Temat: "brugia malayi" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: Extracellular vesicles secreted by Brugia malayi microfilariae modulate the melanization pathway in the mosquito host.
Autorzy:: Loghry HJ; Department of Biomedical Sciences, College of Veterinary Medicine, Iowa State University, Ames, IA, USA. .
Kwon H; Department of Entomology, College of Agriculture and Life Sciences, Iowa State University, Ames, IA, USA.
Smith RC; Department of Entomology, College of Agriculture and Life Sciences, Iowa State University, Ames, IA, USA.
Sondjaja NA; Department of Biomedical Sciences, College of Veterinary Medicine, Iowa State University, Ames, IA, USA.
Minkler SJ; Department of Biomedical Sciences, College of Veterinary Medicine, Iowa State University, Ames, IA, USA.
Young S; Department of Biomedical Sciences, College of Veterinary Medicine, Iowa State University, Ames, IA, USA.
Wheeler NJ; Department of Biology, College of Arts and Sciences, University of Wisconsin-Eau Claire, Eau Claire, WI, USA.
Zamanian M; Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI, USA.
Bartholomay LC; Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI, USA.
Kimber MJ; Department of Biomedical Sciences, College of Veterinary Medicine, Iowa State University, Ames, IA, USA.; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2023 May 31; Vol. 13 (1), pp. 8778. Date of Electronic Publication: 2023 May 31.
Typ publikacji:: Journal Article
MeSH Terms:: Brugia malayi*/genetics
Aedes*
Extracellular Vesicles*
Animals ; Humans ; Female ; Microfilariae/genetics ; Mosquito Vectors ; Mammals

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Skocz do pozycji: 2.

Tytuł:: Defining the filarial N-glycoproteome by glycosite mapping in the human parasitic nematode Brugia malayi.
Autorzy:: Mersha FB; New England Biolabs, Ipswich, MA, 01938, USA. .
McClung CM; New England Biolabs, Ipswich, MA, 01938, USA.
Chen M; New England Biolabs, Ipswich, MA, 01938, USA.
Ruse CI; New England Biolabs, Ipswich, MA, 01938, USA.
Foster JM; New England Biolabs, Ipswich, MA, 01938, USA. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2023 May 16; Vol. 13 (1), pp. 7951. Date of Electronic Publication: 2023 May 16.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Brugia malayi*/genetics
Animals ; Humans ; Male ; Female ; Chromatography, Liquid ; Tandem Mass Spectrometry ; Peptides/metabolism ; Microfilariae/genetics ; Microfilariae/metabolism ; Glycoproteins/genetics ; Glycoproteins/metabolism ; Proteome/metabolism

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Skocz do pozycji: 3.

Tytuł:: Wbm0076, a candidate effector protein of the Wolbachia endosymbiont of Brugia malayi, disrupts eukaryotic actin dynamics.
Autorzy:: Mills MK; Department of Microbiology, University of Georgia, Athens, Georgia, United States of America.
McCabe LG; Department of Microbiology, University of Georgia, Athens, Georgia, United States of America.
Rodrigue EM; Department of Microbiology, University of Georgia, Athens, Georgia, United States of America.
Lechtreck KF; Department of Cellular Biology, University of Georgia, Athens, Georgia, United States of America.
Starai VJ; Department of Microbiology, University of Georgia, Athens, Georgia, United States of America.; Department of Infectious Diseases, University of Georgia, Athens, Georgia, United States of America.; Pokaż więcej
Źródło:: PLoS pathogens [PLoS Pathog] 2023 Feb 17; Vol. 19 (2), pp. e1010777. Date of Electronic Publication: 2023 Feb 17 (Print Publication: 2023).
Typ publikacji:: Journal Article
MeSH Terms:: Brugia malayi*/genetics
Wolbachia*/physiology
Animals ; Humans ; Actins/metabolism ; Eukaryotic Cells ; Saccharomyces cerevisiae/genetics ; Symbiosis/genetics ; Bacterial Proteins

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Skocz do pozycji: 4.

