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Wyszukujesz frazę ""c-Kit"" wg kryterium: Temat


Tytuł :
A new monoclonal antibody that blocks dimerisation and inhibits c-kit mutation-driven tumour growth.
Autorzy :
Bai C; Department of Pathology, Changhai Hospital, Second Military Medical University, Shanghai, China.
Xu Y; Department of Pathology, Yueyang Integrative Medicine Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Qiu C; Department of Pathology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Number 639 Zhizaoju Rd., Shanghai, 200001, China. .
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Źródło :
Journal of cancer research and clinical oncology [J Cancer Res Clin Oncol] 2021 Apr; Vol. 147 (4), pp. 1065-1075. Date of Electronic Publication: 2021 Jan 03.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Expression Regulation, Neoplastic*
Mutation*
Protein Multimerization*
Antibodies, Monoclonal/*pharmacology
Biomarkers, Tumor/*metabolism
Neoplasms/*pathology
Proto-Oncogene Proteins c-kit/*metabolism
Apoptosis ; Biomarkers, Tumor/genetics ; Cell Cycle ; Cell Proliferation ; Humans ; Neoplasms/genetics ; Neoplasms/immunology ; Neoplasms/metabolism ; Proto-Oncogene Proteins c-kit/chemistry ; Proto-Oncogene Proteins c-kit/genetics ; Proto-Oncogene Proteins c-kit/immunology ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
Comparison of Repeated Doses of C-kit-Positive Cardiac Cells versus a Single Equivalent Combined Dose in a Murine Model of Chronic Ischemic Cardiomyopathy.
Autorzy :
Li Q; Division of Cardiovascular Medicine, Institute of Molecular Cardiology, University of Louisville, Louisville, KY 40292, USA.
Guo Y; Division of Cardiovascular Medicine, Institute of Molecular Cardiology, University of Louisville, Louisville, KY 40292, USA.
Nong Y; Division of Cardiovascular Medicine, Institute of Molecular Cardiology, University of Louisville, Louisville, KY 40292, USA.
Tomlin A; Division of Cardiovascular Medicine, Institute of Molecular Cardiology, University of Louisville, Louisville, KY 40292, USA.
Gumpert A; Division of Cardiovascular Medicine, Institute of Molecular Cardiology, University of Louisville, Louisville, KY 40292, USA.
Zhu X; Division of Cardiovascular Medicine, Institute of Molecular Cardiology, University of Louisville, Louisville, KY 40292, USA.
Hassan SA; Division of Cardiovascular Medicine, Institute of Molecular Cardiology, University of Louisville, Louisville, KY 40292, USA.
Bolli R; Division of Cardiovascular Medicine, Institute of Molecular Cardiology, University of Louisville, Louisville, KY 40292, USA.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Mar 19; Vol. 22 (6). Date of Electronic Publication: 2021 Mar 19.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Dosage*
Cardiomyopathies/*etiology
Myocardial Ischemia/*complications
Myocytes, Cardiac/*metabolism
Proto-Oncogene Proteins c-kit/*genetics
Animals ; Biomarkers ; Biopsy ; Body Weights and Measures ; Cardiomyopathies/diagnosis ; Cardiomyopathies/metabolism ; Cardiomyopathies/therapy ; Cells, Cultured ; Disease Models, Animal ; Echocardiography ; Fibrosis ; Heart Function Tests ; Hemodynamics ; Hypertrophy, Left Ventricular/etiology ; Hypertrophy, Left Ventricular/metabolism ; Hypertrophy, Left Ventricular/pathology ; Mice ; Myocardial Infarction/etiology ; Myocardial Infarction/metabolism ; Myocardial Infarction/pathology ; Myocardial Ischemia/etiology ; Proto-Oncogene Proteins c-kit/metabolism
Czasopismo naukowe
Tytuł :
Adverse Prognostic Impact of the KIT D816V Transcriptional Activity in Advanced Systemic Mastocytosis.
Autorzy :
Naumann N; Department of Hematology and Oncology, University Hospital Mannheim, Heidelberg University, 68167 Mannheim, Germany.
Lübke J; Department of Hematology and Oncology, University Hospital Mannheim, Heidelberg University, 68167 Mannheim, Germany.
Baumann S; Department of Hematology and Oncology, University Hospital Mannheim, Heidelberg University, 68167 Mannheim, Germany.
Schwaab J; Department of Hematology and Oncology, University Hospital Mannheim, Heidelberg University, 68167 Mannheim, Germany.
Hoffmann O; Department of Hematology and Oncology, University Hospital Mannheim, Heidelberg University, 68167 Mannheim, Germany.
Kreil S; Department of Hematology and Oncology, University Hospital Mannheim, Heidelberg University, 68167 Mannheim, Germany.
Dangelo V; Department of Hematology and Oncology, University Hospital Mannheim, Heidelberg University, 68167 Mannheim, Germany.
Reiter L; Department of Hematology and Oncology, University Hospital Mannheim, Heidelberg University, 68167 Mannheim, Germany.
Bugert P; Institute of Transfusion Medicine and Immunology, University Hospital Mannheim, Heidelberg University, 68167 Mannheim, Germany.
Kristensen T; Mastocytosis Center, Odense University Hospital, 5000 Odense, Denmark.; Department of Pathology, Odense University Hospital, 5000 Odense, Denmark.
Sotlar K; University Hospital Salzburg, Paracelsus Medical University, 5020 Salzburg, Austria.
Haselmann V; Institute for Clinical Chemistry, University Hospital Mannheim, Heidelberg University, 68167 Mannheim, Germany.
Schneider S; Institute for Clinical Chemistry, University Hospital Mannheim, Heidelberg University, 68167 Mannheim, Germany.
