR China.
Chigan J; Key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education, College of Chemistry and Materials Science, Northwest University, Xi'an 710127, PR China.
Yang KW; Key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education, College of Chemistry and Materials Science, Northwest University, Xi'an 710127, PR China. Electronic address: .
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Źródło :
Bioorganic chemistry [Bioorg Chem] 2020 Dec; Vol. 105, pp. 104436. Date of Electronic Publication: 2020 Oct 29.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Development*
Hydroxamic Acids/*pharmacology
Sulfonamides/*pharmacology
beta-Lactamase Inhibitors/*pharmacology
beta-Lactamases/*metabolism
Animals ; Cells, Cultured ; Dose-Response Relationship, Drug ; Hydroxamic Acids/chemistry ; Mice ; Molecular Docking Simulation ; Molecular Structure ; Structure-Activity Relationship ; Sulfonamides/chemistry ; beta-Lactamase Inhibitors/chemical synthesis ; beta-Lactamase Inhibitors/chemistry
Czasopismo naukowe
Tytuł :
Discovery of an Orally Available Diazabicyclooctane Inhibitor (ETX0282) of Class A, C, and D Serine β-Lactamases.
Autorzy :
Durand-Réville TF; Entasis Therapeutics, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States.
Comita-Prevoir J; Entasis Therapeutics, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States.
Zhang J; Entasis Therapeutics, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States.
Wu X; Entasis Therapeutics, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States.
May-Dracka TL; Infection Discovery, AstraZeneca R&D Boston, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States.
Romero JAC; Entasis Therapeutics, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States.
Wu F; Entasis Therapeutics, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States.
Chen A; Entasis Therapeutics, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States.
Shapiro AB; Entasis Therapeutics, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States.
Carter NM; Entasis Therapeutics, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States.
McLeod SM; Entasis Therapeutics, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States.
Giacobbe RA; Infection Discovery, AstraZeneca R&D Boston, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States.
Verheijen JC; Infection Discovery, AstraZeneca R&D Boston, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States.
Lahiri SD; Infection Discovery, AstraZeneca R&D Boston, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States.
Sacco MD; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, 12901 Bruce B. Downs Boulevard, Tampa, Florida 33612, United States.
Chen Y; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, 12901 Bruce B. Downs Boulevard, Tampa, Florida 33612, United States.
O'Donnell JP; Entasis Therapeutics, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States.
Miller AA; Entasis Therapeutics, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States.
Mueller JP; Entasis Therapeutics, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States.
Tommasi RA; Entasis Therapeutics, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2020 Nov 12; Vol. 63 (21), pp. 12511-12525. Date of Electronic Publication: 2020 Jul 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Anti-Bacterial Agents/*chemistry
Azabicyclo Compounds/*chemistry
beta-Lactamase Inhibitors/*chemistry
beta-Lactamases/*chemistry
Administration, Oral ; Animals ; Anti-Bacterial Agents/pharmacokinetics ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Azabicyclo Compounds/metabolism ; Azabicyclo Compounds/pharmacology ; Azabicyclo Compounds/therapeutic use ; Drug Design ; Drug Evaluation, Preclinical ; Gram-Negative Bacteria/drug effects ; Gram-Positive Bacteria/drug effects ; Half-Life ; Humans ; Mice ; Microbial Sensitivity Tests ; Penicillin-Binding Proteins/chemistry ; Penicillin-Binding Proteins/metabolism ; Prodrugs/chemistry ; Prodrugs/metabolism ; Protein Binding ; Rats ; Skin Diseases/drug therapy ; Skin Diseases/pathology ; Skin Diseases/veterinary ; Structure-Activity Relationship ; beta-Lactamase Inhibitors/metabolism ; beta-Lactamase Inhibitors/pharmacology ; beta-Lactamase Inhibitors/therapeutic use ; beta-Lactamases/metabolism
Czasopismo naukowe
Tytuł :
α-Triazolylboronic Acids: A Promising Scaffold for Effective Inhibitors of KPCs.
Autorzy :
Introvigne ML; Clinical and Experimental Medicine PhD Programme, University of Modena and Reggio Emilia, via Università 4, 41121, Modena, Italy.; Department of Life Sciences, University of Modena and Reggio Emilia, Via Campi 103, 41125, Modena, Italy.