Tytuł:: Diethylcarbamazine, TRP channels and Ca signaling in cells of the Ascaris intestine.
Autorzy:: Williams PDE; Department of Biomedical Sciences, Iowa State University, Ames, IA, USA.
Kashyap SS; Department of Biomedical Sciences, Iowa State University, Ames, IA, USA.
McHugh MA; Department of Biomedical Sciences, Iowa State University, Ames, IA, USA.
Brewer MT; Department of Veterinary Pathology, Iowa State University, Ames, IA, USA.
Robertson AP; Department of Biomedical Sciences, Iowa State University, Ames, IA, USA.
Martin RJ; Department of Biomedical Sciences, Iowa State University, Ames, IA, USA. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2022 Dec 09; Vol. 12 (1), pp. 21317. Date of Electronic Publication: 2022 Dec 09.
Typ publikacji:: Journal Article
MeSH Terms:: Ascaris suum*
Anthelmintics*/pharmacology
Elephantiasis, Filarial*/drug therapy
Brugia malayi*
Animals ; Ascaris

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Skocz do pozycji: 5.

Tytuł:: Reconstitution of an N-AChR from Brugia malayi, an evolved change in acetylcholine receptor accessory protein requirements in filarial parasites.
Autorzy:: Noonan JD; Institute of Parasitology, McGill University, Ste-Anne-de-Bellevue, Québec, Canada.
Beech RN; Institute of Parasitology, McGill University, Ste-Anne-de-Bellevue, Québec, Canada.; Pokaż więcej
Źródło:: PLoS pathogens [PLoS Pathog] 2022 Nov 14; Vol. 18 (11), pp. e1010962. Date of Electronic Publication: 2022 Nov 14 (Print Publication: 2022).
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Brugia malayi*/metabolism
Parasites*/metabolism
Receptors, Nicotinic*/genetics
Receptors, Nicotinic*/metabolism
Animals ; Acetylcholine/metabolism ; Nicotine/metabolism ; Phylogeny ; Receptors, Cholinergic/genetics ; Receptors, Cholinergic/metabolism

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Skocz do pozycji: 6.

Tytuł:: Alteration of rhesus macaque serum N-glycome during infection with the human parasitic filarial nematode Brugia malayi.
Autorzy:: Petralia LMC; Division of Protein Expression and Modification, New England Biolabs, Ipswich, MA, 01938, USA. .; Department of Parasitology, Center of Infectious Diseases, Leiden University Medical Center, 2333 ZA, Leiden, The Netherlands. .
Santha E; Division of Protein Expression and Modification, New England Biolabs, Ipswich, MA, 01938, USA.
Behrens AJ; Division of Protein Expression and Modification, New England Biolabs, Ipswich, MA, 01938, USA.
Nguyen DL; Department of Parasitology, Center of Infectious Diseases, Leiden University Medical Center, 2333 ZA, Leiden, The Netherlands.
Ganatra MB; Division of Protein Expression and Modification, New England Biolabs, Ipswich, MA, 01938, USA.
Taron CH; Division of Protein Expression and Modification, New England Biolabs, Ipswich, MA, 01938, USA.
Khatri V; Department of Biomedical Sciences, University of Illinois College of Medicine at Rockford, Rockford, IL, USA.
Kalyanasundaram R; Department of Biomedical Sciences, University of Illinois College of Medicine at Rockford, Rockford, IL, USA.
van Diepen A; Department of Parasitology, Center of Infectious Diseases, Leiden University Medical Center, 2333 ZA, Leiden, The Netherlands.
Hokke CH; Department of Parasitology, Center of Infectious Diseases, Leiden University Medical Center, 2333 ZA, Leiden, The Netherlands.
Foster JM; Division of Protein Expression and Modification, New England Biolabs, Ipswich, MA, 01938, USA. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2022 Sep 21; Vol. 12 (1), pp. 15763. Date of Electronic Publication: 2022 Sep 21.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:: Brugia malayi*
Dirofilaria immitis*/physiology
Elephantiasis, Filarial*/parasitology
Animals ; Biomarkers ; Dogs ; Glycoside Hydrolases ; Humans ; Immunoglobulin G ; Macaca mulatta ; Mammals ; Polysaccharides

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Skocz do pozycji: 7.

