Temat: "dclk1" - OpacWWW - Prolib Integro

Skocz do pozycji: 1.

Tytuł:: Epigenetic Landscape and Therapeutic Implication of Gene Isoforms of Doublecortin-Like Kinase 1 for Cancer Stem Cells.
Autorzy:: Moore LL; Department of Medicine, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
Houchen CW; Department of Medicine, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.; Department of Veterans Affairs Medical Center, Oklahoma City, OK 73104, USA.; The Peggy and Charles Stephenson Cancer Center, Oklahoma City, OK 73104, USA.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2023 Nov 16; Vol. 24 (22). Date of Electronic Publication: 2023 Nov 16.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Doublecortin-Like Kinases*
Neoplasms*/genetics
Neoplasms*/therapy
Neoplasms*/metabolism
Humans ; Epigenesis, Genetic ; Intracellular Signaling Peptides and Proteins/metabolism ; Protein Serine-Threonine Kinases/genetics ; Protein Serine-Threonine Kinases/metabolism ; Protein Isoforms/metabolism ; Neoplastic Stem Cells/metabolism

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Skocz do pozycji: 2.

Tytuł:: Molecular Mechanism of Mutational Disruption of DCLK1 Autoinhibition Provides a Rationale for Inhibitor Screening.
Autorzy:: Chen W; State Key Laboratory of Microbial Metabolism & Joint International Research Laboratory of Metabolic and Developmental Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China.
Liu R; Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China.
Yu Y; Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China.
Wei D; State Key Laboratory of Microbial Metabolism & Joint International Research Laboratory of Metabolic and Developmental Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China.
Chen Q; Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China.
Xu Q; State Key Laboratory of Microbial Metabolism & Joint International Research Laboratory of Metabolic and Developmental Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2023 Sep 13; Vol. 24 (18). Date of Electronic Publication: 2023 Sep 13.
Typ publikacji:: Journal Article
MeSH Terms:: Doublecortin-Like Kinases*
Intracellular Signaling Peptides and Proteins*/genetics
Humans ; Protein Serine-Threonine Kinases/metabolism ; Carcinogenesis ; Mutation

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Skocz do pozycji: 3.

Tytuł:: [Doublecortin-like kinase 1 activates Hippo pathway to promote migration, invasion and proliferation of pancreatic cancer cells].
Autorzy:: Yan R; Department of Oncology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China.
Liang ZW; Department of Oncology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China.
Liu HS; Department of Oncology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China.
Ge Y; Department of Oncology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China.
An GY; Department of Oncology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China.; Pokaż więcej
Źródło:: Zhonghua zhong liu za zhi [Chinese journal of oncology] [Zhonghua Zhong Liu Za Zhi] 2023 Jul 23; Vol. 45 (7), pp. 594-604.
Typ publikacji:: English Abstract; Journal Article
MeSH Terms:: Doublecortin-Like Kinases*
Pancreatic Neoplasms*/pathology
Humans ; Hippo Signaling Pathway ; Verteporfin/pharmacology ; Cell Line, Tumor ; Protein Serine-Threonine Kinases/genetics ; Protein Serine-Threonine Kinases/metabolism ; YAP-Signaling Proteins ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Cell Proliferation/genetics ; Gene Expression Regulation, Neoplastic ; Tumor Suppressor Proteins/genetics ; Pancreatic Neoplasms

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Skocz do pozycji: 4.

Tytuł:: Alveolar-Capillary Barrier Protection In Vitro: Lung Cell Type-Specific Effects and Molecular Mechanisms Induced by 1α, 25-Dihydroxyvitamin D3.
Autorzy:: Xiong J; Experimental Trauma Surgery, Department of Trauma Surgery and Orthopedics, University Medical Center Schleswig-Holstein, Campus Kiel, 24105 Kiel, Germany.
Kaleja P; Systematic Proteomics & Bioanalytics, Institute for Experimental Medicine, Christian-Albrechts-Universität zu Kiel, 24015 Kiel, Germany.
Ückert L; Experimental Trauma Surgery, Department of Trauma Surgery and Orthopedics, University Medical Center Schleswig-Holstein, Campus Kiel, 24105 Kiel, Germany.
Nezaratizadeh N; Experimental Trauma Surgery, Department of Trauma Surgery and Orthopedics, University Medical Center Schleswig-Holstein, Campus Kiel, 24105 Kiel, Germany.
Krantz S; Experimental Trauma Surgery, Department of Trauma Surgery and Orthopedics, University Medical Center Schleswig-Holstein, Campus Kiel, 24105 Kiel, Germany.
Krause MF; Department of Pediatrics, University Medical Center Schleswig-Holstein, Campus Kiel, 24105 Kiel, Germany.
Fitschen-Oestern S; Experimental Trauma Surgery, Department of Trauma Surgery and Orthopedics, University Medical Center Schleswig-Holstein, Campus Kiel, 24105 Kiel, Germany.
Seekamp A; Experimental Trauma Surgery, Department of Trauma Surgery and Orthopedics, University Medical Center Schleswig-Holstein, Campus Kiel, 24105 Kiel, Germany.
Cassidy L; Systematic Proteomics & Bioanalytics, Institute for Experimental Medicine, Christian-Albrechts-Universität zu Kiel, 24015 Kiel, Germany.
Tholey A; Systematic Proteomics & Bioanalytics, Institute for Experimental Medicine, Christian-Albrechts-Universität zu Kiel, 24015 Kiel, Germany.
Fuchs S; Experimental Trauma Surgery, Department of Trauma Surgery and Orthopedics, University Medical Center Schleswig-Holstein, Campus Kiel, 24105 Kiel, Germany.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2023 Apr 14; Vol. 24 (8). Date of Electronic Publication: 2023 Apr 14.
Typ publikacji:: Journal Article
MeSH Terms:: Endothelial Cells*
Interleukin-6*
Humans ; Lipopolysaccharides/pharmacology ; Pulmonary Surfactant-Associated Proteins ; Alveolar Epithelial Cells ; Surface-Active Agents ; Doublecortin-Like Kinases

