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Tytuł :
Dynamic regulation of B cell complement signaling is integral to germinal center responses.
Autorzy :
Cumpelik A; Renal Division, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Translational Transplant Research Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Heja D; Renal Division, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Translational Transplant Research Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; eGenesis Inc., Cambridge, MA, USA.
Hu Y; Renal Division, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Translational Transplant Research Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Varano G; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Translational Medicine, Laboratory for Advanced Therapy Technologies, University of Ferrara, Ferrara, Italy.
Ordikhani F; Renal Division, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Translational Transplant Research Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Roberto MP; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
He Z; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Homann D; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Lira SA; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Dominguez-Sola D; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. .; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. .; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. .; Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. .
Heeger PS; Renal Division, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA. .; Translational Transplant Research Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA. .; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. .
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Źródło :
Nature immunology [Nat Immunol] 2021 Jun; Vol. 22 (6), pp. 757-768. Date of Electronic Publication: 2021 May 24.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Complement Activation*
B-Lymphocytes/*immunology
Complement C3a/*metabolism
Complement C5a/*metabolism
Germinal Center/*immunology
Animals ; Animals, Genetically Modified ; B-Lymphocytes/metabolism ; CD55 Antigens/genetics ; CD55 Antigens/metabolism ; CD59 Antigens/metabolism ; Cell Line, Tumor ; Clonal Hematopoiesis/immunology ; Germinal Center/cytology ; Germinal Center/metabolism ; Humans ; Lymphocyte Activation ; Mice ; Palatine Tonsil/cytology ; Palatine Tonsil/pathology ; Proto-Oncogene Proteins c-bcl-6/metabolism ; Receptor, Anaphylatoxin C5a/genetics ; Receptor, Anaphylatoxin C5a/metabolism ; Receptors, Antigen, B-Cell/metabolism ; Receptors, Complement/genetics ; Receptors, Complement/metabolism ; Signal Transduction/immunology ; TOR Serine-Threonine Kinases/metabolism
Czasopismo naukowe
Tytuł :
Functional Hemolytic Test for Complement Alternative Pathway Convertase Activity.
Autorzy :
Michels MAHM; Department of Pediatric Nephrology, Radboud Institute for Molecular Life Sciences, Amalia Children's Hospital, Radboud University Medical Center, Nijmegen, The Netherlands.
van de Kar NCAJ; Department of Pediatric Nephrology, Radboud Institute for Molecular Life Sciences, Amalia Children's Hospital, Radboud University Medical Center, Nijmegen, The Netherlands.
Volokhina EB; Department of Pediatric Nephrology, Radboud Institute for Molecular Life Sciences, Amalia Children's Hospital, Radboud University Medical Center, Nijmegen, The Netherlands.; Department of Laboratory Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.
van den Heuvel BLPWJ; Department of Pediatric Nephrology, Radboud Institute for Molecular Life Sciences, Amalia Children's Hospital, Radboud University Medical Center, Nijmegen, The Netherlands. .; Department of Laboratory Medicine, Radboud University Medical Center, Nijmegen, The Netherlands. .; Department of Pediatrics/Pediatric Nephrology, University Hospitals Leuven, Leuven, Belgium. .; Department of Development and Regeneration, University Hospitals Leuven, Leuven, Belgium. .
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Źródło :
Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2021; Vol. 2227, pp. 83-96.
Typ publikacji :
Journal Article
MeSH Terms :
Complement Pathway, Alternative*/immunology
Complement C3-C5 Convertases/*metabolism
Complement Hemolytic Activity Assay/*methods
Animals ; Atypical Hemolytic Uremic Syndrome/blood ; Atypical Hemolytic Uremic Syndrome/diagnosis ; Atypical Hemolytic Uremic Syndrome/immunology ; Complement Activation ; Complement C3/immunology ; Complement C3 Nephritic Factor/analysis ; Complement C3 Nephritic Factor/immunology ; Complement C3-C5 Convertases/analysis ; Glomerulonephritis/blood ; Glomerulonephritis/diagnosis ; Glomerulonephritis/immunology ; Guinea Pigs ; Humans ; Rabbits
Czasopismo naukowe
Tytuł :
Amnion epithelial cells are an effective source of factor H and prevent kidney complement deposition in factor H-deficient mice.
Autorzy :
Casiraghi F; Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Via GB Camozzi 3, 24020, Ranica, Bergamo, Italy. .
Ordonez PYR; Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Via GB Camozzi 3, 24020, Ranica, Bergamo, Italy.
Azzollini N; Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Via GB Camozzi 3, 24020, Ranica, Bergamo, Italy.
Todeschini M; Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Via GB Camozzi 3, 24020, Ranica, Bergamo, Italy.
