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    Tytuł:
    Divergent metabolism between Trypanosoma congolense and Trypanosoma brucei results in differential sensitivity to metabolic inhibition.
    Autorzy:
    Steketee PC; The Roslin Institute, Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, United Kingdom.
    Dickie EA; Wellcome Centre for Integrative Parasitology, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom.
    Iremonger J; The Roslin Institute, Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, United Kingdom.
    Crouch K; Wellcome Centre for Integrative Parasitology, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom.
    Paxton E; The Roslin Institute, Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, United Kingdom.
    Jayaraman S; The Roslin Institute, Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, United Kingdom.
    Alfituri OA; The Roslin Institute, Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, United Kingdom.
    Awuah-Mensah G; School of Life Sciences, University of Nottingham, Nottingham, United Kingdom.
    Ritchie R; Wellcome Centre for Integrative Parasitology, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom.
    Schnaufer A; Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh, United Kingdom.
    Rowan T; Global Alliance for Livestock Veterinary Medicines, Edinburgh, United Kingdom.
    de Koning HP; Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom.
    Gadelha C; School of Life Sciences, University of Nottingham, Nottingham, United Kingdom.
    Wickstead B; School of Life Sciences, University of Nottingham, Nottingham, United Kingdom.
    Barrett MP; Wellcome Centre for Integrative Parasitology, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom.; Glasgow Polyomics, University of Glasgow, Glasgow, United Kingdom.
    Morrison LJ; The Roslin Institute, Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, United Kingdom.
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    Źródło:
    PLoS pathogens [PLoS Pathog] 2021 Jul 26; Vol. 17 (7), pp. e1009734. Date of Electronic Publication: 2021 Jul 26 (Print Publication: 2021).
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Trypanosoma brucei brucei/*metabolism
    Trypanosoma congolense/*metabolism
    Animals ; Lipid Regulating Agents/pharmacology ; Mice ; Trypanosoma brucei brucei/drug effects ; Trypanosoma congolense/drug effects ; Trypanosomiasis, African
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Activity of Compounds from Temperate Propolis against Trypanosoma brucei and Leishmania mexicana .
    Autorzy:
    Alotaibi A; Strathclyde Institute of Pharmacy and Biomedical Science, University of Strathclyde, 161 Cathedral Street, Glasgow G4 0RE, UK.
    Ebiloma GU; Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, UK.; School of Health and Life Sciences, Teesside University, Middlesbrough TS1 3BX, UK.
    Williams R; IBEHR, School of Health and Life Science, University of the West of Scotland, High Street, Paisley PA1 2BE, UK.
    Alfayez IA; Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, UK.; Qassim Health Cluster, Ministry of Health, Buraydah 52367, Saudi Arabia.; Department of Pharmaceutical Chemistry, College of Clinical Pharmacy, Imam Abdulrahman Bin Faisal University, Dammam 31441, Saudi Arabia.
    Natto MJ; Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, UK.
    Alenezi S; Strathclyde Institute of Pharmacy and Biomedical Science, University of Strathclyde, 161 Cathedral Street, Glasgow G4 0RE, UK.
    Siheri W; Department of Pharmacognosy and Natural Products, Faculty of Pharmacy, University of Tripoli, Tripoli 50676, Libya.
    AlQarni M; Department of Pharmaceutical Chemistry, College of Clinical Pharmacy, Imam Abdulrahman Bin Faisal University, Dammam 31441, Saudi Arabia.
    Igoli JO; Strathclyde Institute of Pharmacy and Biomedical Science, University of Strathclyde, 161 Cathedral Street, Glasgow G4 0RE, UK.; Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, UK.; Department of Chemistry, University of Agriculture, Makurdi PMB 2373, Nigeria.
    Fearnley J; BeeVital, Whitby, North Yorkshire YO22 5JR, UK.
    De Koning HP; Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, UK.
    Watson DG; Strathclyde Institute of Pharmacy and Biomedical Science, University of Strathclyde, 161 Cathedral Street, Glasgow G4 0RE, UK.
