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Tytuł:
Combination of artesunate and WNT974 induces KRAS protein degradation by upregulating E3 ligase ANACP2 and β-TrCP in the ubiquitin-proteasome pathway.
Autorzy:
Gong RH; Centre for Cancer and Inflammation Research, School of Chinese Medicine, Hong Kong Baptist University, 7 Baptist University Road, Kowloon Tong, Hong Kong, China.
Chen M; Centre for Cancer and Inflammation Research, School of Chinese Medicine, Hong Kong Baptist University, 7 Baptist University Road, Kowloon Tong, Hong Kong, China.
Huang C; Centre for Cancer and Inflammation Research, School of Chinese Medicine, Hong Kong Baptist University, 7 Baptist University Road, Kowloon Tong, Hong Kong, China.
Wong HLX; Centre for Cancer and Inflammation Research, School of Chinese Medicine, Hong Kong Baptist University, 7 Baptist University Road, Kowloon Tong, Hong Kong, China.
Kwan HY; Centre for Cancer and Inflammation Research, School of Chinese Medicine, Hong Kong Baptist University, 7 Baptist University Road, Kowloon Tong, Hong Kong, China. .
Bian Z; Centre for Cancer and Inflammation Research, School of Chinese Medicine, Hong Kong Baptist University, 7 Baptist University Road, Kowloon Tong, Hong Kong, China. .
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Źródło:
Cell communication and signaling : CCS [Cell Commun Signal] 2022 Mar 19; Vol. 20 (1), pp. 34. Date of Electronic Publication: 2022 Mar 19.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Video-Audio Media
MeSH Terms:
Ubiquitin-Protein Ligases*/metabolism
beta-Transducin Repeat-Containing Proteins*/genetics
beta-Transducin Repeat-Containing Proteins*/metabolism
Animals ; Apc2 Subunit, Anaphase-Promoting Complex-Cyclosome/metabolism ; Artesunate/pharmacology ; Cell Line, Tumor ; Cullin Proteins ; Glycogen Synthase Kinase 3 beta/metabolism ; Humans ; Mice ; Phosphatidylinositol 3-Kinases/metabolism ; Proteasome Endopeptidase Complex/metabolism ; Proteolysis ; Proto-Oncogene Proteins c-akt/metabolism ; Proto-Oncogene Proteins p21(ras)/genetics ; Proto-Oncogene Proteins p21(ras)/metabolism ; Pyrazines ; Pyridines ; TOR Serine-Threonine Kinases/metabolism ; Ubiquitin-Conjugating Enzymes ; Ubiquitins/metabolism ; Wnt Signaling Pathway
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
miR-193a-3p Promotes the Invasion, Migration, and Mesenchymal Transition in Glioma through Regulating BTRC.
Autorzy:
Zhou DD; Department of Pathology, School of Clinical Medicine, Weifang Medical University, Weifang, Shandong 261053, China.
Li HL; Department of Pathology, School of Clinical Medicine, Weifang Medical University, Weifang, Shandong 261053, China.; Experimental Center for Medical Research, Weifang Medical University, Weifang, Shandong 261053, China.
Liu W; School of Clinical Medicine, Weifang Medical University, Weifang, Shandong 261053, China.
Zhang LP; Department of Pathology, School of Clinical Medicine, Weifang Medical University, Weifang, Shandong 261053, China.
Zheng Q; Department of Pathology, School of Clinical Medicine, Weifang Medical University, Weifang, Shandong 261053, China.
Bai J; Department of Pathology, School of Clinical Medicine, Weifang Medical University, Weifang, Shandong 261053, China.
Hu YQ; Department of Pathology, School of Clinical Medicine, Weifang Medical University, Weifang, Shandong 261053, China.
Yin CG; College of Nursing, Weifang Medical University, Weifang, Shandong 261053, China.
Lv SJ; Department of Pathology, School of Clinical Medicine, Weifang Medical University, Weifang, Shandong 261053, China.
Zhang BG; Department of Pathology, School of Clinical Medicine, Weifang Medical University, Weifang, Shandong 261053, China.
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Źródło:
BioMed research international [Biomed Res Int] 2021 Feb 09; Vol. 2021, pp. 8928509. Date of Electronic Publication: 2021 Feb 09 (Print Publication: 2021).
