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Wyświetlanie 1-16 z 16
Tytuł:
PARP1 Characterization as a Potential Biomarker for BCR::ABL1 p190+ Acute Lymphoblastic Leukemia.
Autorzy:
Machado CB; Department of Medicine, Pharmacogenetics Laboratory, Drug Research and Development Center (NPDM), Federal University of Ceará, Fortaleza 60430-275, CE, Brazil.
da Silva EL; Department of Medicine, Pharmacogenetics Laboratory, Drug Research and Development Center (NPDM), Federal University of Ceará, Fortaleza 60430-275, CE, Brazil.
Ferreira WAS; Laboratory of Cytogenomics and Environmental Mutagenesis, Environment Section (SAMAM), Evandro Chagas Institute (IEC), Ananindeua 67030-000, PA, Brazil.
Pessoa FMCP; Department of Medicine, Pharmacogenetics Laboratory, Drug Research and Development Center (NPDM), Federal University of Ceará, Fortaleza 60430-275, CE, Brazil.
de Quadros AU; Center for Cell-Based Therapy, Regional Blood Center of Ribeirão Preto, University of São Paulo, Ribeirão Preto 14051-140, SP, Brazil.
Fantacini DMC; Center for Cell-Based Therapy, Regional Blood Center of Ribeirão Preto, University of São Paulo, Ribeirão Preto 14051-140, SP, Brazil.
Furtado IP; Center for Cell-Based Therapy, Regional Blood Center of Ribeirão Preto, University of São Paulo, Ribeirão Preto 14051-140, SP, Brazil.
Rossetti R; Center for Cell-Based Therapy, Regional Blood Center of Ribeirão Preto, University of São Paulo, Ribeirão Preto 14051-140, SP, Brazil.
Silveira RM; Center for Cell-Based Therapy, Regional Blood Center of Ribeirão Preto, University of São Paulo, Ribeirão Preto 14051-140, SP, Brazil.
de Lima SCG; Center for Cell-Based Therapy, Regional Blood Center of Ribeirão Preto, University of São Paulo, Ribeirão Preto 14051-140, SP, Brazil.
Mello Júnior FAR; Molecular Biology Laboratory, Ophir Loyola Hospital, Belém 66063-240, PA, Brazil.
Seabra AD; Molecular Biology Laboratory, Ophir Loyola Hospital, Belém 66063-240, PA, Brazil.
Moreira ECO; Institute of Health and Biological Studies, Federal University of the South and Southeast of Pará, Marabá 68501-970, PA, Brazil.
de Moraes Filho MO; Department of Medicine, Pharmacogenetics Laboratory, Drug Research and Development Center (NPDM), Federal University of Ceará, Fortaleza 60430-275, CE, Brazil.
de Moraes MEA; Department of Medicine, Pharmacogenetics Laboratory, Drug Research and Development Center (NPDM), Federal University of Ceará, Fortaleza 60430-275, CE, Brazil.
Montenegro RC; Department of Medicine, Pharmacogenetics Laboratory, Drug Research and Development Center (NPDM), Federal University of Ceará, Fortaleza 60430-275, CE, Brazil.
Ribeiro RM; Department of Hematology, Fortaleza General Hospital (HGF), Fortaleza 60150-160, CE, Brazil.
Khayat AS; Department of Biological Sciences, Oncology Research Center, Federal University of Pará, Belém 66073-005, PA, Brazil.
Burbano RMR; Molecular Biology Laboratory, Ophir Loyola Hospital, Belém 66063-240, PA, Brazil.; Department of Biological Sciences, Oncology Research Center, Federal University of Pará, Belém 66073-005, PA, Brazil.
de Oliveira EHC; Laboratory of Cytogenomics and Environmental Mutagenesis, Environment Section (SAMAM), Evandro Chagas Institute (IEC), Ananindeua 67030-000, PA, Brazil.
Covas DT; Center for Cell-Based Therapy, Regional Blood Center of Ribeirão Preto, University of São Paulo, Ribeirão Preto 14051-140, SP, Brazil.
de Souza LEB; Center for Cell-Based Therapy, Regional Blood Center of Ribeirão Preto, University of São Paulo, Ribeirão Preto 14051-140, SP, Brazil.
Moreira-Nunes CFA; Department of Medicine, Pharmacogenetics Laboratory, Drug Research and Development Center (NPDM), Federal University of Ceará, Fortaleza 60430-275, CE, Brazil.; Department of Biological Sciences, Oncology Research Center, Federal University of Pará, Belém 66073-005, PA, Brazil.; Northeast Biotechnology Network (RENORBIO), Itaperi Campus, Ceará State University, Fortaleza 60740-903, CE, Brazil.
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Źródło:
Cancers [Cancers (Basel)] 2023 Nov 22; Vol. 15 (23). Date of Electronic Publication: 2023 Nov 22.
