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Wyświetlanie 1-15 z 15
Tytuł:
2-Methoxyestradiol-3,17- O , O -bis-sulfamate (STX140) Inhibits Proliferation and Invasion via Senescence Pathway Induction in Human BRAFi-Resistant Melanoma Cells.
Autorzy:
Franco YA; Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, Avenida Professor Lineu Prestes, Butantã 05508-000, São Paulo, Brazil.
de Moraes MO Jr; Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, Avenida Professor Lineu Prestes, Butantã 05508-000, São Paulo, Brazil.
Carvalho LAC; Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, Avenida Professor Lineu Prestes, Butantã 05508-000, São Paulo, Brazil.
Dohle W; Medicinal Chemistry & Drug Discovery, Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK.
da Silva RO; Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, Avenida Professor Lineu Prestes, Butantã 05508-000, São Paulo, Brazil.
Noma IHY; Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, Avenida Professor Lineu Prestes, Butantã 05508-000, São Paulo, Brazil.
Lima K; Department of Pharmacology, Biomedical Sciences Institute, University of São Paulo, Avenida Professor Lineu Prestes, Butantã 05508-000, São Paulo, Brazil.
Potter BVL; Medicinal Chemistry & Drug Discovery, Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK.
Machado-Neto JA; Department of Pharmacology, Biomedical Sciences Institute, University of São Paulo, Avenida Professor Lineu Prestes, Butantã 05508-000, São Paulo, Brazil.
Maria-Engler SS; Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, Avenida Professor Lineu Prestes, Butantã 05508-000, São Paulo, Brazil.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Jul 11; Vol. 24 (14). Date of Electronic Publication: 2023 Jul 11.
Typ publikacji:
Journal Article
MeSH Terms:
Estrenes*/pharmacology
Melanoma*/drug therapy
Humans ; 2-Methoxyestradiol/pharmacology ; Cell Proliferation ; Cell Line, Tumor ; Apoptosis
Czasopismo naukowe
Tytuł:
Association of MICA and HLA-B alleles with leprosy in two endemic populations in Brazil.
Autorzy:
Jarduli LR; Department of Clinical Analysis and Biomedicine, Graduate Program in Biosciences and Physiopathology, State University of Maringá, Maringá, Brazil.
Alves HV; Department of Clinical Analysis and Biomedicine, Graduate Program in Biosciences and Physiopathology, State University of Maringá, Maringá, Brazil.
de Souza VH; Department of Clinical Analysis and Biomedicine, Graduate Program in Biosciences and Physiopathology, State University of Maringá, Maringá, Brazil.
Uaska Sartori PV; Graduate Program in Health Sciences, School of Medicine, Pontifícia Universidade Católica do Paraná, Curitiba, Brazil.
Fava VM; Infectious Diseases and Immunity in Global Health (IDIGH) Program at the Research Institute of the McGill University Health Centre (RI-MUHC), Montreal, QC, Canada.
de Souza FC; Lauro de Souza Lima Institute, Bauru, Brazil.
Marcos EVC; Lauro de Souza Lima Institute, Bauru, Brazil.
Pereira AC; Lauro de Souza Lima Institute, Bauru, Brazil.
Dias-Baptista IMF; Lauro de Souza Lima Institute, Bauru, Brazil.
Virmond MDCL; Lauro de Souza Lima Institute, Bauru, Brazil.
de Moraes MO; Oswaldo Cruz Institute, FIOCRUZ, Rio de Janeiro, Brazil.
Mira MT; Graduate Program in Health Sciences, School of Medicine, Pontifícia Universidade Católica do Paraná, Curitiba, Brazil.
Visentainer JEL; Graduate Program in Health Sciences, School of Medicine, Pontifícia Universidade Católica do Paraná, Curitiba, Brazil.; Department of Basic Health Sciences, State University of Maringá, Maringá, Brazil.
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Źródło:
International journal of immunogenetics [Int J Immunogenet] 2021 Feb; Vol. 48 (1), pp. 25-35. Date of Electronic Publication: 2020 Nov 05.
