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Tytuł:
Inhibition of complement C3 prevents osteoarthritis progression in guinea pigs by blocking STAT1 activation.
Autorzy:
Xu JX; Department of Drug Discovery and Biomedical Sciences, Medical University of South Carolina, 70 President Street, Charleston, SC, 29425, USA. .
Xu FZ; Department of Drug Discovery and Biomedical Sciences, Medical University of South Carolina, 70 President Street, Charleston, SC, 29425, USA.; UAB Heersink School of Medicine, Alabama, AL, 35233, USA.
Furbish A; Department of Drug Discovery and Biomedical Sciences, Medical University of South Carolina, 70 President Street, Charleston, SC, 29425, USA.
Braxton AM; Department of Comparative Medicine, Medical University of South Carolina, 114 Doughty Street, Charleston, SC, 29425, USA.
Brumfield B; Department of Drug Discovery and Biomedical Sciences, Medical University of South Carolina, 70 President Street, Charleston, SC, 29425, USA.
Helke KL; Department of Comparative Medicine, Medical University of South Carolina, 114 Doughty Street, Charleston, SC, 29425, USA.
Peterson YK; Department of Drug Discovery and Biomedical Sciences, Medical University of South Carolina, 70 President Street, Charleston, SC, 29425, USA. .
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Źródło:
Communications biology [Commun Biol] 2024 Mar 27; Vol. 7 (1), pp. 370. Date of Electronic Publication: 2024 Mar 27.
Typ publikacji:
Journal Article
MeSH Terms:
Complement C3*/metabolism
Complement C3*/therapeutic use
Osteoarthritis*/prevention & control
Osteoarthritis*/drug therapy
Osteoarthritis*/metabolism
Adult ; Humans ; Guinea Pigs ; Animals ; Quality of Life ; Interleukin-1beta/metabolism ; Synovial Fluid ; STAT1 Transcription Factor/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Serum Uric Acid Associates with Systemic Complement C3 Activation in Severe ANCA-Associated Renal Vasculitides.
Autorzy:
Baier E; Department of Nephrology and Rheumatology, University Medical Center Göttingen, 37075 Göttingen, Germany.
Kluge IA; Institute of Pathology, University Medical Center Göttingen, 37075 Göttingen, Germany.
Hakroush S; Institute of Pathology, University Medical Center Göttingen, 37075 Göttingen, Germany.; SYNLAB Pathology Hannover, SYNLAB Holding Germany, 86156 Augsburg, Germany.; Institute of Pathology, Klinikum Bremen-Mitte, School of Medicine of the University of Göttingen, 28205 Bremen, Germany.
Korsten P; Department of Rheumatology and Clinical Immunology, St. Josef-Stift Sendenhorst, 48324 Sendenhorst, Germany.
Tampe B; Department of Nephrology and Rheumatology, University Medical Center Göttingen, 37075 Göttingen, Germany.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Jan 05; Vol. 25 (2). Date of Electronic Publication: 2024 Jan 05.
Typ publikacji:
Journal Article
MeSH Terms:
Complement C3*
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis*
Humans ; Uric Acid ; Antibodies, Antineutrophil Cytoplasmic ; Retrospective Studies
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Initiation of the alternative pathway of complement and the history of "tickover".
Autorzy:
Pangburn MK; Center for Biomedical Research, University of Texas Health Science Center, Tyler, Texas, USA.
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Źródło:
Immunological reviews [Immunol Rev] 2023 Jan; Vol. 313 (1), pp. 64-70. Date of Electronic Publication: 2022 Sep 11.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Complement C3*/metabolism
Complement C3b*/metabolism
Humans ; Complement Activation ; Antibodies ; Sulfur Compounds ; Complement Pathway, Alternative
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
C3-dependent effector functions of complement.
Autorzy:
Zarantonello A; Centre de Recherche des Cordeliers, INSERM, Sorbonne Université, Université de Paris, Paris, France.
Revel M; Centre de Recherche des Cordeliers, INSERM, Sorbonne Université, Université de Paris, Paris, France.
Grunenwald A; Centre de Recherche des Cordeliers, INSERM, Sorbonne Université, Université de Paris, Paris, France.
Roumenina LT; Centre de Recherche des Cordeliers, INSERM, Sorbonne Université, Université de Paris, Paris, France.