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Skocz do pozycji: 5.

Tytuł:: Thrombin induces IL-8/CXCL8 expression by DCLK1-dependent RhoA and YAP activation in human lung epithelial cells.
Autorzy:: Yuliani FS; International Graduate Program in Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; Department of Pharmacology and Therapy, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia.
Chen JY; Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Cheng WH; School of Respiratory Therapy College of Medicine, Taipei Medical University, Taipei, Taiwan.; Respiratory Therapy, Division of Pulmonary Medicine, Department of Internal Medicine, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.
Wen HC; School of Respiratory Therapy College of Medicine, Taipei Medical University, Taipei, Taiwan.
Chen BC; Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan. .; School of Respiratory Therapy College of Medicine, Taipei Medical University, Taipei, Taiwan. .; Respiratory Therapy, Division of Pulmonary Medicine, Department of Internal Medicine, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan. .
Lin CH; Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan. .; Pokaż więcej
Źródło:: Journal of biomedical science [J Biomed Sci] 2022 Nov 11; Vol. 29 (1), pp. 95. Date of Electronic Publication: 2022 Nov 11.
Typ publikacji:: Journal Article
MeSH Terms:: Interleukin-8*/genetics
Asthma*/chemically induced
Asthma*/genetics
Mice ; Animals ; Humans ; Thrombin/pharmacology ; Thrombin/metabolism ; NF-kappa B/metabolism ; RNA, Small Interfering/metabolism ; Ovalbumin/metabolism ; Doublecortin-Like Kinases ; Phosphorylation ; Lung/metabolism ; Epithelial Cells/metabolism ; Luciferases/metabolism ; rhoA GTP-Binding Protein/metabolism ; Protein Serine-Threonine Kinases/genetics

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Skocz do pozycji: 6.

Tytuł:: Targeting DCLK1 overcomes 5-fluorouracil resistance in colorectal cancer through inhibiting CCAR1/β-catenin pathway-mediated cancer stemness.
Autorzy:: Wang L; Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Zhao L; Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Lin Z; Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Yu D; Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Jin M; Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Zhou P; Wuhan YZY Medical Science & Technology Co., Ltd., Wuhan 430075, China.
Ren J; Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Cheng J; Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Yang K; Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Wu G; Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Zhang T; Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Zhang D; Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.; Pokaż więcej
Źródło:: Clinical and translational medicine [Clin Transl Med] 2022 May; Vol. 12 (5), pp. e743.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Colorectal Neoplasms*/drug therapy
Colorectal Neoplasms*/genetics
Colorectal Neoplasms*/metabolism
Doublecortin-Like Kinases*/genetics
Fluorouracil*/pharmacology
beta Catenin*/genetics
beta Catenin*/metabolism
Apoptosis Regulatory Proteins/therapeutic use ; Cell Cycle ; Cell Cycle Proteins/metabolism ; Cell Cycle Proteins/therapeutic use ; Cell Line, Tumor ; Humans ; Intracellular Signaling Peptides and Proteins/genetics ; Intracellular Signaling Peptides and Proteins/metabolism ; Neoplasm Recurrence, Local ; Protein Serine-Threonine Kinases/genetics ; Wnt Signaling Pathway

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Skocz do pozycji: 7.