Metzgeroth G; Department of Hematology and Oncology, University Hospital Mannheim, Heidelberg University, 68167 Mannheim, Germany.
Weiss C; Department of Medical Statistics and Biomathematics, University Hospital Mannheim, Heidelberg University, 68167 Mannheim, Germany.
Popp HD; Department of Hematology and Oncology, University Hospital Mannheim, Heidelberg University, 68167 Mannheim, Germany.
Fabarius A; Department of Hematology and Oncology, University Hospital Mannheim, Heidelberg University, 68167 Mannheim, Germany.
Hofmann WK; Department of Hematology and Oncology, University Hospital Mannheim, Heidelberg University, 68167 Mannheim, Germany.
Cross NCP; School of Medicine, University of Southampton, Southampton SO17 1BJ, UK.; Wessex Regional Genetics Laboratory, Salisbury SP2 8BJ, UK.
Reiter A; Department of Hematology and Oncology, University Hospital Mannheim, Heidelberg University, 68167 Mannheim, Germany.
Jawhar M; Department of Hematology and Oncology, University Hospital Mannheim, Heidelberg University, 68167 Mannheim, Germany.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Mar 04; Vol. 22 (5). Date of Electronic Publication: 2021 Mar 04.
Typ publikacji :
Journal Article
MeSH Terms :
Mutation*
Mastocytosis, Systemic/*genetics
Proto-Oncogene Proteins c-kit/*genetics
Adult ; Aged ; Aged, 80 and over ; Amino Acid Substitution ; Bone Marrow/metabolism ; DNA/blood ; DNA/genetics ; DNA/metabolism ; Female ; Gene Frequency ; Humans ; Male ; Mastocytosis, Systemic/blood ; Mastocytosis, Systemic/metabolism ; Middle Aged ; Phenotype ; Prognosis ; Proto-Oncogene Proteins c-kit/metabolism ; RNA/blood ; RNA/genetics ; RNA/metabolism ; Transcription, Genetic
Czasopismo naukowe
Tytuł :
Catching the clinical and biological diversity for an appropriate therapeutic approach in systemic mastocytosis.
Autorzy :
Mannelli F; CRIMM, Centro di Ricerca e Innovazione per le Malattie Mieloproliferative, SOD Ematologia, Azienda Ospedaliera Universitaria Careggi, Largo Brambilla 3, 50134, Firenze, Italy. .
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Źródło :
Annals of hematology [Ann Hematol] 2021 Feb; Vol. 100 (2), pp. 337-344. Date of Electronic Publication: 2020 Nov 06.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Cladribine/*therapeutic use
Interferons/*therapeutic use
Mastocytosis, Systemic/*drug therapy
Proto-Oncogene Proteins c-kit/*antagonists & inhibitors
Humans ; Mast Cells/metabolism ; Mast Cells/pathology ; Mastocytosis, Systemic/metabolism ; Mastocytosis, Systemic/pathology ; Proto-Oncogene Proteins c-kit/metabolism
Czasopismo naukowe
Tytuł :
Clinical Impact of Inherited and Acquired Genetic Variants in Mastocytosis.
Autorzy :
Nedoszytko B; Department of Dermatology, Allergology and Venereology, Medical University of Gdansk, 80-211 Gdansk, Poland.
Arock M; Department of Hematology, APHP, Hôpital Pitié-Salpêtrière and Sorbonne University, 75013 Paris, France.; Centre de Recherche des Cordeliers, INSERM, Sorbonne Université, Université de Paris, Cell Death and Drug Resistance in Hematological Disorders Team, 75006 Paris, France.
Lyons JJ; Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-188, USA.
Bachelot G; Department of Hematology, APHP, Hôpital Pitié-Salpêtrière and Sorbonne University, 75013 Paris, France.
Schwartz LB; Department of Internal Medicine, Division of Rheumatology, Allergy & Immunology, Virginia Commonwealth University, Richmond, VA 23298, USA.
Reiter A; University Hospital Mannheim, Heidelberg University, 68167 Mannheim, Germany.
Jawhar M; University Hospital Mannheim, Heidelberg University, 68167 Mannheim, Germany.
Schwaab J; University Hospital Mannheim, Heidelberg University, 68167 Mannheim, Germany.
Lange M; Department of Dermatology, Allergology and Venereology, Medical University of Gdansk, 80-211 Gdansk, Poland.
Greiner G; Department of Laboratory Medicine, Medical University of Vienna, 1090 Vienna, Austria.; Ludwig Boltzmann Institute for Hematology and Oncology, Medical University of Vienna, 1090 Vienna, Austria.; Ihr Labor, Medical Diagnostic Laboratories, 1220 Vienna, Austria.
Hoermann G; Ludwig Boltzmann Institute for Hematology and Oncology, Medical University of Vienna, 1090 Vienna, Austria.; MLL Munich Leukemia Laboratory, 81377 Munich, Germany.
Niedoszytko M; Department of Allergology, Medical University of Gdansk, 80-211 Gdansk, Poland.
Metcalfe DD; Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-188, USA.