Taracila MA; Departments of Medicine.; Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, OH 44106, USA.
Prati F; Department of Life Sciences, University of Modena and Reggio Emilia, Via Campi 103, 41125, Modena, Italy.
Caselli E; Department of Life Sciences, University of Modena and Reggio Emilia, Via Campi 103, 41125, Modena, Italy.
Bonomo RA; Departments of Medicine.; Pharmacology, Biochemistry and Molecular Biology and Microbiology, Biochemistry, and Proteomics and Bioinformatics, Case Western Reserve University, 2109 Adelbert Rd., Cleveland, OH 44106, USA.; Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, OH 44106, USA.; CWRU-Cleveland VAMC Center for Antimicrobial Resistance and Epidemiology (Case VA CARES), Cleveland, OH 44106, USA.
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Źródło :
ChemMedChem [ChemMedChem] 2020 Jul 20; Vol. 15 (14), pp. 1283-1288. Date of Electronic Publication: 2020 Jun 22.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Anti-Bacterial Agents/*pharmacology
Bacterial Proteins/*antagonists & inhibitors
Boronic Acids/*pharmacology
Klebsiella pneumoniae/*drug effects
Triazoles/*pharmacology
beta-Lactamase Inhibitors/*pharmacology
Anti-Bacterial Agents/chemical synthesis ; Anti-Bacterial Agents/chemistry ; Bacterial Proteins/isolation & purification ; Bacterial Proteins/metabolism ; Boronic Acids/chemical synthesis ; Boronic Acids/chemistry ; Dose-Response Relationship, Drug ; Klebsiella pneumoniae/enzymology ; Microbial Sensitivity Tests ; Molecular Structure ; Structure-Activity Relationship ; Triazoles/chemical synthesis ; Triazoles/chemistry ; beta-Lactamase Inhibitors/chemical synthesis ; beta-Lactamase Inhibitors/chemistry ; beta-Lactamases/isolation & purification ; beta-Lactamases/metabolism
Czasopismo naukowe
Tytuł :
A 2018-2019 patent review of metallo beta-lactamase inhibitors.
Autorzy :
Reddy N; Catalysis and Peptide Research Unit, Westville Campus, University of KwaZulu-Natal , Durban, South Africa.
Shungube M; Catalysis and Peptide Research Unit, Westville Campus, University of KwaZulu-Natal , Durban, South Africa.
Arvidsson PI; Catalysis and Peptide Research Unit, Westville Campus, University of KwaZulu-Natal , Durban, South Africa.; Science for Life Laboratory, Karolinska Institutet , Stockhlom, Sweden.
Baijnath S; Catalysis and Peptide Research Unit, Westville Campus, University of KwaZulu-Natal , Durban, South Africa.
Kruger HG; Catalysis and Peptide Research Unit, Westville Campus, University of KwaZulu-Natal , Durban, South Africa.
Govender T; Department of Chemistry, University of Zululand , Empangeni, South Africa.
Naicker T; Catalysis and Peptide Research Unit, Westville Campus, University of KwaZulu-Natal , Durban, South Africa.
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Źródło :
Expert opinion on therapeutic patents [Expert Opin Ther Pat] 2020 Jul; Vol. 30 (7), pp. 541-555. Date of Electronic Publication: 2020 May 20.
Typ publikacji :
Journal Article; Review
MeSH Terms :
beta-Lactam Resistance/*drug effects
beta-Lactamase Inhibitors/*pharmacology
beta-Lactams/*pharmacology
Animals ; Anti-Bacterial Agents/administration & dosage ; Anti-Bacterial Agents/pharmacology ; Bacteria/drug effects ; Drug Development ; Drug Synergism ; Humans ; Patents as Topic ; beta-Lactamase Inhibitors/administration & dosage ; beta-Lactams/administration & dosage
Czasopismo naukowe
Tytuł :
Structural studies of triazole inhibitors with promising inhibitor effects against antibiotic resistance metallo-β-lactamases.
Autorzy :
Muhammad Z; Department of Chemistry, Faculty of Science and Technology, UiT The Arctic University of Norway, N-9037 Tromsø, Norway.
Skagseth S; The Norwegian Structural Biology Centre (NorStruct), Department of Chemistry, Faculty of Science and Technology, UiT The Arctic University of Norway, N-9037 Tromsø, Norway.