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    Źródło:
    Molecules (Basel, Switzerland) [Molecules] 2021 Jun 26; Vol. 26 (13). Date of Electronic Publication: 2021 Jun 26.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Leishmania mexicana/*drug effects
    Propolis/*analysis
    Propolis/*pharmacology
    Trypanocidal Agents/*chemistry
    Trypanosoma brucei brucei/*drug effects
    Cinnamates/chemistry ; Flavanones/chemistry ; Flavonoids/chemistry ; Kaempferols/chemistry ; Magnetic Resonance Spectroscopy ; Mass Spectrometry ; Poland ; Propolis/chemistry ; United Kingdom
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Instability of aquaglyceroporin (AQP) 2 contributes to drug resistance in Trypanosoma brucei.
    Autorzy:
    Quintana JF; School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, United Kingdom.
    Bueren-Calabuig J; School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, United Kingdom.
    Zuccotto F; School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, United Kingdom.
    de Koning HP; Institute of Infection, Immunity, and Inflammation, University of Glasgow, Glasgow, United Kingdom.
    Horn D; School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, United Kingdom.
    Field MC; School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, United Kingdom.; Institute of Parasitology, Biology Centre, Czech Academy of Sciences, Ceske Budejovice, Czech Republic.
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    Źródło:
    PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2020 Jul 09; Vol. 14 (7), pp. e0008458. Date of Electronic Publication: 2020 Jul 09 (Print Publication: 2020).
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Drug Resistance*
    Trypanosoma brucei brucei*
    Aquaglyceroporins/*metabolism
    Trypanocidal Agents/*pharmacology
    Trypanosomiasis, African/*parasitology
    Amino Acid Sequence ; Animals ; Aquaglyceroporins/chemistry ; Protein Stability
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    European propolis is highly active against trypanosomatids including Crithidia fasciculata.
    Autorzy:
    Alotaibi A; University of Strathclyde, Strathclyde Institute of Pharmacy and Biomedical Science, 161 Cathedral Street, Glasgow, G4 0RE, UK.
    Ebiloma GU; Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8TA, UK.
    Williams R; IBEHR, School of Health and Life Science, University of the West of Scotland, High Street, Paisley, PA1 2BE, UK.
    Alenezi S; University of Strathclyde, Strathclyde Institute of Pharmacy and Biomedical Science, 161 Cathedral Street, Glasgow, G4 0RE, UK.
    Donachie AM; Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8TA, UK.
    Guillaume S; IBEHR, School of Health and Life Science, University of the West of Scotland, High Street, Paisley, PA1 2BE, UK.
    Igoli JO; University of Strathclyde, Strathclyde Institute of Pharmacy and Biomedical Science, 161 Cathedral Street, Glasgow, G4 0RE, UK.; Department of Chemistry, University of Agriculture, PMB 2373, Makurdi, Nigeria.
    Fearnley J; BeeVital, Whitby, North Yorkshire, YO22 5JR, UK.
    de Koning HP; Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8TA, UK.
    Watson DG; University of Strathclyde, Strathclyde Institute of Pharmacy and Biomedical Science, 161 Cathedral Street, Glasgow, G4 0RE, UK. .
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    Źródło:
    Scientific reports [Sci Rep] 2019 Aug 06; Vol. 9 (1), pp. 11364. Date of Electronic Publication: 2019 Aug 06.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Antiprotozoal Agents/*pharmacology
    Crithidia fasciculata/*drug effects
    Propolis/*pharmacology
    Trypanosoma brucei brucei/*drug effects
    Trypanosoma congolense/*drug effects
    Animals ; Antiprotozoal Agents/therapeutic use ; Chromatography, Liquid ; Euglenozoa Infections/drug therapy ; Flavanones/analysis ; Flavanones/pharmacology ; Flavonoids/analysis ; Flavonoids/pharmacology ; Mass Spectrometry ; Propolis/chemistry ; Propolis/therapeutic use
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Isolation of a Novel Flavanonol and an Alkylresorcinol with Highly Potent Anti-Trypanosomal Activity from Libyan propolis.