Typ publikacji:
Journal Article
MeSH Terms:
Brain Neoplasms*/genetics
Brain Neoplasms*/metabolism
Brain Neoplasms*/mortality
Brain Neoplasms*/pathology
Glioma*/genetics
Glioma*/metabolism
Glioma*/mortality
Glioma*/pathology
MicroRNAs*/genetics
MicroRNAs*/metabolism
beta-Transducin Repeat-Containing Proteins*/genetics
beta-Transducin Repeat-Containing Proteins*/metabolism
Epithelial-Mesenchymal Transition/*genetics
Brain/metabolism ; Cell Line, Tumor ; Cell Movement/genetics ; Humans ; Neoplasm Invasiveness/genetics ; Prognosis ; Protein Interaction Maps/genetics ; Transcriptome/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Human umbilical cord-derived mesenchymal stem cell transplantation supplemented with curcumin improves the outcomes of ischemic stroke via AKT/GSK-3β/β-TrCP/Nrf2 axis.
Autorzy:
Li Y; Department of Neurology, Southwest Hospital, Third Military Medical University (Army Medical University), 29 Gaotanyan Street, Chongqing, 400038, China.
Huang J; Department of Neurology, Southwest Hospital, Third Military Medical University (Army Medical University), 29 Gaotanyan Street, Chongqing, 400038, China.
Wang J; Department of Neurology, Southwest Hospital, Third Military Medical University (Army Medical University), 29 Gaotanyan Street, Chongqing, 400038, China.
Xia S; Department of Neurology, Southwest Hospital, Third Military Medical University (Army Medical University), 29 Gaotanyan Street, Chongqing, 400038, China.
Ran H; Department of Neurology, Southwest Hospital, Third Military Medical University (Army Medical University), 29 Gaotanyan Street, Chongqing, 400038, China.
Gao L; Department of Neurology, Southwest Hospital, Third Military Medical University (Army Medical University), 29 Gaotanyan Street, Chongqing, 400038, China.; Department of Traditional Chinese Medicine and Rheumatology, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, 400038, China.
Feng C; Department of Medical Engineering, 958th Hospital of the People's Liberation Army, Chongqing, 400038, China.
Gui L; Department of Neurology, Southwest Hospital, Third Military Medical University (Army Medical University), 29 Gaotanyan Street, Chongqing, 400038, China.
Zhou Z; Department of Neurology, Southwest Hospital, Third Military Medical University (Army Medical University), 29 Gaotanyan Street, Chongqing, 400038, China. .
Yuan J; Department of Neurology, Southwest Hospital, Third Military Medical University (Army Medical University), 29 Gaotanyan Street, Chongqing, 400038, China. yuanjichao_.
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Źródło:
Journal of neuroinflammation [J Neuroinflammation] 2023 Feb 24; Vol. 20 (1), pp. 49. Date of Electronic Publication: 2023 Feb 24.
Typ publikacji:
Journal Article
MeSH Terms:
Ischemic Stroke*
Mesenchymal Stem Cell Transplantation*
Curcumin*
Humans ; Mice ; Animals ; Glycogen Synthase Kinase 3 beta ; Proto-Oncogene Proteins c-akt ; beta-Transducin Repeat-Containing Proteins ; NF-E2-Related Factor 2 ; Antioxidants ; Infarction, Middle Cerebral Artery ; Cytokines ; Umbilical Cord ; Anti-Inflammatory Agents/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Inter-Fighting between Influenza A Virus NS1 and β-TrCP: A Novel Mechanism of Anti-Influenza Virus.
Autorzy:
Sun H; Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai 200241, China.; Biosafety Research Center, Chinese Academy of Agricultural Sciences, Shanghai 200241, China.
Wang K; Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai 200241, China.
Yao W; Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai 200241, China.
Liu J; Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai 200241, China.; Biosafety Research Center, Chinese Academy of Agricultural Sciences, Shanghai 200241, China.
Lv L; Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai 200241, China.; Biosafety Research Center, Chinese Academy of Agricultural Sciences, Shanghai 200241, China.
Shi X; Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai 200241, China.; Biosafety Research Center, Chinese Academy of Agricultural Sciences, Shanghai 200241, China.
Chen H; Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai 200241, China.; Biosafety Research Center, Chinese Academy of Agricultural Sciences, Shanghai 200241, China.
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Źródło:
Viruses [Viruses] 2022 Oct 31; Vol. 14 (11). Date of Electronic Publication: 2022 Oct 31.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Influenza A virus*/metabolism
Influenza, Human*
Humans ; beta-Transducin Repeat-Containing Proteins/genetics ; beta-Transducin Repeat-Containing Proteins/metabolism ; NF-kappa B/metabolism ; Viral Nonstructural Proteins/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Circular RNA circPVT1 promotes nasopharyngeal carcinoma metastasis via the β-TrCP/c-Myc/SRSF1 positive feedback loop.
Autorzy:
Mo Y; NHC Key Laboratory of Carcinogenesis and Hunan Key Laboratory of Cancer Metabolism, Hunan Cancer Hospital and Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China.; Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, 410078, Hunan, China.