Typ publikacji:
Journal Article
Czasopismo naukowe
Tytuł:
A Shortcut from Genome to Drug: The Employment of Bioinformatic Tools to Find New Targets for Gastric Cancer Treatment.
Autorzy:
Brito DMS; Department of Biochemistry and Molecular Biology, Federal University of Ceará, Fortaleza 60020-181, Brazil.; Pharmacogenetics Laboratory, Drug Research and Development Center, Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza 60430-160, Brazil.
Lima OG; Pharmacogenetics Laboratory, Drug Research and Development Center, Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza 60430-160, Brazil.
Mesquita FP; Pharmacogenetics Laboratory, Drug Research and Development Center, Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza 60430-160, Brazil.
da Silva EL; Pharmacogenetics Laboratory, Drug Research and Development Center, Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza 60430-160, Brazil.
de Moraes MEA; Pharmacogenetics Laboratory, Drug Research and Development Center, Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza 60430-160, Brazil.
Burbano RMR; Department of Biological Sciences, Oncology Research Center, Federal University of Pará, Belém 66073-005, Brazil.; Molecular Biology Laboratory, Ophir Loyola Hospital, Belém 66063-240, Brazil.
Montenegro RC; Pharmacogenetics Laboratory, Drug Research and Development Center, Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza 60430-160, Brazil.; Red Latinoamericana de Implementación y Validación de Guias Clinicas Farmacogenomicas (RELIVAF), Cyted, 28015 Madrid, Spain.
Souza PFN; Department of Biochemistry and Molecular Biology, Federal University of Ceará, Fortaleza 60020-181, Brazil.; Pharmacogenetics Laboratory, Drug Research and Development Center, Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza 60430-160, Brazil.
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Źródło:
Pharmaceutics [Pharmaceutics] 2023 Sep 12; Vol. 15 (9). Date of Electronic Publication: 2023 Sep 12.
Typ publikacji:
Journal Article
Czasopismo naukowe
Tytuł:
Kinase Inhibitor Screening Displayed ALK as a Possible Therapeutic Biomarker for Gastric Cancer.
Autorzy:
Mesquita FP; Department of Medicine, Pharmacogenetics Laboratory, Drug Research and Development Center (NPDM), Federal University of Ceará, Fortaleza 60430-275, CE, Brazil.
Souza PFN; Department of Medicine, Pharmacogenetics Laboratory, Drug Research and Development Center (NPDM), Federal University of Ceará, Fortaleza 60430-275, CE, Brazil.; Department of Biochemistry and Molecular Biology, Federal University of Ceará, Fortaleza 60430-275, CE, Brazil.
da Silva EL; Department of Medicine, Pharmacogenetics Laboratory, Drug Research and Development Center (NPDM), Federal University of Ceará, Fortaleza 60430-275, CE, Brazil.
Lima LB; Department of Medicine, Pharmacogenetics Laboratory, Drug Research and Development Center (NPDM), Federal University of Ceará, Fortaleza 60430-275, CE, Brazil.
de Oliveira LLB; Department of Medicine, Pharmacogenetics Laboratory, Drug Research and Development Center (NPDM), Federal University of Ceará, Fortaleza 60430-275, CE, Brazil.
Moreira-Nunes CA; Department of Medicine, Pharmacogenetics Laboratory, Drug Research and Development Center (NPDM), Federal University of Ceará, Fortaleza 60430-275, CE, Brazil.; Department of Biological Sciences, Oncology Research Center, Federal University of Pará, Belém 66073-005, PA, Brazil.
Zuercher WJ; Division of Chemical Biology and Medicinal Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Burbano RMR; Department of Biological Sciences, Oncology Research Center, Federal University of Pará, Belém 66073-005, PA, Brazil.; Laboratory of Human Cytogenetics, Institute of Biological Sciences, Federal University of Pará, Belém 66073-005, PA, Brazil.; Molecular Biology Laboratory, Ophir Loyola Hospital, Belém 66073-005, PA, Brazil.
de Moraes MEA; Department of Medicine, Pharmacogenetics Laboratory, Drug Research and Development Center (NPDM), Federal University of Ceará, Fortaleza 60430-275, CE, Brazil.
Montenegro RC; Department of Medicine, Pharmacogenetics Laboratory, Drug Research and Development Center (NPDM), Federal University of Ceará, Fortaleza 60430-275, CE, Brazil.
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Źródło:
Pharmaceutics [Pharmaceutics] 2022 Sep 01; Vol. 14 (9). Date of Electronic Publication: 2022 Sep 01.
Typ publikacji:
Journal Article
Czasopismo naukowe
Tytuł:
Kinase Inhibition in Multiple Myeloma: Current Scenario and Clinical Perspectives.
Autorzy:
Barreto IV; Pharmacogenetics Laboratory, Department of Medicine, Drug Research and Development Center (NPDM), Federal University of Ceará, Fortaleza 60430-275, CE, Brazil.
Machado CB; Pharmacogenetics Laboratory, Department of Medicine, Drug Research and Development Center (NPDM), Federal University of Ceará, Fortaleza 60430-275, CE, Brazil.