    Autorzy:
    Siheri W; Strathclyde Institute of Pharmacy and Biomedical Science, University of Strathclyde, 161 Cathedral Street, Glasgow G4 0RE, UK. .
    Ebiloma GU; Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, UK. .
    Igoli JO; Strathclyde Institute of Pharmacy and Biomedical Science, University of Strathclyde, 161 Cathedral Street, Glasgow G4 0RE, UK. .; Department of Chemistry, University of Agriculture, PMB 2373 Makurdi, Nigeria. .
    Gray AI; Strathclyde Institute of Pharmacy and Biomedical Science, University of Strathclyde, 161 Cathedral Street, Glasgow G4 0RE, UK. .
    Biddau M; Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, UK. .
    Akrachalanont P; Strathclyde Institute of Pharmacy and Biomedical Science, University of Strathclyde, 161 Cathedral Street, Glasgow G4 0RE, UK. .
    Alenezi S; Strathclyde Institute of Pharmacy and Biomedical Science, University of Strathclyde, 161 Cathedral Street, Glasgow G4 0RE, UK. .
    Alwashih MA; General Directorate of Medical Services, Ministry of Interior, Riyadh 13321, Saudi Arabia. .
    Edrada-Ebel R; Strathclyde Institute of Pharmacy and Biomedical Science, University of Strathclyde, 161 Cathedral Street, Glasgow G4 0RE, UK. .
    Muller S; Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, UK. .
    Lawrence CE; Strathclyde Institute of Pharmacy and Biomedical Science, University of Strathclyde, 161 Cathedral Street, Glasgow G4 0RE, UK. .
    Fearnley J; BeeVital, Whitby, North Yorkshire YO22 5JR, UK. .
    Watson DG; Strathclyde Institute of Pharmacy and Biomedical Science, University of Strathclyde, 161 Cathedral Street, Glasgow G4 0RE, UK. .
    De Koning HP; Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, UK. Harry.De-Koning@glasgow.ac.uk.
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    Źródło:
    Molecules (Basel, Switzerland) [Molecules] 2019 Mar 15; Vol. 24 (6). Date of Electronic Publication: 2019 Mar 15.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Antiprotozoal Agents/*chemistry
    Cell Proliferation/*drug effects
    Propolis/*chemistry
    Trypanosoma brucei brucei/*drug effects
    Animals ; Antiprotozoal Agents/pharmacology ; Caenorhabditis elegans/drug effects ; Caenorhabditis elegans/pathogenicity ; Cell Line ; Fibroblasts/drug effects ; Humans ; Libya ; Metabolomics ; Plasmodium falciparum/drug effects ; Plasmodium falciparum/pathogenicity ; Polyphenols/chemistry ; Polyphenols/pharmacology ; Propolis/pharmacology ; Trichinella spiralis/drug effects ; Trichinella spiralis/pathogenicity ; Trypanosoma brucei brucei/pathogenicity
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Potent Antitrypanosomal Activities of 3-Aminosteroids against African Trypanosomes: Investigation of Cellular Effects and of Cross-Resistance with Existing Drugs.
    Autorzy:
    Nnadi CO; Institute of Pharmaceutical Biology and Phytochemistry (IPBP), University of Münster, Pharma Campus Corrensstraße 48, D-48149 Münster, Germany. .; Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Nigeria Nsukka, Enugu 410001, Nigeria. .
    Ebiloma GU; Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, UK. .; Department of Applied Biology, Kyoto Institute of Technology, Kyoto 606-8585, Japan. .
    Black JA; The Wellcome Trust Centre for Molecular Parasitology, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow G12 8TA, UK. .; Department of Cell and Molecular Biology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto 14049-900, Brazil. .
    Nwodo NJ; Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Nigeria Nsukka, Enugu 410001, Nigeria. .
    Lemgruber L; Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, UK. .
