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Wyszukujesz frazę ""carcinogenesis"" wg kryterium: Temat


Tytuł :
Cellular Nrf2 Levels Determine Cell Fate during Chemical Carcinogenesis in Esophageal Epithelium.
Autorzy :
Horiuchi M; Department of Medical Biochemistry, Tohoku University, Sendai, Japan.; Department of Surgery, Graduate School of Medicine, Tohoku University, Sendai, Japan.
Taguchi K; Department of Medical Biochemistry, Tohoku University, Sendai, Japan.; Department of Medical Biochemistry, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.; Advanced Research Center for Innovations in Next-Generation Medicine (INGEM), Tohoku University, Sendai, Japan.
Hirose W; Department of Medical Biochemistry, Tohoku University, Sendai, Japan.; Department of Surgery, Graduate School of Medicine, Tohoku University, Sendai, Japan.
Tsuchida K; Department of Medical Biochemistry, Tohoku University, Sendai, Japan.
Suzuki M; Center for Radioisotope Sciences, Tohoku University, Sendai, Japan.
Taniyama Y; Department of Surgery, Graduate School of Medicine, Tohoku University, Sendai, Japan.
Kamei T; Department of Surgery, Graduate School of Medicine, Tohoku University, Sendai, Japan.
Yamamoto M; Department of Medical Biochemistry, Tohoku University, Sendai, Japan .; Department of Medical Biochemistry, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.; Advanced Research Center for Innovations in Next-Generation Medicine (INGEM), Tohoku University, Sendai, Japan.
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Źródło :
Molecular and cellular biology [Mol Cell Biol] 2021 Jan 25; Vol. 41 (2). Date of Electronic Publication: 2021 Jan 25 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation, Neoplastic*
4-Nitroquinoline-1-oxide/*pharmacology
Carcinogenesis/*genetics
Carcinogens/*pharmacology
Esophageal Neoplasms/*genetics
NF-E2-Related Factor 2/*genetics
Alleles ; Animals ; Carcinogenesis/chemically induced ; Carcinogenesis/metabolism ; Carcinogenesis/pathology ; DNA Damage ; Epithelium/drug effects ; Epithelium/metabolism ; Epithelium/pathology ; Esophageal Neoplasms/chemically induced ; Esophageal Neoplasms/metabolism ; Esophageal Neoplasms/pathology ; Esophagus/drug effects ; Esophagus/metabolism ; Esophagus/pathology ; Genes, Reporter ; Integrases/genetics ; Integrases/metabolism ; Luminescent Proteins/genetics ; Luminescent Proteins/metabolism ; Male ; Mice ; Mice, Knockout ; NF-E2-Related Factor 2/deficiency ; Oxidative Stress ; Signal Transduction ; Tamoxifen/pharmacology
Czasopismo naukowe
Tytuł :
c-Src promotes the growth and tumorigenesis of hepatocellular carcinoma via the Hippo signaling pathway.
Autorzy :
Yang J; Department of Pharmacy, Fujian Medical University Union Hospital, Fuzhou 350001, Fujian, China.
Zhang X; Department of Ultrasound, Fujian Medical University Union Hospital, Fuzhou 350001, Fujian, China. Electronic address: .
Liu L; Department of Ultrasound, The Second People's Hospital of Fujian Province, Fuzhou 350001, Fujian, China.
Yang X; Department of Pharmacy, Fujian Medical University Union Hospital, Fuzhou 350001, Fujian, China.
Qian Q; Department of Ultrasound, Fujian Medical University Union Hospital, Fuzhou 350001, Fujian, China.
Du B; Department of Oncology, Fujian Medical University Union Hospital, Fuzhou 350001, Fujian, China.
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Źródło :
Life sciences [Life Sci] 2021 Jan 01; Vol. 264, pp. 118711. Date of Electronic Publication: 2020 Nov 10.
Typ publikacji :
Journal Article
MeSH Terms :
Signal Transduction*/drug effects
Carcinogenesis/*metabolism
Carcinogenesis/*pathology
Carcinoma, Hepatocellular/*enzymology
Carcinoma, Hepatocellular/*pathology
Liver Neoplasms/*enzymology
Liver Neoplasms/*pathology
Protein-Serine-Threonine Kinases/*metabolism
Proto-Oncogene Proteins pp60(c-src)/*metabolism
Adaptor Proteins, Signal Transducing/genetics ; Adaptor Proteins, Signal Transducing/metabolism ; Animals ; Apoptosis/drug effects ; Apoptosis/genetics ; Carcinogenesis/drug effects ; Carcinogenesis/genetics ; Carcinoma, Hepatocellular/genetics ; Cell Cycle Checkpoints/drug effects ; Cell Cycle Checkpoints/genetics ; Cell Line, Tumor ; Cell Movement/drug effects ; Cell Movement/genetics ; Cell Nucleus/drug effects ; Cell Nucleus/metabolism ; Cell Proliferation/drug effects ; Cell Proliferation/genetics ; Down-Regulation/drug effects ; Down-Regulation/genetics ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Liver Neoplasms/genetics ; Male ; Mice, Nude ; Neoplasm Invasiveness ; Prognosis ; Protein Kinase Inhibitors/pharmacology ; Proto-Oncogene Proteins pp60(c-src)/antagonists & inhibitors ; Proto-Oncogene Proteins pp60(c-src)/genetics ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Transcription, Genetic/drug effects ; Up-Regulation/drug effects
Czasopismo naukowe
Tytuł :
C8orf48 inhibits the tumorigenesis of colorectal cancer by regulating the MAPK signaling pathway.
