Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

Przeglądasz jako GOŚĆ

Wyszukujesz frazę ""blood-brain barrier"" wg kryterium: Temat


Tytuł :
P7C3-A20 treatment one year after TBI in mice repairs the blood-brain barrier, arrests chronic neurodegeneration, and restores cognition.
Autorzy :
Vázquez-Rosa E; Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland, OH 44106.; Department of Psychiatry, Case Western Reserve University, Cleveland, OH 44106.; Geriatric Research Education and Clinical Centers, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, OH 44106.
Shin MK; Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland, OH 44106.; Department of Psychiatry, Case Western Reserve University, Cleveland, OH 44106.; Geriatric Research Education and Clinical Centers, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, OH 44106.
Dhar M; Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland, OH 44106.; Department of Psychiatry, Case Western Reserve University, Cleveland, OH 44106.; Geriatric Research Education and Clinical Centers, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, OH 44106.
Chaubey K; Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland, OH 44106.; Department of Psychiatry, Case Western Reserve University, Cleveland, OH 44106.; Geriatric Research Education and Clinical Centers, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, OH 44106.
Cintrón-Pérez CJ; Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland, OH 44106.; Department of Psychiatry, Case Western Reserve University, Cleveland, OH 44106.; Geriatric Research Education and Clinical Centers, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, OH 44106.
Tang X; Case Cardiovascular Research Institute, Department of Medicine, Case Western Reserve University, Cleveland, OH 44106.; Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, Cleveland, OH 44106.
Liao X; Case Cardiovascular Research Institute, Department of Medicine, Case Western Reserve University, Cleveland, OH 44106.; Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, Cleveland, OH 44106.
Miller E; Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland, OH 44106.; Department of Psychiatry, Case Western Reserve University, Cleveland, OH 44106.; Geriatric Research Education and Clinical Centers, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, OH 44106.
Koh Y; Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland, OH 44106.; Department of Psychiatry, Case Western Reserve University, Cleveland, OH 44106.; Geriatric Research Education and Clinical Centers, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, OH 44106.
Barker S; Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland, OH 44106.; Department of Psychiatry, Case Western Reserve University, Cleveland, OH 44106.; Geriatric Research Education and Clinical Centers, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, OH 44106.
Franke K; Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland, OH 44106.; Department of Psychiatry, Case Western Reserve University, Cleveland, OH 44106.; Geriatric Research Education and Clinical Centers, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, OH 44106.
Crosby DR; Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland, OH 44106.; Department of Psychiatry, Case Western Reserve University, Cleveland, OH 44106.; Geriatric Research Education and Clinical Centers, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, OH 44106.
Schroeder R; The Department of Psychiatry, University of Iowa, Iowa City, IA 52242.
Emery J; The Department of Psychiatry, University of Iowa, Iowa City, IA 52242.
Yin TC; The Department of Psychiatry, University of Iowa, Iowa City, IA 52242.
Fujioka H; Cryo-Electron Microscopy Core, Case Western Reserve University School of Medicine, Cleveland, OH 44106.
Reynolds JD; Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland, OH 44106.; Institute for Transformative Molecular Medicine, School of Medicine, Case Western Reserve University, Cleveland, OH 44106.; Department of Anesthesiology and Perioperative Medicine, University Hospitals Cleveland Medical Center, Cleveland, OH 44106.
Harper MM; Center for the Prevention and Treatment of Visual Loss, Veterans Affairs Medical Center, Iowa City, IA 52246.; Department of Ophthalmology and Visual Sciences, The University of Iowa, Iowa City, IA 52242.
Jain MK; Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland, OH 44106.; Case Cardiovascular Research Institute, Department of Medicine, Case Western Reserve University, Cleveland, OH 44106.; Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, Cleveland, OH 44106.
Pieper AA; Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland, OH 44106; .; Department of Psychiatry, Case Western Reserve University, Cleveland, OH 44106.; Geriatric Research Education and Clinical Centers, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, OH 44106.; Institute for Transformative Molecular Medicine, School of Medicine, Case Western Reserve University, Cleveland, OH 44106.; Weill Cornell Autism Research Program, Weill Cornell Medicine of Cornell University, New York, NY 10065.; Department of Neuroscience, School of Medicine, Case Western Reserve University, Cleveland, OH 44106.
Pokaż więcej
Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Nov 03; Vol. 117 (44), pp. 27667-27675. Date of Electronic Publication: 2020 Oct 21.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Blood-Brain Barrier/*drug effects
Brain Injuries, Traumatic/*drug therapy
Carbazoles/*pharmacology
Cognition/*drug effects
Neurodegenerative Diseases/*drug therapy
Neuroprotective Agents/*pharmacology
Animals ; Behavior, Animal/drug effects ; Behavior, Animal/physiology ; Blood-Brain Barrier/cytology ; Blood-Brain Barrier/pathology ; Blood-Brain Barrier/ultrastructure ; Brain Injuries, Traumatic/complications ; Brain Injuries, Traumatic/pathology ; Carbazoles/therapeutic use ; Cells, Cultured ; Chronic Disease/drug therapy ; Cognition/physiology ; Disease Models, Animal ; Endothelial Cells ; Endothelium, Vascular/cytology ; Endothelium, Vascular/drug effects ; Endothelium, Vascular/pathology ; Humans ; Male ; Mice ; Microscopy, Electron ; Microvessels/cytology ; Neurodegenerative Diseases/etiology ; Neurodegenerative Diseases/pathology ; Neurodegenerative Diseases/physiopathology ; Neuroprotective Agents/therapeutic use ; Primary Cell Culture ; Survivors
Czasopismo naukowe
Tytuł :
Protective effect of (Xenical+GSF) against I/R-induced blood brain barrier disruption, ionic edema, lipid deregulation and neuroinflammation.
Autorzy :
Kadri S; Bioactive Substances Laboratory, Biotechnology Centre, Technopolis Borj-Cedria, BP-901, 2050 Hammam-Lif, Tunis, Tunisia. Electronic address: .