Almeida DB; Unichristus University Center, Faculty of Biomedicine, Fortaleza 60430-275, CE, Brazil.
Pessoa FMCP; Pharmacogenetics Laboratory, Department of Medicine, Drug Research and Development Center (NPDM), Federal University of Ceará, Fortaleza 60430-275, CE, Brazil.
Gadelha RB; Pharmacogenetics Laboratory, Department of Medicine, Drug Research and Development Center (NPDM), Federal University of Ceará, Fortaleza 60430-275, CE, Brazil.
Pantoja LDC; Department of Biological Sciences, Oncology Research Center, Federal University of Pará, Belém 66073-005, PA, Brazil.
Oliveira DS; Department of Hematology, Fortaleza General Hospital (HGF), Fortaleza 60150-160, CE, Brazil.
Ribeiro RM; Department of Hematology, Fortaleza General Hospital (HGF), Fortaleza 60150-160, CE, Brazil.
Lopes GS; Department of Hematology, César Cals General Hospital, Fortaleza 60015-152, CE, Brazil.
de Moraes Filho MO; Pharmacogenetics Laboratory, Department of Medicine, Drug Research and Development Center (NPDM), Federal University of Ceará, Fortaleza 60430-275, CE, Brazil.
de Moraes MEA; Pharmacogenetics Laboratory, Department of Medicine, Drug Research and Development Center (NPDM), Federal University of Ceará, Fortaleza 60430-275, CE, Brazil.
Khayat AS; Department of Biological Sciences, Oncology Research Center, Federal University of Pará, Belém 66073-005, PA, Brazil.
de Oliveira EHC; Faculty of Natural Sciences, Institute of Exact and Natural Sciences, Federal University of Pará (UFPA), Rua Augusto Correa, 01, Belém 66075-990, PA, Brazil.; Laboratory of Cytogenomics and Environmental Mutagenesis, Environment Section (SAMAM), Evandro Chagas Institute (IEC), BR 316, KM 7, s/n, Levilândia, Ananindeua 67030-000, PA, Brazil.
Moreira-Nunes CA; Pharmacogenetics Laboratory, Department of Medicine, Drug Research and Development Center (NPDM), Federal University of Ceará, Fortaleza 60430-275, CE, Brazil.; Department of Biological Sciences, Oncology Research Center, Federal University of Pará, Belém 66073-005, PA, Brazil.; Northeast Biotechnology Network (RENORBIO), Itaperi Campus, Ceará State University, Fortaleza 60740-903, CE, Brazil.
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Źródło:
Pharmaceutics [Pharmaceutics] 2022 Aug 25; Vol. 14 (9). Date of Electronic Publication: 2022 Aug 25.
Typ publikacji:
Journal Article; Review
Czasopismo naukowe
Tytuł:
Circadian Rhythm Dysregulation and Leukemia Development: The Role of Clock Genes as Promising Biomarkers.
Autorzy:
Sanford ABA; Unichristus University Center, Faculty of Biomedicine, Fortaleza 60430-275, CE, Brazil.
da Cunha LS; Unichristus University Center, Faculty of Biomedicine, Fortaleza 60430-275, CE, Brazil.
Machado CB; Pharmacogenetics Laboratory, Department of Medicine, Drug Research and Development Center (NPDM), Federal University of Ceará, Fortaleza 60430-275, CE, Brazil.
de Pinho Pessoa FMC; Pharmacogenetics Laboratory, Department of Medicine, Drug Research and Development Center (NPDM), Federal University of Ceará, Fortaleza 60430-275, CE, Brazil.
Silva ANDS; Department of Biological Sciences, Oncology Research Center, Federal University of Pará, Belém 66073-005, PA, Brazil.
Ribeiro RM; Department of Hematology, Fortaleza General Hospital (HGF), Fortaleza 60150-160, CE, Brazil.
Moreira FC; Department of Biological Sciences, Oncology Research Center, Federal University of Pará, Belém 66073-005, PA, Brazil.
de Moraes Filho MO; Pharmacogenetics Laboratory, Department of Medicine, Drug Research and Development Center (NPDM), Federal University of Ceará, Fortaleza 60430-275, CE, Brazil.
de Moraes MEA; Pharmacogenetics Laboratory, Department of Medicine, Drug Research and Development Center (NPDM), Federal University of Ceará, Fortaleza 60430-275, CE, Brazil.
de Souza LEB; Center for Cell-Based Therapy, Regional Blood Center of Ribeirão Preto, University of São Paulo, São Paulo 14051-140, SP, Brazil.
Khayat AS; Department of Biological Sciences, Oncology Research Center, Federal University of Pará, Belém 66073-005, PA, Brazil.
