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Wyszukujesz frazę ""c-KIT"" wg kryterium: Temat


Tytuł :
RUNX1/ETO and mutant KIT both contribute to programming the transcriptional and chromatin landscape in t(8;21) acute myeloid leukemia.
Autorzy :
Chin PS; Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.
Assi SA; Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.
Ptasinska A; Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.
Imperato MR; Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.
Cockerill PN; Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.
Bonifer C; Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK. Electronic address: c..
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Źródło :
Experimental hematology [Exp Hematol] 2020 Dec; Vol. 92, pp. 62-74. Date of Electronic Publication: 2020 Nov 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Chromosomes, Human, Pair 21*/genetics
Chromosomes, Human, Pair 21*/metabolism
Chromosomes, Human, Pair 8*/genetics
Chromosomes, Human, Pair 8*/metabolism
Leukemia, Myeloid, Acute*/genetics
Leukemia, Myeloid, Acute*/metabolism
Leukemia, Myeloid, Acute*/pathology
Mutation, Missense*
Transcription, Genetic*
Translocation, Genetic*
Chromatin/*metabolism
Core Binding Factor Alpha 2 Subunit/*metabolism
Proto-Oncogene Proteins c-kit/*metabolism
RUNX1 Translocation Partner 1 Protein/*metabolism
Amino Acid Substitution ; Chromatin/pathology ; Core Binding Factor Alpha 2 Subunit/genetics ; Female ; Gene Expression Regulation, Leukemic ; HEK293 Cells ; Humans ; Male ; Proto-Oncogene Proteins c-kit/genetics ; RUNX1 Translocation Partner 1 Protein/genetics
Czasopismo naukowe
Tytuł :
Catching the clinical and biological diversity for an appropriate therapeutic approach in systemic mastocytosis.
Autorzy :
Mannelli F; CRIMM, Centro di Ricerca e Innovazione per le Malattie Mieloproliferative, SOD Ematologia, Azienda Ospedaliera Universitaria Careggi, Largo Brambilla 3, 50134, Firenze, Italy. .
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Źródło :
Annals of hematology [Ann Hematol] 2021 Feb; Vol. 100 (2), pp. 337-344. Date of Electronic Publication: 2020 Nov 06.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Cladribine/*therapeutic use
Interferons/*therapeutic use
Mastocytosis, Systemic/*drug therapy
Proto-Oncogene Proteins c-kit/*antagonists & inhibitors
Humans ; Mast Cells/metabolism ; Mast Cells/pathology ; Mastocytosis, Systemic/metabolism ; Mastocytosis, Systemic/pathology ; Proto-Oncogene Proteins c-kit/metabolism
Czasopismo naukowe
Tytuł :
Anti-human CD117 CAR T-cells efficiently eliminate healthy and malignant CD117-expressing hematopoietic cells.
Autorzy :
Myburgh R; Department of Medical Oncology and Hematology, University Hospital Zurich and University of Zurich, Comprehensive Cancer Center Zurich (CCCZ), Zurich, Switzerland.
Kiefer JD; Department of Medical Oncology and Hematology, University Hospital Zurich and University of Zurich, Comprehensive Cancer Center Zurich (CCCZ), Zurich, Switzerland.; Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, ETH Zurich, Comprehensive Cancer Center Zurich (CCCZ), Zurich, Switzerland.
Russkamp NF; Department of Medical Oncology and Hematology, University Hospital Zurich and University of Zurich, Comprehensive Cancer Center Zurich (CCCZ), Zurich, Switzerland.
Magnani CF; Department of Medical Oncology and Hematology, University Hospital Zurich and University of Zurich, Comprehensive Cancer Center Zurich (CCCZ), Zurich, Switzerland.
Nuñez N; Institute of Experimental Immunology, University of Zurich, Comprehensive Cancer Center Zurich (CCCZ), Zurich, Switzerland.
Simonis A; Department of Medical Oncology and Hematology, University Hospital Zurich and University of Zurich, Comprehensive Cancer Center Zurich (CCCZ), Zurich, Switzerland.
Pfister S; Department of Medical Oncology and Hematology, University Hospital Zurich and University of Zurich, Comprehensive Cancer Center Zurich (CCCZ), Zurich, Switzerland.
Wilk CM; Department of Medical Oncology and Hematology, University Hospital Zurich and University of Zurich, Comprehensive Cancer Center Zurich (CCCZ), Zurich, Switzerland.
McHugh D; Institute of Experimental Immunology, University of Zurich, Comprehensive Cancer Center Zurich (CCCZ), Zurich, Switzerland.
Friemel J; Institute of Pathology and Molecular Pathology, University and University Hospital Zurich, Comprehensive Cancer Center Zurich (CCCZ), Zurich, Switzerland.
Müller AM; Department of Medical Oncology and Hematology, University Hospital Zurich and University of Zurich, Comprehensive Cancer Center Zurich (CCCZ), Zurich, Switzerland.
Becher B; Institute of Experimental Immunology, University of Zurich, Comprehensive Cancer Center Zurich (CCCZ), Zurich, Switzerland.