Boomgaren M; Department of Chemistry, Faculty of Science and Technology, UiT The Arctic University of Norway, N-9037 Tromsø, Norway.
Akhter S; Department of Chemistry, Faculty of Science and Technology, UiT The Arctic University of Norway, N-9037 Tromsø, Norway.
Fröhlich C; The Norwegian Structural Biology Centre (NorStruct), Department of Chemistry, Faculty of Science and Technology, UiT The Arctic University of Norway, N-9037 Tromsø, Norway.
Ismael A; Department of Chemistry, Faculty of Science and Technology, UiT The Arctic University of Norway, N-9037 Tromsø, Norway.
Christopeit T; The Norwegian Structural Biology Centre (NorStruct), Department of Chemistry, Faculty of Science and Technology, UiT The Arctic University of Norway, N-9037 Tromsø, Norway.
Bayer A; Department of Chemistry, Faculty of Science and Technology, UiT The Arctic University of Norway, N-9037 Tromsø, Norway. Electronic address: .
Leiros HS; The Norwegian Structural Biology Centre (NorStruct), Department of Chemistry, Faculty of Science and Technology, UiT The Arctic University of Norway, N-9037 Tromsø, Norway. Electronic address: .
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Źródło :
Bioorganic & medicinal chemistry [Bioorg Med Chem] 2020 Aug 01; Vol. 28 (15), pp. 115598. Date of Electronic Publication: 2020 Jun 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Triazoles/*pharmacology
beta-Lactam Resistance/*drug effects
beta-Lactamase Inhibitors/*pharmacology
Anti-Bacterial Agents/pharmacology ; Catalytic Domain ; Crystallography, X-Ray ; Drug Synergism ; Escherichia coli/drug effects ; Escherichia coli/enzymology ; Escherichia coli Proteins/metabolism ; Klebsiella pneumoniae/drug effects ; Meropenem/pharmacology ; Molecular Structure ; Protein Binding ; Pseudomonas aeruginosa/drug effects ; Pseudomonas aeruginosa/enzymology ; Small Molecule Libraries/chemical synthesis ; Small Molecule Libraries/metabolism ; Small Molecule Libraries/pharmacology ; Structure-Activity Relationship ; Triazoles/chemical synthesis ; Triazoles/metabolism ; beta-Lactamase Inhibitors/chemical synthesis ; beta-Lactamase Inhibitors/metabolism ; beta-Lactamases/metabolism
Czasopismo naukowe
Tytuł :
Discovery of Cyclic Boronic Acid QPX7728, an Ultrabroad-Spectrum Inhibitor of Serine and Metallo-β-lactamases.
Autorzy :
Hecker SJ; Qpex Biopharma, Inc., 6275 Nancy Ridge Drive, Suite 100, San Diego, California 92121, United States.
Reddy KR; Qpex Biopharma, Inc., 6275 Nancy Ridge Drive, Suite 100, San Diego, California 92121, United States.
Lomovskaya O; Qpex Biopharma, Inc., 6275 Nancy Ridge Drive, Suite 100, San Diego, California 92121, United States.
Griffith DC; Qpex Biopharma, Inc., 6275 Nancy Ridge Drive, Suite 100, San Diego, California 92121, United States.
Rubio-Aparicio D; Qpex Biopharma, Inc., 6275 Nancy Ridge Drive, Suite 100, San Diego, California 92121, United States.
Nelson K; Qpex Biopharma, Inc., 6275 Nancy Ridge Drive, Suite 100, San Diego, California 92121, United States.
Tsivkovski R; Qpex Biopharma, Inc., 6275 Nancy Ridge Drive, Suite 100, San Diego, California 92121, United States.
Sun D; Qpex Biopharma, Inc., 6275 Nancy Ridge Drive, Suite 100, San Diego, California 92121, United States.
Sabet M; Qpex Biopharma, Inc., 6275 Nancy Ridge Drive, Suite 100, San Diego, California 92121, United States.
Tarazi Z; Qpex Biopharma, Inc., 6275 Nancy Ridge Drive, Suite 100, San Diego, California 92121, United States.
Parkinson J; Qpex Biopharma, Inc., 6275 Nancy Ridge Drive, Suite 100, San Diego, California 92121, United States.
Totrov M; Molsoft LLC, 11199 Sorrento Valley Road, San Diego, California 92121, United States.
