Targeting aurora kinases as a potential prognostic and therapeutical biomarkers in pediatric acute lymphoblastic leukaemia.
Autorzy :
Moreira-Nunes CA; Pharmacogenetics Laboratory, Drug Research and Development Center (NPDM), Federal University of Ceará, Coronel Nunes de Melo st, n 1000, Rodolfo Teófilo, Fortaleza, CE, CEP: 60416-000, Brazil. . Mesquita FP; Pharmacogenetics Laboratory, Drug Research and Development Center (NPDM), Federal University of Ceará, Coronel Nunes de Melo st, n 1000, Rodolfo Teófilo, Fortaleza, CE, CEP: 60416-000, Brazil. Portilho AJS; Pharmacogenetics Laboratory, Drug Research and Development Center (NPDM), Federal University of Ceará, Coronel Nunes de Melo st, n 1000, Rodolfo Teófilo, Fortaleza, CE, CEP: 60416-000, Brazil. Mello Júnior FAR; Molecular Biology Laboratory, Ophir Loyola Hospital, Belém, PA, Brazil. Maués JHDS; Laboratory of Human Cytogenetics, Institute of Biological Sciences, Federal University of Pará, Belém, PA, Brazil. Pantoja LDC; Department of Pediatrics, Octávio Lobo Children's Hospital, Belém, PA, Brazil. Wanderley AV; Department of Pediatrics, Octávio Lobo Children's Hospital, Belém, PA, Brazil. Khayat AS; Oncology Research Center, João de Barros Barreto University Hospital, Federal University of Pará, Belém, PA, Brazil. Zuercher WJ; Division of Chemical Biology and Medicinal Chemistry, University of North Carolina at Chapel Hill, Eshelman School of Pharmacy, Chapel Hill, NC, USA. Montenegro RC; Pharmacogenetics Laboratory, Drug Research and Development Center (NPDM), Federal University of Ceará, Coronel Nunes de Melo st, n 1000, Rodolfo Teófilo, Fortaleza, CE, CEP: 60416-000, Brazil. deMoraes-Filho MO; Pharmacogenetics Laboratory, Drug Research and Development Center (NPDM), Federal University of Ceará, Coronel Nunes de Melo st, n 1000, Rodolfo Teófilo, Fortaleza, CE, CEP: 60416-000, Brazil. deMoraesMEA; Pharmacogenetics Laboratory, Drug Research and Development Center (NPDM), Federal University of Ceará, Coronel Nunes de Melo st, n 1000, Rodolfo Teófilo, Fortaleza, CE, CEP: 60416-000, Brazil.
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Źródło :
Scientific reports [Sci Rep] 2020 Dec 04; Vol. 10 (1), pp. 21272. Date of Electronic Publication: 2020 Dec 04.
Telomere Length and Hematological Disorders: A Review.
Autorzy :
Nogueira BMD; Pharmacogenetics Laboratory, Drug Research and Development Center (NPDM), Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, CE, Brazil. Machado CB; Pharmacogenetics Laboratory, Drug Research and Development Center (NPDM), Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, CE, Brazil. Montenegro RC; Pharmacogenetics Laboratory, Drug Research and Development Center (NPDM), Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, CE, Brazil. DEMoraesMEA; Pharmacogenetics Laboratory, Drug Research and Development Center (NPDM), Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, CE, Brazil. Moreira-Nunes CA; Pharmacogenetics Laboratory, Drug Research and Development Center (NPDM), Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, CE, Brazil .
Lyophilised tilapia skin as a xenograft for superficial partial thickness burns: a novel preparation and storage technique.
