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Tytuł:
Haptoglobin phenotype is not a predictor of recurrence free survival in high-risk primary breast cancer patients.
Autorzy:
Gast MC
van Tinteren H
Bontenbal M
van Hoesel RQ
Nooij MA
Rodenhuis S
Span PN
Tjan-Heijnen VC
de Vries EG
Harris N
Twisk JW
Schellens JH
Beijnen JH
Gast, Marie-Christine W
van Tinteren, Harm
Bontenbal, Marijke
van Hoesel, René Q G C M
Nooij, Marianne A
Rodenhuis, Sjoerd
Span, Paul N
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Źródło:
BMC Cancer; 2008, Vol. 8, p389-389, 1p
Czasopismo naukowe
Tytuł:
ATR inhibition preferentially targets homologous recombination-deficient tumor cells.
Autorzy:
Krajewska M; Department of Medical Onclology, University Medical Center Groningen, University of Groningen, The Netherlands.
Fehrmann RS; Department of Medical Onclology, University Medical Center Groningen, University of Groningen, The Netherlands.
Schoonen PM; Department of Medical Onclology, University Medical Center Groningen, University of Groningen, The Netherlands.
Labib S; Department of Medical Onclology, University Medical Center Groningen, University of Groningen, The Netherlands.
de Vries EG; Department of Medical Onclology, University Medical Center Groningen, University of Groningen, The Netherlands.
Franke L; Department of Medical Genetics, University Medical Center Groningen, University of Groningen, The Netherlands.
van Vugt MA; Department of Medical Onclology, University Medical Center Groningen, University of Groningen, The Netherlands.
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Źródło:
Oncogene [Oncogene] 2015 Jun; Vol. 34 (26), pp. 3474-81. Date of Electronic Publication: 2014 Sep 01.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antineoplastic Agents/*therapeutic use
Homologous Recombination/*genetics
Neoplasms/*drug therapy
Neoplasms/*genetics
Pyrazines/*therapeutic use
Sulfones/*therapeutic use
Ataxia Telangiectasia Mutated Proteins/antagonists & inhibitors ; Cell Survival/drug effects ; Cell Survival/genetics ; Checkpoint Kinase 1 ; Drug Resistance, Neoplasm/drug effects ; Drug Resistance, Neoplasm/genetics ; HeLa Cells ; Humans ; MCF-7 Cells ; Molecular Targeted Therapy ; Protein Kinases/genetics ; Signal Transduction/drug effects ; Signal Transduction/genetics ; Thiophenes/therapeutic use ; Urea/analogs & derivatives ; Urea/therapeutic use
Czasopismo naukowe
Tytuł:
The value of PET/CT with FES or FDG tracers in metastatic breast cancer: a computer simulation study in ER-positive patients.
Autorzy:
Koleva-Kolarova RG; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9713GZ Groningen, The Netherlands.
Greuter MJ; Department of Radiology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9713GZ Groningen, The Netherlands.
van Kruchten M; Department of Medical Oncology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9713GZ Groningen, The Netherlands.
Vermeulen KM; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9713GZ Groningen, The Netherlands.
Feenstra T; 1] Department of Epidemiology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9713GZ Groningen, The Netherlands [2] RIVM, Antonie van Leeuwenhoeklaan, 3721MA Bilthoven, The Netherlands.
Buskens E; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9713GZ Groningen, The Netherlands.
Glaudemans AW; Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9713GZ Groningen, The Netherlands.
de Vries EF; Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9713GZ Groningen, The Netherlands.
de Vries EG; Department of Medical Oncology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9713GZ Groningen, The Netherlands.
Hospers GA; Department of Medical Oncology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9713GZ Groningen, The Netherlands.
de Bock GH; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9713GZ Groningen, The Netherlands.
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Źródło:
British journal of cancer [Br J Cancer] 2015 May 12; Vol. 112 (10), pp. 1617-25. Date of Electronic Publication: 2015 Apr 16.
Typ publikacji:
Journal Article
MeSH Terms:
Fluorodeoxyglucose F18*
Breast Neoplasms/*diagnostic imaging
Estradiol/*analogs & derivatives
Receptors, Estrogen/*biosynthesis
Biopsy/economics ; Biopsy/methods ; Breast Neoplasms/genetics ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Computer Simulation ; Diagnostic Imaging/methods ; Female ; Humans ; Neoplasm Metastasis ; Neoplasm Staging/methods ; Positron-Emission Tomography/methods ; Radiopharmaceuticals ; Receptors, Estrogen/genetics ; Reproducibility of Results ; Sensitivity and Specificity ; Tomography, X-Ray Computed/methods
Czasopismo naukowe
Tytuł:
BMI and lifetime changes in BMI and cancer mortality risk.