Tytuł:: A mouse infection model and long-term lymphatic endothelium co-culture system to evaluate drugs against adult Brugia malayi.
Autorzy:: Marriott AE; Centre for Drugs and Diagnostics & Centre for Neglected Tropical Diseases, Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, United Kingdom.
Furlong Silva J; Centre for Drugs and Diagnostics & Centre for Neglected Tropical Diseases, Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, United Kingdom.
Pionnier N; Centre for Drugs and Diagnostics & Centre for Neglected Tropical Diseases, Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, United Kingdom.
Sjoberg H; Centre for Drugs and Diagnostics & Centre for Neglected Tropical Diseases, Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, United Kingdom.
Archer J; Centre for Drugs and Diagnostics & Centre for Neglected Tropical Diseases, Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, United Kingdom.
Steven A; Centre for Drugs and Diagnostics & Centre for Neglected Tropical Diseases, Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, United Kingdom.
Kempf D; Pharmaceutical R&D, AbbVie, North Chicago, Illinois, United States of America.
Taylor MJ; Centre for Drugs and Diagnostics & Centre for Neglected Tropical Diseases, Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, United Kingdom.
Turner JD; Centre for Drugs and Diagnostics & Centre for Neglected Tropical Diseases, Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, United Kingdom.; Pokaż więcej
Źródło:: PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2022 Jun 07; Vol. 16 (6), pp. e0010474. Date of Electronic Publication: 2022 Jun 07 (Print Publication: 2022).
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Brugia malayi*
Wolbachia*
Animals ; Coculture Techniques ; Disease Models, Animal ; Endothelial Cells ; Endothelium, Lymphatic ; Female ; Interleukin-5 ; Male ; Mice ; Mice, Inbred BALB C

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Skocz do pozycji: 8.

Tytuł:: Spatial transcriptomics reveals antiparasitic targets associated with essential behaviors in the human parasite Brugia malayi.
Autorzy:: Airs PM; Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.
Vaccaro K; Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.
Gallo KJ; Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.
Dinguirard N; Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.
Heimark ZW; Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.
Wheeler NJ; Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.
He J; Morgridge Institute for Research, Madison, Wisconsin, United States of America.
Weiss KR; Morgridge Institute for Research, Madison, Wisconsin, United States of America.
Schroeder NE; Neuroscience Program, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America.; Department of Crop Sciences, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America.
Huisken J; Morgridge Institute for Research, Madison, Wisconsin, United States of America.; Department of Integrative Biology, University of Wisconsin, Madison, Wisconsin, United States of America.
Zamanian M; Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.; Pokaż więcej
Źródło:: PLoS pathogens [PLoS Pathog] 2022 Apr 07; Vol. 18 (4), pp. e1010399. Date of Electronic Publication: 2022 Apr 07 (Print Publication: 2022).
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:: Anti-Infective Agents*/pharmacology
Brugia malayi*/genetics
Elephantiasis, Filarial*
Parasites*/genetics
Vaccines*
Animals ; Antiparasitic Agents/pharmacology ; Humans ; Transcriptome

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Skocz do pozycji: 9.

Tytuł:: A novel series of putative Brugia malayi histone demethylase inhibitors as potential anti-filarial drugs.
Autorzy:: Kreiss T; Montclair State University and the Sokol Institute of Pharmaceutical Life Sciences, Montclair, New Jersey, United States of America.; Department of Microbiology, Biochemistry and Molecular Genetics. New Jersey Medical School, Newark, New Jersey, United States of America.
Eck T; Montclair State University and the Sokol Institute of Pharmaceutical Life Sciences, Montclair, New Jersey, United States of America.; Department of Microbiology, Biochemistry and Molecular Genetics. New Jersey Medical School, Newark, New Jersey, United States of America.
Hart B; Montclair State University and the Sokol Institute of Pharmaceutical Life Sciences, Montclair, New Jersey, United States of America.
Tummalapalli S; Montclair State University and the Sokol Institute of Pharmaceutical Life Sciences, Montclair, New Jersey, United States of America.
Rotella D; Montclair State University and the Sokol Institute of Pharmaceutical Life Sciences, Montclair, New Jersey, United States of America.
Siekierka J; Montclair State University and the Sokol Institute of Pharmaceutical Life Sciences, Montclair, New Jersey, United States of America.; Pokaż więcej
Źródło:: PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2022 Mar 16; Vol. 16 (3), pp. e0010216. Date of Electronic Publication: 2022 Mar 16 (Print Publication: 2022).
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Brugia malayi*
Adult ; Animals ; Histone Demethylases ; Histones ; Humans ; Loa ; Microfilariae ; Pharmaceutical Preparations