Boyer SH; Qpex Biopharma, Inc., 6275 Nancy Ridge Drive, Suite 100, San Diego, California 92121, United States.
Glinka TW; Qpex Biopharma, Inc., 6275 Nancy Ridge Drive, Suite 100, San Diego, California 92121, United States.
Pemberton OA; Department of Molecular Medicine, University of South Florida Morsani College of Medicine, 12901 Bruce B. Downs Boulevard, Tampa, Florida 33612, United States.
Chen Y; Department of Molecular Medicine, University of South Florida Morsani College of Medicine, 12901 Bruce B. Downs Boulevard, Tampa, Florida 33612, United States.
Dudley MN; Qpex Biopharma, Inc., 6275 Nancy Ridge Drive, Suite 100, San Diego, California 92121, United States.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2020 Jul 23; Vol. 63 (14), pp. 7491-7507. Date of Electronic Publication: 2020 Apr 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
MeSH Terms :
Borinic Acids/*pharmacology
Boronic Acids/*pharmacology
Carboxylic Acids/*pharmacology
beta-Lactamase Inhibitors/*pharmacology
Animals ; Bacteria/drug effects ; Borinic Acids/chemistry ; Borinic Acids/pharmacokinetics ; Borinic Acids/therapeutic use ; Boronic Acids/chemistry ; Boronic Acids/pharmacokinetics ; Boronic Acids/therapeutic use ; Carboxylic Acids/chemistry ; Carboxylic Acids/pharmacokinetics ; Carboxylic Acids/therapeutic use ; Drug Discovery ; Klebsiella Infections/drug therapy ; Mice ; Microbial Sensitivity Tests ; Structure-Activity Relationship ; beta-Lactamase Inhibitors/chemistry ; beta-Lactamase Inhibitors/pharmacokinetics ; beta-Lactamase Inhibitors/therapeutic use
Czasopismo naukowe
Tytuł :
Iminodiacetic Acid as a Novel Metal-Binding Pharmacophore for New Delhi Metallo-β-lactamase Inhibitor Development.
Autorzy :
Chen AY; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, 92093, USA.
Thomas CA; Department of Chemistry and Biochemistry, Miami University, Oxford, OH 45056, USA.
Thomas PW; Division of Chemical Biology & Medicinal Chemistry, College of Pharmacy, University of Texas, Austin, Austin, TX 78712, USA.
Yang K; Department of Chemistry and Biochemistry, Miami University, Oxford, OH 45056, USA.
Cheng Z; Department of Chemistry and Biochemistry, Miami University, Oxford, OH 45056, USA.
Fast W; Division of Chemical Biology & Medicinal Chemistry, College of Pharmacy, University of Texas, Austin, Austin, TX 78712, USA.
Crowder MW; Department of Chemistry and Biochemistry, Miami University, Oxford, OH 45056, USA.
Cohen SM; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, 92093, USA.
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Źródło :
ChemMedChem [ChemMedChem] 2020 Jul 20; Vol. 15 (14), pp. 1272-1282. Date of Electronic Publication: 2020 May 07.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Coordination Complexes/*pharmacology
Imino Acids/*pharmacology
Zinc/*pharmacology
beta-Lactamase Inhibitors/*pharmacology
beta-Lactamases/*metabolism
Coordination Complexes/chemical synthesis ; Coordination Complexes/chemistry ; Dose-Response Relationship, Drug ; Humans ; Imino Acids/chemical synthesis ; Imino Acids/chemistry ; Molecular Structure ; Structure-Activity Relationship ; Zinc/chemistry ; beta-Lactamase Inhibitors/chemical synthesis ; beta-Lactamase Inhibitors/chemistry
Czasopismo naukowe
Tytuł :
Bioisosteric investigation of ebselen: Synthesis and in vitro characterization of 1,2-benzisothiazol-3(2H)-one derivatives as potent New Delhi metallo-β-lactamase inhibitors.
Autorzy :
Jin WB; State Key Laboratory of Chemical Biology and Drug Discovery and Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong Special Administrative Region; Faculty of Chinese Materia Medica, Yunnan University of Chinese Medicine, Kunming, Yunnan, China.
