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Tytuł:
Modelling and analysis of cAMP-induced mixed-mode oscillations in cortical neurons: Critical roles of HCN and M-type potassium channels.
Autorzy:
Martin M; Department of Information Engineering, University of Padova, Padova, Italy.
Pedersen MG; Department of Information Engineering, University of Padova, Padova, Italy.
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Źródło:
PLoS computational biology [PLoS Comput Biol] 2024 Mar 22; Vol. 20 (3), pp. e1011559. Date of Electronic Publication: 2024 Mar 22 (Print Publication: 2024).
Typ publikacji:
Journal Article
MeSH Terms:
Potassium Channels*/chemistry
Nucleotides, Cyclic*/pharmacology
Neurons ; Cyclic AMP ; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels/physiology ; Cyclic Nucleotide-Gated Cation Channels
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Elevated PDE4C level serves as a candidate diagnostic biomarker and correlates with poor survival in thyroid carcinoma.
Autorzy:
Wang Y; Department of Laboratory Medicine, The First Hospital of Jilin University, Changchun, 130021, China.
Zhang Y; Center for Reproductive Medicine and Center for Prenatal Diagnosis, The First Hospital of Jilin University, Changchun, 130021, China.
Li Y; Department of Laboratory Medicine, The First Hospital of Jilin University, Changchun, 130021, China. .
Huang J; Department of Laboratory Medicine, The First Hospital of Jilin University, Changchun, 130021, China. .
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Źródło:
Scientific reports [Sci Rep] 2024 Mar 21; Vol. 14 (1), pp. 6813. Date of Electronic Publication: 2024 Mar 21.
Typ publikacji:
Journal Article
MeSH Terms:
Cyclic Nucleotide Phosphodiesterases, Type 4*/genetics
Cyclic Nucleotide Phosphodiesterases, Type 4*/metabolism
Thyroid Neoplasms*/diagnosis
Thyroid Neoplasms*/genetics
Humans ; Cyclic AMP/metabolism ; Signal Transduction ; Biomarkers ; Tumor Microenvironment/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Nucleotides as Bacterial Second Messengers.
Autorzy:
Cancino-Diaz ME; Departamentos Microbiología and Inmunología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Manuel Carpio, Plutarco Elías Calles, Miguel Hidalgo, Ciudad de México 11350, Mexico.
Guerrero-Barajas C; Departamento de Bioprocesos, Unidad Profesional Interdisciplinaria de Biotecnología, Instituto Politécnico Nacional, Av. Acueducto, La Laguna Ticoman, Gustavo A. Madero, Ciudad de México 07340, Mexico.
Betanzos-Cabrera G; Área Académica de Nutrición y Medicina, Instituto de Ciencias de la Salud, Universidad Autónoma del Estado de Hidalgo, Carretera Pachuca-Actopan Camino a Tilcuautla s/n, Pueblo San Juan Tilcuautla, Pachuca Hidalgo 42160, Mexico.
Cancino-Diaz JC; Departamentos Microbiología and Inmunología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Manuel Carpio, Plutarco Elías Calles, Miguel Hidalgo, Ciudad de México 11350, Mexico.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2023 Dec 07; Vol. 28 (24). Date of Electronic Publication: 2023 Dec 07.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Second Messenger Systems*/physiology
Cyclic GMP*
Signal Transduction/physiology ; Bacteria ; Cyclic AMP ; Nucleotides, Cyclic ; Bacterial Proteins
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
PDE4 Phosphodiesterases in Cardiovascular Diseases: Key Pathophysiological Players and Potential Therapeutic Targets.
Autorzy:
Puertas-Umbert L; Institut de Recerca Sant Pau (IR SANT PAU), 08041 Barcelona, Spain.; CIBER de Enfermedades Cardiovasculares, Instituto de Salud Carlos III, 28029 Madrid, Spain.
Alonso J; Institut de Recerca Sant Pau (IR SANT PAU), 08041 Barcelona, Spain.; CIBER de Enfermedades Cardiovasculares, Instituto de Salud Carlos III, 28029 Madrid, Spain.; Instituto de Investigaciones Biomédicas de Barcelona-Consejo Superior de Investigaciones Científicas (IIBB-CSIC), 08036 Barcelona, Spain.