Autorzy :
Júnior EML; Burn Treatment Center, Dr José Frota Institute, Fortaleza, CE, Brazil. deMoraes Filho MO; Clinical Pharmacology Unit, Drug Research and Development Center, Federal University of Ceará (UFC), Fortaleza, CE, Brazil. Costa BA; Clinical Pharmacology Unit, Drug Research and Development Center, Federal University of Ceará (UFC), Fortaleza, CE, Brazil. Alves APNN; Nursing, Dentistry and Pharmacy School of the Federal University of Ceará, Fortaleza, CE, Brazil. deMoraesMEA; Clinical Pharmacology Unit, Drug Research and Development Center, Federal University of Ceará (UFC), Fortaleza, CE, Brazil. do Nascimento Uchôa AM; Burn Treatment Center, Dr José Frota Institute, Fortaleza, CE, Brazil. Martins CB; Clinical Pharmacology Unit, Drug Research and Development Center, Federal University of Ceará (UFC), Fortaleza, CE, Brazil. de Jesus Pinheiro Gomes Bandeira T; Christus University Center, Fortaleza, CE, Brazil. Rodrigues FAR; Clinical Pharmacology Unit, Drug Research and Development Center, Federal University of Ceará (UFC), Fortaleza, CE, Brazil.; Federal Institute of Education, Science and Technology of Ceará (IFCE)-Campus Jaguaribe, CE, Brazil. Paier CRK; Clinical Pharmacology Unit, Drug Research and Development Center, Federal University of Ceará (UFC), Fortaleza, CE, Brazil. Lima FC; Christus University Center, Fortaleza, CE, Brazil. Júnior FRS; Burn Treatment Center, Dr José Frota Institute, Fortaleza, CE, Brazil.
In silico study of azithromycin, chloroquine and hydroxychloroquine and their potential mechanisms of action against SARS-CoV-2 infection.
Autorzy :
Braz HLB; Postgraduate Program in Morphological Science, Department of Morphology, School of Medicine, Federal University of Ceara, Delmiro de Farias St., 60.430-170, Fortaleza-CE, Brazil; Drug Research and Development Center, Federal University of Ceara, Coronel Nunes de Melo St., 1000, 60.430-275, Fortaleza-CE, Brazil. Silveira JAM; Drug Research and Development Center, Federal University of Ceara, Coronel Nunes de Melo St., 1000, 60.430-275, Fortaleza-CE, Brazil; Department of Physiology and Pharmacology, School of Medicine, Federal University of Ceara, Coronel Nunes de Melo St., 1127, 60.430-275, Fortaleza-CE, Brazil. Marinho AD; Drug Research and Development Center, Federal University of Ceara, Coronel Nunes de Melo St., 1000, 60.430-275, Fortaleza-CE, Brazil; Department of Physiology and Pharmacology, School of Medicine, Federal University of Ceara, Coronel Nunes de Melo St., 1127, 60.430-275, Fortaleza-CE, Brazil. deMoraesMEA; Drug Research and Development Center, Federal University of Ceara, Coronel Nunes de Melo St., 1000, 60.430-275, Fortaleza-CE, Brazil; Department of Physiology and Pharmacology, School of Medicine, Federal University of Ceara, Coronel Nunes de Melo St., 1127, 60.430-275, Fortaleza-CE, Brazil. Moraes Filho MO; Drug Research and Development Center, Federal University of Ceara, Coronel Nunes de Melo St., 1000, 60.430-275, Fortaleza-CE, Brazil; Department of Physiology and Pharmacology, School of Medicine, Federal University of Ceara, Coronel Nunes de Melo St., 1127, 60.430-275, Fortaleza-CE, Brazil. Monteiro HSA; Drug Research and Development Center, Federal University of Ceara, Coronel Nunes de Melo St., 1000, 60.430-275, Fortaleza-CE, Brazil; Department of Physiology and Pharmacology, School of Medicine, Federal University of Ceara, Coronel Nunes de Melo St., 1127, 60.430-275, Fortaleza-CE, Brazil. Jorge RJB; Drug Research and Development Center, Federal University of Ceara, Coronel Nunes de Melo St., 1000, 60.430-275, Fortaleza-CE, Brazil; Department of Physiology and Pharmacology, School of Medicine, Federal University of Ceara, Coronel Nunes de Melo St., 1127, 60.430-275, Fortaleza-CE, Brazil. Electronic address: .
A semi-synthetic flavonoid from Bauhinia pulchella stem attenuates inflammatory osteolysis in periodontitis in rats: Impact on cytokine levels, oxidative stress, and RANK/RANKL/OPG pathway.