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Skocz do pozycji: 10.

Tytuł:: Molecular Characterization of a Reemergent Brugia malayi Parasite in Sri Lanka, Suggestive of a Novel Strain.
Autorzy:: Mallawarachchi CH; Medical Research Institute, Colombo, Sri Lanka.
Chandrasena TGAN; Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka.
Withanage GP; Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka.
Premarathna R; Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka.
Mallawarachchi SMNSM; Ministry of Health and Indigenous Medicine, Colombo, Sri Lanka.
Gunawardane NY; Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka.
Dasanayake RS; University of Colombo, Colombo, Sri Lanka.
Gunarathna D; Ministry of Plantation Industries, Battaramulla, Colombo, Sri Lanka.
de Silva NR; Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka.; Pokaż więcej
Źródło:: BioMed research international [Biomed Res Int] 2021 Aug 07; Vol. 2021, pp. 9926101. Date of Electronic Publication: 2021 Aug 07 (Print Publication: 2021).
Typ publikacji:: Journal Article
MeSH Terms:: Brugia malayi/*classification
DNA, Ribosomal Spacer/*genetics
Elephantiasis, Filarial/*parasitology
Sequence Analysis, DNA/*methods
Animals ; Blood/parasitology ; Brugia malayi/genetics ; Brugia malayi/isolation & purification ; Cats ; Culicidae/parasitology ; DNA, Protozoan/genetics ; Dogs ; Elephantiasis, Filarial/veterinary ; Genetic Variation ; Humans ; Phylogeny ; Population Surveillance ; Sri Lanka

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Skocz do pozycji: 11.

Tytuł:: The Eagle effect in the Wolbachia-worm symbiosis.
Autorzy:: Bulman CA; Department of Pharmaceutical Chemistry, University of California, San Francisco, CA, USA.
Chappell L; Department of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, CA, USA.
Gunderson E; Department of Pharmaceutical Chemistry, University of California, San Francisco, CA, USA.
Vogel I; Department of Pharmaceutical Chemistry, University of California, San Francisco, CA, USA.
Beerntsen B; Veterinary Pathobiology, University of Missouri-Columbia, Columbia, MO, USA.
Slatko BE; Molecular Parasitology Division, New England Biolabs Inc, Ipswich, MA, USA.
Sullivan W; Department of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, CA, USA.
Sakanari JA; Department of Pharmaceutical Chemistry, University of California, San Francisco, CA, USA. .; Pokaż więcej
Źródło:: Parasites & vectors [Parasit Vectors] 2021 Feb 24; Vol. 14 (1), pp. 118. Date of Electronic Publication: 2021 Feb 24.
Typ publikacji:: Journal Article
MeSH Terms:: Symbiosis*/drug effects
Brugia malayi/*physiology
Microfilariae/*microbiology
Onchocerca/*physiology
Wolbachia/*physiology
Animals ; Anti-Bacterial Agents/pharmacology ; Brugia malayi/drug effects ; Brugia malayi/microbiology ; Doxycycline/pharmacology ; Female ; Male ; Microfilariae/drug effects ; Microfilariae/physiology ; Onchocerca/drug effects ; Onchocerca/microbiology ; Wolbachia/drug effects

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Skocz do pozycji: 12.

