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Tytuł :
α-amyrin-loaded nanocapsules produce selective cytotoxic activity in leukemic cells.
Autorzy :
Neto SF; Laboratory of Innovation and Development in Pharmaceutical Technology (LIDETEF), Faculty of Pharmaceutical Sciences, Universidade Federal do Amazonas, Av. Rodrigo Octavio Ramos, 6200, Coroado, Manaus, AM CEP 69077-000, Brazil.
Prada AL; Laboratory of Innovation and Development in Pharmaceutical Technology (LIDETEF), Faculty of Pharmaceutical Sciences, Universidade Federal do Amazonas, Av. Rodrigo Octavio Ramos, 6200, Coroado, Manaus, AM CEP 69077-000, Brazil.
Achod LDR; Laboratory of Innovation and Development in Pharmaceutical Technology (LIDETEF), Faculty of Pharmaceutical Sciences, Universidade Federal do Amazonas, Av. Rodrigo Octavio Ramos, 6200, Coroado, Manaus, AM CEP 69077-000, Brazil.
Torquato HFV; Biochemistry Department, Universidade Federal de São Paulo, Rua Três de Maio 100, São Paulo, SP, CEP 04044-020, Brazil.
Lima CS; Biochemistry Department, Universidade Federal de São Paulo, Rua Três de Maio 100, São Paulo, SP, CEP 04044-020, Brazil.
Paredes-Gamero EJ; Biochemistry Department, Universidade Federal de São Paulo, Rua Três de Maio 100, São Paulo, SP, CEP 04044-020, Brazil; Pharmaceutical Sciences Post-Graduation Program, Faculty of Pharmacy, Food and Nutrition, Universidade Federal do Mato Grosso do Sul, Av. Costa e Silva, Pioneiros, Campo Grande, MS CEP 79070-900, Brazil.
Silva de Moraes MO; Thematic Microscopy and Nanotechnology Laboratory (LTMN), Instituto Nacional de Pesquisas da Amazônia (INPA), Av. Bem Te ví, 8-406. Petrópolis, Manaus, AM 69067-001, Brazil.
Lima ES; Laboratory of Innovation and Development in Pharmaceutical Technology (LIDETEF), Faculty of Pharmaceutical Sciences, Universidade Federal do Amazonas, Av. Rodrigo Octavio Ramos, 6200, Coroado, Manaus, AM CEP 69077-000, Brazil.
Sosa EH; Department of Biochemistry & Molecular Biology, Dalhousie University, Sir Charles Tupper Medical Building, 5850 College Street, Halifax, Nova Scotia B3H 4R2, Canada.
de Souza TP; Laboratory of Innovation and Development in Pharmaceutical Technology (LIDETEF), Faculty of Pharmaceutical Sciences, Universidade Federal do Amazonas, Av. Rodrigo Octavio Ramos, 6200, Coroado, Manaus, AM CEP 69077-000, Brazil.
Amado JRR; Laboratory of Pharmaceutical Technology (LTF), Faculty of Pharmacy, Food and Nutrition, Universidade Federal do Mato Grosso do Sul, Av. Costa e Silva, Pioneiros, Campo Grande, MS CEP 79070-900, Brazil. Electronic address: .
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Źródło :
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2021 Jul; Vol. 139, pp. 111656. Date of Electronic Publication: 2021 May 08.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Effect of Topical Instillation of Pegaptanib Sodium Upon Inflammatory Corneal Neovascularization in Rabbits.
Autorzy :
Andrade N; Research and Development Center for Medicines, Federal University of Ceara, Fortaleza, Ceará, Brazil.
Crispim Ribeiro J; Department of Ophthalmology, Christus University Center (Unichristus), Fortaleza, Ceará, Brazil.
Araújo E Silva PM; Department of Ophthalmology, Christus University Center (Unichristus), Fortaleza, Ceará, Brazil.
Savio D; Department of Ophthalmology, Christus University Center (Unichristus), Fortaleza, Ceará, Brazil.
Fechine FV; Research and Development Center for Medicines, Federal University of Ceara, Fortaleza, Ceará, Brazil.
de Moraes MO; Research and Development Center for Medicines, Federal University of Ceara, Fortaleza, Ceará, Brazil.
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Źródło :
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics [J Ocul Pharmacol Ther] 2021 Jun; Vol. 37 (5), pp. 277-283. Date of Electronic Publication: 2021 Apr 22.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Diazepam's antifungal activity in fluconazole-resistant Candida spp. and biofilm inhibition in C. albicans : evaluation of the relationship with the proteins ALS3 and SAP5.
Autorzy :
Juvêncio da Silva L; Drug Research and Development Center, Federal University of Ceará, Fortaleza, CE, Brazil.; School of Pharmacy, Laboratory for Bioprospection of Antimicrobial Molecules (LABIMAN), Federal University of Ceará, Fortaleza, CE, Brazil.
Dias Barroso FD; Drug Research and Development Center, Federal University of Ceará, Fortaleza, CE, Brazil.; School of Pharmacy, Laboratory for Bioprospection of Antimicrobial Molecules (LABIMAN), Federal University of Ceará, Fortaleza, CE, Brazil.
Vieira LS; Christus University Center (UNICHRISTUS), Fortaleza, CE, Brazil.
Carlos Mota DR; Christus University Center (UNICHRISTUS), Fortaleza, CE, Brazil.
da Silva Firmino BK; Christus University Center (UNICHRISTUS), Fortaleza, CE, Brazil.
Rocha da Silva C; Drug Research and Development Center, Federal University of Ceará, Fortaleza, CE, Brazil.; School of Pharmacy, Laboratory for Bioprospection of Antimicrobial Molecules (LABIMAN), Federal University of Ceará, Fortaleza, CE, Brazil.
de Farias Cabral VP; School of Pharmacy, Laboratory for Bioprospection of Antimicrobial Molecules (LABIMAN), Federal University of Ceará, Fortaleza, CE, Brazil.
Cândido TM; Drug Research and Development Center, Federal University of Ceará, Fortaleza, CE, Brazil.; School of Pharmacy, Laboratory for Bioprospection of Antimicrobial Molecules (LABIMAN), Federal University of Ceará, Fortaleza, CE, Brazil.
Sá LGDAV; Drug Research and Development Center, Federal University of Ceará, Fortaleza, CE, Brazil.; School of Pharmacy, Laboratory for Bioprospection of Antimicrobial Molecules (LABIMAN), Federal University of Ceará, Fortaleza, CE, Brazil.
Barbosa da Silva WM; Christus University Center (UNICHRISTUS), Fortaleza, CE, Brazil.
Silva J; Department of Chemistry, Group for Theoretical Chemistry and Electrochemistry (GQTE), State University of Ceará, Limoeiro do Norte, Ceará, Brazil.
Marinho ES; Department of Chemistry, Group for Theoretical Chemistry and Electrochemistry (GQTE), State University of Ceará, Limoeiro do Norte, Ceará, Brazil.
Cavalcanti BC; Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, CE, Brazil.; Drug Research and Development Center, Federal University of Ceará, Fortaleza, CE, Brazil.
de Moraes MO; Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, CE, Brazil.; Drug Research and Development Center, Federal University of Ceará, Fortaleza, CE, Brazil.
Júnior HVN; Drug Research and Development Center, Federal University of Ceará, Fortaleza, CE, Brazil.; School of Pharmacy, Laboratory for Bioprospection of Antimicrobial Molecules (LABIMAN), Federal University of Ceará, Fortaleza, CE, Brazil.
de Andrade Neto JB; School of Pharmacy, Laboratory for Bioprospection of Antimicrobial Molecules (LABIMAN), Federal University of Ceará, Fortaleza, CE, Brazil.; Christus University Center (UNICHRISTUS), Fortaleza, CE, Brazil.