Rottoli D; Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Via GB Camozzi 3, 24020, Ranica, Bergamo, Italy.
Donadelli R; Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Via GB Camozzi 3, 24020, Ranica, Bergamo, Italy.
Gramignoli R; Department of Laboratory Medicine, Division of Pathology, Karolinska Institutet, Stockholm, Sweden.
Benigni A; Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Via GB Camozzi 3, 24020, Ranica, Bergamo, Italy.
Noris M; Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Via GB Camozzi 3, 24020, Ranica, Bergamo, Italy.
Remuzzi G; Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Via GB Camozzi 3, 24020, Ranica, Bergamo, Italy.
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Źródło :
Stem cell research & therapy [Stem Cell Res Ther] 2021 Jun 10; Vol. 12 (1), pp. 332. Date of Electronic Publication: 2021 Jun 10.
Typ publikacji :
Journal Article
MeSH Terms :
Amnion*
Complement Factor H*/genetics
Animals ; Complement C3/genetics ; Epithelial Cells ; Humans ; Kidney ; Mice
Czasopismo naukowe
Tytuł :
C5aR inhibition of nonimmune cells suppresses inflammation and maintains epithelial integrity in SARS-CoV-2-infected primary human airway epithelia.
Autorzy :
Posch W; Institute of Hygiene and Medical Microbiology, Medical University of Innsbruck, Innsbruck, Austria. Electronic address: .
Vosper J; Institute of Medical Biochemistry, Medical University of Innsbruck, Innsbruck, Austria.
Noureen A; Institute of Hygiene and Medical Microbiology, Medical University of Innsbruck, Innsbruck, Austria.
Zaderer V; Institute of Hygiene and Medical Microbiology, Medical University of Innsbruck, Innsbruck, Austria.
Witting C; Institute of Hygiene and Medical Microbiology, Medical University of Innsbruck, Innsbruck, Austria.
Bertacchi G; Institute of Hygiene and Medical Microbiology, Medical University of Innsbruck, Innsbruck, Austria.
Gstir R; ADSI - Austrian Drug Screening Institute GmbH, Innsbruck, Austria.
Filipek PA; ADSI - Austrian Drug Screening Institute GmbH, Innsbruck, Austria.
Bonn GK; ADSI - Austrian Drug Screening Institute GmbH, Innsbruck, Austria.
Huber LA; ADSI - Austrian Drug Screening Institute GmbH, Innsbruck, Austria; Institute of Cell Biology, Biocenter Innsbruck, Medical University of Innsbruck, Innsbruck, Austria.
Bellmann-Weiler R; University Hospital of Internal Medicine II, Medical University of Innsbruck, Innsbruck, Austria.
Lass-Flörl C; Institute of Hygiene and Medical Microbiology, Medical University of Innsbruck, Innsbruck, Austria.
Wilflingseder D; Institute of Hygiene and Medical Microbiology, Medical University of Innsbruck, Innsbruck, Austria. Electronic address: .
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Źródło :
The Journal of allergy and clinical immunology [J Allergy Clin Immunol] 2021 Jun; Vol. 147 (6), pp. 2083-2097.e6. Date of Electronic Publication: 2021 Apr 20.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Complement Activation*
Bronchi/*immunology
COVID-19/*immunology
Epithelial Cells/*immunology
Receptor, Anaphylatoxin C5a/*immunology
Respiratory Mucosa/*immunology
SARS-CoV-2/*immunology
Bronchi/pathology ; Bronchi/virology ; COVID-19/pathology ; COVID-19/virology ; Cell Line ; Complement C3/immunology ; Cytokines/immunology ; Epithelial Cells/pathology ; Epithelial Cells/virology ; Humans ; Inflammation/immunology ; Inflammation/pathology ; Respiratory Mucosa/pathology ; Respiratory Mucosa/virology
Czasopismo naukowe
Tytuł :
Changes in complement alternative pathway components, factor B and factor H during dengue virus infection in the AG129 mouse.
Autorzy :
Cabezas-Falcon S; Microbiology and Infectious Diseases, Flinders University, Bedford Park, Adelaide 5042, South Australia.
Norbury AJ; Microbiology and Infectious Diseases, Flinders University, Bedford Park, Adelaide 5042, South Australia.
Hulme-Jones J; Microbiology and Infectious Diseases, Flinders University, Bedford Park, Adelaide 5042, South Australia.
Klebe S; SA Pathology, Adelaide 5000, South Australia.; Anatomy and Pathology, College of Medicine and Public Health, Flinders University, Bedford Park, Adelaide 5042, South Australia.
Adamson P; Microbiology and Infectious Diseases, Flinders University, Bedford Park, Adelaide 5042, South Australia.
Rudd PA; Institute for Glycomics, Griffith University, Gold Coast, Queensland 4215, Australia.
