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Tytuł :
[Advances in the metabolic engineering for the production of tetracarbon organic acids].
Autorzy :
Wang Y; State Key Laboratory of Materials-Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing 211816, Jiangsu, China.
Guo F; State Key Laboratory of Materials-Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing 211816, Jiangsu, China.
Yan W; State Key Laboratory of Materials-Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing 211816, Jiangsu, China.
Xin F; State Key Laboratory of Materials-Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing 211816, Jiangsu, China.; Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing Tech University, Nanjing 211816, Jiangsu, China.
Zhang W; State Key Laboratory of Materials-Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing 211816, Jiangsu, China.; Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing Tech University, Nanjing 211816, Jiangsu, China.
Jiang M; State Key Laboratory of Materials-Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing 211816, Jiangsu, China.; Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing Tech University, Nanjing 211816, Jiangsu, China.
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Źródło :
Sheng wu gong cheng xue bao = Chinese journal of biotechnology [Sheng Wu Gong Cheng Xue Bao] 2021 May 25; Vol. 37 (5), pp. 1697-1720.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Metabolic Engineering*
Organic Chemicals*
Acids ; Biosynthetic Pathways ; Fermentation
Czasopismo naukowe
Tytuł :
Potential applications of halophilic microorganisms for biological treatment of industrial process brines contaminated with aromatics.
Autorzy :
Mainka T; Institute for Chemical, Environmental and Bioscience Engineering, TU Wien, Gumpendorfer Straße 1a, 1060 Vienna, Austria.; Competence Center CHASE GmbH, Altenbergerstraße 69, 4040 Linz, Austria.
Weirathmüller D; Institute for Chemical, Environmental and Bioscience Engineering, TU Wien, Gumpendorfer Straße 1a, 1060 Vienna, Austria.
Herwig C; Institute for Chemical, Environmental and Bioscience Engineering, TU Wien, Gumpendorfer Straße 1a, 1060 Vienna, Austria.; Competence Center CHASE GmbH, Altenbergerstraße 69, 4040 Linz, Austria.
Pflügl S; Institute for Chemical, Environmental and Bioscience Engineering, TU Wien, Gumpendorfer Straße 1a, 1060 Vienna, Austria.
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Źródło :
Journal of industrial microbiology & biotechnology [J Ind Microbiol Biotechnol] 2021 Apr 30; Vol. 48 (1-2).
Typ publikacji :
Journal Article
MeSH Terms :
Organic Chemicals/*metabolism
Waste Water/*chemistry
Biodegradation, Environmental ; Organic Chemicals/chemistry ; Water Purification
Czasopismo naukowe
Tytuł :
Decrypting bacterial polyphenol metabolism in an anoxic wetland soil.
Autorzy :
McGivern BB; Colorado State University, Fort Collins, CO, USA.
Tfaily MM; University of Arizona, Tucson, AZ, USA.
Borton MA; Colorado State University, Fort Collins, CO, USA.
Kosina SM; Environmental Genomics and Systems Biology, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.
Daly RA; Colorado State University, Fort Collins, CO, USA.
Nicora CD; Pacific Northwest National Laboratory, Richland, WA, USA.
Purvine SO; Pacific Northwest National Laboratory, Richland, WA, USA.
Wong AR; Pacific Northwest National Laboratory, Richland, WA, USA.
Lipton MS; Environmental Genomics and Systems Biology, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.
Hoyt DW; Pacific Northwest National Laboratory, Richland, WA, USA.
Northen TR; University of Arizona, Tucson, AZ, USA.
Hagerman AE; Miami University, Oxford, OH, USA.
Wrighton KC; Colorado State University, Fort Collins, CO, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Apr 29; Vol. 12 (1), pp. 2466. Date of Electronic Publication: 2021 Apr 29.
Typ publikacji :
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Biodegradation, Environmental*
Bacteria/*metabolism
Organic Chemicals/*metabolism
Polyphenols/*metabolism
Soil Pollutants/*metabolism
Anaerobiosis ; Bioreactors/microbiology ; Microbiota/physiology ; Organic Chemicals/chemistry ; Soil/chemistry ; Soil Microbiology ; Wetlands
Czasopismo naukowe
Tytuł :
Automated liquid-liquid extraction of organic compounds from aqueous samples using a multifunction autosampler syringe.