Valent P; Ludwig Boltzmann Institute for Hematology and Oncology, Medical University of Vienna, 1090 Vienna, Austria.; Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, 1090 Vienna, Austria.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jan 02; Vol. 22 (1). Date of Electronic Publication: 2021 Jan 02.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Polymorphism, Genetic*
Cytokines/*genetics
Mastocytosis, Systemic/*genetics
Proto-Oncogene Proteins c-kit/*genetics
Toll-Like Receptor 2/*genetics
Humans ; Interleukin-13/genetics ; Interleukin-6/genetics ; Interleukins/genetics ; Mast Cells/pathology ; Mastocytosis, Systemic/diagnosis ; Mastocytosis, Systemic/metabolism ; Mastocytosis, Systemic/physiopathology ; Nerve Tissue Proteins/genetics ; Phospholipase C gamma/genetics ; Proto-Oncogene Proteins c-kit/metabolism ; Receptors, G-Protein-Coupled/genetics ; Receptors, Neuropeptide/genetics ; Toll-Like Receptor 2/metabolism
Czasopismo naukowe
Tytuł :
Antigen Expression Varies Significantly between Molecular Subgroups of Acute Myeloid Leukemia Patients: Clinical Applicability Is Hampered by Establishment of Relevant Cutoffs.
Autorzy :
Herborg LL; Department of Hematology, Aarhus University Hospital, Aarhus N, Denmark.
Nederby L; Department of Biochemistry and Immunology, Lillebaelt Hospital, University Hospital of Southern Denmark, Vejle, Denmark.
Brøndum RF; Department of Hematology, Clinical Cancer Research Center, Aalborg University Hospital, Aalborg, Denmark.
Hansen M; Department of Clinical Genetics, University Hospital of Copenhagen, Copenhagen, Denmark.
Hokland P; Department of Hematology, Aarhus University Hospital, Aarhus N, Denmark.
Roug AS; Department of Hematology, Clinical Cancer Research Center, Aalborg University Hospital, Aalborg, Denmark, .; Department of Clinical Medicine, Aalborg University, Aalborg, Denmark, .
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Źródło :
Acta haematologica [Acta Haematol] 2021; Vol. 144 (3), pp. 275-284. Date of Electronic Publication: 2020 Dec 03.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antigens, CD34/*metabolism
Interleukin-3 Receptor alpha Subunit/*metabolism
Lectins, C-Type/*metabolism
Leukemia, Myeloid, Acute/*diagnosis
Proto-Oncogene Proteins c-kit/*metabolism
Receptors, Mitogen/*metabolism
Adult ; Aged ; Aged, 80 and over ; Antigens, CD34/genetics ; Area Under Curve ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Immunophenotyping ; Interleukin-3 Receptor alpha Subunit/genetics ; Kaplan-Meier Estimate ; Lectins, C-Type/genetics ; Leukemia, Myeloid, Acute/metabolism ; Leukemia, Myeloid, Acute/mortality ; Male ; Middle Aged ; Mutation ; Proto-Oncogene Proteins c-kit/genetics ; ROC Curve ; Receptors, Mitogen/genetics ; Retrospective Studies ; Young Adult
Czasopismo naukowe
Tytuł :
Molecular Modeling Study of c-KIT/PDGFRα Dual Inhibitors for the Treatment of Gastrointestinal Stromal Tumors.
Autorzy :
Keretsu S; Department of Biomedical Sciences, College of Medicine, Chosun University, Gwangju 501-759, Korea.
Ghosh S; Department of Biomedical Sciences, College of Medicine, Chosun University, Gwangju 501-759, Korea.
Cho SJ; Department of Biomedical Sciences, College of Medicine, Chosun University, Gwangju 501-759, Korea.; Department of Cellular Molecular Medicine, College of Medicine, Chosun University, Gwangju 501-759, Korea.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Nov 03; Vol. 21 (21). Date of Electronic Publication: 2020 Nov 03.
Typ publikacji :
Journal Article
MeSH Terms :
Models, Molecular*
Gastrointestinal Neoplasms/*drug therapy
Gastrointestinal Stromal Tumors/*drug therapy
Protein Kinase Inhibitors/*isolation & purification
Proto-Oncogene Proteins c-kit/*antagonists & inhibitors
Receptor, Platelet-Derived Growth Factor alpha/*antagonists & inhibitors
Amino Acid Substitution ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/isolation & purification ; Antineoplastic Agents/pharmacokinetics ; Antineoplastic Agents/therapeutic use ; Binding Sites ; Drug Screening Assays, Antitumor/methods ; Humans ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Mutant Proteins/chemistry ; Mutant Proteins/genetics ; Mutant Proteins/metabolism ; Protein Kinase Inhibitors/chemistry ; Protein Kinase Inhibitors/pharmacokinetics ; Protein Kinase Inhibitors/therapeutic use ; Proto-Oncogene Proteins c-kit/chemistry ; Proto-Oncogene Proteins c-kit/genetics ; Proto-Oncogene Proteins c-kit/metabolism ; Pyrazoles/chemistry ; Pyridines/chemistry ; Quantitative Structure-Activity Relationship ; Receptor, Platelet-Derived Growth Factor alpha/chemistry ; Receptor, Platelet-Derived Growth Factor alpha/genetics ; Receptor, Platelet-Derived Growth Factor alpha/metabolism
Czasopismo naukowe
Tytuł :
A shift of dynamic equilibrium between the KIT active and inactive states causes drug resistance.
Autorzy :
Srikakulam SK; Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI), Saarbrücken, Germany.; Graduate School of Computer Science, Saarland University, Saarbrücken, Germany.; Interdisciplinary Graduate School of Natural Product Research, Saarland University, Saarbrücken, Germany.
Bastys T; Graduate School of Computer Science, Saarland University, Saarbrücken, Germany.; Max Planck Institute for Informatics, Saarbrücken, Germany.
Kalinina OV; Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI), Saarbrücken, Germany.; Medical Faculty, Saarland University, Homburg, Germany.
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Źródło :
Proteins [Proteins] 2020 Nov; Vol. 88 (11), pp. 1434-1446. Date of Electronic Publication: 2020 Jun 25.
