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Tytuł :
Wedelolactone ameliorates Pseudomonas aeruginosa-induced inflammation and corneal injury by suppressing caspase-4/5/11/GSDMD-mediated non-canonical pyroptosis.
Autorzy :
Xu S; Eye Hospital, The First Affiliated Hospital of Harbin Medical University, Heilongjiang Province, PR China; Key Laboratory of Basic and Clinical Research of Heilongjiang Province, PR China.
Liu X; Eye Hospital, The First Affiliated Hospital of Harbin Medical University, Heilongjiang Province, PR China; Key Laboratory of Basic and Clinical Research of Heilongjiang Province, PR China.
Liu X; Eye Hospital, The First Affiliated Hospital of Harbin Medical University, Heilongjiang Province, PR China; Key Laboratory of Basic and Clinical Research of Heilongjiang Province, PR China.
Shi Y; Eye Hospital, The First Affiliated Hospital of Harbin Medical University, Heilongjiang Province, PR China; Key Laboratory of Basic and Clinical Research of Heilongjiang Province, PR China.
Jin X; Eye Hospital, The First Affiliated Hospital of Harbin Medical University, Heilongjiang Province, PR China; Key Laboratory of Basic and Clinical Research of Heilongjiang Province, PR China.
Zhang N; Eye Hospital, The First Affiliated Hospital of Harbin Medical University, Heilongjiang Province, PR China.
Li X; Eye Hospital, The First Affiliated Hospital of Harbin Medical University, Heilongjiang Province, PR China; Key Laboratory of Basic and Clinical Research of Heilongjiang Province, PR China.
Zhang H; Eye Hospital, The First Affiliated Hospital of Harbin Medical University, Heilongjiang Province, PR China; Key Laboratory of Basic and Clinical Research of Heilongjiang Province, PR China. Electronic address: .
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Źródło :
Experimental eye research [Exp Eye Res] 2021 Oct; Vol. 211, pp. 108750. Date of Electronic Publication: 2021 Sep 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Caspases/*metabolism
Corneal Injuries/*prevention & control
Corneal Ulcer/*prevention & control
Coumarins/*therapeutic use
Intracellular Signaling Peptides and Proteins/*metabolism
Phosphate-Binding Proteins/*metabolism
Pyroptosis/*drug effects
Animals ; Blotting, Western ; Caspases, Initiator/metabolism ; Cell Proliferation ; Corneal Injuries/metabolism ; Corneal Injuries/microbiology ; Corneal Ulcer/metabolism ; Corneal Ulcer/microbiology ; Disease Models, Animal ; Enzyme-Linked Immunosorbent Assay ; Eye Infections, Bacterial/metabolism ; Eye Infections, Bacterial/microbiology ; Eye Infections, Bacterial/prevention & control ; Humans ; Interleukin-18/metabolism ; Interleukin-1beta/metabolism ; L-Lactate Dehydrogenase/metabolism ; Male ; Microscopy, Fluorescence ; Pseudomonas Infections/metabolism ; Pseudomonas Infections/microbiology ; Pseudomonas Infections/prevention & control ; Pseudomonas aeruginosa ; Rats, Sprague-Dawley ; Real-Time Polymerase Chain Reaction
Czasopismo naukowe
Tytuł :
Irgm2 and Gate-16 cooperatively dampen Gram-negative bacteria-induced caspase-11 response.
Autorzy :
Eren E; Institute of Pharmacology and Structural Biology (IPBS), CNRS, UMR5089, University of Toulouse, Toulouse, France.
Planès R; Institute of Pharmacology and Structural Biology (IPBS), CNRS, UMR5089, University of Toulouse, Toulouse, France.
Bagayoko S; Institute of Pharmacology and Structural Biology (IPBS), CNRS, UMR5089, University of Toulouse, Toulouse, France.
Bordignon PJ; Institute of Pharmacology and Structural Biology (IPBS), CNRS, UMR5089, University of Toulouse, Toulouse, France.
Chaoui K; Institute of Pharmacology and Structural Biology (IPBS), CNRS, UMR5089, University of Toulouse, Toulouse, France.; Mass Spectrometry Core Facility, Institute of Pharmacology and Structural Biology (IPBS), CNRS, UMR5089, University of Toulouse, Toulouse, France.
Hessel A; Institute of Pharmacology and Structural Biology (IPBS), CNRS, UMR5089, University of Toulouse, Toulouse, France.
Santoni K; Institute of Pharmacology and Structural Biology (IPBS), CNRS, UMR5089, University of Toulouse, Toulouse, France.
Pinilla M; Institute of Pharmacology and Structural Biology (IPBS), CNRS, UMR5089, University of Toulouse, Toulouse, France.