Münz C; Institute of Experimental Immunology, University of Zurich, Comprehensive Cancer Center Zurich (CCCZ), Zurich, Switzerland.
van den Broek M; Institute of Experimental Immunology, University of Zurich, Comprehensive Cancer Center Zurich (CCCZ), Zurich, Switzerland.
Neri D; Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, ETH Zurich, Comprehensive Cancer Center Zurich (CCCZ), Zurich, Switzerland.
Manz MG; Department of Medical Oncology and Hematology, University Hospital Zurich and University of Zurich, Comprehensive Cancer Center Zurich (CCCZ), Zurich, Switzerland. .
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Źródło :
Leukemia [Leukemia] 2020 Oct; Vol. 34 (10), pp. 2688-2703. Date of Electronic Publication: 2020 May 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Immunotherapy, Adoptive*
Proto-Oncogene Proteins c-kit/*antagonists & inhibitors
Receptors, Antigen, T-Cell/*immunology
Receptors, Chimeric Antigen/*immunology
T-Lymphocytes/*immunology
T-Lymphocytes/*metabolism
Animals ; Biomarkers ; Biopsy ; Bone Marrow/metabolism ; Bone Marrow/pathology ; Cell Line, Tumor ; Disease Models, Animal ; Gene Expression ; Hematologic Neoplasms/diagnosis ; Hematologic Neoplasms/immunology ; Hematologic Neoplasms/metabolism ; Hematologic Neoplasms/therapy ; Hematopoietic Stem Cells/immunology ; Hematopoietic Stem Cells/metabolism ; Humans ; Immunophenotyping ; Leukemia, Myeloid, Acute/genetics ; Leukemia, Myeloid, Acute/immunology ; Leukemia, Myeloid, Acute/pathology ; Leukemia, Myeloid, Acute/therapy ; Lymphocyte Depletion ; Mice ; Proto-Oncogene Proteins c-kit/genetics ; Proto-Oncogene Proteins c-kit/metabolism ; Receptors, Antigen, T-Cell/genetics ; Receptors, Chimeric Antigen/genetics ; Treatment Outcome ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Evidence supports white spotting in donkeys as a homozygous lethal condition.
Autorzy :
Tanaka J; Veterinary Genetics Laboratory, School of Veterinary Medicine, University of California, Davis, CA, 95616, USA.
Grahn R; Veterinary Genetics Laboratory, School of Veterinary Medicine, University of California, Davis, CA, 95616, USA.
Bellone RR; Veterinary Genetics Laboratory, School of Veterinary Medicine, University of California, Davis, CA, 95616, USA.; Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, CA, 95616, USA.
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Źródło :
Animal genetics [Anim Genet] 2020 Oct; Vol. 51 (5), pp. 840-842. Date of Electronic Publication: 2020 Jul 13.
Typ publikacji :
Journal Article
MeSH Terms :
Equidae/*physiology
Genes, Lethal/*genetics
Hair Color/*genetics
Proto-Oncogene Proteins c-kit/*genetics
Animals ; Equidae/genetics ; Genes, Recessive/genetics ; Homozygote ; Mutation ; Proto-Oncogene Proteins c-kit/metabolism
Czasopismo naukowe
Tytuł :
Pressure overload by suprarenal aortic constriction in mice leads to left ventricular hypertrophy without c-Kit expression in cardiomyocytes.
Autorzy :
Nicks AM; Division of Molecular Cardiology and Biophysics, Victor Chang Cardiac Research Institute, 405 Liverpool Street, Darlinghurst, Sydney, NSW, 2010, Australia.; St Vincent's Clinical School, University of New South Wales, Sydney, NSW, 2052, Australia.
Kesteven SH; Division of Molecular Cardiology and Biophysics, Victor Chang Cardiac Research Institute, 405 Liverpool Street, Darlinghurst, Sydney, NSW, 2010, Australia.; St Vincent's Clinical School, University of New South Wales, Sydney, NSW, 2052, Australia.
Li M; Division of Molecular Cardiology and Biophysics, Victor Chang Cardiac Research Institute, 405 Liverpool Street, Darlinghurst, Sydney, NSW, 2010, Australia.; Cardiac Regeneration Research Institute, Wenzhou Medical University, Wenzhou, 325035, China.
Wu J; Division of Molecular Cardiology and Biophysics, Victor Chang Cardiac Research Institute, 405 Liverpool Street, Darlinghurst, Sydney, NSW, 2010, Australia.
Chan AY; Division of Molecular Cardiology and Biophysics, Victor Chang Cardiac Research Institute, 405 Liverpool Street, Darlinghurst, Sydney, NSW, 2010, Australia.
Naqvi N; Department of Medicine, Emory University, Atlanta, GA, 30322, USA.
Husain A; Department of Medicine, Emory University, Atlanta, GA, 30322, USA.
Feneley MP; Division of Molecular Cardiology and Biophysics, Victor Chang Cardiac Research Institute, 405 Liverpool Street, Darlinghurst, Sydney, NSW, 2010, Australia.; St Vincent's Clinical School, University of New South Wales, Sydney, NSW, 2052, Australia.