Moreira-Nunes CA; Unichristus University Center, Faculty of Biomedicine, Fortaleza 60430-275, CE, Brazil.; Pharmacogenetics Laboratory, Department of Medicine, Drug Research and Development Center (NPDM), Federal University of Ceará, Fortaleza 60430-275, CE, Brazil.; Department of Biological Sciences, Oncology Research Center, Federal University of Pará, Belém 66073-005, PA, Brazil.; Northeast Biotechnology Network (RENORBIO), Itaperi Campus, Ceará State University, Fortaleza 60740-903, CE, Brazil.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Jul 26; Vol. 23 (15). Date of Electronic Publication: 2022 Jul 26.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Chronobiology Disorders*
Circadian Clocks*/genetics
Leukemia*/genetics
Neoplasms*
Biomarkers ; Circadian Rhythm/genetics ; Humans
Czasopismo naukowe
Tytuł:
1,4-Naphthoquinone (CNN1) Induces Apoptosis through DNA Damage and Promotes Upregulation of H2AFX in Leukemia Multidrug Resistant Cell Line.
Autorzy:
de Sousa Portilho AJ; Pharmacogenetics Laboratory, Drug Research and Development Center (NPDM), Federal University of Ceará, Fortaleza 60430-275, CE, Brazil.
da Silva EL; Pharmacogenetics Laboratory, Drug Research and Development Center (NPDM), Federal University of Ceará, Fortaleza 60430-275, CE, Brazil.
Bezerra ECA; Pharmacogenetics Laboratory, Drug Research and Development Center (NPDM), Federal University of Ceará, Fortaleza 60430-275, CE, Brazil.
Moraes Rego Gomes CBS; Institute of Chemistry, Federal University Fluminense, São João Batista St., 188-Niterói, Rio de Janeiro 24220-900, RJ, Brazil.
Ferreira V; Institute of Chemistry, Federal University Fluminense, São João Batista St., 188-Niterói, Rio de Janeiro 24220-900, RJ, Brazil.
de Moraes MEA; Pharmacogenetics Laboratory, Drug Research and Development Center (NPDM), Federal University of Ceará, Fortaleza 60430-275, CE, Brazil.
da Rocha DR; Institute of Chemistry, Federal University Fluminense, São João Batista St., 188-Niterói, Rio de Janeiro 24220-900, RJ, Brazil.
Burbano RMR; Department of Biological Sciences, Oncology Research Center, Federal University of Pará, Belém 66073-005, PA, Brazil.
Moreira-Nunes CA; Pharmacogenetics Laboratory, Drug Research and Development Center (NPDM), Federal University of Ceará, Fortaleza 60430-275, CE, Brazil.; Department of Biological Sciences, Oncology Research Center, Federal University of Pará, Belém 66073-005, PA, Brazil.
Montenegro RC; Pharmacogenetics Laboratory, Drug Research and Development Center (NPDM), Federal University of Ceará, Fortaleza 60430-275, CE, Brazil.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Jul 23; Vol. 23 (15). Date of Electronic Publication: 2022 Jul 23.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents*/pharmacology
Antineoplastic Agents*/therapeutic use
Leukemia, Myelogenous, Chronic, BCR-ABL Positive*/drug therapy
Leukemia, Myelogenous, Chronic, BCR-ABL Positive*/genetics
Leukemia, Myelogenous, Chronic, BCR-ABL Positive*/metabolism
Leukemia, Myeloid*/drug therapy
Naphthoquinones*/pharmacology
Apoptosis ; Cell Line, Tumor ; DNA Damage ; Drug Resistance, Neoplasm/genetics ; Humans ; Leukocytes, Mononuclear/metabolism ; Up-Regulation
Czasopismo naukowe
Tytuł:
Role of miRNAs in Human T Cell Leukemia Virus Type 1 Induced T Cell Leukemia: A Literature Review and Bioinformatics Approach.
Autorzy:
Machado CB; Department of Medicine, Pharmacogenetics Laboratory, Drug Research and Development Center (NPDM), Federal University of Ceará, Fortaleza 60430-275, CE, Brazil.
da Cunha LS; Unichristus University Center, Faculty of Biomedicine, Fortaleza 60430-275, CE, Brazil.
Maués JHDS; Hematology and Transfusion Medicine Center, University of Campinas, Campinas 13083-970, SP, Brazil.
Pessoa FMCP; Department of Medicine, Pharmacogenetics Laboratory, Drug Research and Development Center (NPDM), Federal University of Ceará, Fortaleza 60430-275, CE, Brazil.
de Oliveira MB; Department of Biological Sciences, Oncology Research Center, Federal University of Pará, Belém 66073-005, PA, Brazil.
Ribeiro RM; Department of Hematology, Fortaleza General Hospital (HGF), Fortaleza 60150-160, CE, Brazil.
Lopes GS; Department of Hematology, César Cals General Hospital, Fortaleza 60015-152, CE, Brazil.
de Moraes Filho MO; Department of Medicine, Pharmacogenetics Laboratory, Drug Research and Development Center (NPDM), Federal University of Ceará, Fortaleza 60430-275, CE, Brazil.
de Moraes MEA; Department of Medicine, Pharmacogenetics Laboratory, Drug Research and Development Center (NPDM), Federal University of Ceará, Fortaleza 60430-275, CE, Brazil.