Tytuł:: A novel assay to isolate and quantify third-stage Dirofilaria immitis and Brugia malayi larvae emerging from individual Aedes aegypti.
Autorzy:: McCrea AR; Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Edgerton EB; Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Oliver GT; Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
O'Neill FM; Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Nolan TJ; Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Lok JB; Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Povelones M; Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA. .; Pokaż więcej
Źródło:: Parasites & vectors [Parasit Vectors] 2021 Jan 07; Vol. 14 (1), pp. 30. Date of Electronic Publication: 2021 Jan 07.
Typ publikacji:: Journal Article
MeSH Terms:: Aedes/*parasitology
Biological Assay/*methods
Brugia malayi/*physiology
Dirofilaria immitis/*physiology
Larva/*physiology
Mosquito Vectors/*parasitology
Animals ; Brugia malayi/isolation & purification ; Dirofilaria immitis/isolation & purification ; Dirofilariasis/parasitology ; Dirofilariasis/transmission ; Microfilariae/physiology

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Skocz do pozycji: 13.

Tytuł:: Ivermectin inhibits extracellular vesicle secretion from parasitic nematodes.
Autorzy:: Loghry HJ; Department of Biomedical Sciences College of Veterinary Medicine Iowa State University Ames Iowa USA.
Yuan W; Department of Biomedical Sciences College of Veterinary Medicine Iowa State University Ames Iowa USA.
Zamanian M; Department of Pathobiological Sciences University of Wisconsin-Madison Madison Wisconsin USA.
Wheeler NJ; Department of Pathobiological Sciences University of Wisconsin-Madison Madison Wisconsin USA.
Day TA; Department of Biomedical Sciences College of Veterinary Medicine Iowa State University Ames Iowa USA.
Kimber MJ; Department of Biomedical Sciences College of Veterinary Medicine Iowa State University Ames Iowa USA.; Pokaż więcej
Źródło:: Journal of extracellular vesicles [J Extracell Vesicles] 2020 Dec; Vol. 10 (2), pp. e12036. Date of Electronic Publication: 2020 Dec 10.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:: Brugia malayi/*drug effects
Elephantiasis, Filarial/*drug therapy
Extracellular Vesicles/*metabolism
Gastrointestinal Tract/*drug effects
Helminth Proteins/*metabolism
Ivermectin/*pharmacology
Microfilariae/*drug effects
Animals ; Antiparasitic Agents/pharmacology ; Brugia malayi/physiology ; Elephantiasis, Filarial/metabolism ; Elephantiasis, Filarial/parasitology ; Extracellular Vesicles/drug effects ; Female ; Gastrointestinal Tract/metabolism ; Gastrointestinal Tract/parasitology ; Locomotion ; Male ; Microfilariae/parasitology ; Phagocytosis

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Skocz do pozycji: 14.

Tytuł:: Extracellular vesicles released from the filarial parasite Brugia malayi downregulate the host mTOR pathway.
Autorzy:: Ricciardi A; Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, United States of America.
Bennuru S; Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, United States of America.
Tariq S; Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, United States of America.
Kaur S; Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland, United States of America.
Wu W; Microarray Core, Cancer Genetics and Comparative Genomics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland, United States of America.
Elkahloun AG; Microarray Core, Cancer Genetics and Comparative Genomics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland, United States of America.
Arakelyan A; Section of Intracellular Interactions, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, Maryland, United States of America.
Shaik J; Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, United States of America.
Dorward DW; RML Microscopy Unit, RML Research Technologies Section, National Institute of Allergy and Infectious Diseases, NIH, Hamilton, Montana, United States of America.
Nutman TB; Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, United States of America.
Tolouei Semnani R; Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, United States of America.; Pokaż więcej
Źródło:: PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2021 Jan 07; Vol. 15 (1), pp. e0008884. Date of Electronic Publication: 2021 Jan 07 (Print Publication: 2021).
Typ publikacji:: Journal Article; Research Support, N.I.H., Intramural
MeSH Terms:: Down-Regulation*
Brugia malayi/*metabolism
Extracellular Vesicles/*metabolism
TOR Serine-Threonine Kinases/*metabolism
Adaptor Proteins, Signal Transducing/metabolism ; Animals ; Brugia malayi/immunology ; Cell Cycle Proteins/metabolism ; Dendritic Cells/immunology ; Filariasis/immunology ; Humans ; MicroRNAs/metabolism ; Microfilariae/immunology ; Monocytes/metabolism ; Phosphorylation ; Proteomics ; THP-1 Cells ; TOR Serine-Threonine Kinases/genetics

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Skocz do pozycji: 15.