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Źródło:
Immunological reviews [Immunol Rev] 2023 Jan; Vol. 313 (1), pp. 120-138. Date of Electronic Publication: 2022 Oct 22.
Typ publikacji:
Journal Article; Review; Research Support, Non-U.S. Gov't
MeSH Terms:
Complement C3*/analysis
Complement C3*/metabolism
Complement C3b*/metabolism
Humans ; Receptors, Complement/analysis ; Binding Sites ; Complement Activation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Complement C3-Deficiency-Induced Constipation in FVB/N-C3 /Korl Knockout Mice Was Significantly Relieved by Uridine and Liriope platyphylla L. Extracts.
Autorzy:
Song HJ; Department of Biomaterials Science (BK21 FOUR Program)/Life and Industry Convergence Research Institute/Laboratory Animals Resources Center, College of Natural Resources and Life Science, Pusan National University, Miryang 50463, Republic of Korea.
Kim JE; Department of Biomaterials Science (BK21 FOUR Program)/Life and Industry Convergence Research Institute/Laboratory Animals Resources Center, College of Natural Resources and Life Science, Pusan National University, Miryang 50463, Republic of Korea.
Jin YJ; Department of Biomaterials Science (BK21 FOUR Program)/Life and Industry Convergence Research Institute/Laboratory Animals Resources Center, College of Natural Resources and Life Science, Pusan National University, Miryang 50463, Republic of Korea.
Roh YJ; Department of Biomaterials Science (BK21 FOUR Program)/Life and Industry Convergence Research Institute/Laboratory Animals Resources Center, College of Natural Resources and Life Science, Pusan National University, Miryang 50463, Republic of Korea.
Seol A; Department of Biomaterials Science (BK21 FOUR Program)/Life and Industry Convergence Research Institute/Laboratory Animals Resources Center, College of Natural Resources and Life Science, Pusan National University, Miryang 50463, Republic of Korea.
Kim TR; Department of Biomaterials Science (BK21 FOUR Program)/Life and Industry Convergence Research Institute/Laboratory Animals Resources Center, College of Natural Resources and Life Science, Pusan National University, Miryang 50463, Republic of Korea.
Park KH; Department of Biomaterials Science (BK21 FOUR Program)/Life and Industry Convergence Research Institute/Laboratory Animals Resources Center, College of Natural Resources and Life Science, Pusan National University, Miryang 50463, Republic of Korea.
Park ES; Department of Biomaterials Science (BK21 FOUR Program)/Life and Industry Convergence Research Institute/Laboratory Animals Resources Center, College of Natural Resources and Life Science, Pusan National University, Miryang 50463, Republic of Korea.
An BS; Department of Biomaterials Science (BK21 FOUR Program)/Life and Industry Convergence Research Institute/Laboratory Animals Resources Center, College of Natural Resources and Life Science, Pusan National University, Miryang 50463, Republic of Korea.
Yang SY; Department of Biomaterials Science (BK21 FOUR Program)/Life and Industry Convergence Research Institute/Laboratory Animals Resources Center, College of Natural Resources and Life Science, Pusan National University, Miryang 50463, Republic of Korea.
Seo S; Department of Biomaterials Science (BK21 FOUR Program)/Life and Industry Convergence Research Institute/Laboratory Animals Resources Center, College of Natural Resources and Life Science, Pusan National University, Miryang 50463, Republic of Korea.
Jo SM; Department of Biomaterials Science (BK21 FOUR Program)/Life and Industry Convergence Research Institute/Laboratory Animals Resources Center, College of Natural Resources and Life Science, Pusan National University, Miryang 50463, Republic of Korea.
Jung YS; College of Pharmacy, Pusan National University, Busan 46241, Republic of Korea.
Hwang DY; Department of Biomaterials Science (BK21 FOUR Program)/Life and Industry Convergence Research Institute/Laboratory Animals Resources Center, College of Natural Resources and Life Science, Pusan National University, Miryang 50463, Republic of Korea.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Oct 30; Vol. 24 (21). Date of Electronic Publication: 2023 Oct 30.