Lagrange B; CIRI, Centre International de Recherche en Infectiologie, Inserm, U1111, CNRS, UMR5308, École Normale Supérieure de Lyon, Université Claude Bernard Lyon 1, Univ Lyon, Lyon, France.
Burlet-Schiltz O; Institute of Pharmacology and Structural Biology (IPBS), CNRS, UMR5089, University of Toulouse, Toulouse, France.; Mass Spectrometry Core Facility, Institute of Pharmacology and Structural Biology (IPBS), CNRS, UMR5089, University of Toulouse, Toulouse, France.
Howard JC; Fundação Calouste Gulbenkian, Instituto Gulbenkian de Ciência, Oeiras, Portugal.
Henry T; CIRI, Centre International de Recherche en Infectiologie, Inserm, U1111, CNRS, UMR5308, École Normale Supérieure de Lyon, Université Claude Bernard Lyon 1, Univ Lyon, Lyon, France.
Yamamoto M; Department of Immunoparasitology, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan.; Laboratory of Immunoparasitology, WPI Immunology Frontier Research Center, Osaka University, Osaka, Japan.
Meunier E; Institute of Pharmacology and Structural Biology (IPBS), CNRS, UMR5089, University of Toulouse, Toulouse, France.
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Źródło :
EMBO reports [EMBO Rep] 2020 Nov 05; Vol. 21 (11), pp. e50829. Date of Electronic Publication: 2020 Oct 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Caspases*/genetics
Lipopolysaccharides*
Autophagy-Related Protein 8 Family ; Caspases, Initiator ; Gram-Negative Bacteria ; Inflammasomes/genetics ; Macrophages
Czasopismo naukowe
Tytuł :
Pyroptotic and non-pyroptotic effector functions of caspase-11.
Autorzy :
Abu Khweek A; Department of Biology and Biochemistry, Birzeit University, West Bank, Palestine.
Amer AO; Department of Microbial Infection and Immunity, Infectious Disease Institute, College of Medicine, The Ohio State University, Columbus, OH, USA.
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Źródło :
Immunological reviews [Immunol Rev] 2020 Sep; Vol. 297 (1), pp. 39-52. Date of Electronic Publication: 2020 Aug 01.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Caspases*
Inflammasomes*
Animals ; Caspase 1 ; Caspases, Initiator ; Mice ; Mice, Knockout ; Pyroptosis
Czasopismo naukowe
Tytuł :
A model for the regulation of apoptosis intrinsic pathway: The potential role of the transcriptional regulator E2F in the point of no return.
Autorzy :
Rojas López A; Biophysics and Systems Biology Section, Faculty of Sciences, Universidad de la República, Montevideo, Uruguay.
Monzón P; Systems and Control Department, Faculty of Engineering, Universidad de la República, Montevideo, Uruguay.
Acerenza L; Biophysics and Systems Biology Section, Faculty of Sciences, Universidad de la República, Montevideo, Uruguay. Electronic address: .
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Źródło :
Journal of theoretical biology [J Theor Biol] 2021 Sep 21; Vol. 525, pp. 110765. Date of Electronic Publication: 2021 May 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis*
Caspases*/metabolism
Cytochromes c/metabolism ; Mitochondria ; Mitochondrial Membranes/metabolism
Czasopismo naukowe
Tytuł :
Plant type I metacaspases are proteolytically active proteases despite their hydrophobic nature.
Autorzy :
van Midden KP; Department of Chemistry and Biochemistry, Faculty of Chemistry and Chemical Technology, University of Ljubljana, Slovenia.
Peric T; Department of Chemistry and Biochemistry, Faculty of Chemistry and Chemical Technology, University of Ljubljana, Slovenia.
Klemenčič M; Department of Chemistry and Biochemistry, Faculty of Chemistry and Chemical Technology, University of Ljubljana, Slovenia.
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Źródło :
FEBS letters [FEBS Lett] 2021 Sep; Vol. 595 (17), pp. 2237-2247. Date of Electronic Publication: 2021 Aug 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Caspases/*chemistry
Caspases/*metabolism
Plant Proteins/*chemistry
Plant Proteins/*metabolism
Calcium/metabolism ; Caspases/genetics ; Chlamydomonas reinhardtii/enzymology ; Escherichia coli/genetics ; Hydrophobic and Hydrophilic Interactions ; Peptide Hydrolases/chemistry ; Peptide Hydrolases/metabolism ; Plant Proteins/genetics ; Protein Domains ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Serpins/metabolism
Czasopismo naukowe
Tytuł :
Evidence for the involvement of caspases in establishing proper cerebrospinal fluid hydrodynamics.
Autorzy :
Yoshida A; Department of Genetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan.
Kawata D; Department of Genetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan.
Shinotsuka N; Department of Genetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan.
Yoshida M; Department of Genetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan.