Tytuł:: Structural features and development of an assay platform of the parasite target deoxyhypusine synthase of Brugia malayi and Leishmania major.
Autorzy:: Silva SF; Chemistry Institute, São Paulo State University-UNESP, Araraquara, SP, Brazil.
Klippel AH; School of Pharmaceutical Sciences, São Paulo State University-UNESP, Araraquara, SP, Brazil.
Ramos PZ; Molecular Biology and Genetic Engineering Center (CBMEG), Medicinal Chemistry Center (CQMED), Structural Genomics Consortium (SGC-UNICAMP), University of Campinas-UNICAMP, Campinas, SP, Brazil.; Department of Structural and Functional Biology, Institute of Biology, University of Campinas-UNICAMP, Campinas, SP, Brazil.
Santiago ADS; Molecular Biology and Genetic Engineering Center (CBMEG), Medicinal Chemistry Center (CQMED), Structural Genomics Consortium (SGC-UNICAMP), University of Campinas-UNICAMP, Campinas, SP, Brazil.; Department of Structural and Functional Biology, Institute of Biology, University of Campinas-UNICAMP, Campinas, SP, Brazil.
Valentini SR; School of Pharmaceutical Sciences, São Paulo State University-UNESP, Araraquara, SP, Brazil.
Bengtson MH; Molecular Biology and Genetic Engineering Center (CBMEG), Medicinal Chemistry Center (CQMED), Structural Genomics Consortium (SGC-UNICAMP), University of Campinas-UNICAMP, Campinas, SP, Brazil.; Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas-UNICAMP, Campinas, SP, Brazil.
Massirer KB; Molecular Biology and Genetic Engineering Center (CBMEG), Medicinal Chemistry Center (CQMED), Structural Genomics Consortium (SGC-UNICAMP), University of Campinas-UNICAMP, Campinas, SP, Brazil.; Department of Structural and Functional Biology, Institute of Biology, University of Campinas-UNICAMP, Campinas, SP, Brazil.
Bilsland E; Department of Structural and Functional Biology, Institute of Biology, University of Campinas-UNICAMP, Campinas, SP, Brazil.
Couñago RM; Molecular Biology and Genetic Engineering Center (CBMEG), Medicinal Chemistry Center (CQMED), Structural Genomics Consortium (SGC-UNICAMP), University of Campinas-UNICAMP, Campinas, SP, Brazil.
Zanelli CF; School of Pharmaceutical Sciences, São Paulo State University-UNESP, Araraquara, SP, Brazil.; Pokaż więcej
Źródło:: PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2020 Oct 12; Vol. 14 (10), pp. e0008762. Date of Electronic Publication: 2020 Oct 12 (Print Publication: 2020).
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Anthelmintics/*pharmacology
Antiprotozoal Agents/*pharmacology
Brugia malayi/*drug effects
Enzyme Inhibitors/*pharmacology
Helminth Proteins/*antagonists & inhibitors
Leishmania major/*drug effects
Oxidoreductases Acting on CH-NH Group Donors/*antagonists & inhibitors
Protozoan Proteins/*antagonists & inhibitors
Amino Acid Sequence ; Animals ; Anthelmintics/chemistry ; Antiprotozoal Agents/chemistry ; Brugia malayi/enzymology ; Brugia malayi/genetics ; Brugia malayi/growth & development ; Drug Evaluation, Preclinical ; Enzyme Inhibitors/chemistry ; Helminth Proteins/chemistry ; Helminth Proteins/genetics ; Helminth Proteins/metabolism ; High-Throughput Screening Assays ; Leishmania major/enzymology ; Leishmania major/genetics ; Leishmania major/growth & development ; Oxidoreductases Acting on CH-NH Group Donors/chemistry ; Oxidoreductases Acting on CH-NH Group Donors/genetics ; Oxidoreductases Acting on CH-NH Group Donors/metabolism ; Protozoan Proteins/chemistry ; Protozoan Proteins/genetics ; Protozoan Proteins/metabolism ; Sequence Alignment

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Skocz do pozycji: 16.

