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Wyszukujesz frazę ""c-KIT"" wg kryterium: Temat


Tytuł:
In vivo hematopoietic stem cell modification by mRNA delivery.
Autorzy:
Breda L; Department of Pediatrics, Hematology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Papp TE; Division of Infectious Diseases, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Triebwasser MP; Department of Pediatrics, Hematology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Department of Pediatrics, The University of Michigan, Ann Arbor, MI, USA.
Yadegari A; Division of Infectious Diseases, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Fedorky MT; Department of Pediatrics, Hematology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Tanaka N; Department of Pediatrics, Hematology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Abdulmalik O; Department of Pediatrics, Hematology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Pavani G; Department of Pathology and Laboratory Medicine, Center for Cellular and Molecular Therapeutics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Wang Y; Department of Pathology and Laboratory Medicine, Transfusion Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Department of Clinical Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
Grupp SA; Division of Oncology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Departments of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Chou ST; Department of Pediatrics, Hematology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Department of Pathology and Laboratory Medicine, Transfusion Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Ni H; Division of Infectious Diseases, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Mui BL; Acuitas Therapeutics, Vancouver, BC V6T1Z3, Canada.
Tam YK; Acuitas Therapeutics, Vancouver, BC V6T1Z3, Canada.
Weissman D; Division of Infectious Diseases, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Rivella S; Department of Pediatrics, Hematology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, USA.; Cell and Molecular Biology affinity group, University of Pennsylvania, Philadelphia, PA, USA.; Raymond G. Perelman Center for Cellular and Molecular Therapeutics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Penn Center for Musculoskeletal Disorders, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Penn Institute for RNA Innovation, University of Pennsylvania, Philadelphia, PA, USA.
Parhiz H; Division of Infectious Diseases, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
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Źródło:
Science (New York, N.Y.) [Science] 2023 Jul 28; Vol. 381 (6656), pp. 436-443. Date of Electronic Publication: 2023 Jul 27.
Typ publikacji:
Journal Article
MeSH Terms:
Gene Editing*/methods
Hematopoietic Stem Cells*/metabolism
Proto-Oncogene Proteins c-kit*/genetics
RNA, Messenger*/genetics
Hematopoietic Stem Cell Transplantation ; Animals ; Humans ; Mice
Czasopismo naukowe
Tytuł:
KIT mutations and expression: current knowledge and new insights for overcoming IM resistance in GIST.
Autorzy:
Zhou S; Division of Oncology, Xiangya Hospital, Central South University, Changsha, Hunan, China, Xiangya road 87.
Abdihamid O; Garissa Cancer Center, Garissa County Referral Hospital, Kismayu road, Garissa town, P.O BOX, 29-70100, Kenya.
Tan F; Division of Surgery, Xiangya Hospital, Central South University, China, Hunan, Changsha.
Zhou H; Division of Pathology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Liu H; Division of Surgery, Xiangya Hospital, Central South University, China, Hunan, Changsha.
Li Z; Center for Molecular Medicine of Xiangya Hospital, Collaborative Innovation Center for Cancer Medicine, Central South University, Changsha, Hunan, China, 410008.
Xiao S; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, 410008, MA, USA.
Li B; Division of Oncology, Xiangya Hospital, Central South University, Changsha, Hunan, China, Xiangya road 87#. .
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Źródło:
Cell communication and signaling : CCS [Cell Commun Signal] 2024 Feb 27; Vol. 22 (1), pp. 153. Date of Electronic Publication: 2024 Feb 27.
Typ publikacji:
Video-Audio Media; Journal Article; Review; Research Support, Non-U.S. Gov't
MeSH Terms:
Gastrointestinal Stromal Tumors*/drug therapy
Gastrointestinal Stromal Tumors*/genetics
Gastrointestinal Stromal Tumors*/pathology
Antineoplastic Agents*/pharmacology
Antineoplastic Agents*/therapeutic use
Biological Products*
Humans ; Imatinib Mesylate/pharmacology ; Imatinib Mesylate/therapeutic use ; Epigenesis, Genetic ; Pyrimidines ; Proto-Oncogene Proteins c-kit/genetics ; Proto-Oncogene Proteins c-kit/metabolism ; Mutation/genetics ; Drug Resistance, Neoplasm/genetics ; Protein Kinase Inhibitors/pharmacology
Czasopismo naukowe
Tytuł:
Compensatory gene expression potentially rescues impaired brain development in Kit mutant mice.
Autorzy:
Minei R; Department of Bio-Science, Nagahama Institute of Bio-Science and Technology, Shiga, Japan.
Aoki H; Department of Tissue and Organ Development, Regeneration, and Advanced Medical Science, Graduate School of Medicine, Gifu University, 1-1 Yanagido, Gifu, 501-1194, Japan.
Ogura A; Department of Bio-Science, Nagahama Institute of Bio-Science and Technology, Shiga, Japan.
Kunisada T; Department of Tissue and Organ Development, Regeneration, and Advanced Medical Science, Graduate School of Medicine, Gifu University, 1-1 Yanagido, Gifu, 501-1194, Japan. .