Autorzy :
Lei L; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, School of Medicine, Northwest University, Xi'an 710069, China. Electronic address: .
An G; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, School of Medicine, Northwest University, Xi'an 710069, China.
Zhu Z; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, School of Medicine, Northwest University, Xi'an 710069, China.
Liu S; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, School of Medicine, Northwest University, Xi'an 710069, China.
Fu Y; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, School of Medicine, Northwest University, Xi'an 710069, China.
Zeng X; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, School of Medicine, Northwest University, Xi'an 710069, China.
Cao Q; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, School of Medicine, Northwest University, Xi'an 710069, China.
Yan B; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, School of Medicine, Northwest University, Xi'an 710069, China.
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Źródło :
Life sciences [Life Sci] 2021 Feb 01; Vol. 266, pp. 118872. Date of Electronic Publication: 2020 Dec 09.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Expression Regulation, Neoplastic*
MAP Kinase Signaling System*
Biomarkers, Tumor/*metabolism
Carcinogenesis/*pathology
Colorectal Neoplasms/*pathology
MicroRNAs/*genetics
Neoplasm Proteins/*metabolism
Apoptosis ; Biomarkers, Tumor/genetics ; Carcinogenesis/genetics ; Carcinogenesis/metabolism ; Cell Movement ; Cell Proliferation ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/metabolism ; Humans ; Neoplasm Invasiveness ; Neoplasm Proteins/genetics ; Prognosis ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
Lung cancer pathogenesis and poor response to therapy were dependent on driver oncogenic mutations.
Autorzy :
Sun X; Department of Thoracic Surgery, the Second Department of Thoracic Surgery, Department of Thoracic Surgery and Oncology, Cancer Center, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an City, Shaanxi Province 710061, China. Electronic address: .
Li K; Department of Thoracic Surgery, the Second Department of Thoracic Surgery, Department of Thoracic Surgery and Oncology, Cancer Center, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an City, Shaanxi Province 710061, China.
Zhao R; Department of Thoracic Surgery, the Second Department of Thoracic Surgery, Department of Thoracic Surgery and Oncology, Cancer Center, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an City, Shaanxi Province 710061, China.
Sun Y; Department of Anesthesiology and Operation, Operating Centre, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an City, Shaanxi Province 710061, China.
Xu J; Department of Thoracic Surgery, the Second Department of Thoracic Surgery, Department of Thoracic Surgery and Oncology, Cancer Center, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an City, Shaanxi Province 710061, China; Department of General Surgery, the People's Hospital of Shanyang County, Luonan City, Shaanxi Province 726411, China.
Peng ZY; Department of Thoracic Surgery, the Second Department of Thoracic Surgery, Department of Thoracic Surgery and Oncology, Cancer Center, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an City, Shaanxi Province 710061, China.
Song RD; Department of Thoracic Surgery, the Second Department of Thoracic Surgery, Department of Thoracic Surgery and Oncology, Cancer Center, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an City, Shaanxi Province 710061, China.
Ren H; Department of Thoracic Surgery, the Second Department of Thoracic Surgery, Department of Thoracic Surgery and Oncology, Cancer Center, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an City, Shaanxi Province 710061, China.
Tang SC; University of Mississippi Medical Center, Cancer Center and Research Institute, 2500 North State Street, Jackson, MS 39216, USA. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Jan 15; Vol. 265, pp. 118797. Date of Electronic Publication: 2020 Dec 04.
Typ publikacji :
Journal Article
MeSH Terms :
Adenocarcinoma of Lung/*genetics
Carcinogenesis/*genetics
Lung Neoplasms/*genetics
Mutation/*genetics
Oncogenes/*genetics
Smoking/*genetics
Adenocarcinoma of Lung/pathology ; Adenocarcinoma of Lung/therapy ; Aged ; Biomarkers, Tumor/genetics ; Carcinogenesis/drug effects ; Carcinogenesis/pathology ; Female ; Humans ; Lung Neoplasms/pathology ; Lung Neoplasms/therapy ; Male ; Middle Aged ; Mutation/drug effects ; Oncogenes/drug effects ; Smoking/pathology ; Smoking/therapy ; Survival Rate/trends ; Treatment Outcome
Czasopismo naukowe
Tytuł :
CNCDatabase: a database of non-coding cancer drivers.
Autorzy :
Liu EM; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10017, USA.; Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA.; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY 10065, USA.; Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY 10021, USA.
Martinez-Fundichely A; Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA.; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY 10065, USA.; Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY 10021, USA.
Bollapragada R; Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY 10021, USA.
Spiewack M; Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY 10021, USA.
Khurana E; Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA.; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY 10065, USA.; Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY 10021, USA.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2021 Jan 08; Vol. 49 (D1), pp. D1094-D1101.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Databases, Genetic*
Gene Expression Regulation, Neoplastic*
Genome, Human*
Carcinogenesis/*genetics
Neoplasms/*genetics
3' Untranslated Regions ; 5' Untranslated Regions ; Carcinogenesis/metabolism ; Carcinogenesis/pathology ; Clustered Regularly Interspaced Short Palindromic Repeats ; Enhancer Elements, Genetic ; Genes, Reporter ; Humans ; Insulator Elements ; Luciferases/genetics ; Luciferases/metabolism ; Mutation ; Neoplasms/metabolism ; Neoplasms/pathology ; Open Reading Frames ; Promoter Regions, Genetic ; RNA, Untranslated/classification ; RNA, Untranslated/genetics ; RNA, Untranslated/metabolism ; Untranslated Regions ; Whole Genome Sequencing
Czasopismo naukowe
Tytuł :
OncoVar: an integrated database and analysis platform for oncogenic driver variants in cancers.