Tytuł:: Intestinal UDP-glucuronosyltransferase as a potential target for the treatment and prevention of lymphatic filariasis.
Autorzy:: Flynn AF; Department of Microbiology, F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America.
Joyce MG; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, Maryland, United States of America.
Taylor RT; Department of Biology, Frostburg State University, Frostburg, Maryland, United States of America.
Bennuru S; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America.
Lindrose AR; Department of Microbiology, F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America.
Sterling SL; Department of Microbiology, F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America.
Morris CP; Department of Pathology, Johns Hopkins Hospital, Baltimore Maryland, United States of America.
Nutman TB; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America.
Mitre E; Department of Microbiology, F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America.; Pokaż więcej
Źródło:: PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2019 Sep 12; Vol. 13 (9), pp. e0007687. Date of Electronic Publication: 2019 Sep 12 (Print Publication: 2019).
Typ publikacji:: Journal Article; Research Support, N.I.H., Intramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:: Brugia malayi/*drug effects
Brugia malayi/*enzymology
Glucuronosyltransferase/*metabolism
Albendazole/pharmacology ; Animals ; Antigens, Helminth/blood ; Brugia malayi/immunology ; Brugia malayi/metabolism ; Drug Therapy, Combination ; Elephantiasis, Filarial/drug therapy ; Elephantiasis, Filarial/prevention & control ; Female ; Filaricides/pharmacology ; Glucuronosyltransferase/antagonists & inhibitors ; Glucuronosyltransferase/genetics ; Humans ; Immunoglobulin E/blood ; Intestines/enzymology ; Microfilariae/drug effects ; Movement ; Probenecid/pharmacology ; RNA, Small Interfering ; Sulfinpyrazone/pharmacology

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Skocz do pozycji: 17.

Tytuł:: Diethylcarbamazine activates TRP channels including TRP-2 in filaria, Brugia malayi.
Autorzy:: Verma S; Department of Biomedical Sciences, Iowa State University, Ames, IA, 50011, USA.
Kashyap SS; Department of Biomedical Sciences, Iowa State University, Ames, IA, 50011, USA.
Robertson AP; Department of Biomedical Sciences, Iowa State University, Ames, IA, 50011, USA.
Martin RJ; Department of Biomedical Sciences, Iowa State University, Ames, IA, 50011, USA. .; Pokaż więcej
Źródło:: Communications biology [Commun Biol] 2020 Jul 28; Vol. 3 (1), pp. 398. Date of Electronic Publication: 2020 Jul 28.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:: Brugia malayi/*genetics
Diethylcarbamazine/*pharmacology
Filariasis/*drug therapy
Intramolecular Oxidoreductases/*genetics
Animals ; Brugia malayi/pathogenicity ; Filariasis/genetics ; Filariasis/parasitology ; Filariasis/pathology ; Humans ; Transient Receptor Potential Channels/genetics

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Skocz do pozycji: 18.