Typ publikacji:
Journal Article
MeSH Terms:
Complement C3*
Plant Extracts*/pharmacology
Plant Extracts*/therapeutic use
Plant Extracts*/chemistry
Mice ; Animals ; Mice, Knockout ; Uridine/pharmacology ; Uridine/therapeutic use ; Constipation/drug therapy ; Constipation/chemically induced ; Mucins ; Water
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The correlation of anxiety and depression with C3 and C4 Levels and systemic lupus erythematosus activity.
Autorzy:
Shatri H; Division of Psychosomatic and Palliative, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia/ Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia. .
Purnamandala; Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia/ Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia.
Hidayat R; Division of Rheumatology, Department of Internal, Faculty of Medicine, Universitas Indonesia/ Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia.
Sinto R; Division of Tropical and Infectious Diseases, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia/ Cipto Mangunkusumo Referral National Hospital, Jakarta, Indonesia.
Widhani A; Division of Allergy and Clinical Immunology, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia/ Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia.
Putranto R; Division of Psychosomatic and Palliative, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia/ Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia.
Purnamasari RD; Division of Endocrinology Metabolism and Diabetes, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia/ Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia.
Ginanjar E; Division of Cardiology, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia/ Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia.
Jasirwan COM; Division oh Hepatobiliary, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia/ Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia.
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Źródło:
BMC psychiatry [BMC Psychiatry] 2023 Oct 26; Vol. 23 (1), pp. 785. Date of Electronic Publication: 2023 Oct 26.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Complement C3*/analysis
Lupus Erythematosus, Systemic*/complications
Lupus Erythematosus, Systemic*/diagnosis
Humans ; Quality of Life ; Depression/psychology ; Cross-Sectional Studies ; Anxiety/psychology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Activation of complement C1q and C3 in glomeruli might accelerate the progression of diabetic nephropathy: Evidence from transcriptomic data and renal histopathology.
Autorzy:
Jiao Y; Department of Nephrology, China-Japan Friendship Hospital, Beijing, China.; Graduate School of Peking Union Medical College, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.
Jiang S; Department of Nephrology, China-Japan Friendship Hospital, Beijing, China.
Wang Y; Department of Nephrology, China-Japan Friendship Hospital, Beijing, China.; Graduate School of Peking Union Medical College, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.
Yu T; Department of Nephrology, China-Japan Friendship Hospital, Beijing, China.
Zou G; Department of Nephrology, China-Japan Friendship Hospital, Beijing, China.
Zhuo L; Department of Nephrology, China-Japan Friendship Hospital, Beijing, China.
Li W; Department of Nephrology, China-Japan Friendship Hospital, Beijing, China.; Graduate School of Peking Union Medical College, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.
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Źródło:
Journal of diabetes investigation [J Diabetes Investig] 2022 May; Vol. 13 (5), pp. 839-849. Date of Electronic Publication: 2022 Jan 10.
Typ publikacji:
Journal Article
MeSH Terms:
Complement C1q*/genetics
Complement C1q*/metabolism
Complement C3*/genetics
Complement C3*/metabolism
Diabetes Mellitus*/genetics
Diabetes Mellitus*/metabolism
Diabetic Nephropathies*/genetics
Diabetic Nephropathies*/pathology
Renal Insufficiency*/complications
Complement System Proteins/genetics ; Complement System Proteins/metabolism ; Female ; Humans ; Kidney Glomerulus/metabolism ; Male ; Transcriptome
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Physiology and pathology of the C3 amplification cycle: A retrospective.
Autorzy:
Peters K; The Francis Crick Institute, London, UK.
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Źródło:
Immunological reviews [Immunol Rev] 2023 Jan; Vol. 313 (1), pp. 217-224. Date of Electronic Publication: 2022 Nov 21.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Complement C3*
Humans ; Retrospective Studies
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Marginal zone B cells acquire dendritic cell functions by trogocytosis.
Autorzy:
Schriek P; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, VIC 3010, Australia.
Ching AC; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, VIC 3010, Australia.
Moily NS; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, VIC 3010, Australia.
Moffat J; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, VIC 3010, Australia.
Beattie L; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, VIC 3010, Australia.
Steiner TM; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, VIC 3010, Australia.
Hosking LM; Department of Allergy and Immunology, Royal Children's Hospital, Parkville, VIC 3052, Australia.
Thurman JM; Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO 80045, USA.
Holers VM; Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO 80045, USA.
Ishido S; Department of Microbiology, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya 663-8501, Japan.
Lahoud MH; Monash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800, Australia.