Mahalingam S; Institute for Glycomics, Griffith University, Gold Coast, Queensland 4215, Australia.
Ong LC; Infectious Disease Programme, Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, and Immunology Programme, Life Sciences Institute, National University of Singapore, Singapore.
Alonso S; Infectious Disease Programme, Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, and Immunology Programme, Life Sciences Institute, National University of Singapore, Singapore.
Gordon DL; SA Pathology, Adelaide 5000, South Australia.; Microbiology and Infectious Diseases, Flinders University, Bedford Park, Adelaide 5042, South Australia.
Carr JM; Microbiology and Infectious Diseases, Flinders University, Bedford Park, Adelaide 5042, South Australia.
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Źródło :
The Journal of general virology [J Gen Virol] 2021 Mar; Vol. 102 (3). Date of Electronic Publication: 2021 Jan 07.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Complement Pathway, Alternative*
Complement Factor B/*metabolism
Complement Factor H/*metabolism
Dengue/*immunology
Severe Dengue/*immunology
Animals ; Antibody-Dependent Enhancement ; Complement Factor B/genetics ; Complement Factor H/genetics ; Dengue/virology ; Dengue Virus/immunology ; Dengue Virus/physiology ; Disease Models, Animal ; Humans ; Interferons/metabolism ; Mice ; Promoter Regions, Genetic ; Severe Dengue/virology ; Viremia
Czasopismo naukowe
Tytuł :
Complement activation is associated with crescent formation in IgA nephropathy.
Autorzy :
Itami H; Department of Diagnostic Pathology, Nara Medical University, 840 Shijo-Cho, Kashihara, Nara, Japan. .
Hara S; Department of Diagnostic Pathology, Kobe City Medical Center General Hospital, Kobe, Japan.
Samejima K; Department of Nephrology, Nara Medical University, Kashihara, Japan.
Tsushima H; Department of Nephrology, Nara Medical University, Kashihara, Japan.
Morimoto K; Department of Nephrology, Nara Prefecture General Medical Center, Nara, Japan.
Okamoto K; Department of Nephrology, Saiseikai Suita Hospital, Suita, Japan.
Kosugi T; Department of Nephrology, Nara Prefectural Seiwa Medical Center, Sango, Japan.
Kawano T; Department of Diabetes, Minami-Nara General Medical Center, Oyodo, Japan.
Fujiki K; Department of Diabetes, Minami-Nara General Medical Center, Oyodo, Japan.
Kitada H; Department of Internal Medicine, Saiseikai Chuwa Hospital, Sakurai, Japan.
Hatakeyama K; Department of Diagnostic Pathology, Nara Medical University, 840 Shijo-Cho, Kashihara, Nara, Japan.
Tsuruya K; Department of Nephrology, Nara Medical University, Kashihara, Japan.
Ohbayashi C; Department of Diagnostic Pathology, Nara Medical University, 840 Shijo-Cho, Kashihara, Nara, Japan.
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Źródło :
Virchows Archiv : an international journal of pathology [Virchows Arch] 2020 Oct; Vol. 477 (4), pp. 565-572. Date of Electronic Publication: 2020 Apr 16.
Typ publikacji :
Journal Article; Multicenter Study
MeSH Terms :
Complement Activation*
Complement System Proteins/*analysis
Glomerulonephritis, IGA/*immunology
Immunoglobulin A/*analysis
Kidney Glomerulus/*immunology
Adolescent ; Adult ; Aged ; Aged, 80 and over ; Complement C3/analysis ; Complement Factor B/analysis ; Complement Membrane Attack Complex/analysis ; Female ; Fluorescent Antibody Technique ; Glomerulonephritis, IGA/pathology ; Humans ; Immunoglobulin Light Chains/analysis ; Japan ; Kidney Glomerulus/pathology ; Male ; Mannose-Binding Protein-Associated Serine Proteases/analysis ; Microscopy, Fluorescence ; Middle Aged ; Properdin/analysis ; Retrospective Studies ; Young Adult
Czasopismo naukowe
Tytuł :
SARS-CoV-2 drives JAK1/2-dependent local complement hyperactivation.
Autorzy :
Yan B; Department of Biochemistry, Purdue University, West Lafayette, IN, USA.
Freiwald T; Immunoregulation Section, Kidney Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), NIH, Bethesda, MD, USA.; Complement and Inflammation Research Section (CIRS), National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH), Bethesda, MD, USA.; Department of Nephrology, University Hospital Frankfurt, Goethe-University, Frankfurt, Germany.
Chauss D; Immunoregulation Section, Kidney Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), NIH, Bethesda, MD, USA.
Wang L; Department of Computer Science, Purdue University, West Lafayette, IN, USA.