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Źródło :
Journal of medical microbiology [J Med Microbiol] 2021 Mar; Vol. 70 (3). Date of Electronic Publication: 2021 Feb 09.
Typ publikacji :
Journal Article
MeSH Terms :
Antifungal Agents/*pharmacology
Biofilms/*drug effects
Candida/*drug effects
Diazepam/*pharmacology
Drug Resistance, Fungal/*drug effects
Aspartic Acid Endopeptidases/metabolism ; Candida/pathogenicity ; Fluconazole/pharmacology ; Fungal Proteins/metabolism
Czasopismo naukowe
Tytuł :
Diterpenoids from Leaves of Cultivated Plectranthus ornatus.
Autorzy :
Mesquita LSF; Departamento de Química Orgânica e Inorgânica, Universidade Federal do Ceará, Fortaleza-CE, Brazil.
Matos TS; Departamento de Química Orgânica e Inorgânica, Universidade Federal do Ceará, Fortaleza-CE, Brazil.
Ávila FDN; Departamento de Química Orgânica e Inorgânica, Universidade Federal do Ceará, Fortaleza-CE, Brazil.
Batista ADS; Departamento de Química Orgânica e Inorgânica, Universidade Federal do Ceará, Fortaleza-CE, Brazil.
Moura AF; Núcleo de Pesquisa e Desenvolvimento de Medicamentos, Universidade Federal do Ceará, Fortaleza-CE, Brazil.
de Moraes MO; Núcleo de Pesquisa e Desenvolvimento de Medicamentos, Universidade Federal do Ceará, Fortaleza-CE, Brazil.
da Silva MCM; Instituto Superior de Ciências Biomédicas, Universidade Estadual do Ceará, Fortaleza-CE, Brazil.
Ferreira TLA; Instituto Superior de Ciências Biomédicas, Universidade Estadual do Ceará, Fortaleza-CE, Brazil.
Nascimento NRF; Instituto Superior de Ciências Biomédicas, Universidade Estadual do Ceará, Fortaleza-CE, Brazil.
Monteiro NKV; Departamento de Química Analítica e Físico-Química, Universidade Federal do Ceará, Fortaleza-CE, Brazil.
Pessoa ODL; Departamento de Química Orgânica e Inorgânica, Universidade Federal do Ceará, Fortaleza-CE, Brazil.
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Źródło :
Planta medica [Planta Med] 2021 Feb; Vol. 87 (1-02), pp. 124-135. Date of Electronic Publication: 2020 Aug 03.
Typ publikacji :
Journal Article
MeSH Terms :
Plectranthus*
Animals ; Diterpenes/pharmacology ; Guinea Pigs ; Humans ; Molecular Structure ; Plant Extracts/pharmacology ; Plant Leaves
Czasopismo naukowe
Tytuł :
Association of MICA and HLA-B alleles with leprosy in two endemic populations in Brazil.
Autorzy :
Jarduli LR; Department of Clinical Analysis and Biomedicine, Graduate Program in Biosciences and Physiopathology, State University of Maringá, Maringá, Brazil.
Alves HV; Department of Clinical Analysis and Biomedicine, Graduate Program in Biosciences and Physiopathology, State University of Maringá, Maringá, Brazil.
de Souza VH; Department of Clinical Analysis and Biomedicine, Graduate Program in Biosciences and Physiopathology, State University of Maringá, Maringá, Brazil.
Uaska Sartori PV; Graduate Program in Health Sciences, School of Medicine, Pontifícia Universidade Católica do Paraná, Curitiba, Brazil.
Fava VM; Infectious Diseases and Immunity in Global Health (IDIGH) Program at the Research Institute of the McGill University Health Centre (RI-MUHC), Montreal, QC, Canada.
de Souza FC; Lauro de Souza Lima Institute, Bauru, Brazil.
Marcos EVC; Lauro de Souza Lima Institute, Bauru, Brazil.
Pereira AC; Lauro de Souza Lima Institute, Bauru, Brazil.
Dias-Baptista IMF; Lauro de Souza Lima Institute, Bauru, Brazil.
Virmond MDCL; Lauro de Souza Lima Institute, Bauru, Brazil.
de Moraes MO; Oswaldo Cruz Institute, FIOCRUZ, Rio de Janeiro, Brazil.
Mira MT; Graduate Program in Health Sciences, School of Medicine, Pontifícia Universidade Católica do Paraná, Curitiba, Brazil.
Visentainer JEL; Graduate Program in Health Sciences, School of Medicine, Pontifícia Universidade Católica do Paraná, Curitiba, Brazil.; Department of Basic Health Sciences, State University of Maringá, Maringá, Brazil.
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Źródło :
International journal of immunogenetics [Int J Immunogenet] 2021 Feb; Vol. 48 (1), pp. 25-35. Date of Electronic Publication: 2020 Nov 05.
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
HLA-B Antigens/*genetics
Histocompatibility Antigens Class I/*genetics
Leprosy/*immunology
3' Untranslated Regions/genetics ; 5' Untranslated Regions/genetics ; Adolescent ; Adult ; Alleles ; Brazil/epidemiology ; Case-Control Studies ; Child ; Endemic Diseases ; Ethnic Groups/genetics ; Exons/genetics ; Family Health ; Female ; Gene Frequency ; Genetic Predisposition to Disease ; Genotype ; Haplotypes/genetics ; Humans ; Leprosy/epidemiology ; Leprosy/genetics ; Linkage Disequilibrium ; Male ; Middle Aged ; Polymorphism, Single Nucleotide ; Protein Domains ; Young Adult
Czasopismo naukowe
Tytuł :
Development and in vitro evaluation of microparticles of fluoxetine in galactomannan against biofilms of S. aureus methicilin resistant.
Autorzy :
Josino MAA; Department of Clinical and Toxicological Analysis, School of Pharmacy, Laboratory of Bioprospection in Antimicrobial Molecules (LABIMAN), Federal University of Ceará, Fortaleza, CE, Brazil. Electronic address: .
Rocha da Silva C; Department of Clinical and Toxicological Analysis, School of Pharmacy, Laboratory of Bioprospection in Antimicrobial Molecules (LABIMAN), Federal University of Ceará, Fortaleza, CE, Brazil; Laboratory of Bioprospection in Antimicrobial Molecules (LABIMAN), Drug Research and Development Center, Federal University of Ceará, Fortaleza, CE, Brazil.
de Andrade Neto JB; Laboratory of Bioprospection in Antimicrobial Molecules (LABIMAN), Drug Research and Development Center, Federal University of Ceará, Fortaleza, CE, Brazil; Christus University Center (UNICHRISTUS), Fortaleza, CE, Brazil.
Barroso FDD; Laboratory of Bioprospection in Antimicrobial Molecules (LABIMAN), Drug Research and Development Center, Federal University of Ceará, Fortaleza, CE, Brazil.
Juvêncio da Silva L; Laboratory of Bioprospection in Antimicrobial Molecules (LABIMAN), Drug Research and Development Center, Federal University of Ceará, Fortaleza, CE, Brazil.
Cavalcanti BC; Drug Research and Development Center, Federal University of Ceará, Fortaleza, CE, Brazil.
de Moraes MO; Drug Research and Development Center, Federal University of Ceará, Fortaleza, CE, Brazil.
Brito DHA; Laboratory of Polymers and Materials Innovation, Department of Organic and Inorganic Chemistry, Sciences Center, Federal University of Ceará, Campus of Pici, 60455-760 Fortaleza, CE, Brazil.
Ricardo NMPS; Laboratory of Polymers and Materials Innovation, Department of Organic and Inorganic Chemistry, Sciences Center, Federal University of Ceará, Campus of Pici, 60455-760 Fortaleza, CE, Brazil.