Caminschi I; Monash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800, Australia.
Heath WR; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, VIC 3010, Australia.
Mintern JD; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, VIC 3010, Australia.
Villadangos JA; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, VIC 3010, Australia.; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, VIC 3010, Australia.
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Źródło:
Science (New York, N.Y.) [Science] 2022 Feb 11; Vol. 375 (6581), pp. eabf7470. Date of Electronic Publication: 2022 Feb 11.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Trogocytosis*
B-Lymphocytes/*immunology
Complement C3/*metabolism
Dendritic Cells/*immunology
Lymphoid Tissue/*immunology
Adult ; Animals ; Antigen Presentation ; B-Lymphocytes/metabolism ; Cell Membrane/metabolism ; Complement Activation ; Complement C3/immunology ; Dendritic Cells/metabolism ; Female ; HLA-D Antigens/immunology ; HLA-D Antigens/metabolism ; Histocompatibility Antigens Class II/metabolism ; Humans ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C3H ; Mice, Inbred C57BL ; Middle Aged ; Receptors, Complement 3d/immunology ; Receptors, Complement 3d/metabolism ; T-Lymphocytes/immunology ; Ubiquitin-Protein Ligases/genetics ; Ubiquitin-Protein Ligases/metabolism ; Ubiquitination
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Clinical relevance of glomerular IgM deposition in patients with lupus nephritis.
Autorzy:
Wang F; Institute of Nephrology, Zhong Da Hospital, Southeast University School of Medicine, Nanjing, China.
Yu J; Institute of Nephrology, Zhong Da Hospital, Southeast University School of Medicine, Nanjing, China.
Zhang L; Department of Nephrology, The Fifth Affiliated Hospital of Xinjiang Medical University, Urumqi, 830000, Xinjiang, China.
Zhang Y; Department of Nephrology, The Fifth Affiliated Hospital of Xinjiang Medical University, Urumqi, 830000, Xinjiang, China.
Zhang J; Department of Public Health, Aarhus University, Aarhus, Denmark.
Liu B; Institute of Nephrology, Zhong Da Hospital, Southeast University School of Medicine, Nanjing, China. .
Yang X; Department of Nephrology, Provincial Hospital Affiliated to Shandong University, Jinan, 250021, Shandong, China. .; Department of Nephrology, Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, Shandong, China. .
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Źródło:
BMC immunology [BMC Immunol] 2021 Dec 07; Vol. 22 (1), pp. 75. Date of Electronic Publication: 2021 Dec 07.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Complement C1q/*metabolism
Complement C3/*metabolism
Immunoglobulin M/*metabolism
Kidney Glomerulus/*metabolism
Lupus Nephritis/*immunology
Adult ; Cohort Studies ; Complement Activation ; Complement Factor H/metabolism ; Creatinine/blood ; Female ; Humans ; Kidney Glomerulus/pathology ; Male ; Proteinuria ; Young Adult
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Discovery of APL-1030, a Novel, High-Affinity Nanofitin Inhibitor of C3-Mediated Complement Activation.
Autorzy:
Garlich J; Apellis Pharmaceuticals, Waltham, MA 02451, USA.
Cinier M; Affilogic SAS, 44200 Nantes, France.
Chevrel A; Affilogic SAS, 44200 Nantes, France.
Perrocheau A; Affilogic SAS, 44200 Nantes, France.
Eyerman DJ; Apellis Pharmaceuticals, Waltham, MA 02451, USA.
Orme M; Apellis Pharmaceuticals, Waltham, MA 02451, USA.
Kitten O; Affilogic SAS, 44200 Nantes, France.
Scheibler L; Apellis Pharmaceuticals, Waltham, MA 02451, USA.
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Źródło:
Biomolecules [Biomolecules] 2022 Mar 11; Vol. 12 (3). Date of Electronic Publication: 2022 Mar 11.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Complement Activation*
Complement C3*/metabolism
Amino Acids ; Animals ; Binding Sites ; Crystallography, X-Ray
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
AMD-Like Substrate Causes Epithelial Mesenchymal Transition in iPSC-Derived Retinal Pigment Epithelial Cells Wild Type but Not C3 -Knockout.
Autorzy:
Chinchilla B; The Ocular Genomics Institute at Mass Eye and Ear, Harvard Medical School, Boston, MA 02114, USA.