Typ publikacji :
Journal Article
MeSH Terms :
Protein Processing, Post-Translational*
Antineoplastic Agents/*chemistry
Aspartic Acid/*chemistry
Protein Kinase Inhibitors/*chemistry
Proto-Oncogene Proteins c-kit/*chemistry
Tyrosine/*chemistry
Antineoplastic Agents/metabolism ; Aspartic Acid/metabolism ; Binding Sites ; Databases, Protein ; Drug Resistance, Neoplasm/genetics ; Humans ; Hydrogen Bonding ; Ligands ; Molecular Dynamics Simulation ; Mutation ; Phosphorylation ; Protein Binding ; Protein Conformation, alpha-Helical ; Protein Conformation, beta-Strand ; Protein Interaction Domains and Motifs ; Protein Kinase Inhibitors/metabolism ; Protein Stability ; Proto-Oncogene Proteins c-kit/antagonists & inhibitors ; Proto-Oncogene Proteins c-kit/genetics ; Proto-Oncogene Proteins c-kit/metabolism ; Substrate Specificity ; Thermodynamics ; Tyrosine/metabolism
Czasopismo naukowe
Tytuł :
Anti-human CD117 CAR T-cells efficiently eliminate healthy and malignant CD117-expressing hematopoietic cells.
Autorzy :
Myburgh R; Department of Medical Oncology and Hematology, University Hospital Zurich and University of Zurich, Comprehensive Cancer Center Zurich (CCCZ), Zurich, Switzerland.
Kiefer JD; Department of Medical Oncology and Hematology, University Hospital Zurich and University of Zurich, Comprehensive Cancer Center Zurich (CCCZ), Zurich, Switzerland.; Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, ETH Zurich, Comprehensive Cancer Center Zurich (CCCZ), Zurich, Switzerland.
Russkamp NF; Department of Medical Oncology and Hematology, University Hospital Zurich and University of Zurich, Comprehensive Cancer Center Zurich (CCCZ), Zurich, Switzerland.
Magnani CF; Department of Medical Oncology and Hematology, University Hospital Zurich and University of Zurich, Comprehensive Cancer Center Zurich (CCCZ), Zurich, Switzerland.
Nuñez N; Institute of Experimental Immunology, University of Zurich, Comprehensive Cancer Center Zurich (CCCZ), Zurich, Switzerland.
Simonis A; Department of Medical Oncology and Hematology, University Hospital Zurich and University of Zurich, Comprehensive Cancer Center Zurich (CCCZ), Zurich, Switzerland.
Pfister S; Department of Medical Oncology and Hematology, University Hospital Zurich and University of Zurich, Comprehensive Cancer Center Zurich (CCCZ), Zurich, Switzerland.
Wilk CM; Department of Medical Oncology and Hematology, University Hospital Zurich and University of Zurich, Comprehensive Cancer Center Zurich (CCCZ), Zurich, Switzerland.
McHugh D; Institute of Experimental Immunology, University of Zurich, Comprehensive Cancer Center Zurich (CCCZ), Zurich, Switzerland.
Friemel J; Institute of Pathology and Molecular Pathology, University and University Hospital Zurich, Comprehensive Cancer Center Zurich (CCCZ), Zurich, Switzerland.
Müller AM; Department of Medical Oncology and Hematology, University Hospital Zurich and University of Zurich, Comprehensive Cancer Center Zurich (CCCZ), Zurich, Switzerland.
Becher B; Institute of Experimental Immunology, University of Zurich, Comprehensive Cancer Center Zurich (CCCZ), Zurich, Switzerland.
Münz C; Institute of Experimental Immunology, University of Zurich, Comprehensive Cancer Center Zurich (CCCZ), Zurich, Switzerland.
van den Broek M; Institute of Experimental Immunology, University of Zurich, Comprehensive Cancer Center Zurich (CCCZ), Zurich, Switzerland.
Neri D; Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, ETH Zurich, Comprehensive Cancer Center Zurich (CCCZ), Zurich, Switzerland.
Manz MG; Department of Medical Oncology and Hematology, University Hospital Zurich and University of Zurich, Comprehensive Cancer Center Zurich (CCCZ), Zurich, Switzerland. .
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Źródło :
Leukemia [Leukemia] 2020 Oct; Vol. 34 (10), pp. 2688-2703. Date of Electronic Publication: 2020 May 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Immunotherapy, Adoptive*
Proto-Oncogene Proteins c-kit/*antagonists & inhibitors
Receptors, Antigen, T-Cell/*immunology
Receptors, Chimeric Antigen/*immunology
T-Lymphocytes/*immunology
T-Lymphocytes/*metabolism
Animals ; Biomarkers ; Biopsy ; Bone Marrow/metabolism ; Bone Marrow/pathology ; Cell Line, Tumor ; Disease Models, Animal ; Gene Expression ; Hematologic Neoplasms/diagnosis ; Hematologic Neoplasms/immunology ; Hematologic Neoplasms/metabolism ; Hematologic Neoplasms/therapy ; Hematopoietic Stem Cells/immunology ; Hematopoietic Stem Cells/metabolism ; Humans ; Immunophenotyping ; Leukemia, Myeloid, Acute/genetics ; Leukemia, Myeloid, Acute/immunology ; Leukemia, Myeloid, Acute/pathology ; Leukemia, Myeloid, Acute/therapy ; Lymphocyte Depletion ; Mice ; Proto-Oncogene Proteins c-kit/genetics ; Proto-Oncogene Proteins c-kit/metabolism ; Receptors, Antigen, T-Cell/genetics ; Receptors, Chimeric Antigen/genetics ; Treatment Outcome ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Switch Control Inhibition of KIT and PDGFRA in Patients With Advanced Gastrointestinal Stromal Tumor: A Phase I Study of Ripretinib.