Yamaguchi Y; Department of Genetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan; Hibernation Metabolism, Physiology, and Development Group, Institute of Low Temperature Science, Hokkaido University, Sapporo, Hokkaido 060-0819, Japan; Global Station for Biosurfaces and Drug Discovery, Hokkaido University, Sapporo, Hokkaido 060-0812, Japan. Electronic address: .
Miura M; Department of Genetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan. Electronic address: .
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Źródło :
Neuroscience research [Neurosci Res] 2021 Sep; Vol. 170, pp. 145-153. Date of Electronic Publication: 2021 Jan 06.
Typ publikacji :
Journal Article
MeSH Terms :
Caspases*
Hydrodynamics*
Animals ; Apoptosis ; Caspase Inhibitors ; Mice ; Mice, Transgenic
Czasopismo naukowe
Tytuł :
Caspase activity in post mortem muscle and its relation to cattle handling practices.
Autorzy :
Fuente-García C; Instituto de Agroquímica y Tecnología de Alimentos (CSIC), Calle del Catedràtic Agustín Escardino Benlloch 7, Paterna, Valencia, 46980, Spain.; Lactiker Research Group, Department of Pharmacy and Food Sciences, University of the Basque Country (UPV-EHU), Paseo de la Universidad 7, Vitoria-Gasteiz, 01006, Spain.
Aldai N; Lactiker Research Group, Department of Pharmacy and Food Sciences, University of the Basque Country (UPV-EHU), Paseo de la Universidad 7, Vitoria-Gasteiz, 01006, Spain.
Sentandreu E; Instituto de Agroquímica y Tecnología de Alimentos (CSIC), Calle del Catedràtic Agustín Escardino Benlloch 7, Paterna, Valencia, 46980, Spain.
Oliván M; Servicio Regional de Investigación y Desarrollo Alimentario (SERIDA), Apdo 13, Villaviciosa, Asturias, 33300, Spain.
Franco D; Centro Tecnológico de la Carne (CETECA), Rúa Galicia 4, San Cibrao das Viñas, Ourense, 32900, Spain.
García-Torres S; Centro de Investigaciones Científicas y Tecnológicas de Extremadura (CICYTEX), Autovía A5, P.K. 372, Guadajira, Badajoz, 06187, Spain.
R Barron LJ; Lactiker Research Group, Department of Pharmacy and Food Sciences, University of the Basque Country (UPV-EHU), Paseo de la Universidad 7, Vitoria-Gasteiz, 01006, Spain.
Sentandreu MÁ; Instituto de Agroquímica y Tecnología de Alimentos (CSIC), Calle del Catedràtic Agustín Escardino Benlloch 7, Paterna, Valencia, 46980, Spain.
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Źródło :
Journal of the science of food and agriculture [J Sci Food Agric] 2021 Dec; Vol. 101 (15), pp. 6258-6264. Date of Electronic Publication: 2021 May 18.
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
Animal Husbandry/*methods
Caspases/*metabolism
Cattle/*metabolism
Meat/*analysis
Muscle, Skeletal/*enzymology
Animals ; Caspases/genetics ; Postmortem Changes
Czasopismo naukowe
Tytuł :
Requirement of Toxoplasma gondii metacaspases for IMC1 maturation, endodyogeny and virulence in mice.
Autorzy :
Li M; National Animal Protozoa Laboratory, College of Veterinary Medicine, China Agricultural University, Beijing, China.; China Animal Health and Epidemiology Center, Qingdao, Shandong, China.
Liu J; National Animal Protozoa Laboratory, College of Veterinary Medicine, China Agricultural University, Beijing, China.; Key Laboratory of Animal Epidemiology of the Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing, China.
Wu Y; National Animal Protozoa Laboratory, College of Veterinary Medicine, China Agricultural University, Beijing, China.
Wu Y; National Animal Protozoa Laboratory, College of Veterinary Medicine, China Agricultural University, Beijing, China.
Sun X; China Animal Health and Epidemiology Center, Qingdao, Shandong, China.
Fu Y; National Animal Protozoa Laboratory, College of Veterinary Medicine, China Agricultural University, Beijing, China.
Zhang X; National Animal Protozoa Laboratory, College of Veterinary Medicine, China Agricultural University, Beijing, China.
Liu Q; National Animal Protozoa Laboratory, College of Veterinary Medicine, China Agricultural University, Beijing, China. .; Key Laboratory of Animal Epidemiology of the Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing, China. .
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Źródło :
Parasites & vectors [Parasit Vectors] 2021 Aug 12; Vol. 14 (1), pp. 400. Date of Electronic Publication: 2021 Aug 12.