Hove-Madsen L; Institut de Recerca Sant Pau (IR SANT PAU), 08041 Barcelona, Spain.; CIBER de Enfermedades Cardiovasculares, Instituto de Salud Carlos III, 28029 Madrid, Spain.; Instituto de Investigaciones Biomédicas de Barcelona-Consejo Superior de Investigaciones Científicas (IIBB-CSIC), 08036 Barcelona, Spain.
Martínez-González J; Institut de Recerca Sant Pau (IR SANT PAU), 08041 Barcelona, Spain.; CIBER de Enfermedades Cardiovasculares, Instituto de Salud Carlos III, 28029 Madrid, Spain.; Instituto de Investigaciones Biomédicas de Barcelona-Consejo Superior de Investigaciones Científicas (IIBB-CSIC), 08036 Barcelona, Spain.
Rodríguez C; Institut de Recerca Sant Pau (IR SANT PAU), 08041 Barcelona, Spain.; CIBER de Enfermedades Cardiovasculares, Instituto de Salud Carlos III, 28029 Madrid, Spain.; Instituto de Investigaciones Biomédicas de Barcelona-Consejo Superior de Investigaciones Científicas (IIBB-CSIC), 08036 Barcelona, Spain.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Nov 30; Vol. 24 (23). Date of Electronic Publication: 2023 Nov 30.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Cyclic Nucleotide Phosphodiesterases, Type 4*/metabolism
Cardiovascular Diseases*/drug therapy
Humans ; Second Messenger Systems ; Cyclic AMP ; Myocytes, Cardiac/metabolism ; 3',5'-Cyclic-AMP Phosphodiesterases/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
HCN2 Channels in the Ventral Hippocampal CA1 Regulate Nociceptive Hypersensitivity in Mice.
Autorzy:
Zheng Y; Neuroscience Research Institute and Department of Neurobiology, School of Basic Medical Sciences, Peking University, Beijing 100191, China.
Shao S; Neuroscience Research Institute and Department of Neurobiology, School of Basic Medical Sciences, Peking University, Beijing 100191, China.
Zhang Y; National Health Commission Key Laboratory of Human Disease Comparative Medicine, Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases, Institute of Laboratory Animal Science, Chinese Academy of Medical Science (CAMS) & Peking Union Medical College (PUMC), Beijing 100101, China.
Yuan S; Neuroscience Research Institute and Department of Neurobiology, School of Basic Medical Sciences, Peking University, Beijing 100191, China.
Xing Y; Neuroscience Research Institute and Department of Neurobiology, School of Basic Medical Sciences, Peking University, Beijing 100191, China.
Wang J; Neuroscience Research Institute and Department of Neurobiology, School of Basic Medical Sciences, Peking University, Beijing 100191, China.
Qi X; Neuroscience Research Institute and Department of Neurobiology, School of Basic Medical Sciences, Peking University, Beijing 100191, China.
Cui K; Neuroscience Research Institute and Department of Neurobiology, School of Basic Medical Sciences, Peking University, Beijing 100191, China.
Tong J; Neuroscience Research Institute and Department of Neurobiology, School of Basic Medical Sciences, Peking University, Beijing 100191, China.
Liu F; Neuroscience Research Institute and Department of Neurobiology, School of Basic Medical Sciences, Peking University, Beijing 100191, China.
Cui S; Neuroscience Research Institute and Department of Neurobiology, School of Basic Medical Sciences, Peking University, Beijing 100191, China.
Wan Y; Neuroscience Research Institute and Department of Neurobiology, School of Basic Medical Sciences, Peking University, Beijing 100191, China.; Key Laboratory for Neuroscience, Ministry of Education/National Health Commission, Peking University, Beijing 100101, China.
Yi M; Neuroscience Research Institute and Department of Neurobiology, School of Basic Medical Sciences, Peking University, Beijing 100191, China.; Key Laboratory for Neuroscience, Ministry of Education/National Health Commission, Peking University, Beijing 100101, China.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Sep 07; Vol. 24 (18). Date of Electronic Publication: 2023 Sep 07.
Typ publikacji:
Journal Article
MeSH Terms:
Chronic Pain*
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels*/genetics
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels*/metabolism
Potassium Channels*/genetics
Potassium Channels*/metabolism
Animals ; Mice ; Action Potentials ; Cyclic Nucleotide-Gated Cation Channels/metabolism ; Nociception ; CA1 Region, Hippocampal/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The Dysfunction of Ca Channels in Hereditary and Chronic Human Heart Diseases and Experimental Animal Models.