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Źródło:
Scientific reports [Sci Rep] 2023 Mar 13; Vol. 13 (1), pp. 4166. Date of Electronic Publication: 2023 Mar 13.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Brain*/growth & development
Proto-Oncogene Proteins c-kit*/genetics
Proto-Oncogene Proteins c-kit*/metabolism
Animals ; Mice ; Gene Expression ; Mice, Mutant Strains ; Mutation ; Phenotype
Czasopismo naukowe
Tytuł:
NTRK2 expression in gastrointestinal stromal tumors with a special emphasis on the clinicopathological and prognostic impacts.
Autorzy:
Sasa K; Department of Human Pathology, Juntendo University School of Medicine, Tokyo, Japan.; Department of Medicine for Orthopaedics and Motor Organ, Juntendo University School of Medicine, Tokyo, Japan.
Son R; RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Oguchi A; RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Ashizawa K; Department of Human Pathology, Juntendo University School of Medicine, Tokyo, Japan.
Hasegawa N; Department of Medicine for Orthopaedics and Motor Organ, Juntendo University School of Medicine, Tokyo, Japan.
Kubota D; Department of Medicine for Orthopaedics and Motor Organ, Juntendo University School of Medicine, Tokyo, Japan.
Suehara Y; Department of Medicine for Orthopaedics and Motor Organ, Juntendo University School of Medicine, Tokyo, Japan.
Takagi T; Department of Medicine for Orthopaedics and Motor Organ, Juntendo University School of Medicine, Tokyo, Japan.
Okubo T; Department of Medicine for Orthopaedics and Motor Organ, Juntendo University School of Medicine, Tokyo, Japan.
Akaike K; Department of Medicine for Orthopaedics and Motor Organ, Juntendo University School of Medicine, Tokyo, Japan.; Department of Orthopaedic Surgery, Yamanashi Central Hospital, Yamanashi, Japan.
Sugimoto K; Department of Coloproctological Surgery, Graduate School of Medicine, Juntendo University, Tokyo, 113-8421, Japan.
Takahashi M; Department of Coloproctological Surgery, Graduate School of Medicine, Juntendo University, Tokyo, 113-8421, Japan.
Sakamoto K; Department of Coloproctological Surgery, Graduate School of Medicine, Juntendo University, Tokyo, 113-8421, Japan.
Hashimoto T; Department of Upper Gastroenterological Surgery, Juntendo University Hospital, Bunkyo-ku, Tokyo, 113-8431, Japan.
Mine S; Department of Upper Gastroenterological Surgery, Juntendo University Hospital, Bunkyo-ku, Tokyo, 113-8431, Japan.
Fukunaga T; Department of Upper Gastroenterological Surgery, Juntendo University Hospital, Bunkyo-ku, Tokyo, 113-8431, Japan.
Ishijima M; Department of Medicine for Orthopaedics and Motor Organ, Juntendo University School of Medicine, Tokyo, Japan.; Intractable Disease Research Center, Graduate School of Medicine, Juntendo University, Tokyo, 113-8421, Japan.
Hayashi T; Department of Human Pathology, Juntendo University School of Medicine, Tokyo, Japan.
Yao T; Department of Human Pathology, Juntendo University School of Medicine, Tokyo, Japan.
Murakawa Y; RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.; Institute for the Advanced Study of Human Biology (ASHBi), Kyoto University, Kyoto, Japan.; IFOM ETS - the AIRC Institute of Molecular Oncology, Milan, Italy.
Saito T; Department of Human Pathology, Juntendo University School of Medicine, Tokyo, Japan. .; Intractable Disease Research Center, Graduate School of Medicine, Juntendo University, Tokyo, 113-8421, Japan. .
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Źródło:
Scientific reports [Sci Rep] 2024 Jan 08; Vol. 14 (1), pp. 768. Date of Electronic Publication: 2024 Jan 08.
Typ publikacji:
Journal Article
MeSH Terms:
Gastrointestinal Stromal Tumors*/genetics
Humans ; Prognosis ; Receptor Protein-Tyrosine Kinases ; Proto-Oncogenes ; Proto-Oncogene Proteins c-kit
Czasopismo naukowe
Tytuł:
Chinese Pedigree with Hereditary Gastrointestinal Stromal Tumors: A Case Report and Literature Review.
Autorzy:
Ge Q; Department of Gastroenterology, Shengjing Hospital of China Medical University, 36 Sanhao Street, Shenyang 110004, China.; Innovative Research Center for Integrated Cancer Omics, Shengjing Hospital of China Medical University, Shenyang 110004, China.
Liu Y; Department of Gastroenterology, Shengjing Hospital of China Medical University, 36 Sanhao Street, Shenyang 110004, China.; Innovative Research Center for Integrated Cancer Omics, Shengjing Hospital of China Medical University, Shenyang 110004, China.
Yang F; Department of Gastroenterology, Shengjing Hospital of China Medical University, 36 Sanhao Street, Shenyang 110004, China.