Autorzy :
Wang T; Center for Medical Genetics & Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, Changsha, Hunan 410083, China.; Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing 100101, China.
Ruan S; Department of Clinical Oncology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430072, China.
Zhao X; Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, China.
Shi X; Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing 100101, China.
Teng H; Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing 100101, China.
Zhong J; Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases of Ministry of Education, Gannan Medical University, Ganzhou 341000, China.
You M; Baiyining Medicine, Beijing 102200, China.
Xia K; Center for Medical Genetics & Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, Changsha, Hunan 410083, China.; CAS Center for Excellence in Brain Science and Intelligences Technology (CEBSIT), Shanghai 200031, China.; School of Basic Medical Science, Central South University, Changsha, Hunan 410078, China.
Sun Z; Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing 100101, China.; CAS Center for Excellence in Biotic Interactions, University of Chinese Academy of Sciences, Beijing 100049, China.; State Key Laboratory of Integrated Management of Pest Insects and Rodents, Chinese Academy of Sciences, Beijing 100101, China.
Mao F; Center of Basic Medical Research, Institute of Medical Innovation and Research, Peking University Third Hospital, Beijing 100191, China.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2021 Jan 08; Vol. 49 (D1), pp. D1289-D1301.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Databases, Genetic*
Gene Expression Regulation, Neoplastic*
Mutation*
Software*
Carcinogenesis/*genetics
Neoplasm Proteins/*genetics
Neoplasms/*genetics
Algorithms ; Carcinogenesis/metabolism ; Carcinogenesis/pathology ; Computational Biology ; Exome ; Humans ; Internet ; Metabolic Networks and Pathways/genetics ; Molecular Sequence Annotation ; Neoplasm Proteins/metabolism ; Neoplasms/classification ; Neoplasms/metabolism ; Neoplasms/pathology ; Oncogenes
Czasopismo naukowe
Tytuł :
A RAC-GEF network critical for early intestinal tumourigenesis.
Autorzy :
Pickering KA; CRUK Beatson Institute, Garscube Estate, Switchback Road, Glasgow, G61 1BD, UK.
Gilroy K; CRUK Beatson Institute, Garscube Estate, Switchback Road, Glasgow, G61 1BD, UK.
Cassidy JW; CRUK Cambridge Institute, University of Cambridge, Robinson Way, Cambridge, CB2 ORE, UK.
Fey SK; CRUK Beatson Institute, Garscube Estate, Switchback Road, Glasgow, G61 1BD, UK.; Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Glasgow, G61 1QH, UK.
Najumudeen AK; CRUK Beatson Institute, Garscube Estate, Switchback Road, Glasgow, G61 1BD, UK.
Zeiger LB; CRUK Beatson Institute, Garscube Estate, Switchback Road, Glasgow, G61 1BD, UK.; Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Glasgow, G61 1QH, UK.
Vincent DF; CRUK Beatson Institute, Garscube Estate, Switchback Road, Glasgow, G61 1BD, UK.
Gay DM; CRUK Beatson Institute, Garscube Estate, Switchback Road, Glasgow, G61 1BD, UK.
Johansson J; CRUK Beatson Institute, Garscube Estate, Switchback Road, Glasgow, G61 1BD, UK.
Fordham RP; CRUK Beatson Institute, Garscube Estate, Switchback Road, Glasgow, G61 1BD, UK.
Miller B; CRUK Beatson Institute, Garscube Estate, Switchback Road, Glasgow, G61 1BD, UK.
Clark W; CRUK Beatson Institute, Garscube Estate, Switchback Road, Glasgow, G61 1BD, UK.
Hedley A; CRUK Beatson Institute, Garscube Estate, Switchback Road, Glasgow, G61 1BD, UK.
Unal EB; EMBL/CRG Systems Biology Research Unit, Centre for Genomic Regulation (CRC), Barcelona, Spain.; Universitat Pompeu Fabra (UPF), 08003, Barcelona, Spain.; Institute for Theoretical Biology, Humboldt Universität zu Berlin, Berlin, Germany.
Kiel C; EMBL/CRG Systems Biology Research Unit, Centre for Genomic Regulation (CRC), Barcelona, Spain.
McGhee E; CRUK Beatson Institute, Garscube Estate, Switchback Road, Glasgow, G61 1BD, UK.
Machesky LM; CRUK Beatson Institute, Garscube Estate, Switchback Road, Glasgow, G61 1BD, UK.; Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Glasgow, G61 1QH, UK.
Nixon C; CRUK Beatson Institute, Garscube Estate, Switchback Road, Glasgow, G61 1BD, UK.
Johnsson AE; The Babraham Institute, Babraham Hall, Babraham, Cambridge, CB22 3AT, UK.
Bain M; IBAHCM and School of Veterinary Medicine, 464 Bearsden Road, Bearsden, Glasgow, G61 1QH, UK.
Strathdee D; CRUK Beatson Institute, Garscube Estate, Switchback Road, Glasgow, G61 1BD, UK.
van Hoof SR; Laboratory for Experimental Oncology and Radiobiology (LEXOR), Center for Experimental Molecular Medicine (CEMM) and Cancer Center Amsterdam, Academic Medical Center, Amsterdam, The Netherlands.; Oncode Institute, Academic Medical Center, Amsterdam, The Netherlands.
