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Tytuł:
In vivo hematopoietic stem cell modification by mRNA delivery.
Autorzy:
Breda L; Department of Pediatrics, Hematology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Papp TE; Division of Infectious Diseases, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Triebwasser MP; Department of Pediatrics, Hematology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Department of Pediatrics, The University of Michigan, Ann Arbor, MI, USA.
Yadegari A; Division of Infectious Diseases, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Fedorky MT; Department of Pediatrics, Hematology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Tanaka N; Department of Pediatrics, Hematology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Abdulmalik O; Department of Pediatrics, Hematology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Pavani G; Department of Pathology and Laboratory Medicine, Center for Cellular and Molecular Therapeutics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Wang Y; Department of Pathology and Laboratory Medicine, Transfusion Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Department of Clinical Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
Grupp SA; Division of Oncology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Departments of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Chou ST; Department of Pediatrics, Hematology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Department of Pathology and Laboratory Medicine, Transfusion Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Ni H; Division of Infectious Diseases, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Mui BL; Acuitas Therapeutics, Vancouver, BC V6T1Z3, Canada.
Tam YK; Acuitas Therapeutics, Vancouver, BC V6T1Z3, Canada.
Weissman D; Division of Infectious Diseases, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Rivella S; Department of Pediatrics, Hematology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, USA.; Cell and Molecular Biology affinity group, University of Pennsylvania, Philadelphia, PA, USA.; Raymond G. Perelman Center for Cellular and Molecular Therapeutics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Penn Center for Musculoskeletal Disorders, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Penn Institute for RNA Innovation, University of Pennsylvania, Philadelphia, PA, USA.
Parhiz H; Division of Infectious Diseases, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
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Źródło:
Science (New York, N.Y.) [Science] 2023 Jul 28; Vol. 381 (6656), pp. 436-443. Date of Electronic Publication: 2023 Jul 27.
Typ publikacji:
Journal Article
MeSH Terms:
Gene Editing*/methods
Hematopoietic Stem Cells*/metabolism
Proto-Oncogene Proteins c-kit*/genetics
RNA, Messenger*/genetics
Hematopoietic Stem Cell Transplantation ; Animals ; Humans ; Mice
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Compensatory gene expression potentially rescues impaired brain development in Kit mutant mice.
Autorzy:
Minei R; Department of Bio-Science, Nagahama Institute of Bio-Science and Technology, Shiga, Japan.
Aoki H; Department of Tissue and Organ Development, Regeneration, and Advanced Medical Science, Graduate School of Medicine, Gifu University, 1-1 Yanagido, Gifu, 501-1194, Japan.
Ogura A; Department of Bio-Science, Nagahama Institute of Bio-Science and Technology, Shiga, Japan.
Kunisada T; Department of Tissue and Organ Development, Regeneration, and Advanced Medical Science, Graduate School of Medicine, Gifu University, 1-1 Yanagido, Gifu, 501-1194, Japan. .
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Źródło:
Scientific reports [Sci Rep] 2023 Mar 13; Vol. 13 (1), pp. 4166. Date of Electronic Publication: 2023 Mar 13.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Brain*/growth & development
Proto-Oncogene Proteins c-kit*/genetics
Proto-Oncogene Proteins c-kit*/metabolism
Animals ; Mice ; Gene Expression ; Mice, Mutant Strains ; Mutation ; Phenotype
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Chinese Pedigree with Hereditary Gastrointestinal Stromal Tumors: A Case Report and Literature Review.
Autorzy:
Ge Q; Department of Gastroenterology, Shengjing Hospital of China Medical University, 36 Sanhao Street, Shenyang 110004, China.; Innovative Research Center for Integrated Cancer Omics, Shengjing Hospital of China Medical University, Shenyang 110004, China.
Liu Y; Department of Gastroenterology, Shengjing Hospital of China Medical University, 36 Sanhao Street, Shenyang 110004, China.; Innovative Research Center for Integrated Cancer Omics, Shengjing Hospital of China Medical University, Shenyang 110004, China.
Yang F; Department of Gastroenterology, Shengjing Hospital of China Medical University, 36 Sanhao Street, Shenyang 110004, China.
Sun G; Innovative Engineering Technology Research Center for Cell Therapy, Shengjing Hospital of China Medical University, Shenyang 110022, China.
Guo J; Department of Gastroenterology, Shengjing Hospital of China Medical University, 36 Sanhao Street, Shenyang 110004, China.
Sun S; Department of Gastroenterology, Shengjing Hospital of China Medical University, 36 Sanhao Street, Shenyang 110004, China.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Jan 03; Vol. 24 (1). Date of Electronic Publication: 2023 Jan 03.
Typ publikacji:
Review; Case Reports
MeSH Terms:
Drug Resistance, Neoplasm*/genetics
Gastrointestinal Neoplasms*/drug therapy
Gastrointestinal Neoplasms*/genetics
Gastrointestinal Stromal Tumors*/drug therapy
Gastrointestinal Stromal Tumors*/genetics
Neoplastic Syndromes, Hereditary*/drug therapy
Neoplastic Syndromes, Hereditary*/genetics
Proto-Oncogene Proteins c-kit*/genetics
Humans ; Male ; Middle Aged ; Hyperpigmentation/genetics ; Mutation ; Pedigree ; China
Recenzja
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Meteorin-like promotes heart repair through endothelial KIT receptor tyrosine kinase.
Autorzy:
Reboll MR; Division of Molecular and Translational Cardiology, Hans Borst Center for Heart and Stem Cell Research, Hannover Medical School, 30625 Hannover, Germany.; Department of Cardiology and Angiology, Hannover Medical School, 30625 Hannover, Germany.