Tytuł:: Inhibition of DCLK1 with DCLK1-IN-1 Suppresses Renal Cell Carcinoma Invasion and Stemness and Promotes Cytotoxic T-Cell-Mediated Anti-Tumor Immunity.
Autorzy:: Ding L; Department of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China.; Fujian Key Laboratory of Integrative Medicine in Geriatrics, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China.; Key Laboratory of Integrative Medicine, Fujian Province University, Fuzhou 350122, China.
Yang Y; Department of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China.; Fujian Key Laboratory of Integrative Medicine in Geriatrics, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China.; Key Laboratory of Integrative Medicine, Fujian Province University, Fuzhou 350122, China.
Ge Y; Department of Oncology, Capital Medical University, Beijing Chao-Yang Hospital, Beijing 100020, China.
Lu Q; Department of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China.; Fujian Key Laboratory of Integrative Medicine in Geriatrics, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China.; Key Laboratory of Integrative Medicine, Fujian Province University, Fuzhou 350122, China.
Yan Z; Affiliated Fuzhou Hospital of Traditional Chinese Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350001, China.
Chen X; Department of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China.; Fujian Key Laboratory of Integrative Medicine in Geriatrics, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China.; Key Laboratory of Integrative Medicine, Fujian Province University, Fuzhou 350122, China.
Du J; Department of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China.; Fujian Key Laboratory of Integrative Medicine in Geriatrics, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China.; Key Laboratory of Integrative Medicine, Fujian Province University, Fuzhou 350122, China.
Hafizi S; School of Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth PO1 2DT, UK.
Xu X; Department of General Surgery, The First People's Hospital of Taicang, Taicang Affiliated Hospital of Soochow University, Suzhou 215400, China.
Yao J; Department of Oncology, Capital Medical University, Beijing Chao-Yang Hospital, Beijing 100020, China.
Liu J; Department of Oncology, Capital Medical University, Beijing Chao-Yang Hospital, Beijing 100020, China.
Cao Z; Department of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China.; Fujian Key Laboratory of Integrative Medicine in Geriatrics, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China.; Key Laboratory of Integrative Medicine, Fujian Province University, Fuzhou 350122, China.
Weygant N; Department of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China.; Fujian Key Laboratory of Integrative Medicine in Geriatrics, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China.; Key Laboratory of Integrative Medicine, Fujian Province University, Fuzhou 350122, China.; Pokaż więcej
Źródło:: Cancers [Cancers (Basel)] 2021 Nov 16; Vol. 13 (22). Date of Electronic Publication: 2021 Nov 16.
Typ publikacji:: Journal Article

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Skocz do pozycji: 8.

Tytuł:: Structural Basis of Inhibition of DCLK1 by Ruxolitinib.
Autorzy:: Jang DM; Research Institute, National Cancer Center, Goyang 10408, Gyeonggi, Korea.
Lim HJ; Research Institute, National Cancer Center, Goyang 10408, Gyeonggi, Korea.
Hahn H; Research Institute, National Cancer Center, Goyang 10408, Gyeonggi, Korea.
Lee Y; Research Institute, National Cancer Center, Goyang 10408, Gyeonggi, Korea.
Kim HK; Research Institute, National Cancer Center, Goyang 10408, Gyeonggi, Korea.
Kim HS; Research Institute, National Cancer Center, Goyang 10408, Gyeonggi, Korea.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2021 Aug 06; Vol. 22 (16). Date of Electronic Publication: 2021 Aug 06.
Typ publikacji:: Journal Article
MeSH Terms:: Antineoplastic Agents/*pharmacology
Intracellular Signaling Peptides and Proteins/*antagonists & inhibitors
Protein Kinase Inhibitors/*pharmacology
Protein Serine-Threonine Kinases/*antagonists & inhibitors
Pyrazoles/*pharmacology
Antineoplastic Agents/chemistry ; Doublecortin-Like Kinases ; Humans ; Intracellular Signaling Peptides and Proteins/chemistry ; Intracellular Signaling Peptides and Proteins/metabolism ; Molecular Docking Simulation ; Nitriles ; Protein Conformation/drug effects ; Protein Kinase Inhibitors/chemistry ; Protein Serine-Threonine Kinases/chemistry ; Protein Serine-Threonine Kinases/metabolism ; Pyrazoles/chemistry ; Pyrimidines

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Skocz do pozycji: 9.