Smith NJ; Division of Molecular Cardiology and Biophysics, Victor Chang Cardiac Research Institute, 405 Liverpool Street, Darlinghurst, Sydney, NSW, 2010, Australia.; St Vincent's Clinical School, University of New South Wales, Sydney, NSW, 2052, Australia.
Iismaa SE; Division of Molecular Cardiology and Biophysics, Victor Chang Cardiac Research Institute, 405 Liverpool Street, Darlinghurst, Sydney, NSW, 2010, Australia.; St Vincent's Clinical School, University of New South Wales, Sydney, NSW, 2052, Australia.
Graham RM; Division of Molecular Cardiology and Biophysics, Victor Chang Cardiac Research Institute, 405 Liverpool Street, Darlinghurst, Sydney, NSW, 2010, Australia. .; St Vincent's Clinical School, University of New South Wales, Sydney, NSW, 2052, Australia. .
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Źródło :
Scientific reports [Sci Rep] 2020 Sep 18; Vol. 10 (1), pp. 15318. Date of Electronic Publication: 2020 Sep 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Hypertrophy, Left Ventricular/*pathology
Myocytes, Cardiac/*pathology
Proto-Oncogene Proteins c-kit/*metabolism
Animals ; Aorta/physiopathology ; Constriction, Pathologic ; Gene Expression Regulation ; Hypertension/etiology ; Hypertension/physiopathology ; Hypertrophy, Left Ventricular/genetics ; Male ; Mice, Inbred C57BL ; Mice, Transgenic ; Pressure ; Proto-Oncogene Proteins c-kit/genetics ; Renal Circulation ; Renin/genetics ; Ventricular Dysfunction, Left/genetics ; Ventricular Dysfunction, Left/physiopathology ; Ventricular Remodeling/genetics ; Ventricular Remodeling/physiology
Czasopismo naukowe
Tytuł :
KIT and Melanoma: Biological Insights and Clinical Implications.
Autorzy :
Pham DDM; Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, Korea.
Guhan S; Harvard Medical School, Boston, MA, USA.
Tsao H; Harvard Medical School, Boston, MA, USA.; Department of Dermatology, Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. .
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Źródło :
Yonsei medical journal [Yonsei Med J] 2020 Jul; Vol. 61 (7), pp. 562-571.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Antineoplastic Agents/*therapeutic use
Biomarkers, Tumor/*metabolism
Drug Resistance, Neoplasm/*genetics
Melanoma/*drug therapy
Melanoma/*metabolism
Proto-Oncogene Proteins c-kit/*therapeutic use
Signal Transduction/*drug effects
Skin Neoplasms/*drug therapy
Skin Neoplasms/*metabolism
Female ; Humans ; Male ; Melanoma/genetics ; Mucous Membrane/metabolism ; Mutation ; Proto-Oncogene Proteins c-kit/genetics ; Proto-Oncogene Proteins c-kit/metabolism ; Receptor Protein-Tyrosine Kinases/genetics ; Skin Neoplasms/genetics
Czasopismo naukowe
Tytuł :
Sterile α-motif domain requirement for cellular signaling and survival.
Autorzy :
Ray S; Department of Genetics, Cell Biology and Anatomy, Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, Nebraska 68198.
Chee L; Department of Genetics, Cell Biology and Anatomy, Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, Nebraska 68198.
Matson DR; University of Wisconsin-Madison Blood Research Program, Department of Cell and Regenerative Biology, Carbone Cancer Center, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53705.
Palermo NY; Holland Computing Center, University of Nebraska-Lincoln, Lincoln, Nebraska 68588.
Bresnick EH; University of Wisconsin-Madison Blood Research Program, Department of Cell and Regenerative Biology, Carbone Cancer Center, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53705.
Hewitt KJ; Department of Genetics, Cell Biology and Anatomy, Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, Nebraska 68198 .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2020 May 15; Vol. 295 (20), pp. 7113-7125. Date of Electronic Publication: 2020 Apr 02.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Enhancer Elements, Genetic*
Gene Expression Regulation*
Signal Transduction*
Anemia, Hemolytic/*metabolism
Proteins/*metabolism
Proto-Oncogene Proteins c-kit/*metabolism
Amino Acid Motifs ; Anemia, Hemolytic/genetics ; Anemia, Hemolytic/pathology ; Animals ; Mice ; Mice, Mutant Strains ; Protein Domains ; Proteins/genetics ; Proto-Oncogene Proteins c-kit/genetics
Czasopismo naukowe
Tytuł :
c-KIT regulates stability of cancer stemness in CD44-positive colorectal cancer cells.
Autorzy :
Tomizawa F; Division of Molecular Biotherapy, Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Tokyo, Japan; Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan.
Jang MK; Division of Molecular Biotherapy, Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Tokyo, Japan; Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan.
Mashima T; Division of Molecular Biotherapy, Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Tokyo, Japan.