Typ publikacji :
Journal Article
MeSH Terms :
Caspases/*metabolism
Protozoan Proteins/*metabolism
Toxoplasma/*enzymology
Toxoplasma/*pathogenicity
Animals ; Caspases/classification ; Caspases/genetics ; Chlorocebus aethiops ; Female ; Fibroblasts/parasitology ; Foreskin/cytology ; Humans ; Male ; Mice ; Mice, Inbred BALB C ; Protozoan Proteins/genetics ; Toxoplasma/genetics ; Toxoplasma/physiology ; Vero Cells ; Virulence
Czasopismo naukowe
Tytuł :
Apoptotic caspases suppress Mycobacterium bovis-induced IFN-β production in murine macrophage.
Autorzy :
Song Y; Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, National Animal Transmissible Spongiform Encephalopathy Laboratory, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China.
Dong Y; Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, National Animal Transmissible Spongiform Encephalopathy Laboratory, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China.
Liao Y; Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, National Animal Transmissible Spongiform Encephalopathy Laboratory, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China; College of Animal & Veterinary Science, Southwest Minzu University, Chengdu, Sichuan 610041, China.
Liang Z; Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, National Animal Transmissible Spongiform Encephalopathy Laboratory, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China.
Yao J; Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, National Animal Transmissible Spongiform Encephalopathy Laboratory, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China.
Zhou X; Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, National Animal Transmissible Spongiform Encephalopathy Laboratory, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China. Electronic address: .
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Źródło :
The Journal of infection [J Infect] 2021 Jul; Vol. 83 (1), pp. 61-68. Date of Electronic Publication: 2021 Apr 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis*
Caspases*/genetics
Mycobacterium bovis*
Interferon-beta/*immunology
Macrophages/*immunology
Animals ; Macrophages/microbiology ; Mice ; Tuberculosis
Czasopismo naukowe
Tytuł :
Caspase-Dependent Cleavage of DDX21 Suppresses Host Innate Immunity.
Autorzy :
Wu W; Department of Avian Infectious Diseases, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Science, Shanghai, People's Republic of China.
Qu Y; College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, People's Republic of China.
Yu S; Department of Avian Infectious Diseases, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Science, Shanghai, People's Republic of China.
Wang S; College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou, People's Republic of China.
Yin Y; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, People's Republic of China.
Liu Q; Department of Avian Infectious Diseases, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Science, Shanghai, People's Republic of China.
Meng C; Department of Avian Infectious Diseases, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Science, Shanghai, People's Republic of China.
Liao Y; Department of Avian Infectious Diseases, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Science, Shanghai, People's Republic of China.
Ur Rehman Z; Department of Avian Infectious Diseases, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Science, Shanghai, People's Republic of China.
Tan L; Department of Avian Infectious Diseases, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Science, Shanghai, People's Republic of China.
Song C; Department of Avian Infectious Diseases, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Science, Shanghai, People's Republic of China.
Qiu X; Department of Avian Infectious Diseases, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Science, Shanghai, People's Republic of China.
Liu W; Department of Avian Infectious Diseases, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Science, Shanghai, People's Republic of China.
Ding C; Department of Avian Infectious Diseases, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Science, Shanghai, People's Republic of China.; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, People's Republic of China.
Sun Y; Department of Avian Infectious Diseases, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Science, Shanghai, People's Republic of China.
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Źródło :
MBio [mBio] 2021 Jun 29; Vol. 12 (3), pp. e0100521. Date of Electronic Publication: 2021 Jun 14.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Immunity, Innate*
Caspases/*metabolism
DEAD-box RNA Helicases/*genetics
DEAD-box RNA Helicases/*immunology
Virus Diseases/*immunology
A549 Cells ; Caspases/classification ; Caspases/genetics ; Cell Line ; Gene Expression Regulation/genetics ; Gene Expression Regulation/immunology ; HEK293 Cells ; HeLa Cells ; Humans ; Interferon-beta/immunology ; Protein Binding ; Signal Transduction/immunology ; THP-1 Cells
Czasopismo naukowe
Tytuł :
Garlic (Allium sativum)-derived SEVs inhibit cancer cell proliferation and induce caspase mediated apoptosis.
Autorzy :
Özkan İ; Department of Genetics and Bioengineering, Faculty of Engineering and Architecture, Yeditepe University, 26 Ağustos Campus, Kayisdagi Cad., Kayisdagi, 34755, Istanbul, Turkey.
Koçak P; Department of Genetics and Bioengineering, Faculty of Engineering and Architecture, Yeditepe University, 26 Ağustos Campus, Kayisdagi Cad., Kayisdagi, 34755, Istanbul, Turkey.
Yıldırım M; Department of Genetics and Bioengineering, Faculty of Engineering and Architecture, Yeditepe University, 26 Ağustos Campus, Kayisdagi Cad., Kayisdagi, 34755, Istanbul, Turkey.
Ünsal N; Department of Genetics and Bioengineering, Faculty of Engineering and Architecture, Yeditepe University, 26 Ağustos Campus, Kayisdagi Cad., Kayisdagi, 34755, Istanbul, Turkey.