Tytuł:: Tuft and Cancer Stem Cell Marker DCLK1: A New Target to Enhance Anti-Tumor Immunity in the Tumor Microenvironment.
Autorzy:: Cao Z; Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China.; Fujian Key Laboratory of Integrative Medicine in Geriatrics, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China.; Key Laboratory of Integrative Medicine of Fujian Province University, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China.
Weygant N; Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China.; Fujian Key Laboratory of Integrative Medicine in Geriatrics, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China.; Key Laboratory of Integrative Medicine of Fujian Province University, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China.
Chandrakesan P; Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.; Peggy and Charles Stephenson Cancer Center, Oklahoma City, OK 73104, USA.; Department of Veterans Affairs Medical Center, Oklahoma City, OK 73104, USA.
Houchen CW; Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.; Peggy and Charles Stephenson Cancer Center, Oklahoma City, OK 73104, USA.; Department of Veterans Affairs Medical Center, Oklahoma City, OK 73104, USA.
Peng J; Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China.; Fujian Key Laboratory of Integrative Medicine in Geriatrics, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China.; Key Laboratory of Integrative Medicine of Fujian Province University, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China.
Qu D; Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.; Peggy and Charles Stephenson Cancer Center, Oklahoma City, OK 73104, USA.; Department of Veterans Affairs Medical Center, Oklahoma City, OK 73104, USA.; Pokaż więcej
Źródło:: Cancers [Cancers (Basel)] 2020 Dec 17; Vol. 12 (12). Date of Electronic Publication: 2020 Dec 17.
Typ publikacji:: Journal Article; Review

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Skocz do pozycji: 10.

Tytuł:: Saffron Crudes and Compounds Restrict MACC1-Dependent Cell Proliferation and Migration of Colorectal Cancer Cells.
Autorzy:: Güllü N; Experimental and Clinical Research Center, Charité-Universitätsmedizin Berlin, and Max-Delbrück-Center for Molecular Medicine, Robert-Rössle-Straße 10, 13125 Berlin, Germany.; German Cancer Consortium (DKTK), Heidelberg, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.
Kobelt D; Experimental and Clinical Research Center, Charité-Universitätsmedizin Berlin, and Max-Delbrück-Center for Molecular Medicine, Robert-Rössle-Straße 10, 13125 Berlin, Germany.; German Cancer Consortium (DKTK), Heidelberg, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.
Brim H; College of Medicine & Cancer Center, Howard University 2041 Georgia Av. NW, Washington, DC 20059, USA.
Rahman S; Experimental and Clinical Research Center, Charité-Universitätsmedizin Berlin, and Max-Delbrück-Center for Molecular Medicine, Robert-Rössle-Straße 10, 13125 Berlin, Germany.
Timm L; Experimental and Clinical Research Center, Charité-Universitätsmedizin Berlin, and Max-Delbrück-Center for Molecular Medicine, Robert-Rössle-Straße 10, 13125 Berlin, Germany.
Smith J; Experimental and Clinical Research Center, Charité-Universitätsmedizin Berlin, and Max-Delbrück-Center for Molecular Medicine, Robert-Rössle-Straße 10, 13125 Berlin, Germany.
Soleimani A; College of Medicine & Cancer Center, Howard University 2041 Georgia Av. NW, Washington, DC 20059, USA.
Di Marco S; Center for Synaptic Neuroscience and Technology, The Italian Institute of Technology, IRCCS Ospedale Policlinico San Martino, 16132 Genova, Italy.
Bisti S; NetS3 Laboratory Neuroscience and Brain Technologies (NBT), The Italian Institute of Technology (IIT), Via Morego 30, 16128 Genova, Italy.; Consorzio Interuniversitario INBB Istituto Nazionale Biostrutture e Biosistemi, V.le Medaglie D'Oro, 305, 00136 Roma, Italy.
Ashktorab H; College of Medicine & Cancer Center, Howard University 2041 Georgia Av. NW, Washington, DC 20059, USA.
Stein U; Experimental and Clinical Research Center, Charité-Universitätsmedizin Berlin, and Max-Delbrück-Center for Molecular Medicine, Robert-Rössle-Straße 10, 13125 Berlin, Germany.; German Cancer Consortium (DKTK), Heidelberg, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.; Pokaż więcej
Źródło:: Cells [Cells] 2020 Aug 03; Vol. 9 (8). Date of Electronic Publication: 2020 Aug 03.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Antineoplastic Agents/*pharmacology
Cell Movement/*drug effects
Cell Proliferation/*drug effects
Colorectal Neoplasms/*pathology
Crocus/*chemistry
Trans-Activators/*metabolism
Antineoplastic Agents/chemistry ; Carotenoids/analysis ; Carotenoids/pharmacology ; Cell Cycle Checkpoints/drug effects ; Cell Line, Tumor ; Cell Survival/drug effects ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/metabolism ; Doublecortin-Like Kinases ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Intracellular Signaling Peptides and Proteins/genetics ; Intracellular Signaling Peptides and Proteins/metabolism ; Plant Extracts/chemistry ; Plant Extracts/pharmacology ; Protein Serine-Threonine Kinases/genetics ; Protein Serine-Threonine Kinases/metabolism ; Trans-Activators/genetics

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Skocz do pozycji: 11.