Júnior HVN; Department of Clinical and Toxicological Analysis, School of Pharmacy, Laboratory of Bioprospection in Antimicrobial Molecules (LABIMAN), Federal University of Ceará, Fortaleza, CE, Brazil; Laboratory of Bioprospection in Antimicrobial Molecules (LABIMAN), Drug Research and Development Center, Federal University of Ceará, Fortaleza, CE, Brazil.
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Źródło :
Carbohydrate polymers [Carbohydr Polym] 2021 Jan 15; Vol. 252, pp. 117184. Date of Electronic Publication: 2020 Oct 05.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Repositioning*
Anti-Bacterial Agents/*pharmacology
Biofilms/*drug effects
Fluoxetine/*pharmacology
Methicillin-Resistant Staphylococcus aureus/*drug effects
Drug Carriers/chemistry ; Drug Liberation ; Mannans/chemistry ; Microbial Sensitivity Tests
Czasopismo naukowe
Tytuł :
Antifungal activity of etomidate against growing biofilms of fluconazole-resistant Candida spp. strains, binding to mannoproteins and molecular docking with the ALS3 protein.
Autorzy :
Gurgel do Amaral Valente Sá L; Drug Research and Development Center, Federal University of Ceará, Fortaleza, 60430-275, CE, Brazil.; Department of Clinical and Toxicological Analysis, School of Pharmacy, Laboratory of Bioprospection in Antimicrobial Molecules (LABIMAN), Federal University of Ceará, Fortaleza, 60430-170, CE, Brazil.
da Silva CR; Drug Research and Development Center, Federal University of Ceará, Fortaleza, 60430-275, CE, Brazil.; Department of Clinical and Toxicological Analysis, School of Pharmacy, Laboratory of Bioprospection in Antimicrobial Molecules (LABIMAN), Federal University of Ceará, Fortaleza, 60430-170, CE, Brazil.
Neto JBA; Drug Research and Development Center, Federal University of Ceará, Fortaleza, 60430-275, CE, Brazil.; Department of Clinical and Toxicological Analysis, School of Pharmacy, Laboratory of Bioprospection in Antimicrobial Molecules (LABIMAN), Federal University of Ceará, Fortaleza, 60430-170, CE, Brazil.
do Nascimento FBSA; Drug Research and Development Center, Federal University of Ceará, Fortaleza, 60430-275, CE, Brazil.; Department of Clinical and Toxicological Analysis, School of Pharmacy, Laboratory of Bioprospection in Antimicrobial Molecules (LABIMAN), Federal University of Ceará, Fortaleza, 60430-170, CE, Brazil.
Barroso FDD; Drug Research and Development Center, Federal University of Ceará, Fortaleza, 60430-275, CE, Brazil.; Department of Clinical and Toxicological Analysis, School of Pharmacy, Laboratory of Bioprospection in Antimicrobial Molecules (LABIMAN), Federal University of Ceará, Fortaleza, 60430-170, CE, Brazil.
da Silva LJ; Drug Research and Development Center, Federal University of Ceará, Fortaleza, 60430-275, CE, Brazil.; Department of Clinical and Toxicological Analysis, School of Pharmacy, Laboratory of Bioprospection in Antimicrobial Molecules (LABIMAN), Federal University of Ceará, Fortaleza, 60430-170, CE, Brazil.
Cabral VPF; Drug Research and Development Center, Federal University of Ceará, Fortaleza, 60430-275, CE, Brazil.; Department of Clinical and Toxicological Analysis, School of Pharmacy, Laboratory of Bioprospection in Antimicrobial Molecules (LABIMAN), Federal University of Ceará, Fortaleza, 60430-170, CE, Brazil.
Barbosa AD; Drug Research and Development Center, Federal University of Ceará, Fortaleza, 60430-275, CE, Brazil.; Department of Clinical and Toxicological Analysis, School of Pharmacy, Laboratory of Bioprospection in Antimicrobial Molecules (LABIMAN), Federal University of Ceará, Fortaleza, 60430-170, CE, Brazil.
Silva J; Department of Chemistry, Group of Theoretical Chemistry and Electrochemistry (GQTE), State University of Ceará, Limoeiro do Norte, 62930-000, CE, Brazil.
Marinho ES; Department of Chemistry, Group of Theoretical Chemistry and Electrochemistry (GQTE), State University of Ceará, Limoeiro do Norte, 62930-000, CE, Brazil.
de Moraes MO; Department of Physiology and Pharmacology, Neuropharmacology Laboratory, Federal University of Ceará, Fortaleza, 60430-275, CE, Brazil.
Rios MEF; Drug Research and Development Center, Federal University of Ceará, Fortaleza, 60430-275, CE, Brazil.
Cavalcanti BC; Drug Research and Development Center, Federal University of Ceará, Fortaleza, 60430-275, CE, Brazil.
Lima ISP; Departament of Pharmacology, School of Medicine, Federal University of Ceará, Barbalha, 63048-080, CE, Brazil.
Júnior HVN; Drug Research and Development Center, Federal University of Ceará, Fortaleza, 60430-275, CE, Brazil.
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Źródło :
Journal of medical microbiology [J Med Microbiol] 2020 Oct; Vol. 69 (10), pp. 1221-1227. Date of Electronic Publication: 2020 Sep 04.
Typ publikacji :
Journal Article
MeSH Terms :
Candida/*drug effects
Drug Resistance, Fungal/*drug effects
Etomidate/*pharmacology
Antifungal Agents/metabolism ; Antifungal Agents/pharmacology ; Biofilms/drug effects ; Candida albicans/drug effects ; Etomidate/metabolism ; Fluconazole/pharmacology ; Fungal Proteins/metabolism ; Humans ; Membrane Glycoproteins/metabolism ; Microbial Sensitivity Tests ; Molecular Docking Simulation/methods
Czasopismo naukowe
Tytuł :
Etomidate is devoid of genotoxicty and mutagenicity in human lymphocytes and in the Salmonella typhimurium/microsomal activation test.
Autorzy :
Cavalcanti BC; Drug Research and Development Center, Federal University of Ceará, Fortaleza, CE, Brazil; Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, CE, Brazil. Electronic address: .b.
do Amaral Valente Sá LG; Drug Research and Development Center, Federal University of Ceará, Fortaleza, CE, Brazil; School of Pharmacy, Laboratory for Bioprospection of Antimicrobial Molecules (LABIMAN), Federal University of Ceará, Fortaleza, CE, Brazil.
de Andrade Neto JB; Drug Research and Development Center, Federal University of Ceará, Fortaleza, CE, Brazil; Christus University Center (UNICHRISTUS), Fortaleza, CE, Brazil; School of Pharmacy, Laboratory for Bioprospection of Antimicrobial Molecules (LABIMAN), Federal University of Ceará, Fortaleza, CE, Brazil.
de Sousa Silva AA; Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, CE, Brazil.
Rios MEF; Drug Research and Development Center, Federal University of Ceará, Fortaleza, CE, Brazil.
Barreto FS; Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, CE, Brazil.
de Oliveira Ferreira JR; School of Medical Sciences, State University of Health Sciences of Alagoas (UNCISAL), AL, Brazil.
da Silva CR; Drug Research and Development Center, Federal University of Ceará, Fortaleza, CE, Brazil; School of Pharmacy, Laboratory for Bioprospection of Antimicrobial Molecules (LABIMAN), Federal University of Ceará, Fortaleza, CE, Brazil.
Barroso FD; School of Pharmacy, Laboratory for Bioprospection of Antimicrobial Molecules (LABIMAN), Federal University of Ceará, Fortaleza, CE, Brazil.
Magalhães HIF; Department of Pharmaceutical Sciences, Federal University of Paraiba, João Pessoa, PB, Brazil.