Klede S; Division of Molecular and Translational Cardiology, Hans Borst Center for Heart and Stem Cell Research, Hannover Medical School, 30625 Hannover, Germany.; Department of Cardiology and Angiology, Hannover Medical School, 30625 Hannover, Germany.
Taft MH; Institute for Biophysical Chemistry, Hannover Medical School, 30625 Hannover, Germany.
Cai CL; Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Field LJ; Krannert Cardiovascular Research Center and the Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Lavine KJ; Center for Cardiovascular Research, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Koenig AL; Center for Cardiovascular Research, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Fleischauer J; Institute of Experimental Hematology, Hannover Medical School, 30625 Hannover, Germany.
Meyer J; Institute of Experimental Hematology, Hannover Medical School, 30625 Hannover, Germany.
Schambach A; Institute of Experimental Hematology, Hannover Medical School, 30625 Hannover, Germany.
Niessen HW; Department of Pathology and Department of Cardiac Surgery, Institute for Cardiovascular Research, Amsterdam University Medical Center, 1007 MB Amsterdam, Netherlands.
Kosanke M; Research Core Unit Genomics, Hannover Medical School, 30625 Hannover, Germany.
van den Heuvel J; Technology Platform Recombinant Protein Expression, Helmholtz Center for Infection Research, 38124 Braunschweig, Germany.
Pich A; Core Unit Proteomics and Institute of Toxicology, Hannover Medical School, 30625 Hannover, Germany.
Bauersachs J; Department of Cardiology and Angiology, Hannover Medical School, 30625 Hannover, Germany.
Wu X; Division of Molecular and Translational Cardiology, Hans Borst Center for Heart and Stem Cell Research, Hannover Medical School, 30625 Hannover, Germany.; Department of Cardiology and Angiology, Hannover Medical School, 30625 Hannover, Germany.
Zheng L; Division of Molecular and Translational Cardiology, Hans Borst Center for Heart and Stem Cell Research, Hannover Medical School, 30625 Hannover, Germany.; Department of Cardiology and Angiology, Hannover Medical School, 30625 Hannover, Germany.
Wang Y; Division of Molecular and Translational Cardiology, Hans Borst Center for Heart and Stem Cell Research, Hannover Medical School, 30625 Hannover, Germany.; Department of Cardiology and Angiology, Hannover Medical School, 30625 Hannover, Germany.
Korf-Klingebiel M; Division of Molecular and Translational Cardiology, Hans Borst Center for Heart and Stem Cell Research, Hannover Medical School, 30625 Hannover, Germany.; Department of Cardiology and Angiology, Hannover Medical School, 30625 Hannover, Germany.
Polten F; Division of Molecular and Translational Cardiology, Hans Borst Center for Heart and Stem Cell Research, Hannover Medical School, 30625 Hannover, Germany.; Department of Cardiology and Angiology, Hannover Medical School, 30625 Hannover, Germany.
Wollert KC; Division of Molecular and Translational Cardiology, Hans Borst Center for Heart and Stem Cell Research, Hannover Medical School, 30625 Hannover, Germany.; Department of Cardiology and Angiology, Hannover Medical School, 30625 Hannover, Germany.
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Źródło:
Science (New York, N.Y.) [Science] 2022 Jun 17; Vol. 376 (6599), pp. 1343-1347. Date of Electronic Publication: 2022 Jun 16.
Typ publikacji:
Journal Article
MeSH Terms:
Adipokines*
Cytokines*/genetics
Cytokines*/metabolism
Myocardial Infarction*/complications
Myocardial Infarction*/physiopathology
Neovascularization, Physiologic*
Nerve Growth Factors*/genetics
Nerve Growth Factors*/metabolism
Proto-Oncogene Proteins c-kit*/metabolism
Animals ; Cells, Cultured ; Endothelial Cells/metabolism ; Heart Failure/etiology ; Heart Failure/genetics ; Ligands ; Macrophages/metabolism ; Mice ; Mice, Mutant Strains
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
C-KIT Expression in Orbital Cavernous Venous Hemangiomas.
Autorzy:
Atallah M; Ophthalmology Department, Emek Medical Center, Afula 18101, Israel.; Laboratory of Ophthalmic Research, Emek Medical Center, Afula 18101, Israel.
Edison N; The Tissue Diagnostics and Cancer Research Institute, Emek Medical Center, Afula 18101, Israel.
Levi E; Laboratory of Ophthalmic Research, Emek Medical Center, Afula 18101, Israel.
Elmalah I; The Tissue Diagnostics and Cancer Research Institute, Emek Medical Center, Afula 18101, Israel.
Briscoe D; Ophthalmology Department, Emek Medical Center, Afula 18101, Israel.; Laboratory of Ophthalmic Research, Emek Medical Center, Afula 18101, Israel.
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Źródło:
Biomolecules [Biomolecules] 2021 Aug 12; Vol. 11 (8). Date of Electronic Publication: 2021 Aug 12.
Typ publikacji:
Journal Article
MeSH Terms:
Gene Expression Regulation, Neoplastic*
Hemangioma, Cavernous/*metabolism
Orbital Neoplasms/*metabolism
Proto-Oncogene Proteins c-kit/*biosynthesis
Adolescent ; Adult ; Aged ; Child ; Female ; Hemangioma, Cavernous/genetics ; Hemangioma, Cavernous/pathology ; Humans ; Male ; Middle Aged ; Orbital Neoplasms/genetics ; Orbital Neoplasms/pathology ; Proto-Oncogene Proteins c-kit/genetics ; Young Adult
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Co-occurrence of KIT and NRAS mutations defines an adverse prognostic core-binding factor acute myeloid leukemia.