Wang Y; Department of Otolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, 410078, Hunan, China.; National Clinical Research Center for Geriatric Disorders (Xiangya Hospital), 87 Xiangya Road, Changsha, 410008, Hunan, China.
Wang Y; NHC Key Laboratory of Carcinogenesis and Hunan Key Laboratory of Cancer Metabolism, Hunan Cancer Hospital and Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China.; Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, 410078, Hunan, China.
Deng X; NHC Key Laboratory of Carcinogenesis and Hunan Key Laboratory of Cancer Metabolism, Hunan Cancer Hospital and Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China.; Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, 410078, Hunan, China.
Yan Q; Department of Pathology, Xiangya Hospital, Central South University, Changsha, 410078, Hunan, China.
Fan C; NHC Key Laboratory of Carcinogenesis and Hunan Key Laboratory of Cancer Metabolism, Hunan Cancer Hospital and Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China.; Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, 410078, Hunan, China.
Zhang S; Department of Otolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, 410078, Hunan, China.
Zhang S; Department of Stomatology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Gong Z; Department of Oral and Maxillofacial Surgery, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China.
Shi L; Department of Oral and Maxillofacial Surgery, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China.
Liao Q; NHC Key Laboratory of Carcinogenesis and Hunan Key Laboratory of Cancer Metabolism, Hunan Cancer Hospital and Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China.
Guo C; NHC Key Laboratory of Carcinogenesis and Hunan Key Laboratory of Cancer Metabolism, Hunan Cancer Hospital and Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China.; Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, 410078, Hunan, China.
Li Y; Department of Medicine, Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX, USA.
Li G; NHC Key Laboratory of Carcinogenesis and Hunan Key Laboratory of Cancer Metabolism, Hunan Cancer Hospital and Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China.; Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, 410078, Hunan, China.
Zeng Z; NHC Key Laboratory of Carcinogenesis and Hunan Key Laboratory of Cancer Metabolism, Hunan Cancer Hospital and Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China.; Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, 410078, Hunan, China.
Jiang W; Department of Otolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, 410078, Hunan, China.; National Clinical Research Center for Geriatric Disorders (Xiangya Hospital), 87 Xiangya Road, Changsha, 410008, Hunan, China.
Xiong W; NHC Key Laboratory of Carcinogenesis and Hunan Key Laboratory of Cancer Metabolism, Hunan Cancer Hospital and Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China.; Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, 410078, Hunan, China.
Xiang B; NHC Key Laboratory of Carcinogenesis and Hunan Key Laboratory of Cancer Metabolism, Hunan Cancer Hospital and Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China. .; Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, 410078, Hunan, China. .
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Źródło:
Molecular cancer [Mol Cancer] 2022 Oct 05; Vol. 21 (1), pp. 192. Date of Electronic Publication: 2022 Oct 05.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Carcinoma*/genetics
MicroRNAs*/genetics
Nasopharyngeal Neoplasms*/genetics
Nasopharyngeal Neoplasms*/metabolism
Nasopharyngeal Neoplasms*/pathology
Biomarkers ; Cell Line, Tumor ; Cell Movement ; Cell Proliferation ; Feedback ; Gene Expression Regulation, Neoplastic ; Humans ; Ligases/genetics ; Nasopharyngeal Carcinoma/pathology ; RNA ; RNA Splicing Factors/genetics ; RNA, Circular/genetics ; Serine-Arginine Splicing Factors ; beta-Transducin Repeat-Containing Proteins/genetics ; beta-Transducin Repeat-Containing Proteins/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Structural basis of βTrCP1-associated GLI3 processing.
Autorzy:
Shafique S; National Center for Bioinformatics, Quaid I Azam University, Islamabad, Pakistan.
Rashid S; National Center for Bioinformatics, Quaid I Azam University, Islamabad, Pakistan. .
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Źródło:
Scientific reports [Sci Rep] 2019 May 03; Vol. 9 (1), pp. 6865. Date of Electronic Publication: 2019 May 03.
Typ publikacji:
Journal Article
MeSH Terms:
Nerve Tissue Proteins/*chemistry
Nerve Tissue Proteins/*metabolism
Zinc Finger Protein Gli3/*chemistry
Zinc Finger Protein Gli3/*metabolism
beta-Transducin Repeat-Containing Proteins/*metabolism
Humans ; Molecular Dynamics Simulation ; Protein Conformation, beta-Strand ; Thermodynamics ; beta-Transducin Repeat-Containing Proteins/chemistry
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
βTrCP is Required for HIV-1 Vpu Modulation of CD4, GaLV Env, and BST-2/Tetherin.