Nobre HV Jr; Drug Research and Development Center, Federal University of Ceará, Fortaleza, CE, Brazil; School of Pharmacy, Laboratory for Bioprospection of Antimicrobial Molecules (LABIMAN), Federal University of Ceará, Fortaleza, CE, Brazil.
de Moraes MO; Drug Research and Development Center, Federal University of Ceará, Fortaleza, CE, Brazil; Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, CE, Brazil.
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Źródło :
Toxicology in vitro : an international journal published in association with BIBRA [Toxicol In Vitro] 2020 Oct; Vol. 68, pp. 104946. Date of Electronic Publication: 2020 Jul 15.
Typ publikacji :
Journal Article
MeSH Terms :
Etomidate/*toxicity
Hypnotics and Sedatives/*toxicity
Lymphocytes/*drug effects
Salmonella typhimurium/*drug effects
Adult ; Animals ; Cell Survival/drug effects ; Cells, Cultured ; DNA Damage ; Erythrocytes/drug effects ; Hemolysis/drug effects ; Humans ; Lymphocytes/metabolism ; Mice ; Mutagenicity Tests ; Salmonella typhimurium/genetics ; Young Adult
Czasopismo naukowe
Tytuł :
Antifungal and antiprotozoal green amino acid-based rhamnolipids: Mode of action, antibiofilm efficiency and selective activity against resistant Candida spp. strains and Acanthamoeba castellanii.
Autorzy :
da Silva A; Department of Biology, Healthcare and the Environment, Section Microbiology, Faculty of Pharmacy, University of Barcelona, Barcelona, Spain.
Nobre H Jr; Laboratory of Bioprospection in Antimicrobial Molecules, Federal University of Ceará, Fortaleza, Brazil.
Sampaio L; Laboratory of Bioprospection in Antimicrobial Molecules, Federal University of Ceará, Fortaleza, Brazil.
Nascimento BD; Laboratory of Bioprospection in Antimicrobial Molecules, Federal University of Ceará, Fortaleza, Brazil.
da Silva C; Laboratory of Bioprospection in Antimicrobial Molecules, Federal University of Ceará, Fortaleza, Brazil.
de Andrade Neto JB; Laboratory of Bioprospection in Antimicrobial Molecules, Federal University of Ceará, Fortaleza, Brazil.
Manresa Á; Department of Biology, Healthcare and the Environment, Section Microbiology, Faculty of Pharmacy, University of Barcelona, Barcelona, Spain.
Pinazo A; Department of Surfactants and Nanobiotechnology, IQAC-CSIC, Barcelona, Spain.
Cavalcanti B; Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, Brazil.
de Moraes MO; Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, Brazil.
Ruiz-Trillo I; Institute of Evolutionary Biology (CSIC- Pompeu Fabra University), Barcelona, Spain; Department of Genetics, Microbiology and Statistics, University of Barcelona, ICREA, Barcelona, Spain.
Antó M; Institute of Evolutionary Biology (CSIC- Pompeu Fabra University), Barcelona, Spain.
Morán C; Department of Physiology, Faculty of Pharmacy, University of Barcelona, Barcelona, Spain.
Pérez L; Department of Surfactants and Nanobiotechnology, IQAC-CSIC, Barcelona, Spain. Electronic address: .
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Źródło :
Colloids and surfaces. B, Biointerfaces [Colloids Surf B Biointerfaces] 2020 Sep; Vol. 193, pp. 111148. Date of Electronic Publication: 2020 May 26.
Typ publikacji :
Journal Article
MeSH Terms :
Acanthamoeba castellanii/*drug effects
Amino Acids/*pharmacology
Antifungal Agents/*pharmacology
Antiprotozoal Agents/*pharmacology
Candida/*drug effects
Glycolipids/*pharmacology
Amino Acids/chemistry ; Antifungal Agents/chemistry ; Antiprotozoal Agents/chemistry ; Biofilms/drug effects ; Drug Resistance, Fungal/drug effects ; Glycolipids/chemistry ; Microbial Sensitivity Tests ; Molecular Conformation ; Parasitic Sensitivity Tests
Czasopismo naukowe
Tytuł :
Antitumor Potential of the Isoflavonoids (+)- and (-)-2,3,9-Trimethoxypterocarpan: Mechanism-of-Action Studies.
Autorzy :
Farias K; Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceará, Fortaleza, CE 60430-275, Brazil.
da Costa RF; Department of Natural Sciences, Mathematics and Statistics, Federal Rural University of the Semi-Arid Region - UFERSA, Mossoró - RN 59625-900, Brazil.
Meira AS; Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceará, Fortaleza, CE 60430-275, Brazil.
Diniz-Filho J; Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceará, Fortaleza, CE 60430-275, Brazil.
Bezerra EM; Department of Natural Sciences, Mathematics and Statistics, Federal Rural University of the Semi-Arid Region - UFERSA, Mossoró - RN 59625-900, Brazil.
Freire VN; Department of Physics, Science Center, Federal University of Ceará, Fortaleza, CE 60430-275, Brazil.
Guest P; Research School of Chemistry, Institute of Advanced Studies, The Australian National University, Canberra, ACT 2601, Australia.
Nikahd M; Research School of Chemistry, Institute of Advanced Studies, The Australian National University, Canberra, ACT 2601, Australia.
Ma X; Research School of Chemistry, Institute of Advanced Studies, The Australian National University, Canberra, ACT 2601, Australia.
Gardiner MG; Research School of Chemistry, Institute of Advanced Studies, The Australian National University, Canberra, ACT 2601, Australia.
Banwell MG; Research School of Chemistry, Institute of Advanced Studies, The Australian National University, Canberra, ACT 2601, Australia.; Institute for Advanced and Applied Chemical Synthesis, Jinan University, Guangzhou 510632, China.
de Oliveira MDCF; Department of Organic and Inorganic Chemistry, Science Center, Federal University of Ceará, Fortaleza, CE 60430-275, Brazil.
de Moraes MO; Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceará, Fortaleza, CE 60430-275, Brazil.
do Ó Pessoa C; Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceará, Fortaleza, CE 60430-275, Brazil.
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Źródło :
ACS medicinal chemistry letters [ACS Med Chem Lett] 2020 May 20; Vol. 11 (6), pp. 1274-1280. Date of Electronic Publication: 2020 May 20 (Print Publication: 2020).
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Evaluation of Genotoxicity and Mutagenicity of Ketamine on Human Peripheral Blood Leukocytes and in Salmonella typhimurium.
Autorzy :
Cavalcanti BC; Department of Physiology and Pharmacology, Federal University of Ceara, Fortaleza, CE, Brazil; Drug Research and Development Center, Federal University of Ceara, Fortaleza, CE, Brazil. Electronic address: .
de Andrade Neto JB; School of Pharmacy, Laboratory of Bioprospection in Antimicrobial Molecules (LABIMAN), Federal University of Ceara, Fortaleza, CE, Brazil; Christus University Center (UNICHRISTUS), Fortaleza, CE, Brazil; Drug Research and Development Center, Federal University of Ceara, Fortaleza, CE, Brazil.
de Sousa Silva AA; Drug Research and Development Center, Federal University of Ceara, Fortaleza, CE, Brazil.
Barreto FS; Drug Research and Development Center, Federal University of Ceara, Fortaleza, CE, Brazil.
de Oliveira Ferreira JR; School of Medical Sciences, State University of Health Sciences of Alagoas (UNCISAL), AL, Brazil.
da Silva CR; School of Pharmacy, Laboratory of Bioprospection in Antimicrobial Molecules (LABIMAN), Federal University of Ceara, Fortaleza, CE, Brazil; Drug Research and Development Center, Federal University of Ceara, Fortaleza, CE, Brazil.