Xu C; State Key Laboratory of Chemical Biology and Drug Discovery and Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong Special Administrative Region; Shenzhen Key Laboratory for Food Biological Safety Control, Food Safety and Technology Research Centre, The Hong Kong PolyU Shenzhen Research Institute, Shenzhen, China.
Cheung Q; State Key Laboratory of Chemical Biology and Drug Discovery and Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong Special Administrative Region; Shenzhen Key Laboratory for Food Biological Safety Control, Food Safety and Technology Research Centre, The Hong Kong PolyU Shenzhen Research Institute, Shenzhen, China.
Gao W; State Key Laboratory of Chemical Biology and Drug Discovery and Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong Special Administrative Region.
Zeng P; State Key Laboratory of Chemical Biology and Drug Discovery and Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong Special Administrative Region.
Liu J; State Key Laboratory of Chemical Biology and Drug Discovery and Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong Special Administrative Region.
Chan EWC; State Key Laboratory of Chemical Biology and Drug Discovery and Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong Special Administrative Region.
Leung YC; State Key Laboratory of Chemical Biology and Drug Discovery and Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong Special Administrative Region.
Chan TH; State Key Laboratory of Chemical Biology and Drug Discovery and Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong Special Administrative Region; Department of Chemistry, McGill University, Montreal, Quebec H3A 2K6, Canada.
Wong KY; State Key Laboratory of Chemical Biology and Drug Discovery and Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong Special Administrative Region.
Chen S; Department of Infectious Diseases and Public Health, Jockey Club College of Veterinary Medicine and Life Sciences, City University of Hong Kong, Kowloon, Hong Kong Special Administrative Region. Electronic address: .
Chan KF; State Key Laboratory of Chemical Biology and Drug Discovery and Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong Special Administrative Region. Electronic address: .
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Źródło :
Bioorganic chemistry [Bioorg Chem] 2020 Jul; Vol. 100, pp. 103873. Date of Electronic Publication: 2020 Apr 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Azoles/*chemistry
Azoles/*pharmacology
Escherichia coli/*drug effects
Escherichia coli Proteins/*antagonists & inhibitors
Organoselenium Compounds/*chemistry
Organoselenium Compounds/*pharmacology
beta-Lactamase Inhibitors/*chemistry
beta-Lactamase Inhibitors/*pharmacology
Anti-Bacterial Agents/chemical synthesis ; Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/pharmacology ; Azoles/chemical synthesis ; Escherichia coli/enzymology ; Escherichia coli Infections/drug therapy ; Escherichia coli Infections/microbiology ; Escherichia coli Proteins/metabolism ; Humans ; Molecular Docking Simulation ; Organoselenium Compounds/chemical synthesis ; Triazoles/chemical synthesis ; Triazoles/chemistry ; Triazoles/pharmacology ; beta-Lactamase Inhibitors/chemical synthesis ; beta-Lactamases/metabolism
Czasopismo naukowe
Tytuł :
Elucidating the Molecular Basis of Avibactam-Mediated Inhibition of Class A β-Lactamases.
Autorzy :
Das CK; Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur, 208016, India.; Current Address: Lehrstuhl für Theoretische Chemie, Ruhr Universität Bochum, 44780, Bochum, Germany.
Nair NN; Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur, 208016, India.
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Źródło :
Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2020 Aug 03; Vol. 26 (43), pp. 9639-9651. Date of Electronic Publication: 2020 Jul 09.
Typ publikacji :
Journal Article
MeSH Terms :
Anti-Bacterial Agents/*chemistry
Azabicyclo Compounds/*chemistry
Gram-Negative Bacteria/*drug effects
beta-Lactamase Inhibitors/*chemistry
beta-Lactamases/*chemistry
beta-Lactams/*chemistry
Acylation ; Anti-Bacterial Agents/pharmacology ; Catalytic Domain ; Gram-Negative Bacteria/chemistry ; Kinetics ; Molecular Dynamics Simulation ; beta-Lactamase Inhibitors/pharmacology ; beta-Lactamases/metabolism ; beta-Lactams/pharmacology
Czasopismo naukowe
Tytuł :
An integrated biophysical approach to discovering mechanisms of NDM-1 inhibition for several thiol-containing drugs.
Autorzy :
Fullington S; Department of Chemistry and Biochemistry, 160 Hughes Laboratories, Miami University, 651 E. High Street, Oxford, OH, 45056, USA.