Autorzy:
Song YE; Department of Molecular Microbiology and Immunology, University of Missouri, School of Medicine and the Christopher S. Bond Life Sciences Center, Columbia, MO 65211, USA. .
Cyburt D; Department of Molecular Microbiology and Immunology, University of Missouri, School of Medicine and the Christopher S. Bond Life Sciences Center, Columbia, MO 65211, USA. .
Lucas TM; Gene Therapies Branch, Center for Biologics Evaluation and Research, FDA, 10903 New Hampshire Ave, Silver Spring, MD 20903, USA. .
Gregory DA; Department of Molecular Microbiology and Immunology, University of Missouri, School of Medicine and the Christopher S. Bond Life Sciences Center, Columbia, MO 65211, USA. .
Lyddon TD; Department of Molecular Microbiology and Immunology, University of Missouri, School of Medicine and the Christopher S. Bond Life Sciences Center, Columbia, MO 65211, USA. .
Johnson MC; Department of Molecular Microbiology and Immunology, University of Missouri, School of Medicine and the Christopher S. Bond Life Sciences Center, Columbia, MO 65211, USA. .
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Źródło:
Viruses [Viruses] 2018 Oct 19; Vol. 10 (10). Date of Electronic Publication: 2018 Oct 19.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Antigens, CD/*metabolism
CD4 Antigens/*metabolism
HIV Infections/*metabolism
HIV-1/*metabolism
Human Immunodeficiency Virus Proteins/*metabolism
Viral Envelope Proteins/*metabolism
Viral Regulatory and Accessory Proteins/*metabolism
beta-Transducin Repeat-Containing Proteins/*metabolism
Antigens, CD/genetics ; CD4 Antigens/genetics ; Cell Line ; GPI-Linked Proteins/genetics ; GPI-Linked Proteins/metabolism ; HIV Infections/genetics ; HIV Infections/virology ; HIV-1/genetics ; Host-Pathogen Interactions ; Human Immunodeficiency Virus Proteins/genetics ; Humans ; Leukemia Virus, Gibbon Ape/genetics ; Leukemia Virus, Gibbon Ape/metabolism ; Protein Binding ; Viral Envelope Proteins/genetics ; Viral Regulatory and Accessory Proteins/genetics ; beta-Transducin Repeat-Containing Proteins/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Association of FBXW11 levels with tumor development and prognosis in chondrosarcoma.
Autorzy:
Chen C; Department of Spinal Surgery, Tianjin Hospital, Tianjin, China.
Zhou H; Department of Orthopaedic Surgery, Peking University Third Hospital, Beijing, China.
Zhang X; Department of Spinal Surgery, Tianjin Hospital, Tianjin, China.
Liu Z; Department of Orthopaedic Surgery, Peking University Third Hospital, Beijing, China.
Ma X; Department of Spinal Surgery, Tianjin Hospital, Tianjin, China.
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Źródło:
Cancer biomarkers : section A of Disease markers [Cancer Biomark] 2022; Vol. 35 (4), pp. 429-437.
Typ publikacji:
Journal Article
MeSH Terms:
Bone Neoplasms*/metabolism
Chondrosarcoma*/genetics
Chondrosarcoma*/metabolism
Humans ; Prognosis ; Apoptosis/genetics ; Ubiquitin-Protein Ligases/genetics ; Ubiquitin-Protein Ligases/metabolism ; Cell Proliferation/genetics ; Cell Line, Tumor ; beta-Transducin Repeat-Containing Proteins
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
FBXW8 regulates G1 and S phases of cell cycle progression by restricting β-TrCP1 function.
Autorzy:
Islam S; Molecular Oncology Laboratory, National Centre for Cell Science, Pune, India.; Department of Biotechnology, Savitribai Phule Pune University, India.
Dutta P; Molecular Oncology Laboratory, National Centre for Cell Science, Pune, India.; Department of Biotechnology, Savitribai Phule Pune University, India.
Chopra K; Laboratory of Structural Biology, National Centre for Cell Science, Pune, India.
Rapole S; Proteomics Laboratory, National Centre for Cell Science, Pune, India.
Chauhan R; Laboratory of Structural Biology, National Centre for Cell Science, Pune, India.
Santra MK; Molecular Oncology Laboratory, National Centre for Cell Science, Pune, India.