Fernandez-Godino R; The Ocular Genomics Institute at Mass Eye and Ear, Harvard Medical School, Boston, MA 02114, USA.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Jul 30; Vol. 22 (15). Date of Electronic Publication: 2021 Jul 30.
Typ publikacji:
Journal Article
MeSH Terms:
Epithelial-Mesenchymal Transition*
Complement C3/*metabolism
Macular Degeneration/*metabolism
Retinal Pigment Epithelium/*metabolism
Cell Line ; Collagen/metabolism ; Complement Activation ; Complement C3/genetics ; Epithelial Cells/cytology ; Epithelial Cells/metabolism ; Extracellular Matrix/metabolism ; Humans ; Induced Pluripotent Stem Cells/cytology ; Retinal Pigment Epithelium/cytology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Dysregulation of the Enteric Nervous System in the Mid Colon of Complement Component 3 Knockout Mice with Constipation Phenotypes.
Autorzy:
Choi YJ; Department of Biomaterials Science (BK21 FOUR Program) and Life and Industry Convergence Research Institute, College of Natural Resources & LifeScience, Pusan National University, Miryang 50463, Korea.
Song HJ; Department of Biomaterials Science (BK21 FOUR Program) and Life and Industry Convergence Research Institute, College of Natural Resources & LifeScience, Pusan National University, Miryang 50463, Korea.
Kim JE; Department of Biomaterials Science (BK21 FOUR Program) and Life and Industry Convergence Research Institute, College of Natural Resources & LifeScience, Pusan National University, Miryang 50463, Korea.
Lee SJ; Department of Biomaterials Science (BK21 FOUR Program) and Life and Industry Convergence Research Institute, College of Natural Resources & LifeScience, Pusan National University, Miryang 50463, Korea.
Jin YJ; Department of Biomaterials Science (BK21 FOUR Program) and Life and Industry Convergence Research Institute, College of Natural Resources & LifeScience, Pusan National University, Miryang 50463, Korea.
Roh YJ; Department of Biomaterials Science (BK21 FOUR Program) and Life and Industry Convergence Research Institute, College of Natural Resources & LifeScience, Pusan National University, Miryang 50463, Korea.
Seol A; Department of Biomaterials Science (BK21 FOUR Program) and Life and Industry Convergence Research Institute, College of Natural Resources & LifeScience, Pusan National University, Miryang 50463, Korea.
Kim HS; Department of Nanomechatronics Engineering, College of Nanoscience & Nanotechnology, Pusan National University, Miryang 50463, Korea.
Hwang DY; Department of Biomaterials Science (BK21 FOUR Program) and Life and Industry Convergence Research Institute, College of Natural Resources & LifeScience, Pusan National University, Miryang 50463, Korea.; Laboratory Animals Resources Center, Pusan National University, Miryang 50463, Korea.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Jun 20; Vol. 23 (12). Date of Electronic Publication: 2022 Jun 20.
Typ publikacji:
Journal Article
MeSH Terms:
Complement C3*
Enteric Nervous System*/physiology
Animals ; Colon/physiology ; Constipation/genetics ; Mice ; Mice, Knockout ; Phenotype ; Serotonin
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Molecular basis of complement factor I deficiency in Tunisian atypical haemolytic and uraemic syndrome patients.
Autorzy:
Jlajla H; Department of Immunology, La Rabta Hospital, Tunis, Tunisia.; Research Laboratory of Immuno-Rheumatology (LR05 SP01), La Rabta Hospital, Tunis, Tunisia.; Faculty of Sciences, Carthage University, Bizerte, Tunisia.
Dehman F; Department of Immunology, La Rabta Hospital, Tunis, Tunisia.; Research Laboratory of Immuno-Rheumatology (LR05 SP01), La Rabta Hospital, Tunis, Tunisia.
Jallouli M; Department of Paediatrics, Charles Nicolle Hospital, Tunis, Tunisia.
Khedher R; Department of Nephrology, La Rabta Hospital, Tunis, Tunisia.
Ayadi I; Department of Immunology, La Rabta Hospital, Tunis, Tunisia.; Research Laboratory of Immuno-Rheumatology (LR05 SP01), La Rabta Hospital, Tunis, Tunisia.; Faculty of Medicine, El Manar University, Tunis, Tunisia.