El Ayed M; Bioactive Substances Laboratory, Biotechnology Centre, Technopolis Borj-Cedria, BP-901, 2050 Hammam-Lif, Tunis, Tunisia.
Limam F; Bioactive Substances Laboratory, Biotechnology Centre, Technopolis Borj-Cedria, BP-901, 2050 Hammam-Lif, Tunis, Tunisia.
Aouani E; Bioactive Substances Laboratory, Biotechnology Centre, Technopolis Borj-Cedria, BP-901, 2050 Hammam-Lif, Tunis, Tunisia.
Mokni M; Bioactive Substances Laboratory, Biotechnology Centre, Technopolis Borj-Cedria, BP-901, 2050 Hammam-Lif, Tunis, Tunisia.
Pokaż więcej
Źródło :
Microvascular research [Microvasc Res] 2020 Nov; Vol. 132, pp. 104054. Date of Electronic Publication: 2020 Aug 05.
Typ publikacji :
Journal Article
MeSH Terms :
Anti-Inflammatory Agents/*pharmacology
Blood-Brain Barrier/*drug effects
Brain Edema/*prevention & control
Capillary Permeability/*drug effects
Grape Seed Extract/*pharmacology
Lipid Metabolism/*drug effects
Lipid Regulating Agents/*pharmacology
Neuroprotective Agents/*pharmacology
Orlistat/*pharmacology
Reperfusion Injury/*prevention & control
Stroke/*prevention & control
Animals ; Blood-Brain Barrier/metabolism ; Blood-Brain Barrier/ultrastructure ; Brain Edema/metabolism ; Brain Edema/pathology ; Disease Models, Animal ; Inflammation Mediators/metabolism ; Male ; Rats, Wistar ; Reperfusion Injury/metabolism ; Reperfusion Injury/pathology ; Stroke/metabolism ; Stroke/pathology
Czasopismo naukowe
Tytuł :
Possible routes of SARS-CoV-2 invasion in brain: In context of neurological symptoms in COVID-19 patients.
Autorzy :
Kumar A; Etiologically Elusive Disorders Research Network (EEDRN), New Delhi, India.; Department of Anatomy, All India Institute of Medical Sciences (AIIMS), Patna, India.
Pareek V; Etiologically Elusive Disorders Research Network (EEDRN), New Delhi, India.; National Brain Research Center, Manesar, India.
Prasoon P; Etiologically Elusive Disorders Research Network (EEDRN), New Delhi, India.; Pittsburgh Center for Pain Research, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Faiq MA; Etiologically Elusive Disorders Research Network (EEDRN), New Delhi, India.; New York University (NYU) Langone Health Center, NYU Robert I Grossman School of Medicine, New York, NY, USA.
Kumar P; Etiologically Elusive Disorders Research Network (EEDRN), New Delhi, India.; Department of Pediatrics, Medical University of South Carolina, Charleston, SC, USA.
Kumari C; Etiologically Elusive Disorders Research Network (EEDRN), New Delhi, India.; Department of Anatomy, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
Narayan RK; Etiologically Elusive Disorders Research Network (EEDRN), New Delhi, India.; Department of Anatomy, All India Institute of Medical Sciences (AIIMS), Patna, India.
Pokaż więcej
Źródło :
Journal of neuroscience research [J Neurosci Res] 2020 Dec; Vol. 98 (12), pp. 2376-2383. Date of Electronic Publication: 2020 Aug 31.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Betacoronavirus/*metabolism
Blood-Brain Barrier/*metabolism
Brain/*metabolism
Coronavirus Infections/*metabolism
Nervous System Diseases/*metabolism
Olfactory Nerve/*metabolism
Pneumonia, Viral/*metabolism
Animals ; Blood-Brain Barrier/virology ; Brain/virology ; COVID-19 ; Coronavirus Infections/complications ; Coronavirus Infections/transmission ; Humans ; Nervous System Diseases/etiology ; Olfactory Nerve/virology ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/transmission ; SARS-CoV-2
Czasopismo naukowe
Tytuł :
The SARS-CoV-2 spike protein alters barrier function in 2D static and 3D microfluidic in-vitro models of the human blood-brain barrier.
Autorzy :
Buzhdygan TP; Department of Pathology and Laboratory Medicine, The Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, United States of America; Center for Substance Abuse Research, The Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, United States of America.
DeOre BJ; Department of Biomedical Engineering, Rowan University, Glassboro, NJ 08028, United States of America.
Baldwin-Leclair A; Department of Biomedical Engineering, Rowan University, Glassboro, NJ 08028, United States of America.
Bullock TA; Department of Pathology and Laboratory Medicine, The Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, United States of America; Center for Substance Abuse Research, The Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, United States of America.
McGary HM; Department of Pathology and Laboratory Medicine, The Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, United States of America.
Khan JA; Department of Pathology and Laboratory Medicine, The Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, United States of America.
Razmpour R; Department of Pathology and Laboratory Medicine, The Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, United States of America.
Hale JF; Department of Pathology and Laboratory Medicine, The Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, United States of America.
Galie PA; Department of Biomedical Engineering, Rowan University, Glassboro, NJ 08028, United States of America.
Potula R; Department of Pathology and Laboratory Medicine, The Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, United States of America; Center for Substance Abuse Research, The Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, United States of America.
Andrews AM; Department of Pathology and Laboratory Medicine, The Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, United States of America; Center for Substance Abuse Research, The Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, United States of America.
Ramirez SH; Department of Pathology and Laboratory Medicine, The Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, United States of America; Center for Substance Abuse Research, The Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, United States of America; The Shriners Hospitals Pediatric Research Center, Philadelphia, PA 19140, United States of America. Electronic address: .