Autorzy :
Janku F; Department of Investigational Cancer Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX.
Abdul Razak AR; Toronto Sarcoma Program, Princess Margaret Cancer Centre, Toronto, Ontario, Canada.
Chi P; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY and Department of Medicine, Weill Cornell Medicine, New York, NY.
Heinrich MC; Department of Medicine, Portland VA Health Care System and OHSU Knight Cancer Institute, Oregon Health & Science University, Portland, OR.
von Mehren M; Department of Hematology and Medical Oncology, Fox Chase Cancer Center, Philadelphia, PA.
Jones RL; Sarcoma Unit, The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, London, United Kingdom.
Ganjoo K; Department of Oncology, Stanford University Medical Center, Palo Alto, CA.
Trent J; Department of Medicine, Sylvester Comprehensive Cancer Center, University of Miami Health System, Miami, FL.
Gelderblom H; Department of Medical Oncology, Leiden University Medical Center, Leiden, the Netherlands.
Somaiah N; Department of Sarcoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX.
Hu S; Deciphera Pharmaceuticals, LLC, Waltham, MA.
Rosen O; Deciphera Pharmaceuticals, LLC, Waltham, MA.
Su Y; Deciphera Pharmaceuticals, LLC, Waltham, MA.
Ruiz-Soto R; Deciphera Pharmaceuticals, LLC, Waltham, MA.
Gordon M; HonorHealth Research Institute, Scottsdale, AZ.
George S; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA.
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Źródło :
Journal of clinical oncology : official journal of the American Society of Clinical Oncology [J Clin Oncol] 2020 Oct 01; Vol. 38 (28), pp. 3294-3303. Date of Electronic Publication: 2020 Aug 17.
Typ publikacji :
Clinical Trial, Phase I; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Gastrointestinal Neoplasms/*drug therapy
Gastrointestinal Stromal Tumors/*drug therapy
Naphthyridines/*administration & dosage
Proto-Oncogene Proteins c-kit/*antagonists & inhibitors
Receptor, Platelet-Derived Growth Factor alpha/*antagonists & inhibitors
Urea/*analogs & derivatives
Adolescent ; Adult ; Aged ; Dose-Response Relationship, Drug ; Female ; Gastrointestinal Neoplasms/genetics ; Gastrointestinal Neoplasms/metabolism ; Gastrointestinal Stromal Tumors/genetics ; Gastrointestinal Stromal Tumors/metabolism ; Humans ; Male ; Middle Aged ; Naphthyridines/adverse effects ; Naphthyridines/pharmacokinetics ; Progression-Free Survival ; Proto-Oncogene Proteins c-kit/genetics ; Proto-Oncogene Proteins c-kit/metabolism ; Receptor, Platelet-Derived Growth Factor alpha/genetics ; Receptor, Platelet-Derived Growth Factor alpha/metabolism ; Urea/administration & dosage ; Urea/adverse effects ; Urea/pharmacokinetics ; Young Adult
Czasopismo naukowe
Tytuł :
RUNX1/ETO and mutant KIT both contribute to programming the transcriptional and chromatin landscape in t(8;21) acute myeloid leukemia.
Autorzy :
Chin PS; Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.
Assi SA; Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.
Ptasinska A; Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.
Imperato MR; Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.
Cockerill PN; Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.
Bonifer C; Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK. Electronic address: c..
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Źródło :
Experimental hematology [Exp Hematol] 2020 Dec; Vol. 92, pp. 62-74. Date of Electronic Publication: 2020 Nov 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Chromosomes, Human, Pair 21*/genetics
Chromosomes, Human, Pair 21*/metabolism
Chromosomes, Human, Pair 8*/genetics
Chromosomes, Human, Pair 8*/metabolism
Leukemia, Myeloid, Acute*/genetics
Leukemia, Myeloid, Acute*/metabolism
Leukemia, Myeloid, Acute*/pathology
Mutation, Missense*
Transcription, Genetic*
Translocation, Genetic*
Chromatin/*metabolism
Core Binding Factor Alpha 2 Subunit/*metabolism
Proto-Oncogene Proteins c-kit/*metabolism
RUNX1 Translocation Partner 1 Protein/*metabolism
Amino Acid Substitution ; Chromatin/pathology ; Core Binding Factor Alpha 2 Subunit/genetics ; Female ; Gene Expression Regulation, Leukemic ; HEK293 Cells ; Humans ; Male ; Proto-Oncogene Proteins c-kit/genetics ; RUNX1 Translocation Partner 1 Protein/genetics
Czasopismo naukowe
Tytuł :
The V654A second-site KIT mutation increases tumor oncogenesis and STAT activation in a mouse model of gastrointestinal stromal tumor.
Autorzy :
Zhang JQ; Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Bosbach B; Developmental Biology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Loo JK; Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Vitiello GA; Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Zeng S; Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Seifert AM; Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Medina BD; Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Param NJ; Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Maltbaek JH; Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Rossi F; Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.
Antonescu CR; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Besmer P; Developmental Biology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
DeMatteo RP; Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA. .; Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA, USA. .
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Źródło :
Oncogene [Oncogene] 2020 Dec; Vol. 39 (49), pp. 7153-7165. Date of Electronic Publication: 2020 Oct 06.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Mutation*
Carcinogenesis/*genetics
Gastrointestinal Neoplasms/*genetics
Gastrointestinal Stromal Tumors/*genetics
Proto-Oncogene Proteins c-kit/*genetics
STAT Transcription Factors/*metabolism
Animals ; Disease Models, Animal ; Gastrointestinal Neoplasms/pathology ; Gastrointestinal Stromal Tumors/pathology ; Humans ; Mice ; Proto-Oncogene Proteins c-kit/metabolism ; Signal Transduction/genetics ; Tumor Microenvironment/genetics
Czasopismo naukowe
Tytuł :
Tissue Inhibitor of Matrix Metalloproteinase 2-Loaded Polylactic Acid-Polyethylene Glycol Nanoparticles Directly Regulates Renal Tubular Epithelial Cell Proliferation via Protein Tyrosine Kinase KIT.