Autorzy:
Taghizadeh N; University of Groningen, University Medical Centre Groningen, Department of Epidemiology, Groningen, the Netherlands.
Boezen HM; University of Groningen, University Medical Centre Groningen, Department of Epidemiology, Groningen, the Netherlands.; University of Groningen, University Medical Centre Groningen, GRIAC research institute, Groningen, the Netherlands.
Schouten JP; University of Groningen, University Medical Centre Groningen, Department of Epidemiology, Groningen, the Netherlands.; University of Groningen, University Medical Centre Groningen, GRIAC research institute, Groningen, the Netherlands.
Schröder CP; University of Groningen, University Medical Centre Groningen, Department of Medical Oncology, Groningen, the Netherlands.
Elisabeth de Vries EG; University of Groningen, University Medical Centre Groningen, Department of Medical Oncology, Groningen, the Netherlands.
Vonk JM; University of Groningen, University Medical Centre Groningen, Department of Epidemiology, Groningen, the Netherlands.; University of Groningen, University Medical Centre Groningen, GRIAC research institute, Groningen, the Netherlands.
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Źródło:
PloS one [PLoS One] 2015 Apr 16; Vol. 10 (4), pp. e0125261. Date of Electronic Publication: 2015 Apr 16 (Print Publication: 2015).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Body Mass Index*
Mortality/*trends
Neoplasms/*mortality
Obesity/*physiopathology
Adult ; Aged ; Female ; Humans ; Male ; Middle Aged ; Neoplasms/epidemiology ; Prognosis ; Risk Factors ; Survival Rate ; Time Factors ; Young Adult
Czasopismo naukowe
Tytuł:
Gene expression analysis identifies global gene dosage sensitivity in cancer.
Autorzy:
Fehrmann RS; 1] Department of Medical Oncology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. [2] Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Karjalainen JM; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Krajewska M; Department of Medical Oncology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Westra HJ; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Maloney D; National Center for Advancing Translational Sciences, US National Institutes of Health, Rockville, Maryland, USA.
Simeonov A; National Center for Advancing Translational Sciences, US National Institutes of Health, Rockville, Maryland, USA.
Pers TH; 1] Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA. [2] Division of Endocrinology, Children's Hospital Boston, Boston, Massachusetts, USA. [3] Center for Basic and Translational Obesity Research, Children's Hospital Boston, Boston, Massachusetts, USA. [4] Department of Systems Biology, Center for Biological Sequence Analysis, Technical University of Denmark, Lyngby, Denmark.
Hirschhorn JN; 1] Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA. [2] Division of Endocrinology, Children's Hospital Boston, Boston, Massachusetts, USA. [3] Center for Basic and Translational Obesity Research, Children's Hospital Boston, Boston, Massachusetts, USA. [4] Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA.
Jansen RC; Groningen Bioinformatics Centre, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Haren, the Netherlands.
Schultes EA; 1] Department of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands. [2] BioSemantics Group, Leiden Institute of Advanced Computer Science, Leiden University, Leiden, the Netherlands.
van Haagen HH; Department of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands.
de Vries EG; Department of Medical Oncology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
te Meerman GJ; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Wijmenga C; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
van Vugt MA; Department of Medical Oncology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Franke L; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
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Źródło:
Nature genetics [Nat Genet] 2015 Feb; Vol. 47 (2), pp. 115-25. Date of Electronic Publication: 2015 Jan 12.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
DNA Copy Number Variations*
Gene Dosage*
Genomics*
Transcriptome*
Gene Expression Regulation, Neoplastic/*genetics
Neoplasms/*genetics
Comparative Genomic Hybridization ; Gene Expression Profiling ; Gene Regulatory Networks ; Genetic Loci ; Humans ; RNA, Messenger/genetics ; RNA, Neoplasm/genetics
Czasopismo naukowe
Tytuł:
Growth differentiation factor 15 (GDF-15) plasma levels increase during bleomycin- and cisplatin-based treatment of testicular cancer patients and relate to endothelial damage.
Autorzy:
Altena R; Department of Medical Oncology, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands.
Fehrmann RS; Department of Medical Oncology, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands; Department of Genetics, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands.
Boer H; Department of Medical Oncology, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands.
de Vries EG; Department of Medical Oncology, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands.
Meijer C; Department of Medical Oncology, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands.
Gietema JA; Department of Medical Oncology, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands.