Zerzeri Y; Department of Immunology, La Rabta Hospital, Tunis, Tunisia.; Research Laboratory of Immuno-Rheumatology (LR05 SP01), La Rabta Hospital, Tunis, Tunisia.
Laadhar L; Department of Immunology, La Rabta Hospital, Tunis, Tunisia.; Research Laboratory of Immuno-Rheumatology (LR05 SP01), La Rabta Hospital, Tunis, Tunisia.; Faculty of Medicine, El Manar University, Tunis, Tunisia.
Sfar I; Faculty of Medicine, El Manar University, Tunis, Tunisia.; Department of Immunology, Charles Nicolle Hospital, Tunis, Tunisia.
Mahfoudh A; Department of Paediatrics, Hedi Chaker Hospital, Sfax, Tunisia.
Gorgi Y; Faculty of Medicine, El Manar University, Tunis, Tunisia.; Department of Immunology, Charles Nicolle Hospital, Tunis, Tunisia.
Cheour E; Research Laboratory of Immuno-Rheumatology (LR05 SP01), La Rabta Hospital, Tunis, Tunisia.
Zouaghi K; Faculty of Medicine, El Manar University, Tunis, Tunisia.; Department of Nephrology, La Rabta Hospital, Tunis, Tunisia.
Gargah T; Faculty of Medicine, El Manar University, Tunis, Tunisia.; Department of Paediatrics, Charles Nicolle Hospital, Tunis, Tunisia.
Kallel Sellami M; Department of Immunology, La Rabta Hospital, Tunis, Tunisia.; Research Laboratory of Immuno-Rheumatology (LR05 SP01), La Rabta Hospital, Tunis, Tunisia.; Faculty of Medicine, El Manar University, Tunis, Tunisia.
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Źródło:
Nephrology (Carlton, Vic.) [Nephrology (Carlton)] 2019 Mar; Vol. 24 (3), pp. 357-364.
Typ publikacji:
Journal Article
MeSH Terms:
Atypical Hemolytic Uremic Syndrome*/diagnosis
Atypical Hemolytic Uremic Syndrome*/epidemiology
Atypical Hemolytic Uremic Syndrome*/genetics
Complement Factor I*/analysis
Complement Factor I*/genetics
Genetic Diseases, Inborn*/blood
Genetic Diseases, Inborn*/epidemiology
Genetic Diseases, Inborn*/genetics
Complement C3/*deficiency
Adult ; Child ; Child, Preschool ; Cohort Studies ; Complement C3/genetics ; Female ; Hereditary Complement Deficiency Diseases ; Humans ; Infant ; Male ; Mutation ; Polymorphism, Genetic ; Tunisia/epidemiology
SCR Disease Name:
Complement Factor I Deficiency
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Promotion of the inflammatory response in mid colon of complement component 3 knockout mice.
Autorzy:
Choi YJ; Department of Biomaterials Science (BK21 FOUR Program), College of Natural Resources and Life Science/Life and Industry Convergence Research Institute, Pusan National University, Miryang, 50463, Korea.
Kim JE; Department of Biomaterials Science (BK21 FOUR Program), College of Natural Resources and Life Science/Life and Industry Convergence Research Institute, Pusan National University, Miryang, 50463, Korea.
Lee SJ; Department of Biomaterials Science (BK21 FOUR Program), College of Natural Resources and Life Science/Life and Industry Convergence Research Institute, Pusan National University, Miryang, 50463, Korea.
Gong JE; Department of Biomaterials Science (BK21 FOUR Program), College of Natural Resources and Life Science/Life and Industry Convergence Research Institute, Pusan National University, Miryang, 50463, Korea.
Jin YJ; Department of Biomaterials Science (BK21 FOUR Program), College of Natural Resources and Life Science/Life and Industry Convergence Research Institute, Pusan National University, Miryang, 50463, Korea.
Lee H; Graduate School of Cancer Science and Policy, Research Institute, National Cancer Center, Goyang, 10408, Korea.