Autorzy :
Ke X; Department of Nephrology, The Third Affiliated Hospital, Southern Medical University, Guangzhou 510000, Guangdong, PR China.
Zhou Q; Department of Nephrology, The Third Affiliated Hospital, Southern Medical University, Guangzhou 510000, Guangdong, PR China.
Li B; Department of Nephrology, The Third Affiliated Hospital, Southern Medical University, Guangzhou 510000, Guangdong, PR China.
Shao X; Department of Nephrology, The Third Affiliated Hospital, Southern Medical University, Guangzhou 510000, Guangdong, PR China.
Hong G; Department of Nephrology, Affiliated Nanhai Hospital, South Medical University, Foshan 528200, Guangdong, PR China.
Zou H; Department of Nephrology, The Third Affiliated Hospital, Southern Medical University, Guangzhou 510000, Guangdong, PR China.
Ling Y; School of Pharmaceutical Sciences (Shenzhen), Sun Yat-Sen University, Guangzhou 510006, Guangdong, PR China.
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Źródło :
Journal of nanoscience and nanotechnology [J Nanosci Nanotechnol] 2020 Dec 01; Vol. 20 (12), pp. 7425-7432.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Proliferation*
Nanoparticles*
Proto-Oncogene Proteins c-kit*
Tissue Inhibitor of Metalloproteinase-2*
Epithelial Cells/*drug effects
Epithelial Cells/cytology ; Humans ; Kidney Tubules/cytology ; Polyesters ; Polyethylene Glycols/pharmacology ; Protein-Tyrosine Kinases
Czasopismo naukowe
Tytuł :
Engineering Stem Cell Factor Ligands with Different c-Kit Agonistic Potencies.
Autorzy :
Tilayov T; Avram and Stella Goldstein-Goren Department of Biotechnology Engineering and the National Institute of Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel.
Hingaly T; Avram and Stella Goldstein-Goren Department of Biotechnology Engineering and the National Institute of Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel.
Greenshpan Y; Shraga Segal Department of Microbiology, Immunology and Genetics and the National Institute of Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel.
Cohen S; Department of Chemistry and the National Institute for Biotechnology in the Negev (NIBN), Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel.
Akabayov B; Department of Chemistry and the National Institute for Biotechnology in the Negev (NIBN), Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel.
Gazit R; Shraga Segal Department of Microbiology, Immunology and Genetics and the National Institute of Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel.
Papo N; Avram and Stella Goldstein-Goren Department of Biotechnology Engineering and the National Institute of Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2020 Oct 21; Vol. 25 (20). Date of Electronic Publication: 2020 Oct 21.
Typ publikacji :
Journal Article
MeSH Terms :
Proto-Oncogene Proteins c-kit/*agonists
Stem Cell Factor/*pharmacology
Cell Line, Tumor ; Humans ; Phosphorylation ; Proto-Oncogene Proteins c-kit/metabolism ; Stem Cell Factor/genetics
Czasopismo naukowe
Tytuł :
Evidence supports white spotting in donkeys as a homozygous lethal condition.
Autorzy :
Tanaka J; Veterinary Genetics Laboratory, School of Veterinary Medicine, University of California, Davis, CA, 95616, USA.
Grahn R; Veterinary Genetics Laboratory, School of Veterinary Medicine, University of California, Davis, CA, 95616, USA.
Bellone RR; Veterinary Genetics Laboratory, School of Veterinary Medicine, University of California, Davis, CA, 95616, USA.; Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, CA, 95616, USA.
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Źródło :
Animal genetics [Anim Genet] 2020 Oct; Vol. 51 (5), pp. 840-842. Date of Electronic Publication: 2020 Jul 13.
Typ publikacji :
Journal Article
MeSH Terms :
Equidae/*physiology
Genes, Lethal/*genetics
Hair Color/*genetics
Proto-Oncogene Proteins c-kit/*genetics
Animals ; Equidae/genetics ; Genes, Recessive/genetics ; Homozygote ; Mutation ; Proto-Oncogene Proteins c-kit/metabolism
Czasopismo naukowe
Tytuł :
KIT and Melanoma: Biological Insights and Clinical Implications.
Autorzy :
Pham DDM; Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, Korea.
Guhan S; Harvard Medical School, Boston, MA, USA.
Tsao H; Harvard Medical School, Boston, MA, USA.; Department of Dermatology, Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. .
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Źródło :
Yonsei medical journal [Yonsei Med J] 2020 Jul; Vol. 61 (7), pp. 562-571.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Antineoplastic Agents/*therapeutic use
Biomarkers, Tumor/*metabolism
Drug Resistance, Neoplasm/*genetics
Melanoma/*drug therapy
Melanoma/*metabolism
Proto-Oncogene Proteins c-kit/*therapeutic use
Signal Transduction/*drug effects
Skin Neoplasms/*drug therapy
Skin Neoplasms/*metabolism
Female ; Humans ; Male ; Melanoma/genetics ; Mucous Membrane/metabolism ; Mutation ; Proto-Oncogene Proteins c-kit/genetics ; Proto-Oncogene Proteins c-kit/metabolism ; Receptor Protein-Tyrosine Kinases/genetics ; Skin Neoplasms/genetics
Czasopismo naukowe
Tytuł :
Development and characterization of a fully human antibody targeting SCF/c-kit signaling.