Autorzy :
Tehranirokh M; ARC Training Centre for Portable Analytical Separation Technologies (ASTech), University of Tasmania, Private Bag 75 Hobart, 7001 Australia; Trajan Scientific and Medical, 7 Argent Place Ringwood, 3134 Australia.
Van den Bronk M; Trajan Scientific and Medical, 7 Argent Place Ringwood, 3134 Australia.
Smith P; Trajan Scientific and Medical, 7 Argent Place Ringwood, 3134 Australia.
Dai Z; Trajan Scientific and Medical, 7 Argent Place Ringwood, 3134 Australia.
Ragunathan K; Trajan Scientific and Medical, 7 Argent Place Ringwood, 3134 Australia.
Muscalu A; Ministry of the Environment, Conservation and Parks, 125 Resources Rd, Toronto, ON, Canada.
Mills S; Envirolab Services Sydney, 12 Ashley Street Chatswood, 2067 Australia.
Breadmore MC; ARC Training Centre for Portable Analytical Separation Technologies (ASTech), University of Tasmania, Private Bag 75 Hobart, 7001 Australia; Australian Centre for Research on Separation Science (ACROSS), University of Tasmania, Private Bag 75 Hobart, 7001 Australia.
Shellie RA; ARC Training Centre for Portable Analytical Separation Technologies (ASTech), University of Tasmania, Private Bag 75 Hobart, 7001 Australia; Trajan Scientific and Medical, 7 Argent Place Ringwood, 3134 Australia; CASS Food Research Centre, School of Exercise and Nutrition Sciences, Deakin University, 221 Burwood Highway Burwood, 3125 Australia. Electronic address: .
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Źródło :
Journal of chromatography. A [J Chromatogr A] 2021 Apr 12; Vol. 1642, pp. 462032. Date of Electronic Publication: 2021 Mar 03.
Typ publikacji :
Journal Article
MeSH Terms :
Liquid-Liquid Extraction/*instrumentation
Liquid-Liquid Extraction/*methods
Organic Chemicals/*isolation & purification
Water/*chemistry
Gas Chromatography-Mass Spectrometry ; Organic Chemicals/analysis ; Polychlorinated Biphenyls/analysis ; Polychlorinated Biphenyls/isolation & purification ; Polycyclic Aromatic Hydrocarbons/analysis ; Polycyclic Aromatic Hydrocarbons/isolation & purification ; Solvents ; Syringes ; Water Pollutants, Chemical/analysis
Czasopismo naukowe
Tytuł :
Targeting Lysosomal Degradation Pathways: New Strategies and Techniques for Drug Discovery.
Autorzy :
Pei J; State Key Laboratory of Biotherapy and Cancer Center, National Clinical Research Center for Geriatrics, Innovation Center of Nursing Research, Nursing Key Laboratory of Sichuan Province, West China Hospital, and Collaborative Innovation Center of Biotherapy, Sichuan University, Chengdu 610041, China.
Wang G; State Key Laboratory of Biotherapy and Cancer Center, National Clinical Research Center for Geriatrics, Innovation Center of Nursing Research, Nursing Key Laboratory of Sichuan Province, West China Hospital, and Collaborative Innovation Center of Biotherapy, Sichuan University, Chengdu 610041, China.
Feng L; State Key Laboratory of Biotherapy and Cancer Center, National Clinical Research Center for Geriatrics, Innovation Center of Nursing Research, Nursing Key Laboratory of Sichuan Province, West China Hospital, and Collaborative Innovation Center of Biotherapy, Sichuan University, Chengdu 610041, China.
Zhang J; State Key Laboratory of Biotherapy and Cancer Center, National Clinical Research Center for Geriatrics, Innovation Center of Nursing Research, Nursing Key Laboratory of Sichuan Province, West China Hospital, and Collaborative Innovation Center of Biotherapy, Sichuan University, Chengdu 610041, China.