Hwang DY; Department of Biomaterials Science (BK21 FOUR Program), College of Natural Resources and Life Science/Life and Industry Convergence Research Institute, Pusan National University, Miryang, 50463, Korea. .; Longevity & Wellbeing Research Center/Laboratory Animals Resources Center, Pusan National University, Miryang, 50463, Korea. .; Department of Biomaterials Science (BK21 FOUR Program), College of Natural Resources and Life Science/Life and Industry Convergence Research Institute/Laboratory Animals Resources Center, Pusan National University, 1268-50 Samrangjin-ro, Samrangjin-eup, Miryang-si, Gyeongsangnam-do, 50463, Korea. .
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Źródło:
Scientific reports [Sci Rep] 2022 Feb 01; Vol. 12 (1), pp. 1700. Date of Electronic Publication: 2022 Feb 01.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
CARD Signaling Adaptor Proteins/*metabolism
Colitis/*metabolism
Complement C3/*metabolism
Cyclooxygenase 2/*metabolism
Cytokines/*metabolism
Inflammasomes/*metabolism
NF-kappa B/*metabolism
Nitric Oxide Synthase Type II/*metabolism
Signal Transduction/*genetics
Animals ; Apoptosis/genetics ; Colitis/genetics ; Complement C3/genetics ; Gene Knockout Techniques/methods ; Mice ; Mice, Knockout ; Phosphorylation/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
C3 levels and acute outcomes in Shiga toxin-related hemolytic uremic syndrome.
Autorzy:
Balestracci A; Nephrology Unit, Hospital General de Niños Pedro de Elizalde, Montes de Oca 40, CP - 1270, Autonomous City of Buenos Aires, Argentina. .
Meni Bataglia L; Nephrology Unit, Hospital General de Niños Pedro de Elizalde, Montes de Oca 40, CP - 1270, Autonomous City of Buenos Aires, Argentina.
Toledo I; Nephrology Unit, Hospital General de Niños Pedro de Elizalde, Montes de Oca 40, CP - 1270, Autonomous City of Buenos Aires, Argentina.
Beaudoin L; Nephrology Unit, Hospital General de Niños Pedro de Elizalde, Montes de Oca 40, CP - 1270, Autonomous City of Buenos Aires, Argentina.
Alvarado C; Nephrology Unit, Hospital General de Niños Pedro de Elizalde, Montes de Oca 40, CP - 1270, Autonomous City of Buenos Aires, Argentina.
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Źródło:
Pediatric nephrology (Berlin, Germany) [Pediatr Nephrol] 2020 Feb; Vol. 35 (2), pp. 331-339. Date of Electronic Publication: 2019 Sep 02.
Typ publikacji:
Journal Article
MeSH Terms:
Complement C3*
Escherichia coli Infections/*complications
Hemolytic-Uremic Syndrome/*blood
Hemolytic-Uremic Syndrome/*microbiology
Adolescent ; Child ; Child, Preschool ; Complement Activation ; Female ; Humans ; Infant ; Male ; Retrospective Studies ; Shiga-Toxigenic Escherichia coli
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Acadesine suppresses TNF-α induced complement component 3 (C3), in retinal pigment epithelial (RPE) cells.
Autorzy:
Efstathiou NE; Angiogenesis laboratory, Department of Ophthalmology, Retina Service, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, United States of America.
Moustafa GA; Angiogenesis laboratory, Department of Ophthalmology, Retina Service, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, United States of America.
Maidana DE; Angiogenesis laboratory, Department of Ophthalmology, Retina Service, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, United States of America.
Konstantinou EK; Angiogenesis laboratory, Department of Ophthalmology, Retina Service, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, United States of America.
Notomi S; Angiogenesis laboratory, Department of Ophthalmology, Retina Service, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, United States of America.
Barbisan PRT; Angiogenesis laboratory, Department of Ophthalmology, Retina Service, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, United States of America.
Georgakopoulos CD; Department of Ophthalmology, University of Patras, Medical School, Patras, Greece.
Miller JW; Angiogenesis laboratory, Department of Ophthalmology, Retina Service, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, United States of America.
Vavvas DG; Angiogenesis laboratory, Department of Ophthalmology, Retina Service, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, United States of America.