Autorzy:
Shemarova I; I.M. Sechenov Institute of Evolutionary Physiology and Biochemistry of the Russian Academy of Sciences, 194223 Saint-Petersburg, Russia.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Oct 27; Vol. 24 (21). Date of Electronic Publication: 2023 Oct 27.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels*
Heart Failure*
Animals ; Humans ; Arrhythmias, Cardiac/genetics ; Models, Animal ; Calcium Channels/genetics ; Cyclic Nucleotide-Gated Cation Channels/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Xenon's Sedative Effect Is Mediated by Interaction with the Cyclic Nucleotide-Binding Domain (CNBD) of HCN2 Channels Expressed by Thalamocortical Neurons of the Ventrobasal Nucleus in Mice.
Autorzy:
Kassab NED; Department of Anesthesiology and Intensive Care Medicine, Klinikum Rechts der Isar, School of Medicine, Technical University of Munich, 81675 Munich, Germany.
Mehlfeld V; Department of Pharmacy-Center for Drug Research, Ludwig-Maximilians-Universitñt Mnchen, 81377 Munich, Germany.
Kass J; Department of Pharmacy-Center for Drug Research, Ludwig-Maximilians-Universitñt Mnchen, 81377 Munich, Germany.
Biel M; Department of Pharmacy-Center for Drug Research, Ludwig-Maximilians-Universitñt Mnchen, 81377 Munich, Germany.
Schneider G; Department of Anesthesiology and Intensive Care Medicine, Klinikum Rechts der Isar, School of Medicine, Technical University of Munich, 81675 Munich, Germany.
Rammes G; Department of Anesthesiology and Intensive Care Medicine, Klinikum Rechts der Isar, School of Medicine, Technical University of Munich, 81675 Munich, Germany.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 May 11; Vol. 24 (10). Date of Electronic Publication: 2023 May 11.
Typ publikacji:
Journal Article
MeSH Terms:
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels*/metabolism
Potassium Channels*/metabolism
Xenon*/pharmacology
Animals ; Mice ; Cyclic Nucleotide-Gated Cation Channels/metabolism ; Hypnotics and Sedatives/pharmacology ; Neurons/metabolism ; Nucleotides, Cyclic/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
CRISPR/Cas9 Knock-Out in Primary Neonatal and Adult Cardiomyocytes Reveals Distinct cAMP Dynamics Regulation by Various PDE2A and PDE3A Isoforms.
Autorzy:
Skryabin EB; Institute of Experimental Cardiovascular Research, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
De Jong KA; Institute of Experimental Cardiovascular Research, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.; German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, 20246 Hamburg, Germany.
Subramanian H; Institute of Experimental Cardiovascular Research, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.; German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, 20246 Hamburg, Germany.
Bork NI; Institute of Experimental Cardiovascular Research, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.; German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, 20246 Hamburg, Germany.
Froese A; Institute of Experimental Cardiovascular Research, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.; German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, 20246 Hamburg, Germany.
Skryabin BV; Core Facility Transgenic Animal and Genetic Engineering Models (TRAM), University of Münster, 48149 Münster, Germany.
Nikolaev VO; Institute of Experimental Cardiovascular Research, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.; German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, 20246 Hamburg, Germany.
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Źródło:
Cells [Cells] 2023 Jun 04; Vol. 12 (11). Date of Electronic Publication: 2023 Jun 04.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
CRISPR-Cas Systems*/genetics
Myocytes, Cardiac*/metabolism
Cyclic Nucleotide Phosphodiesterases, Type 2*/metabolism
Cyclic Nucleotide Phosphodiesterases, Type 3*/metabolism
Animals ; Mice ; Rats ; Cyclic AMP/metabolism ; Diethylstilbestrol ; Protein Isoforms/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Genome-wide identification and expression analysis of the cyclic nucleotide-gated ion channel (CNGC) gene family in Saccharum spontaneum.
Autorzy:
Zhang N; Guangdong Sugarcane Genetic Improvement Engineering Center, Institute of Nanfan & Seed Industry, Guangdong Academy of Sciences, Guangzhou, 510316, China.
Lin H; Guangdong Sugarcane Genetic Improvement Engineering Center, Institute of Nanfan & Seed Industry, Guangdong Academy of Sciences, Guangzhou, 510316, China.; Zhongkai University of Agriculture and Engineering, Guangzhou, 510225, China.