Autorzy:
Jin H; Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, China.; Key Laboratory of Hematology, Nanjing Medical University, Nanjing, China.; Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University, Nanjing, China.
Zhu Y; Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, China.; Key Laboratory of Hematology, Nanjing Medical University, Nanjing, China.; Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University, Nanjing, China.
Hong M; Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, China.; Key Laboratory of Hematology, Nanjing Medical University, Nanjing, China.; Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University, Nanjing, China.
Wu Y; Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, China.; Key Laboratory of Hematology, Nanjing Medical University, Nanjing, China.; Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University, Nanjing, China.
Qiu H; Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, China.; Key Laboratory of Hematology, Nanjing Medical University, Nanjing, China.; Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University, Nanjing, China.
Wang R; Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, China.; Key Laboratory of Hematology, Nanjing Medical University, Nanjing, China.; Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University, Nanjing, China.
Jin H; Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, China.; Key Laboratory of Hematology, Nanjing Medical University, Nanjing, China.; Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University, Nanjing, China.
Sun Q; Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, China.; Key Laboratory of Hematology, Nanjing Medical University, Nanjing, China.; Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University, Nanjing, China.
Fu J; Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, China.; Key Laboratory of Hematology, Nanjing Medical University, Nanjing, China.; Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University, Nanjing, China.
Li J; Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, China.; Key Laboratory of Hematology, Nanjing Medical University, Nanjing, China.; Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University, Nanjing, China.
Qian S; Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, China.; Key Laboratory of Hematology, Nanjing Medical University, Nanjing, China.; Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University, Nanjing, China.
Qiao C; Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, China.; Key Laboratory of Hematology, Nanjing Medical University, Nanjing, China.; Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University, Nanjing, China.
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Źródło:
Leukemia & lymphoma [Leuk Lymphoma] 2021 Oct; Vol. 62 (10), pp. 2428-2437. Date of Electronic Publication: 2021 May 24.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Leukemia, Myeloid, Acute*/diagnosis
Leukemia, Myeloid, Acute*/genetics
Proto-Oncogene Proteins c-kit*/genetics
Aged ; Core Binding Factors/genetics ; GTP Phosphohydrolases/genetics ; Humans ; Membrane Proteins/genetics ; Middle Aged ; Mutation ; Prognosis ; Retrospective Studies
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The pathogenic role of c-Kit+ mast cells in the spinal motor neuron-vascular niche in ALS.
Autorzy:
Kovacs M; Institut Pasteur de Montevideo, 2020, Montevideo, Uruguay.
Alamón C; Institut Pasteur de Montevideo, 2020, Montevideo, Uruguay.
Maciel C; Institut Pasteur de Montevideo, 2020, Montevideo, Uruguay.
Varela V; Institut Pasteur de Montevideo, 2020, Montevideo, Uruguay.
Ibarburu S; Institut Pasteur de Montevideo, 2020, Montevideo, Uruguay.
Tarragó L; Institut Pasteur de Montevideo, 2020, Montevideo, Uruguay.
King PH; Department of Neurology, University of Alabama, Birmingham, AL, 35294, USA.; Birmingham Veterans Affairs Medical Center, Birmingham, AL, 35295, USA.
Si Y; Department of Neurology, University of Alabama, Birmingham, AL, 35294, USA.; Birmingham Veterans Affairs Medical Center, Birmingham, AL, 35295, USA.
Kwon Y; Department of Neurology, University of Alabama, Birmingham, AL, 35294, USA.
Hermine O; Imagine Institute, Hôpital Necker, Paris, France.; INSERM UMR 1163, Laboratory of Cellular and Molecular Mechanisms of Hematological Disorders and Therapeutic Implications, Paris, France.; Imagine Institute, Paris Descartes-Sorbonne Paris Cité University, Paris, France.; CNRS ERL 8254, Paris, France.; Laboratory of Excellence GR-Ex, Paris, France.; Equipe Labélisée par la Ligue Nationale contre le cancer; AB Science; Department of Hematology, Necker Hospital, Paris, France.; Centre national de référence des mastocytoses (CEREMAST), Paris, France.
Barbeito L; Institut Pasteur de Montevideo, 2020, Montevideo, Uruguay.
Trias E; Institut Pasteur de Montevideo, 2020, Montevideo, Uruguay. .
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Źródło:
Acta neuropathologica communications [Acta Neuropathol Commun] 2021 Aug 13; Vol. 9 (1), pp. 136. Date of Electronic Publication: 2021 Aug 13.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Amyotrophic Lateral Sclerosis/*immunology
Mast Cells/*immunology
Microvessels/*pathology
Motor Neurons/*pathology
Neuroinflammatory Diseases/*immunology
Proto-Oncogene Proteins c-kit/*metabolism
Spinal Cord/*immunology
Aged ; Aged, 80 and over ; Amyotrophic Lateral Sclerosis/metabolism ; Amyotrophic Lateral Sclerosis/pathology ; Animals ; Astrocytes/metabolism ; Astrocytes/pathology ; Benzamides/pharmacology ; Case-Control Studies ; Chymases/metabolism ; Cyclooxygenase 2/metabolism ; Female ; Humans ; Male ; Mast Cells/drug effects ; Mast Cells/metabolism ; Mice ; Microvessels/metabolism ; Middle Aged ; Motor Neurons/metabolism ; Neuroinflammatory Diseases/metabolism ; Neuroinflammatory Diseases/pathology ; Piperidines/pharmacology ; Protein Kinase Inhibitors/pharmacology ; Proto-Oncogene Proteins c-kit/antagonists & inhibitors ; Pyridines/pharmacology ; Spinal Cord/drug effects ; Spinal Cord/metabolism ; Spinal Cord/pathology ; Stem Cell Factor/metabolism ; Thiazoles/pharmacology ; Tryptases/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Fe Metallohelices Stabilize DNA G-Quadruplexes and Downregulate the Expression of G-Quadruplex-Regulated Oncogenes.