West E; Complement and Inflammation Research Section (CIRS), National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH), Bethesda, MD, USA.
Mirabelli C; Department of Microbiology and Immunology, University of Michigan, Ann Arbor, MI, USA.
Zhang CJ; Department of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, MI, USA.
Nichols EM; GlaxoSmithKline, Stevenage, UK.
Malik N; GlaxoSmithKline, Stevenage, UK.
Gregory R; GlaxoSmithKline, Stevenage, UK.
Bantscheff M; GlaxoSmithKline, Stevenage, UK.
Ghidelli-Disse S; GlaxoSmithKline, Stevenage, UK.
Kolev M; GlaxoSmithKline, Stevenage, UK.
Frum T; Department of Internal Medicine, Gastroenterology, Michigan Medicine at the University of Michigan, Ann Arbor, MI, USA.
Spence JR; Department of Internal Medicine, Gastroenterology, Michigan Medicine at the University of Michigan, Ann Arbor, MI, USA.; Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI, USA.
Sexton JZ; Department of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, MI, USA.; Department of Internal Medicine, Gastroenterology, Michigan Medicine at the University of Michigan, Ann Arbor, MI, USA.
Alysandratos KD; Center for Regenerative Medicine of Boston University and Boston Medical Center, Boston, MA, 1702118, USA.; The Pulmonary Center and Department of Medicine, Boston University School of Medicine, Boston, MA, 02118, USA.
Kotton DN; Center for Regenerative Medicine of Boston University and Boston Medical Center, Boston, MA, 1702118, USA.; The Pulmonary Center and Department of Medicine, Boston University School of Medicine, Boston, MA, 02118, USA.
Pittaluga S; Laboratory of Pathology, Center for Cancer Research, National Cancer Institute (NCI), NIH, Bethesda, MD, USA.
Bibby J; Complement and Inflammation Research Section (CIRS), National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH), Bethesda, MD, USA.
Niyonzima N; Center of Molecular Inflammation Research (CEMIR), Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology (NTNU), 7491 Trondheim, Norway.
Olson MR; Department of Biological Sciences, Purdue University, West Lafayette, IN, USA.
Kordasti S; CRUK-KHP Centre, Comprehensive Cancer Centre, King's College London, London, UK.; Haematology Department, Guy's Hospital, London, UK.
Portilla D; Immunoregulation Section, Kidney Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), NIH, Bethesda, MD, USA.; Division of Nephrology and the Center for Immunity, Inflammation and Regenerative Medicine, University of Virginia, VA, USA.
Wobus CE; Department of Microbiology and Immunology, University of Michigan, Ann Arbor, MI, USA.
Laurence A; Nuffield Department of Medicine, University of Oxford, UK.
Lionakis MS; Fungal Pathogenesis Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, MD, USA.
Kemper C; Complement and Inflammation Research Section (CIRS), National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH), Bethesda, MD, USA. .; Institute for Systemic Inflammation Research, University of Lübeck, Lübeck, Germany.
Afzali B; Immunoregulation Section, Kidney Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), NIH, Bethesda, MD, USA. .
Kazemian M; Department of Biochemistry, Purdue University, West Lafayette, IN, USA. .; Department of Computer Science, Purdue University, West Lafayette, IN, USA.
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Źródło :
Science immunology [Sci Immunol] 2021 Apr 07; Vol. 6 (58).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Complement Activation*
MAP Kinase Signaling System*
COVID-19/*metabolism
Epithelial Cells/*metabolism
Janus Kinase 1/*metabolism
Janus Kinase 2/*metabolism
Lung/*metabolism
SARS-CoV-2/*metabolism
COVID-19/pathology ; Cell Line, Tumor ; Complement C3a/metabolism ; Complement Factor B/metabolism ; Epithelial Cells/pathology ; Humans ; Lung/pathology
Czasopismo naukowe
Tytuł :
COVID-19: A collision of complement, coagulation and inflammatory pathways.
Autorzy :
Chauhan AJ; Research and Innovation, Queen Alexandra Hospital, Portsmouth, UK.; Faculty of Science and Health, University of Portsmouth, Portsmouth, UK.; Respiratory Medicine, Queen Alexandra Hospital, Portsmouth, UK.
Wiffen LJ; Research and Innovation, Queen Alexandra Hospital, Portsmouth, UK.; Respiratory Medicine, Queen Alexandra Hospital, Portsmouth, UK.
Brown TP; Research and Innovation, Queen Alexandra Hospital, Portsmouth, UK.; Respiratory Medicine, Queen Alexandra Hospital, Portsmouth, UK.