Zeng Q; Guangdong Sugarcane Genetic Improvement Engineering Center, Institute of Nanfan & Seed Industry, Guangdong Academy of Sciences, Guangzhou, 510316, China.
Fu D; Guangdong Sugarcane Genetic Improvement Engineering Center, Institute of Nanfan & Seed Industry, Guangdong Academy of Sciences, Guangzhou, 510316, China.
Gao X; Guangdong Sugarcane Genetic Improvement Engineering Center, Institute of Nanfan & Seed Industry, Guangdong Academy of Sciences, Guangzhou, 510316, China.
Wu J; Guangdong Sugarcane Genetic Improvement Engineering Center, Institute of Nanfan & Seed Industry, Guangdong Academy of Sciences, Guangzhou, 510316, China.
Feng X; Rice Research Institute, Guangdong Academy of Agricultural Sciences, Guangzhou, 510640, China.
Wang Q; Guangdong Sugarcane Genetic Improvement Engineering Center, Institute of Nanfan & Seed Industry, Guangdong Academy of Sciences, Guangzhou, 510316, China.
Ling Q; Guangdong Sugarcane Genetic Improvement Engineering Center, Institute of Nanfan & Seed Industry, Guangdong Academy of Sciences, Guangzhou, 510316, China. .
Wu Z; Guangdong Sugarcane Genetic Improvement Engineering Center, Institute of Nanfan & Seed Industry, Guangdong Academy of Sciences, Guangzhou, 510316, China. .
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Źródło:
BMC genomics [BMC Genomics] 2023 May 25; Vol. 24 (1), pp. 281. Date of Electronic Publication: 2023 May 25.
Typ publikacji:
Journal Article
MeSH Terms:
Cyclic Nucleotide-Gated Cation Channels*/genetics
Cyclic Nucleotide-Gated Cation Channels*/metabolism
Saccharum*/genetics
Saccharum*/metabolism
Plant Proteins/metabolism ; Phylogeny ; Nucleotides, Cyclic/metabolism ; Gene Expression Regulation, Plant
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Potential and limitations of PKA/ PKG inhibitors for platelet studies.
Autorzy:
Shpakova V; Laboratory of cellular mechanisms of blood homeostasis, Sechenov Institute of Evolutionary Physiology and Biochemistry of the Russian Academy of Sciences, Saint Petersburg, Russia.
Rukoyatkina N; Laboratory of cellular mechanisms of blood homeostasis, Sechenov Institute of Evolutionary Physiology and Biochemistry of the Russian Academy of Sciences, Saint Petersburg, Russia.
Walter U; Center for Thrombosis and Hemostasis (CTH), University Medical Center Mainz of the Johannes Gutenberg University Mainz, Mainz, Germany.
Gambaryan S; Laboratory of cellular mechanisms of blood homeostasis, Sechenov Institute of Evolutionary Physiology and Biochemistry of the Russian Academy of Sciences, Saint Petersburg, Russia.
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Źródło:
Platelets [Platelets] 2022 Aug 18; Vol. 33 (6), pp. 859-868. Date of Electronic Publication: 2021 Nov 30.
Typ publikacji:
Journal Article
MeSH Terms:
Cyclic AMP*/metabolism
Cyclic GMP-Dependent Protein Kinases*/metabolism
Blood Platelets/metabolism ; Cyclic AMP-Dependent Protein Kinases ; Cyclic GMP/metabolism ; Cyclic GMP/pharmacology ; Humans ; Intracellular Signaling Peptides and Proteins
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Retinal Cyclic Nucleotide-Gated Channel Regulation by Calmodulin.
Autorzy:
Bej A; Department of Chemistry, University of California, Davis, CA 95616, USA.
Ames JB; Department of Chemistry, University of California, Davis, CA 95616, USA.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Nov 16; Vol. 23 (22). Date of Electronic Publication: 2022 Nov 16.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Calmodulin*/genetics
Calmodulin*/metabolism
Cyclic Nucleotide-Gated Cation Channels*/genetics
Cyclic Nucleotide-Gated Cation Channels*/metabolism
Retina/metabolism ; Retinal Cone Photoreceptor Cells/metabolism ; Nucleotides, Cyclic
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Exploration of the Binding Mechanism of Cyclic Dinucleotide Analogs to Stimulating Factor Proteins and the Implications for Subsequent Analog Drug Design.