    Schmidt TJ; Institute of Pharmaceutical Biology and Phytochemistry (IPBP), University of Münster, Pharma Campus Corrensstraße 48, D-48149 Münster, Germany. .de.
    de Koning HP; Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, UK. Harry.De-Koning@glasgow.ac.uk.
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    Źródło:
    Molecules (Basel, Switzerland) [Molecules] 2019 Jan 12; Vol. 24 (2). Date of Electronic Publication: 2019 Jan 12.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Drug Resistance*
    Cholestanols/*pharmacology
    Trypanocidal Agents/*pharmacology
    Trypanosoma brucei brucei/*drug effects
    Adenosine Triphosphate/metabolism ; Animals ; Cell Cycle/drug effects ; Cholestanols/chemistry ; Inhibitory Concentration 50 ; Intracellular Space/metabolism ; Membrane Potential, Mitochondrial/drug effects ; Molecular Structure ; Trypanocidal Agents/chemistry ; Trypanosomiasis, African/drug therapy
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Pyrimidine biosynthesis is not an essential function for Trypanosoma brucei bloodstream forms.
    Autorzy:
    Ali JA; Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom.
    Tagoe DN
    Munday JC
    Donachie A
    Morrison LJ
    de Koning HP
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    Źródło:
    PloS one [PLoS One] 2013; Vol. 8 (3), pp. e58034. Date of Electronic Publication: 2013 Mar 07.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Pyrimidines/*biosynthesis
    Trypanosoma brucei brucei/*metabolism
    Animal Diseases ; Animals ; Biological Transport ; Female ; Gene Knockout Techniques ; Mice ; Orotate Phosphoribosyltransferase/genetics ; Orotate Phosphoribosyltransferase/metabolism ; Starvation ; Trypanosoma brucei brucei/drug effects ; Trypanosoma brucei brucei/genetics ; Trypanosoma brucei brucei/growth & development ; Trypanosomiasis, African/veterinary ; Uracil/metabolism ; Uridine Phosphorylase/genetics ; Uridine Phosphorylase/metabolism
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Detection of arsenical drug resistance in Trypanosoma brucei with a simple fluorescence test.
    Autorzy:
    Stewart ML; University of Glasgow, Division of Infection and Immunity, Institute of Biomedical and Life Sciences, The Joseph Black Building, Glasgow G12 8QQ, UK.
    Krishna S
    Burchmore RJ
    Brun R
    de Koning HP
    Boykin DW
    Tidwell RR
    Hall JE
    Barrett MP
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    Źródło:
    Lancet (London, England) [Lancet] 2005 Aug 6-12; Vol. 366 (9484), pp. 486-7.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Drug Resistance*
    Melarsoprol/*pharmacology
    Trypanocidal Agents/*pharmacology
    Trypanosoma brucei brucei/*drug effects
    Animals ; Arsenicals/pharmacology ; Diamide ; Fluorescence ; Mice ; Mice, Inbred ICR ; Microbial Sensitivity Tests/methods ; Nucleoside Transport Proteins/metabolism ; Trypanosoma brucei brucei/metabolism
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Hypoxanthine uptake through a purine-selective nucleobase transporter in Trypanosoma brucei brucei procyclic cells is driven by protonmotive force.
    Autorzy:
    de Koning HP; Research School of Biosciences, University of Kent, Canterbury, United Kingdom.
    Jarvis SM
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    Źródło:
    European journal of biochemistry [Eur J Biochem] 1997 Aug 01; Vol. 247 (3), pp. 1102-10.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Carrier Proteins/*metabolism
    Hypoxanthine/*metabolism
    Purines/*metabolism
    Trypanosoma brucei brucei/*metabolism
    Animals ; Hydrogen-Ion Concentration ; Kinetics ; Membrane Potentials ; Osmolar Concentration ; Protons ; Substrate Specificity ; Trypanosoma brucei brucei/cytology
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
      Wyświetlanie 1-10 z 10

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