Seimiya H; Division of Molecular Biotherapy, Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Tokyo, Japan; Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan. Electronic address: .
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2020 Jul 05; Vol. 527 (4), pp. 1014-1020. Date of Electronic Publication: 2020 May 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Colorectal Neoplasms/*pathology
Hyaluronan Receptors/*analysis
Neoplastic Stem Cells/*pathology
Proto-Oncogene Proteins c-kit/*analysis
Animals ; Biomarkers, Tumor/analysis ; Biomarkers, Tumor/genetics ; Cell Line, Tumor ; Colorectal Neoplasms/genetics ; Gene Expression Regulation, Neoplastic ; Humans ; Hyaluronan Receptors/genetics ; Mice ; Neoplastic Stem Cells/metabolism ; Proto-Oncogene Proteins c-kit/genetics
Czasopismo naukowe
Tytuł :
Urticaria Pigmentosa.
Autorzy :
Panigrahi A; Department of Dermatology, Venereology, and Leprosy, R. G. Kar Medical College, Kolkata, India.
Chakraborty S; Department of Dermatology, Venereology, and Leprosy, R. G. Kar Medical College, Kolkata, India.
Sil A; Department of Dermatology, Venereology, and Leprosy, R. G. Kar Medical College, Kolkata, India.
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Źródło :
The Journal of pediatrics [J Pediatr] 2020 Jul; Vol. 222, pp. 249. Date of Electronic Publication: 2020 May 20.
Typ publikacji :
Case Reports
MeSH Terms :
Mutation*
DNA/*genetics
Proto-Oncogene Proteins c-kit/*genetics
Skin/*pathology
Urticaria Pigmentosa/*diagnosis
DNA Mutational Analysis ; Humans ; Infant ; Male ; Proto-Oncogene Proteins c-kit/metabolism ; Urticaria Pigmentosa/genetics
Raport
Tytuł :
Colour-sidedness in Gloucester cattle is associated with a complex structural variant impacting regulatory elements downstream of KIT.
Autorzy :
Artesi M; Unit of Animal Genomics, GIGA Institute, University of Liège, 1, avenue de l'hôpital, Liège, 4000, Belgium.
Tamma N; Unit of Animal Genomics, GIGA Institute, University of Liège, 1, avenue de l'hôpital, Liège, 4000, Belgium.
Deckers M; Unit of Animal Genomics, GIGA Institute, University of Liège, 1, avenue de l'hôpital, Liège, 4000, Belgium.
Karim L; Unit of Animal Genomics, GIGA Institute, University of Liège, 1, avenue de l'hôpital, Liège, 4000, Belgium.
Coppieters W; Unit of Animal Genomics, GIGA Institute, University of Liège, 1, avenue de l'hôpital, Liège, 4000, Belgium.
Van den Broeke A; Unit of Animal Genomics, GIGA Institute, University of Liège, 1, avenue de l'hôpital, Liège, 4000, Belgium.; Laboratory of Experimental Hematology, Institut Jules Bordet, Université Libre de Bruxelles, Boulevard de Waterloo 121, Brussels, 1000, Belgium.
Georges M; Unit of Animal Genomics, GIGA Institute, University of Liège, 1, avenue de l'hôpital, Liège, 4000, Belgium.
Charlier C; Unit of Animal Genomics, GIGA Institute, University of Liège, 1, avenue de l'hôpital, Liège, 4000, Belgium.
Durkin K; Unit of Animal Genomics, GIGA Institute, University of Liège, 1, avenue de l'hôpital, Liège, 4000, Belgium.
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Źródło :
Animal genetics [Anim Genet] 2020 Jun; Vol. 51 (3), pp. 461-465. Date of Electronic Publication: 2020 Apr 12.
Typ publikacji :
Journal Article
MeSH Terms :
Phenotype*
Regulatory Sequences, Nucleic Acid*
Cattle/*physiology
Hair Color/*genetics
Proto-Oncogene Proteins c-kit/*genetics
Animals ; Belgium ; Cattle/genetics ; Male ; Proto-Oncogene Proteins c-kit/metabolism
Czasopismo naukowe
Tytuł :
Mutation of the KIT Gene, excluding Exon 11, in Gastrointestinal Stromal Tumors.
Autorzy :
Liu QY; Departments of Pathology, Liver-Gallbladder-Pancreas Surgery, the People's Hospital of Zhengzhou University, Henan Provincial People's Hospital, Zhengzhou 450003, Henan, China.
Kong LF; Departments of Pathology, Liver-Gallbladder-Pancreas Surgery, the People's Hospital of Zhengzhou University, Henan Provincial People's Hospital, Zhengzhou 450003, Henan, China.
Xu ZG; Departments of Pathology, Liver-Gallbladder-Pancreas Surgery, the People's Hospital of Zhengzhou University, Henan Provincial People's Hospital, Zhengzhou 450003, Henan, China.
Li Z; Departments of Pathology, Liver-Gallbladder-Pancreas Surgery, the People's Hospital of Zhengzhou University, Henan Provincial People's Hospital, Zhengzhou 450003, Henan, China.