Cheng Z; Department of Chemistry and Biochemistry, 160 Hughes Laboratories, Miami University, 651 E. High Street, Oxford, OH, 45056, USA.
Thomas C; Department of Chemistry and Biochemistry, 160 Hughes Laboratories, Miami University, 651 E. High Street, Oxford, OH, 45056, USA.
Miller C; Department of Chemistry and Biochemistry, 160 Hughes Laboratories, Miami University, 651 E. High Street, Oxford, OH, 45056, USA.
Yang K; Department of Chemistry and Biochemistry, 160 Hughes Laboratories, Miami University, 651 E. High Street, Oxford, OH, 45056, USA.
Ju LC; Department of Chemistry and Biochemistry, 160 Hughes Laboratories, Miami University, 651 E. High Street, Oxford, OH, 45056, USA.
Bergstrom A; Department of Chemistry and Biochemistry, 160 Hughes Laboratories, Miami University, 651 E. High Street, Oxford, OH, 45056, USA.
Shurina BA; Department of Chemistry and Biochemistry, 160 Hughes Laboratories, Miami University, 651 E. High Street, Oxford, OH, 45056, USA.
Bretz SL; Department of Chemistry and Biochemistry, 160 Hughes Laboratories, Miami University, 651 E. High Street, Oxford, OH, 45056, USA.
Page RC; Department of Chemistry and Biochemistry, 160 Hughes Laboratories, Miami University, 651 E. High Street, Oxford, OH, 45056, USA. .
Tierney DL; Department of Chemistry and Biochemistry, 160 Hughes Laboratories, Miami University, 651 E. High Street, Oxford, OH, 45056, USA. .
Crowder MW; Department of Chemistry and Biochemistry, 160 Hughes Laboratories, Miami University, 651 E. High Street, Oxford, OH, 45056, USA. .
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Źródło :
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry [J Biol Inorg Chem] 2020 Aug; Vol. 25 (5), pp. 717-727. Date of Electronic Publication: 2020 Jun 04.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Sulfhydryl Compounds/*pharmacology
beta-Lactamase Inhibitors/*pharmacology
beta-Lactamases/*metabolism
Humans ; Molecular Docking Simulation ; Molecular Structure ; Sulfhydryl Compounds/chemistry ; beta-Lactamase Inhibitors/chemistry ; beta-Lactamases/genetics
Czasopismo naukowe
Tytuł :
Structural insights of metallo-beta-lactamase revealed an effective way of inhibition of enzyme by natural inhibitors.
Autorzy :
Gangadharappa BS; Department of Biotechnology, M.S Ramaiah Institute of Technology, Bengaluru, Karnataka, India.; Visvesvaraya Technological University, Belagavi, Karnataka, India.
Sharath R; Department of Food Technology, Davangere University, Davangere, Karnataka, India.
Revanasiddappa PD; Department of Biotechnology, Siddaganga Institute of Technology, Tumakuru, Karnataka, India.
Chandramohan V; Department of Biotechnology, Siddaganga Institute of Technology, Tumakuru, Karnataka, India.
Balasubramaniam M; Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Vardhineni TP; Biotecthology Skill Enhancement Program, Siddaganga Institute of Technology, Tumakuru, Karnataka, India.
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Źródło :
Journal of biomolecular structure & dynamics [J Biomol Struct Dyn] 2020 Aug; Vol. 38 (13), pp. 3757-3771. Date of Electronic Publication: 2019 Sep 23.
Typ publikacji :
Journal Article
MeSH Terms :
beta-Lactamase Inhibitors*/pharmacology
beta-Lactamases*
Anti-Bacterial Agents/pharmacology ; Bacteria ; Enzyme Inhibitors ; Meropenem
Czasopismo naukowe
Tytuł :
4-( N -Alkyl- and -Acyl-amino)-1,2,4-triazole-3-thione Analogs as Metallo-β-Lactamase Inhibitors: Impact of 4-Linker on Potency and Spectrum of Inhibition.
Autorzy :
Gavara L; Institut des Biomolécules Max Mousseron, UMR5247 CNRS, Université de Montpellier, ENSCM, Faculté de Pharmacie, 34093 Montpellier, France.
Verdirosa F; Dipartimento di Biotecnologie Mediche, Università di Siena, I-53100 Siena, Italy.