Tytuł:: Cancer Stem Cell Marker DCLK1 Correlates with Tumorigenic Immune Infiltrates in the Colon and Gastric Adenocarcinoma Microenvironments.
Autorzy:: Wu X; Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.; Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350122, China.
Qu D; Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.; Department of Veterans Affairs Medical Center, Oklahoma City, OK 73104, USA.; Peggy and Charles Stephenson Cancer Center, Oklahoma City, OK 73104, USA.
Weygant N; Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350122, China.; Fujian Key Laboratory of Integrative Medicine in Geriatrics, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350122, China.
Peng J; Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350122, China.; Fujian Key Laboratory of Integrative Medicine in Geriatrics, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350122, China.
Houchen CW; Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.; Department of Veterans Affairs Medical Center, Oklahoma City, OK 73104, USA.; Peggy and Charles Stephenson Cancer Center, Oklahoma City, OK 73104, USA.; Pokaż więcej
Źródło:: Cancers [Cancers (Basel)] 2020 Jan 22; Vol. 12 (2). Date of Electronic Publication: 2020 Jan 22.
Typ publikacji:: Journal Article

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Skocz do pozycji: 12.

Tytuł:: DCLK1 Monoclonal Antibody-Based CAR-T Cells as a Novel Treatment Strategy against Human Colorectal Cancers.
Autorzy:: Sureban SM; COARE Holdings Inc., Oklahoma, OK 73104, USA.; Department of Internal Medicine, Digestive Diseases and Nutrition Section, The University of Oklahoma Health Science Center, Oklahoma, OK 73014, USA.
Berahovich R; ProMab Biotechnologies Inc., Richmond, CA 94806, USA.
Zhou H; ProMab Biotechnologies Inc., Richmond, CA 94806, USA.
Xu S; ProMab Biotechnologies Inc., Richmond, CA 94806, USA.
Wu L; ProMab Biotechnologies Inc., Richmond, CA 94806, USA.
Ding K; Department of Internal Medicine, Digestive Diseases and Nutrition Section, The University of Oklahoma Health Science Center, Oklahoma, OK 73014, USA.
May R; COARE Holdings Inc., Oklahoma, OK 73104, USA.; Department of Internal Medicine, Digestive Diseases and Nutrition Section, The University of Oklahoma Health Science Center, Oklahoma, OK 73014, USA.
Qu D; COARE Holdings Inc., Oklahoma, OK 73104, USA.; Department of Internal Medicine, Digestive Diseases and Nutrition Section, The University of Oklahoma Health Science Center, Oklahoma, OK 73014, USA.
Bannerman-Menson E; COARE Holdings Inc., Oklahoma, OK 73104, USA.
Golubovskaya V; ProMab Biotechnologies Inc., Richmond, CA 94806, USA.
Houchen CW; COARE Holdings Inc., Oklahoma, OK 73104, USA.; Department of Internal Medicine, Digestive Diseases and Nutrition Section, The University of Oklahoma Health Science Center, Oklahoma, OK 73014, USA.; Veterans Affairs Medical Center, Oklahoma, OK 73104, USA.; Pokaż więcej
Źródło:: Cancers [Cancers (Basel)] 2019 Dec 23; Vol. 12 (1). Date of Electronic Publication: 2019 Dec 23.
Typ publikacji:: Journal Article

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Skocz do pozycji: 13.

Tytuł:: Changes in Calcium Homeostasis and Gene Expression Implicated in Epilepsy in Hippocampi of Mice Overexpressing ORAI1 .
Autorzy:: Majewski L; Laboratory of Neurodegeneration, International Institute of Molecular and Cell Biology in Warsaw, Trojdena 4, 02-109 Warsaw, Poland.
Wojtas B; Laboratory of Molecular Neurobiology, Nencki Institute of Experimental Biology, PAS, Pasteura 3, 02-093 Warsaw, Poland.
Maciąg F; Laboratory of Neurodegeneration, International Institute of Molecular and Cell Biology in Warsaw, Trojdena 4, 02-109 Warsaw, Poland.
Kuznicki J; Laboratory of Neurodegeneration, International Institute of Molecular and Cell Biology in Warsaw, Trojdena 4, 02-109 Warsaw, Poland.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2019 Nov 06; Vol. 20 (22). Date of Electronic Publication: 2019 Nov 06.
Typ publikacji:: Journal Article
MeSH Terms:: Gene Expression Regulation*
Homeostasis*
Calcium/*metabolism
Epilepsy/*genetics
Hippocampus/*metabolism
ORAI1 Protein/*metabolism
Animals ; CA1 Region, Hippocampal/metabolism ; Female ; Humans ; Mice ; Neurogenesis/genetics ; Neurons/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Reproducibility of Results ; Ribonucleoproteins/metabolism ; Ribosomes/metabolism ; Up-Regulation/genetics

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Skocz do pozycji: 14.