Yılmaz H; Department of Genetics and Bioengineering, Faculty of Engineering and Architecture, Yeditepe University, 26 Ağustos Campus, Kayisdagi Cad., Kayisdagi, 34755, Istanbul, Turkey.
Telci D; Department of Genetics and Bioengineering, Faculty of Engineering and Architecture, Yeditepe University, 26 Ağustos Campus, Kayisdagi Cad., Kayisdagi, 34755, Istanbul, Turkey.
Şahin F; Department of Genetics and Bioengineering, Faculty of Engineering and Architecture, Yeditepe University, 26 Ağustos Campus, Kayisdagi Cad., Kayisdagi, 34755, Istanbul, Turkey. .
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Źródło :
Scientific reports [Sci Rep] 2021 Jul 20; Vol. 11 (1), pp. 14773. Date of Electronic Publication: 2021 Jul 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Carcinoma, Renal Cell/*genetics
Caspases/*genetics
Extracellular Vesicles/*transplantation
Garlic/*chemistry
Kidney Neoplasms/*genetics
Lung Neoplasms/*genetics
A549 Cells ; Apoptosis ; Carcinoma, Renal Cell/metabolism ; Caspases/metabolism ; Cell Communication ; Cell Line, Tumor ; Cell Proliferation ; Down-Regulation ; Gene Expression Regulation, Neoplastic ; Humans ; Kidney Neoplasms/metabolism ; Lung Neoplasms/metabolism ; Vascular Endothelial Growth Factor A/metabolism
Czasopismo naukowe
Tytuł :
Pan-caspase inhibition as a potential host-directed immunotherapy against MRSA and other bacterial skin infections.
Autorzy :
Alphonse MP; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
Rubens JH; Divison of Pediatric Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD 21210, USA.
Ortines RV; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
Orlando NA; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
Patel AM; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
Dikeman D; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
Wang Y; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
Vuong I; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
Joyce DP; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
Zhang J; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
Mumtaz M; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
Liu H; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
Liu Q; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
Youn C; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
Patrick GJ; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
Ravipati A; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
Miller RJ; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
Archer NK; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA. .
Miller LS; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA. .
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Źródło :
Science translational medicine [Sci Transl Med] 2021 Jul 07; Vol. 13 (601).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Caspases*
Methicillin-Resistant Staphylococcus aureus*
Animals ; Caspase 1 ; Caspase Inhibitors/pharmacology ; Immunotherapy ; Inflammasomes ; Interleukin-1beta ; Mice ; Tumor Necrosis Factor Inhibitors
Czasopismo naukowe
Tytuł :
Tetrandrine Enhances H 2 O 2 -Induced Apoptotic Cell Death Through Caspase-dependent Pathway in Human Keratinocytes.
Autorzy :
Cheng YC; Department of Biological Science and Technology, China Medical University, Taichung, Taiwan, R.O.C.
Kuo CL; Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung, Taiwan, R.O.C.
Hsu SY; Department of Ophthalmology, An Nan Hospital, China Medical University, Tainan, Taiwan, R.O.C.; Department of Optometry, Chung Hwa University of Medical Technology, Tainan, Taiwan, R.O.C.
Way TD; Department of Biological Science and Technology, China Medical University, Taichung, Taiwan, R.O.C.
Cheng CL; Progam of Digital Health Innovation, China Medical University, Taichung, Taiwan, R.O.C.
Chen JC; Department of Medicinal Botanicals and Health Applications, Da-Yeh University, Changhua, Taiwan, R.O.C.
Liu KC; Department of Medical Laboratory Science and Biotechnology, China Medical University, Taichung, Taiwan, R.O.C.
Peng SF; Department of Biological Science and Technology, China Medical University, Taichung, Taiwan, R.O.C.; Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, R.O.C.
Ho WJ; Department of Medicinal Botanicals and Health Applications, Da-Yeh University, Changhua, Taiwan, R.O.C.
Chueh FS; Department of Food Nutrition and Health Biotechnology, Asia University, Taichung, Taiwan, R.O.C. .
Huang WW; Department of Biological Science and Technology, China Medical University, Taichung, Taiwan, R.O.C.; .
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Źródło :
In vivo (Athens, Greece) [In Vivo] 2021 Jul-Aug; Vol. 35 (4), pp. 2047-2057.
Typ publikacji :
Journal Article
MeSH Terms :
Benzylisoquinolines*/pharmacology
Caspases*/genetics
Apoptosis ; Cell Survival ; Humans ; Hydrogen Peroxide ; Keratinocytes ; Reactive Oxygen Species
Czasopismo naukowe
Tytuł :
Caspase-11/4 and gasdermin D-mediated pyroptosis contributes to podocyte injury in mouse diabetic nephropathy.