Sun G; Innovative Engineering Technology Research Center for Cell Therapy, Shengjing Hospital of China Medical University, Shenyang 110022, China.
Guo J; Department of Gastroenterology, Shengjing Hospital of China Medical University, 36 Sanhao Street, Shenyang 110004, China.
Sun S; Department of Gastroenterology, Shengjing Hospital of China Medical University, 36 Sanhao Street, Shenyang 110004, China.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Jan 03; Vol. 24 (1). Date of Electronic Publication: 2023 Jan 03.
Typ publikacji:
Review; Case Reports
MeSH Terms:
Drug Resistance, Neoplasm*/genetics
Gastrointestinal Neoplasms*/drug therapy
Gastrointestinal Neoplasms*/genetics
Gastrointestinal Stromal Tumors*/drug therapy
Gastrointestinal Stromal Tumors*/genetics
Neoplastic Syndromes, Hereditary*/drug therapy
Neoplastic Syndromes, Hereditary*/genetics
Proto-Oncogene Proteins c-kit*/genetics
Humans ; Male ; Middle Aged ; Hyperpigmentation/genetics ; Mutation ; Pedigree ; China
Recenzja
Tytuł:
A Review of the Clinical Features and Management of Systemic Congenital Mastocytosis through the Presentation of An Unusual Prenatal-Onset Case.
Autorzy:
Larouche V; Department of Pediatric Hemato-oncology, Centre Hospitalier Universitaire de Quebec-Université Laval, Quebec, QC G1V4G2, Canada.
Paré MF; Medecine Faculty, Laval University, Quebec, QC G1V4G2, Canada.
Grenier PO; Department of Dermatology, Centre Hospitalier Universitaire de Quebec-Université Laval, Quebec, QC G1V4G2, Canada.
Wieckowska A; Departement of Pediatric, Centre Hospitalier Universitaire de Quebec-Université Laval, Quebec, QC G1V4G2, Canada.
Gagné E; Department of Pathology, Centre Hospitalier Universitaire de Quebec-Université Laval, Quebec, QC G1V4G2, Canada.
Laframboise R; Department of Medical Genetics, Centre Hospitalier Universitaire de Quebec-Université Laval, Quebec, QC G1V4G2, Canada.
Jabado N; Department of Pediatric Hemato-Oncology, Montreal Children's Hospital, McGill University Health Centre, Montreal, QC G1V4G2, Canada.
De Bie I; Division of Medical Genetics, Department of Specialized Medicine, McGill University Health Centre, Montreal, QC G1V4G2, Canada.
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Źródło:
Current oncology (Toronto, Ont.) [Curr Oncol] 2023 Oct 03; Vol. 30 (10), pp. 8992-9003. Date of Electronic Publication: 2023 Oct 03.
Typ publikacji:
Review; Case Reports
MeSH Terms:
Congenital Microtia*
Mastocytosis, Systemic*/diagnosis
Mastocytosis, Systemic*/genetics
Mastocytosis, Systemic*/drug therapy
Mastocytosis*/genetics
Mastocytosis, Cutaneous*/drug therapy
Mastocytosis, Cutaneous*/pathology
Female ; Humans ; Child ; Adolescent ; Proto-Oncogene Proteins c-kit/genetics ; Proto-Oncogene Proteins c-kit/therapeutic use
Recenzja
Tytuł:
Lin defines haematopoietic stem cells with long-term multilineage reconstitution activity.
Autorzy:
Xu H; State Key Laboratory of Stem Cell and Reproductive Biology, Institute for Stem Cell and Regeneration, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.; Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, China.; University of Chinese Academy of Sciences, Beijing, China.
Tan S; State Key Laboratory of Stem Cell and Reproductive Biology, Institute for Stem Cell and Regeneration, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.; Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, China.; University of Chinese Academy of Sciences, Beijing, China.
Zhao Y; State Key Laboratory of Stem Cell and Reproductive Biology, Institute for Stem Cell and Regeneration, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.; Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, China.; University of Chinese Academy of Sciences, Beijing, China.
Zhang L; State Key Laboratory of Stem Cell and Reproductive Biology, Institute for Stem Cell and Regeneration, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.; Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, China.; University of Chinese Academy of Sciences, Beijing, China.
Cao W; State Key Laboratory of Stem Cell and Reproductive Biology, Institute for Stem Cell and Regeneration, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.; Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, China.; University of Chinese Academy of Sciences, Beijing, China.
Li X; State Key Laboratory of Stem Cell and Reproductive Biology, Institute for Stem Cell and Regeneration, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.; Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, China.; University of Chinese Academy of Sciences, Beijing, China.
Tian J; State Key Laboratory of Stem Cell and Reproductive Biology, Institute for Stem Cell and Regeneration, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.; Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, China.; University of Chinese Academy of Sciences, Beijing, China.
Wang X; State Key Laboratory of Stem Cell and Reproductive Biology, Institute for Stem Cell and Regeneration, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.; Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, China.; University of Chinese Academy of Sciences, Beijing, China.
Li X; State Key Laboratory of Stem Cell and Reproductive Biology, Institute for Stem Cell and Regeneration, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.; University of Chinese Academy of Sciences, Beijing, China.