Autorzy:
Yuan SW; Henan Provincial Engineering Laboratory of Insect Bio-Reactor and College of Life Science and Agricultural Engineering, Nanyang Normal University, 1638 Wolong Road, Nanyang 473061, China.; Henan Key Laboratory of Organic Functional Molecule and Drug Innovation, School of Chemistry and Chemical Engineering, Henan Normal University, 46 Jianshe East Road, Xinxiang 453007, China.
Shi HL; Henan Provincial Engineering Laboratory of Insect Bio-Reactor and College of Life Science and Agricultural Engineering, Nanyang Normal University, 1638 Wolong Road, Nanyang 473061, China.; School of Bioengineering, Dalian University of Technology, 2 Linggong Road, Dalian 116024, China.
Fu MR; Henan Provincial Engineering Laboratory of Insect Bio-Reactor and College of Life Science and Agricultural Engineering, Nanyang Normal University, 1638 Wolong Road, Nanyang 473061, China.
Zhang XC; Henan Provincial Engineering Laboratory of Insect Bio-Reactor and College of Life Science and Agricultural Engineering, Nanyang Normal University, 1638 Wolong Road, Nanyang 473061, China.
Xi XQ; Henan Provincial Engineering Laboratory of Insect Bio-Reactor and College of Life Science and Agricultural Engineering, Nanyang Normal University, 1638 Wolong Road, Nanyang 473061, China.
Wang Y; Henan Provincial Engineering Laboratory of Insect Bio-Reactor and College of Life Science and Agricultural Engineering, Nanyang Normal University, 1638 Wolong Road, Nanyang 473061, China.
Shen TS; Henan Provincial Engineering Laboratory of Insect Bio-Reactor and College of Life Science and Agricultural Engineering, Nanyang Normal University, 1638 Wolong Road, Nanyang 473061, China.
Ma JL; Henan Key Laboratory of Organic Functional Molecule and Drug Innovation, School of Chemistry and Chemical Engineering, Henan Normal University, 46 Jianshe East Road, Xinxiang 453007, China.
Tang CD; Henan Provincial Engineering Laboratory of Insect Bio-Reactor and College of Life Science and Agricultural Engineering, Nanyang Normal University, 1638 Wolong Road, Nanyang 473061, China.
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Źródło:
Biomolecules [Biomolecules] 2024 Mar 14; Vol. 14 (3). Date of Electronic Publication: 2024 Mar 14.
Typ publikacji:
Journal Article
MeSH Terms:
Nucleotides, Cyclic*
Membrane Proteins*/metabolism
Humans ; Second Messenger Systems ; Interferons ; Signal Transduction ; Adjuvants, Immunologic
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Enhanced Tumor Targeting and Antitumor Activity of Methylated β-Cyclodextrin-Threaded Polyrotaxanes by Conjugating Cyclic RGD Peptides.
Autorzy:
Zhang S; Department of Organic Biomaterials, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University (TMDU), 2-3-10 Kanda-Surugadai, Chiyoda, Tokyo 101-0062, Japan.
Tamura A; Department of Organic Biomaterials, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University (TMDU), 2-3-10 Kanda-Surugadai, Chiyoda, Tokyo 101-0062, Japan.
Yui N; Department of Organic Biomaterials, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University (TMDU), 2-3-10 Kanda-Surugadai, Chiyoda, Tokyo 101-0062, Japan.
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Źródło:
Biomolecules [Biomolecules] 2024 Feb 15; Vol. 14 (2). Date of Electronic Publication: 2024 Feb 15.
Typ publikacji:
Journal Article
MeSH Terms:
Rotaxanes*/pharmacology
Rotaxanes*/chemistry
Rotaxanes*/metabolism
beta-Cyclodextrins*/chemistry
Neoplasms*/drug therapy
Peptides, Cyclic*
Humans ; Oligopeptides/chemistry ; Integrins
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Structural Characterization of Murine Phosphodiesterase 5 Isoforms and Involvement of Cysteine Residues in Supramolecular Assembly.
Autorzy:
Giorgi M; Department of Biology and Biotechnology 'C. Darwin', Sapienza University of Rome, Piazzale A. Moro 5, 00185 Rome, Italy.