Autorzy :
Cheng Q; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, 200032, China.
Pan J; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, 200032, China.
Zhou ZL; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, 200032, China.
Yin F; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, 200032, China.
Xie HY; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, 200032, China.
Chen PP; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, 200032, China.
Li JY; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, 200032, China.
Zheng PQ; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, 200032, China.
Zhou L; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, 200032, China.
Zhang W; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, 200032, China.
Liu J; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, 200032, China. .
Lu LM; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, 200032, China. .
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Źródło :
Acta pharmacologica Sinica [Acta Pharmacol Sin] 2021 Jun; Vol. 42 (6), pp. 954-963. Date of Electronic Publication: 2020 Sep 23.
Typ publikacji :
Journal Article
MeSH Terms :
Caspases, Initiator/*metabolism
Diabetic Nephropathies/*metabolism
Intracellular Signaling Peptides and Proteins/*metabolism
Phosphate-Binding Proteins/*metabolism
Podocytes/*metabolism
Pyroptosis/*physiology
Animals ; Caspases, Initiator/genetics ; Cells, Cultured ; Diabetes Mellitus, Experimental/chemically induced ; Diabetes Mellitus, Experimental/metabolism ; Diabetes Mellitus, Experimental/pathology ; Diabetic Nephropathies/complications ; Diabetic Nephropathies/pathology ; Diet, High-Fat ; Gene Knockout Techniques ; Glucose/pharmacology ; Humans ; Inflammation/etiology ; Inflammation/metabolism ; Inflammation/pathology ; Intracellular Signaling Peptides and Proteins/genetics ; Kidney Glomerulus/pathology ; Macrophages/metabolism ; Male ; Mice, Inbred C57BL ; Phosphate-Binding Proteins/genetics ; Podocytes/drug effects ; Streptozocin
Czasopismo naukowe
Tytuł :
Hippocampal TNF-death receptors, caspase cell death cascades, and IL-8 in alcohol use disorder.
Autorzy :
Liu W; Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599-7178, USA.
Vetreno RP; Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599-7178, USA.
Crews FT; Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599-7178, USA. .
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Źródło :
Molecular psychiatry [Mol Psychiatry] 2021 Jun; Vol. 26 (6), pp. 2254-2262. Date of Electronic Publication: 2020 Mar 05.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Alcoholism*
Caspases*/metabolism
Animals ; Cell Death ; Hippocampus/metabolism ; Humans ; Interleukin-8 ; Rats ; Receptors, Tumor Necrosis Factor/metabolism ; fas Receptor/genetics ; fas Receptor/metabolism
Czasopismo naukowe
Tytuł :
Progesterone induces apoptosis by activation of caspase-8 and calcitriol via activation of caspase-9 pathways in ovarian and endometrial cancer cells in vitro.
Autorzy :
McGlorthan L; Department of Gynecologic Surgery and Obstetrics, Uniformed Services University, Room# A-3080, 4301 Jones Bridge Road, Bethesda, MD, 20814, USA.
Paucarmayta A; Department of Gynecologic Surgery and Obstetrics, Uniformed Services University, Room# A-3080, 4301 Jones Bridge Road, Bethesda, MD, 20814, USA.
Casablanca Y; Department of Gynecologic Surgery and Obstetrics, Uniformed Services University, Room# A-3080, 4301 Jones Bridge Road, Bethesda, MD, 20814, USA.; Department of Obstetrics and Gynecology, Walter Reed National Military Medical Center, 8901 Wisconsin Avenue, Bethesda, MD, 20889, USA.; John P. Murtha Cancer Center, Walter Reed National Military Medical Center, 8901 Wisconsin Avenue, Bethesda, MD, 20889, USA.; Gynecologic Cancer Center of Excellence, Women's Health Integrated Research Center At Inova Health System, 3289 Woodburn Road, Suite 370, Annandale, VA, 22003, USA.
Maxwell GL; John P. Murtha Cancer Center, Walter Reed National Military Medical Center, 8901 Wisconsin Avenue, Bethesda, MD, 20889, USA.; Gynecologic Cancer Center of Excellence, Women's Health Integrated Research Center At Inova Health System, 3289 Woodburn Road, Suite 370, Annandale, VA, 22003, USA.; Department of Obstetrics and Gynecology, Inova Fairfax Hospital, 3300 Gallows Road, Falls Church, VA, 22042, USA.
Syed V; Department of Gynecologic Surgery and Obstetrics, Uniformed Services University, Room# A-3080, 4301 Jones Bridge Road, Bethesda, MD, 20814, USA. .; John P. Murtha Cancer Center, Walter Reed National Military Medical Center, 8901 Wisconsin Avenue, Bethesda, MD, 20889, USA. .; Department of Molecular and Cell Biology, Uniformed Services University, 4301 Jones Bridge Road, Bethesda, MD, 20814, USA. .