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Źródło:
PloS one [PLoS One] 2015 Jan 15; Vol. 10 (1), pp. e0115372. Date of Electronic Publication: 2015 Jan 15 (Print Publication: 2015).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antineoplastic Combined Chemotherapy Protocols/*therapeutic use
Bleomycin/*therapeutic use
Cisplatin/*therapeutic use
Endothelial Cells/*drug effects
Growth Differentiation Factor 15/*blood
Testicular Neoplasms/*blood
Activating Transcription Factor 3/blood ; Adolescent ; Adult ; Amphiregulin/blood ; Antineoplastic Combined Chemotherapy Protocols/pharmacology ; Biomarkers, Tumor/blood ; Bleomycin/pharmacology ; Cell Line ; Cisplatin/pharmacology ; Endothelial Cells/metabolism ; Endothelial Cells/pathology ; Endothelium, Vascular/drug effects ; Endothelium, Vascular/metabolism ; Endothelium, Vascular/pathology ; Humans ; Male ; Middle Aged ; Testicular Neoplasms/drug therapy ; Testicular Neoplasms/pathology ; Young Adult ; von Willebrand Factor/metabolism
Czasopismo naukowe
Tytuł:
Myocardial metastases on 6-[18F] fluoro-L-DOPA PET/CT: a retrospective analysis of 116 serotonin producing neuroendocrine tumour patients.
Autorzy:
Noordzij W; Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
van Beek AP; Department of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Tio RA; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
van der Horst-Schrivers AN; Department of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
de Vries EG; Department of Medical Oncology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
van Ginkel B; Faculty of Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Walenkamp AM; Department of Medical Oncology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Glaudemans AW; Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Slart RH; Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Dierckx RA; Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
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Źródło:
PloS one [PLoS One] 2014 Nov 14; Vol. 9 (11), pp. e112278. Date of Electronic Publication: 2014 Nov 14 (Print Publication: 2014).
Typ publikacji:
Journal Article
MeSH Terms:
Positron-Emission Tomography*
Tomography, X-Ray Computed*
Dihydroxyphenylalanine/*analogs & derivatives
Heart Neoplasms/*secondary
Myocardium/*pathology
Serotonin/*biosynthesis
Carcinoid Heart Disease/complications ; Carcinoid Heart Disease/diagnostic imaging ; Female ; Heart Neoplasms/diagnostic imaging ; Humans ; Male ; Middle Aged ; Multimodal Imaging ; Neuroendocrine Tumors/diagnostic imaging ; Neuroendocrine Tumors/pathology ; Retrospective Studies ; Ultrasonography
Czasopismo naukowe
Tytuł:
Nutlin-3 preferentially sensitises wild-type p53-expressing cancer cells to DR5-selective TRAIL over rhTRAIL.
Autorzy:
Meijer A; Department of Medical Oncology, Cancer Research Center Groningen, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.
Kruyt FA
van der Zee AG
Hollema H
Le P
ten Hoor KA
Groothuis GM
Quax WJ
de Vries EG
de Jong S
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Źródło:
British journal of cancer [Br J Cancer] 2013 Nov 12; Vol. 109 (10), pp. 2685-95. Date of Electronic Publication: 2013 Oct 17.
Typ publikacji:
Journal Article
MeSH Terms:
Apoptosis/*drug effects
Imidazoles/*pharmacology
Neoplasms/*pathology
Piperazines/*pharmacology
Receptors, TNF-Related Apoptosis-Inducing Ligand/*agonists
Recombinant Proteins/*pharmacology
TNF-Related Apoptosis-Inducing Ligand/*pharmacology
Amino Acid Substitution ; Apoptosis/genetics ; Drug Resistance, Neoplasm/drug effects ; Drug Resistance, Neoplasm/genetics ; Drug Synergism ; Genes, p53 ; Humans ; Neoplasms/genetics ; Receptors, TNF-Related Apoptosis-Inducing Ligand/metabolism ; Recombinant Proteins/genetics ; Substrate Specificity ; TNF-Related Apoptosis-Inducing Ligand/genetics ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł:
Forced activation of Cdk1 via wee1 inhibition impairs homologous recombination.
Autorzy:
Krajewska M; Department of Medical Oncology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Heijink AM
Bisselink YJ
Seinstra RI
Silljé HH
de Vries EG
van Vugt MA
Pokaż więcej
Źródło:
Oncogene [Oncogene] 2013 Jun 13; Vol. 32 (24), pp. 3001-8. Date of Electronic Publication: 2012 Jul 16.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
CDC2 Protein Kinase/*metabolism
Cell Cycle Proteins/*antagonists & inhibitors
Homologous Recombination/*drug effects
Nuclear Proteins/*antagonists & inhibitors
Protein Kinase Inhibitors/*pharmacology
Protein-Tyrosine Kinases/*antagonists & inhibitors
DNA Damage ; Enzyme Activation/drug effects ; Humans ; MCF-7 Cells ; Pyrazoles/pharmacology ; Pyrimidines/pharmacology ; Pyrimidinones ; Quinolines/pharmacology ; Thiazoles/pharmacology
Czasopismo naukowe
Tytuł:
Inhibition of formyl peptide receptor in high-grade astrocytoma by CHemotaxis Inhibitory Protein of S. aureus.