Pokaż więcej
Źródło :
Neurobiology of disease [Neurobiol Dis] 2020 Dec; Vol. 146, pp. 105131. Date of Electronic Publication: 2020 Oct 11.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Angiotensin-Converting Enzyme 2/*metabolism
Blood-Brain Barrier/*metabolism
Capillary Permeability/*physiology
Endothelial Cells/*metabolism
Inflammation/*metabolism
Matrix Metalloproteinases/*metabolism
SARS-CoV-2/*pathogenicity
Spike Glycoprotein, Coronavirus/*physiology
Blood-Brain Barrier/drug effects ; COVID-19 ; Capillary Permeability/drug effects ; Cell Adhesion Molecules/drug effects ; Cell Adhesion Molecules/metabolism ; Cell Survival/drug effects ; Dementia/metabolism ; Electric Impedance ; Endothelial Cells/drug effects ; Frontal Lobe/metabolism ; Humans ; Hypertension/metabolism ; In Vitro Techniques ; Intercellular Junctions/metabolism ; Interleukin-6/genetics ; Interleukin-6/metabolism ; Lab-On-A-Chip Devices ; Matrix Metalloproteinases/drug effects ; Primary Cell Culture ; Protein Domains ; Protein Subunits/metabolism ; Protein Subunits/pharmacology ; RNA, Messenger/drug effects ; RNA, Messenger/metabolism ; Spike Glycoprotein, Coronavirus/pharmacology
Czasopismo naukowe
Tytuł :
JLX001 attenuates blood-brain barrier dysfunction in MCAO/R rats via activating the Wnt/β-catenin signaling pathway.
Autorzy :
Zhao B; State key laboratory of Nature Medicines, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 210009, PR China.
Zhu J; State key laboratory of Nature Medicines, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 210009, PR China.
Fei Y; State key laboratory of Nature Medicines, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 210009, PR China.
Yin Q; State key laboratory of Nature Medicines, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 210009, PR China.
Shen W; School of Sciences, China Pharmaceutical University, Nanjing 210009, PR China.
Liang B; Jiangsu Jinglixin Pharmaceutical Technology Company Limited, Nanjing 211100, PR china.
Zhu X; School of Sciences, China Pharmaceutical University, Nanjing 210009, PR China. Electronic address: .
Li Y; State key laboratory of Nature Medicines, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 210009, PR China. Electronic address: .
Pokaż więcej
Źródło :
Life sciences [Life Sci] 2020 Nov 01; Vol. 260, pp. 118221. Date of Electronic Publication: 2020 Aug 05.
Typ publikacji :
Journal Article
MeSH Terms :
Infarction, Middle Cerebral Artery*
Blood-Brain Barrier/*drug effects
Brain Ischemia/*physiopathology
Triterpenes/*administration & dosage
Wnt Signaling Pathway/*drug effects
Animals ; Blood-Brain Barrier/physiology ; Cell Survival/drug effects ; Cerebral Cortex/chemistry ; Endothelial Cells/chemistry ; Endothelial Cells/physiology ; Glucaric Acid/administration & dosage ; Male ; Matrix Metalloproteinase 9/analysis ; Matrix Metalloproteinase 9/metabolism ; Microvessels/cytology ; Neuroprotective Agents ; Oxygen/administration & dosage ; Platelet Aggregation Inhibitors ; Rats ; Rats, Sprague-Dawley ; Reperfusion ; Triterpenes/pharmacology ; Wnt Signaling Pathway/physiology
Czasopismo naukowe
Tytuł :
Expression of VEGF- and tight junction-related proteins in the neocortical microvasculature of patients with drug-resistant temporal lobe epilepsy.
Autorzy :
Castañeda-Cabral JL; Departamento de Farmacobiología, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (Cinvestav) Sede Sur, Ciudad de México, Mexico; Departamento de Biología Celular y Molecular, Centro Universitario de Ciencias Biológicas y Agropecuarias (CUCBA), Universidad de Guadalajara, Zapopan, Mexico. Electronic address: .
Colunga-Durán A; Departamento de Farmacobiología, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (Cinvestav) Sede Sur, Ciudad de México, Mexico.
Ureña-Guerrero ME; Departamento de Biología Celular y Molecular, Centro Universitario de Ciencias Biológicas y Agropecuarias (CUCBA), Universidad de Guadalajara, Zapopan, Mexico.
Beas-Zárate C; Departamento de Biología Celular y Molecular, Centro Universitario de Ciencias Biológicas y Agropecuarias (CUCBA), Universidad de Guadalajara, Zapopan, Mexico.
Nuñez-Lumbreras MLA; Departamento de Farmacobiología, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (Cinvestav) Sede Sur, Ciudad de México, Mexico.
Orozco-Suárez S; Unidad de Investigación Médica en Enfermedades Neurológicas, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, IMSS, Ciudad de México, Mexico.
Alonso-Vanegas M; Servicio de Neurocirugía, Instituto Nacional de Neurología y Neurocirugía 'Manuel Velasco Suárez' (INNNMVS), Ciudad de México, Mexico.
Guevara-Guzmán R; Departamento de Fisiología, Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad de México, Mexico.
Deli MA; Institute of Biophysics, Biological Research Centre, Hungarian Academy of Sciences, Szeged, Hungary.
Valle-Dorado MG; Departamento de Farmacobiología, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (Cinvestav) Sede Sur, Ciudad de México, Mexico.
Sánchez-Valle V; Departamento de Farmacología, Cinvestav, Ciudad de México, Mexico.
Rocha L; Departamento de Farmacobiología, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (Cinvestav) Sede Sur, Ciudad de México, Mexico.
Pokaż więcej
Źródło :
Microvascular research [Microvasc Res] 2020 Nov; Vol. 132, pp. 104059. Date of Electronic Publication: 2020 Aug 13.
Typ publikacji :
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Blood-Brain Barrier/*metabolism
Drug Resistant Epilepsy/*metabolism
Epilepsy, Temporal Lobe/*metabolism
Microvessels/*metabolism
Neocortex/*blood supply
Tight Junction Proteins/*metabolism
Tight Junctions/*metabolism
Vascular Endothelial Growth Factor A/*metabolism
Adolescent ; Adult ; Blood-Brain Barrier/pathology ; Claudin-5/metabolism ; Drug Resistant Epilepsy/drug therapy ; Drug Resistant Epilepsy/pathology ; Epilepsy, Temporal Lobe/drug therapy ; Epilepsy, Temporal Lobe/pathology ; Female ; Humans ; Male ; Microvessels/pathology ; Middle Aged ; Occludin/metabolism ; Signal Transduction ; Tight Junctions/pathology ; Vascular Endothelial Growth Factor Receptor-2/metabolism ; Young Adult ; Zonula Occludens-1 Protein/metabolism
Czasopismo naukowe
Tytuł :
Three-dimensional induced pluripotent stem-cell models of human brain angiogenesis.