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Źródło:
The FEBS journal [FEBS J] 2021 Sep; Vol. 288 (18), pp. 5474-5497. Date of Electronic Publication: 2021 Apr 05.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cell Cycle Proteins/*genetics
F-Box Proteins/*genetics
beta-Transducin Repeat-Containing Proteins/*genetics
cdc25 Phosphatases/*genetics
Cell Division/genetics ; DNA Damage/genetics ; Flow Cytometry ; G1 Phase/genetics ; Gene Expression Regulation, Developmental/genetics ; HEK293 Cells ; Humans ; MCF-7 Cells ; Proteasome Endopeptidase Complex/genetics ; Proteolysis ; S Phase/genetics ; Ubiquitin/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
The characteristics and roles of β-TrCP1/2 in carcinogenesis.
Autorzy:
Bi Y; Key Laboratory of Combined Multi-Organ Transplantation, Ministry of Public Health, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.; Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, China.
Cui D; Key Laboratory of Combined Multi-Organ Transplantation, Ministry of Public Health, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.; Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, China.
Xiong X; Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, China.; Cancer Institute of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Zhao Y; Key Laboratory of Combined Multi-Organ Transplantation, Ministry of Public Health, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.; Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, China.
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Źródło:
The FEBS journal [FEBS J] 2021 Jun; Vol. 288 (11), pp. 3351-3374. Date of Electronic Publication: 2020 Oct 23.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
Carcinogenesis/*genetics
Neoplasms/*genetics
Ubiquitin-Protein Ligases/*genetics
beta-Transducin Repeat-Containing Proteins/*genetics
Carrier Proteins/genetics ; Cullin Proteins/genetics ; DNA Damage/genetics ; Humans ; Neoplasms/pathology ; S-Phase Kinase-Associated Proteins/genetics ; SKP Cullin F-Box Protein Ligases/genetics ; Signal Transduction/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
SAG/RBX2 E3 ligase complexes with UBCH10 and UBE2S E2s to ubiquitylate β-TrCP1 via K11-linkage for degradation.
Autorzy:
Kuang P; Department of Internal Medicine, Beijing University School of Medicine, 38 Xueyuan Road, Beijing, 100191, China.; Division of Radiation and Cancer Biology, Department of Radiation Oncology, University of Michigan, 4424B MS-1, 1301 Catherine Street, Ann Arbor, MI 48109, USA.
Tan M; Division of Radiation and Cancer Biology, Department of Radiation Oncology, University of Michigan, 4424B MS-1, 1301 Catherine Street, Ann Arbor, MI 48109, USA.
Zhou W; Division of Radiation and Cancer Biology, Department of Radiation Oncology, University of Michigan, 4424B MS-1, 1301 Catherine Street, Ann Arbor, MI 48109, USA.
Zhang Q; Division of Radiation and Cancer Biology, Department of Radiation Oncology, University of Michigan, 4424B MS-1, 1301 Catherine Street, Ann Arbor, MI 48109, USA.
Sun Y; Division of Radiation and Cancer Biology, Department of Radiation Oncology, University of Michigan, 4424B MS-1, 1301 Catherine Street, Ann Arbor, MI 48109, USA.; Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, Zhejiang, People's Republic of China.; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang University, Hangzhou, P. R. China.
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Źródło:
Scientific reports [Sci Rep] 2016 Dec 02; Vol. 6, pp. 37441. Date of Electronic Publication: 2016 Dec 02.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Epithelial Cells/*metabolism
Lysine/*metabolism
Ubiquitin-Conjugating Enzymes/*genetics
Ubiquitin-Protein Ligases/*genetics
beta-Transducin Repeat-Containing Proteins/*genetics
Animals ; Carrier Proteins/genetics ; Carrier Proteins/metabolism ; Cell Line, Tumor ; Cullin Proteins/genetics ; Cullin Proteins/metabolism ; Epithelial Cells/cytology ; Gene Expression Regulation ; HEK293 Cells ; Half-Life ; Humans ; Mice ; Mouse Embryonic Stem Cells/cytology ; Mouse Embryonic Stem Cells/metabolism ; Protein Binding ; Protein Isoforms/genetics ; Protein Isoforms/metabolism ; Proteolysis ; RNA, Small Interfering/genetics ; RNA, Small Interfering/metabolism ; Signal Transduction ; Ubiquitin-Conjugating Enzymes/antagonists & inhibitors ; Ubiquitin-Conjugating Enzymes/metabolism ; Ubiquitin-Protein Ligases/metabolism ; Ubiquitination ; beta-Transducin Repeat-Containing Proteins/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
A 2-Benzylmalonate Derivative as STAT3 Inhibitor Suppresses Tumor Growth in Hepatocellular Carcinoma by Upregulating β-TrCP E3 Ubiquitin Ligase.
Autorzy:
Peng T; Center for Natural Products Research, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China.; University of Chinese Academy of Sciences, Beijing 100049, China.
Wonganan O; Center for Natural Products Research, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China.