Jiang T; State Key Laboratory of Biotherapy and Cancer Center, National Clinical Research Center for Geriatrics, Innovation Center of Nursing Research, Nursing Key Laboratory of Sichuan Province, West China Hospital, and Collaborative Innovation Center of Biotherapy, Sichuan University, Chengdu 610041, China.
Sun Q; State Key Laboratory of Biotherapy and Cancer Center, National Clinical Research Center for Geriatrics, Innovation Center of Nursing Research, Nursing Key Laboratory of Sichuan Province, West China Hospital, and Collaborative Innovation Center of Biotherapy, Sichuan University, Chengdu 610041, China.
Ouyang L; State Key Laboratory of Biotherapy and Cancer Center, National Clinical Research Center for Geriatrics, Innovation Center of Nursing Research, Nursing Key Laboratory of Sichuan Province, West China Hospital, and Collaborative Innovation Center of Biotherapy, Sichuan University, Chengdu 610041, China.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2021 Apr 08; Vol. 64 (7), pp. 3493-3507. Date of Electronic Publication: 2021 Mar 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Lysosomes/*metabolism
Organic Chemicals/*pharmacology
Peptides/*pharmacology
Proteins/*metabolism
Amino Acid Sequence ; Animals ; Autophagosomes/metabolism ; Autophagy/physiology ; Drug Discovery ; Endocytosis/physiology ; Humans ; Organic Chemicals/metabolism ; Peptides/metabolism ; Protein Binding ; Proteolysis
Czasopismo naukowe
Tytuł :
The use of dried blood spots for characterizing children's exposure to organic environmental chemicals.
Autorzy :
Barr DB; Emory University, Rollins School of Public Health, Gangarosa Department of Environmental Health, Atlanta, GA, USA. Electronic address: .
Kannan K; Department of Pediatrics and Department of Environmental Medicine, New York University School of Medicine, New York, NY, USA.
Cui Y; National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.
Merrill L; Westat, Rockville, MD, USA.
Petrick LM; The Senator Frank R. Lautenberg Environmental Health Sciences Laboratory, Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Meeker JD; School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Fennell TR; RTI International, Research Triangle Park, NC, USA.
Faustman EM; University of Washington, School of Public Health, Department of Environmental and Occupational Health, Seattle, WA, USA.
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Źródło :
Environmental research [Environ Res] 2021 Apr; Vol. 195, pp. 110796. Date of Electronic Publication: 2021 Jan 25.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Review
MeSH Terms :
Biological Monitoring*
Organic Chemicals*
Child ; Dried Blood Spot Testing ; Environmental Exposure/analysis ; Humans ; Infant, Newborn ; Reproducibility of Results ; Retrospective Studies
Czasopismo naukowe
Tytuł :
Targeting Bromodomain and Extraterminal Proteins for Drug Discovery: From Current Progress to Technological Development.
Autorzy :
Tang P; State Key Laboratory of Biotherapy and Cancer Center, National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu 610041, China.
Zhang J; State Key Laboratory of Biotherapy and Cancer Center, National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu 610041, China.
Liu J; State Key Laboratory of Biotherapy and Cancer Center, National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu 610041, China.
Chiang CM; Simmons Comprehensive Cancer Center, Department of Pharmacology, and Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390, United States.
Ouyang L; State Key Laboratory of Biotherapy and Cancer Center, National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu 610041, China.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2021 Mar 11; Vol. 64 (5), pp. 2419-2435. Date of Electronic Publication: 2021 Feb 22.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Organic Chemicals/*therapeutic use
Transcription Factors/*antagonists & inhibitors
Amino Acid Sequence ; Animals ; Cell Line, Tumor ; Clinical Trials as Topic ; Drug Discovery ; Humans ; Organic Chemicals/metabolism ; Organic Chemicals/pharmacology ; Protein Binding/drug effects ; Protein Domains ; Protein Multimerization/drug effects ; Proteolysis/drug effects ; Transcription Factors/chemistry ; Transcription Factors/metabolism
Czasopismo naukowe
Tytuł :
Reversible Lysine Specific Demethylase 1 (LSD1) Inhibitors: A Promising Wrench to Impair LSD1.