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Źródło :
Journal of thrombosis and haemostasis : JTH [J Thromb Haemost] 2020 Sep; Vol. 18 (9), pp. 2110-2117. Date of Electronic Publication: 2020 Aug 27.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Blood Coagulation*
Complement Activation*
COVID-19/*immunology
Complement C3a/*metabolism
Complement C5a/*metabolism
Inflammation/*metabolism
Animals ; Atypical Hemolytic Uremic Syndrome/complications ; Atypical Hemolytic Uremic Syndrome/immunology ; COVID-19/complications ; COVID-19/pathology ; Complement Inactivating Agents/pharmacology ; Cytokines/metabolism ; Hemoglobinuria, Paroxysmal/complications ; Hemoglobinuria, Paroxysmal/immunology ; Homeostasis ; Humans ; Immunity, Innate ; Lung Diseases ; Lung Injury ; Signal Transduction
Czasopismo naukowe
Tytuł :
Mini-Factor H Modulates Complement-Dependent IL-6 and IL-10 Release in an Immune Cell Culture (PBMC) Model: Potential Benefits Against Cytokine Storm.
Autorzy :
Kozma GT; Nanomedicine Research and Education Center, Institute of Translational Medicine, Semmelweis University, Budapest, Hungary.; SeroScience LCC, Budapest, Hungary.
Mészáros T; Nanomedicine Research and Education Center, Institute of Translational Medicine, Semmelweis University, Budapest, Hungary.; SeroScience LCC, Budapest, Hungary.
Bakos T; Nanomedicine Research and Education Center, Institute of Translational Medicine, Semmelweis University, Budapest, Hungary.
Hennies M; TECOdevelopment GmbH, Rheinbach, Germany.
Bencze D; MTA-ELTE Complement Research Group, Eötvös Loránd Research Network (ELKH), Department of Immunology, ELTE Eötvös Loránd University, Budapest, Hungary.
Uzonyi B; MTA-ELTE Complement Research Group, Eötvös Loránd Research Network (ELKH), Department of Immunology, ELTE Eötvös Loránd University, Budapest, Hungary.
Győrffy B; Second Department of Bioinformatics and Pediatrics, Semmelweis University, Budapest, Hungary.; Lendület Cancer Biomarker Research Group, Institute of Enzymology, Research Centre for Natural Sciences, Budapest, Hungary.
Cedrone E; Nanotechnology Characterization Lab, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Frederick, MD, United States.
Dobrovolskaia MA; Nanotechnology Characterization Lab, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Frederick, MD, United States.
Józsi M; MTA-ELTE Complement Research Group, Eötvös Loránd Research Network (ELKH), Department of Immunology, ELTE Eötvös Loránd University, Budapest, Hungary.; Department of Immunology, ELTE Eötvös Loránd University, Budapest, Hungary.
Szebeni J; Nanomedicine Research and Education Center, Institute of Translational Medicine, Semmelweis University, Budapest, Hungary.; SeroScience LCC, Budapest, Hungary.; Department of Nanobiotechnology and Regenerative Medicine, Faculty of Health, Miskolc University, Miskolc, Hungary.
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Źródło :
Frontiers in immunology [Front Immunol] 2021 Apr 28; Vol. 12, pp. 642860. Date of Electronic Publication: 2021 Apr 28 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Complement Activation*
Models, Immunological*
COVID-19/*immunology
Cytokine Release Syndrome/*immunology
Interleukin-10/*immunology
Interleukin-6/*immunology
Leukocytes, Mononuclear/*immunology
SARS-CoV-2/*immunology
COVID-19/pathology ; Complement Factor H/immunology ; Cytokine Release Syndrome/pathology ; Humans ; Leukocytes, Mononuclear/pathology ; Leukocytes, Mononuclear/virology
Czasopismo naukowe
Tytuł :
Is the COVID-19 thrombotic catastrophe complement-connected?
Autorzy :
Conway EM; Centre for Blood Research, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada.; Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Pryzdial ELG; Centre for Blood Research, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada.; Canadian Blood Services, Centre for Innovation, University of British Columbia, Vancouver, British Columbia, Canada.; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
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Źródło :
Journal of thrombosis and haemostasis : JTH [J Thromb Haemost] 2020 Nov; Vol. 18 (11), pp. 2812-2822. Date of Electronic Publication: 2020 Sep 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Blood Coagulation*/drug effects
Complement Activation*/drug effects
COVID-19/*immunology
Complement System Proteins/*immunology
SARS-CoV-2/*immunology
Thrombosis/*immunology
Animals ; Anticoagulants/therapeutic use ; COVID-19/blood ; COVID-19/drug therapy ; COVID-19/virology ; Complement Inactivating Agents/therapeutic use ; Host-Pathogen Interactions ; Humans ; Thrombosis/blood ; Thrombosis/prevention & control ; Thrombosis/virology
Czasopismo naukowe
Tytuł :
Resveratrol binding to human complement fragment 5a ( C5a) may modulate the C5aR signaling axes.