Typ publikacji:
Comparative Study; Journal Article
MeSH Terms:
HLA-B Antigens/*genetics
Histocompatibility Antigens Class I/*genetics
Leprosy/*immunology
3' Untranslated Regions/genetics ; 5' Untranslated Regions/genetics ; Adolescent ; Adult ; Alleles ; Brazil/epidemiology ; Case-Control Studies ; Child ; Endemic Diseases ; Ethnicity/genetics ; Exons/genetics ; Family Health ; Female ; Gene Frequency ; Genetic Predisposition to Disease ; Genotype ; Haplotypes/genetics ; Humans ; Leprosy/epidemiology ; Leprosy/genetics ; Linkage Disequilibrium ; Male ; Middle Aged ; Polymorphism, Single Nucleotide ; Protein Domains ; Young Adult
Czasopismo naukowe
Tytuł:
Evaluation of the cytotoxicity of structurally correlated p-menthane derivatives.
Autorzy:
Andrade LN; Departamento de Fisiologia, Universidade Federal de Sergipe, CEP 49100-000, São Cristóvão-SE, Brazil. .
Lima TC; Departamento de Fisiologia, Universidade Federal de Sergipe, CEP 49100-000, São Cristóvão-SE, Brazil. tam_.
Amaral RG; Departamento de Fisiologia, Universidade Federal de Sergipe, CEP 49100-000, São Cristóvão-SE, Brazil. .
Pessoa Cdo Ó; Departamento de Fisiologia e Farmacologia, Universidade Federal do Ceará, CEP 60430-270, Fortaleza-SE, Brazil.
Filho MO; Departamento de Fisiologia e Farmacologia, Universidade Federal do Ceará, CEP 60430-270, Fortaleza-SE, Brazil. .
Soares BM; Departamento de Fisiologia e Farmacologia, Universidade Federal do Ceará, CEP 60430-270, Fortaleza-SE, Brazil. .
Nascimento LG; Departamento de Ciências Farmacêuticas, Universidade Federal da Paraíba, CP 5009, CEP 58051-970, João Pessoa-PB, Brazil. .
Carvalho AA; Farmácia, Universidade Federal de Sergipe, CEP 58051-970, Lagarto-SE, Brazil. .
de Sousa DP; Departamento de Ciências Farmacêuticas, Universidade Federal da Paraíba, CP 5009, CEP 58051-970, João Pessoa-PB, Brazil. .
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2015 Jul 21; Vol. 20 (7), pp. 13264-80. Date of Electronic Publication: 2015 Jul 21.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antineoplastic Agents*/chemical synthesis
Antineoplastic Agents*/chemistry
Antineoplastic Agents*/pharmacology
Cytotoxins*/chemical synthesis
Cytotoxins*/chemistry
Cytotoxins*/pharmacology
Terpenes*/chemical synthesis
Terpenes*/chemistry
Terpenes*/pharmacology
Neoplasms/*drug therapy
Cell Line, Tumor ; Drug Screening Assays, Antitumor ; Humans ; Neoplasms/metabolism ; Neoplasms/pathology
Czasopismo naukowe
Tytuł:
Antifungal activity of naphthoquinoidal compounds in vitro against fluconazole-resistant strains of different Candida species: a special emphasis on mechanisms of action on Candida tropicalis.
Autorzy:
Neto JB; Department of Clinical and Toxicological Analysis, School of Pharmacy, Laboratory of Bioprospection and Experiments in Yeast (LABEL), Federal University of Ceará, Fortaleza, Ceará, Brazil.
da Silva CR; Department of Clinical and Toxicological Analysis, School of Pharmacy, Laboratory of Bioprospection and Experiments in Yeast (LABEL), Federal University of Ceará, Fortaleza, Ceará, Brazil; Department of Pathology and Legal Medicine, School of Medicine, Laboratory of Bioprospection and Experiments in Yeast (LABEL), Federal University of Ceará, Fortaleza, Ceará, Brazil.
Neta MA; Department of Clinical and Toxicological Analysis, School of Pharmacy, Laboratory of Bioprospection and Experiments in Yeast (LABEL), Federal University of Ceará, Fortaleza, Ceará, Brazil; Department of Pathology and Legal Medicine, School of Medicine, Laboratory of Bioprospection and Experiments in Yeast (LABEL), Federal University of Ceará, Fortaleza, Ceará, Brazil.