Autorzy :
Dai XJ; Key Lab of Advanced Drug Preparation Technologies, Ministry of Education of China, State Key Laboratory of Esophageal Cancer Prevention & Treatment, Key Laboratory of Henan Province for Drug Quality and Evaluation, Institute of Drug Discovery and Development, School of Pharmaceutical Sciences, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, Henan 450001, China.
Liu Y; Key Lab of Advanced Drug Preparation Technologies, Ministry of Education of China, State Key Laboratory of Esophageal Cancer Prevention & Treatment, Key Laboratory of Henan Province for Drug Quality and Evaluation, Institute of Drug Discovery and Development, School of Pharmaceutical Sciences, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, Henan 450001, China.
Xue LP; Key Lab of Advanced Drug Preparation Technologies, Ministry of Education of China, State Key Laboratory of Esophageal Cancer Prevention & Treatment, Key Laboratory of Henan Province for Drug Quality and Evaluation, Institute of Drug Discovery and Development, School of Pharmaceutical Sciences, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, Henan 450001, China.
Xiong XP; Key Lab of Advanced Drug Preparation Technologies, Ministry of Education of China, State Key Laboratory of Esophageal Cancer Prevention & Treatment, Key Laboratory of Henan Province for Drug Quality and Evaluation, Institute of Drug Discovery and Development, School of Pharmaceutical Sciences, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, Henan 450001, China.
Zhou Y; Key Lab of Advanced Drug Preparation Technologies, Ministry of Education of China, State Key Laboratory of Esophageal Cancer Prevention & Treatment, Key Laboratory of Henan Province for Drug Quality and Evaluation, Institute of Drug Discovery and Development, School of Pharmaceutical Sciences, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, Henan 450001, China.
Zheng YC; Key Lab of Advanced Drug Preparation Technologies, Ministry of Education of China, State Key Laboratory of Esophageal Cancer Prevention & Treatment, Key Laboratory of Henan Province for Drug Quality and Evaluation, Institute of Drug Discovery and Development, School of Pharmaceutical Sciences, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, Henan 450001, China.
Liu HM; Key Lab of Advanced Drug Preparation Technologies, Ministry of Education of China, State Key Laboratory of Esophageal Cancer Prevention & Treatment, Key Laboratory of Henan Province for Drug Quality and Evaluation, Institute of Drug Discovery and Development, School of Pharmaceutical Sciences, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, Henan 450001, China.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2021 Mar 11; Vol. 64 (5), pp. 2466-2488. Date of Electronic Publication: 2021 Feb 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Enzyme Inhibitors/*therapeutic use
Histone Demethylases/*antagonists & inhibitors
Organic Chemicals/*therapeutic use
Animals ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Cell Line, Tumor ; Enzyme Inhibitors/chemistry ; Enzyme Inhibitors/pharmacology ; Humans ; Molecular Structure ; Neoplasms/drug therapy ; Organic Chemicals/chemistry ; Organic Chemicals/pharmacology ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Tolerability, safety, pharmacokinetics and pharmacodynamics of SHR0534, a potent G protein-coupled receptor 40 (GPR40) agonist, at single- and multiple-ascending oral doses in healthy Chinese subjects.
Autorzy :
Zhao Y; Phase I Clinical Trial Unit, Jiangsu Province Hospital and the First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
Xie L; Phase I Clinical Trial Unit, Jiangsu Province Hospital and the First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
Ou N; Phase I Clinical Trial Unit, Jiangsu Province Hospital and the First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
Wu J; Jiangsu Hengrui Medicine Co., Ltd., Lianyungang, China.
Zhang H; Phase I Clinical Trial Unit, Jiangsu Province Hospital and the First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
Zhou S; Phase I Clinical Trial Unit, Jiangsu Province Hospital and the First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
Liu Y; Phase I Clinical Trial Unit, Jiangsu Province Hospital and the First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
Chen J; Phase I Clinical Trial Unit, Jiangsu Province Hospital and the First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
Wang L; Phase I Clinical Trial Unit, Jiangsu Province Hospital and the First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
Wang L; Phase I Clinical Trial Unit, Jiangsu Province Hospital and the First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
Wang J; Jiangsu Hengrui Medicine Co., Ltd., Lianyungang, China.