Xue HZ; Departments of Pathology, Liver-Gallbladder-Pancreas Surgery, the People's Hospital of Zhengzhou University, Henan Provincial People's Hospital, Zhengzhou 450003, Henan, China.
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Źródło :
Biomedical and environmental sciences : BES [Biomed Environ Sci] 2020 May 20; Vol. 33 (5), pp. 369-373.
Typ publikacji :
Letter
MeSH Terms :
Mutation*
Gastrointestinal Neoplasms/*genetics
Gastrointestinal Stromal Tumors/*genetics
Proto-Oncogene Proteins c-kit/*genetics
Adolescent ; Adult ; Aged ; Exons ; Female ; Humans ; Male ; Middle Aged ; Proto-Oncogene Proteins c-kit/metabolism ; Young Adult
Opinia redakcyjna
Tytuł :
Multidrug resistant gastrointestinal stromal tumor with multiple metastases to the skin and subcutaneous soft tissue: A case report and review of literature.
Autorzy :
Aickara DJ; Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery, Leonard M. Miller School of Medicine, University of Miami, Coral Gables, Florida.
McBride J; Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery, Leonard M. Miller School of Medicine, University of Miami, Coral Gables, Florida.
Morrison B; Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery, Leonard M. Miller School of Medicine, University of Miami, Coral Gables, Florida.
Romanelli P; Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery, Leonard M. Miller School of Medicine, University of Miami, Coral Gables, Florida.
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Źródło :
Journal of cutaneous pathology [J Cutan Pathol] 2020 Apr; Vol. 47 (4), pp. 398-401. Date of Electronic Publication: 2019 Nov 25.
Typ publikacji :
Case Reports
MeSH Terms :
Drug Resistance, Neoplasm*
Gastrointestinal Neoplasms*/drug therapy
Gastrointestinal Neoplasms*/genetics
Gastrointestinal Neoplasms*/metabolism
Gastrointestinal Neoplasms*/pathology
Gastrointestinal Stromal Tumors*/drug therapy
Gastrointestinal Stromal Tumors*/genetics
Gastrointestinal Stromal Tumors*/metabolism
Gastrointestinal Stromal Tumors*/pathology
Proto-Oncogene Proteins c-kit*/genetics
Proto-Oncogene Proteins c-kit*/metabolism
Skin Neoplasms*/genetics
Skin Neoplasms*/metabolism
Skin Neoplasms*/pathology
Skin Neoplasms*/secondary
Imatinib Mesylate/*administration & dosage
Protein Kinase Inhibitors/*administration & dosage
Sunitinib/*administration & dosage
Adult ; Aged ; Female ; Humans ; Male ; Middle Aged ; Mutation ; Neoplasm Metastasis
Raport
Tytuł :
Prediction of ovarian aging using ovarian expression of BMP15, GDF9, and C-KIT.
Autorzy :
Park MJ; Korea Institute for Public Sperm Bank, Busan 49241, Korea.
Ahn JW; Department of Obstetrics and Gynecology, College of Medicine, Ulsan University Hospital, Ulsan 44033, Korea.
Kim KH; Department of Obstetrics and Gynecology, Pusan National University School of Medicine, Pusan National University Hospital, Busan 49241, Korea.
Bang J; Department of Cardiothoracic Surgery, Dong-A University Hospital, Busan 602-812, Korea.
Kim SC; Department of Obstetrics and Gynecology, Pusan National University School of Medicine, Pusan National University Hospital, Busan 49241, Korea.
Jeong JY; Department of Obstetrics and Gynecology, Sungkyunkwan University School of Medicine, 51353 Changwon, Korea.
Choi YE; Department of Obstetrics and Gynecology, Sungkyunkwan University School of Medicine, 51353 Changwon, Korea.
Kim CW; Department of Obstetrics and Gynecology, Sungkyunkwan University School of Medicine, 51353 Changwon, Korea.
Joo BS; Korea Institute for Public Sperm Bank, Busan 49241, Korea.; Department of Cardiothoracic Surgery, Dong-A University Hospital, Busan 602-812, Korea.
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Źródło :
Experimental biology and medicine (Maywood, N.J.) [Exp Biol Med (Maywood)] 2020 Apr; Vol. 245 (8), pp. 711-719. Date of Electronic Publication: 2020 Mar 29.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Aging/*metabolism
Bone Morphogenetic Protein 15/*genetics
Growth Differentiation Factor 9/*genetics
Ovary/*metabolism
Proto-Oncogene Proteins c-kit/*genetics
Animals ; Bone Morphogenetic Protein 15/metabolism ; Female ; Growth Differentiation Factor 9/metabolism ; Mice ; Mice, Inbred C57BL ; Ovary/growth & development ; Proto-Oncogene Proteins c-kit/metabolism
Czasopismo naukowe
Tytuł :
Developing and Characterization of Chemically Modified RNA Aptamers for Targeting Wild Type and Mutated c-KIT Receptor Tyrosine Kinases.