Autorzy:
Malina J; Institute of Biophysics, Czech Academy of Sciences, Kralovopolska 135, 61265, Brno, Czech Republic.
Kostrhunova H; Institute of Biophysics, Czech Academy of Sciences, Kralovopolska 135, 61265, Brno, Czech Republic.
Scott P; Department of Chemistry, University of Warwick, Coventry, CV4 7AL, UK.
Brabec V; Institute of Biophysics, Czech Academy of Sciences, Kralovopolska 135, 61265, Brno, Czech Republic.
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Źródło:
Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2021 Aug 11; Vol. 27 (45), pp. 11682-11692. Date of Electronic Publication: 2021 Jun 28.
Typ publikacji:
Journal Article
MeSH Terms:
G-Quadruplexes*
Proto-Oncogene Proteins c-kit*/genetics
Proto-Oncogene Proteins c-myc*/genetics
DNA ; Ferrous Compounds ; Humans ; Telomere
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Evolution of KIPPIS as a versatile platform for evaluating intracellularly functional peptide aptamers.
Autorzy:
Kashima D; Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8656, Japan.
Kawahara M; Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8656, Japan. .; Laboratory of Cell Vaccine, Center for Vaccine and Adjuvant Research (CVAR), National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN), 7-6-8 Saito-Asagi, Ibaraki-shi, Osaka, 567-0085, Japan. .
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Źródło:
Scientific reports [Sci Rep] 2021 Jun 03; Vol. 11 (1), pp. 11758. Date of Electronic Publication: 2021 Jun 03.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Aptamers, Peptide/*metabolism
Protein Interaction Mapping/*methods
Proto-Oncogene Proteins c-kit/*metabolism
Aptamers, Peptide/chemistry ; Humans ; Ligands ; Peptides/chemistry ; Peptides/metabolism ; Protein Binding ; Protein Engineering/methods ; Proto-Oncogene Proteins c-kit/chemistry
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Setd4 controlled quiescent c-Kit cells contribute to cardiac neovascularization of capillaries beyond activation.
Autorzy:
Xing S; MOE Laboratory of Biosystem Homeostasis and Protection, College of Life, Sciences, Zhejiang University, Hangzhou, 310058, China.
Tian JZ; MOE Laboratory of Biosystem Homeostasis and Protection, College of Life, Sciences, Zhejiang University, Hangzhou, 310058, China.
Yang SH; MOE Laboratory of Biosystem Homeostasis and Protection, College of Life, Sciences, Zhejiang University, Hangzhou, 310058, China.
Huang XT; MOE Laboratory of Biosystem Homeostasis and Protection, College of Life, Sciences, Zhejiang University, Hangzhou, 310058, China.
Ding YF; MOE Laboratory of Biosystem Homeostasis and Protection, College of Life, Sciences, Zhejiang University, Hangzhou, 310058, China.
Lu QY; MOE Laboratory of Biosystem Homeostasis and Protection, College of Life, Sciences, Zhejiang University, Hangzhou, 310058, China.
Yang JS; MOE Laboratory of Biosystem Homeostasis and Protection, College of Life, Sciences, Zhejiang University, Hangzhou, 310058, China.
Yang WJ; MOE Laboratory of Biosystem Homeostasis and Protection, College of Life, Sciences, Zhejiang University, Hangzhou, 310058, China. w_.
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Źródło:
Scientific reports [Sci Rep] 2021 Jun 02; Vol. 11 (1), pp. 11603. Date of Electronic Publication: 2021 Jun 02.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Epigenesis, Genetic*
Endothelial Cells/*metabolism
Methyltransferases/*genetics
Myocardial Infarction/*genetics
Myocytes, Cardiac/*metabolism
Proto-Oncogene Proteins c-kit/*genetics
Animals ; Apoptosis ; Capillaries/growth & development ; Cell Division ; Cell Proliferation ; Disease Models, Animal ; Echocardiography ; Endothelial Cells/cytology ; Female ; Histones/genetics ; Histones/metabolism ; Integrases/genetics ; Integrases/metabolism ; Methyltransferases/metabolism ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Myocardial Infarction/diagnostic imaging ; Myocardial Infarction/metabolism ; Myocardial Infarction/pathology ; Myocardium/metabolism ; Myocardium/pathology ; Myocytes, Cardiac/cytology ; Neovascularization, Physiologic ; Phosphatidylinositol 3-Kinases/genetics ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/genetics ; Proto-Oncogene Proteins c-akt/metabolism ; Proto-Oncogene Proteins c-kit/metabolism ; TOR Serine-Threonine Kinases/genetics ; TOR Serine-Threonine Kinases/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Adverse Prognostic Impact of the KIT D816V Transcriptional Activity in Advanced Systemic Mastocytosis.
Autorzy:
Naumann N; Department of Hematology and Oncology, University Hospital Mannheim, Heidelberg University, 68167 Mannheim, Germany.