Wang F; National Institute of Biological Sciences (NIBS), Beijing, China.
Cao J; State Key Laboratory of Stem Cell and Reproductive Biology, Institute for Stem Cell and Regeneration, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.; Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, China.; University of Chinese Academy of Sciences, Beijing, China.
Zhao T; State Key Laboratory of Stem Cell and Reproductive Biology, Institute for Stem Cell and Regeneration, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.; Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, China.; University of Chinese Academy of Sciences, Beijing, China.
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Źródło:
Cell proliferation [Cell Prolif] 2023 Nov; Vol. 56 (11), pp. e13490. Date of Electronic Publication: 2023 May 05.
Typ publikacji:
Journal Article
MeSH Terms:
Hematopoietic Stem Cells*/metabolism
Receptor Protein-Tyrosine Kinases*
Mice ; Animals ; Cell Lineage ; Proto-Oncogene Proteins c-kit/metabolism ; Bone Marrow Cells/metabolism ; Mice, Inbred C57BL
Czasopismo naukowe
Tytuł:
Personalized radiomics signature to screen for KIT-11 mutation genotypes among patients with gastrointestinal stromal tumors: a retrospective multicenter study.
Autorzy:
Zhang QW; Division of Gastroenterology and Hepatology, Shanghai Institute of Digestive Disease, NHC Key Laboratory of Digestive Diseases, State Key Laboratory for Oncogenes and Related Genes, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Zhang RY; Department of Radiology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Yan ZB; Department of General Surgery, Qilu Hospital of Shandong University, Jinan, China.
Zhao YX; Department of Radiology, Qilu Hospital of Shandong University, Jinan, China.
Wang XY; Division of Gastroenterology and Hepatology, Shanghai Institute of Digestive Disease, NHC Key Laboratory of Digestive Diseases, State Key Laboratory for Oncogenes and Related Genes, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Jin JZ; Division of Gastroenterology and Hepatology, Shanghai Institute of Digestive Disease, NHC Key Laboratory of Digestive Diseases, State Key Laboratory for Oncogenes and Related Genes, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Qiu QX; Department of Radiology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Chen JJ; Department of Radiology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Xie ZH; Department of Radiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, No. 160, Pujian Rd., Shanghai, 200127, China.
Lin J; Department of Radiology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China. .
Cao H; Department of Gastrointestinal Surgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, No. 160 Pujian Road, Shanghai, 200127, China. .
Zhou Y; Department of Radiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, No. 160, Pujian Rd., Shanghai, 200127, China. .
Chen HM; Division of Gastroenterology and Hepatology, Shanghai Institute of Digestive Disease, NHC Key Laboratory of Digestive Diseases, State Key Laboratory for Oncogenes and Related Genes, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. .
Li XB; Division of Gastroenterology and Hepatology, Shanghai Institute of Digestive Disease, NHC Key Laboratory of Digestive Diseases, State Key Laboratory for Oncogenes and Related Genes, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. lixb_.
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Źródło:
Journal of translational medicine [J Transl Med] 2023 Oct 16; Vol. 21 (1), pp. 726. Date of Electronic Publication: 2023 Oct 16.
Typ publikacji:
Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
MeSH Terms:
Gastrointestinal Stromal Tumors*/diagnostic imaging
Gastrointestinal Stromal Tumors*/drug therapy
Gastrointestinal Stromal Tumors*/genetics
Humans ; Genotype ; Imatinib Mesylate ; Mutation/genetics ; Proto-Oncogene Proteins c-kit/genetics ; Receptor Protein-Tyrosine Kinases ; Retrospective Studies
Czasopismo naukowe
Tytuł:
Antibody-Based and Cell Therapies for Advanced Mastocytosis: Established and Novel Concepts.
Autorzy:
Valent P; Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, 1090 Vienna, Austria.; Ludwig Boltzmann Institute for Hematology and Oncology, Medical University of Vienna, 1090 Vienna, Austria.
Akin C; Division of Allergy and Clinical Immunology, University of Michigan, Ann Arbor, MI 48106, USA.
Arock M; Department of Hematological Biology, Pitié-Salpêtrière Hospital, Sorbonne University, 75013 Paris, France.
Gleixner KV; Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, 1090 Vienna, Austria.; Ludwig Boltzmann Institute for Hematology and Oncology, Medical University of Vienna, 1090 Vienna, Austria.
Greinix H; Division of Hematology, Medical University of Graz, 8010 Graz, Austria.
Hermine O; Service d'Hématologie, Imagine Institute Université de Paris, INSERM U1163, Centre National de Référence des Mastocytoses, Hôpital Necker, Assistance Publique Hôpitaux de Paris, 75015 Paris, France.
Horny HP; Institute of Pathology, Ludwig-Maximilians University, 80539 Munich, Germany.
Ivanov D; Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, 1090 Vienna, Austria.; Ludwig Boltzmann Institute for Hematology and Oncology, Medical University of Vienna, 1090 Vienna, Austria.