Autorzy :
Shraim AS; Department of Biological Sciences, School of Science, The University of Jordan, Amman JO 11942, Jordan.; Department of Medical Laboratory Sciences, Faculty of Allied Medical Sciences, Al-Ahliyya Amman University, Amman JO 19328, Jordan.
Hunaiti A; Department of Clinical Laboratory Sciences, School of Science, The University of Jordan, Amman JO 11942, Jordan.
Awidi A; Cell Therapy Center, The University of Jordan, Amman JO 11942, Jordan.
Alshaer W; Cell Therapy Center, The University of Jordan, Amman JO 11942, Jordan.
Ababneh NA; Cell Therapy Center, The University of Jordan, Amman JO 11942, Jordan.
Abu-Irmaileh B; Hamdi Mango Center for Scientific Research, The University of Jordan, Amman JO 11942, Jordan.
Odeh F; Department of Chemistry, School of Science, The University of Jordan, Amman JO 11942, Jordan.
Ismail S; Department of Biochemistry and Physiology, School of Medicine, The University of Jordan, Amman JO 11942, Jordan.; Qatar Genome Project, Qatar Foundation, Doha, Qatar.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2020 Mar 12; Vol. 63 (5), pp. 2209-2228. Date of Electronic Publication: 2019 Aug 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Aptamers, Nucleotide/*pharmacology
Protein Kinase Inhibitors/*pharmacology
Proto-Oncogene Proteins c-kit/*antagonists & inhibitors
Aptamers, Nucleotide/chemistry ; Base Sequence ; Cell Line, Tumor ; Cell Survival/drug effects ; Humans ; Phosphorylation/drug effects ; Point Mutation ; Protein Kinase Inhibitors/chemistry ; Proto-Oncogene Proteins c-kit/genetics ; Proto-Oncogene Proteins c-kit/metabolism
Czasopismo naukowe
Tytuł :
Coordinated targeting of CK2 and KIT in gastrointestinal stromal tumours.
Autorzy :
Huang M; Zhejiang Provincial Key Laboratory of Silkworm Bioreactor and Biomedicine, College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou, China.
Yang W; Zhejiang Provincial Key Laboratory of Silkworm Bioreactor and Biomedicine, College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou, China.
Zhu J; Zhejiang Provincial Key Laboratory of Silkworm Bioreactor and Biomedicine, College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou, China.
Mariño-Enríquez A; Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Zhu C; Zhejiang Provincial Key Laboratory of Silkworm Bioreactor and Biomedicine, College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou, China.
Chen J; Zhejiang Provincial Key Laboratory of Silkworm Bioreactor and Biomedicine, College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou, China.
Wu Y; Zhejiang Provincial Key Laboratory of Silkworm Bioreactor and Biomedicine, College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou, China.
Quan Y; Zhejiang Provincial Key Laboratory of Silkworm Bioreactor and Biomedicine, College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou, China.
Qiu H; State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou, China.
Li X; Zhejiang Provincial Key Laboratory of Applied Enzymology, Yangtze Delta Region Institute of Tsinghua University, Jiaxing, Zhejiang, China.
Chai L; Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Fletcher JA; Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Ou WB; Zhejiang Provincial Key Laboratory of Silkworm Bioreactor and Biomedicine, College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou, China. .; Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. .; Zhejiang Provincial Key Laboratory of Applied Enzymology, Yangtze Delta Region Institute of Tsinghua University, Jiaxing, Zhejiang, China. .
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Źródło :
British journal of cancer [Br J Cancer] 2020 Feb; Vol. 122 (3), pp. 372-381. Date of Electronic Publication: 2019 Nov 28.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Casein Kinase II/*genetics
Cell Cycle Proteins/*metabolism
Chaperonins/*metabolism
Gastrointestinal Neoplasms/*genetics
Gastrointestinal Stromal Tumors/*genetics
HSP90 Heat-Shock Proteins/*metabolism
Proto-Oncogene Proteins c-kit/*genetics
Apoptosis/drug effects ; Apoptosis/genetics ; Casein Kinase II/antagonists & inhibitors ; Casein Kinase II/metabolism ; Cell Cycle/drug effects ; Cell Line, Tumor ; Cell Movement/drug effects ; Cell Movement/genetics ; Cell Survival/drug effects ; Cell Survival/genetics ; Gastrointestinal Neoplasms/metabolism ; Gastrointestinal Stromal Tumors/metabolism ; Gene Knockdown Techniques ; HSP90 Heat-Shock Proteins/drug effects ; Humans ; Imatinib Mesylate/pharmacology ; Naphthyridines/pharmacology ; Phosphatidylinositol 3-Kinases/metabolism ; Phosphorylation ; Protein Kinase Inhibitors/pharmacology ; Proto-Oncogene Proteins c-akt/metabolism ; Proto-Oncogene Proteins c-kit/antagonists & inhibitors ; Proto-Oncogene Proteins c-kit/metabolism ; Signal Transduction ; TOR Serine-Threonine Kinases/metabolism
Czasopismo naukowe
Tytuł :
c-KIT Analysis and Targeted Molecular Sequencing of Mesonephric Carcinomas of the Female Genital Tract.