Autorzy :
Linville RM; Institute for Nanobiotechnology, Johns Hopkins University, Baltimore, MD, United States of America; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, United States of America.
Arevalo D; Institute for Nanobiotechnology, Johns Hopkins University, Baltimore, MD, United States of America; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, United States of America.
Maressa JC; Institute for Nanobiotechnology, Johns Hopkins University, Baltimore, MD, United States of America; Department of Materials Science and Engineering, Johns Hopkins University, Baltimore, MD, United States of America.
Zhao N; Institute for Nanobiotechnology, Johns Hopkins University, Baltimore, MD, United States of America.
Searson PC; Institute for Nanobiotechnology, Johns Hopkins University, Baltimore, MD, United States of America; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, United States of America; Department of Materials Science and Engineering, Johns Hopkins University, Baltimore, MD, United States of America. Electronic address: .
Pokaż więcej
Źródło :
Microvascular research [Microvasc Res] 2020 Nov; Vol. 132, pp. 104042. Date of Electronic Publication: 2020 Jul 14.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Cell Differentiation*/drug effects
Neovascularization, Physiologic*/drug effects
Blood-Brain Barrier/*physiology
Brain/*blood supply
Endothelial Cells/*physiology
Induced Pluripotent Stem Cells/*physiology
Angiogenesis Inducing Agents/pharmacology ; Blood-Brain Barrier/drug effects ; Cell Culture Techniques ; Cells, Cultured ; Endothelial Cells/drug effects ; Extracellular Matrix/physiology ; Humans ; Induced Pluripotent Stem Cells/drug effects ; Models, Cardiovascular ; Neovascularization, Pathologic ; Oxidative Stress ; Phenotype ; Wnt Signaling Pathway
Czasopismo naukowe
Tytuł :
The molecular anatomy and functions of the choroid plexus in healthy and diseased brain.
Autorzy :
Kratzer I; FLUID Team, Lyon Neurosciences Research Center, INSERM U1028 CNRS UMR 5292, University Claude Bernard Lyon 1, 69008 Lyon, France; Friedensgasse 3, 8010 Graz, Austria. Electronic address: .
Ek J; Department of Physiology, Institute of Neuroscience and Physiology, University of Gothenburg, Medicinaregatan 11, Box 432, 40530 Göteborg, Sweden. Electronic address: .
Stolp H; Department of Comparative Biomedical Sciences, Royal Veterinary College, London NW0 1TU, UK. Electronic address: .
Pokaż więcej
Źródło :
Biochimica et biophysica acta. Biomembranes [Biochim Biophys Acta Biomembr] 2020 Nov 01; Vol. 1862 (11), pp. 183430. Date of Electronic Publication: 2020 Aug 01.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Alzheimer Disease*/immunology
Alzheimer Disease*/pathology
Blood-Brain Barrier*/immunology
Blood-Brain Barrier*/pathology
Choroid Plexus*/immunology
Choroid Plexus*/pathology
Epithelial Cells*/immunology
Epithelial Cells*/pathology
Multiple Sclerosis*/immunology
Multiple Sclerosis*/pathology
Gene Expression Regulation/*immunology
Humans
Czasopismo naukowe
Tytuł :
Desert Hedgehog-Driven Endothelium Integrity Is Enhanced by Gas1 (Growth Arrest-Specific 1) but Negatively Regulated by Cdon (Cell Adhesion Molecule-Related/Downregulated by Oncogenes).
Autorzy :
Chapouly C; University of Bordeaux, Inserm, Biology of Cardiovascular Diseases, U1034, F-33604 Pessac, France.
Hollier PL; University of Bordeaux, Inserm, Biology of Cardiovascular Diseases, U1034, F-33604 Pessac, France.
Guimbal S; University of Bordeaux, Inserm, Biology of Cardiovascular Diseases, U1034, F-33604 Pessac, France.
Cornuault L; University of Bordeaux, Inserm, Biology of Cardiovascular Diseases, U1034, F-33604 Pessac, France.
Gadeau AP; University of Bordeaux, Inserm, Biology of Cardiovascular Diseases, U1034, F-33604 Pessac, France.
Renault MA; University of Bordeaux, Inserm, Biology of Cardiovascular Diseases, U1034, F-33604 Pessac, France.
Pokaż więcej
Źródło :
Arteriosclerosis, thrombosis, and vascular biology [Arterioscler Thromb Vasc Biol] 2020 Dec; Vol. 40 (12), pp. e336-e349. Date of Electronic Publication: 2020 Oct 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Blood-Brain Barrier/*metabolism
Cell Adhesion Molecules/*metabolism
Cell Cycle Proteins/*metabolism
Corneal Neovascularization/*metabolism
Endothelial Cells/*metabolism
Endothelium, Corneal/*metabolism
Hedgehog Proteins/*metabolism
Inflammation/*metabolism
Animals ; Antigens, CD/genetics ; Antigens, CD/metabolism ; Blood-Brain Barrier/pathology ; Cadherins/genetics ; Cadherins/metabolism ; Cell Adhesion Molecules/deficiency ; Cell Adhesion Molecules/genetics ; Cell Cycle Proteins/deficiency ; Cell Cycle Proteins/genetics ; Cells, Cultured ; Corneal Neovascularization/genetics ; Corneal Neovascularization/pathology ; Disease Models, Animal ; Endothelial Cells/pathology ; Endothelium, Corneal/pathology ; Female ; GPI-Linked Proteins/deficiency ; GPI-Linked Proteins/genetics ; GPI-Linked Proteins/metabolism ; Hedgehog Proteins/genetics ; Humans ; Inflammation/genetics ; Inflammation/pathology ; Male ; Mice, 129 Strain ; Mice, Inbred C57BL ; Mice, Knockout ; Patched-1 Receptor/metabolism ; Signal Transduction ; Smoothened Receptor/metabolism
Czasopismo naukowe
Tytuł :
Blood-brain barrier permeability analysis of plant ceramides.