Shao F; Phase I Clinical Trial Unit, Jiangsu Province Hospital and the First Affiliated Hospital with Nanjing Medical University, Nanjing, China.; Pharmacy College, Nanjing Medical University, Nanjing, China.
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Źródło :
Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2021 Mar; Vol. 51 (3), pp. 297-306. Date of Electronic Publication: 2020 Dec 28.
Typ publikacji :
Journal Article; Randomized Controlled Trial
MeSH Terms :
Hypoglycemic Agents/*pharmacokinetics
Organic Chemicals/*pharmacokinetics
Receptors, G-Protein-Coupled/*agonists
Administration, Oral ; Adult ; Area Under Curve ; China ; Diabetes Mellitus, Type 2 ; Dose-Response Relationship, Drug ; Double-Blind Method ; Healthy Volunteers ; Humans ; Hypoglycemic Agents/administration & dosage ; Hypoglycemic Agents/pharmacology ; Metabolic Clearance Rate ; Organic Chemicals/administration & dosage ; Organic Chemicals/pharmacology
Czasopismo naukowe
Tytuł :
Environmental Sorption Behavior of Ionic and Ionizable Organic Chemicals.
Autorzy :
Henneberger L; Helmholtz Centre for Environmental Research UFZ, Leipzig, Germany.
Goss KU; Helmholtz Centre for Environmental Research UFZ, Leipzig, Germany. .; Institute of Chemistry, University of Halle-Wittenberg, Halle, Germany. .
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Źródło :
Reviews of environmental contamination and toxicology [Rev Environ Contam Toxicol] 2021; Vol. 253, pp. 43-64.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Adsorption*
Organic Chemicals*
Soil*
Bioaccumulation ; Cations
Czasopismo naukowe
Tytuł :
Mobility of organic compounds in a soft clay-rich rock (Tégulines clay, France).
Autorzy :
Guo N; Université Paris-Saclay, CEA, Service d'Étude du Comportement des Radionucléides, 91191, Gif-sur-Yvette, France.
Disdier Z; Université Paris-Saclay, CEA, Service d'Étude du Comportement des Radionucléides, 91191, Gif-sur-Yvette, France.
Thory É; Université Paris-Saclay, CEA, Service d'Étude du Comportement des Radionucléides, 91191, Gif-sur-Yvette, France.
Robinet JC; Andra, R&D Division, Parc de la Croix Blanche, 92298, Châtenay-Malabry, France.
Dagnelie RVH; Université Paris-Saclay, CEA, Service d'Étude du Comportement des Radionucléides, 91191, Gif-sur-Yvette, France. Electronic address: .
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Źródło :
Chemosphere [Chemosphere] 2021 Jul; Vol. 275, pp. 130048. Date of Electronic Publication: 2021 Feb 22.
Typ publikacji :
Journal Article
MeSH Terms :
Aluminum Silicates*
Organic Chemicals*
Adsorption ; Clay ; France ; Soil
Czasopismo naukowe
Tytuł :
Subcritical water extraction of organic acids from chicken manure.
Autorzy :
Sushkova S; Southern Federal University, Bolshaya Sadovaya 105, Rostov-on-Don, 344006, Russian Federation.
Minkina T; Southern Federal University, Bolshaya Sadovaya 105, Rostov-on-Don, 344006, Russian Federation.
Chaplygin V; Southern Federal University, Bolshaya Sadovaya 105, Rostov-on-Don, 344006, Russian Federation.
Nevidomskaya D; Southern Federal University, Bolshaya Sadovaya 105, Rostov-on-Don, 344006, Russian Federation.
Rajput V; Southern Federal University, Bolshaya Sadovaya 105, Rostov-on-Don, 344006, Russian Federation.
Bauer T; Southern Federal University, Bolshaya Sadovaya 105, Rostov-on-Don, 344006, Russian Federation.
Mazarji M; Southern Federal University, Bolshaya Sadovaya 105, Rostov-on-Don, 344006, Russian Federation.
Bren AB; Southern Federal University, Bolshaya Sadovaya 105, Rostov-on-Don, 344006, Russian Federation.; Don State Technical University, Gagarina Square 1, Rostov-on-Don, 344002, Russian Federation.