Khayat AS; Department of Biological Sciences, Oncology Research Center, Federal University of Pará, Belém 66073-005, PA, Brazil.
Moreira-Nunes CA; Department of Medicine, Pharmacogenetics Laboratory, Drug Research and Development Center (NPDM), Federal University of Ceará, Fortaleza 60430-275, CE, Brazil.; Unichristus University Center, Faculty of Biomedicine, Fortaleza 60430-275, CE, Brazil.; Department of Biological Sciences, Oncology Research Center, Federal University of Pará, Belém 66073-005, PA, Brazil.; Department of Health Sciences, Northeast Biotechnology Network (RENORBIO), Itaperi Campus, Ceará State University, Fortaleza 60740-903, CE, Brazil.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 May 14; Vol. 23 (10). Date of Electronic Publication: 2022 May 14.
Typ publikacji:
Journal Article; Review
MeSH Terms:
HTLV-I Infections*/genetics
Leukemia-Lymphoma, Adult T-Cell*/genetics
Leukemia-Lymphoma, Adult T-Cell*/virology
MicroRNAs*/genetics
Computational Biology ; Human T-lymphotropic virus 1 ; Humans
Czasopismo naukowe
Tytuł:
Solid Tumors and Kinase Inhibition: Management and Therapy Efficacy Evolution.
Autorzy:
de Pinho Pessoa FMC; Department of Medicine, Pharmacogenetics Laboratory, Drug Research and Development Center (NPDM), Federal University of Ceará, Fortaleza 60430-275, Brazil.
Machado CB; Department of Medicine, Pharmacogenetics Laboratory, Drug Research and Development Center (NPDM), Federal University of Ceará, Fortaleza 60430-275, Brazil.
da Silva EL; Department of Medicine, Pharmacogenetics Laboratory, Drug Research and Development Center (NPDM), Federal University of Ceará, Fortaleza 60430-275, Brazil.
da Costa Pantoja L; Department of Pediatrics, Octávio Lobo Children's Hospital, Belém 60430-275, Brazil.; Department of Biological Sciences, Oncology Research Center, Federal University of Pará, Belém 66073-005, Brazil.
Ribeiro RM; Department of Hematology, Fortaleza General Hospital (HGF), Fortaleza 60150-160, Brazil.
de Moraes MEA; Department of Medicine, Pharmacogenetics Laboratory, Drug Research and Development Center (NPDM), Federal University of Ceará, Fortaleza 60430-275, Brazil.
de Moraes Filho MO; Department of Medicine, Pharmacogenetics Laboratory, Drug Research and Development Center (NPDM), Federal University of Ceará, Fortaleza 60430-275, Brazil.
Montenegro RC; Department of Medicine, Pharmacogenetics Laboratory, Drug Research and Development Center (NPDM), Federal University of Ceará, Fortaleza 60430-275, Brazil.
Khayat AS; Department of Biological Sciences, Oncology Research Center, Federal University of Pará, Belém 66073-005, Brazil.
Moreira-Nunes CA; Department of Medicine, Pharmacogenetics Laboratory, Drug Research and Development Center (NPDM), Federal University of Ceará, Fortaleza 60430-275, Brazil.; Department of Biological Sciences, Oncology Research Center, Federal University of Pará, Belém 66073-005, Brazil.; Northeast Biotechnology Network (RENORBIO), Itaperi Campus, Ceará State University, Fortaleza 60740-903, Brazil.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Mar 30; Vol. 23 (7). Date of Electronic Publication: 2022 Mar 30.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Neoplasms*/drug therapy
Neoplasms*/pathology
Cytotoxins/therapeutic use ; Drug Delivery Systems ; Humans ; Immunologic Factors/therapeutic use ; Immunotherapy/methods ; Molecular Targeted Therapy
Czasopismo naukowe
Tytuł:
Kinase Inhibition in Relapsed/Refractory Leukemia and Lymphoma Settings: Recent Prospects into Clinical Investigations.
Autorzy:
Machado CB; Pharmacogenetics Laboratory, Drug Research and Development Center (NPDM), Department of Medicine, Federal University of Ceará, Fortaleza 60430-275, Brazil.
de Pinho Pessoa FMC; Pharmacogenetics Laboratory, Drug Research and Development Center (NPDM), Department of Medicine, Federal University of Ceará, Fortaleza 60430-275, Brazil.
da Silva EL; Pharmacogenetics Laboratory, Drug Research and Development Center (NPDM), Department of Medicine, Federal University of Ceará, Fortaleza 60430-275, Brazil.
da Costa Pantoja L; Department of Pediatrics, Octávio Lobo Children's Hospital, Belém 60430-275, Brazil.; Oncology Research Center, Department of Biological Sciences, Federal University of Pará, Belém 66073-005, Brazil.