Autorzy :
Eguchi K; Innovation and Business Development Headquarters, Daicel Corporation, Tokyo, Japan.
Mikami D; Lipid Biofunction Section, Faculty of Advanced Life Science, Hokkaido University, Sapporo, Hokkaido, Japan.
Sun H; Lipid Biofunction Section, Faculty of Advanced Life Science, Hokkaido University, Sapporo, Hokkaido, Japan.
Tsumita T; Department of Vascular Biology and Molecular Pathology, Hokkaido University Graduate School of Dental Medicine, Sapporo, Hokkaido, Japan.
Takahashi K; Innovation and Business Development Headquarters, Daicel Corporation, Tokyo, Japan.
Mukai K; Innovation and Business Development Headquarters, Daicel Corporation, Tokyo, Japan.; Lipid Biofunction Section, Faculty of Advanced Life Science, Hokkaido University, Sapporo, Hokkaido, Japan.
Yuyama K; Lipid Biofunction Section, Faculty of Advanced Life Science, Hokkaido University, Sapporo, Hokkaido, Japan.
Igarashi Y; Lipid Biofunction Section, Faculty of Advanced Life Science, Hokkaido University, Sapporo, Hokkaido, Japan.
Pokaż więcej
Źródło :
PloS one [PLoS One] 2020 Nov 02; Vol. 15 (11), pp. e0241640. Date of Electronic Publication: 2020 Nov 02 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Capillary Permeability*
Blood-Brain Barrier/*drug effects
Ceramides/*pharmacology
Ethanolamines/*pharmacology
Animals ; Blood-Brain Barrier/metabolism ; Cells, Cultured ; Mice ; Mice, Inbred BALB C ; Sphingomyelins/metabolism
Czasopismo naukowe
Tytuł :
SARS-CoV-2-mediated encephalitis: Role of AT2R receptors in the blood-brain barrier.
Autorzy :
de Sousa AK; Laboratory of Experimental Physiopharmacology (LAFFEX), Federal University of the Delta of Parnaíba, Parnaíba, PI, Brazil.
Magalhães DA; Laboratory of Experimental Physiopharmacology (LAFFEX), Federal University of the Delta of Parnaíba, Parnaíba, PI, Brazil; The Northeast Biotechnology Network, Federal University of Piauí, Teresina, Brazil.
Ferreira JDS; Laboratory of Experimental Physiopharmacology (LAFFEX), Federal University of the Delta of Parnaíba, Parnaíba, PI, Brazil.
Barbosa ALDR; Laboratory of Experimental Physiopharmacology (LAFFEX), Federal University of the Delta of Parnaíba, Parnaíba, PI, Brazil; The Northeast Biotechnology Network, Federal University of Piauí, Teresina, Brazil. Electronic address: .
Pokaż więcej
Źródło :
Medical hypotheses [Med Hypotheses] 2020 Nov; Vol. 144, pp. 110213. Date of Electronic Publication: 2020 Aug 26.
Typ publikacji :
Journal Article
MeSH Terms :
Blood-Brain Barrier/*physiopathology
COVID-19/*complications
Encephalitis, Viral/*etiology
Receptor, Angiotensin, Type 2/*physiology
Angiotensin-Converting Enzyme 2/physiology ; Blood-Brain Barrier/virology ; COVID-19/physiopathology ; COVID-19/virology ; Encephalitis, Viral/physiopathology ; Encephalitis, Viral/virology ; Host Microbial Interactions/physiology ; Humans ; Models, Neurological ; Pandemics ; SARS-CoV-2/pathogenicity
Czasopismo naukowe
Tytuł :
The potential role of microvascular pathology in the neurological manifestations of coronavirus infection.
Autorzy :
MacLean MA; Division of Neurosurgery, Dalhousie University, Queen Elizabeth II Health Sciences Centre (Halifax Infirmary), 1796 Summer Street, Halifax, NS, B3H 3A7, Canada. .
Kamintsky L; Department of Medical Neuroscience, Faculty of Medicine, Dalhousie University, Room 12 H, 12th Floor, Sir Charles Tupper Building, 5850 College Street, PO Box 15000, Halifax, NS, Canada.
Leck ED; Division of Neurosurgery, Dalhousie University, Queen Elizabeth II Health Sciences Centre (Halifax Infirmary), 1796 Summer Street, Halifax, NS, B3H 3A7, Canada.
Friedman A; Department of Medical Neuroscience, Faculty of Medicine, Dalhousie University, Room 12 H, 12th Floor, Sir Charles Tupper Building, 5850 College Street, PO Box 15000, Halifax, NS, Canada.
Pokaż więcej
Źródło :
Fluids and barriers of the CNS [Fluids Barriers CNS] 2020 Sep 10; Vol. 17 (1), pp. 55. Date of Electronic Publication: 2020 Sep 10.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Blood-Brain Barrier/*physiopathology
Coronavirus Infections/*physiopathology
Inflammation/*physiopathology
Microvessels/*physiopathology
Nervous System Diseases/*physiopathology
Pneumonia, Viral/*physiopathology
Betacoronavirus ; Blood-Brain Barrier/immunology ; Blood-Brain Barrier/virology ; COVID-19 ; Cardiovascular Diseases/physiopathology ; Coronavirus Infections/immunology ; Cytokines/immunology ; Diabetes Mellitus/physiopathology ; Encephalitis/immunology ; Encephalitis/physiopathology ; Humans ; Inflammation/immunology ; Microvessels/immunology ; Nervous System Diseases/immunology ; Pandemics ; Pneumonia, Viral/immunology ; SARS-CoV-2 ; Seizures/immunology ; Seizures/physiopathology ; Stroke/immunology ; Stroke/physiopathology ; Thromboembolism/immunology ; Thromboembolism/physiopathology
Czasopismo naukowe
Tytuł :
Chinese medicine Tongxinluo capsule protects against blood-brain barrier disruption after ischemic stroke by inhibiting the low-density lipoprotein receptor-related protein 1 pathway in mice.