Miele AE; Department of Biochemical Sciences, Sapienza University of Rome, Piazzale A. Moro 5, 00185 Rome, Italy.; UMR 5280 ISA-CNRS-UCBL, Université de Lyon, 5 Rue de La Doua, 69100 Villeurbanne, France.
Cardarelli S; Department of Biology and Biotechnology 'C. Darwin', Sapienza University of Rome, Piazzale A. Moro 5, 00185 Rome, Italy.
Giorgi A; Department of Biochemical Sciences, Sapienza University of Rome, Piazzale A. Moro 5, 00185 Rome, Italy.
Massimi M; Department of Life, Health and Environmental Sciences, University of L'Aquila, Via Vetoio, 67100 L'Aquila, Italy.
Biagioni S; Department of Biology and Biotechnology 'C. Darwin', Sapienza University of Rome, Piazzale A. Moro 5, 00185 Rome, Italy.
Saliola M; Department of Biology and Biotechnology 'C. Darwin', Sapienza University of Rome, Piazzale A. Moro 5, 00185 Rome, Italy.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Jan 06; Vol. 24 (2). Date of Electronic Publication: 2023 Jan 06.
Typ publikacji:
Journal Article
MeSH Terms:
Cysteine*
Cyclic GMP*/metabolism
Mice ; Animals ; Cyclic Nucleotide Phosphodiesterases, Type 5/metabolism ; Scattering, Small Angle ; X-Ray Diffraction ; Protein Isoforms ; Mammals/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Vascular and Liver Homeostasis in Juvenile Mice Require Endothelial Cyclic AMP-Dependent Protein Kinase A.
Autorzy:
Nedvetsky PI; VIB-KU Leuven Center for Cancer Biology, VIB, 3000 Leuven, Belgium.; Department of Oncology, KU Leuven, 3000 Leuven, Belgium.; Medical Cell Biology, Medical Clinic D, University Hospital Münster, 48149 Münster, Germany.
Cornelissen I; VIB-KU Leuven Center for Cancer Biology, VIB, 3000 Leuven, Belgium.; Department of Oncology, KU Leuven, 3000 Leuven, Belgium.
Mathivet T; VIB-KU Leuven Center for Cancer Biology, VIB, 3000 Leuven, Belgium.; Department of Oncology, KU Leuven, 3000 Leuven, Belgium.; Bordeaux Institute of Oncology, BRIC U1312, INSERM, Université de Bordeaux, 33000 Bordeaux, France.
Bouleti C; VIB-KU Leuven Center for Cancer Biology, VIB, 3000 Leuven, Belgium.; Department of Oncology, KU Leuven, 3000 Leuven, Belgium.; Cardiology Department, Assistance Publique-Hôpitaux de Paris, Bichat Hospital, 75018 Paris, France.
Ou P; Department of Radiology, Assistance Publique-Hôpitaux de Paris, Bichat Hospital, 75018 Paris, France.
Baatsen P; VIB-KU Leuven Center for Brain and Disease Research, EM-Platform at the VIB Bio Imaging Core, 3000 Leuven, Belgium.
Zhao X; VIB-KU Leuven Center for Cancer Biology, VIB, 3000 Leuven, Belgium.; Department of Oncology, KU Leuven, 3000 Leuven, Belgium.
Schuit F; Gene Expression Unit, KU Leuven, 3000 Leuven, Belgium.
Stanchi F; VIB-KU Leuven Center for Cancer Biology, VIB, 3000 Leuven, Belgium.; Department of Oncology, KU Leuven, 3000 Leuven, Belgium.
Mostov KE; Department of Anatomy, University of California San Francisco, San Francisco, CA 94158, USA.
Gerhardt H; VIB-KU Leuven Center for Cancer Biology, VIB, 3000 Leuven, Belgium.; Department of Oncology, KU Leuven, 3000 Leuven, Belgium.; Max-Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), 13125 Berlin, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site Berlin, 10785 Berlin, Germany.; Berlin Institute of Health (BIH), 10178 Berlin, Germany.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Sep 27; Vol. 23 (19). Date of Electronic Publication: 2022 Sep 27.