Medema JP; Laboratory for Experimental Oncology and Radiobiology (LEXOR), Center for Experimental Molecular Medicine (CEMM) and Cancer Center Amsterdam, Academic Medical Center, Amsterdam, The Netherlands.; Oncode Institute, Academic Medical Center, Amsterdam, The Netherlands.
Anderson KI; The Francis Crick Institute, Mill Hill Laboratory, London, NW7 1AA, UK.
Brachmann SM; Novartis Institutes for BioMedical Research, Klybeckstrasse, 141, 4002, Basel, Switzerland.
Stucke VM; Novartis Institutes for BioMedical Research, Klybeckstrasse, 141, 4002, Basel, Switzerland.
Malliri A; CRUK Manchester Institute, 553 Wilmslow Road, Manchester, M20 4BX, UK.
Drysdale M; Broad Institute, 415 Main St, Cambridge, MA, 02142, United States.
Turner M; The Babraham Institute, Babraham Hall, Babraham, Cambridge, CB22 3AT, UK.
Serrano L; EMBL/CRG Systems Biology Research Unit, Centre for Genomic Regulation (CRC), Barcelona, Spain.
Myant K; Edinburgh Research Centre, The Institute of Genetics and Molecular Medicine, Crewe Road South, Edinburgh, EH4 2XR, UK. .
Campbell AD; CRUK Beatson Institute, Garscube Estate, Switchback Road, Glasgow, G61 1BD, UK. .
Sansom OJ; CRUK Beatson Institute, Garscube Estate, Switchback Road, Glasgow, G61 1BD, UK. .; Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Glasgow, G61 1QH, UK. .
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Źródło :
Nature communications [Nat Commun] 2021 Jan 04; Vol. 12 (1), pp. 56. Date of Electronic Publication: 2021 Jan 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Signal Transduction*
Carcinogenesis/*metabolism
Carcinogenesis/*pathology
Guanine Nucleotide Exchange Factors/*metabolism
Intestines/*pathology
rac1 GTP-Binding Protein/*metabolism
Adenomatous Polyposis Coli Protein/metabolism ; Animals ; Carcinogenesis/genetics ; Homeostasis ; Intestines/ultrastructure ; Mice, Knockout ; Mutation/genetics ; Organ Specificity ; Phenotype ; Proto-Oncogene Proteins c-vav/metabolism ; Proto-Oncogene Proteins p21(ras)/genetics ; T-Lymphoma Invasion and Metastasis-inducing Protein 1/metabolism ; Up-Regulation ; Wnt Signaling Pathway
Czasopismo naukowe
Tytuł :
Capsaicin lacks tumor-promoting effects during colon carcinogenesis in a rat model induced by 1,2-dimethylhydrazine.
Autorzy :
Caetano BFR; Department of Pathology, Medical School, São Paulo State University (UNESP), Botucatu, SP, Brazil.
Tablas MB; Department of Structural and Functional Biology, Biosciences Institute, São Paulo State University (UNESP), Botucatu, SP, 18618-689, Brazil.
Ignoti MG; Department of Structural and Functional Biology, Biosciences Institute, São Paulo State University (UNESP), Botucatu, SP, 18618-689, Brazil.
de Moura NA; Department of Structural and Functional Biology, Biosciences Institute, São Paulo State University (UNESP), Botucatu, SP, 18618-689, Brazil.
Romualdo GR; Department of Structural and Functional Biology, Biosciences Institute, São Paulo State University (UNESP), Botucatu, SP, 18618-689, Brazil.
Barbisan LF; Department of Structural and Functional Biology, Biosciences Institute, São Paulo State University (UNESP), Botucatu, SP, 18618-689, Brazil. .
Rodrigues MAM; Department of Pathology, Medical School, São Paulo State University (UNESP), Botucatu, SP, Brazil.
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Źródło :
Environmental science and pollution research international [Environ Sci Pollut Res Int] 2021 Jan; Vol. 28 (2), pp. 2457-2467. Date of Electronic Publication: 2020 Sep 04.
Typ publikacji :
Journal Article
MeSH Terms :
Capsaicin*/pharmacology
Carcinogenesis*
1,2-Dimethylhydrazine/toxicity ; Animals ; Carcinogens/toxicity ; Rats ; Rats, Wistar
Czasopismo naukowe
Tytuł :
DYRK1A: a down syndrome-related dual protein kinase with a versatile role in tumorigenesis.
Autorzy :
Laham AJ; College of Medicine, University of Sharjah, Sharjah, UAE.; Sharjah Institute for Medical Research, University of Sharjah, Sharjah, UAE.
Saber-Ayad M; College of Medicine, University of Sharjah, Sharjah, UAE. .; Sharjah Institute for Medical Research, University of Sharjah, Sharjah, UAE. .
El-Awady R; College of Medicine, University of Sharjah, Sharjah, UAE. .; College of Pharmacy, University of Sharjah, Sharjah, UAE. .
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Źródło :
Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2021 Jan; Vol. 78 (2), pp. 603-619. Date of Electronic Publication: 2020 Sep 01.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Carcinogenesis/*metabolism
Down Syndrome/*metabolism
Neoplasms/*metabolism
Protein-Serine-Threonine Kinases/*metabolism
Protein-Tyrosine Kinases/*metabolism
Animals ; Apoptosis ; Carcinogenesis/genetics ; DNA Damage ; DNA Repair ; Down Syndrome/genetics ; Gene Expression Regulation, Neoplastic ; Humans ; Neoplasms/genetics ; Protein-Serine-Threonine Kinases/genetics ; Protein-Tyrosine Kinases/genetics ; Signal Transduction ; Up-Regulation
Czasopismo naukowe
Tytuł :
Matrix stiffness epigenetically regulates the oncogenic activation of the Yes-associated protein in gastric cancer.