Zhang Z; School of Chemistry Engineering, Sichuan University, Chengdu 610041, China.
Yu J; Center for Natural Products Research, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China.; University of Chinese Academy of Sciences, Beijing 100049, China.
Xi R; Center for Natural Products Research, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China.; University of Chinese Academy of Sciences, Beijing 100049, China.
Cao Y; Center for Natural Products Research, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China.; University of Chinese Academy of Sciences, Beijing 100049, China.
Suksamrarn A; Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Ramkhamhaeng University, Bangkok 10240, Thailand.
Zhang G; Center for Natural Products Research, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China.
Wang F; Center for Natural Products Research, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China.; Xiongan Institute of Innovation, Chinese Academy of Sciences, Hebei 071700, China.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Mar 25; Vol. 22 (7). Date of Electronic Publication: 2021 Mar 25.
Typ publikacji:
Journal Article
MeSH Terms:
Carcinoma, Hepatocellular/*metabolism
Liver Neoplasms/*metabolism
Malonates/*pharmacology
STAT3 Transcription Factor/*metabolism
Ubiquitin-Protein Ligases/*metabolism
beta-Transducin Repeat-Containing Proteins/*metabolism
Animals ; Cell Line, Tumor ; Cell Movement/drug effects ; Cell Survival/drug effects ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; Hep G2 Cells ; Humans ; Inhibitory Concentration 50 ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Neoplasm Invasiveness ; Neoplasm Transplantation ; Phosphorylation ; Recombinant Proteins/chemistry ; Response Elements ; Transducin ; Up-Regulation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
β-TrCP-mediated ubiquitination and degradation of liver-enriched transcription factor CREB-H.
Autorzy:
Cheng Y; School of Biomedical Sciences, The University of Hong Kong, Pokfulam, Hong Kong.; State Key Laboratory for Liver Research, The University of Hong Kong, Pokfulam, Hong Kong.
Gao WW; School of Biomedical Sciences, The University of Hong Kong, Pokfulam, Hong Kong.; State Key Laboratory for Liver Research, The University of Hong Kong, Pokfulam, Hong Kong.
Tang HM; School of Biomedical Sciences, The University of Hong Kong, Pokfulam, Hong Kong.; State Key Laboratory for Liver Research, The University of Hong Kong, Pokfulam, Hong Kong.; Shenzhen Institute of Research and Innovation, The University of Hong Kong, Shenzhen, China.
Deng JJ; School of Biomedical Sciences, The University of Hong Kong, Pokfulam, Hong Kong.; State Key Laboratory for Liver Research, The University of Hong Kong, Pokfulam, Hong Kong.; Department of Food Science and Engineering, College of Chemical Engineering, Northwestern University, Xi'an 710069, China.
Wong CM; Shenzhen Institute of Research and Innovation, The University of Hong Kong, Shenzhen, China.; Department of Medicine and State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Pokfulam, Hong Kong.
Chan CP; School of Biomedical Sciences, The University of Hong Kong, Pokfulam, Hong Kong.; State Key Laboratory for Liver Research, The University of Hong Kong, Pokfulam, Hong Kong.; Shenzhen Institute of Research and Innovation, The University of Hong Kong, Shenzhen, China.
Jin DY; School of Biomedical Sciences, The University of Hong Kong, Pokfulam, Hong Kong.; State Key Laboratory for Liver Research, The University of Hong Kong, Pokfulam, Hong Kong.; Shenzhen Institute of Research and Innovation, The University of Hong Kong, Shenzhen, China.
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Źródło:
Scientific reports [Sci Rep] 2016 Mar 31; Vol. 6, pp. 23938. Date of Electronic Publication: 2016 Mar 31.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Signal Transduction*
Transcription, Genetic*
Cyclic AMP Response Element-Binding Protein/*genetics
Liver/*metabolism
beta-Transducin Repeat-Containing Proteins/*genetics
Amino Acid Sequence ; Binding Sites ; Cyclic AMP Response Element-Binding Protein/metabolism ; Gene Expression Regulation ; HEK293 Cells ; Hep G2 Cells ; Humans ; Phosphorylation ; Proteasome Endopeptidase Complex/metabolism ; Protein Binding ; Protein Transport ; Proteolysis ; RNA, Small Interfering/genetics ; RNA, Small Interfering/metabolism ; Sequence Alignment ; Sequence Homology, Amino Acid ; Ubiquitination ; beta-Transducin Repeat-Containing Proteins/antagonists & inhibitors ; beta-Transducin Repeat-Containing Proteins/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
The role of SCF in the cerebellar granule cell precursors.
Autorzy:
Yamashita M; Department of Biochemistry and Cellular Biology, National Institute of Neuroscience, NCNP, Tokyo, Japan.