Autorzy :
Pinto IR; Northeast Biotechnology Network - Ph.D. Program, Federal University of Ceará, Brazil. Chaves HV; School of Dentistry, Federal University of Ceará, Sobral, Ceará, Brazil. Freire JMO; Northeast Biotechnology Network - Ph.D. Program, Federal University of Ceará, Brazil. de Sousa LHT; Northeast Biotechnology Network - Ph.D. Program, Federal University of Ceará, Brazil. Monteiro DAM; School of Medicine, Federal University of Ceará, Sobral, Ceará, Brazil. Costa JJDN; School of Medicine, University Center INTA - UNINTA, Sobral, Ceará, Brazil. Pereira KMA; Department of Morphology, School of Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil. Santiago GMP; Postgraduate Program in Chemistry, Federal University of Ceará, Fortaleza, Ceará, Brazil. de Sousa LM; Postgraduate Program in Chemistry, Federal University of Ceará, Fortaleza, Ceará, Brazil. da Silva MR; Postgraduate Program in Chemistry, Federal University of Ceará, Fortaleza, Ceará, Brazil. Monteiro AO; Postgraduate Program in Chemistry, Federal University of Ceará, Fortaleza, Ceará, Brazil. Montenegro RC; Drug Research and Development Center (NPDM), Federal University of Ceará, Fortaleza, Ceará, Brazil. deMoraesMEA; Drug Research and Development Center (NPDM), Federal University of Ceará, Fortaleza, Ceará, Brazil. Filho GC; School of Medicine, Federal University of Ceará, Sobral, Ceará, Brazil. Pinto VPT; School of Medicine, Federal University of Ceará, Sobral, Ceará, Brazil. Bezerra MM; School of Medicine, Federal University of Ceará, Sobral, Ceará, Brazil; Drug Research and Development Center (NPDM), Federal University of Ceará, Fortaleza, Ceará, Brazil. Electronic address: .
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Źródło :
Archives of oral biology [Arch Oral Biol] 2020 Sep; Vol. 117, pp. 104816. Date of Electronic Publication: 2020 Jun 10.
22β-hydroxytingenone reduces proliferation and invasion of human melanoma cells.
Autorzy :
Aranha ESP; Faculty of Pharmaceutical Sciences, Post Graduate Program in Biodiversity and Biotechnology of the Amazon (Bionorte), Federal University of Amazonas, Manaus, Amazonas, Brazil. Electronic address: . da Silva EL; Drug Research and Development Center (NPDM), Federal University of Ceará, Fortaleza, Ceará, Brazil. Mesquita FP; Drug Research and Development Center (NPDM), Federal University of Ceará, Fortaleza, Ceará, Brazil. de Sousa LB; Faculty of Pharmaceutical Sciences, Federal University of Amazonas, Manaus, Amazon, Brazil. da Silva FMA; Department of Chemistry, Federal University of Amazonas, Manaus, Amazonas, Brazil. Rocha WC; Health and Biotechnology Institute, Federal University of Amazonas, Coari, Amazonas, Brazil. Lima ES; Faculty of Pharmaceutical Sciences, Federal University of Amazonas, Manaus, Amazon, Brazil. Koolen HHF; Metabolomics and Mass Spectrometry Research Group, Amazonas State University, Manaus, Amazonas, Brazil. deMoraesMEA; Drug Research and Development Center (NPDM), Federal University of Ceará, Fortaleza, Ceará, Brazil. Montenegro RC; Drug Research and Development Center (NPDM), Federal University of Ceará, Fortaleza, Ceará, Brazil. de Vasconcellos MC; Faculty of Pharmaceutical Sciences, Federal University of Amazonas, Manaus, Amazon, Brazil. Electronic address: .
MAPK14 (p38α) inhibition effects against metastatic gastric cancer cells: A potential biomarker and pharmacological target.