Autorzy :
Jang M; Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea.
An J; Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea.
Oh SW; Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea.
Lim JY; Department of Surgery, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
Kim J; Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea.
Choi JK; Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea. .
Cheong JH; Department of Surgery, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea. .
Kim P; Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea. .; Institute for Health Science and Technology, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea. .
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Źródło :
Nature biomedical engineering [Nat Biomed Eng] 2021 Jan; Vol. 5 (1), pp. 114-123. Date of Electronic Publication: 2020 Dec 07.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adaptor Proteins, Signal Transducing*/genetics
Adaptor Proteins, Signal Transducing*/metabolism
Carcinogenesis*/genetics
Carcinogenesis*/metabolism
DNA Methylation*/genetics
DNA Methylation*/physiology
Extracellular Matrix*/chemistry
Extracellular Matrix*/genetics
Extracellular Matrix*/metabolism
Stomach Neoplasms*/genetics
Stomach Neoplasms*/metabolism
Stomach Neoplasms*/physiopathology
Transcription Factors*/genetics
Transcription Factors*/metabolism
Cell Line, Tumor ; Epigenesis, Genetic/genetics ; Epigenesis, Genetic/physiology ; Humans ; Mechanotransduction, Cellular/genetics ; Mechanotransduction, Cellular/physiology ; Tumor Microenvironment/genetics ; Tumor Microenvironment/physiology
Czasopismo naukowe
Tytuł :
A pan-cancer analysis of molecular characteristics and oncogenic role of hexokinase family genes in human tumors.
Autorzy :
Jiang M; Department of Urology, The First Hospital of China Medical University, Shenyang 110001, China.
Liu S; Department of Urology, The First Hospital of China Medical University, Shenyang 110001, China. Electronic address: .
Lin J; Department of Urology, The First Hospital of China Medical University, Shenyang 110001, China.
Hao W; Department of Urology, The First Hospital of China Medical University, Shenyang 110001, China. Electronic address: .
Wei B; Department of Urology, The First Hospital of China Medical University, Shenyang 110001, China.
Gao Y; Department of Urology, The First Hospital of China Medical University, Shenyang 110001, China.
Kong C; Department of Urology, The First Hospital of China Medical University, Shenyang 110001, China.
Yu M; Department of Urology, The First Hospital of China Medical University, Shenyang 110001, China; Department of Reproductive Biology and Transgenic Animal, China Medical University, Shenyang 110001, China. Electronic address: .
Zhu Y; Department of Urology, The First Hospital of China Medical University, Shenyang 110001, China. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Jan 01; Vol. 264, pp. 118669. Date of Electronic Publication: 2020 Oct 26.
Typ publikacji :
Journal Article
MeSH Terms :
Biomarkers, Tumor/*genetics
Carcinogenesis/*genetics
Gene Regulatory Networks/*physiology
Hexokinase/*genetics
Neoplasms/*genetics
Oncogenes/*physiology
Biomarkers, Tumor/metabolism ; Carcinogenesis/metabolism ; Carcinogenesis/pathology ; Cell Line, Tumor ; Hexokinase/metabolism ; Humans ; Neoplasms/metabolism ; Neoplasms/pathology
Czasopismo naukowe
Tytuł :
LncRNA NBR2 inhibits tumorigenesis by regulating autophagy in hepatocellular carcinoma.
Autorzy :
Sheng JQ; Division of Gastroenterology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address: .
Wang MR; Division of Gastroenterology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address: .
Fang D; Division of Gastroenterology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address: .
Liu L; Division of Gastroenterology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address: .
Huang WJ; Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Clinical Medical Research Center of Hepatic Surgery at Hubei Province, Wuhan, China. Electronic address: .
Tian DA; Division of Gastroenterology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address: .
He XX; Division of Gastroenterology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address: .
Li PY; Division of Gastroenterology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address: .
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Źródło :
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2021 Jan; Vol. 133, pp. 111023. Date of Electronic Publication: 2020 Dec 01.
Typ publikacji :
Journal Article
MeSH Terms :
Autophagy*
Carcinogenesis/*metabolism
Carcinoma, Hepatocellular/*metabolism
Liver Neoplasms/*metabolism
RNA, Long Noncoding/*metabolism
Animals ; Beclin-1/genetics ; Beclin-1/metabolism ; Carcinogenesis/genetics ; Carcinogenesis/pathology ; Carcinoma, Hepatocellular/genetics ; Carcinoma, Hepatocellular/pathology ; Cell Movement ; Cell Proliferation ; Extracellular Signal-Regulated MAP Kinases/metabolism ; Gene Expression Regulation, Neoplastic ; Hep G2 Cells ; Humans ; JNK Mitogen-Activated Protein Kinases/metabolism ; Liver Neoplasms/genetics ; Liver Neoplasms/pathology ; Male ; Mice, Inbred BALB C ; Mice, Nude ; Neoplasm Invasiveness ; RNA, Long Noncoding/genetics ; Signal Transduction
Czasopismo naukowe
Tytuł :
Aberrations of m6A regulators are associated with tumorigenesis and metastasis in head and neck squamous cell carcinoma.