Autorzy :
Chang L; National Key Laboratory of Collateral Disease Research and Innovative Chinese Medicine, Hebei Yiling Chinese Medicine Research Institute, Shijiazhuang, China. Electronic address: .
Hu L; Department of Medical Imaging, The First Affiliated Hospital of Shandong First Medical University, Jinan, China. Electronic address: .
Wei C; National Key Laboratory of Collateral Disease Research and Innovative Chinese Medicine, Hebei Yiling Chinese Medicine Research Institute, Shijiazhuang, China. Electronic address: .
Zhang H; Department of Endocrinology, The First Affiliated Hospital of Henan University of Chinese Medicine, China. Electronic address: .
Liu S; National Key Laboratory of Collateral Disease Research and Innovative Chinese Medicine, Hebei Yiling Chinese Medicine Research Institute, Shijiazhuang, China; Department of Rehabilitation Medicine, The First Affiliated Hospital of Shandong First Medical University, No.16766 Jingshi Road, Jinan, Shandong, China. Electronic address: .
Pokaż więcej
Źródło :
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association [J Stroke Cerebrovasc Dis] 2020 Sep; Vol. 29 (9), pp. 105071. Date of Electronic Publication: 2020 Jun 30.
Typ publikacji :
Journal Article
MeSH Terms :
Blood-Brain Barrier/*drug effects
Capillary Permeability/*drug effects
Drugs, Chinese Herbal/*administration & dosage
Infarction, Middle Cerebral Artery/*drug therapy
Low Density Lipoprotein Receptor-Related Protein-1/*metabolism
Administration, Oral ; Animals ; Blood-Brain Barrier/metabolism ; Blood-Brain Barrier/pathology ; Blood-Brain Barrier/physiopathology ; Capsules ; Disease Models, Animal ; Infarction, Middle Cerebral Artery/metabolism ; Infarction, Middle Cerebral Artery/pathology ; Infarction, Middle Cerebral Artery/physiopathology ; Male ; Mice, Inbred C57BL ; Signal Transduction ; Tight Junction Proteins/metabolism ; Tight Junctions/drug effects ; Tight Junctions/metabolism ; Tight Junctions/pathology
Czasopismo naukowe
Tytuł :
Redox signalling and regulation of the blood-brain barrier.
Autorzy :
van Leeuwen E; Centre for Free Radical Research, Department of Pathology and Biomedical Science, University of Otago, Christchurch, New Zealand.
Hampton MB; Centre for Free Radical Research, Department of Pathology and Biomedical Science, University of Otago, Christchurch, New Zealand.
Smyth LCD; Centre for Free Radical Research, Department of Pathology and Biomedical Science, University of Otago, Christchurch, New Zealand. Electronic address: .
Pokaż więcej
Źródło :
The international journal of biochemistry & cell biology [Int J Biochem Cell Biol] 2020 Aug; Vol. 125, pp. 105794. Date of Electronic Publication: 2020 Jun 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Blood-Brain Barrier/*cytology
Inflammation/*metabolism
Nervous System Diseases/*metabolism
Oxidative Stress/*physiology
Animals ; Astrocytes/metabolism ; Astrocytes/pathology ; Blood-Brain Barrier/enzymology ; Blood-Brain Barrier/metabolism ; Cell Death/drug effects ; Endothelial Cells/enzymology ; Endothelial Cells/metabolism ; Humans ; Inflammation/enzymology ; Inflammation/immunology ; Microglia/enzymology ; Microglia/metabolism ; Nervous System Diseases/enzymology ; Nervous System Diseases/physiopathology ; Neutrophils/enzymology ; Neutrophils/metabolism ; Oxidation-Reduction/drug effects ; Oxidative Stress/drug effects ; Pericytes/enzymology ; Pericytes/metabolism ; Pericytes/pathology ; Signal Transduction/genetics
Czasopismo naukowe
Tytuł :
The effects of point-source electroporation on the blood-brain barrier and brain vasculature in rats: An MRI and histology study.
Autorzy :
Sharabi S; The Advanced Technology Center, Sheba Medical Center, Ramat-Gan 52621, Israel. Electronic address: .
Last D; The Advanced Technology Center, Sheba Medical Center, Ramat-Gan 52621, Israel.
Daniels D; The Advanced Technology Center, Sheba Medical Center, Ramat-Gan 52621, Israel.
Liraz Zaltsman S; The Joseph Sagol Neuroscience Center, Sheba Medical Center, Tel Hashomer, Ramat Gan, Israel; GandFaculty of Health Profession, Ono Academic College, Kiryat Ono, Israel; Department of Pharmacology, Institute for Drug Research, Hebrew University, Jerusalem, Israel.
Mardor Y; The Advanced Technology Center, Sheba Medical Center, Ramat-Gan 52621, Israel; Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
Pokaż więcej
Źródło :
Bioelectrochemistry (Amsterdam, Netherlands) [Bioelectrochemistry] 2020 Aug; Vol. 134, pp. 107521. Date of Electronic Publication: 2020 Mar 31.
Typ publikacji :
Journal Article
MeSH Terms :
Electroporation*
Blood-Brain Barrier/*diagnostic imaging
Blood-Brain Barrier/*metabolism
Brain/*blood supply
Brain/*diagnostic imaging
Animals ; Blood-Brain Barrier/cytology ; Brain/cytology ; Brain/metabolism ; Magnetic Resonance Imaging ; Male ; Rats
Czasopismo naukowe
Tytuł :
Angiopoietin-1/Tie-2 signal after focal traumatic brain injury is potentiated by BQ788, an ET B receptor antagonist, in the mouse cerebrum: Involvement in recovery of blood-brain barrier function.
Autorzy :
Michinaga S; Laboratory of Pharmacology, Faculty of Pharmacy, Osaka Ohtani University, Tondabayashi, Osaka, Japan.