Orfao A; Servicio Central de Citometria, Centro de Investigacion del Cancer (IBMCC; CSIC/USAL) Instituto Biosanitario de Salamanca (IBSAL), CIBERONC and Department of Medicine, University of Salamanca, 37007 Salamanca, Spain.
Rabitsch W; Department of Internal Medicine I, Stem Cell Transplantation Unit, Medical University of Vienna, 1090 Vienna, Austria.
Reiter A; Department of Hematology and Oncology, University Hospital Mannheim, 68135 Mannheim, Germany.
Schulenburg A; Department of Internal Medicine I, Stem Cell Transplantation Unit, Medical University of Vienna, 1090 Vienna, Austria.
Sotlar K; Institute of Pathology, University Hospital Salzburg, Paracelsus Medical University, 5020 Salzburg, Austria.
Sperr WR; Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, 1090 Vienna, Austria.; Ludwig Boltzmann Institute for Hematology and Oncology, Medical University of Vienna, 1090 Vienna, Austria.
Ustun C; Department of Medicine, Division of Hematology, Oncology, and Cell Therapy, Coleman Foundation Blood and Marrow Transplant Center at Rush University Medical Center, Chicago, IL 60612, USA.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Oct 12; Vol. 24 (20). Date of Electronic Publication: 2023 Oct 12.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Mastocytosis*/genetics
Mastocytosis*/therapy
Mastocytosis, Systemic*/therapy
Mastocytosis, Systemic*/drug therapy
Humans ; Quality of Life ; Mast Cells ; Mutation ; Proto-Oncogene Proteins c-kit/genetics
Czasopismo naukowe
Tytuł:
Jejunal gastrointestinal stromal tumor that developed in a patient with neurofibromatosis type 1: a case report.
Autorzy:
Nagano H; Department of Surgery, Marunouchi Hospital, 1-7-45, Nagisa Matsumoto, Nagano, 390-0841, Japan. .
Ohyama S; Department of Surgery, Marunouchi Hospital, 1-7-45, Nagisa Matsumoto, Nagano, 390-0841, Japan.
Sato A; Department of Surgery, Marunouchi Hospital, 1-7-45, Nagisa Matsumoto, Nagano, 390-0841, Japan.
Igarashi J; Department of Surgery, Marunouchi Hospital, 1-7-45, Nagisa Matsumoto, Nagano, 390-0841, Japan.
Yamamoto T; Department of Surgery, Marunouchi Hospital, 1-7-45, Nagisa Matsumoto, Nagano, 390-0841, Japan.
Kadoya M; Department of Radiology, Marunouchi Hospital, Matsumoto Nagano, Japan.
Kobayashi M; Department of Pathology, Marunouchi Hospital, Matsumoto Nagano, Japan.
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Źródło:
Diagnostic pathology [Diagn Pathol] 2023 Oct 03; Vol. 18 (1), pp. 110. Date of Electronic Publication: 2023 Oct 03.
Typ publikacji:
Case Reports; Journal Article
MeSH Terms:
Gastrointestinal Stromal Tumors*/pathology
Neurofibromatosis 1*/complications
Neurofibromatosis 1*/diagnosis
Neurofibromatosis 1*/genetics
Female ; Humans ; Jejunum/pathology ; Intestine, Small/pathology ; Mutation ; Proto-Oncogene Proteins c-kit/genetics ; Receptor, Platelet-Derived Growth Factor alpha/genetics
Czasopismo naukowe
Tytuł:
Protective Effects of Aqueous Extracts of the Herb of Paederia scandens (Lour.) Merr. against HCl/EtOH-Induced Gastric Ulcer in Rats: Involvement and Inhibitors' Identification of NF-κB Signaling.
Autorzy:
Li, Qingxia (AUTHOR)
Guo, Hui (AUTHOR)
Gong, Man (AUTHOR)
Zhang, Yang (AUTHOR)
Yang, Lianhe (AUTHOR)
Wang, Jing (AUTHOR)
Wang, Pei (AUTHOR)
Wang, Zhimin (AUTHOR)
Xu, Erping (AUTHOR)
Dai, Liping (AUTHOR)
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Źródło:
Journal of Food Biochemistry. 7/4/2023, p1-15. 15p.
Czasopismo naukowe
Tytuł:
Pharmacology and Rationale for Seralutinib in the Treatment of Pulmonary Arterial Hypertension.
Autorzy:
Pullamsetti SS; Lung Vascular Epigenetics, Center for Infection and Genomics of the Lung (CIGL), Justus-Liebig-Universität Gießen, Aulweg 132, 35392 Giessen, Germany.
Sitapara R; Gossamer Bio, Inc., San Diego, CA 92121, USA.
Osterhout R; Gossamer Bio, Inc., San Diego, CA 92121, USA.
Weiss A; UGMLC Pulmonale Pharmakotherapie, Biomedizinisches Forschungszentrum Seltersberg (BFS), Justus-Liebig-Universität Gießen, Schubertstraße 81, 35392 Giessen, Germany.
Carter LL; Gossamer Bio, Inc., San Diego, CA 92121, USA.