Autorzy :
Arumugam P; Cellular and Molecular Research Centre, Saveetha Dental College & Hospital, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai, India. Electronic address: .
George R; Department of Oral Oncology, Saveetha Dental College & Hospital, Saveetha Institute of Medical and Technical Sciences [SIMATS], Saveetha University, Chennai, India.
Jayaseelan VP; Cellular and Molecular Research Centre, Saveetha Dental College & Hospital, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai, India.
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Źródło :
Archives of oral biology [Arch Oral Biol] 2021 Feb; Vol. 122, pp. 105030. Date of Electronic Publication: 2020 Dec 28.
Typ publikacji :
Journal Article
MeSH Terms :
Carcinogenesis*/genetics
Head and Neck Neoplasms*/genetics
Adenosine/*analogs & derivatives
RNA-Binding Proteins/*genetics
Squamous Cell Carcinoma of Head and Neck/*genetics
Adenosine/genetics ; Cell Transformation, Neoplastic ; Gene Expression Regulation, Neoplastic ; Humans ; RNA, Messenger
Czasopismo naukowe
Tytuł :
The oncogenicity of tumor-derived mutant p53 is enhanced by the recruitment of PLK3.
Autorzy :
Vaughan CA; Philips Institute, Virginia Commonwealth University, Richmond, VA, 23298, USA.
Singh S; Philips Institute, Virginia Commonwealth University, Richmond, VA, 23298, USA.
Subler MA; Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, VA, 23298, USA.
Windle JJ; Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, VA, 23298, USA.
Inoue K; Department of Pathology, Wake Forest School of Medicine, Winston-Salem, NC, 27101, USA.
Fry EA; Department of Pathology, Wake Forest School of Medicine, Winston-Salem, NC, 27101, USA.
Pillappa R; Department of Pathology, Virginia Commonwealth University, Richmond, VA, 23298, USA.
Grossman SR; Massey Cancer Center, Virginia Commonwealth University, Richmond, VA, 23298, USA.; Department of Internal Medicine, Division of Hematology, Oncology and Palliative Care, Virginia Commonwealth University, Richmond, VA, 23298, USA.
Windle B; Philips Institute, Virginia Commonwealth University, Richmond, VA, 23298, USA.; Massey Cancer Center, Virginia Commonwealth University, Richmond, VA, 23298, USA.
Andrew Yeudall W; Department of Oral Biology & Diagnostic Sciences, Augusta University, Augusta, GA, 30912, USA.; Georgia Cancer Center, Augusta University, Augusta, GA, 30912, USA.
Deb SP; Massey Cancer Center, Virginia Commonwealth University, Richmond, VA, 23298, USA.; Department of Biochemistry & Molecular Biology, Virginia Commonwealth University, Richmond, VA, 23298, USA.
Deb S; Massey Cancer Center, Virginia Commonwealth University, Richmond, VA, 23298, USA. .; Department of Biochemistry & Molecular Biology, Virginia Commonwealth University, Richmond, VA, 23298, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Jan 29; Vol. 12 (1), pp. 704. Date of Electronic Publication: 2021 Jan 29.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Carcinogenesis/*genetics
Lung Neoplasms/*genetics
Protein-Serine-Threonine Kinases/*metabolism
Tumor Suppressor Protein p53/*genetics
Animals ; Carcinogenesis/pathology ; Cell Line, Tumor ; Disease Models, Animal ; Female ; Gain of Function Mutation ; Gene Knock-In Techniques ; Gene Knockout Techniques ; Humans ; Lung/pathology ; Lung Neoplasms/pathology ; Mice ; Mice, Transgenic ; Phosphorylation/genetics ; Protein Domains/genetics ; Protein-Serine-Threonine Kinases/genetics ; Serine/metabolism ; Spheroids, Cellular ; Transcriptional Activation ; Tumor Suppressor Protein p53/metabolism
Czasopismo naukowe
Tytuł :
The circadian cryptochrome, CRY1, is a pro-tumorigenic factor that rhythmically modulates DNA repair.
Autorzy :
Shafi AA; Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA, 19107, USA.
McNair CM; Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA, 19107, USA.; Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, 19107, USA.
McCann JJ; Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA, 19107, USA.; Duke University, Durham, NC, 27708, USA.
Alshalalfa M; Department of Radiation Oncology, University of California at San Francisco, San Francisco, CA, 94115, USA.
Shostak A; Biochemistry Center, University of Heidelberg, Heidelberg, Germany.
Severson TM; Division of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Zhu Y; Division of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Bergman A; Division of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Gordon N; Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA, 19107, USA.
Mandigo AC; Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA, 19107, USA.
Chand SN; Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA, 19107, USA.
Gallagher P; Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA, 19107, USA.
Dylgjeri E; Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA, 19107, USA.
Laufer TS; Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA, 19107, USA.
Vasilevskaya IA; Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA, 19107, USA.
Schiewer MJ; Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA, 19107, USA.; Department of Urology, Medical Oncology and Radiation Oncology, Thomas Jefferson University, Philadelphia, PA, USA.
Brunner M; Biochemistry Center, University of Heidelberg, Heidelberg, Germany.
Feng FY; Department of Radiation Oncology, University of California at San Francisco, San Francisco, CA, 94115, USA.