Tytuł:: Prediction pipeline for discovery of regulatory motifs associated with Brugia malayi molting.
Autorzy:: Grote A; Department of Biology, Center for Genomics and Systems Biology, New York University, New York, New York, United States of America.
Li Y; School of Computer Science and Electrical Engineering, Ohio University, Athens, Ohio, United States of America.
Liu C; Center for Global Infectious Disease Research, University of South Florida, Tampa, FL, Florida, United States of America.
Voronin D; Laboratory of Molecular Parasitology, Lindsley F. Kimball Research Institute, New York Blood Center, New York, New York, United States of America.
Geber A; Department of Biology, Center for Genomics and Systems Biology, New York University, New York, New York, United States of America.
Lustigman S; Laboratory of Molecular Parasitology, Lindsley F. Kimball Research Institute, New York Blood Center, New York, New York, United States of America.
Unnasch TR; Center for Global Infectious Disease Research, University of South Florida, Tampa, FL, Florida, United States of America.
Welch L; School of Computer Science and Electrical Engineering, Ohio University, Athens, Ohio, United States of America.
Ghedin E; Department of Biology, Center for Genomics and Systems Biology, New York University, New York, New York, United States of America.; Department of Epidemiology, School of Global Public Health, New York University, New York, New York, United States of America.; Pokaż więcej
Źródło:: PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2020 Jun 23; Vol. 14 (6), pp. e0008275. Date of Electronic Publication: 2020 Jun 23 (Print Publication: 2020).
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:: Genes, Helminth*
Molting*
Brugia malayi/*genetics
Transcription Factors/*genetics
Animals ; Base Sequence ; Brugia malayi/physiology ; Caenorhabditis elegans/genetics ; Caenorhabditis elegans/physiology ; Gene Expression Profiling ; Larva ; Oligonucleotide Array Sequence Analysis ; Onchocerca volvulus/genetics ; Onchocerca volvulus/physiology ; RNA, Helminth/genetics

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Skocz do pozycji: 19.

Tytuł:: Wandering intravitreal worm of Brugia malayi from Central India.
Autorzy:: Sharma G; Vitreoretina & Uvea & Comprehensive Services, ASG Eye Care, Guwahati, Assam, India.
Agrawal D; Cornea, Cataract & Anterior Segment Services, MGM Eye Institute, Raipur, Chattishgarh, India.; Pokaż więcej
Źródło:: Indian journal of ophthalmology [Indian J Ophthalmol] 2020 Jun; Vol. 68 (6), pp. 1166-1167.
Typ publikacji:: Journal Article
MeSH Terms:: Brugia malayi*
Animals ; India/epidemiology

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Skocz do pozycji: 20.

Tytuł:: Emodepside has sex-dependent immobilizing effects on adult Brugia malayi due to a differentially spliced binding pocket in the RCK1 region of the SLO-1 K channel.
Autorzy:: Kashyap SS; Department of Biomedical Sciences, Iowa State University, Ames, Iowa, United States of America.
Verma S; Department of Biomedical Sciences, Iowa State University, Ames, Iowa, United States of America.
Voronin D; Laboratory of Molecular Parasitology, Lindsley F. Kimball Research Institute, New York Blood Center, New York, New York, United States of America.
Lustigman S; Laboratory of Molecular Parasitology, Lindsley F. Kimball Research Institute, New York Blood Center, New York, New York, United States of America.
Kulke D; Bayer Animal Health GmbH, Drug Discovery and External Innovation, Leverkusen, Germany.
Robertson AP; Department of Biomedical Sciences, Iowa State University, Ames, Iowa, United States of America.
Martin RJ; Department of Biomedical Sciences, Iowa State University, Ames, Iowa, United States of America.; Pokaż więcej
Źródło:: PLoS pathogens [PLoS Pathog] 2019 Sep 25; Vol. 15 (9), pp. e1008041. Date of Electronic Publication: 2019 Sep 25 (Print Publication: 2019).
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:: Brugia malayi/*drug effects
Brugia malayi/*physiology
Depsipeptides/*pharmacology
Filaricides/*pharmacology
Large-Conductance Calcium-Activated Potassium Channels/*metabolism
Alternative Splicing ; Amino Acid Sequence ; Animals ; Binding Sites/genetics ; Brugia malayi/genetics ; Female ; Filariasis/drug therapy ; Filariasis/parasitology ; Gene Knockdown Techniques ; Humans ; Large-Conductance Calcium-Activated Potassium Channels/chemistry ; Large-Conductance Calcium-Activated Potassium Channels/genetics ; Male ; Models, Molecular ; Movement/drug effects ; Movement/physiology ; Muscles/drug effects ; Muscles/physiology ; Peptides/pharmacology ; Potassium Channel Blockers/pharmacology ; Sequence Homology, Amino Acid ; Sex Factors

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