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Źródło:
PloS one [PLoS One] 2020 Dec 23; Vol. 15 (12), pp. e0244307. Date of Electronic Publication: 2020 Dec 23 (Print Publication: 2020).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Aminoimidazole Carboxamide/*analogs & derivatives
Complement C3/*metabolism
Retinal Pigment Epithelium/*metabolism
Ribonucleosides/*pharmacology
AMP-Activated Protein Kinases/metabolism ; Adenosine/metabolism ; Aminoimidazole Carboxamide/metabolism ; Aminoimidazole Carboxamide/pharmacology ; Animals ; Cell Line ; Cells, Cultured ; Complement Activation/drug effects ; Complement C3/drug effects ; Humans ; Macular Degeneration/metabolism ; Phosphorylation ; Retinal Pigment Epithelium/drug effects ; Retinal Pigments/metabolism ; Ribonucleosides/metabolism ; Ribonucleotides/pharmacology ; Tumor Necrosis Factor-alpha/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Kallikrein Cleaves C3 and Activates Complement.
Autorzy:
Irmscher S; Department of Infection Biology, Leibniz Institute for Natural Product Research and Infection Biology, Jena, Germany.
Döring N
Halder LD
Jo EAH
Kopka I
Dunker C
Jacobsen ID
Luo S
Slevogt H
Lorkowski S
Beyersdorf N
Zipfel PF
Skerka C
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Źródło:
Journal of innate immunity [J Innate Immun] 2018; Vol. 10 (2), pp. 94-105. Date of Electronic Publication: 2017 Dec 14.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Complement Activation*
Complement C3/*metabolism
Complement C3-C5 Convertases/*metabolism
Kallikreins/*metabolism
Amino Acid Sequence ; Animals ; Candida albicans/immunology ; Candidiasis/immunology ; Candidiasis/microbiology ; Cell Line, Transformed ; Complement C3b/chemistry ; Complement C3b/metabolism ; Complement Factor B/metabolism ; Complement Factor D/metabolism ; Complement Factor H/pharmacology ; Complement Pathway, Alternative ; Factor XII/metabolism ; Female ; Humans ; Immune Evasion ; Mice, Inbred BALB C ; Protein Binding/drug effects
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Proteome Profile of Trigeminal Ganglion in Murine Model of Allergic Contact Dermatitis: Complement 3 Pathway Contributes to Itch and Pain Sensation.
Autorzy:
Su W; Department of Anesthesiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Yu J; Department of Anesthesiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Zhang X; Department of Anesthesiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Ma L; Department of Anesthesiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. .
Huang Y; Department of Anesthesiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
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Źródło:
Neurotoxicity research [Neurotox Res] 2021 Oct; Vol. 39 (5), pp. 1564-1574. Date of Electronic Publication: 2021 Aug 21.
Typ publikacji:
Journal Article
MeSH Terms:
Complement C3/*metabolism
Dermatitis, Allergic Contact/*metabolism
Pain/*metabolism
Proteome/*metabolism
Pruritus/*metabolism
Trigeminal Ganglion/*metabolism
Animals ; Complement C3/genetics ; Dermatitis, Allergic Contact/genetics ; Disease Models, Animal ; Male ; Mice ; Mice, Inbred C57BL ; Pain/genetics ; Protein Interaction Maps/physiology ; Proteome/genetics ; Proteomics/methods ; Pruritus/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Is there relationship between SARS-CoV-2 and the complement C3 and C4?
Autorzy:
Dheir H; Division of Nephrology, Faculty of Medicine, Sakarya University, Sakarya, Turkey
Sipahi S; Division of Nephrology, Faculty of Medicine, Sakarya University, Sakarya, Turkey
Yaylaci S; Department of Internal Medicine, Faculty of Medicine, Sakarya University, Sakarya, Turkey
Köroğlu M; Department of Microbiology, Faculty of Medicine, Sakarya University, Sakarya, Turkey
Erdem AF; Department of Anesthesiology, Faculty of Medicine, Sakarya University, Sakarya, Turkey
Karabay O; Department of Infectious Diseases, Faculty of Medicine, Sakarya University, Sakarya, Turkey
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Źródło:
Turkish journal of medical sciences [Turk J Med Sci] 2020 Jun 23; Vol. 50 (4), pp. 687-688. Date of Electronic Publication: 2020 Jun 23.
Typ publikacji:
Letter
MeSH Terms:
Complement Activation*
COVID-19/*blood
Complement C3/*metabolism
Complement C4/*metabolism
COVID-19/immunology ; COVID-19/virology ; Humans ; Intensive Care Units ; SARS-CoV-2
Opinia redakcyjna
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Wyświetlanie 1-20 z 1366

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