Legru A; Institut des Biomolécules Max Mousseron, UMR5247 CNRS, Université de Montpellier, ENSCM, Faculté de Pharmacie, 34093 Montpellier, France.
Mercuri PS; Laboratoire des Macromolécules Biologiques, Centre d'Ingénierie des Protéines-InBioS, Université de Liège, Institute of Chemistry B6 a, Sart-Tilman, 4000 Liège, Belgium.
Nauton L; Institut de Chimie de Clermont-Ferrand, Université Clermont-Auvergne, CNRS, SIGMA Clermont, 63000 Clermont-Ferrand, France.
Sevaille L; Institut des Biomolécules Max Mousseron, UMR5247 CNRS, Université de Montpellier, ENSCM, Faculté de Pharmacie, 34093 Montpellier, France.
Feller G; Laboratoire de Biochimie, Centre d'Ingénierie des Protéines-InBioS, Université de Liège, B6, Sart-Tilman, 4000 Liège, Belgium.
Berthomieu D; Institut Charles Gerhardt, UMR5253, CNRS, Université de Montpellier, ENSCM, Cedex 5, 34296 Montpellier, France.
Sannio F; Dipartimento di Biotecnologie Mediche, Università di Siena, I-53100 Siena, Italy.
Marcoccia F; Dipartimento di Biotecnologie Mediche, Università di Siena, I-53100 Siena, Italy.
Tanfoni S; Dipartimento di Biotecnologie Mediche, Università di Siena, I-53100 Siena, Italy.
De Luca F; Dipartimento di Biotecnologie Mediche, Università di Siena, I-53100 Siena, Italy.
Gresh N; Laboratoire de Chimie Théorique, UMR7616, Sorbonne Université, CNRS, 75252 Paris, France.
Galleni M; Laboratoire des Macromolécules Biologiques, Centre d'Ingénierie des Protéines-InBioS, Université de Liège, Institute of Chemistry B6 a, Sart-Tilman, 4000 Liège, Belgium.
Docquier JD; Dipartimento di Biotecnologie Mediche, Università di Siena, I-53100 Siena, Italy.
Hernandez JF; Institut des Biomolécules Max Mousseron, UMR5247 CNRS, Université de Montpellier, ENSCM, Faculté de Pharmacie, 34093 Montpellier, France.
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Źródło :
Biomolecules [Biomolecules] 2020 Jul 23; Vol. 10 (8). Date of Electronic Publication: 2020 Jul 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Resistance, Bacterial/*drug effects
Gram-Negative Bacteria/*drug effects
Thiones/*chemistry
Triazoles/*chemistry
beta-Lactamase Inhibitors/*pharmacology
beta-Lactamases/*metabolism
Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/pharmacology ; Bacterial Infections/microbiology ; Bacterial Infections/prevention & control ; Biocatalysis/drug effects ; Carbapenems/chemistry ; Carbapenems/pharmacology ; Gram-Negative Bacteria/metabolism ; Humans ; Microbial Sensitivity Tests ; Molecular Structure ; beta-Lactamase Inhibitors/chemistry ; beta-Lactams/chemistry ; beta-Lactams/pharmacology
Czasopismo naukowe
Tytuł :
Molecular basis of the beta-lactamase protein using comparative modelling, drug screening and molecular dynamics studies to understand the resistance of β-lactam antibiotics.
Autorzy :
Alazmi M; Department of Computer Science, College of Computer Science and Engineering, University of Ha'il, P.O. Box 2440, Ha'il, 81481, Saudi Arabia. .
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Źródło :
Journal of molecular modeling [J Mol Model] 2020 Jul 07; Vol. 26 (8), pp. 200. Date of Electronic Publication: 2020 Jul 07.
Typ publikacji :
Journal Article
MeSH Terms :
Molecular Docking Simulation*
Molecular Dynamics Simulation*
Anti-Bacterial Agents/*chemistry
beta-Lactamase Inhibitors/*chemistry
beta-Lactamases/*chemistry
Anti-Bacterial Agents/pharmacology ; Base Sequence ; Binding Sites ; Chemical Phenomena ; Drug Discovery ; Drug Evaluation, Preclinical ; Humans ; Ligands ; Mutation ; Protein Binding ; Protein Conformation ; beta-Lactamase Inhibitors/pharmacology ; beta-Lactamases/genetics
Czasopismo naukowe

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