Typ publikacji:
Journal Article
MeSH Terms:
Blood Vessels*/metabolism
Blood Vessels*/physiology
Cyclic AMP-Dependent Protein Kinase Catalytic Subunits*/metabolism
Cyclic AMP-Dependent Protein Kinase Catalytic Subunits*/physiology
Endothelial Cells*/metabolism
Endothelial Cells*/physiology
Liver*/metabolism
Liver*/physiology
Albumins ; Animals ; Cyclic AMP ; Cyclic AMP-Dependent Protein Kinases/metabolism ; Cyclic AMP-Dependent Protein Kinases/physiology ; Homeostasis ; Hypoalbuminemia ; Hypoglycemia ; Mice ; Recombinases
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Selective inhibition of phosphodiesterase 4D increases tau phosphorylation at Ser214 residue.
Autorzy:
Villa V; Department of Experimental Medicine, Section of General Pathology, School of Medical and Pharmaceutical Sciences, University of Genoa, Genoa, Italy.
Montalto G; Department of Experimental Medicine, Section of General Pathology, School of Medical and Pharmaceutical Sciences, University of Genoa, Genoa, Italy.
Caudano F; Department of Experimental Medicine, Section of General Pathology, School of Medical and Pharmaceutical Sciences, University of Genoa, Genoa, Italy.
Fedele E; Department of Pharmacy, Section of Pharmacology and Toxicology, School of Medical and Pharmaceutical Sciences, University of Genoa, Genoa, Italy.; IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Ricciarelli R; Department of Experimental Medicine, Section of General Pathology, School of Medical and Pharmaceutical Sciences, University of Genoa, Genoa, Italy.; IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
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Źródło:
BioFactors (Oxford, England) [Biofactors] 2022 Sep; Vol. 48 (5), pp. 1111-1117. Date of Electronic Publication: 2022 May 13.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*/drug therapy
Alzheimer Disease*/metabolism
Cyclic Nucleotide Phosphodiesterases, Type 4*/genetics
Cyclic Nucleotide Phosphodiesterases, Type 4*/metabolism
Cyclic Nucleotide Phosphodiesterases, Type 4*/therapeutic use
Adenylyl Cyclases/metabolism ; Animals ; Cyclic AMP-Dependent Protein Kinases/metabolism ; Cyclic AMP-Dependent Protein Kinases/therapeutic use ; Phosphorylation ; Rats
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Elevated retinal cGMP is not associated with elevated circulating cGMP levels in a canine model of retinitis pigmentosa.
Autorzy:
Occelli LM; Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan, United States of America.
Sun K; Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan, United States of America.
Winkler PA; Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan, United States of America.
Morgan BJ; Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan, United States of America.
Petersen-Jones SM; Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan, United States of America.
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Źródło:
PloS one [PLoS One] 2022 Dec 30; Vol. 17 (12), pp. e0279437. Date of Electronic Publication: 2022 Dec 30 (Print Publication: 2022).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Cyclic Nucleotide Phosphodiesterases, Type 6*/genetics
Retinitis Pigmentosa*
Dogs ; Animals ; Retina ; Cyclic GMP ; Heterozygote
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Sedative Properties of Dexmedetomidine Are Mediated Independently from Native Thalamic Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel Function at Clinically Relevant Concentrations.
Autorzy:
Schwerin S; Department of Anesthesiology and Intensive Care Medicine, Klinikum Rechts der Isar, Technical University of Munich School of Medicine, 81675 Munich, Germany.
Westphal C; Department of Anesthesiology and Intensive Care Medicine, Klinikum Rechts der Isar, Technical University of Munich School of Medicine, 81675 Munich, Germany.
Klug C; Department of Anesthesiology and Intensive Care Medicine, Klinikum Rechts der Isar, Technical University of Munich School of Medicine, 81675 Munich, Germany.
Schneider G; Department of Anesthesiology and Intensive Care Medicine, Klinikum Rechts der Isar, Technical University of Munich School of Medicine, 81675 Munich, Germany.
Kreuzer M; Department of Anesthesiology and Intensive Care Medicine, Klinikum Rechts der Isar, Technical University of Munich School of Medicine, 81675 Munich, Germany.
Haseneder R; Department of Anesthesiology and Intensive Care Medicine, Klinikum Rechts der Isar, Technical University of Munich School of Medicine, 81675 Munich, Germany.
Kratzer S; Department of Anesthesiology and Intensive Care Medicine, Klinikum Rechts der Isar, Technical University of Munich School of Medicine, 81675 Munich, Germany.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Dec 28; Vol. 24 (1). Date of Electronic Publication: 2022 Dec 28.