Zisman LS; Gossamer Bio, Inc., San Diego, CA 92121, USA.
Schermuly RT; Department of Internal Medicine, Justus-Liebig-University Giessen, Aulweg 130, 35392 Giessen, Germany.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Aug 10; Vol. 24 (16). Date of Electronic Publication: 2023 Aug 10.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Pulmonary Arterial Hypertension*
Humans ; Endothelial Cells ; Familial Primary Pulmonary Hypertension ; Protein Kinase Inhibitors ; Receptor Protein-Tyrosine Kinases ; Proto-Oncogene Proteins c-kit
Czasopismo naukowe
Tytuł:
Meteorin-like promotes heart repair through endothelial KIT receptor tyrosine kinase.
Autorzy:
Reboll MR; Division of Molecular and Translational Cardiology, Hans Borst Center for Heart and Stem Cell Research, Hannover Medical School, 30625 Hannover, Germany.; Department of Cardiology and Angiology, Hannover Medical School, 30625 Hannover, Germany.
Klede S; Division of Molecular and Translational Cardiology, Hans Borst Center for Heart and Stem Cell Research, Hannover Medical School, 30625 Hannover, Germany.; Department of Cardiology and Angiology, Hannover Medical School, 30625 Hannover, Germany.
Taft MH; Institute for Biophysical Chemistry, Hannover Medical School, 30625 Hannover, Germany.
Cai CL; Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Field LJ; Krannert Cardiovascular Research Center and the Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Lavine KJ; Center for Cardiovascular Research, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Koenig AL; Center for Cardiovascular Research, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Fleischauer J; Institute of Experimental Hematology, Hannover Medical School, 30625 Hannover, Germany.
Meyer J; Institute of Experimental Hematology, Hannover Medical School, 30625 Hannover, Germany.
Schambach A; Institute of Experimental Hematology, Hannover Medical School, 30625 Hannover, Germany.
Niessen HW; Department of Pathology and Department of Cardiac Surgery, Institute for Cardiovascular Research, Amsterdam University Medical Center, 1007 MB Amsterdam, Netherlands.
Kosanke M; Research Core Unit Genomics, Hannover Medical School, 30625 Hannover, Germany.
van den Heuvel J; Technology Platform Recombinant Protein Expression, Helmholtz Center for Infection Research, 38124 Braunschweig, Germany.
Pich A; Core Unit Proteomics and Institute of Toxicology, Hannover Medical School, 30625 Hannover, Germany.
Bauersachs J; Department of Cardiology and Angiology, Hannover Medical School, 30625 Hannover, Germany.
Wu X; Division of Molecular and Translational Cardiology, Hans Borst Center for Heart and Stem Cell Research, Hannover Medical School, 30625 Hannover, Germany.; Department of Cardiology and Angiology, Hannover Medical School, 30625 Hannover, Germany.
Zheng L; Division of Molecular and Translational Cardiology, Hans Borst Center for Heart and Stem Cell Research, Hannover Medical School, 30625 Hannover, Germany.; Department of Cardiology and Angiology, Hannover Medical School, 30625 Hannover, Germany.
Wang Y; Division of Molecular and Translational Cardiology, Hans Borst Center for Heart and Stem Cell Research, Hannover Medical School, 30625 Hannover, Germany.; Department of Cardiology and Angiology, Hannover Medical School, 30625 Hannover, Germany.
Korf-Klingebiel M; Division of Molecular and Translational Cardiology, Hans Borst Center for Heart and Stem Cell Research, Hannover Medical School, 30625 Hannover, Germany.; Department of Cardiology and Angiology, Hannover Medical School, 30625 Hannover, Germany.
Polten F; Division of Molecular and Translational Cardiology, Hans Borst Center for Heart and Stem Cell Research, Hannover Medical School, 30625 Hannover, Germany.; Department of Cardiology and Angiology, Hannover Medical School, 30625 Hannover, Germany.
Wollert KC; Division of Molecular and Translational Cardiology, Hans Borst Center for Heart and Stem Cell Research, Hannover Medical School, 30625 Hannover, Germany.; Department of Cardiology and Angiology, Hannover Medical School, 30625 Hannover, Germany.
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Źródło:
Science (New York, N.Y.) [Science] 2022 Jun 17; Vol. 376 (6599), pp. 1343-1347. Date of Electronic Publication: 2022 Jun 16.
Typ publikacji:
Journal Article
MeSH Terms:
Adipokines*
Cytokines*/genetics
Cytokines*/metabolism
Myocardial Infarction*/complications
Myocardial Infarction*/physiopathology
Neovascularization, Physiologic*
Nerve Growth Factors*/genetics
Nerve Growth Factors*/metabolism
Proto-Oncogene Proteins c-kit*/metabolism
Animals ; Cells, Cultured ; Endothelial Cells/metabolism ; Heart Failure/etiology ; Heart Failure/genetics ; Ligands ; Macrophages/metabolism ; Mice ; Mice, Mutant Strains
Czasopismo naukowe
Tytuł:
Small Molecule c-KIT Inhibitors for the Treatment of Gastrointestinal Stromal Tumors: A Review on Synthesis, Design Strategies, and Structure-Activity Relationship (SAR).