Popov I; Don State Technical University, Gagarina Square 1, Rostov-on-Don, 344002, Russian Federation.
Mazanko M; Southern Federal University, Bolshaya Sadovaya 105, Rostov-on-Don, 344006, Russian Federation.; Don State Technical University, Gagarina Square 1, Rostov-on-Don, 344002, Russian Federation.
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Źródło :
Journal of the science of food and agriculture [J Sci Food Agric] 2021 Mar 15; Vol. 101 (4), pp. 1523-1529. Date of Electronic Publication: 2020 Sep 19.
Typ publikacji :
Journal Article
MeSH Terms :
Manure/*analysis
Organic Chemicals/*isolation & purification
Water/*chemistry
Animals ; Carbon/analysis ; Chickens ; Humic Substances/analysis ; Organic Chemicals/chemistry ; Temperature
Czasopismo naukowe
Tytuł :
Quantitative structure activity relationships (QSARs) and machine learning models for abiotic reduction of organic compounds by an aqueous Fe(II) complex.
Autorzy :
Gao Y; Department of Civil and Environmental Engineering, Case Western Reserve University, Cleveland, OH 44106, United States.
Zhong S; Department of Civil and Environmental Engineering, Case Western Reserve University, Cleveland, OH 44106, United States.
Torralba-Sanchez TL; OHSU-PSU School of Public Health, Oregon Health & Science University, 181 SW Sam Jackson Park Road, Portland, OR 97239, United States.
Tratnyek PG; OHSU-PSU School of Public Health, Oregon Health & Science University, 181 SW Sam Jackson Park Road, Portland, OR 97239, United States.
Weber EJ; Center for Environmental Modeling and Measurement, U.S. Environmental Protection Agency, 960 College Station Road, Athens, GA 30605, United States.
Chen Y; Department of Civil, Environmental, and Geo- Engineering, University of Minnesota, 500 Pillsbury Drive SE, Minneapolis, MN 55455-0116, United States.
Zhang H; Department of Civil and Environmental Engineering, Case Western Reserve University, Cleveland, OH 44106, United States. Electronic address: .
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Źródło :
Water research [Water Res] 2021 Mar 15; Vol. 192, pp. 116843. Date of Electronic Publication: 2021 Jan 15.
Typ publikacji :
Journal Article
MeSH Terms :
Organic Chemicals*
Quantitative Structure-Activity Relationship*
Ferrous Compounds ; Humans ; Machine Learning ; Water
Czasopismo naukowe
Tytuł :
A Decade of FDA-Approved Drugs (2010-2019): Trends and Future Directions.
Autorzy :
Brown DG; Jnana Therapeutics, 6 Tide St., Boston, Massachusetts 02210, United States.
Wobst HJ; Jnana Therapeutics, 6 Tide St., Boston, Massachusetts 02210, United States.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2021 Mar 11; Vol. 64 (5), pp. 2312-2338. Date of Electronic Publication: 2021 Feb 22.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Drug Approval*
Organic Chemicals/*therapeutic use
United States Food and Drug Administration/*trends
Biosimilar Pharmaceuticals/chemistry ; Biosimilar Pharmaceuticals/therapeutic use ; Clinical Trials as Topic ; Humans ; Organic Chemicals/chemistry ; United States
Czasopismo naukowe
Tytuł :
U.S. FDA Approved Drugs from 2015-June 2020: A Perspective.
Autorzy :
Bhutani P; Pharmaceutical Candidate Optimization, Biocon Bristol-Myers Squibb R&D Centre, Syngene International Limited, Bangalore 560099, India.; Department of Pharmacy, Birla Institute of Technology and Science (BITS) Pilani, Pilani Campus, Rajasthan 333031, India.
Joshi G; Laboratory for Drug Design and Synthesis, Department of Pharmaceutical Sciences and Natural Products, Central University of Punjab, Bathinda 151001, India.
Raja N; Pharmaceutical Candidate Optimization, Biocon Bristol-Myers Squibb R&D Centre, Syngene International Limited, Bangalore 560099, India.