Campos RS; Department of Clinical and Toxicological Analysis, School of Pharmacy, Laboratory of Bioprospection and Experiments in Yeast (LABEL), Federal University of Ceará, Fortaleza, Ceará, Brazil; Department of Pathology and Legal Medicine, School of Medicine, Laboratory of Bioprospection and Experiments in Yeast (LABEL), Federal University of Ceará, Fortaleza, Ceará, Brazil.
Siebra JT; Department of Clinical and Toxicological Analysis, School of Pharmacy, Laboratory of Bioprospection and Experiments in Yeast (LABEL), Federal University of Ceará, Fortaleza, Ceará, Brazil.
Silva RA; Department of Clinical and Toxicological Analysis, School of Pharmacy, Laboratory of Bioprospection and Experiments in Yeast (LABEL), Federal University of Ceará, Fortaleza, Ceará, Brazil.
Gaspar DM; Department of Physiology and Pharmacology, Laboratory of Experimental Oncology, Federal University of Ceará, Fortaleza, Ceará, Brazil.
Magalhães HI; Department of Clinical and Toxicological Analysis, School of Pharmacy, Laboratory of Bioprospection and Experiments in Yeast (LABEL), Federal University of Ceará, Fortaleza, Ceará, Brazil; Department of Pharmaceutical Sciences, Center for Toxicological Assistance, University Federal of Paraíba, Paraíba, Brazil.
de Moraes MO; Department of Physiology and Pharmacology, Laboratory of Experimental Oncology, Federal University of Ceará, Fortaleza, Ceará, Brazil.
Lobo MD; Department of Biology, ScienceCenter, Molecular Genetics Laboratory, Federal University of Ceará, Ceará, Brazil.
Grangeiro TB; Department of Biology, ScienceCenter, Molecular Genetics Laboratory, Federal University of Ceará, Ceará, Brazil.
Carvalho TS; Natural Products Research Nucleus, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Diogo EB; Department of Chemistry, Institute of Exact Sciences, Laboratory of Synthetic and Heterocyclic Chemistry, Federal University of Minas Gerais, Minas Gerais, Brazil.
da Silva Júnior EN; Department of Chemistry, Institute of Exact Sciences, Laboratory of Synthetic and Heterocyclic Chemistry, Federal University of Minas Gerais, Minas Gerais, Brazil.
Rodrigues FA; Department of Physiology and Pharmacology, Laboratory of Experimental Oncology, Federal University of Ceará, Fortaleza, Ceará, Brazil.
Cavalcanti BC; Department of Pathology and Legal Medicine, School of Medicine, Laboratory of Bioprospection and Experiments in Yeast (LABEL), Federal University of Ceará, Fortaleza, Ceará, Brazil; Department of Physiology and Pharmacology, Laboratory of Experimental Oncology, Federal University of Ceará, Fortaleza, Ceará, Brazil.
Júnior HV; Department of Clinical and Toxicological Analysis, School of Pharmacy, Laboratory of Bioprospection and Experiments in Yeast (LABEL), Federal University of Ceará, Fortaleza, Ceará, Brazil; Department of Pathology and Legal Medicine, School of Medicine, Laboratory of Bioprospection and Experiments in Yeast (LABEL), Federal University of Ceará, Fortaleza, Ceará, Brazil; Department of Physiology and Pharmacology, Laboratory of Experimental Oncology, Federal University of Ceará, Fortaleza, Ceará, Brazil.
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Źródło:
PloS one [PLoS One] 2014 May 09; Vol. 9 (5), pp. e93698. Date of Electronic Publication: 2014 May 09 (Print Publication: 2014).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antifungal Agents/*pharmacology
Candida/*drug effects
Drug Resistance, Fungal/*drug effects
Fluconazole/*pharmacology
Naphthoquinones/*pharmacology
Animals ; Antifungal Agents/chemical synthesis ; Antifungal Agents/chemistry ; Candida/classification ; Candida/genetics ; Candida tropicalis/drug effects ; Candida tropicalis/genetics ; Candida tropicalis/metabolism ; Cell Line ; Cell Survival/drug effects ; DNA Damage ; DNA, Fungal/chemistry ; DNA, Fungal/genetics ; DNA, Fungal/metabolism ; DNA, Ribosomal Spacer/chemistry ; DNA, Ribosomal Spacer/genetics ; Fibroblasts/cytology ; Fibroblasts/drug effects ; Membrane Potential, Mitochondrial/drug effects ; Microbial Sensitivity Tests ; Models, Chemical ; Molecular Sequence Data ; Molecular Structure ; Naphthoquinones/chemical synthesis ; Naphthoquinones/chemistry ; Phosphatidylserines ; RNA, Ribosomal, 5.8S/genetics ; Reactive Oxygen Species/metabolism ; Sequence Analysis, DNA
Czasopismo naukowe
Tytuł:
Global pharmacogenomics: Impact of population diversity on the distribution of polymorphisms in the CYP2C cluster among Brazilians.