Owa T; Department of Biochemistry and Cellular Biology, National Institute of Neuroscience, NCNP, Tokyo, Japan.
Shiraishi R; Department of Biochemistry and Cellular Biology, National Institute of Neuroscience, NCNP, Tokyo, Japan.; Department of NCNP Brain Function and Pathology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, TMDU, Tokyo, Japan.
Adachi T; Department of Biochemistry and Cellular Biology, National Institute of Neuroscience, NCNP, Tokyo, Japan.; Department of Life Science and Medical Bioscience, Graduate School of Advance Science and Engineering, TWIns, Waseda University, Tokyo, Japan.
Ichijo K; Department of Biochemistry and Cellular Biology, National Institute of Neuroscience, NCNP, Tokyo, Japan.; Department of Otolaryngology and Head and Neck Surgery, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.
Taya S; Department of Biochemistry and Cellular Biology, National Institute of Neuroscience, NCNP, Tokyo, Japan.
Miyashita S; Department of Biochemistry and Cellular Biology, National Institute of Neuroscience, NCNP, Tokyo, Japan.
Hoshino M; Department of Biochemistry and Cellular Biology, National Institute of Neuroscience, NCNP, Tokyo, Japan.
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Źródło:
Genes to cells : devoted to molecular & cellular mechanisms [Genes Cells] 2020 Dec; Vol. 25 (12), pp. 796-810. Date of Electronic Publication: 2020 Nov 23.
Typ publikacji:
Journal Article
MeSH Terms:
Neurogenesis*
Cerebellum/*cytology
Neural Stem Cells/*metabolism
S-Phase Kinase-Associated Proteins/*metabolism
beta-Transducin Repeat-Containing Proteins/*metabolism
Animals ; Cell Line, Tumor ; Cell Proliferation ; Cells, Cultured ; Cerebellum/metabolism ; Cullin Proteins/metabolism ; Cyclin-Dependent Kinase Inhibitor p27/metabolism ; HEK293 Cells ; Humans ; Mice ; Mice, Inbred ICR ; Neural Stem Cells/cytology ; S-Phase Kinase-Associated Proteins/genetics ; Ubiquitination
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
PLK1 and β-TrCP-dependent ubiquitination and degradation of Rap1GAP controls cell proliferation.
Autorzy:
Wang D; State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, P.R. China; Department of Gastroenterology, Jiangxi Institute of Gastroenterology & Hepatology, the First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, P. R. China.
Zhang P; State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, P.R. China; Institutes of Biomedical Sciences, Fudan University, Shanghai, P.R. China.
Gao K; State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, P.R. China.
Tang Y; State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, P.R. China.
Jin X; State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, P.R. China.
Zhang Y; State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, P.R. China.
Yi Q; Department of Lymphoma and Myeloma, Division of Cancer Medicine, Center for Cancer Immunology Research, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America.
Wang C; State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, P.R. China.
Yu L; State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, P.R. China; Institutes of Biomedical Sciences, Fudan University, Shanghai, P.R. China.
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Źródło:
PloS one [PLoS One] 2014 Oct 17; Vol. 9 (10), pp. e110296. Date of Electronic Publication: 2014 Oct 17 (Print Publication: 2014).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cell Proliferation*
Proteolysis*
Ubiquitination*
Cell Cycle Proteins/*metabolism
GTPase-Activating Proteins/*metabolism
Protein Serine-Threonine Kinases/*metabolism
Proto-Oncogene Proteins/*metabolism
beta-Transducin Repeat-Containing Proteins/*metabolism
Binding Sites ; Cell Cycle Proteins/genetics ; GTPase-Activating Proteins/chemistry ; GTPase-Activating Proteins/genetics ; HEK293 Cells ; HeLa Cells ; Humans ; Mitosis ; Protein Binding ; Protein Serine-Threonine Kinases/genetics ; Proto-Oncogene Proteins/genetics ; beta-Transducin Repeat-Containing Proteins/genetics ; Polo-Like Kinase 1
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
BimEL is phosphorylated at mitosis by Aurora A and targeted for degradation by βTrCP1.
Autorzy:
Moustafa-Kamal M; Goodman Cancer Research Center, McGill University, Montréal, Québec, Canada.