Lübke J; Department of Hematology and Oncology, University Hospital Mannheim, Heidelberg University, 68167 Mannheim, Germany.
Baumann S; Department of Hematology and Oncology, University Hospital Mannheim, Heidelberg University, 68167 Mannheim, Germany.
Schwaab J; Department of Hematology and Oncology, University Hospital Mannheim, Heidelberg University, 68167 Mannheim, Germany.
Hoffmann O; Department of Hematology and Oncology, University Hospital Mannheim, Heidelberg University, 68167 Mannheim, Germany.
Kreil S; Department of Hematology and Oncology, University Hospital Mannheim, Heidelberg University, 68167 Mannheim, Germany.
Dangelo V; Department of Hematology and Oncology, University Hospital Mannheim, Heidelberg University, 68167 Mannheim, Germany.
Reiter L; Department of Hematology and Oncology, University Hospital Mannheim, Heidelberg University, 68167 Mannheim, Germany.
Bugert P; Institute of Transfusion Medicine and Immunology, University Hospital Mannheim, Heidelberg University, 68167 Mannheim, Germany.
Kristensen T; Mastocytosis Center, Odense University Hospital, 5000 Odense, Denmark.; Department of Pathology, Odense University Hospital, 5000 Odense, Denmark.
Sotlar K; University Hospital Salzburg, Paracelsus Medical University, 5020 Salzburg, Austria.
Haselmann V; Institute for Clinical Chemistry, University Hospital Mannheim, Heidelberg University, 68167 Mannheim, Germany.
Schneider S; Institute for Clinical Chemistry, University Hospital Mannheim, Heidelberg University, 68167 Mannheim, Germany.
Metzgeroth G; Department of Hematology and Oncology, University Hospital Mannheim, Heidelberg University, 68167 Mannheim, Germany.
Weiss C; Department of Medical Statistics and Biomathematics, University Hospital Mannheim, Heidelberg University, 68167 Mannheim, Germany.
Popp HD; Department of Hematology and Oncology, University Hospital Mannheim, Heidelberg University, 68167 Mannheim, Germany.
Fabarius A; Department of Hematology and Oncology, University Hospital Mannheim, Heidelberg University, 68167 Mannheim, Germany.
Hofmann WK; Department of Hematology and Oncology, University Hospital Mannheim, Heidelberg University, 68167 Mannheim, Germany.
Cross NCP; School of Medicine, University of Southampton, Southampton SO17 1BJ, UK.; Wessex Regional Genetics Laboratory, Salisbury SP2 8BJ, UK.
Reiter A; Department of Hematology and Oncology, University Hospital Mannheim, Heidelberg University, 68167 Mannheim, Germany.
Jawhar M; Department of Hematology and Oncology, University Hospital Mannheim, Heidelberg University, 68167 Mannheim, Germany.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Mar 04; Vol. 22 (5). Date of Electronic Publication: 2021 Mar 04.
Typ publikacji:
Journal Article
MeSH Terms:
Mutation*
Mastocytosis, Systemic/*genetics
Proto-Oncogene Proteins c-kit/*genetics
Adult ; Aged ; Aged, 80 and over ; Amino Acid Substitution ; Bone Marrow/metabolism ; DNA/blood ; DNA/genetics ; DNA/metabolism ; Female ; Gene Frequency ; Humans ; Male ; Mastocytosis, Systemic/blood ; Mastocytosis, Systemic/metabolism ; Middle Aged ; Phenotype ; Prognosis ; Proto-Oncogene Proteins c-kit/metabolism ; RNA/blood ; RNA/genetics ; RNA/metabolism ; Transcription, Genetic
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Molecular Modeling Study of c-KIT/PDGFRα Dual Inhibitors for the Treatment of Gastrointestinal Stromal Tumors.
Autorzy:
Keretsu S; Department of Biomedical Sciences, College of Medicine, Chosun University, Gwangju 501-759, Korea.
Ghosh S; Department of Biomedical Sciences, College of Medicine, Chosun University, Gwangju 501-759, Korea.
Cho SJ; Department of Biomedical Sciences, College of Medicine, Chosun University, Gwangju 501-759, Korea.; Department of Cellular Molecular Medicine, College of Medicine, Chosun University, Gwangju 501-759, Korea.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2020 Nov 03; Vol. 21 (21). Date of Electronic Publication: 2020 Nov 03.
Typ publikacji:
Journal Article
MeSH Terms:
Models, Molecular*
Gastrointestinal Neoplasms/*drug therapy
Gastrointestinal Stromal Tumors/*drug therapy
Protein Kinase Inhibitors/*isolation & purification
Proto-Oncogene Proteins c-kit/*antagonists & inhibitors
Receptor, Platelet-Derived Growth Factor alpha/*antagonists & inhibitors
Amino Acid Substitution ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/isolation & purification ; Antineoplastic Agents/pharmacokinetics ; Antineoplastic Agents/therapeutic use ; Binding Sites ; Drug Screening Assays, Antitumor/methods ; Humans ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Mutant Proteins/chemistry ; Mutant Proteins/genetics ; Mutant Proteins/metabolism ; Protein Kinase Inhibitors/chemistry ; Protein Kinase Inhibitors/pharmacokinetics ; Protein Kinase Inhibitors/therapeutic use ; Proto-Oncogene Proteins c-kit/chemistry ; Proto-Oncogene Proteins c-kit/genetics ; Proto-Oncogene Proteins c-kit/metabolism ; Pyrazoles/chemistry ; Pyridines/chemistry ; Quantitative Structure-Activity Relationship ; Receptor, Platelet-Derived Growth Factor alpha/chemistry ; Receptor, Platelet-Derived Growth Factor alpha/genetics ; Receptor, Platelet-Derived Growth Factor alpha/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
CD117/c-kit defines a prostate CSC-like subpopulation driving progression and TKI resistance.