Autorzy :
Mesquita FP; Laboratory of Pharmacogenetics, Drug Research and Development Center (NPDM), Federal University of Ceará, Fortaleza, Brazil. Moreira-Nunes CA; Laboratory of Pharmacogenetics, Drug Research and Development Center (NPDM), Federal University of Ceará, Fortaleza, Brazil. da Silva EL; Laboratory of Pharmacogenetics, Drug Research and Development Center (NPDM), Federal University of Ceará, Fortaleza, Brazil. Lima LB; Laboratory of Pharmacogenetics, Drug Research and Development Center (NPDM), Federal University of Ceará, Fortaleza, Brazil. Daniel JP; Laboratory of Pharmacogenetics, Drug Research and Development Center (NPDM), Federal University of Ceará, Fortaleza, Brazil. Zuerker WJ; Division of Chemical Biology and Medicinal Chemistry, University of North Carolina at Chapel Hill, Eshelman School of Pharmacy, United States of America. Brayner M; Laboratory of Pharmacogenetics, Drug Research and Development Center (NPDM), Federal University of Ceará, Fortaleza, Brazil. deMoraesMEA; Laboratory of Pharmacogenetics, Drug Research and Development Center (NPDM), Federal University of Ceará, Fortaleza, Brazil. Montenegro RC; Laboratory of Pharmacogenetics, Drug Research and Development Center (NPDM), Federal University of Ceará, Fortaleza, Brazil. Electronic address: .
A Randomized Comparison Study of Lyophilized Nile Tilapia Skin and Silver-Impregnated Sodium Carboxymethylcellulose for the Treatment of Superficial Partial-Thickness Burns.
Autorzy :
Lima Júnior EM; Burn Treatment Center, Dr. José Frota Institute, Fortaleza, CE, Brazil. deMoraes Filho MO; Clinical Pharmacology Unit, Drug Research and Development Center, Federal University of Ceará (UFC), Fortaleza, CE, Brazil. Costa BA; Clinical Pharmacology Unit, Drug Research and Development Center, Federal University of Ceará (UFC), Fortaleza, CE, Brazil. Fechine FV; Clinical Pharmacology Unit, Drug Research and Development Center, Federal University of Ceará (UFC), Fortaleza, CE, Brazil. Rocha MBS; Clinical Pharmacology Unit, Drug Research and Development Center, Federal University of Ceará (UFC), Fortaleza, CE, Brazil. Vale ML; Clinical Pharmacology Unit, Drug Research and Development Center, Federal University of Ceará (UFC), Fortaleza, CE, Brazil.; Graduate Program in Morphofunctional Sciences, School of Medicine, Federal University of Ceará (UFC), Fortaleza, CE, Brazil. Diógenes AKL; Graduate Program in Morphofunctional Sciences, School of Medicine, Federal University of Ceará (UFC), Fortaleza, CE, Brazil. Uchôa AMDN; Burn Treatment Center, Dr. José Frota Institute, Fortaleza, CE, Brazil. Silva Júnior FR; Burn Treatment Center, Dr. José Frota Institute, Fortaleza, CE, Brazil. Martins CB; Clinical Pharmacology Unit, Drug Research and Development Center, Federal University of Ceará (UFC), Fortaleza, CE, Brazil. Bandeira TJPG; School of Medicine, Christus University Center (UNICHRISTUS), Fortaleza, CE, Brazil. Rocha Rodrigues FA; Clinical Pharmacology Unit, Drug Research and Development Center, Federal University of Ceará (UFC), Fortaleza, CE, Brazil.; Federal Institute of Education, Science and Technology of Ceará (IFCE) - Campus, Jaguaribe, Jaguaribe, CE, Brazil. Paier CRK; Clinical Pharmacology Unit, Drug Research and Development Center, Federal University of Ceará (UFC), Fortaleza, CE, Brazil. deMoraesMEA; Clinical Pharmacology Unit, Drug Research and Development Center, Federal University of Ceará (UFC), Fortaleza, CE, Brazil.
PARP Inhibitors as Therapeutic Options for Tyrosine Kinase-dependent Leukemia: A Review.