Gamache I
Lu Y
Li S
Teodoro JG
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Źródło:
Cell death and differentiation [Cell Death Differ] 2013 Oct; Vol. 20 (10), pp. 1393-403. Date of Electronic Publication: 2013 Aug 02.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Apoptosis Regulatory Proteins/*metabolism
Aurora Kinase A/*metabolism
Membrane Proteins/*metabolism
Proto-Oncogene Proteins/*metabolism
beta-Transducin Repeat-Containing Proteins/*metabolism
Apoptosis/physiology ; Apoptosis Regulatory Proteins/genetics ; Bcl-2-Like Protein 11 ; HEK293 Cells ; HeLa Cells ; Humans ; M Phase Cell Cycle Checkpoints/physiology ; Membrane Proteins/genetics ; Mitosis/physiology ; Phosphorylation ; Proto-Oncogene Proteins/genetics ; Transfection ; Ubiquitination ; beta-Transducin Repeat-Containing Proteins/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity.
Autorzy:
Chowdhry S; Jacqui Wood Cancer Centre, Division of Cancer Research, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, UK.
Zhang Y
McMahon M
Sutherland C
Cuadrado A
Hayes JD
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Źródło:
Oncogene [Oncogene] 2013 Aug 08; Vol. 32 (32), pp. 3765-81. Date of Electronic Publication: 2012 Sep 10.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Glycogen Synthase Kinase 3/*metabolism
NF-E2-Related Factor 2/*physiology
beta-Transducin Repeat-Containing Proteins/*metabolism
Animals ; Antineoplastic Agents/pharmacology ; Binding Sites ; Extracellular Signal-Regulated MAP Kinases/physiology ; Humans ; Intracellular Signaling Peptides and Proteins/physiology ; Kelch-Like ECH-Associated Protein 1 ; Mice ; NF-E2-Related Factor 2/analysis ; NF-E2-Related Factor 2/chemistry ; Phosphatidylinositol 3-Kinases/physiology ; Phosphorylation ; Protein Structure, Tertiary ; Ubiquitination ; beta-Transducin Repeat-Containing Proteins/chemistry ; p38 Mitogen-Activated Protein Kinases/physiology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Poxvirus targeting of E3 ligase β-TrCP by molecular mimicry: a mechanism to inhibit NF-κB activation and promote immune evasion and virulence.
Autorzy:
Mansur DS; Department of Virology, Faculty of Medicine, Imperial College London, St Mary's Campus, London, United Kingdom.
Maluquer de Motes C
Unterholzner L
Sumner RP
Ferguson BJ
Ren H
Strnadova P
Bowie AG
Smith GL
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Źródło:
PLoS pathogens [PLoS Pathog] 2013 Feb; Vol. 9 (2), pp. e1003183. Date of Electronic Publication: 2013 Feb 28.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Molecular Mimicry*
NF-kappa B/*antagonists & inhibitors
Ubiquitin-Protein Ligases/*metabolism
Vaccinia virus/*pathogenicity
Variola virus/*pathogenicity
beta-Transducin Repeat-Containing Proteins/*metabolism
Animals ; Cell Line ; I-kappa B Kinase/genetics ; I-kappa B Kinase/metabolism ; Immune Evasion ; Mice ; Mice, Inbred BALB C ; Mutagenesis, Site-Directed ; NF-kappa B/genetics ; NF-kappa B/metabolism ; Phosphorylation ; Protein Binding ; Ubiquitin-Protein Ligases/genetics ; Vaccinia virus/genetics ; Vaccinia virus/immunology ; Variola virus/genetics ; Variola virus/immunology ; Virulence ; beta-Transducin Repeat-Containing Proteins/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
β-TrCP is dispensable for Vpu's ability to overcome the CD317/Tetherin-imposed restriction to HIV-1 release.
Autorzy:
Tervo HM; Department of Infectious Diseases, Virology, University of Heidelberg, Heidelberg, Germany.
Homann S
Ambiel I
Fritz JV
Fackler OT
Keppler OT
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Źródło:
Retrovirology [Retrovirology] 2011 Feb 10; Vol. 8, pp. 9. Date of Electronic Publication: 2011 Feb 10.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antigens, CD/*metabolism
HIV-1/*physiology
Human Immunodeficiency Virus Proteins/*metabolism
Viral Regulatory and Accessory Proteins/*metabolism
beta-Transducin Repeat-Containing Proteins/*metabolism
Antigens, CD/genetics ; Cell Line ; Cell Membrane/metabolism ; Cell Membrane/virology ; Down-Regulation ; GPI-Linked Proteins/genetics ; GPI-Linked Proteins/metabolism ; HIV-1/genetics ; HIV-1/metabolism ; HeLa Cells ; Human Immunodeficiency Virus Proteins/genetics ; Humans ; Viral Regulatory and Accessory Proteins/genetics ; Virion/metabolism ; Virion/physiology ; Virus Release/physiology ; beta-Transducin Repeat-Containing Proteins/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Wyświetlanie 1-20 z 94

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