Ribeiro RM; Department of Hematology, Fortaleza General Hospital (HGF), Fortaleza 60150-160, Brazil.
de Moraes Filho MO; Pharmacogenetics Laboratory, Drug Research and Development Center (NPDM), Department of Medicine, Federal University of Ceará, Fortaleza 60430-275, Brazil.
de Moraes MEA; Pharmacogenetics Laboratory, Drug Research and Development Center (NPDM), Department of Medicine, Federal University of Ceará, Fortaleza 60430-275, Brazil.
Montenegro RC; Pharmacogenetics Laboratory, Drug Research and Development Center (NPDM), Department of Medicine, Federal University of Ceará, Fortaleza 60430-275, Brazil.
Burbano RMR; Oncology Research Center, Department of Biological Sciences, Federal University of Pará, Belém 66073-005, Brazil.
Khayat AS; Oncology Research Center, Department of Biological Sciences, Federal University of Pará, Belém 66073-005, Brazil.
Moreira-Nunes CA; Pharmacogenetics Laboratory, Drug Research and Development Center (NPDM), Department of Medicine, Federal University of Ceará, Fortaleza 60430-275, Brazil.; Oncology Research Center, Department of Biological Sciences, Federal University of Pará, Belém 66073-005, Brazil.
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Źródło:
Pharmaceutics [Pharmaceutics] 2021 Oct 02; Vol. 13 (10). Date of Electronic Publication: 2021 Oct 02.
Typ publikacji:
Journal Article; Review
Czasopismo naukowe
Tytuł:
Targeting aurora kinases as a potential prognostic and therapeutical biomarkers in pediatric acute lymphoblastic leukaemia.
Autorzy:
Moreira-Nunes CA; Pharmacogenetics Laboratory, Drug Research and Development Center (NPDM), Federal University of Ceará, Coronel Nunes de Melo st, n 1000, Rodolfo Teófilo, Fortaleza, CE, CEP: 60416-000, Brazil. .
Mesquita FP; Pharmacogenetics Laboratory, Drug Research and Development Center (NPDM), Federal University of Ceará, Coronel Nunes de Melo st, n 1000, Rodolfo Teófilo, Fortaleza, CE, CEP: 60416-000, Brazil.
Portilho AJS; Pharmacogenetics Laboratory, Drug Research and Development Center (NPDM), Federal University of Ceará, Coronel Nunes de Melo st, n 1000, Rodolfo Teófilo, Fortaleza, CE, CEP: 60416-000, Brazil.
Mello Júnior FAR; Molecular Biology Laboratory, Ophir Loyola Hospital, Belém, PA, Brazil.
Maués JHDS; Laboratory of Human Cytogenetics, Institute of Biological Sciences, Federal University of Pará, Belém, PA, Brazil.
Pantoja LDC; Department of Pediatrics, Octávio Lobo Children's Hospital, Belém, PA, Brazil.
Wanderley AV; Department of Pediatrics, Octávio Lobo Children's Hospital, Belém, PA, Brazil.
Khayat AS; Oncology Research Center, João de Barros Barreto University Hospital, Federal University of Pará, Belém, PA, Brazil.
Zuercher WJ; Division of Chemical Biology and Medicinal Chemistry, University of North Carolina at Chapel Hill, Eshelman School of Pharmacy, Chapel Hill, NC, USA.
Montenegro RC; Pharmacogenetics Laboratory, Drug Research and Development Center (NPDM), Federal University of Ceará, Coronel Nunes de Melo st, n 1000, Rodolfo Teófilo, Fortaleza, CE, CEP: 60416-000, Brazil.
de Moraes-Filho MO; Pharmacogenetics Laboratory, Drug Research and Development Center (NPDM), Federal University of Ceará, Coronel Nunes de Melo st, n 1000, Rodolfo Teófilo, Fortaleza, CE, CEP: 60416-000, Brazil.
de Moraes MEA; Pharmacogenetics Laboratory, Drug Research and Development Center (NPDM), Federal University of Ceará, Coronel Nunes de Melo st, n 1000, Rodolfo Teófilo, Fortaleza, CE, CEP: 60416-000, Brazil.
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Źródło:
Scientific reports [Sci Rep] 2020 Dec 04; Vol. 10 (1), pp. 21272. Date of Electronic Publication: 2020 Dec 04.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Aurora Kinase A/*metabolism
Aurora Kinase B/*metabolism
Precursor Cell Lymphoblastic Leukemia-Lymphoma/*enzymology
Biomarkers, Tumor/metabolism ; Brazil/epidemiology ; Case-Control Studies ; Child ; Child, Preschool ; Female ; Fusion Proteins, bcr-abl/metabolism ; Humans ; Infant ; K562 Cells ; Male ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/genetics ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/mortality ; Protein Interaction Maps
Czasopismo naukowe
Tytuł:
Leu124Serfs*26, a novel AGPAT2 mutation in congenital generalized lipodystrophy with early cardiovascular complications.