Tytuł:: Expression of alternatively spliced variants of the Dclk1 gene is regulated by psychotropic drugs.
Autorzy:: Zygmunt M; Department of Molecular Neuropharmacology, Institute of Pharmacology of the Polish Academy of Sciences, Smetna 12, 31-343, Krakow, Poland.
Hoinkis D; Department of Molecular Neuropharmacology, Institute of Pharmacology of the Polish Academy of Sciences, Smetna 12, 31-343, Krakow, Poland.
Hajto J; Department of Molecular Neuropharmacology, Institute of Pharmacology of the Polish Academy of Sciences, Smetna 12, 31-343, Krakow, Poland.
Piechota M; Department of Molecular Neuropharmacology, Institute of Pharmacology of the Polish Academy of Sciences, Smetna 12, 31-343, Krakow, Poland.
Skupień-Rabian B; Laboratory of Proteomics and Mass Spectrometry, Malopolska Centre of Biotechnology, Jagiellonian University, Krakow, Poland.
Jankowska U; Laboratory of Proteomics and Mass Spectrometry, Malopolska Centre of Biotechnology, Jagiellonian University, Krakow, Poland.
Kędracka-Krok S; Department of Physical Biochemistry, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland.
Rodriguez Parkitna J; Department of Molecular Neuropharmacology, Institute of Pharmacology of the Polish Academy of Sciences, Smetna 12, 31-343, Krakow, Poland.
Korostyński M; Department of Molecular Neuropharmacology, Institute of Pharmacology of the Polish Academy of Sciences, Smetna 12, 31-343, Krakow, Poland. .; Pokaż więcej
Źródło:: BMC neuroscience [BMC Neurosci] 2018 Sep 12; Vol. 19 (1), pp. 55. Date of Electronic Publication: 2018 Sep 12.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Alternative Splicing/*drug effects
Cerebrum/*drug effects
Protein Serine-Threonine Kinases/*metabolism
Psychotropic Drugs/*pharmacology
Transcription, Genetic/*drug effects
Animals ; Cerebrum/metabolism ; Computational Biology ; Doublecortin-Like Kinases ; Male ; Membrane Proteins ; Mice, Inbred C57BL ; Protein Isoforms/drug effects ; Protein Isoforms/metabolism ; RNA, Messenger/metabolism ; Saccharomyces cerevisiae Proteins

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Skocz do pozycji: 15.

Tytuł:: Analysis of the clinical significance of DCLK1 colorectal cancer using novel monoclonal antibodies against DCLK1.
Autorzy:: Dai T; Department of Immunology, College of Basic Medical Sciences, Harbin Medical University, Harbin, People's Republic of China, .
Hu Y; Department of Immunology, College of Basic Medical Sciences, Harbin Medical University, Harbin, People's Republic of China, .; Department of Immunology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan.; Department of Pathogen Biology, Shenzhen University School of Medicine, Shenzhen, People's Republic of China.
Lv F; Department of Immunology, College of Basic Medical Sciences, Harbin Medical University, Harbin, People's Republic of China, .
Ozawa T; Department of Immunology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan.
Sun X; Department of Immunology, College of Basic Medical Sciences, Harbin Medical University, Harbin, People's Republic of China, .
Huang J; Department of Immunology, College of Basic Medical Sciences, Harbin Medical University, Harbin, People's Republic of China, .
Han X; Department of Immunology, College of Basic Medical Sciences, Harbin Medical University, Harbin, People's Republic of China, .
Kishi H; Department of Immunology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan.
Muraguchi A; Department of Immunology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan.
Jin A; Department of Immunology, College of Basic Medical Sciences, Harbin Medical University, Harbin, People's Republic of China, .; Pokaż więcej
Źródło:: OncoTargets and therapy [Onco Targets Ther] 2018 Aug 21; Vol. 11, pp. 5047-5057. Date of Electronic Publication: 2018 Aug 21 (Print Publication: 2018).
Typ publikacji:: Journal Article

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Skocz do pozycji: 16.