Aires do Nascimento FBS; School of Pharmacy, Laboratory of Bioprospection in Antimicrobial Molecules (LABIMAN), Federal University of Ceara, Fortaleza, CE, Brazil; Drug Research and Development Center, Federal University of Ceara, Fortaleza, CE, Brazil.
do Amaral Valente Sá LG; School of Pharmacy, Laboratory of Bioprospection in Antimicrobial Molecules (LABIMAN), Federal University of Ceara, Fortaleza, CE, Brazil; Drug Research and Development Center, Federal University of Ceara, Fortaleza, CE, Brazil.
Magalhães HIF; Department of Pharmaceutical Sciences, Federal University of Paraiba, João Pessoa, PB, Brazil.
Nobre Júnior HV; School of Pharmacy, Laboratory of Bioprospection in Antimicrobial Molecules (LABIMAN), Federal University of Ceara, Fortaleza, CE, Brazil; Drug Research and Development Center, Federal University of Ceara, Fortaleza, CE, Brazil.
de Moraes MO; Department of Physiology and Pharmacology, Federal University of Ceara, Fortaleza, CE, Brazil; Drug Research and Development Center, Federal University of Ceara, Fortaleza, CE, Brazil.
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Źródło :
Toxicology in vitro : an international journal published in association with BIBRA [Toxicol In Vitro] 2020 Feb; Vol. 62, pp. 104718. Date of Electronic Publication: 2019 Nov 09.
Typ publikacji :
Journal Article
MeSH Terms :
Anesthetics, Dissociative/*toxicity
Ketamine/*toxicity
Leukocytes/*drug effects
Mutagens/*toxicity
Salmonella typhimurium/*drug effects
Salmonella typhimurium/*genetics
Apoptosis/drug effects ; Cell Survival/drug effects ; Chromosome Aberrations/chemically induced ; Comet Assay ; DNA Breaks ; DNA Damage ; Hemolysis/drug effects ; Humans ; Lipid Peroxidation/drug effects ; Mutagenicity Tests ; Oxidative Stress
Czasopismo naukowe
Tytuł :
Impact of Bariatric Surgery on the Pharmacokinetics Parameters of Amoxicillin.
Autorzy :
Rocha MBS; Clinical Pharmacology Unit, Drug Research and Development Center, Federal University of Ceara (UFC), Rua Cel. Nunes de Melo 1000 - Rodolfo Teófilo, Fortaleza, Ceará, 60430-275, Brazil. .
De Nucci G; Faculty of Medical Sciences, Department of Pharmacology, State University of Campinas, Campinas, São Paulo, Brazil.
Lemos FN; Unit of Bariatric Surgery, Hospital General Dr. César Cals, Avenida Imperador, 545, centro, Fortaleza, 60015-152, CE, Brazil.
de Albuquerque Lima Babadopulos RF; Unit of Bariatric Surgery, Hospital General Dr. César Cals, Avenida Imperador, 545, centro, Fortaleza, 60015-152, CE, Brazil.
Rohleder AVP; Clinical Pharmacology Unit, Drug Research and Development Center, Federal University of Ceara (UFC), Rua Cel. Nunes de Melo 1000 - Rodolfo Teófilo, Fortaleza, Ceará, 60430-275, Brazil.
Fechine FV; Clinical Pharmacology Unit, Drug Research and Development Center, Federal University of Ceara (UFC), Rua Cel. Nunes de Melo 1000 - Rodolfo Teófilo, Fortaleza, Ceará, 60430-275, Brazil.
Antunes NJ; Faculty of Medical Sciences, Department of Pharmacology, State University of Campinas, Campinas, São Paulo, Brazil.
Mendes GD; Department of Pharmacology, Metropolitan University of Santos, Santos, Brazil.; Department of Pharmacology, Faculty Medicine, São Leopoldo Mandic, Campinas, Brazil.
do Nascimento DF; Clinical Pharmacology Unit, Drug Research and Development Center, Federal University of Ceara (UFC), Rua Cel. Nunes de Melo 1000 - Rodolfo Teófilo, Fortaleza, Ceará, 60430-275, Brazil.
de Moraes MO; Clinical Pharmacology Unit, Drug Research and Development Center, Federal University of Ceara (UFC), Rua Cel. Nunes de Melo 1000 - Rodolfo Teófilo, Fortaleza, Ceará, 60430-275, Brazil.
de Moraes MEA; Clinical Pharmacology Unit, Drug Research and Development Center, Federal University of Ceara (UFC), Rua Cel. Nunes de Melo 1000 - Rodolfo Teófilo, Fortaleza, Ceará, 60430-275, Brazil.
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Źródło :
Obesity surgery [Obes Surg] 2019 Mar; Vol. 29 (3), pp. 917-927.
Typ publikacji :
Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms :
Gastric Bypass*
Amoxicillin/*pharmacokinetics
Anti-Bacterial Agents/*pharmacokinetics
Obesity, Morbid/*metabolism
Obesity, Morbid/*surgery
Weight Loss/*physiology
Administration, Oral ; Adult ; Amoxicillin/administration & dosage ; Amoxicillin/blood ; Anti-Bacterial Agents/administration & dosage ; Anti-Bacterial Agents/blood ; Body Mass Index ; Chromatography, Liquid ; Female ; Humans ; Male ; Middle Aged ; Obesity, Morbid/blood ; Tandem Mass Spectrometry
Czasopismo naukowe
Tytuł :
Study of tensiometric properties, microbiological and collagen content in nile tilapia skin submitted to different sterilization methods.
Autorzy :
Alves APNN; Nursing, Dentistry and Pharmacy School of the Federal University of Ceara, 07, 17th Street, Maracanaú, Fortaleza, Ceará, 61925-430, Brazil.; Pharmaceutical Biochemistry of the Nuclear and Energy Research Institute of University of São Paulo (IPEN), São Paulo, Brazil.
Lima Júnior EM; Institute of Burning Support, Fortaleza, Ceará, Brazil.
Piccolo NS; First Aid Station for Burning of Goiânia, Goiânia, Goiás, Brazil.
de Miranda MJB; Hospital São Marcos/Rede Dor, Recife, Pernambuco, Brazil.
Lima Verde MEQ; Nursing, Dentistry and Pharmacy School of the Federal University of Ceara, 07, 17th Street, Maracanaú, Fortaleza, Ceará, 61925-430, Brazil.
Ferreira Júnior AEC; Nursing, Dentistry and Pharmacy School of the Federal University of Ceara, 07, 17th Street, Maracanaú, Fortaleza, Ceará, 61925-430, Brazil. .
de Barros Silva PG; Nursing, Dentistry and Pharmacy School of the Federal University of Ceara, 07, 17th Street, Maracanaú, Fortaleza, Ceará, 61925-430, Brazil.
Feitosa VP; Nursing, Dentistry and Pharmacy School of the Federal University of Ceara, 07, 17th Street, Maracanaú, Fortaleza, Ceará, 61925-430, Brazil.
de Bandeira TJPG; Microbiologist of Postgraduate Program in Medical Microbiology - Federal University of Ceara, Fortaleza, Ceará, Brazil.
Mathor MB; Pharmaceutical Biochemistry of the Nuclear and Energy Research Institute of University of São Paulo (IPEN), São Paulo, Brazil.
de Moraes MO; Drug Research and Development Center- NPDM/Fortaleza, Ceará, Brazil.
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Źródło :
Cell and tissue banking [Cell Tissue Bank] 2018 Sep; Vol. 19 (3), pp. 373-382. Date of Electronic Publication: 2018 Jan 29.
Typ publikacji :
Journal Article
MeSH Terms :
Cichlids/*microbiology
Collagen/*analysis
Skin/*microbiology
Skin/*ultrastructure
Sterilization/*methods
Animals ; Burns/therapy ; Gamma Rays ; Skin/drug effects ; Skin/radiation effects ; Tissue Engineering
Czasopismo naukowe
Tytuł :
Action mechanism of naphthofuranquinones against fluconazole-resistant Candida tropicalis strains evidenced by proteomic analysis: The role of increased endogenous ROS.