Autorzy:
Godesi S; BK21 FOUR Team and Integrated Research Institute for Drug Development, College of Pharmacy, Dongguk University-Seoul, Goyang 10326, Republic of Korea.
Lee J; BK21 FOUR Team and Integrated Research Institute for Drug Development, College of Pharmacy, Dongguk University-Seoul, Goyang 10326, Republic of Korea.
Nada H; BK21 FOUR Team and Integrated Research Institute for Drug Development, College of Pharmacy, Dongguk University-Seoul, Goyang 10326, Republic of Korea.
Quan G; BK21 FOUR Team and Integrated Research Institute for Drug Development, College of Pharmacy, Dongguk University-Seoul, Goyang 10326, Republic of Korea.
Elkamhawy A; BK21 FOUR Team and Integrated Research Institute for Drug Development, College of Pharmacy, Dongguk University-Seoul, Goyang 10326, Republic of Korea.; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt.
Choi Y; College of Biosciences and Biotechnology, Korea University, Seoul 02841, Republic of Korea.
Lee K; BK21 FOUR Team and Integrated Research Institute for Drug Development, College of Pharmacy, Dongguk University-Seoul, Goyang 10326, Republic of Korea.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 May 29; Vol. 24 (11). Date of Electronic Publication: 2023 May 29.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Gastrointestinal Stromal Tumors*/genetics
Gastrointestinal Neoplasms*/genetics
Humans ; Enzyme Inhibitors/pharmacology ; Proto-Oncogene Proteins c-kit/genetics ; Structure-Activity Relationship ; Oncogenes ; Mutation ; Receptor, Platelet-Derived Growth Factor alpha/genetics
Czasopismo naukowe
Tytuł:
Salivary Cystatin D Interactome in Patients with Systemic Mastocytosis: An Exploratory Study.
Autorzy:
Serrao S; Department of Life and Environmental Sciences, University of Cagliari, 09124 Cagliari, Italy.
Contini C; Department of Life and Environmental Sciences, University of Cagliari, 09124 Cagliari, Italy.
Guadalupi G; Department of Life and Environmental Sciences, University of Cagliari, 09124 Cagliari, Italy.
Olianas A; Department of Life and Environmental Sciences, University of Cagliari, 09124 Cagliari, Italy.
Lai G; Department of Life and Environmental Sciences, University of Cagliari, 09124 Cagliari, Italy.
Messana I; Istituto di Scienze e Tecnologie Chimiche 'Giulio Natta', Consiglio Nazionale delle Ricerche, 00168 Rome, Italy.
Castagnola M; Proteomics Laboratory, European Center for Brain Research, (IRCCS) Santa Lucia Foundation, 00168 Rome, Italy.
Costanzo G; Department of Medical Sciences and Public Health, 09124 Cagliari, Italy.
Firinu D; Department of Medical Sciences and Public Health, 09124 Cagliari, Italy.
Del Giacco S; Department of Medical Sciences and Public Health, 09124 Cagliari, Italy.
Manconi B; Department of Life and Environmental Sciences, University of Cagliari, 09124 Cagliari, Italy.
Cabras T; Department of Life and Environmental Sciences, University of Cagliari, 09124 Cagliari, Italy.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Sep 27; Vol. 24 (19). Date of Electronic Publication: 2023 Sep 27.
Typ publikacji:
Journal Article
MeSH Terms:
Mastocytosis, Systemic*/diagnosis
Mastocytosis*/diagnosis
Humans ; Salivary Cystatins/analysis ; Proteomics ; Mast Cells ; Proto-Oncogene Proteins c-kit
Czasopismo naukowe
Tytuł:
A Rare PDGFRA Exon 15 Germline Mutation Identified in a Patient With Phenotypic Manifestations Concerning for GIST-Plus Syndrome: A Case Report and Review of Literature.
Autorzy:
Wang C; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.; Department of Pathology and Laboratory Medicine, The Ottawa Hospital, University of Ottawa, Ottawa, ON, Canada.
Yantiss RK; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.; Department of Pathology and Laboratory Medicine, University of Miami Miller School of Medicine, Miami, FL, USA.
Lieberman MD; Department of Surgery, Weill Cornell Medicine, New York, NY, USA.
Tubito-Massarano F; Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
Qin L; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.
Yemelyanova A; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.
Solomon JP; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.
Hissong E; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.
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Źródło:
International journal of surgical pathology [Int J Surg Pathol] 2023 Sep; Vol. 31 (6), pp. 1139-1145. Date of Electronic Publication: 2023 Feb 19.