Typ publikacji:
Journal Article
MeSH Terms:
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels*/metabolism
Dexmedetomidine*/pharmacology
Mice ; Animals ; Cyclic Nucleotide-Gated Cation Channels/metabolism ; Hypnotics and Sedatives/pharmacology ; Thalamus/metabolism ; Adrenergic alpha-2 Receptor Agonists/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
cAMP-Dependent Signaling and Ovarian Cancer.
Autorzy:
Kilanowska A; Department of Anatomy and Histology, Collegium Medicum, University of Zielona Gora, 65-046 Zielona Gora, Poland.
Ziółkowska A; Department of Anatomy and Histology, Collegium Medicum, University of Zielona Gora, 65-046 Zielona Gora, Poland.
Stasiak P; Department of Anatomy and Histology, Collegium Medicum, University of Zielona Gora, 65-046 Zielona Gora, Poland.
Gibas-Dorna M; Department of Anatomy and Histology, Collegium Medicum, University of Zielona Gora, 65-046 Zielona Gora, Poland.
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Źródło:
Cells [Cells] 2022 Nov 29; Vol. 11 (23). Date of Electronic Publication: 2022 Nov 29.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Cyclic AMP-Dependent Protein Kinases*/metabolism
Ovarian Neoplasms*
Humans ; Female ; Signal Transduction ; Cyclic AMP Response Element-Binding Protein/metabolism ; Phosphorylation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Protein kinase A participates in hyphal and appressorial development by targeting Efg1-mediated transcription of a Rab GTPase in Setosphaeria turcica.
Autorzy:
Liu Y; State Key Laboratory of North China Crop Improvement and Regulation, Baoding, China.; College of Life Sciences, Hebei Agricultural University, Baoding, China.; Key Laboratory of Hebei Province for Plant Physiology and Molecular Pathology, Baoding, China.
Shen S; State Key Laboratory of North China Crop Improvement and Regulation, Baoding, China.; College of Life Sciences, Hebei Agricultural University, Baoding, China.; Key Laboratory of Hebei Province for Plant Physiology and Molecular Pathology, Baoding, China.
Hao Z; State Key Laboratory of North China Crop Improvement and Regulation, Baoding, China.; College of Life Sciences, Hebei Agricultural University, Baoding, China.; Key Laboratory of Hebei Province for Plant Physiology and Molecular Pathology, Baoding, China.
Wang Q; College of Life Sciences, Hebei Agricultural University, Baoding, China.; Key Laboratory of Hebei Province for Plant Physiology and Molecular Pathology, Baoding, China.
Zhang Y; College of Life Sciences, Hebei Agricultural University, Baoding, China.; Key Laboratory of Hebei Province for Plant Physiology and Molecular Pathology, Baoding, China.
Zhao Y; College of Life Sciences, Hebei Agricultural University, Baoding, China.; Key Laboratory of Hebei Province for Plant Physiology and Molecular Pathology, Baoding, China.
Tong Y; State Key Laboratory of North China Crop Improvement and Regulation, Baoding, China.; College of Life Sciences, Hebei Agricultural University, Baoding, China.; Key Laboratory of Hebei Province for Plant Physiology and Molecular Pathology, Baoding, China.
Zeng F; State Key Laboratory of North China Crop Improvement and Regulation, Baoding, China.; College of Life Sciences, Hebei Agricultural University, Baoding, China.; Key Laboratory of Hebei Province for Plant Physiology and Molecular Pathology, Baoding, China.
Dong J; State Key Laboratory of North China Crop Improvement and Regulation, Baoding, China.; Key Laboratory of Hebei Province for Plant Physiology and Molecular Pathology, Baoding, China.; College of Plant Protection, Hebei Agricultural University, Baoding, China.
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Źródło:
Molecular plant pathology [Mol Plant Pathol] 2022 Nov; Vol. 23 (11), pp. 1608-1619. Date of Electronic Publication: 2022 Aug 05.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cyclic AMP-Dependent Protein Kinases*/genetics
Hyphae*
Adenosine Monophosphate ; Ascomycota ; Chitin/metabolism ; Cyclic AMP/metabolism ; Fungal Proteins/metabolism ; Gene Expression Regulation, Fungal ; Transcription Factors/metabolism ; rab GTP-Binding Proteins/genetics ; rab GTP-Binding Proteins/metabolism
SCR Organism:
Exserohilum turcicum
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Wyświetlanie 1-20 z 216540

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