Autorzy :
de Andrade Neto JB; Department of Clinical and Toxicological Analysis, School of Pharmacy, Laboratory of Bioprospection and Experiments in Antimicrobial Molecules (LABIMAN), Federal University of Ceará, Fortaleza, CE, Brazil; Department of Pathology and Legal Medicine, School of Medicine, Federal University of Ceará, Fortaleza, CE, Brazil.
da Silva CR; Department of Clinical and Toxicological Analysis, School of Pharmacy, Laboratory of Bioprospection and Experiments in Antimicrobial Molecules (LABIMAN), Federal University of Ceará, Fortaleza, CE, Brazil; Christus University Center (UNICHRISTUS), Fortaleza, CE, Brazil.
Campos RS; Department of Clinical and Toxicological Analysis, School of Pharmacy, Laboratory of Bioprospection and Experiments in Antimicrobial Molecules (LABIMAN), Federal University of Ceará, Fortaleza, CE, Brazil; Christus University Center (UNICHRISTUS), Fortaleza, CE, Brazil.
do Nascimento FBSA; Department of Clinical and Toxicological Analysis, School of Pharmacy, Laboratory of Bioprospection and Experiments in Antimicrobial Molecules (LABIMAN), Federal University of Ceará, Fortaleza, CE, Brazil; Department of Pathology and Legal Medicine, School of Medicine, Federal University of Ceará, Fortaleza, CE, Brazil.
Sampaio LS; Department of Clinical and Toxicological Analysis, School of Pharmacy, Laboratory of Bioprospection and Experiments in Antimicrobial Molecules (LABIMAN), Federal University of Ceará, Fortaleza, CE, Brazil; Department of Pathology and Legal Medicine, School of Medicine, Federal University of Ceará, Fortaleza, CE, Brazil.
da Silva AR; Department of Clinical and Toxicological Analysis, School of Pharmacy, Laboratory of Bioprospection and Experiments in Antimicrobial Molecules (LABIMAN), Federal University of Ceará, Fortaleza, CE, Brazil.
Josino MAA; Department of Clinical and Toxicological Analysis, School of Pharmacy, Laboratory of Bioprospection and Experiments in Antimicrobial Molecules (LABIMAN), Federal University of Ceará, Fortaleza, CE, Brazil; Department of Pathology and Legal Medicine, School of Medicine, Federal University of Ceará, Fortaleza, CE, Brazil.
de Moraes MO; Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, CE, Brazil.
Lobo MDP; School of Pharmacy, University of Fortaleza, Fortaleza, CE, Brazil.
Moreno FBMB; School of Pharmacy, University of Fortaleza, Fortaleza, CE, Brazil.
Moreira ACOM; School of Pharmacy, University of Fortaleza, Fortaleza, CE, Brazil.
de Azevedo Moreira R; School of Pharmacy, University of Fortaleza, Fortaleza, CE, Brazil.
Grangeiro TB; Department of Biology, Science Center, Molecular Genetics Laboratory, Federal University of Ceará, CE, Brazil.
da Silva Júnior EN; Institute of Exact Sciences, Department of Chemistry, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
Magalhães HIF; Department of Pharmaceutical Sciences, Federal University of Paraiba, University City, João Pessoa, PB, Brazil.
Rocha DD; Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, CE, Brazil.
Cavalcanti BC; Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, CE, Brazil.
Júnior HVN; Department of Clinical and Toxicological Analysis, School of Pharmacy, Laboratory of Bioprospection and Experiments in Antimicrobial Molecules (LABIMAN), Federal University of Ceará, Fortaleza, CE, Brazil; Department of Pathology and Legal Medicine, School of Medicine, Federal University of Ceará, Fortaleza, CE, Brazil. Electronic address: .
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Źródło :
Microbial pathogenesis [Microb Pathog] 2018 Apr; Vol. 117, pp. 32-42. Date of Electronic Publication: 2017 Dec 08.
Typ publikacji :
Journal Article
MeSH Terms :
Proteomics*
Antifungal Agents/*pharmacology
Candida tropicalis/*drug effects
Candida tropicalis/*metabolism
Drug Resistance, Fungal/*drug effects
Drug Resistance, Fungal/*physiology
Naphthoquinones/*pharmacology
Reactive Oxygen Species/*metabolism
Antifungal Agents/chemical synthesis ; Antifungal Agents/chemistry ; Candida tropicalis/genetics ; Candidemia/microbiology ; Cell Cycle/drug effects ; DNA Damage/drug effects ; DNA, Fungal/genetics ; Energy Metabolism/drug effects ; Fluconazole/pharmacology ; Glycolysis/drug effects ; Membrane Potential, Mitochondrial/drug effects ; Microbial Sensitivity Tests ; Mitochondria/drug effects ; Naphthoquinones/chemical synthesis ; Naphthoquinones/chemistry ; Stress, Psychological
Czasopismo naukowe
Tytuł :
Tryptophan catabolites along the indoleamine 2,3-dioxygenase pathway as a biological link between depression and cancer.
Autorzy :
Barreto FS; Laboratory of Experimental Oncology.
Chaves Filho AJM; Neuropsychopharmacology Laboratory.
de Araújo MCCR; Clinical Pharmacology Unit, Drug Research and Development Center, Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil.
de Moraes MO; Laboratory of Experimental Oncology.
de Moraes MEA; Clinical Pharmacology Unit, Drug Research and Development Center, Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil.
Maes M; Impact Strategic Research Center, Department of Psychiatry, Deakin University, Geelong, Victoria, Australia.; Department of Psychiatry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
de Lucena DF; Neuropsychopharmacology Laboratory.
Macedo DS; Neuropsychopharmacology Laboratory.
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Źródło :
Behavioural pharmacology [Behav Pharmacol] 2018 Apr; Vol. 29 (2 and 3-Spec Issue), pp. 165-180.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Indoleamine-Pyrrole 2,3,-Dioxygenase/*physiology
Tryptophan/*metabolism
Tryptophan/*physiology
Animals ; Depression/immunology ; Depression/metabolism ; Depression/physiopathology ; Depressive Disorder/physiopathology ; Humans ; Immunity/physiology ; Indoleamine-Pyrrole 2,3,-Dioxygenase/drug effects ; Indoles ; Inflammation ; Neoplasms/immunology ; Neoplasms/physiopathology ; Oxidative Stress ; Serotonin ; Signal Transduction/physiology
Czasopismo naukowe
Tytuł :
Annonalide and derivatives: Semisynthesis, cytotoxic activities and studies on interaction of annonalide with DNA.
Autorzy :
Marques RA; Department of Organic and Inorganic Chemistry, Federal University of Ceará, Fortaleza, Ceará, Brazil; Northern Educational Union - UNINORTE, Rio Branco, Acre, Brazil.
Gomes AOCV; Department of Organic and Inorganic Chemistry, Federal University of Ceará, Fortaleza, Ceará, Brazil.
de Brito MV; Department of Organic and Inorganic Chemistry, Federal University of Ceará, Fortaleza, Ceará, Brazil.
Dos Santos ALP; Department of Organic and Inorganic Chemistry, Federal University of Ceará, Fortaleza, Ceará, Brazil.
da Silva GS; Department of Organic and Inorganic Chemistry, Federal University of Ceará, Fortaleza, Ceará, Brazil.
de Lima LB; Department of Organic and Inorganic Chemistry, Federal University of Ceará, Fortaleza, Ceará, Brazil; Catholic Center of Quixadá - Unicatólica, Quixadá, Ceará, Brazil.