Autorzy :
Machado CB; Pharmacogenetics Laboratory, Drug Research and Development Center (NPDM), Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, Brazil. DA Silva EL; Pharmacogenetics Laboratory, Drug Research and Development Center (NPDM), Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, Brazil. DEMoraes Filho MO; Pharmacogenetics Laboratory, Drug Research and Development Center (NPDM), Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, Brazil. DEMoraesMEA; Pharmacogenetics Laboratory, Drug Research and Development Center (NPDM), Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, Brazil. Moreira-Nunes CA; Pharmacogenetics Laboratory, Drug Research and Development Center (NPDM), Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, Brazil .
Leu124Serfs*26, a novel AGPAT2 mutation in congenital generalized lipodystrophy with early cardiovascular complications.
Autorzy :
Montenegro Junior RM; 1Brazilian Group for the Study of Inherited and Acquired Lipodystrophies (BRAZLIPO), Faculdade de Medicina, Universidade Federal do Ceará, Rua Professor Costa Mendes, 1608, Rodolfo Teófilo, Fortaleza, Ceará 60416200 Brazil. Lima GEDCP; 1Brazilian Group for the Study of Inherited and Acquired Lipodystrophies (BRAZLIPO), Faculdade de Medicina, Universidade Federal do Ceará, Rua Professor Costa Mendes, 1608, Rodolfo Teófilo, Fortaleza, Ceará 60416200 Brazil. Fernandes VO; 1Brazilian Group for the Study of Inherited and Acquired Lipodystrophies (BRAZLIPO), Faculdade de Medicina, Universidade Federal do Ceará, Rua Professor Costa Mendes, 1608, Rodolfo Teófilo, Fortaleza, Ceará 60416200 Brazil. Montenegro APDR; 1Brazilian Group for the Study of Inherited and Acquired Lipodystrophies (BRAZLIPO), Faculdade de Medicina, Universidade Federal do Ceará, Rua Professor Costa Mendes, 1608, Rodolfo Teófilo, Fortaleza, Ceará 60416200 Brazil. Ponte CMM; 1Brazilian Group for the Study of Inherited and Acquired Lipodystrophies (BRAZLIPO), Faculdade de Medicina, Universidade Federal do Ceará, Rua Professor Costa Mendes, 1608, Rodolfo Teófilo, Fortaleza, Ceará 60416200 Brazil. Martins LV; 1Brazilian Group for the Study of Inherited and Acquired Lipodystrophies (BRAZLIPO), Faculdade de Medicina, Universidade Federal do Ceará, Rua Professor Costa Mendes, 1608, Rodolfo Teófilo, Fortaleza, Ceará 60416200 Brazil. Pinheiro DP; 2Drug Research and Development Center-NPDM, Universidade Federal do Ceará, Fortaleza, Brazil. deMoraesMEA; 2Drug Research and Development Center-NPDM, Universidade Federal do Ceará, Fortaleza, Brazil. deMoraes Filho MO; 2Drug Research and Development Center-NPDM, Universidade Federal do Ceará, Fortaleza, Brazil. d'Alva CB; 1Brazilian Group for the Study of Inherited and Acquired Lipodystrophies (BRAZLIPO), Faculdade de Medicina, Universidade Federal do Ceará, Rua Professor Costa Mendes, 1608, Rodolfo Teófilo, Fortaleza, Ceará 60416200 Brazil.
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Źródło :
Diabetology & metabolic syndrome [Diabetol Metab Syndr] 2020 Apr 06; Vol. 12, pp. 28. Date of Electronic Publication: 2020 Apr 06 (Print Publication: 2020).
Establishment of Drug-resistant Cell Lines as a Model in Experimental Oncology: A Review.
Autorzy :
Amaral MVS; Unichristus University Center, Faculty of Biomedicine, Fortaleza, Brazil. DE Sousa Portilho AJ; Pharmacogenetics Laboratory, Drug Research and Development Center (NPDM), Federal University of Ceará, Fortaleza, Brazil. DA Silva EL; Pharmacogenetics Laboratory, Drug Research and Development Center (NPDM), Federal University of Ceará, Fortaleza, Brazil. DE Oliveira Sales L; Pharmacogenetics Laboratory, Drug Research and Development Center (NPDM), Federal University of Ceará, Fortaleza, Brazil. DA Silva Maués JH; Laboratory of Human Cytogenetics, Institute of Biological Sciences, Federal University of Pará, Belém, Brazil. DEMoraesMEA; Pharmacogenetics Laboratory, Drug Research and Development Center (NPDM), Federal University of Ceará, Fortaleza, Brazil. Moreira-Nunes CA; Unichristus University Center, Faculty of Biomedicine, Fortaleza, Brazil .; Pharmacogenetics Laboratory, Drug Research and Development Center (NPDM), Federal University of Ceará, Fortaleza, Brazil.