Autorzy :
Pors J; Department of Anatomical Pathology, Vancouver General Hospital.
Ho J; Departments of Pathology and Laboratory Medicine.
Prentice L; Contextual Genomics.
Thompson E; Department of Anatomical Pathology, Vancouver General Hospital.
Cochrane D; Department of Molecular Oncology, British Columbia Cancer Research Centre.
Gibbard E; Medical Genetics, University of British Columbia.
Huntsman D; Contextual Genomics.; Department of Molecular Oncology, British Columbia Cancer Research Centre.
Gilks B; Department of Anatomical Pathology, Vancouver General Hospital.; Departments of Pathology and Laboratory Medicine.; Genetic Pathology Evaluation Center (GPEC), Vancouver, BC, Canada.
Hoang LN; Department of Anatomical Pathology, Vancouver General Hospital.; Departments of Pathology and Laboratory Medicine.; Medical Genetics, University of British Columbia.; Genetic Pathology Evaluation Center (GPEC), Vancouver, BC, Canada.
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Źródło :
The American journal of surgical pathology [Am J Surg Pathol] 2020 Apr; Vol. 44 (4), pp. 495-502.
Typ publikacji :
Journal Article
MeSH Terms :
Mutation*
Biomarkers, Tumor/*genetics
Carcinoma/*genetics
Genital Neoplasms, Female/*genetics
Proto-Oncogene Proteins c-kit/*genetics
Wolffian Ducts/*pathology
Aged ; Biomarkers, Tumor/analysis ; Carcinoma/enzymology ; Carcinoma/pathology ; Class I Phosphatidylinositol 3-Kinases/genetics ; DNA Mutational Analysis ; Female ; Genetic Predisposition to Disease ; Genital Neoplasms, Female/enzymology ; Genital Neoplasms, Female/pathology ; High-Throughput Nucleotide Sequencing ; Humans ; Immunohistochemistry ; Middle Aged ; Proto-Oncogene Proteins c-kit/analysis ; Proto-Oncogene Proteins p21(ras)/genetics ; Wolffian Ducts/enzymology ; beta Catenin/genetics
Czasopismo naukowe
Tytuł :
Kit activates interleukin-4 receptor and effector signal transducer and activator of transcription 6 independent of its cognate ligand in mouse mast cells.
Autorzy :
Sethumadhavan A; Cell Signaling Laboratory, Department of Microbiology, School of Life Sciences, Pondicherry University, Puducherry, India.
Mani M; Cell Signaling Laboratory, Department of Microbiology, School of Life Sciences, Pondicherry University, Puducherry, India.
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Źródło :
Immunology [Immunology] 2020 Apr; Vol. 159 (4), pp. 441-449. Date of Electronic Publication: 2020 Feb 07.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Interleukin-4/*pharmacology
Mast Cells/*drug effects
Proto-Oncogene Proteins c-kit/*genetics
Receptors, Interleukin-4/*genetics
STAT6 Transcription Factor/*genetics
Stem Cell Factor/*pharmacology
Animals ; Bone Marrow Cells/cytology ; Bone Marrow Cells/drug effects ; Bone Marrow Cells/immunology ; Cell Proliferation/drug effects ; Gene Expression Regulation ; Hematopoiesis/drug effects ; Hematopoiesis/genetics ; Hematopoiesis/immunology ; Interleukin-4/genetics ; Interleukin-4/immunology ; Mast Cells/cytology ; Mast Cells/immunology ; Membrane Microdomains/drug effects ; Membrane Microdomains/immunology ; Membrane Microdomains/metabolism ; Mice ; Mice, Inbred C57BL ; Primary Cell Culture ; Proto-Oncogene Proteins c-kit/immunology ; Receptors, Erythropoietin/genetics ; Receptors, Erythropoietin/immunology ; Receptors, Interleukin-3/genetics ; Receptors, Interleukin-3/immunology ; Receptors, Interleukin-4/immunology ; Receptors, Interleukin-7/genetics ; Receptors, Interleukin-7/immunology ; STAT6 Transcription Factor/immunology ; Signal Transduction ; Stem Cell Factor/genetics ; Stem Cell Factor/immunology ; beta-Cyclodextrins/pharmacology
Czasopismo naukowe
Tytuł :
TAS-116 inhibits oncogenic KIT signalling on the Golgi in both imatinib-naïve and imatinib-resistant gastrointestinal stromal tumours.
Autorzy :
Saito Y; Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, Suita, Japan.
Takahashi T; Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, Suita, Japan. .
Obata Y; National Cancer Center Hospital, Tsukiji, Japan.
Nishida T; National Cancer Center Hospital, Tsukiji, Japan.
Ohkubo S; Taiho Pharmaceutical Co. Ltd, Tsukuba, Japan.
Nakagawa F; Taiho Pharmaceutical Co. Ltd, Tsukuba, Japan.