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Źródło :
Apoptosis : an international journal on programmed cell death [Apoptosis] 2021 Apr; Vol. 26 (3-4), pp. 184-194. Date of Electronic Publication: 2021 Jan 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Caspases*/drug effects
Caspases*/metabolism
Apoptosis/*drug effects
Endometrial Neoplasms/*metabolism
Ovarian Neoplasms/*metabolism
Progesterone/*pharmacology
Calcitriol/metabolism ; Caspase 8/drug effects ; Caspase 8/metabolism ; Caspase 9/drug effects ; Caspase 9/metabolism ; Cell Line, Tumor ; Cytochromes c/drug effects ; Cytochromes c/metabolism ; Death Domain Receptor Signaling Adaptor Proteins/drug effects ; Death Domain Receptor Signaling Adaptor Proteins/metabolism ; Death Domain Superfamily/drug effects ; Endometrial Neoplasms/drug therapy ; Fas Ligand Protein/drug effects ; Fas Ligand Protein/metabolism ; Female ; Humans ; In Vitro Techniques ; Membrane Potential, Mitochondrial/drug effects ; Ovarian Neoplasms/drug therapy ; Signal Transduction/drug effects ; fas Receptor/drug effects ; fas Receptor/metabolism
Czasopismo naukowe
Tytuł :
Maternal high-fat diet exaggerates diet-induced insulin resistance in adult offspring by enhancing inflammasome activation through noncanonical pathway of caspase-11.
Autorzy :
Wada N; Department of Cardiovascular Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Yamada H; Department of Cardiovascular Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan. Electronic address: .
Motoyama S; Department of Cardiovascular Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Saburi M; Department of Cardiovascular Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Sugimoto T; Department of Cardiovascular Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Kubota H; Department of Cardiovascular Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Miyawaki D; Department of Cardiovascular Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Wakana N; Department of Cardiovascular Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Kami D; Department of Regenerative Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Ogata T; Department of Pathology and Cell Regulation, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Matoba S; Department of Cardiovascular Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
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Źródło :
Molecular metabolism [Mol Metab] 2020 Jul; Vol. 37, pp. 100988. Date of Electronic Publication: 2020 Apr 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Caspases, Initiator/*metabolism
Inflammasomes/*metabolism
Insulin Resistance/*physiology
Animals ; Caspases/metabolism ; Caspases, Initiator/physiology ; Cytokines/metabolism ; Diet, High-Fat/adverse effects ; Female ; Inflammasomes/physiology ; Insulin/metabolism ; Macrophages/metabolism ; Male ; Maternal Exposure ; Mice ; Mice, Inbred C57BL ; Obesity ; Pregnancy ; Prenatal Exposure Delayed Effects/metabolism
Czasopismo naukowe
Tytuł :
Analysis of the lamprey genotype provides insights into caspase evolution and functional divergence.
Autorzy :
Liu Y; College of Life Sciences, Liaoning Normal University, Dalian, 116081, China; Lamprey Research Center, Liaoning Normal University, Dalian, 116081, China.
Xu X; College of Life Sciences, Liaoning Normal University, Dalian, 116081, China; Lamprey Research Center, Liaoning Normal University, Dalian, 116081, China.
Wang X; College of Life Sciences, Liaoning Normal University, Dalian, 116081, China; Lamprey Research Center, Liaoning Normal University, Dalian, 116081, China.
Zhu T; College of Life Sciences, Liaoning Normal University, Dalian, 116081, China; Lamprey Research Center, Liaoning Normal University, Dalian, 116081, China.
Li J; College of Life Sciences, Liaoning Normal University, Dalian, 116081, China; Lamprey Research Center, Liaoning Normal University, Dalian, 116081, China.
Pang Y; College of Life Sciences, Liaoning Normal University, Dalian, 116081, China; Lamprey Research Center, Liaoning Normal University, Dalian, 116081, China. Electronic address: .
Li Q; College of Life Sciences, Liaoning Normal University, Dalian, 116081, China; Lamprey Research Center, Liaoning Normal University, Dalian, 116081, China. Electronic address: .