Autorzy:
Montenegro Junior RM; 1Brazilian Group for the Study of Inherited and Acquired Lipodystrophies (BRAZLIPO), Faculdade de Medicina, Universidade Federal do Ceará, Rua Professor Costa Mendes, 1608, Rodolfo Teófilo, Fortaleza, Ceará 60416200 Brazil.
Lima GEDCP; 1Brazilian Group for the Study of Inherited and Acquired Lipodystrophies (BRAZLIPO), Faculdade de Medicina, Universidade Federal do Ceará, Rua Professor Costa Mendes, 1608, Rodolfo Teófilo, Fortaleza, Ceará 60416200 Brazil.
Fernandes VO; 1Brazilian Group for the Study of Inherited and Acquired Lipodystrophies (BRAZLIPO), Faculdade de Medicina, Universidade Federal do Ceará, Rua Professor Costa Mendes, 1608, Rodolfo Teófilo, Fortaleza, Ceará 60416200 Brazil.
Montenegro APDR; 1Brazilian Group for the Study of Inherited and Acquired Lipodystrophies (BRAZLIPO), Faculdade de Medicina, Universidade Federal do Ceará, Rua Professor Costa Mendes, 1608, Rodolfo Teófilo, Fortaleza, Ceará 60416200 Brazil.
Ponte CMM; 1Brazilian Group for the Study of Inherited and Acquired Lipodystrophies (BRAZLIPO), Faculdade de Medicina, Universidade Federal do Ceará, Rua Professor Costa Mendes, 1608, Rodolfo Teófilo, Fortaleza, Ceará 60416200 Brazil.
Martins LV; 1Brazilian Group for the Study of Inherited and Acquired Lipodystrophies (BRAZLIPO), Faculdade de Medicina, Universidade Federal do Ceará, Rua Professor Costa Mendes, 1608, Rodolfo Teófilo, Fortaleza, Ceará 60416200 Brazil.
Pinheiro DP; 2Drug Research and Development Center-NPDM, Universidade Federal do Ceará, Fortaleza, Brazil.
de Moraes MEA; 2Drug Research and Development Center-NPDM, Universidade Federal do Ceará, Fortaleza, Brazil.
de Moraes Filho MO; 2Drug Research and Development Center-NPDM, Universidade Federal do Ceará, Fortaleza, Brazil.
d'Alva CB; 1Brazilian Group for the Study of Inherited and Acquired Lipodystrophies (BRAZLIPO), Faculdade de Medicina, Universidade Federal do Ceará, Rua Professor Costa Mendes, 1608, Rodolfo Teófilo, Fortaleza, Ceará 60416200 Brazil.
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Źródło:
Diabetology & metabolic syndrome [Diabetol Metab Syndr] 2020 Apr 06; Vol. 12, pp. 28. Date of Electronic Publication: 2020 Apr 06 (Print Publication: 2020).
Typ publikacji:
Journal Article
Czasopismo naukowe
Tytuł:
Protective effect of Platymiscium floribundum Vog. in tree extract on periodontitis inflammation in rats.
Autorzy:
Freire JMO; Northeast Biotechnology Network-Ph.D. Program, Federal University of Ceará, Sobral, Ceará, Brazil.
Chaves HV; Northeast Biotechnology Network-Ph.D. Program, Federal University of Ceará, Sobral, Ceará, Brazil.
Teixeira AH; School of Dentistry, Federal University of Ceará, Sobral, Ceará, Brazil.
de Sousa LHT; Northeast Biotechnology Network-Ph.D. Program, Federal University of Ceará, Sobral, Ceará, Brazil.
Pinto IR; Northeast Biotechnology Network-Ph.D. Program, Federal University of Ceará, Sobral, Ceará, Brazil.
Costa JJDN; School of Medicine, University CenterINTA-UNINTA, Sobral, Ceará, Brazil.
de Sousa NA; School of Medicine, Federal University of Ceará, Sobral, Ceará, Brazil.
Pereira KMA; Department of Morphology, School of Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil.
Girão VCC; Department of Morphology, School of Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil.
Ferreira VCS; Postgraduate Program in Morphofunctional Sciences, Department of Morphology, School of Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil.
Dos Santos JEÁ; Department of Organic and Inorganic Chemistry, Federal University of Ceará, Fortaleza, Ceará, Brazil.
Lima MAS; Department of Organic and Inorganic Chemistry, Federal University of Ceará, Fortaleza, Ceará, Brazil.
Pimenta ATA; Department of Organic and Inorganic Chemistry, Federal University of Ceará, Fortaleza, Ceará, Brazil.
Montenegro RC; Drug Research and Development Center (NPDM), Federal University of Ceará, Fortaleza, Ceará, Brazil.
de Moraes MEA; Drug Research and Development Center (NPDM), Federal University of Ceará, Fortaleza, Ceará, Brazil.
Pinto VPT; School of Medicine, Federal University of Ceará, Sobral, Ceará, Brazil.