Tanabe A; Laboratory of Pharmacology, Faculty of Pharmacy, Osaka Ohtani University, Tondabayashi, Osaka, Japan.
Nakaya R; Laboratory of Pharmacology, Faculty of Pharmacy, Osaka Ohtani University, Tondabayashi, Osaka, Japan.
Fukutome C; Laboratory of Pharmacology, Faculty of Pharmacy, Osaka Ohtani University, Tondabayashi, Osaka, Japan.
Inoue A; Laboratory of Pharmacology, Faculty of Pharmacy, Osaka Ohtani University, Tondabayashi, Osaka, Japan.
Iwane A; Laboratory of Pharmacology, Faculty of Pharmacy, Osaka Ohtani University, Tondabayashi, Osaka, Japan.
Minato Y; Laboratory of Pharmacology, Faculty of Pharmacy, Osaka Ohtani University, Tondabayashi, Osaka, Japan.
Tujiuchi Y; Laboratory of Pharmacology, Faculty of Pharmacy, Osaka Ohtani University, Tondabayashi, Osaka, Japan.
Miyake D; Laboratory of Pharmacology, Faculty of Pharmacy, Osaka Ohtani University, Tondabayashi, Osaka, Japan.
Mizuguchi H; Laboratory of Pharmacology, Faculty of Pharmacy, Osaka Ohtani University, Tondabayashi, Osaka, Japan.
Koyama Y; Laboratory of Pharmacology, Kobe Pharmaceutical University, Kobe, Japan.
Pokaż więcej
Źródło :
Journal of neurochemistry [J Neurochem] 2020 Aug; Vol. 154 (3), pp. 330-348. Date of Electronic Publication: 2020 Jan 27.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Angiopoietin-1/*metabolism
Blood-Brain Barrier/*drug effects
Brain Injuries, Traumatic/*metabolism
Endothelin B Receptor Antagonists/*pharmacology
Oligopeptides/*pharmacology
Piperidines/*pharmacology
Receptor, TIE-2/*metabolism
Animals ; Blood-Brain Barrier/metabolism ; Blood-Brain Barrier/pathology ; Cerebrum/drug effects ; Cerebrum/injuries ; Cerebrum/metabolism ; Male ; Mice
Czasopismo naukowe
Tytuł :
Carbamazepine induces a bioenergetics disruption to microvascular endothelial cells from the blood-brain barrier.
Autorzy :
Alelwani W; Department of Biochemistry, College of Science, University of Jeddah, Jeddah 80203, Saudi Arabia.
Elmorsy E; Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Mansoura University, Mansoura, Egypt; School of Medicine, University of Nottingham, Royal Derby Hospital Centre, Derby, UK.
Kattan SW; Medical Laboratory Department, College of Applied Medical Sciences, Taibah University, Yanbu, Saudi Arabia.
Babteen NA; Department of Biochemistry, College of Science, University of Jeddah, Jeddah 80203, Saudi Arabia.
Alnajeebi AM; Department of Biochemistry, College of Science, University of Jeddah, Jeddah 80203, Saudi Arabia.
Al-Ghafari A; Biochemistry Department, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.
Carter WG; School of Medicine, University of Nottingham, Royal Derby Hospital Centre, Derby, UK. Electronic address: .
Pokaż więcej
Źródło :
Toxicology letters [Toxicol Lett] 2020 Oct 15; Vol. 333, pp. 184-191. Date of Electronic Publication: 2020 Aug 14.
Typ publikacji :
Journal Article
MeSH Terms :
Anticonvulsants/*toxicity
Blood-Brain Barrier/*drug effects
Carbamazepine/*toxicity
Endothelial Cells/*drug effects
Energy Metabolism/*drug effects
Microvessels/*drug effects
Adenosine Triphosphate/metabolism ; Animals ; Blood-Brain Barrier/metabolism ; Cell Survival/drug effects ; Cells, Cultured ; Dose-Response Relationship, Drug ; Endothelial Cells/metabolism ; Membrane Potential, Mitochondrial/drug effects ; Microvessels/metabolism ; Mitochondria/drug effects ; Mitochondria/metabolism ; Rats, Wistar
Czasopismo naukowe
Tytuł :
Study of the neurotoxicity of indoor airborne nanoparticles based on a 3D human blood-brain barrier chip.
Autorzy :
Li Y; Key Laboratory for Deep Processing of Major Grain and Oil (The Chinese Ministry of Education), College of Food Science and Engineering, Wuhan Polytechnic University, Wuhan 430023, PR China.
Liu Y; Key Laboratory for Deep Processing of Major Grain and Oil (The Chinese Ministry of Education), College of Food Science and Engineering, Wuhan Polytechnic University, Wuhan 430023, PR China.
Hu C; State Key Laboratory of Silicate Materials for Architectures, Wuhan University of Technology, Wuhan 430070, PR China.
Chang Q; Department of Chemical and Biomolecular Engineering, Hong Kong University of Science & Technology, Clear Water Bay, Kowloon, Hong Kong, China.
Deng Q; XiangYa School of Public Health, Central South University, Changsha 410083, PR China.
Yang X; XiangYa School of Public Health, Central South University, Changsha 410083, PR China; Lab of Environmental Biomedicine, School of Life Sciences, Central China Normal University, Wuhan 430079, PR China. Electronic address: .
Wu Y; Key Laboratory for Deep Processing of Major Grain and Oil (The Chinese Ministry of Education), College of Food Science and Engineering, Wuhan Polytechnic University, Wuhan 430023, PR China; Hubei Key Laboratory for Processing and Transformation of Agricultural Products, College of Food Science and Engineering, Wuhan Polytechnic University, Wuhan, 430023, PR China. Electronic address: .
Pokaż więcej
Źródło :
Environment international [Environ Int] 2020 Oct; Vol. 143, pp. 105598. Date of Electronic Publication: 2020 Jul 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Blood-Brain Barrier*/metabolism
Lab-On-A-Chip Devices*
Nanoparticles*/toxicity
Animals ; Endothelial Cells/metabolism ; Humans ; Kelch-Like ECH-Associated Protein 1 ; NF-E2-Related Factor 2 ; Oxidative Stress ; Reactive Oxygen Species/metabolism
Czasopismo naukowe
Tytuł :
Non-invasive molecularly-specific millimeter-resolution manipulation of brain circuits by ultrasound-mediated aggregation and uncaging of drug carriers.