Nunes FM; Department of Organic and Inorganic Chemistry, Federal University of Ceará, Fortaleza, Ceará, Brazil.
de Mattos MC; Department of Organic and Inorganic Chemistry, Federal University of Ceará, Fortaleza, Ceará, Brazil.
de Oliveira FCE; Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, Ceará, Brazil.
do Ó Pessoa C; Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, Ceará, Brazil.
de Moraes MO; Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, Ceará, Brazil.
de Fátima Â; Department of Chemistry, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Franco LL; Department of Chemistry, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Silva MM; Institute of Chemistry and Biotechnology, Federal University of Alagoas, Maceió, Alagoas, Brazil.
Dantas MDA; Institute of Chemistry and Biotechnology, Federal University of Alagoas, Maceió, Alagoas, Brazil.
Santos JCC; Institute of Chemistry and Biotechnology, Federal University of Alagoas, Maceió, Alagoas, Brazil.
Figueiredo IM; Institute of Chemistry and Biotechnology, Federal University of Alagoas, Maceió, Alagoas, Brazil.
da Silva-Júnior EF; Institute of Chemistry and Biotechnology, Federal University of Alagoas, Maceió, Alagoas, Brazil.
de Aquino TM; Institute of Chemistry and Biotechnology, Federal University of Alagoas, Maceió, Alagoas, Brazil.
de Araújo-Júnior JX; Institute of Chemistry and Biotechnology, Federal University of Alagoas, Maceió, Alagoas, Brazil; Nursing and Pharmacy School, Federal University of Alagoas, Maceió, Alagoas, Brazil.
de Oliveira MCF; Department of Organic and Inorganic Chemistry, Federal University of Ceará, Fortaleza, Ceará, Brazil. Electronic address: .
Leslie Gunatilaka AA; Natural Products Center, University of Arizona, Tucson, AZ, United States.
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Źródło :
Journal of photochemistry and photobiology. B, Biology [J Photochem Photobiol B] 2018 Feb; Vol. 179, pp. 156-166. Date of Electronic Publication: 2018 Feb 03.
Typ publikacji :
Journal Article
MeSH Terms :
Cyclooctanes/*chemistry
DNA/*chemistry
Ketones/*chemistry
Animals ; Binding Sites ; Cattle ; Cell Line, Tumor ; Cell Survival ; Cyclooctanes/chemical synthesis ; Cyclooctanes/toxicity ; DNA/metabolism ; Drug Screening Assays, Antitumor ; Humans ; Ketones/chemical synthesis ; Ketones/toxicity ; Molecular Docking Simulation ; Nucleic Acid Conformation ; Spectrophotometry ; Static Electricity ; Thermodynamics ; Transition Temperature
Czasopismo naukowe
Tytuł :
Impact of testicular sperm extraction and testicular sperm aspiration on gonadal function in an experimental rat model.
Autorzy :
Barroso LVS; Divisão de Urologia, Universidade Federal do Ceará, CE, Brasil.
Reges R; Divisão de Urologia, Universidade Federal do Ceará, CE, Brasil.
Cerqueira JBG; Divisão de Urologia, Universidade Federal do Ceará, CE, Brasil.
Miranda EP; Divisão de Urologia, Universidade Federal do Ceará, CE, Brasil.
de Alcantara RJA; Divisão de Urologia, Universidade Federal do Ceará, CE, Brasil.
Jamacaru FVF; Departamento de Farmacologia, Universidade Federal do Ceará, CE, Brasil.
de Moraes MO; Departamento de Farmacologia, Universidade Federal do Ceará, CE, Brasil.
Medeiros MADS; Departamento de Farmacologia, Universidade Federal do Ceará, CE, Brasil.
Gonzaga-Silva LF; Divisão de Urologia, Universidade Federal do Ceará, CE, Brasil.
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Źródło :
International braz j urol : official journal of the Brazilian Society of Urology [Int Braz J Urol] 2018 Jan-Feb; Vol. 44 (1), pp. 172-179.
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
Sperm Retrieval*/adverse effects
Sperm Motility/*physiology
Spermatogenesis/*physiology
Spermatozoa/*physiology
Testis/*physiology
Animals ; Male ; Models, Animal ; Orchiopexy/methods ; Pilot Projects ; Random Allocation ; Rats ; Rats, Wistar ; Testis/surgery ; Testosterone/biosynthesis
Czasopismo naukowe
Tytuł :
In vitro anti-Candida activity of selective serotonin reuptake inhibitors against fluconazole-resistant strains and their activity against biofilm-forming isolates.
Autorzy :
Costa Silva RA; Department of Clinical and Toxicological Analysis, School of Pharmacy, Laboratory of Bioprospection in Antimicrobial Molecules (LABIMAN), Federal University of Ceará, Fortaleza, CE, Brazil; Department of Pathology and Legal Medicine, School of Medicine, Federal University of Ceará, Fortaleza, CE, Brazil.
da Silva CR; Department of Clinical and Toxicological Analysis, School of Pharmacy, Laboratory of Bioprospection in Antimicrobial Molecules (LABIMAN), Federal University of Ceará, Fortaleza, CE, Brazil; Christus University Center (UNICHRISTUS), Fortaleza, CE, Brazil.
de Andrade Neto JB; Department of Clinical and Toxicological Analysis, School of Pharmacy, Laboratory of Bioprospection in Antimicrobial Molecules (LABIMAN), Federal University of Ceará, Fortaleza, CE, Brazil; Department of Pathology and Legal Medicine, School of Medicine, Federal University of Ceará, Fortaleza, CE, Brazil.
da Silva AR; Department of Clinical and Toxicological Analysis, School of Pharmacy, Laboratory of Bioprospection in Antimicrobial Molecules (LABIMAN), Federal University of Ceará, Fortaleza, CE, Brazil.
Campos RS; Department of Clinical and Toxicological Analysis, School of Pharmacy, Laboratory of Bioprospection in Antimicrobial Molecules (LABIMAN), Federal University of Ceará, Fortaleza, CE, Brazil; Christus University Center (UNICHRISTUS), Fortaleza, CE, Brazil.
Sampaio LS; Department of Clinical and Toxicological Analysis, School of Pharmacy, Laboratory of Bioprospection in Antimicrobial Molecules (LABIMAN), Federal University of Ceará, Fortaleza, CE, Brazil; Department of Pathology and Legal Medicine, School of Medicine, Federal University of Ceará, Fortaleza, CE, Brazil.
do Nascimento FBSA; Department of Clinical and Toxicological Analysis, School of Pharmacy, Laboratory of Bioprospection in Antimicrobial Molecules (LABIMAN), Federal University of Ceará, Fortaleza, CE, Brazil; Department of Pathology and Legal Medicine, School of Medicine, Federal University of Ceará, Fortaleza, CE, Brazil.
da Silva Gaspar B; Department of Clinical and Toxicological Analysis, School of Pharmacy, Laboratory of Bioprospection in Antimicrobial Molecules (LABIMAN), Federal University of Ceará, Fortaleza, CE, Brazil.
da Cruz Fonseca SG; Department of Clinical and Toxicological Analysis, School of Pharmacy, Laboratory of Bioprospection in Antimicrobial Molecules (LABIMAN), Federal University of Ceará, Fortaleza, CE, Brazil.
Josino MAA; Department of Clinical and Toxicological Analysis, School of Pharmacy, Laboratory of Bioprospection in Antimicrobial Molecules (LABIMAN), Federal University of Ceará, Fortaleza, CE, Brazil; Department of Pathology and Legal Medicine, School of Medicine, Federal University of Ceará, Fortaleza, CE, Brazil.
Grangeiro TB; Department of Biology, Science Center, Molecular Genetics Laboratory, Federal University of Ceará, CE, Brazil.