Typ publikacji:
Review; Case Reports; Journal Article
MeSH Terms:
Gastrointestinal Stromal Tumors*/diagnosis
Gastrointestinal Stromal Tumors*/genetics
Gastrointestinal Stromal Tumors*/pathology
Gastrointestinal Neoplasms*/diagnosis
Gastrointestinal Neoplasms*/genetics
Gastrointestinal Neoplasms*/pathology
Female ; Humans ; Middle Aged ; Germ-Line Mutation ; Mutation ; Receptor Protein-Tyrosine Kinases ; Exons/genetics ; Proto-Oncogene Proteins c-kit
Czasopismo naukowe
Tytuł:
REGISTRI: Regorafenib in first-line of KIT/PDGFRA wild type metastatic GIST: a collaborative Spanish (GEIS), Italian (ISG) and French Sarcoma Group (FSG) phase II trial.
Autorzy:
Martin-Broto J; Health Research Institute-Fundación Jiménez Díaz University Hospital, Universidad Autonoma de Madrid (IIS-FJD, UAM), 28040, Madrid, Spain. .; Medical Oncology Department, Fundación Jimenez Diaz University Hospital, Av. de los Reyes Católicos, 2, 28040, Madrid, Spain. .; General de Villalba University Hospital, 28400, Madrid, Spain. .
Valverde C; Medical Oncology department, Vall d'Hebron University Hospital, 08035, Barcelona, Spain.
Hindi N; Health Research Institute-Fundación Jiménez Díaz University Hospital, Universidad Autonoma de Madrid (IIS-FJD, UAM), 28040, Madrid, Spain.; Medical Oncology Department, Fundación Jimenez Diaz University Hospital, Av. de los Reyes Católicos, 2, 28040, Madrid, Spain.; General de Villalba University Hospital, 28400, Madrid, Spain.
Vincenzi B; Medical Oncology, University Campus Bio-Medico and Fondazione Policlinico Universitario Campus Bio-Medico, 00128, Rome, Italy.
Martinez-Trufero J; Medical Oncology Department, University Hospital Miguel Servet, 50009, Zaragoza, Spain.
Grignani G; Medical Oncology Unit, Città della Salute e della Scienza Hospital, 10126, Turin, Italy.
Italiano A; Medical Oncology department, Institute Bergonié, 33076, Bordeaux, France.
Lavernia J; Medical Oncology department, Fundación Instituto Valenciano de Oncologia, 46009, Valencia, Spain.
Vallejo A; Pathology department, Hospital Regional Universitario de Malaga, 29010, Malaga, Spain.
Tos PD; Department of Medicine, School of Medicine, University of Padua, 35122, Padua, Italy.
Le Loarer F; Pathology department, Institute Bergonié, 33076, Bordeaux, France.
Gonzalez-Campora R; Pathology department, Hospital Quironsalud, 14004, Cordoba, Cordoba, Spain.
Ramos R; Pathology department, University Hospital Son Espases, 07120, Mallorca, Spain.
Hernández-Jover D; Radiology department, Sant Pau University Hospital, 08025, Barcelona, Spain.
Gutierrez A; Hematology department, University Hospital Son Espases, 07120, Mallorca, Spain.
Serrano C; Medical Oncology department, Vall d'Hebron University Hospital, 08035, Barcelona, Spain.
Monteagudo M; Hereditary Endocrine Cancer Group, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.
Letón R; Hereditary Endocrine Cancer Group, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.
Robledo M; Hereditary Endocrine Cancer Group, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Institute of Health Carlos III (ISCIII), Madrid, Spain.
Moura DS; Health Research Institute-Fundación Jiménez Díaz University Hospital, Universidad Autonoma de Madrid (IIS-FJD, UAM), 28040, Madrid, Spain.
Martin-Ruiz M; Health Research Institute-Fundación Jiménez Díaz University Hospital, Universidad Autonoma de Madrid (IIS-FJD, UAM), 28040, Madrid, Spain.
López-Guerrero JA; Molecular Biology department, Fundación Instituto Valenciano de Oncologia, 46009, Valencia, Spain.
Cruz J; Pathology department, Fundación Instituto Valenciano de Oncologia, 46009, Valencia, Spain.
Fernandez-Serra A; Molecular Biology department, Fundación Instituto Valenciano de Oncologia, 46009, Valencia, Spain.
Blay JY; Medicine Department, Centre Léon Bérard, 69008, Lyon, France.
Fumagalli E; Medicine Department, Fondazione IRCCS - Istituto Nazionale dei Tumori, 20133, Milan, Italy.
Martinez-Marin V; Department of Medical Oncology, Hospital Universitario La Paz-IdiPAZ, P. Castellana, 261, 28046, Madrid, Spain.
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Źródło:
Molecular cancer [Mol Cancer] 2023 Aug 09; Vol. 22 (1), pp. 127. Date of Electronic Publication: 2023 Aug 09.
Typ publikacji:
Clinical Trial, Phase II; Letter; Research Support, Non-U.S. Gov't
MeSH Terms:
Antineoplastic Agents*/therapeutic use
Gastrointestinal Stromal Tumors*/drug therapy
Gastrointestinal Stromal Tumors*/genetics
Sarcoma*/drug therapy
Adult ; Humans ; Mutation ; Protein Kinase Inhibitors/therapeutic use ; Proto-Oncogene Proteins c-kit/genetics
Raport

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