Tytuł:: Prognostic impact of doublecortin-like kinase 1 expression in locally advanced rectal cancer treated with preoperative chemoradiotherapy.
Autorzy:: Harada Y; Division of Surgical Oncology, Department of Surgery, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.
Kazama S; Division of Surgical Oncology, Department of Surgery, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.; Department of Gastroenterological Surgery, Saitama Cancer Center, Saitama, Japan.
Morikawa T; Department of Pathology, The University of Tokyo, Tokyo, Japan.
Emoto S; Division of Surgical Oncology, Department of Surgery, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.
Murono K; Division of Surgical Oncology, Department of Surgery, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.
Kaneko M; Division of Surgical Oncology, Department of Surgery, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.
Sasaki K; Division of Surgical Oncology, Department of Surgery, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.
Otani K; Division of Surgical Oncology, Department of Surgery, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.
Nishikawa T; Division of Surgical Oncology, Department of Surgery, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.
Tanaka T; Division of Surgical Oncology, Department of Surgery, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.
Kiyomatsu T; Division of Surgical Oncology, Department of Surgery, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.
Kawai K; Division of Surgical Oncology, Department of Surgery, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.
Hata K; Division of Surgical Oncology, Department of Surgery, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.
Nozawa H; Division of Surgical Oncology, Department of Surgery, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.
Ishihara S; Division of Surgical Oncology, Department of Surgery, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.; Surgery Department, Sanno Hospital, International University of Health and Welfare, Tokyo, Japan.
Watanabe T; Division of Surgical Oncology, Department of Surgery, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.; Pokaż więcej
Źródło:: APMIS : acta pathologica, microbiologica, et immunologica Scandinavica [APMIS] 2018 Jun; Vol. 126 (6), pp. 486-493.
Typ publikacji:: Journal Article
MeSH Terms:: Chemoradiotherapy*
Intracellular Signaling Peptides and Proteins/*metabolism
Protein Serine-Threonine Kinases/*metabolism
Rectal Neoplasms/*diagnosis
Rectal Neoplasms/*genetics
Rectal Neoplasms/*therapy
Adult ; Aged ; Aged, 80 and over ; Cell Proliferation ; Doublecortin-Like Kinases ; Female ; Gene Expression Regulation, Neoplastic ; Genetic Markers ; Humans ; Intracellular Signaling Peptides and Proteins/genetics ; Lymphatic Metastasis/diagnosis ; Lymphatic Metastasis/genetics ; Male ; Middle Aged ; Preoperative Care ; Prognosis ; Protein Serine-Threonine Kinases/genetics

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Skocz do pozycji: 17.

Tytuł:: Association of doublecortin-like kinase 1 with tumor aggressiveness and poor biochemical recurrence-free survival in prostate cancer.
Autorzy:: Jiang D; Department of Urology, the Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
Xiao C; Department of Urology, the Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
Xian T; Department of Urology, the Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
Wang L; Department of General Surgery, Shenzhen Shajing Affiliated Hospital of Guangzhou Medical University, Shenzhen, China.
Mao Y; Department of Urology, the Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
Zhang J; Department of Urology, the Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
Pang J; Department of Urology, the Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.; Department of Urology, the Seventh Affiliated Hospital of Sun Yat-Sen University, Shenzhen, China.; Pokaż więcej
Źródło:: OncoTargets and therapy [Onco Targets Ther] 2018 Feb 28; Vol. 11, pp. 1077-1086. Date of Electronic Publication: 2018 Feb 28 (Print Publication: 2018).
Typ publikacji:: Journal Article

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Skocz do pozycji: 18.

Tytuł:: Lgr5High/DCLK1High phenotype is more common in early stage and intestinal subtypes of gastric carcinomas.
Autorzy:: Kalantari E; Oncopathology Research Center, Iran University of Medical Sciences, Tehran, Iran.; Oncopathology Research Center, Iran University of Medical Sciences, Tehran, Iran.
Asadi Lari MH; Department of Cellular and Physiological Sciences, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.; Oncopathology Research Center, Iran University of Medical Sciences, Tehran, Iran.
Roudi R; Oncopathology Research Center, Iran University of Medical Sciences, Tehran, Iran.
Korourian A; Department of Molecular Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran.
Madjd Z; Oncopathology Research Center, Iran University of Medical Sciences, Tehran, Iran.; Department of Molecular Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran.; Pokaż więcej
Źródło:: Cancer biomarkers : section A of Disease markers [Cancer Biomark] 2017 Dec 06; Vol. 20 (4), pp. 563-573.
Typ publikacji:: Journal Article
MeSH Terms:: Biomarkers, Tumor*
Phenotype*
Intracellular Signaling Peptides and Proteins/*metabolism
Protein Serine-Threonine Kinases/*metabolism
Receptors, G-Protein-Coupled/*metabolism
Stomach Neoplasms/*diagnosis
Stomach Neoplasms/*metabolism
Adult ; Aged ; Aged, 80 and over ; Doublecortin-Like Kinases ; Female ; Humans ; Immunohistochemistry ; Intracellular Signaling Peptides and Proteins/genetics ; Male ; Middle Aged ; Neoplasm Grading ; Neoplasm Metastasis ; Neoplasm Staging ; Protein Serine-Threonine Kinases/genetics ; Receptors, G-Protein-Coupled/genetics ; Stomach Neoplasms/genetics ; Tissue Array Analysis

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Skocz do pozycji: 19.