Protective effect of Platymiscium floribundum Vog. in tree extract on periodontitis inflammation in rats.
Autorzy :
Freire JMO; Northeast Biotechnology Network-Ph.D. Program, Federal University of Ceará, Sobral, Ceará, Brazil. Chaves HV; Northeast Biotechnology Network-Ph.D. Program, Federal University of Ceará, Sobral, Ceará, Brazil. Teixeira AH; School of Dentistry, Federal University of Ceará, Sobral, Ceará, Brazil. de Sousa LHT; Northeast Biotechnology Network-Ph.D. Program, Federal University of Ceará, Sobral, Ceará, Brazil. Pinto IR; Northeast Biotechnology Network-Ph.D. Program, Federal University of Ceará, Sobral, Ceará, Brazil. Costa JJDN; School of Medicine, University CenterINTA-UNINTA, Sobral, Ceará, Brazil. de Sousa NA; School of Medicine, Federal University of Ceará, Sobral, Ceará, Brazil. Pereira KMA; Department of Morphology, School of Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil. Girão VCC; Department of Morphology, School of Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil. Ferreira VCS; Postgraduate Program in Morphofunctional Sciences, Department of Morphology, School of Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil. Dos Santos JEÁ; Department of Organic and Inorganic Chemistry, Federal University of Ceará, Fortaleza, Ceará, Brazil. Lima MAS; Department of Organic and Inorganic Chemistry, Federal University of Ceará, Fortaleza, Ceará, Brazil. Pimenta ATA; Department of Organic and Inorganic Chemistry, Federal University of Ceará, Fortaleza, Ceará, Brazil. Montenegro RC; Drug Research and Development Center (NPDM), Federal University of Ceará, Fortaleza, Ceará, Brazil. deMoraesMEA; Drug Research and Development Center (NPDM), Federal University of Ceará, Fortaleza, Ceará, Brazil. Pinto VPT; School of Medicine, Federal University of Ceará, Sobral, Ceará, Brazil. Filho GC; School of Medicine, Federal University of Ceará, Sobral, Ceará, Brazil. Bezerra MM; School of Medicine, Federal University of Ceará, Sobral, Ceará, Brazil.; Drug Research and Development Center (NPDM), Federal University of Ceará, Fortaleza, Ceará, Brazil.
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Źródło :
PloS one [PLoS One] 2019 Nov 04; Vol. 14 (11), pp. e0223800. Date of Electronic Publication: 2019 Nov 04 (Print Publication: 2019).
Characterization of Telomerase ( hTERT ) in Solid and Hematopoietic Cancer Cell Lines Reveals Different Expression Patterns.
Autorzy :
DE Holanda LS; Unichristus University Center, Faculty of Biomedicine, Fortaleza, Brazil. Mesquita FP; Pharmacogenetics Laboratory, Drug Research and Development Center (NPDM), Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, Brazil. DEMoraes-Filho MO; Pharmacogenetics Laboratory, Drug Research and Development Center (NPDM), Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, Brazil. DEMoraesMEA; Pharmacogenetics Laboratory, Drug Research and Development Center (NPDM), Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, Brazil. Montenegro RC; Pharmacogenetics Laboratory, Drug Research and Development Center (NPDM), Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, Brazil. DE Sousa Portilho AJ; Pharmacogenetics Laboratory, Drug Research and Development Center (NPDM), Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, Brazil. Moreira-Nunes CA; Unichristus University Center, Faculty of Biomedicine, Fortaleza, Brazil .; Pharmacogenetics Laboratory, Drug Research and Development Center (NPDM), Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, Brazil.
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