Autorzy:
Suarez-Kurtz G; Divisão de Farmacologia, Instituto Nacional do Câncer-INCA, Rio de Janeiro, Brazil. />Genro JP
de Moraes MO
Ojopi EB
Pena SD
Perini JA
Ribeiro-dos-Santos A
Romano-Silva MA
Santana I
Struchiner CJ
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Źródło:
The pharmacogenomics journal [Pharmacogenomics J] 2012 Jun; Vol. 12 (3), pp. 267-76. Date of Electronic Publication: 2010 Dec 21.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Polymorphism, Single Nucleotide*
Aryl Hydrocarbon Hydroxylases/*genetics
Black People/*genetics
Cytochrome P-450 Enzyme System/*genetics
Indians, South American/*genetics
White People/*genetics
Brazil/epidemiology ; Cluster Analysis ; Cytochrome P-450 CYP2C19 ; Cytochrome P-450 CYP2C8 ; Cytochrome P-450 CYP2C9 ; Gene Frequency ; Haplotypes ; Humans ; Odds Ratio
Czasopismo naukowe
Tytuł:
Influence of genomic ancestry on the distribution of SLCO1B1, SLCO1B3 and ABCB1 gene polymorphisms among Brazilians.
Autorzy:
Sortica Vde A; Genetics Department, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
Ojopi EB
Genro JP
Callegari-Jacques S
Ribeiro-Dos-Santos A
de Moraes MO
Romano-Silva MA
Pena SD
Suarez-Kurtz G
Hutz MH
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Źródło:
Basic & clinical pharmacology & toxicology [Basic Clin Pharmacol Toxicol] 2012 May; Vol. 110 (5), pp. 460-8. Date of Electronic Publication: 2011 Dec 29.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Genetics, Population*
Polymorphism, Single Nucleotide*
ATP Binding Cassette Transporter, Subfamily B, Member 1/*genetics
Organic Anion Transporters/*genetics
Organic Anion Transporters, Sodium-Independent/*genetics
Racial Groups/*genetics
ATP Binding Cassette Transporter, Subfamily B ; Brazil ; Cohort Studies ; Gene Frequency ; Haplotypes ; Humans ; Liver-Specific Organic Anion Transporter 1 ; Molecular Targeted Therapy ; Pharmacogenetics ; Solute Carrier Organic Anion Transporter Family Member 1B3
Czasopismo naukowe
Tytuł:
Antitumor activity of two derivatives from 2-acylamine-1, 4-naphthoquinone in mice bearing S180 tumor.
Autorzy:
Bezerra DP; Department of Physiology and Pharmacology, School of Medicine, Federal University of Ceará, P.O. Box 3157, 60430-270 Fortaleza, Ceará, Brazil.
Alves AP
de Alencar NM
Mesquita Rde O
Lima MW
Pessoa C
de Moraes MO
Lopes JN
Lopes NP
Costa-Lotufo LV
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Źródło:
Journal of experimental therapeutics & oncology [J Exp Ther Oncol] 2008; Vol. 7 (2), pp. 113-21.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Anilides/*pharmacology
Antineoplastic Agents/*pharmacology
Naphthoquinones/*pharmacology
Sarcoma 180/*drug therapy
Alanine Transaminase/blood ; Anilides/chemical synthesis ; Anilides/toxicity ; Animals ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/toxicity ; Aspartate Aminotransferases/blood ; Blood Cell Count ; Body Weight/drug effects ; Female ; Kidney/pathology ; Mice ; Naphthoquinones/chemical synthesis ; Naphthoquinones/toxicity ; Neoplasm Transplantation ; Organ Size/drug effects ; Sarcoma 180/pathology ; Urea/blood
Czasopismo naukowe
    Wyświetlanie 1-15 z 15

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