Autorzy :
Mishra R; Chemical Biology Laboratory, School of Basic Sciences, Indian Institute of Technology Bhubaneswar, Bhubaneswar, Odisha, India.
Das A; Chemical Biology Laboratory, School of Basic Sciences, Indian Institute of Technology Bhubaneswar, Bhubaneswar, Odisha, India.
Rana S; Chemical Biology Laboratory, School of Basic Sciences, Indian Institute of Technology Bhubaneswar, Bhubaneswar, Odisha, India.
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Źródło :
Journal of biomolecular structure & dynamics [J Biomol Struct Dyn] 2021 Mar; Vol. 39 (5), pp. 1766-1780. Date of Electronic Publication: 2020 Mar 17.
Typ publikacji :
Journal Article
MeSH Terms :
Complement C5a*
Molecular Dynamics Simulation*
Humans ; Inflammation ; Receptor, Anaphylatoxin C5a ; Receptors, Complement ; Resveratrol ; Signal Transduction
Czasopismo naukowe
Tytuł :
Nanobodies Provide Insight into the Molecular Mechanisms of the Complement Cascade and Offer New Therapeutic Strategies.
Autorzy :
Zarantonello A; Department of Molecular Biology and Genetics, Aarhus University, 8000 Aarhus, Denmark.
Pedersen H; Department of Molecular Biology and Genetics, Aarhus University, 8000 Aarhus, Denmark.
Laursen NS; Department of Biomedicine, Aarhus University, 8000 Aarhus, Denmark.
Andersen GR; Department of Molecular Biology and Genetics, Aarhus University, 8000 Aarhus, Denmark.
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Źródło :
Biomolecules [Biomolecules] 2021 Feb 17; Vol. 11 (2). Date of Electronic Publication: 2021 Feb 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Complement Activation*
Complement System Proteins*
Nanomedicine/*methods
Single-Domain Antibodies/*chemistry
Animals ; Antibodies, Monoclonal, Humanized/therapeutic use ; Atypical Hemolytic Uremic Syndrome/drug therapy ; Atypical Hemolytic Uremic Syndrome/immunology ; Complement C1/chemistry ; Complement C3-C5 Convertases/chemistry ; Epitopes/chemistry ; Hemoglobinuria, Paroxysmal/drug therapy ; Hemoglobinuria, Paroxysmal/immunology ; Humans ; Immunity, Innate ; Immunoglobulin G/immunology ; Inflammation ; Molecular Conformation ; Protein Binding ; Proteolysis
Czasopismo naukowe
Tytuł :
Dengue virus and the complement alternative pathway.
Autorzy :
Carr JM; College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia.
Cabezas-Falcon S; College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia.; TGR Biosciences, Adelaide, SA, Australia.
Dubowsky JG; College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia.
Hulme-Jones J; College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia.
Gordon DL; College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia.; SA Pathology, Flinders Medical Centre, Adelaide, SA, Australia.
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Źródło :
FEBS letters [FEBS Lett] 2020 Aug; Vol. 594 (16), pp. 2543-2555. Date of Electronic Publication: 2020 Jan 24.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Complement Pathway, Alternative*
Complement Factor D/*immunology
Complement Factor H/*immunology
Dengue/*immunology
Dengue Virus/*immunology
Animals ; Atypical Hemolytic Uremic Syndrome/immunology ; Atypical Hemolytic Uremic Syndrome/pathology ; Complement Factor H/deficiency ; Dengue/pathology ; Endothelial Cells/immunology ; Endothelial Cells/pathology ; Hereditary Complement Deficiency Diseases/immunology ; Hereditary Complement Deficiency Diseases/pathology ; Humans ; Kidney Diseases/immunology ; Kidney Diseases/pathology ; Macrophages/immunology ; Macrophages/pathology
SCR Disease Name :
Complement Factor H Deficiency
Czasopismo naukowe
Tytuł :
Serum Complement C3 and C4 and COVID-19 Severity and Mortality: A Systematic Review and Meta-Analysis With Meta-Regression.
Autorzy :
Zinellu A; Department of Biomedical Sciences, University of Sassari, Sassari, Italy.
Mangoni AA; Discipline of Clinical Pharmacology, College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia.; Department of Clinical Pharmacology, Flinders Medical Centre, Southern Adelaide Local Health Network, Adelaide, SA, Australia.
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Źródło :
Frontiers in immunology [Front Immunol] 2021 Jun 07; Vol. 12, pp. 696085. Date of Electronic Publication: 2021 Jun 07 (Print Publication: 2021).