Autorzy:
Boer JC; Department of Medical Oncology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9700 RB Groningen, The Netherlands.
Domanska UM
Timmer-Bosscha H
Boer IG
de Haas CJ
Joseph JV
Kruyt FA
de Vries EG
den Dunnen WF
van Strijp JA
Walenkamp AM
Pokaż więcej
Źródło:
British journal of cancer [Br J Cancer] 2013 Feb 19; Vol. 108 (3), pp. 587-96. Date of Electronic Publication: 2013 Jan 15.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Astrocytoma/*pathology
Astrocytoma/*prevention & control
Bacterial Proteins/*pharmacology
Brain Neoplasms/*prevention & control
Chemotaxis/*drug effects
Peptide Fragments/*pharmacology
Receptors, Formyl Peptide/*antagonists & inhibitors
Animals ; Astrocytoma/metabolism ; Blotting, Western ; Brain Neoplasms/metabolism ; Brain Neoplasms/pathology ; Calcium/metabolism ; Cell Movement/drug effects ; Enzyme-Linked Immunosorbent Assay ; Humans ; Immunoenzyme Techniques ; Mice ; Mice, Inbred NOD ; Mice, SCID ; Neoplasm Grading ; Receptors, Formyl Peptide/metabolism ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł:
HIF-1α overexpression in ductal carcinoma in situ of the breast in BRCA1 and BRCA2 mutation carriers.
Autorzy:
van der Groep P; Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands. />van Diest PJ
Smolders YH
Ausems MG
van der Luijt RB
Menko FH
Bart J
de Vries EG
van der Wall E
Pokaż więcej
Źródło:
PloS one [PLoS One] 2013; Vol. 8 (2), pp. e56055. Date of Electronic Publication: 2013 Feb 08.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
BRCA1 Protein/*metabolism
BRCA2 Protein/*metabolism
Breast Neoplasms/*metabolism
Carcinoma, Intraductal, Noninfiltrating/*metabolism
Hypoxia-Inducible Factor 1, alpha Subunit/*metabolism
Adult ; Aged ; BRCA1 Protein/genetics ; BRCA2 Protein/genetics ; Breast Neoplasms/genetics ; Breast Neoplasms/pathology ; Carcinoma, Intraductal, Noninfiltrating/genetics ; Carcinoma, Intraductal, Noninfiltrating/pathology ; Female ; Gene Expression Regulation, Neoplastic ; Germ-Line Mutation ; Heterozygote ; Humans ; Hypoxia ; Hypoxia-Inducible Factor 1, alpha Subunit/genetics ; Middle Aged ; Neoplasm Grading ; Neoplasm Invasiveness
Czasopismo naukowe
Tytuł:
Phase I study of saracatinib (AZD0530) in combination with paclitaxel and/or carboplatin in patients with solid tumours.
Autorzy:
Kaye S; Drug Development Unit, Royal Marsden Hospital, Downs Road, Sutton, Surrey SM2 5PT, UK. />Aamdal S
Jones R
Freyer G
Pujade-Lauraine E
de Vries EG
Barriuso J
Sandhu S
Tan DS
Hartog V
Kuenen B
Ruijter R
Kristensen GB
Nyakas M
Barrett S
Burke W
Pietersma D
Stuart M
Emeribe U
Boven E
Pokaż więcej
Źródło:
British journal of cancer [Br J Cancer] 2012 May 22; Vol. 106 (11), pp. 1728-34. Date of Electronic Publication: 2012 Apr 24.
Typ publikacji:
Clinical Trial, Phase I; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
MeSH Terms:
Antineoplastic Combined Chemotherapy Protocols/*therapeutic use
Benzodioxoles/*administration & dosage
Neoplasms/*drug therapy
Quinazolines/*administration & dosage
Adult ; Aged ; Benzodioxoles/adverse effects ; Carboplatin/administration & dosage ; Carboplatin/adverse effects ; Dose-Response Relationship, Drug ; Female ; Humans ; Male ; Middle Aged ; Paclitaxel/administration & dosage ; Paclitaxel/adverse effects ; Quinazolines/adverse effects
Czasopismo naukowe

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