Zwart W; Division of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Knudsen KE; Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA, 19107, USA. .; Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, 19107, USA. .; Department of Urology, Medical Oncology and Radiation Oncology, Thomas Jefferson University, Philadelphia, PA, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Jan 15; Vol. 12 (1), pp. 401. Date of Electronic Publication: 2021 Jan 15.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation, Neoplastic*
Carcinogenesis/*genetics
Cryptochromes/*metabolism
Prostatic Neoplasms, Castration-Resistant/*genetics
Recombinational DNA Repair/*genetics
Aged ; Androgen Receptor Antagonists/pharmacology ; Androgen Receptor Antagonists/therapeutic use ; Androgens/metabolism ; Carcinogenesis/drug effects ; Cell Line, Tumor ; Chromatin Immunoprecipitation Sequencing ; Cryptochromes/genetics ; DNA Breaks, Double-Stranded/drug effects ; Datasets as Topic ; Disease Progression ; Follow-Up Studies ; G2 Phase Cell Cycle Checkpoints/genetics ; Humans ; Male ; Middle Aged ; Neoplasm Grading ; Promoter Regions, Genetic/genetics ; Prospective Studies ; Prostate/pathology ; Prostate/surgery ; Prostatectomy ; Prostatic Neoplasms, Castration-Resistant/mortality ; Prostatic Neoplasms, Castration-Resistant/pathology ; Prostatic Neoplasms, Castration-Resistant/therapy ; RNA-Seq ; Receptors, Androgen/metabolism ; Recombinational DNA Repair/drug effects ; Retrospective Studies
Czasopismo naukowe
Tytuł :
Interaction between SNAI2 and MYOD enhances oncogenesis and suppresses differentiation in Fusion Negative Rhabdomyosarcoma.
Autorzy :
Pomella S; Department of Pediatric Hematology and Oncology, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.; Genetics Branch, NCI, NIH, Bethesda, MD, USA.
Sreenivas P; Greehey Children's Cancer Research Institute, Department of Molecular Medicine, University of Texas Health Sciences Center, San Antonio, Texas, USA.
Gryder BE; Genetics Branch, NCI, NIH, Bethesda, MD, USA.
Wang L; Greehey Children's Cancer Research Institute, Department of Molecular Medicine, University of Texas Health Sciences Center, San Antonio, Texas, USA.
Milewski D; Genetics Branch, NCI, NIH, Bethesda, MD, USA.
Cassandri M; Department of Pediatric Hematology and Oncology, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Baxi K; Greehey Children's Cancer Research Institute, Department of Molecular Medicine, University of Texas Health Sciences Center, San Antonio, Texas, USA.
Hensch NR; Greehey Children's Cancer Research Institute, Department of Molecular Medicine, University of Texas Health Sciences Center, San Antonio, Texas, USA.
Carcarino E; Department of Pediatric Hematology and Oncology, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Song Y; Genetics Branch, NCI, NIH, Bethesda, MD, USA.
Chou HC; Genetics Branch, NCI, NIH, Bethesda, MD, USA.
Yohe ME; Genetics Branch, NCI, NIH, Bethesda, MD, USA.; Pediatric Oncology Branch, NCI, NIH, Bethesda, MD, USA.
Stanton BZ; Center for Childhood Cancer and Blood Diseases, Abigail Wexner Research Institute at Nationwide Children's Hospital, The Ohio State University, Columbus, OH, 43205, USA.
Amadio B; SAFU Laboratory, Translational Research Area, Regina Elena National Cancer Institute, Rome, Italy.
Caruana I; Department of Pediatric Hematology and Oncology, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
De Stefanis C; Histology-Core Facility, Bambino Gesu' Children's Hospital, IRCCS, Rome, Italy.
De Vito R; Department of Pathology Unit, Department of Laboratories, Bambino Gesu' Children's Hospital, IRCCS, Rome, Italy.
Locatelli F; Department of Pediatric Hematology and Oncology, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.; Departmentof Pediatrics, Sapienza University of Rome, Rome, Italy.
Chen Y; Greehey Children's Cancer Research Institute, Department of Molecular Medicine, University of Texas Health Sciences Center, San Antonio, Texas, USA.
Chen EY; Department of Pathology, University of Washington, Seattle, WA, 98195, USA.
Houghton P; Greehey Children's Cancer Research Institute, Department of Molecular Medicine, University of Texas Health Sciences Center, San Antonio, Texas, USA.
Khan J; Genetics Branch, NCI, NIH, Bethesda, MD, USA. .
Rota R; Department of Pediatric Hematology and Oncology, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy. .
Ignatius MS; Greehey Children's Cancer Research Institute, Department of Molecular Medicine, University of Texas Health Sciences Center, San Antonio, Texas, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Jan 08; Vol. 12 (1), pp. 192. Date of Electronic Publication: 2021 Jan 08.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Cell Differentiation*/genetics
Carcinogenesis/*metabolism
MyoD Protein/*metabolism
Oncogene Proteins, Fusion/*metabolism
Rhabdomyosarcoma/*genetics
Rhabdomyosarcoma/*metabolism
Snail Family Transcription Factors/*metabolism
Animals ; Carcinogenesis/genetics ; Cell Line, Tumor ; Cyclin-Dependent Kinase Inhibitor p21/metabolism ; Female ; Gene Expression Regulation, Neoplastic ; Gene Knockdown Techniques ; Heterografts ; Humans ; MEF2 Transcription Factors/metabolism ; Male ; Mice ; Mice, SCID ; Muscle Development/genetics ; MyoD Protein/genetics ; Myogenin/metabolism ; Oncogene Proteins, Fusion/genetics ; Oncogenes ; Rhabdomyosarcoma/pathology ; Rhabdomyosarcoma, Alveolar/genetics ; Rhabdomyosarcoma, Embryonal/genetics ; Snail Family Transcription Factors/genetics ; Transcriptome
Czasopismo naukowe
Tytuł :
[Calcium-activated chloride channels: structure, properties, role in physiological and pathological processes].