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Źródło :
Molecular immunology [Mol Immunol] 2021 Apr; Vol. 132, pp. 8-20. Date of Electronic Publication: 2021 Jan 29.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Immunity, Innate*/genetics
Apoptosis/*genetics
Caspases/*genetics
Lampreys/*genetics
Signal Transduction/*immunology
Animals ; Apoptosis/drug effects ; Caspase 1/chemistry ; Caspase 1/genetics ; Caspase 1/isolation & purification ; Caspase 1/metabolism ; Caspase 3/chemistry ; Caspase 3/genetics ; Caspase 3/metabolism ; Caspase 6/chemistry ; Caspase 6/genetics ; Caspase 6/metabolism ; Caspase 7/chemistry ; Caspase 7/genetics ; Caspase 7/isolation & purification ; Caspase 7/metabolism ; Caspase 8/chemistry ; Caspase 8/genetics ; Caspase 8/metabolism ; Caspase 9/chemistry ; Caspase 9/genetics ; Caspase 9/metabolism ; Caspase Inhibitors/pharmacology ; Caspases/chemistry ; Caspases/isolation & purification ; Caspases/metabolism ; Evolution, Molecular ; Gene Duplication ; Gene Rearrangement ; Genome ; Genomics ; HeLa Cells ; Humans ; Lampreys/growth & development ; Lampreys/immunology ; Lampreys/metabolism ; Phylogeny ; Recombinant Proteins ; Sequence Alignment ; Signal Transduction/genetics ; Staphylococcus aureus/drug effects ; Up-Regulation ; Vibrio/drug effects
SCR Organism :
Vibrio anguillarum
Czasopismo naukowe
Tytuł :
Neutrophil Caspase-11 Is Essential to Defend against a Cytosol-Invasive Bacterium.
Autorzy :
Kovacs SB; Department of Immunology, Duke University, Durham, NC 27710, USA; Department of Molecular Genetics and Microbiology, Duke University, Durham, NC 27710, USA; Department of Microbiology and Immunology, Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Oh C; Department of Microbiology and Immunology, Center for Microbial Pathogenesis and Host Responses, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
Maltez VI; Department of Microbiology and Immunology, Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
McGlaughon BD; Department of Microbiology and Immunology, Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Verma A; Department of Microbiology and Immunology, Center for Microbial Pathogenesis and Host Responses, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
Miao EA; Department of Immunology, Duke University, Durham, NC 27710, USA; Department of Molecular Genetics and Microbiology, Duke University, Durham, NC 27710, USA; Department of Microbiology and Immunology, Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address: .
Aachoui Y; Department of Microbiology and Immunology, Center for Microbial Pathogenesis and Host Responses, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA. Electronic address: .
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Źródło :
Cell reports [Cell Rep] 2020 Jul 28; Vol. 32 (4), pp. 107967.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Caspases, Initiator/*metabolism
Neutrophils/*metabolism
Pyroptosis/*physiology
Animals ; Apoptosis Regulatory Proteins/metabolism ; Burkholderia/pathogenicity ; Calcium-Binding Proteins/metabolism ; Caspase 1/metabolism ; Caspases/metabolism ; Cytosol/metabolism ; Female ; Inflammasomes/metabolism ; Interleukin-18/metabolism ; Interleukin-1beta/metabolism ; Intracellular Signaling Peptides and Proteins/metabolism ; Macrophages/metabolism ; Macrophages/microbiology ; Male ; Mice ; Mice, Inbred C57BL ; Neutrophils/microbiology ; Phosphate-Binding Proteins/metabolism ; Pyroptosis/immunology
SCR Organism :
Burkholderia thailandensis
Czasopismo naukowe
Tytuł :
The insect peptide CopA3 blocks programmed cell death by directly binding caspases and inhibiting their proteolytic activation.
Autorzy :
Kim YH; Department of Life Science, College of Natural Science, Daejin University, Pocheon, Gyeonggido, 487-711, Republic of Korea.
Hwang JS; Department of Agricultural Biology, National Academy of Agricultural Science, RDA, Suwon, 441-707, Republic of Korea.
Yoon IN; Department of Life Science, College of Natural Science, Daejin University, Pocheon, Gyeonggido, 487-711, Republic of Korea.
Lee JH; Department of Agricultural Biology, National Academy of Agricultural Science, RDA, Suwon, 441-707, Republic of Korea.
Lee J; Department of Pathology, Daejeon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Daeheung-ro 64, Jung-gu, Daejeon, 301-723, Republic of Korea.
Park KC; Clinical Research Institute, Daejeon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Daejeon, Republic of Korea.
Seok H; Korea Brain Bank, Korea Brain Research Institute, Daegu, 41062, Republic of Korea.
Kim H; Department of Life Science, College of Natural Science, Daejin University, Pocheon, Gyeonggido, 487-711, Republic of Korea. Electronic address: .
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2021 Apr 02; Vol. 547, pp. 82-88. Date of Electronic Publication: 2021 Feb 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antimicrobial Cationic Peptides/*pharmacology
Caspases/*metabolism
Insect Proteins/*pharmacology
Neoplasms/*drug therapy
Amino Acid Sequence ; Apoptosis/drug effects ; Caspases/chemistry ; Cell Line, Tumor ; Humans ; Neoplasms/metabolism ; Neoplasms/pathology ; Proteolysis ; Surface Plasmon Resonance/methods
Czasopismo naukowe

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