Tytuł:: Dclk1, a tumor stem cell marker, regulates pro-survival signaling and self-renewal of intestinal tumor cells.
Autorzy:: Chandrakesan P; Division of Digestive Diseases and Nutrition, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA. .; OU Cancer Institute, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA. .; Department of Veterans Affairs Medical Center, Oklahoma City, OK, USA. .
Yao J; Division of Digestive Diseases and Nutrition, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA.
Qu D; Division of Digestive Diseases and Nutrition, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA.; OU Cancer Institute, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.; Department of Veterans Affairs Medical Center, Oklahoma City, OK, USA.
May R; Division of Digestive Diseases and Nutrition, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA.; Department of Veterans Affairs Medical Center, Oklahoma City, OK, USA.
Weygant N; Division of Digestive Diseases and Nutrition, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA.
Ge Y; Division of Digestive Diseases and Nutrition, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA.; Beijing Chao-Yang Hospital Department of Oncology, Capital Medical University, Beijing, China.
Ali N; Division of Digestive Diseases and Nutrition, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA.; Department of Veterans Affairs Medical Center, Oklahoma City, OK, USA.
Sureban SM; Division of Digestive Diseases and Nutrition, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA.; Department of Veterans Affairs Medical Center, Oklahoma City, OK, USA.
Gude M; Division of Digestive Diseases and Nutrition, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA.; Access Endocrine, Diabetes and Thyroid center, Oklahoma City, OK, USA.
Vega K; Division of Digestive Diseases and Nutrition, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA.; Department of Medicine, National Jewish Health, Denver, CO, USA.
Bannerman-Menson E; COARE Biotechnology, Oklahoma City, OK, USA.
Xia L; Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.
Bronze M; Division of Digestive Diseases and Nutrition, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA.
An G; Beijing Chao-Yang Hospital Department of Oncology, Capital Medical University, Beijing, China. .
Houchen CW; Division of Digestive Diseases and Nutrition, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA. .; OU Cancer Institute, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA. .; Department of Veterans Affairs Medical Center, Oklahoma City, OK, USA. .; COARE Biotechnology, Oklahoma City, OK, USA. .; Pokaż więcej
Źródło:: Molecular cancer [Mol Cancer] 2017 Feb 01; Vol. 16 (1), pp. 30. Date of Electronic Publication: 2017 Feb 01.
Typ publikacji:: Journal Article
MeSH Terms:: Signal Transduction*
Cell Self Renewal/*genetics
Cell Survival/*genetics
Colonic Neoplasms/*genetics
Colonic Neoplasms/*metabolism
Intracellular Signaling Peptides and Proteins/*genetics
Intracellular Signaling Peptides and Proteins/*metabolism
Neoplastic Stem Cells/*metabolism
Protein Serine-Threonine Kinases/*genetics
Protein Serine-Threonine Kinases/*metabolism
Adenocarcinoma/genetics ; Adenocarcinoma/metabolism ; Adenocarcinoma/pathology ; Animals ; Cluster Analysis ; Colonic Neoplasms/pathology ; Disease Models, Animal ; Doublecortin-Like Kinases ; Epithelial-Mesenchymal Transition/genetics ; Female ; Gene Expression Profiling ; Gene Knockdown Techniques ; Genes, APC ; Humans ; Male ; Mice ; Mice, Transgenic ; Mutation ; Receptor, Notch1/metabolism

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Skocz do pozycji: 20.

Tytuł:: Evaluation of circulating cellular DCLK1 protein, as the most promising colorectal cancer stem cell marker, using immunoassay based methods.
Autorzy:: Mirzaei A; Department of Molecular Medicine, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran.; Bone and Joint Reconstruction Research Center, Shafa Orthopedic Hospital, Iran University of Medical Sciences, Tehran, Iran.
Madjd Z; Department of Molecular Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran.; Oncopathology Research Center, Iran University of Medical Sciences, Tehran, Iran.
Kadijani AA; Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Tavakoli-Yaraki M; Department of Biochemistry, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Modarresi MH; Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Verdi J; Department of Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Akbari A; Colorectal Research Center, Iran University of Medical Sciences, Tehran, Iran.
Tavoosidana G; Department of Molecular Medicine, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran.; Pokaż więcej
Źródło:: Cancer biomarkers : section A of Disease markers [Cancer Biomark] 2016 Sep 26; Vol. 17 (3), pp. 301-311.
Typ publikacji:: Journal Article
MeSH Terms:: Biomarkers, Tumor*
Colorectal Neoplasms/*metabolism
Intracellular Signaling Peptides and Proteins/*metabolism
Neoplastic Stem Cells/*metabolism
Protein Serine-Threonine Kinases/*metabolism
Adult ; Aged ; Case-Control Studies ; Colorectal Neoplasms/pathology ; Doublecortin-Like Kinases ; Female ; Humans ; Leukocytes, Mononuclear/metabolism ; Male ; Middle Aged ; Neoplasm Grading ; Neoplasm Staging ; ROC Curve ; Reproducibility of Results ; Young Adult

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