Autorzy :
Kim JO; College of Pharmacy and Research Institute of Pharmaceutical Science and Technology (RIPST), Ajou University, 206 World Cup-ro, Yeongtong-gu, Suwon-si, Gyeonggi-do 16499, Republic of Korea.
Kim HN; College of Pharmacy and Research Institute of Pharmaceutical Science and Technology (RIPST), Ajou University, 206 World Cup-ro, Yeongtong-gu, Suwon-si, Gyeonggi-do 16499, Republic of Korea; Department of Molecular Science and Technology, Ajou University, 206 World Cup-ro, Yeongtong-gu, Suwon-si, Gyeonggi-do 16499, Republic of Korea.
Kim KH; College of Pharmacy and Research Institute of Pharmaceutical Science and Technology (RIPST), Ajou University, 206 World Cup-ro, Yeongtong-gu, Suwon-si, Gyeonggi-do 16499, Republic of Korea.
Baek EJ; College of Pharmacy and Research Institute of Pharmaceutical Science and Technology (RIPST), Ajou University, 206 World Cup-ro, Yeongtong-gu, Suwon-si, Gyeonggi-do 16499, Republic of Korea.
Park JY; College of Pharmacy and Research Institute of Pharmaceutical Science and Technology (RIPST), Ajou University, 206 World Cup-ro, Yeongtong-gu, Suwon-si, Gyeonggi-do 16499, Republic of Korea; Department of Molecular Science and Technology, Ajou University, 206 World Cup-ro, Yeongtong-gu, Suwon-si, Gyeonggi-do 16499, Republic of Korea.
Ha K; New Drug Development Center, Osong Medical Innovation Foundation, Osong 28160, Republic of Korea.
Heo DR; New Drug Development Center, Osong Medical Innovation Foundation, Osong 28160, Republic of Korea; College of Pharmacy and Medical Research Center, Chungbuk National University, Osongsaengmyeong 1-ro, Osong 28160, Republic of Korea.
Seo MD; College of Pharmacy and Research Institute of Pharmaceutical Science and Technology (RIPST), Ajou University, 206 World Cup-ro, Yeongtong-gu, Suwon-si, Gyeonggi-do 16499, Republic of Korea; Department of Molecular Science and Technology, Ajou University, 206 World Cup-ro, Yeongtong-gu, Suwon-si, Gyeonggi-do 16499, Republic of Korea; Novelty Nobility, 227 Unjung-ro, Seongnam-si, Gyeonggi-do 13477, Republic of Korea. Electronic address: .
Park SG; College of Pharmacy and Research Institute of Pharmaceutical Science and Technology (RIPST), Ajou University, 206 World Cup-ro, Yeongtong-gu, Suwon-si, Gyeonggi-do 16499, Republic of Korea; Novelty Nobility, 227 Unjung-ro, Seongnam-si, Gyeonggi-do 13477, Republic of Korea. Electronic address: .
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Źródło :
International journal of biological macromolecules [Int J Biol Macromol] 2020 Sep 15; Vol. 159, pp. 66-78. Date of Electronic Publication: 2020 May 11.
Typ publikacji :
Journal Article
MeSH Terms :
Antibodies, Neutralizing/*immunology
Antineoplastic Agents, Immunological/*immunology
Proto-Oncogene Proteins c-kit/*immunology
Animals ; Antibodies, Neutralizing/chemistry ; Antibodies, Neutralizing/pharmacology ; Antineoplastic Agents, Immunological/chemistry ; Antineoplastic Agents, Immunological/pharmacology ; Binding Sites, Antibody ; Cell Proliferation/drug effects ; Cells, Cultured ; Epitopes/chemistry ; Epitopes/immunology ; HEK293 Cells ; Haplorhini ; Humans ; Mice ; Proto-Oncogene Proteins c-kit/antagonists & inhibitors ; Rats
Czasopismo naukowe
Tytuł :
Blastic transformation of BCR-ABL1 positive chronic myeloid leukaemia through acquisition of CBFB-MYH11 and mutant KIT.
Autorzy :
Shoumariyeh K; Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; German Cancer Consortium (DKTK), Freiburg, Germany.
Hussung S; Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Niemöller C; Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Bleul S; Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Veratti P; Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Follo M; Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Riba J; Department of Microsystems Engineering - IMTEK, University of Freiburg, Freiburg, Germany.
Philipp U; Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Palmer JM; Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Pfeifer D; Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Pantic M; Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Meggendorfer M; MLL Munich Leukemia Laboratory, Munich, Germany.
Hackanson B; Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; Department of Hematology/Oncology, University Medical Center Augsburg, Augsburg, Germany.
Finke J; Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Haferlach T; MLL Munich Leukemia Laboratory, Munich, Germany.
Duyster J; Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; German Cancer Consortium (DKTK), Freiburg, Germany.; German Cancer Research Center (DKFZ), Heidelberg, Germany.
Miething C; Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; German Cancer Consortium (DKTK), Freiburg, Germany.; German Cancer Research Center (DKFZ), Heidelberg, Germany.
Becker H; Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
von Bubnoff N; Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; Department of Hematology and Oncology, Medical Center, University of Schleswig-Holstein, Lubeck, Germany.
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Źródło :
British journal of haematology [Br J Haematol] 2020 Sep; Vol. 190 (6), pp. e339-e343. Date of Electronic Publication: 2020 Jun 24.