Typ publikacji :
Meta-Analysis; Systematic Review
MeSH Terms :
COVID-19/*blood
Complement C3/*metabolism
Complement C4/*metabolism
Biomarkers/blood ; COVID-19/mortality ; COVID-19/pathology ; Complement Activation ; Humans ; SARS-CoV-2 ; Severity of Illness Index
Raport
Tytuł :
Circulating FH Protects Kidneys From Tubular Injury During Systemic Hemolysis.
Autorzy :
Merle NS; Centre de Recherche des Cordeliers, INSERM, Sorbonne Université, Université de Paris, Paris, France.
Leon J; Centre de Recherche des Cordeliers, INSERM, Sorbonne Université, Université de Paris, Paris, France.
Poillerat V; Centre de Recherche des Cordeliers, INSERM, Sorbonne Université, Université de Paris, Paris, France.
Grunenwald A; Centre de Recherche des Cordeliers, INSERM, Sorbonne Université, Université de Paris, Paris, France.
Boudhabhay I; Centre de Recherche des Cordeliers, INSERM, Sorbonne Université, Université de Paris, Paris, France.
Knockaert S; Centre de Recherche des Cordeliers, INSERM, Sorbonne Université, Université de Paris, Paris, France.
Robe-Rybkine T; Centre de Recherche des Cordeliers, INSERM, Sorbonne Université, Université de Paris, Paris, France.
Torset C; Centre de Recherche des Cordeliers, INSERM, Sorbonne Université, Université de Paris, Paris, France.
Pickering MC; Centre for Complement and Inflammation Research, Imperial College London, London, United Kingdom.
Chauvet S; Centre de Recherche des Cordeliers, INSERM, Sorbonne Université, Université de Paris, Paris, France.; Assistance Publique - Hôpitaux de Paris, Service de Nephrologie, Hôpital Européen Georges Pompidou, Paris, France.
Fremeaux-Bacchi V; Centre de Recherche des Cordeliers, INSERM, Sorbonne Université, Université de Paris, Paris, France.; Assistance Publique - Hôpitaux de Paris, Service d'Immunologie Biologique, Hôpital Européen Georges Pompidou, Paris, France.
Roumenina LT; Centre de Recherche des Cordeliers, INSERM, Sorbonne Université, Université de Paris, Paris, France.
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Źródło :
Frontiers in immunology [Front Immunol] 2020 Aug 07; Vol. 11, pp. 1772. Date of Electronic Publication: 2020 Aug 07 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Complement Activation*
Hemolysis*
Complement Factor H/*metabolism
Hepatocytes/*metabolism
Kidney Glomerulus/*metabolism
Kidney Tubular Necrosis, Acute/*prevention & control
Kidney Tubules/*metabolism
Animals ; Complement C5a/genetics ; Complement C5a/metabolism ; Complement Factor H/genetics ; Disease Models, Animal ; Gene Expression Regulation ; Kidney Glomerulus/pathology ; Kidney Tubular Necrosis, Acute/blood ; Kidney Tubular Necrosis, Acute/chemically induced ; Kidney Tubular Necrosis, Acute/pathology ; Kidney Tubules/pathology ; Mice, Inbred C57BL ; Mice, Knockout ; Phenylhydrazines ; Receptor, Anaphylatoxin C5a/genetics ; Receptor, Anaphylatoxin C5a/metabolism ; Signal Transduction
Czasopismo naukowe
Tytuł :
Inhibition of the Complement Alternative Pathway by Chemically Modified DNA Aptamers That Bind with Picomolar Affinity to Factor B.
Autorzy :
Xu X; Department of Biochemistry and Molecular Biophysics, Kansas State University, Manhattan, KS 66506.
Zhang C; SomaLogic, Inc., Boulder, CO 80301; and.
Denton DT; Department of Biochemistry and Molecular Biophysics, Kansas State University, Manhattan, KS 66506.
O'Connell D; St. Andrew's School, Middletown, DE 19709.
Drolet DW; SomaLogic, Inc., Boulder, CO 80301; and.
Geisbrecht BV; Department of Biochemistry and Molecular Biophysics, Kansas State University, Manhattan, KS 66506; .
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Źródło :
Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2021 Feb 15; Vol. 206 (4), pp. 861-873. Date of Electronic Publication: 2021 Jan 08.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Aptamers, Nucleotide*/chemistry
Aptamers, Nucleotide*/immunology
Complement Factor B*/chemistry
Complement Factor B*/immunology
Complement Pathway, Alternative*
Complement C3/chemistry ; Complement C3/immunology ; Humans
Czasopismo naukowe
Tytuł :
Complement activity is regulated in C3 glomerulopathy by IgG-factor H fusion proteins with and without properdin targeting domains.