Bachhav N; 1015 E Cozza Drive # 12, Spokane Washington 99208, United States.
Rajanna PK; Pharmaceutical Candidate Optimization, Biocon Bristol-Myers Squibb R&D Centre, Syngene International Limited, Bangalore 560099, India.
Bhutani H; Pharmaceutical Development, Biocon Bristol-Myers Squibb R&D Centre, Bristol-Myers Squibb India Private Limited, Bangalore 560099, India.
Paul AT; Department of Pharmacy, Birla Institute of Technology and Science (BITS) Pilani, Pilani Campus, Rajasthan 333031, India.
Kumar R; Laboratory for Drug Design and Synthesis, Department of Pharmaceutical Sciences and Natural Products, Central University of Punjab, Bathinda 151001, India.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2021 Mar 11; Vol. 64 (5), pp. 2339-2381. Date of Electronic Publication: 2021 Feb 22.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Drug Approval*
Organic Chemicals/*therapeutic use
Humans ; Organic Chemicals/chemistry ; United States ; United States Food and Drug Administration
Czasopismo naukowe
Tytuł :
Identification of Novel High-Affinity Substrates of OCT1 Using Machine Learning-Guided Virtual Screening and Experimental Validation.
Autorzy :
Jensen O; Institute of Clinical Pharmacology, University Medical Center Göttingen, D-37075 Göttingen, Germany.
Brockmöller J; Institute of Clinical Pharmacology, University Medical Center Göttingen, D-37075 Göttingen, Germany.
Dücker C; Institute of Clinical Pharmacology, University Medical Center Göttingen, D-37075 Göttingen, Germany.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2021 Mar 11; Vol. 64 (5), pp. 2762-2776. Date of Electronic Publication: 2021 Feb 19.
Typ publikacji :
Journal Article
MeSH Terms :
Octamer Transcription Factor-1/*metabolism
Organic Chemicals/*metabolism
Databases, Chemical ; Drug Evaluation, Preclinical ; HEK293 Cells ; Humans ; Machine Learning ; Organic Chemicals/chemistry
Czasopismo naukowe
Tytuł :
Efficacy and safety of the novel glycine transporter inhibitor BI 425809 once daily in patients with schizophrenia: a double-blind, randomised, placebo-controlled phase 2 study.
Autorzy :
Fleischhacker WW; Medical University Innsbruck, Innsbruck, Austria.
Podhorna J; Boehringer Ingelheim International GmbH, Ingelheim am Rhein, Germany. Electronic address: .
Gröschl M; Boehringer Ingelheim, Vienna, Austria.
Hake S; Boehringer Ingelheim, Vienna, Austria.
Zhao Y; Boehringer Ingelheim Pharmaceuticals, Ridgefield, CT, USA.
Huang S; Boehringer Ingelheim Pharmaceuticals, Ridgefield, CT, USA.
Keefe RSE; Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA; VeraSci, Durham, NC, USA.
Desch M; Boehringer Ingelheim Pharma, Biberach an der Riss, Germany.
Brenner R; Neurobehavioral Research, Cedarhurst, NY, USA.
Walling DP; CNS Network, Garden Grove, CA, USA.
Mantero-Atienza E; Premier Clinical Research Institute, Miami, FL, USA.
Nakagome K; National Center of Neurology and Psychiatry, Tokyo, Japan.
Pollentier S; Boehringer Ingelheim International GmbH, Ingelheim am Rhein, Germany.
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Źródło :
The lancet. Psychiatry [Lancet Psychiatry] 2021 Mar; Vol. 8 (3), pp. 191-201.
Typ publikacji :
Clinical Trial, Phase II; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms :
Cognition/*drug effects
Glycine Plasma Membrane Transport Proteins/*antagonists & inhibitors
Organic Chemicals/*administration & dosage
Schizophrenia/*drug therapy
Adolescent ; Adult ; Cognitive Dysfunction/drug therapy ; Dose-Response Relationship, Drug ; Double-Blind Method ; Female ; Humans ; Likelihood Functions ; Male ; Middle Aged ; Organic Chemicals/adverse effects ; Treatment Outcome ; Young Adult
Czasopismo naukowe

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