Autorzy:
Harris KS; Department of Cancer Biology, Wake Forest School of Medicine, Medical Center Blvd, Winston-Salem, NC, 27157, USA.
Shi L; Department of Cancer Biology, Wake Forest School of Medicine, Medical Center Blvd, Winston-Salem, NC, 27157, USA.
Foster BM; Department of Cancer Biology, Wake Forest School of Medicine, Medical Center Blvd, Winston-Salem, NC, 27157, USA.
Mobley ME; Department of Cancer Biology, Wake Forest School of Medicine, Medical Center Blvd, Winston-Salem, NC, 27157, USA.
Elliott PL; Department of Cancer Biology, Wake Forest School of Medicine, Medical Center Blvd, Winston-Salem, NC, 27157, USA.
Song CJ; Department of Cancer Biology, Wake Forest School of Medicine, Medical Center Blvd, Winston-Salem, NC, 27157, USA.
Watabe K; Department of Cancer Biology, Wake Forest School of Medicine, Medical Center Blvd, Winston-Salem, NC, 27157, USA.; Wake Forest Baptist Comprehensive Cancer Center, Winston-Salem, NC, 27157, USA.
Langefeld CD; Wake Forest Baptist Comprehensive Cancer Center, Winston-Salem, NC, 27157, USA.; Department of Biostatistics and Data Science, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, 27157, USA.
Kerr BA; Department of Cancer Biology, Wake Forest School of Medicine, Medical Center Blvd, Winston-Salem, NC, 27157, USA. .; Wake Forest Baptist Comprehensive Cancer Center, Winston-Salem, NC, 27157, USA. .; Department of Urology, Wake Forest School of Medicine, Winston-Salem, NC, 27157, USA. .
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Źródło:
Scientific reports [Sci Rep] 2021 Jan 14; Vol. 11 (1), pp. 1465. Date of Electronic Publication: 2021 Jan 14.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Neoplastic Stem Cells/*metabolism
Prostatic Neoplasms/*metabolism
Proto-Oncogene Proteins c-kit/*immunology
Biomarkers, Tumor/metabolism ; Cell Line, Tumor ; Cell Proliferation ; Databases, Genetic ; Disease Progression ; Humans ; Male ; Neoplasm Grading ; Neoplasm Recurrence, Local/metabolism ; Neoplastic Stem Cells/physiology ; Prostate/pathology ; Prostatic Neoplasms/physiopathology ; Protein-Tyrosine Kinases/antagonists & inhibitors ; Proto-Oncogene Proteins c-kit/metabolism ; Stem Cell Factor/metabolism
Czasopismo naukowe
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Tytuł:
Clinical Impact of Inherited and Acquired Genetic Variants in Mastocytosis.
Autorzy:
Nedoszytko B; Department of Dermatology, Allergology and Venereology, Medical University of Gdansk, 80-211 Gdansk, Poland.
Arock M; Department of Hematology, APHP, Hôpital Pitié-Salpêtrière and Sorbonne University, 75013 Paris, France.; Centre de Recherche des Cordeliers, INSERM, Sorbonne Université, Université de Paris, Cell Death and Drug Resistance in Hematological Disorders Team, 75006 Paris, France.
Lyons JJ; Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-188, USA.
Bachelot G; Department of Hematology, APHP, Hôpital Pitié-Salpêtrière and Sorbonne University, 75013 Paris, France.
Schwartz LB; Department of Internal Medicine, Division of Rheumatology, Allergy & Immunology, Virginia Commonwealth University, Richmond, VA 23298, USA.
Reiter A; University Hospital Mannheim, Heidelberg University, 68167 Mannheim, Germany.
Jawhar M; University Hospital Mannheim, Heidelberg University, 68167 Mannheim, Germany.
Schwaab J; University Hospital Mannheim, Heidelberg University, 68167 Mannheim, Germany.
Lange M; Department of Dermatology, Allergology and Venereology, Medical University of Gdansk, 80-211 Gdansk, Poland.
Greiner G; Department of Laboratory Medicine, Medical University of Vienna, 1090 Vienna, Austria.; Ludwig Boltzmann Institute for Hematology and Oncology, Medical University of Vienna, 1090 Vienna, Austria.; Ihr Labor, Medical Diagnostic Laboratories, 1220 Vienna, Austria.
Hoermann G; Ludwig Boltzmann Institute for Hematology and Oncology, Medical University of Vienna, 1090 Vienna, Austria.; MLL Munich Leukemia Laboratory, 81377 Munich, Germany.
Niedoszytko M; Department of Allergology, Medical University of Gdansk, 80-211 Gdansk, Poland.
Metcalfe DD; Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-188, USA.