Autorzy :
Gilmore AC; Centre for Inflammatory Disease, Imperial College London, UK.
Zhang Y; Alexion Pharmaceuticals, New Haven, Connecticut, USA.
Cook HT; Centre for Inflammatory Disease, Imperial College London, UK.
Lavin DP; Centre for Inflammatory Disease, Imperial College London, UK.
Katti S; Alexion Pharmaceuticals, New Haven, Connecticut, USA.
Wang Y; Alexion Pharmaceuticals, New Haven, Connecticut, USA.
Johnson KK; Alexion Pharmaceuticals, New Haven, Connecticut, USA.
Kim S; Alexion Pharmaceuticals, New Haven, Connecticut, USA.
Pickering MC; Centre for Inflammatory Disease, Imperial College London, UK. Electronic address: .
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Źródło :
Kidney international [Kidney Int] 2021 Feb; Vol. 99 (2), pp. 396-404. Date of Electronic Publication: 2020 Oct 28.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Complement C3*/genetics
Properdin*/genetics
Animals ; Complement C3-C5 Convertases ; Complement C5 ; Complement Factor H/genetics ; Complement Pathway, Alternative ; Immunoglobulin G ; Mice
Czasopismo naukowe
Tytuł :
COVID-19 vaccines induce severe hemolysis in paroxysmal nocturnal hemoglobinuria.
Autorzy :
Gerber GF; Division of Hematology, Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD; and.
Yuan X; Division of Hematology, Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD; and.
Yu J; Division of Hematology, Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD; and.
Cher BAY; University of Michigan Medical School, Ann Arbor, MI.
Braunstein EM; Division of Hematology, Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD; and.
Chaturvedi S; Division of Hematology, Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD; and.
Brodsky RA; Division of Hematology, Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD; and.
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Źródło :
Blood [Blood] 2021 Jul 01; Vol. 137 (26), pp. 3670-3673.
Typ publikacji :
Case Reports; Letter; Research Support, N.I.H., Extramural
MeSH Terms :
COVID-19*
SARS-CoV-2*
Anemia, Hemolytic/*etiology
COVID-19 Vaccines/*adverse effects
Complement Pathway, Alternative/*drug effects
Hemoglobinuria, Paroxysmal/*blood
Hemolysis/*drug effects
Spike Glycoprotein, Coronavirus/*adverse effects
Adult ; Anemia, Hemolytic/prevention & control ; Antibodies, Monoclonal, Humanized/therapeutic use ; Binding, Competitive ; Clone Cells ; Complement Factor D/antagonists & inhibitors ; Complement Factor H/metabolism ; Complement Inactivating Agents/therapeutic use ; Erythrocytes/drug effects ; Female ; Hemoglobinuria, Paroxysmal/drug therapy ; Heparitin Sulfate/metabolism ; Humans ; Male ; Middle Aged ; Protein Subunits ; Spike Glycoprotein, Coronavirus/metabolism ; Spike Glycoprotein, Coronavirus/pharmacology
Raport
Tytuł :
SARS-CoV-2 associated Complement genetic variants possibly deregulate the activation of the Alternative pathway affecting the severity of infection.
Autorzy :
Tsiftsoglou SA; Laboratory of Pharmacology, Department of Pharmaceutical Sciences, Aristotle University of Thessaloniki, Thessaloniki, 54124, Greece. Electronic address: .
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Źródło :
Molecular immunology [Mol Immunol] 2021 Jul; Vol. 135, pp. 421-425. Date of Electronic Publication: 2021 Mar 26.
Typ publikacji :
Letter; Review
MeSH Terms :
COVID-19*/genetics
COVID-19*/immunology
Complement System Proteins*/genetics
Complement System Proteins*/immunology
Genetic Variation*
Complement Pathway, Alternative/*genetics
SARS-CoV-2/*immunology
Humans
Recenzja
Tytuł :
Complement System and Potential Therapeutics in Age-Related Macular Degeneration.
Autorzy :
Park YG; Department of Ophthalmology and Visual Science, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.
Park YS; Department of Anatomy, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.
Kim IB; Department of Anatomy, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.; Catholic Neuroscience Institute, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.; Catholic Institute for Applied Anatomy, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jun 25; Vol. 22 (13). Date of Electronic Publication: 2021 Jun 25.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Complement System Proteins/*immunology
Macular Degeneration/*etiology
Clinical Trials as Topic ; Complement Activation/drug effects ; Complement System Proteins/metabolism ; Diagnostic Imaging ; Disease Management ; Disease Susceptibility ; Humans ; Macular Degeneration/diagnosis ; Macular Degeneration/metabolism ; Macular Degeneration/therapy ; Molecular Targeted Therapy ; Risk Factors ; Treatment Outcome
Czasopismo naukowe

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