Autorzy :
Grigoriev VV; Institute of Physiologically Active Compounds of the Russian Academy of Sciences, Moscow, Russia.
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Transliterated Title :
Kal'tsiĭ-aktiviruemye khlornye kanaly: stroenie, svoĭstva, rol' v fiziologicheskikh i patologicheskikh protsessakh.
Źródło :
Biomeditsinskaia khimiia [Biomed Khim] 2021 Jan; Vol. 67 (1), pp. 17-33.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Carcinogenesis*
Chloride Channels*/genetics
Anoctamin-1 ; Anoctamins ; Calcium/metabolism ; Humans
Czasopismo naukowe
Tytuł :
Notch Signaling and Human Papillomavirus-Associated Oral Tumorigenesis.
Autorzy :
Das T; Department of Radiation and Cellular Oncology, University of Chicago, Chicago, IL, USA.
Zhong R; Department of Radiation and Cellular Oncology, University of Chicago, Chicago, IL, USA.
Spiotto MT; Department of Radiation and Cellular Oncology, University of Chicago, Chicago, IL, USA. .; Department of Radiation Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA. .
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Źródło :
Advances in experimental medicine and biology [Adv Exp Med Biol] 2021; Vol. 1287, pp. 105-122.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Carcinogenesis*
Signal Transduction*
Mouth Neoplasms/*metabolism
Mouth Neoplasms/*virology
Papillomaviridae/*pathogenicity
Papillomavirus Infections/*metabolism
Receptors, Notch/*metabolism
Animals ; Carcinoma, Squamous Cell/metabolism ; Carcinoma, Squamous Cell/virology ; Humans ; Papillomavirus Infections/virology
Czasopismo naukowe
Tytuł :
EGR1-mediated linc01503 promotes cell cycle progression and tumorigenesis in gastric cancer.
Autorzy :
Ma Z; Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Division of Gastrointestinal Cancer Translational Research Laboratory, Peking University Cancer Hospital and Institute, Beijing, China.
Gao X; Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Division of Gastrointestinal Cancer Translational Research Laboratory, Peking University Cancer Hospital and Institute, Beijing, China.
Shuai Y; Department of Medical Oncology, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, The Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, China.
Wu X; Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Division of Gastrointestinal Cancer Translational Research Laboratory, Peking University Cancer Hospital and Institute, Beijing, China.
Yan Y; Department of Endoscopy Center, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital and Institute, Beijing, China.
Xing X; Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Division of Gastrointestinal Cancer Translational Research Laboratory, Peking University Cancer Hospital and Institute, Beijing, China.
Ji J; Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Division of Gastrointestinal Cancer Translational Research Laboratory, Peking University Cancer Hospital and Institute, Beijing, China.
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Źródło :
Cell proliferation [Cell Prolif] 2021 Jan; Vol. 54 (1), pp. e12922. Date of Electronic Publication: 2020 Nov 03.
Typ publikacji :
Journal Article
MeSH Terms :
Carcinogenesis*
Cell Cycle*
Early Growth Response Protein 1/*metabolism
RNA, Long Noncoding/*metabolism
Stomach Neoplasms/*metabolism
Animals ; Cell Line, Tumor ; Early Growth Response Protein 1/genetics ; Humans ; Mice ; Mice, Nude ; Neoplasms, Experimental/metabolism ; Neoplasms, Experimental/pathology ; RNA, Long Noncoding/genetics ; Stomach Neoplasms/pathology
Czasopismo naukowe
Tytuł :
Reserpine inhibits DNA repair, cell proliferation, invasion and induces apoptosis in oral carcinogenesis via modulation of TGF-β signaling.
Autorzy :
Ramu AK; Department of Biochemistry and Biotechnology, Centre for Research and Development, PRIST Deemed University, Vallam, Thanjavur, Tamil Nadu, India. Electronic address: .
Ali D; Department of Zoology, College of Science King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia.
Alarifi S; Department of Zoology, College of Science King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia.
Syed Abuthakir MH; Biochematics Lab, Department of Bioinformatics, Bharathiar University, Coimbatore, India.
Ahmed Abdul BA; Department of Biochemistry and Biotechnology, Centre for Research and Development, PRIST Deemed University, Vallam, Thanjavur, Tamil Nadu, India. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Jan 01; Vol. 264, pp. 118730. Date of Electronic Publication: 2020 Nov 06.
Typ publikacji :
Journal Article
MeSH Terms :
Signal Transduction*/drug effects
Apoptosis/*drug effects
Carcinogenesis/*pathology
DNA Repair/*drug effects
Mouth Neoplasms/*pathology
Reserpine/*pharmacology
Transforming Growth Factor beta/*metabolism
9,10-Dimethyl-1,2-benzanthracene ; Animals ; Carcinogenesis/drug effects ; Cell Proliferation/drug effects ; Cricetinae ; Down-Regulation/drug effects ; Down-Regulation/genetics ; Male ; Molecular Docking Simulation ; Mouth Mucosa/drug effects ; Mouth Mucosa/pathology ; Neoplasm Invasiveness ; Neoplasm Proteins/metabolism ; Reserpine/chemistry
Czasopismo naukowe

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