Serada S; Kochi Medical School Hospital, Nankoku, Japan.
Fujimoto M; Kochi Medical School Hospital, Nankoku, Japan.
Ohkawara T; Kochi Medical School Hospital, Nankoku, Japan.
Nishigaki T; Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, Suita, Japan.
Sugase T; Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, Suita, Japan.
Koh M; Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, Suita, Japan.
Ishida T; Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, Suita, Japan.
Tanaka K; Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, Suita, Japan.
Miyazaki Y; Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, Suita, Japan.
Makino T; Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, Suita, Japan.
Kurokawa Y; Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, Suita, Japan.
Nakajima K; Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, Suita, Japan.
Yamasaki M; Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, Suita, Japan.
Hirota S; Department of Surgical Pathology, Hyogo College of Medicine, Nishinomiya, Japan.
Naka T; Kochi Medical School Hospital, Nankoku, Japan.
Mori M; Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, Suita, Japan.
Doki Y; Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, Suita, Japan.
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Źródło :
British journal of cancer [Br J Cancer] 2020 Mar; Vol. 122 (5), pp. 658-667. Date of Electronic Publication: 2019 Dec 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Benzamides/*pharmacology
Gastrointestinal Neoplasms/*drug therapy
Gastrointestinal Stromal Tumors/*drug therapy
Golgi Apparatus/*drug effects
Imatinib Mesylate/*pharmacology
Proto-Oncogene Proteins c-kit/*antagonists & inhibitors
Pyrazoles/*pharmacology
Animals ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Drug Resistance, Neoplasm ; ErbB Receptors/genetics ; ErbB Receptors/metabolism ; Gastrointestinal Neoplasms/genetics ; Gastrointestinal Neoplasms/metabolism ; Gastrointestinal Stromal Tumors/genetics ; Gastrointestinal Stromal Tumors/metabolism ; Golgi Apparatus/metabolism ; HSP90 Heat-Shock Proteins/antagonists & inhibitors ; HSP90 Heat-Shock Proteins/metabolism ; Humans ; Lung Neoplasms/drug therapy ; Lung Neoplasms/genetics ; Lung Neoplasms/metabolism ; Lung Neoplasms/pathology ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Mice, SCID ; Proto-Oncogene Proteins c-kit/metabolism ; Signal Transduction/drug effects ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Targeted therapies in melanoma beyond BRAF: targeting NRAS-mutated and KIT-mutated melanoma.
Autorzy :
Delyon J; Université de Paris, INSERM U976, Team 1, Human Immunology Pathophysiology & Immunotherapy (HIPI).; AP-HP Hôpital Saint Louis, Service de Dermatologie.
Lebbe C; Université de Paris, INSERM U976, Team 1, Human Immunology Pathophysiology & Immunotherapy (HIPI).; AP-HP Hôpital Saint Louis, Service de Dermatologie.
Dumaz N; INSERM, U976, Team 1, Human Immunology Pathophysiology & Immunotherapy (HIPI), Paris, France.
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Źródło :
Current opinion in oncology [Curr Opin Oncol] 2020 Mar; Vol. 32 (2), pp. 79-84.
Typ publikacji :
Journal Article; Review
MeSH Terms :
GTP Phosphohydrolases/*antagonists & inhibitors
Melanoma/*drug therapy
Membrane Proteins/*antagonists & inhibitors
Proto-Oncogene Proteins B-raf/*antagonists & inhibitors
Proto-Oncogene Proteins c-kit/*antagonists & inhibitors
Clinical Trials, Phase III as Topic ; GTP Phosphohydrolases/genetics ; Humans ; Melanoma/enzymology ; Melanoma/genetics ; Membrane Proteins/genetics ; Molecular Targeted Therapy ; Mutation ; Protein Kinase Inhibitors/therapeutic use ; Proto-Oncogene Proteins B-raf/genetics ; Proto-Oncogene Proteins c-kit/genetics ; Randomized Controlled Trials as Topic ; Skin Neoplasms/drug therapy ; Skin Neoplasms/enzymology ; Skin Neoplasms/genetics
Czasopismo naukowe
Tytuł :
Discovery of 8-Amino-Substituted 2-Phenyl-2,7-Naphthyridinone Derivatives as New c-Kit/VEGFR-2 Kinase Inhibitors.
Autorzy :
Sun H; Nanjing Polytechnic Institute, Nanjing 210048, China.
Zhuo L; Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, China.
Dong H; Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, China.
Huang W; Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, China.
She N; Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, China.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2019 Dec 05; Vol. 24 (24). Date of Electronic Publication: 2019 Dec 05.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Discovery*
Molecular Docking Simulation*
Protein Kinase Inhibitors*/chemical synthesis
Protein Kinase Inhibitors*/chemistry
Proto-Oncogene Proteins c-kit*/antagonists & inhibitors
Proto-Oncogene Proteins c-kit*/chemistry
Vascular Endothelial Growth Factor Receptor-2*/antagonists & inhibitors
Vascular Endothelial Growth Factor Receptor-2*/chemistry
Humans
Czasopismo naukowe

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