Filho GC; School of Medicine, Federal University of Ceará, Sobral, Ceará, Brazil.
Bezerra MM; School of Medicine, Federal University of Ceará, Sobral, Ceará, Brazil.; Drug Research and Development Center (NPDM), Federal University of Ceará, Fortaleza, Ceará, Brazil.
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Źródło:
PloS one [PLoS One] 2019 Nov 04; Vol. 14 (11), pp. e0223800. Date of Electronic Publication: 2019 Nov 04 (Print Publication: 2019).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Anti-Inflammatory Agents/*pharmacology
Inflammation/*drug therapy
Periodontitis/*drug therapy
Plant Extracts/*pharmacology
Protective Agents/*pharmacology
Trees/*chemistry
Animals ; Female ; Gingiva/drug effects ; Gingiva/metabolism ; Inflammation/metabolism ; Oxidative Stress/drug effects ; Periodontitis/metabolism ; Plant Leaves/chemistry ; Rats ; Rats, Wistar ; Transcription, Genetic/drug effects
Czasopismo naukowe
Tytuł:
Innovative treatment using tilapia skin as a xenograft for partial thickness burns after a gunpowder explosion.
Autorzy:
Lima-Junior EM; Burn Treatment Center, Dr. José Frota Institute, 60025-061, Fortaleza, CE, Brazil.
de Moraes Filho MO; Clinical Pharmacology Unit, Drug Research and Development Center, 60430-275, Federal University of Ceará (UFC), Fortaleza, CE, Brazil.
Costa BA; Clinical Pharmacology Unit, Drug Research and Development Center, 60430-275, Federal University of Ceará (UFC), Fortaleza, CE, Brazil.
Fechine FV; Clinical Pharmacology Unit, Drug Research and Development Center, 60430-275, Federal University of Ceará (UFC), Fortaleza, CE, Brazil.
de Moraes MEA; Clinical Pharmacology Unit, Drug Research and Development Center, 60430-275, Federal University of Ceará (UFC), Fortaleza, CE, Brazil.
Silva-Junior FR; Burn Treatment Center, Dr. José Frota Institute, 60025-061, Fortaleza, CE, Brazil.
Soares MFADN; Burn Treatment Center, Dr. José Frota Institute, 60025-061, Fortaleza, CE, Brazil.
Rocha MBS; Clinical Pharmacology Unit, Drug Research and Development Center, 60430-275, Federal University of Ceará (UFC), Fortaleza, CE, Brazil.
Leontsinis CMP; Burn Treatment Center, Dr. José Frota Institute, 60025-061, Fortaleza, CE, Brazil.
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Źródło:
Journal of surgical case reports [J Surg Case Rep] 2019 Jun 14; Vol. 2019 (6), pp. rjz181. Date of Electronic Publication: 2019 Jun 14 (Print Publication: 2019).
Typ publikacji:
Case Reports
Raport
Tytuł:
Pharmacological effects of the isomeric mixture of alpha and beta amyrin from Protium heptaphyllum: a literature review.
Autorzy:
Nogueira AO; Drug Discovery and Developmente Center, Federal University of Ceara, St. Coronel Nunes de Melo, 1000, Rodolfo Teófilo, Fortaleza, Brazil, 60430-275.; Higher Institute of Biomedical Sciences, Av. Dr. Silas Munguba, 1700, Itaperi, Fortaleza, Brazil, 60741-000.
Oliveira YIS; Drug Discovery and Developmente Center, Federal University of Ceara, St. Coronel Nunes de Melo, 1000, Rodolfo Teófilo, Fortaleza, Brazil, 60430-275.
Adjafre BL; Higher Institute of Biomedical Sciences, Av. Dr. Silas Munguba, 1700, Itaperi, Fortaleza, Brazil, 60741-000.
de Moraes MEA; Drug Discovery and Developmente Center, Federal University of Ceara, St. Coronel Nunes de Melo, 1000, Rodolfo Teófilo, Fortaleza, Brazil, 60430-275.
Aragão GF; Drug Discovery and Developmente Center, Federal University of Ceara, St. Coronel Nunes de Melo, 1000, Rodolfo Teófilo, Fortaleza, Brazil, 60430-275.; Medicine Course, State University of Ceara, Av. Dr. Silas Munguba, 1700, Itaperi, Fortaleza, Brazil, 60741-000.
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Źródło:
Fundamental & clinical pharmacology [Fundam Clin Pharmacol] 2019 Feb; Vol. 33 (1), pp. 4-12. Date of Electronic Publication: 2018 Aug 05.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Burseraceae/*chemistry
Oleanolic Acid/*analogs & derivatives
Animals ; Humans ; Oleanolic Acid/chemistry ; Oleanolic Acid/isolation & purification ; Oleanolic Acid/pharmacology ; Phytotherapy/methods ; Resins, Plant/chemistry ; Stereoisomerism
Czasopismo naukowe
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