Valent P; Ludwig Boltzmann Institute for Hematology and Oncology, Medical University of Vienna, 1090 Vienna, Austria.; Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, 1090 Vienna, Austria.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Jan 02; Vol. 22 (1). Date of Electronic Publication: 2021 Jan 02.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Polymorphism, Genetic*
Cytokines/*genetics
Mastocytosis, Systemic/*genetics
Proto-Oncogene Proteins c-kit/*genetics
Toll-Like Receptor 2/*genetics
Humans ; Interleukin-13/genetics ; Interleukin-6/genetics ; Interleukins/genetics ; Mast Cells/pathology ; Mastocytosis, Systemic/diagnosis ; Mastocytosis, Systemic/metabolism ; Mastocytosis, Systemic/physiopathology ; Nerve Tissue Proteins/genetics ; Phospholipase C gamma/genetics ; Proto-Oncogene Proteins c-kit/metabolism ; Receptors, G-Protein-Coupled/genetics ; Receptors, Neuropeptide/genetics ; Toll-Like Receptor 2/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The Inherent Coupling of Intrinsically Disordered Regions in the Multidomain Receptor Tyrosine Kinase KIT.
Autorzy:
Ledoux J; Centre Borelli, ENS Paris-Saclay, CNRS, Université Paris-Saclay, 4 Avenue des Sciences, F-91190 Gif-sur-Yvette, France.
Trouvé A; Centre Borelli, ENS Paris-Saclay, CNRS, Université Paris-Saclay, 4 Avenue des Sciences, F-91190 Gif-sur-Yvette, France.
Tchertanov L; Centre Borelli, ENS Paris-Saclay, CNRS, Université Paris-Saclay, 4 Avenue des Sciences, F-91190 Gif-sur-Yvette, France.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Jan 29; Vol. 23 (3). Date of Electronic Publication: 2022 Jan 29.
Typ publikacji:
Journal Article
MeSH Terms:
Proto-Oncogene Proteins c-kit/*chemistry
Proto-Oncogene Proteins c-kit/*metabolism
Catalytic Domain ; Humans ; Hydrogen Bonding ; Models, Molecular ; Molecular Dynamics Simulation ; Protein Binding ; Protein Conformation ; Protein Domains ; Protein Folding ; Protein Interaction Maps
Czasopismo naukowe
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Tytuł:
Engineering Stem Cell Factor Ligands with Different c-Kit Agonistic Potencies.
Autorzy:
Tilayov T; Avram and Stella Goldstein-Goren Department of Biotechnology Engineering and the National Institute of Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel.
Hingaly T; Avram and Stella Goldstein-Goren Department of Biotechnology Engineering and the National Institute of Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel.
Greenshpan Y; Shraga Segal Department of Microbiology, Immunology and Genetics and the National Institute of Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel.
Cohen S; Department of Chemistry and the National Institute for Biotechnology in the Negev (NIBN), Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel.
Akabayov B; Department of Chemistry and the National Institute for Biotechnology in the Negev (NIBN), Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel.
Gazit R; Shraga Segal Department of Microbiology, Immunology and Genetics and the National Institute of Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel.
Papo N; Avram and Stella Goldstein-Goren Department of Biotechnology Engineering and the National Institute of Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2020 Oct 21; Vol. 25 (20). Date of Electronic Publication: 2020 Oct 21.
Typ publikacji:
Journal Article
MeSH Terms:
Proto-Oncogene Proteins c-kit/*agonists
Stem Cell Factor/*pharmacology
Cell Line, Tumor ; Humans ; Phosphorylation ; Proto-Oncogene Proteins c-kit/metabolism ; Stem Cell Factor/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Evidence supports white spotting in donkeys as a homozygous lethal condition.
Autorzy:
Tanaka J; Veterinary Genetics Laboratory, School of Veterinary Medicine, University of California, Davis, CA, 95616, USA.
Grahn R; Veterinary Genetics Laboratory, School of Veterinary Medicine, University of California, Davis, CA, 95616, USA.
Bellone RR; Veterinary Genetics Laboratory, School of Veterinary Medicine, University of California, Davis, CA, 95616, USA.; Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, CA, 95616, USA.
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Źródło:
Animal genetics [Anim Genet] 2020 Oct; Vol. 51 (5), pp. 840-842. Date of Electronic Publication: 2020 Jul 13.
Typ publikacji:
Journal Article
MeSH Terms:
Equidae/*physiology
Genes, Lethal/*genetics
Hair Color/*genetics
Proto-Oncogene Proteins c-kit/*genetics
Animals ; Equidae/genetics ; Genes, Recessive/genetics ; Homozygote ; Mutation ; Proto-Oncogene Proteins c-kit/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Pressure overload by suprarenal aortic constriction in mice leads to left ventricular hypertrophy without c-Kit expression in cardiomyocytes.
Autorzy:
Nicks AM; Division of Molecular Cardiology and Biophysics, Victor Chang Cardiac Research Institute, 405 Liverpool Street, Darlinghurst, Sydney, NSW, 2010, Australia.; St Vincent's Clinical School, University of New South Wales, Sydney, NSW, 2052, Australia.
Kesteven SH; Division of Molecular Cardiology and Biophysics, Victor Chang Cardiac Research Institute, 405 Liverpool Street, Darlinghurst, Sydney, NSW, 2010, Australia.; St Vincent's Clinical School, University of New South Wales, Sydney, NSW, 2052, Australia.
Li M; Division of Molecular Cardiology and Biophysics, Victor Chang Cardiac Research Institute, 405 Liverpool Street, Darlinghurst, Sydney, NSW, 2010, Australia.; Cardiac Regeneration Research Institute, Wenzhou Medical University, Wenzhou, 325035, China.
Wu J; Division of Molecular Cardiology and Biophysics, Victor Chang Cardiac Research Institute, 405 Liverpool Street, Darlinghurst, Sydney, NSW, 2010, Australia.
Chan AY; Division of Molecular Cardiology and Biophysics, Victor Chang Cardiac Research Institute, 405 Liverpool Street, Darlinghurst, Sydney, NSW, 2010, Australia.
Naqvi N; Department of Medicine, Emory University, Atlanta, GA, 30322, USA.
Husain A; Department of Medicine, Emory University, Atlanta, GA, 30322, USA.
Feneley MP; Division of Molecular Cardiology and Biophysics, Victor Chang Cardiac Research Institute, 405 Liverpool Street, Darlinghurst, Sydney, NSW, 2010, Australia.; St Vincent's Clinical School, University of New South Wales, Sydney, NSW, 2052, Australia.
Smith NJ; Division of Molecular Cardiology and Biophysics, Victor Chang Cardiac Research Institute, 405 Liverpool Street, Darlinghurst, Sydney, NSW, 2010, Australia.; St Vincent's Clinical School, University of New South Wales, Sydney, NSW, 2052, Australia.
Iismaa SE; Division of Molecular Cardiology and Biophysics, Victor Chang Cardiac Research Institute, 405 Liverpool Street, Darlinghurst, Sydney, NSW, 2010, Australia.; St Vincent's Clinical School, University of New South Wales, Sydney, NSW, 2052, Australia.
Graham RM; Division of Molecular Cardiology and Biophysics, Victor Chang Cardiac Research Institute, 405 Liverpool Street, Darlinghurst, Sydney, NSW, 2010, Australia. .; St Vincent's Clinical School, University of New South Wales, Sydney, NSW, 2052, Australia. .
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Źródło:
Scientific reports [Sci Rep] 2020 Sep 18; Vol. 10 (1), pp. 15318. Date of Electronic Publication: 2020 Sep 18.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Hypertrophy, Left Ventricular/*pathology
Myocytes, Cardiac/*pathology
Proto-Oncogene Proteins c-kit/*metabolism
Animals ; Aorta/physiopathology ; Constriction, Pathologic ; Gene Expression Regulation ; Hypertension/etiology ; Hypertension/physiopathology ; Hypertrophy, Left Ventricular/genetics ; Male ; Mice, Inbred C57BL ; Mice, Transgenic ; Pressure ; Proto-Oncogene Proteins c-kit/genetics ; Renal Circulation ; Renin/genetics ; Ventricular Dysfunction, Left/genetics ; Ventricular Dysfunction, Left/physiopathology ; Ventricular Remodeling/genetics ; Ventricular Remodeling/physiology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Piebaldism resulting from a novel deletion mutation of KIT gene in a five-generation Chinese family.
Autorzy:
Chen YJ; Department of Dermatology and Venereology, West China Hospital, Sichuan University, Chengdu, China.
Diao P; Department of Dermatology and Venereology, West China Hospital, Sichuan University, Chengdu, China.
Wan RY; Department of Dermatology and Venereology, West China Hospital, Sichuan University, Chengdu, China.
Li L; Department of Dermatology and Venereology, West China Hospital, Sichuan University, Chengdu, China.
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Źródło:
Clinical and experimental dermatology [Clin Exp Dermatol] 2022 Jan; Vol. 47 (1), pp. 232-234. Date of Electronic Publication: 2021 Aug 10.
Typ publikacji:
Case Reports; Journal Article
MeSH Terms:
Sequence Deletion*
Piebaldism/*genetics
Proto-Oncogene Proteins c-kit/*genetics
Asian People/genetics ; Female ; Humans ; Infant ; Pedigree
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Colour-sidedness in Gloucester cattle is associated with a complex structural variant impacting regulatory elements downstream of KIT.
Autorzy:
Artesi M; Unit of Animal Genomics, GIGA Institute, University of Liège, 1, avenue de l'hôpital, Liège, 4000, Belgium.
Tamma N; Unit of Animal Genomics, GIGA Institute, University of Liège, 1, avenue de l'hôpital, Liège, 4000, Belgium.
Deckers M; Unit of Animal Genomics, GIGA Institute, University of Liège, 1, avenue de l'hôpital, Liège, 4000, Belgium.
Karim L; Unit of Animal Genomics, GIGA Institute, University of Liège, 1, avenue de l'hôpital, Liège, 4000, Belgium.
Coppieters W; Unit of Animal Genomics, GIGA Institute, University of Liège, 1, avenue de l'hôpital, Liège, 4000, Belgium.
Van den Broeke A; Unit of Animal Genomics, GIGA Institute, University of Liège, 1, avenue de l'hôpital, Liège, 4000, Belgium.; Laboratory of Experimental Hematology, Institut Jules Bordet, Université Libre de Bruxelles, Boulevard de Waterloo 121, Brussels, 1000, Belgium.
Georges M; Unit of Animal Genomics, GIGA Institute, University of Liège, 1, avenue de l'hôpital, Liège, 4000, Belgium.
Charlier C; Unit of Animal Genomics, GIGA Institute, University of Liège, 1, avenue de l'hôpital, Liège, 4000, Belgium.
Durkin K; Unit of Animal Genomics, GIGA Institute, University of Liège, 1, avenue de l'hôpital, Liège, 4000, Belgium.
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Źródło:
Animal genetics [Anim Genet] 2020 Jun; Vol. 51 (3), pp. 461-465. Date of Electronic Publication: 2020 Apr 12.
Typ publikacji:
Journal Article
MeSH Terms:
Phenotype*
Regulatory Sequences, Nucleic Acid*
Cattle/*physiology
Hair Color/*genetics
Proto-Oncogene Proteins c-kit/*genetics
Animals ; Belgium ; Cattle/genetics ; Male ; Proto-Oncogene Proteins c-kit/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
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