Typ publikacji :
Case Reports; Letter; Research Support, Non-U.S. Gov't
MeSH Terms :
Blast Crisis*/drug therapy
Blast Crisis*/genetics
Blast Crisis*/metabolism
Blast Crisis*/pathology
Fusion Proteins, bcr-abl*/genetics
Fusion Proteins, bcr-abl*/metabolism
Leukemia, Myelogenous, Chronic, BCR-ABL Positive*/drug therapy
Leukemia, Myelogenous, Chronic, BCR-ABL Positive*/genetics
Leukemia, Myelogenous, Chronic, BCR-ABL Positive*/metabolism
Leukemia, Myelogenous, Chronic, BCR-ABL Positive*/pathology
Oncogene Proteins, Fusion*/genetics
Oncogene Proteins, Fusion*/metabolism
Proto-Oncogene Proteins c-kit*/genetics
Proto-Oncogene Proteins c-kit*/metabolism
Pyrimidines/*administration & dosage
Adult ; Humans ; Male
Raport
Tytuł :
c-KIT regulates stability of cancer stemness in CD44-positive colorectal cancer cells.
Autorzy :
Tomizawa F; Division of Molecular Biotherapy, Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Tokyo, Japan; Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan.
Jang MK; Division of Molecular Biotherapy, Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Tokyo, Japan; Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan.
Mashima T; Division of Molecular Biotherapy, Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Tokyo, Japan.
Seimiya H; Division of Molecular Biotherapy, Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Tokyo, Japan; Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan. Electronic address: .
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2020 Jul 05; Vol. 527 (4), pp. 1014-1020. Date of Electronic Publication: 2020 May 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Colorectal Neoplasms/*pathology
Hyaluronan Receptors/*analysis
Neoplastic Stem Cells/*pathology
Proto-Oncogene Proteins c-kit/*analysis
Animals ; Biomarkers, Tumor/analysis ; Biomarkers, Tumor/genetics ; Cell Line, Tumor ; Colorectal Neoplasms/genetics ; Gene Expression Regulation, Neoplastic ; Humans ; Hyaluronan Receptors/genetics ; Mice ; Neoplastic Stem Cells/metabolism ; Proto-Oncogene Proteins c-kit/genetics
Czasopismo naukowe
Tytuł :
Pressure overload by suprarenal aortic constriction in mice leads to left ventricular hypertrophy without c-Kit expression in cardiomyocytes.
Autorzy :
Nicks AM; Division of Molecular Cardiology and Biophysics, Victor Chang Cardiac Research Institute, 405 Liverpool Street, Darlinghurst, Sydney, NSW, 2010, Australia.; St Vincent's Clinical School, University of New South Wales, Sydney, NSW, 2052, Australia.
Kesteven SH; Division of Molecular Cardiology and Biophysics, Victor Chang Cardiac Research Institute, 405 Liverpool Street, Darlinghurst, Sydney, NSW, 2010, Australia.; St Vincent's Clinical School, University of New South Wales, Sydney, NSW, 2052, Australia.
Li M; Division of Molecular Cardiology and Biophysics, Victor Chang Cardiac Research Institute, 405 Liverpool Street, Darlinghurst, Sydney, NSW, 2010, Australia.; Cardiac Regeneration Research Institute, Wenzhou Medical University, Wenzhou, 325035, China.
Wu J; Division of Molecular Cardiology and Biophysics, Victor Chang Cardiac Research Institute, 405 Liverpool Street, Darlinghurst, Sydney, NSW, 2010, Australia.
Chan AY; Division of Molecular Cardiology and Biophysics, Victor Chang Cardiac Research Institute, 405 Liverpool Street, Darlinghurst, Sydney, NSW, 2010, Australia.
Naqvi N; Department of Medicine, Emory University, Atlanta, GA, 30322, USA.
Husain A; Department of Medicine, Emory University, Atlanta, GA, 30322, USA.
Feneley MP; Division of Molecular Cardiology and Biophysics, Victor Chang Cardiac Research Institute, 405 Liverpool Street, Darlinghurst, Sydney, NSW, 2010, Australia.; St Vincent's Clinical School, University of New South Wales, Sydney, NSW, 2052, Australia.
Smith NJ; Division of Molecular Cardiology and Biophysics, Victor Chang Cardiac Research Institute, 405 Liverpool Street, Darlinghurst, Sydney, NSW, 2010, Australia.; St Vincent's Clinical School, University of New South Wales, Sydney, NSW, 2052, Australia.
Iismaa SE; Division of Molecular Cardiology and Biophysics, Victor Chang Cardiac Research Institute, 405 Liverpool Street, Darlinghurst, Sydney, NSW, 2010, Australia.; St Vincent's Clinical School, University of New South Wales, Sydney, NSW, 2052, Australia.
Graham RM; Division of Molecular Cardiology and Biophysics, Victor Chang Cardiac Research Institute, 405 Liverpool Street, Darlinghurst, Sydney, NSW, 2010, Australia. .; St Vincent's Clinical School, University of New South Wales, Sydney, NSW, 2052, Australia. .
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Źródło :
Scientific reports [Sci Rep] 2020 Sep 18; Vol. 10 (1), pp. 15318. Date of Electronic Publication: 2020 Sep 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Hypertrophy, Left Ventricular/*pathology
Myocytes, Cardiac/*pathology
Proto-Oncogene Proteins c-kit/*metabolism
Animals ; Aorta/physiopathology ; Constriction, Pathologic ; Gene Expression Regulation ; Hypertension/etiology ; Hypertension/physiopathology ; Hypertrophy, Left Ventricular/genetics ; Male ; Mice, Inbred C57BL ; Mice, Transgenic ; Pressure ; Proto-Oncogene Proteins c-kit/genetics ; Renal Circulation ; Renin/genetics ; Ventricular Dysfunction, Left/genetics ; Ventricular Dysfunction, Left/physiopathology ; Ventricular Remodeling/genetics ; Ventricular Remodeling/physiology
Czasopismo naukowe

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