Gaspar DM; Department of Physiology and Pharmacology, Neuropharmacology Laboratory, Federal University of Ceará, Fortaleza, CE, Brazil.
de Lucena DF; Department of Physiology and Pharmacology, Neuropharmacology Laboratory, Federal University of Ceará, Fortaleza, CE, Brazil.
de Moraes MO; Department of Physiology and Pharmacology, Neuropharmacology Laboratory, Federal University of Ceará, Fortaleza, CE, Brazil.
Cavalcanti BC; Department of Physiology and Pharmacology, Neuropharmacology Laboratory, Federal University of Ceará, Fortaleza, CE, Brazil.
Nobre Júnior HV; Department of Clinical and Toxicological Analysis, School of Pharmacy, Laboratory of Bioprospection in Antimicrobial Molecules (LABIMAN), Federal University of Ceará, Fortaleza, CE, Brazil; Department of Pathology and Legal Medicine, School of Medicine, Federal University of Ceará, Fortaleza, CE, Brazil. Electronic address: .
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Źródło :
Microbial pathogenesis [Microb Pathog] 2017 Jun; Vol. 107, pp. 341-348. Date of Electronic Publication: 2017 Apr 12.
Typ publikacji :
Journal Article
MeSH Terms :
Antifungal Agents/*pharmacology
Biofilms/*drug effects
Candida/*drug effects
Drug Resistance, Fungal/*drug effects
Fluconazole/*pharmacology
Serotonin Uptake Inhibitors/*pharmacology
Animals ; Apoptosis/drug effects ; Biofilms/growth & development ; Candida/cytology ; Candida/genetics ; Candida/growth & development ; Cell Count ; Cell Death/drug effects ; Cell Line ; Cell Proliferation/drug effects ; DNA Damage/drug effects ; DNA, Fungal/drug effects ; Fibroblasts/microbiology ; Flow Cytometry ; In Vitro Techniques ; Membrane Potentials ; Mice ; Microbial Sensitivity Tests ; Microbial Viability/drug effects ; Mitochondrial Membranes/drug effects ; Paroxetine/pharmacology ; Plasma/drug effects ; Serotonin Uptake Inhibitors/administration & dosage ; Sertraline/pharmacology
Czasopismo naukowe
Tytuł :
Occupational and life-style factors-acquired mutagenicity in agric-workers of northeastern Brazil.
Autorzy :
Chaves TVS; Department of Health, Board of Health Surveillance of Piauí, Teresina, Brazil.
Islam MT; Postgraduate Program in Biotechnology, Federal University of Piauí, Teresina, Piauí, 64.049-550, Brazil. .; Department of Pharmacy, Southern University Bangladesh, Mehedigbag, Chittagong, 4000, Bangladesh. .
de Moraes MO; Department of Health, Board of Health Surveillance of Piauí, Teresina, Brazil.
de Alencar MVOB; Postgraduate Program in Biotechnology, Federal University of Piauí, Teresina, Piauí, 64.049-550, Brazil.
Gomes DCV; Postgraduate Program in Biotechnology, Federal University of Piauí, Teresina, Piauí, 64.049-550, Brazil.
de Carvalho RM; Postgraduate Program in Biotechnology, Federal University of Piauí, Teresina, Piauí, 64.049-550, Brazil.
Maluf SW; Medical Genetics Service, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.
de Moura do Amaral FP; Department of Health, Board of Health Surveillance of Piauí, Teresina, Brazil.
Paz MFCJ; Postgraduate Program in Cellular and Molecular Biology Applied to Health, Lutheran University of Brazil, Canoas, Brazil.
Cerqueira GS; Postgraduate Program in Biotechnology, Federal University of Piauí, Teresina, Piauí, 64.049-550, Brazil.
Rolim HML; Federal University of Piauí, Teresina, Piauí, 64.049-550, Brazil.
de Castro E Sousa JM; Federal University of Piauí, Teresina, Piauí, 64.049-550, Brazil.; Department of Biological Sciences, Federal University of Piauí, Picos, PI, 64.600-000, Brazil.
de Carvalho Melo-Cavalcante AA; Postgraduate Program in Biotechnology, Federal University of Piauí, Teresina, Piauí, 64.049-550, Brazil.; Federal University of Piauí, Teresina, Piauí, 64.049-550, Brazil.
de Moraes MEA; Department of Clinical Pharmacology, Federal University of Ceará, Fortaleza, Brazil.
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Źródło :
Environmental science and pollution research international [Environ Sci Pollut Res Int] 2017 Jun; Vol. 24 (18), pp. 15454-15461. Date of Electronic Publication: 2017 May 16.
Typ publikacji :
Journal Article
MeSH Terms :
Chromosome Aberrations*
Occupational Exposure*
Mutagens/*toxicity
Pesticides/*toxicity
Adolescent ; Adult ; Aged ; Alcohol Drinking ; Brazil ; DNA Damage ; Diet ; Farmers ; Humans ; Life Style ; Lymphocytes ; Male ; Micronucleus Tests ; Middle Aged ; Smoking ; Young Adult
Czasopismo naukowe
Tytuł :
Behavioral effects induced by antitumor cleronade diterpenes from Casearia sylvestris and in silico interactions with neuron receptors.
Autorzy :
de Araújo ÉJF; Postgraduate Program in Pharmaceutical Sciences, Federal University of Piauí, Teresina, Brazil; Department of Pharmacy, Federal University of Piauí, Teresina, Brazil.
de Almeida AAC; Postgraduate Program in Biotechnology (RENORBIO), Federal University of Piauí, Teresina, Brazil.
Silva OA; Postgraduate Program in Biotechnology (RENORBIO), Federal University of Piauí, Teresina, Brazil.
da Costa IHF; Department of Pharmacy, Federal University of Piauí, Teresina, Brazil.
Rezende-Júnior LM; Department of Pharmacy, Federal University of Piauí, Teresina, Brazil.
Lima FDCA; Postgraduate Program in Biotechnology (RENORBIO), Federal University of Piauí, Teresina, Brazil; Quantum Computational Chemistry Laboratory, Department of Chemistry, State University of Piauí, Teresina, Piauí, Brazil.
Cavalheiro AJ; Department of Organic Chemisty, Chemistry Institute, State University of São Paulo Júlio de Mesquita Filho, Araraquara, Brazil.
Pessoa C; Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceará, Fortaleza, Brazil.
de Moraes MO; Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceará, Fortaleza, Brazil.
Ferreira PMP; Postgraduate Program in Pharmaceutical Sciences, Federal University of Piauí, Teresina, Brazil; Postgraduate Program in Biotechnology (RENORBIO), Federal University of Piauí, Teresina, Brazil; Department of Biophysics and Physiology, Laboratory of Experimental Cancerology, Federal University of Piauí, Teresina, Brazil. Electronic address: .
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Źródło :
Journal of ethnopharmacology [J Ethnopharmacol] 2017 Feb 23; Vol. 198, pp. 460-467. Date of Electronic Publication: 2017 Jan 07.
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
Behavior, Animal/*drug effects
Casearia/*chemistry
Diterpenes/*pharmacology
Plant Extracts/*pharmacology
Animals ; Anti-Anxiety Agents/administration & dosage ; Anti-Anxiety Agents/isolation & purification ; Anti-Anxiety Agents/pharmacology ; Antineoplastic Agents, Phytogenic/isolation & purification ; Antineoplastic Agents, Phytogenic/pharmacology ; Computer Simulation ; Diazepam/pharmacology ; Diterpenes/administration & dosage ; Diterpenes/isolation & purification ; Dopamine/metabolism ; Dose-Response Relationship, Drug ; Male ; Maze Learning/drug effects ; Mice ; Neurons/drug effects ; Plant Extracts/administration & dosage ; Plant Extracts/toxicity
Czasopismo naukowe

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