Autorzy :
Ozdas MS; Institute of Neuroinformatics, D-ITET, ETH Zurich and UZH, Zurich, Switzerland.; Neuroscience Center, Zurich, Switzerland.
Shah AS; Institute of Neuroinformatics, D-ITET, ETH Zurich and UZH, Zurich, Switzerland. .; Neuroscience Center, Zurich, Switzerland. .
Johnson PM; Institute of Neuroinformatics, D-ITET, ETH Zurich and UZH, Zurich, Switzerland.; Neuroscience Center, Zurich, Switzerland.
Patel N; Institute of Neuroinformatics, D-ITET, ETH Zurich and UZH, Zurich, Switzerland.
Marks M; Institute of Neuroinformatics, D-ITET, ETH Zurich and UZH, Zurich, Switzerland.; Neuroscience Center, Zurich, Switzerland.
Yasar TB; Institute of Neuroinformatics, D-ITET, ETH Zurich and UZH, Zurich, Switzerland.; Neuroscience Center, Zurich, Switzerland.
Stalder U; Department of Chemistry, UZH, Zurich, Switzerland.
Bigler L; Department of Chemistry, UZH, Zurich, Switzerland.
von der Behrens W; Institute of Neuroinformatics, D-ITET, ETH Zurich and UZH, Zurich, Switzerland.; Neuroscience Center, Zurich, Switzerland.
Sirsi SR; Institute of Neuroinformatics, D-ITET, ETH Zurich and UZH, Zurich, Switzerland.; Department of Bioengineering, UT at Dallas, Richardson, USA.
Yanik MF; Institute of Neuroinformatics, D-ITET, ETH Zurich and UZH, Zurich, Switzerland. .; Neuroscience Center, Zurich, Switzerland. .
Pokaż więcej
Źródło :
Nature communications [Nat Commun] 2020 Oct 01; Vol. 11 (1), pp. 4929. Date of Electronic Publication: 2020 Oct 01.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Blood-Brain Barrier/*metabolism
Brain Diseases/*drug therapy
Drug Carriers/*radiation effects
GABA-A Receptor Agonists/*administration & dosage
Ultrasonography, Interventional/*methods
Animals ; Blood-Brain Barrier/diagnostic imaging ; Blood-Brain Barrier/radiation effects ; Dose-Response Relationship, Radiation ; Drug Carriers/chemistry ; Drug Carriers/pharmacokinetics ; Female ; GABA-A Receptor Agonists/pharmacokinetics ; Humans ; Magnetic Resonance Imaging ; Models, Animal ; Muscimol/administration & dosage ; Muscimol/pharmacokinetics ; Rats ; Stereotaxic Techniques ; Ultrasonic Waves
Czasopismo naukowe
Tytuł :
Lysophosphatidic acid increased infarct size in the early stage of cerebral ischemia-reperfusion with increased BBB permeability.
Autorzy :
Chi OZ; Department of Anesthesiology and Perioperative Medicine, Rutgers Robert Wood Johnson Medical School, 125 Paterson Street, Suite 3100, New Brunswick, NJ 08901-1977, USA. Electronic address: .
Mellender SJ; Department of Anesthesiology and Perioperative Medicine, Rutgers Robert Wood Johnson Medical School, 125 Paterson Street, Suite 3100, New Brunswick, NJ 08901-1977, USA.
Kiss GK; Department of Anesthesiology and Perioperative Medicine, Rutgers Robert Wood Johnson Medical School, 125 Paterson Street, Suite 3100, New Brunswick, NJ 08901-1977, USA.
Chiricolo A; Department of Anesthesiology and Perioperative Medicine, Rutgers Robert Wood Johnson Medical School, 125 Paterson Street, Suite 3100, New Brunswick, NJ 08901-1977, USA.
Liu X; Department of Anesthesiology and Perioperative Medicine, Rutgers Robert Wood Johnson Medical School, 125 Paterson Street, Suite 3100, New Brunswick, NJ 08901-1977, USA.
Patel N; Department of Neuroscience and Cell Biology, Rutgers Robert Wood Johnson Medical School, 675 Hoes Lane West, Piscataway, NJ 08854, USA.
Jacinto E; Department of Biochemistry and Molecular Biology, Rutgers Robert Wood Johnson Medical School, 675 Hoes Lane West, Piscataway, NJ 08854, USA.
Weiss HR; Department of Neuroscience and Cell Biology, Rutgers Robert Wood Johnson Medical School, 675 Hoes Lane West, Piscataway, NJ 08854, USA.
Pokaż więcej
Źródło :
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association [J Stroke Cerebrovasc Dis] 2020 Oct; Vol. 29 (10), pp. 105029. Date of Electronic Publication: 2020 Jul 15.
Typ publikacji :
Journal Article
MeSH Terms :
Reperfusion*
Blood-Brain Barrier/*drug effects
Capillary Permeability/*drug effects
Cerebral Cortex/*drug effects
Infarction, Middle Cerebral Artery/*therapy
Lysophospholipids/*toxicity
Reperfusion Injury/*chemically induced
Animals ; Blood-Brain Barrier/physiopathology ; Cerebral Cortex/enzymology ; Cerebral Cortex/pathology ; Disease Models, Animal ; Infarction, Middle Cerebral Artery/enzymology ; Infarction, Middle Cerebral Artery/pathology ; Infarction, Middle Cerebral Artery/physiopathology ; Male ; Phosphorylation ; Proto-Oncogene Proteins c-akt/metabolism ; Rats, Inbred F344 ; Reperfusion Injury/enzymology ; Reperfusion Injury/pathology ; Reperfusion Injury/physiopathology ; Ribosomal Protein S6 Kinases/metabolism
Czasopismo naukowe

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies