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Tytuł :
Special AT-rich sequence-binding protein 2 (Satb2) synergizes with Bmp9 and is essential for osteo/odontogenic differentiation of mouse incisor mesenchymal stem cells.
Autorzy :
Chen Q; Chongqing Key Laboratory for Oral Diseases and Biomedical Sciences, The Affiliated Hospital of Stomatology of Chongqing Medical University, Chongqing, China.; Department of Pediatric Dentistry, The Affiliated Stomatology Hospital, Chongqing Medical University, Chongqing, China.
Zheng L; Chongqing Key Laboratory for Oral Diseases and Biomedical Sciences, The Affiliated Hospital of Stomatology of Chongqing Medical University, Chongqing, China.; Department of Pediatric Dentistry, The Affiliated Stomatology Hospital, Chongqing Medical University, Chongqing, China.
Zhang Y; Chongqing Key Laboratory for Oral Diseases and Biomedical Sciences, The Affiliated Hospital of Stomatology of Chongqing Medical University, Chongqing, China.; Department of Pediatric Dentistry, The Affiliated Stomatology Hospital, Chongqing Medical University, Chongqing, China.
Huang X; Chongqing Key Laboratory for Oral Diseases and Biomedical Sciences, The Affiliated Hospital of Stomatology of Chongqing Medical University, Chongqing, China.; Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing, China.
Wang F; Chongqing Key Laboratory for Oral Diseases and Biomedical Sciences, The Affiliated Hospital of Stomatology of Chongqing Medical University, Chongqing, China.; Department of Pediatric Dentistry, The Affiliated Stomatology Hospital, Chongqing Medical University, Chongqing, China.
Li S; Chongqing Key Laboratory for Oral Diseases and Biomedical Sciences, The Affiliated Hospital of Stomatology of Chongqing Medical University, Chongqing, China.; Department of Pediatric Dentistry, The Affiliated Stomatology Hospital, Chongqing Medical University, Chongqing, China.
Yang Z; Chongqing Key Laboratory for Oral Diseases and Biomedical Sciences, The Affiliated Hospital of Stomatology of Chongqing Medical University, Chongqing, China.; Department of Pediatric Dentistry, The Affiliated Stomatology Hospital, Chongqing Medical University, Chongqing, China.
Liang F; Chongqing Key Laboratory for Oral Diseases and Biomedical Sciences, The Affiliated Hospital of Stomatology of Chongqing Medical University, Chongqing, China.; Department of Pediatric Dentistry, The Affiliated Stomatology Hospital, Chongqing Medical University, Chongqing, China.
Hu J; Chongqing Key Laboratory for Oral Diseases and Biomedical Sciences, The Affiliated Hospital of Stomatology of Chongqing Medical University, Chongqing, China.; Department of Pediatric Dentistry, The Affiliated Stomatology Hospital, Chongqing Medical University, Chongqing, China.
Jiang Y; Chongqing Key Laboratory for Oral Diseases and Biomedical Sciences, The Affiliated Hospital of Stomatology of Chongqing Medical University, Chongqing, China.; Department of Pediatric Dentistry, The Affiliated Stomatology Hospital, Chongqing Medical University, Chongqing, China.
Li Y; Chongqing Key Laboratory for Oral Diseases and Biomedical Sciences, The Affiliated Hospital of Stomatology of Chongqing Medical University, Chongqing, China.; Department of Pediatric Dentistry, The Affiliated Stomatology Hospital, Chongqing Medical University, Chongqing, China.
Zhou P; Chongqing Key Laboratory for Oral Diseases and Biomedical Sciences, The Affiliated Hospital of Stomatology of Chongqing Medical University, Chongqing, China.; Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing, China.
Luo W; Chongqing Key Laboratory for Oral Diseases and Biomedical Sciences, The Affiliated Hospital of Stomatology of Chongqing Medical University, Chongqing, China.; Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing, China.
Zhang H; Chongqing Key Laboratory for Oral Diseases and Biomedical Sciences, The Affiliated Hospital of Stomatology of Chongqing Medical University, Chongqing, China.; Department of Pediatric Dentistry, The Affiliated Stomatology Hospital, Chongqing Medical University, Chongqing, China.
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Źródło :
Cell proliferation [Cell Prolif] 2021 Apr; Vol. 54 (4), pp. e13016. Date of Electronic Publication: 2021 Mar 04.
Typ publikacji :
Journal Article
MeSH Terms :
Cell Differentiation*
Growth Differentiation Factor 2/*metabolism
Matrix Attachment Region Binding Proteins/*metabolism
Mesenchymal Stem Cells/*cytology
Odontoblasts/*cytology
Transcription Factors/*metabolism
Adenoviridae/genetics ; Animals ; Bone Regeneration ; Cell Adhesion ; Cell Line ; Cell Proliferation ; Cell Self Renewal ; Genetic Vectors/genetics ; Genetic Vectors/metabolism ; Growth Differentiation Factor 2/genetics ; Hydrogels/chemistry ; Incisor/cytology ; Matrix Attachment Region Binding Proteins/antagonists & inhibitors ; Matrix Attachment Region Binding Proteins/genetics ; Mesenchymal Stem Cells/metabolism ; Mice ; Mice, Inbred C57BL ; Odontoblasts/metabolism ; RNA Interference ; RNA, Small Interfering/metabolism ; Tissue Scaffolds/chemistry ; Transcription Factors/antagonists & inhibitors ; Transcription Factors/genetics
Czasopismo naukowe
Tytuł :
Potential Roles of Bone Morphogenetic Protein 9 in the Odontogenic Differentiation of Dental Pulp Cells.
Autorzy :
Li X; State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China; Department of Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Wang L; State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China; Department of Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Su Q; State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China; Department of Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Ye L; State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China; Department of Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Zhou X; State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China; Department of Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Zhang L; State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China; Department of Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Song D; State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China; Department of Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China. Electronic address: .
Huang D; State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China; Department of Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China. Electronic address: .
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Źródło :
Journal of endodontics [J Endod] 2021 Mar; Vol. 47 (3), pp. 436-443. Date of Electronic Publication: 2020 Oct 28.
Typ publikacji :
Journal Article
MeSH Terms :
Dental Pulp*
Growth Differentiation Factor 2*/genetics
Alkaline Phosphatase ; Animals ; Cell Differentiation ; Cell Proliferation ; Cells, Cultured ; Extracellular Matrix Proteins/genetics ; In Situ Hybridization, Fluorescence ; Odontoblasts ; Odontogenesis/genetics ; Phosphoproteins/genetics ; Rats
Czasopismo naukowe
Tytuł :
RORα is a critical checkpoint for T cell and ILC2 commitment in the embryonic thymus.
Autorzy :
Ferreira ACF; MRC Laboratory of Molecular Biology, Cambridge, UK. .
Szeto ACH; MRC Laboratory of Molecular Biology, Cambridge, UK.
Heycock MWD; MRC Laboratory of Molecular Biology, Cambridge, UK.
Clark PA; MRC Laboratory of Molecular Biology, Cambridge, UK.
Walker JA; MRC Laboratory of Molecular Biology, Cambridge, UK.; AstraZeneca, Aaron Klug Building, Cambridge, UK.
Crisp A; MRC Laboratory of Molecular Biology, Cambridge, UK.
Barlow JL; MRC Laboratory of Molecular Biology, Cambridge, UK.; Department of Biology, University of York, York, UK.
Kitching S; MRC Laboratory of Molecular Biology, Cambridge, UK.
Lim A; MRC Laboratory of Molecular Biology, Cambridge, UK.; Theolytics Ltd, Oxford, UK.
Gogoi M; MRC Laboratory of Molecular Biology, Cambridge, UK.
Berks R; MRC Laboratory of Molecular Biology, Cambridge, UK.
Daly M; MRC Laboratory of Molecular Biology, Cambridge, UK.
Jolin HE; MRC Laboratory of Molecular Biology, Cambridge, UK.
McKenzie ANJ; MRC Laboratory of Molecular Biology, Cambridge, UK. .
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Źródło :
Nature immunology [Nat Immunol] 2021 Feb; Vol. 22 (2), pp. 166-178. Date of Electronic Publication: 2021 Jan 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Differentiation*
Cell Lineage*
Immunity, Innate*
CD4-Positive T-Lymphocytes/*metabolism
CD8-Positive T-Lymphocytes/*metabolism
Nuclear Receptor Subfamily 1, Group F, Member 1/*metabolism
Thymocytes/*metabolism
Thymus Gland/*metabolism
Animals ; Basic-Leucine Zipper Transcription Factors/genetics ; Basic-Leucine Zipper Transcription Factors/metabolism ; CD4-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/immunology ; Cell Movement ; Cells, Cultured ; Coculture Techniques ; Female ; Gene Expression Regulation, Developmental ; Inhibitor of Differentiation Protein 2/genetics ; Inhibitor of Differentiation Protein 2/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Nuclear Receptor Subfamily 1, Group F, Member 1/genetics ; Organ Culture Techniques ; Phenotype ; Repressor Proteins/genetics ; Repressor Proteins/metabolism ; Signal Transduction ; Thymocytes/immunology ; Thymus Gland/embryology ; Thymus Gland/immunology ; Tumor Suppressor Proteins/genetics ; Tumor Suppressor Proteins/metabolism
Czasopismo naukowe
Tytuł :
Growth differentiation factor 5 in cartilage and osteoarthritis: A possible therapeutic candidate.
Autorzy :
Sun K; Department of Orthopedics, Tongji Medical College, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China.
Guo J; Department of Orthopedics, Tongji Medical College, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China.
Yao X; Department of Orthopedics, Tongji Medical College, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China.
Guo Z; Department of Orthopedics, Tongji Medical College, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China.
Guo F; Department of Orthopedics, Tongji Medical College, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China.
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Źródło :
Cell proliferation [Cell Prolif] 2021 Mar; Vol. 54 (3), pp. e12998. Date of Electronic Publication: 2021 Feb 01.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Chondrocytes/*metabolism
Growth Differentiation Factor 5/*metabolism
Osteoarthritis/*drug therapy
Osteoarthritis/*metabolism
Animals ; Cartilage Diseases/drug therapy ; Cartilage, Articular/drug effects ; Cartilage, Articular/metabolism ; Cell Differentiation/physiology ; Growth Differentiation Factor 5/genetics ; Growth Differentiation Factor 5/pharmacology ; Humans
Czasopismo naukowe
Tytuł :
Sialic acids in pancreatic cancer cells drive tumour-associated macrophage differentiation via the Siglec receptors Siglec-7 and Siglec-9.
Autorzy :
Rodriguez E; Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Molecular Cell Biology and Immunology, Cancer Center Amsterdam, Amsterdam Infection and Immunity Institute, Amsterdam, Netherlands.
Boelaars K; Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Molecular Cell Biology and Immunology, Cancer Center Amsterdam, Amsterdam Infection and Immunity Institute, Amsterdam, Netherlands.
Brown K; Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Molecular Cell Biology and Immunology, Cancer Center Amsterdam, Amsterdam Infection and Immunity Institute, Amsterdam, Netherlands.
Eveline Li RJ; Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Molecular Cell Biology and Immunology, Cancer Center Amsterdam, Amsterdam Infection and Immunity Institute, Amsterdam, Netherlands.
Kruijssen L; Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Molecular Cell Biology and Immunology, Cancer Center Amsterdam, Amsterdam Infection and Immunity Institute, Amsterdam, Netherlands.
Bruijns SCM; Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Molecular Cell Biology and Immunology, Cancer Center Amsterdam, Amsterdam Infection and Immunity Institute, Amsterdam, Netherlands.
van Ee T; Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Molecular Cell Biology and Immunology, Cancer Center Amsterdam, Amsterdam Infection and Immunity Institute, Amsterdam, Netherlands.
Schetters STT; Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Molecular Cell Biology and Immunology, Cancer Center Amsterdam, Amsterdam Infection and Immunity Institute, Amsterdam, Netherlands.
Crommentuijn MHW; Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Molecular Cell Biology and Immunology, Cancer Center Amsterdam, Amsterdam Infection and Immunity Institute, Amsterdam, Netherlands.
van der Horst JC; Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Molecular Cell Biology and Immunology, Cancer Center Amsterdam, Amsterdam Infection and Immunity Institute, Amsterdam, Netherlands.
van Grieken NCT; Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Pathology, Amsterdam, Netherlands.
van Vliet SJ; Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Molecular Cell Biology and Immunology, Cancer Center Amsterdam, Amsterdam Infection and Immunity Institute, Amsterdam, Netherlands.
Kazemier G; Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Surgery, Cancer Center Amsterdam, Amsterdam, Netherlands.
Giovannetti E; Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Medical Oncology, Cancer Center Amsterdam, Amsterdam, Netherlands.; Cancer Pharmacology Lab, AIRC Start-Up Unit, Fondazione Pisana per la Scienza, Pisa, Italy.
Garcia-Vallejo JJ; Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Molecular Cell Biology and Immunology, Cancer Center Amsterdam, Amsterdam Infection and Immunity Institute, Amsterdam, Netherlands.
van Kooyk Y; Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Molecular Cell Biology and Immunology, Cancer Center Amsterdam, Amsterdam Infection and Immunity Institute, Amsterdam, Netherlands. .
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Źródło :
Nature communications [Nat Commun] 2021 Feb 24; Vol. 12 (1), pp. 1270. Date of Electronic Publication: 2021 Feb 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antigens, CD/*metabolism
Antigens, Differentiation, Myelomonocytic/*metabolism
Lectins/*metabolism
Macrophages/*cytology
Macrophages/*metabolism
Monocytes/*cytology
Monocytes/*metabolism
Pancreas/*metabolism
Pancreatic Neoplasms/*metabolism
Sialic Acid Binding Immunoglobulin-like Lectins/*metabolism
Sialic Acids/*pharmacology
Antigens, CD/genetics ; Antigens, Differentiation, Myelomonocytic/genetics ; Cell Differentiation/drug effects ; Cell Line, Tumor ; Clustered Regularly Interspaced Short Palindromic Repeats/genetics ; Enzyme-Linked Immunosorbent Assay ; Flow Cytometry ; Humans ; Lectins/genetics ; Macrophages/drug effects ; Monocytes/drug effects ; Phosphorylation/drug effects ; Sialic Acid Binding Immunoglobulin-like Lectins/genetics
SCR Disease Name :
Pancreatic Carcinoma
Czasopismo naukowe
Tytuł :
BMP9 exhibits dual and coupled roles in inducing osteogenic and angiogenic differentiation of mesenchymal stem cells.
Autorzy :
Xiao H; Department of Orthopaedic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Wang X; Department of Orthopaedic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Wang C; Department of Computational and Applied Mathematics, Rice University, Houston, TX 77005, U.S.A.
Dai G; Department of Orthopaedic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Zhu Z; Department of Orthopaedic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Gao S; Department of Orthopaedic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
He B; Key Laboratory for Biochemistry and Molecular Pharmacology of Chongqing, Chongqing Medical University, Chongqing 400016, China.
Liao J; Department of Orthopaedic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Huang W; Department of Orthopaedic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
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Źródło :
Bioscience reports [Biosci Rep] 2020 Jun 26; Vol. 40 (6).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Differentiation*
Neovascularization, Physiologic*
Osteogenesis*
Growth Differentiation Factor 2/*metabolism
Mesenchymal Stem Cells/*metabolism
Animals ; Gene Expression Regulation ; Growth Differentiation Factor 2/genetics ; HEK293 Cells ; Humans ; Mesenchymal Stem Cell Transplantation ; Mice ; Mice, Nude ; Platelet Endothelial Cell Adhesion Molecule-1/genetics ; Platelet Endothelial Cell Adhesion Molecule-1/metabolism ; Signal Transduction ; Vascular Endothelial Growth Factor A/genetics ; Vascular Endothelial Growth Factor A/metabolism
Czasopismo naukowe
Tytuł :
Endothelial BMPR2 Loss Drives a Proliferative Response to BMP (Bone Morphogenetic Protein) 9 via Prolonged Canonical Signaling.
Autorzy :
Theilmann AL; Department of Biomedical and Molecular Sciences (A.L.T., L.G.H., L.R.H., M.K.M.W., D.V.C., J.L.M., D.H.M., M.L.O.), Queen's University, Kingston, Canada.
Hawke LG; Department of Biomedical and Molecular Sciences (A.L.T., L.G.H., L.R.H., M.K.M.W., D.V.C., J.L.M., D.H.M., M.L.O.), Queen's University, Kingston, Canada.
Hilton LR; Department of Biomedical and Molecular Sciences (A.L.T., L.G.H., L.R.H., M.K.M.W., D.V.C., J.L.M., D.H.M., M.L.O.), Queen's University, Kingston, Canada.
Whitford MKM; Department of Biomedical and Molecular Sciences (A.L.T., L.G.H., L.R.H., M.K.M.W., D.V.C., J.L.M., D.H.M., M.L.O.), Queen's University, Kingston, Canada.
Cole DV; Department of Biomedical and Molecular Sciences (A.L.T., L.G.H., L.R.H., M.K.M.W., D.V.C., J.L.M., D.H.M., M.L.O.), Queen's University, Kingston, Canada.
Mackeil JL; Department of Biomedical and Molecular Sciences (A.L.T., L.G.H., L.R.H., M.K.M.W., D.V.C., J.L.M., D.H.M., M.L.O.), Queen's University, Kingston, Canada.
Dunham-Snary KJ; Department of Medicine (K.J.D.-S., J.M., P.D.J., S.L.A., M.L.O.), Queen's University, Kingston, Canada.
Mewburn J; Department of Medicine (K.J.D.-S., J.M., P.D.J., S.L.A., M.L.O.), Queen's University, Kingston, Canada.
James PD; Department of Medicine (K.J.D.-S., J.M., P.D.J., S.L.A., M.L.O.), Queen's University, Kingston, Canada.
Maurice DH; Department of Biomedical and Molecular Sciences (A.L.T., L.G.H., L.R.H., M.K.M.W., D.V.C., J.L.M., D.H.M., M.L.O.), Queen's University, Kingston, Canada.
Archer SL; Department of Medicine (K.J.D.-S., J.M., P.D.J., S.L.A., M.L.O.), Queen's University, Kingston, Canada.
Ormiston ML; Department of Surgery (M.L.O.), Queen's University, Kingston, Canada.
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Źródło :
Arteriosclerosis, thrombosis, and vascular biology [Arterioscler Thromb Vasc Biol] 2020 Nov; Vol. 40 (11), pp. 2605-2618. Date of Electronic Publication: 2020 Oct 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Bone Morphogenetic Protein Receptors, Type II/*deficiency
Cell Proliferation/*drug effects
Endothelial Cells/*drug effects
Growth Differentiation Factor 2/*pharmacology
Pulmonary Arterial Hypertension/*drug therapy
Adult ; Aged ; Animals ; Bone Morphogenetic Protein Receptors, Type II/genetics ; Case-Control Studies ; Cells, Cultured ; Endothelial Cells/metabolism ; Endothelial Cells/pathology ; Female ; Growth Differentiation Factor 2/toxicity ; Humans ; Inhibitor of Differentiation Proteins/genetics ; Inhibitor of Differentiation Proteins/metabolism ; Male ; Mice, Inbred C57BL ; Mice, Knockout ; Middle Aged ; Pulmonary Arterial Hypertension/genetics ; Pulmonary Arterial Hypertension/metabolism ; Pulmonary Arterial Hypertension/pathology ; Signal Transduction ; Young Adult
Czasopismo naukowe
Tytuł :
Effect of cAMP Signaling Regulation in Osteogenic Differentiation of Adipose-Derived Mesenchymal Stem Cells.
Autorzy :
Rumiński S; Department of Histology and Embryology, Center for Biostructure Research, Medical University of Warsaw, 02-004 Warsaw, Poland.; Postgraduate School of Molecular Medicine, Medical University of Warsaw, 02-091 Warsaw, Poland.
Kalaszczyńska I; Department of Histology and Embryology, Center for Biostructure Research, Medical University of Warsaw, 02-004 Warsaw, Poland.; Laboratory for Cell Research and Application, Medical University of Warsaw, Warsaw 02-097, Poland.
Lewandowska-Szumieł M; Department of Histology and Embryology, Center for Biostructure Research, Medical University of Warsaw, 02-004 Warsaw, Poland.; Laboratory for Cell Research and Application, Medical University of Warsaw, Warsaw 02-097, Poland.
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Źródło :
Cells [Cells] 2020 Jun 30; Vol. 9 (7). Date of Electronic Publication: 2020 Jun 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Differentiation*
Signal Transduction*
Adipose Tissue/*cytology
Cyclic AMP/*metabolism
Mesenchymal Stem Cells/*metabolism
Osteoblasts/*metabolism
Cells, Cultured ; Core Binding Factor Alpha 1 Subunit/genetics ; Core Binding Factor Alpha 1 Subunit/metabolism ; Cyclic AMP-Dependent Protein Kinases/genetics ; Cyclic AMP-Dependent Protein Kinases/metabolism ; Humans ; Inhibitor of Differentiation Protein 2/genetics ; Inhibitor of Differentiation Protein 2/metabolism ; Integrin-Binding Sialoprotein/genetics ; Integrin-Binding Sialoprotein/metabolism ; Mesenchymal Stem Cells/cytology ; Osteoblasts/cytology ; Osteocalcin/genetics ; Osteocalcin/metabolism ; Sp7 Transcription Factor/genetics ; Sp7 Transcription Factor/metabolism ; Up-Regulation
Czasopismo naukowe
Tytuł :
Dectin-1 Stimulation of Hematopoietic Stem and Progenitor Cells Occurs In Vivo and Promotes Differentiation Toward Trained Macrophages via an Indirect Cell-Autonomous Mechanism.
Autorzy :
Bono C; Departamento de Microbiología y Ecología, Universitat de València, Burjassot, Spain.; Estructura de Recerca Interdisciplinar en Biotecnologia i Biomedicina (ERI BIOTECMED), Universitat de València, Burjassot, Spain.
Martínez A; Departamento de Microbiología y Ecología, Universitat de València, Burjassot, Spain.; Estructura de Recerca Interdisciplinar en Biotecnologia i Biomedicina (ERI BIOTECMED), Universitat de València, Burjassot, Spain.
Megías J; Departamento de Patología, Universitat de València, Valencia, Spain.
Gozalbo D; Departamento de Microbiología y Ecología, Universitat de València, Burjassot, Spain.; Estructura de Recerca Interdisciplinar en Biotecnologia i Biomedicina (ERI BIOTECMED), Universitat de València, Burjassot, Spain.
Yáñez A; Departamento de Microbiología y Ecología, Universitat de València, Burjassot, Spain.; Estructura de Recerca Interdisciplinar en Biotecnologia i Biomedicina (ERI BIOTECMED), Universitat de València, Burjassot, Spain.
Gil ML; Departamento de Microbiología y Ecología, Universitat de València, Burjassot, Spain .; Estructura de Recerca Interdisciplinar en Biotecnologia i Biomedicina (ERI BIOTECMED), Universitat de València, Burjassot, Spain.
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Źródło :
MBio [mBio] 2020 Jun 23; Vol. 11 (3). Date of Electronic Publication: 2020 Jun 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Differentiation*
Hematopoietic Stem Cells/*cytology
Lectins, C-Type/*metabolism
Macrophages/*cytology
Stem Cells/*cytology
Animals ; Candida albicans/immunology ; Candidiasis/immunology ; Female ; Hematopoietic Stem Cells/drug effects ; Immunity, Innate ; Lectins, C-Type/genetics ; Macrophages/immunology ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Myeloid Differentiation Factor 88/metabolism ; Signal Transduction ; Stem Cells/drug effects ; Toll-Like Receptor 2/immunology ; beta-Glucans/administration & dosage
SCR Disease Name :
Systemic candidiasis
Czasopismo naukowe
Tytuł :
Establishment of an organ culture system to induce Sertoli cell differentiation from undifferentiated mouse gonads.
Autorzy :
Hasegawa C; Department of Animal Science, Graduate School of Agricultural Science, Kobe University, 1-1 Rokkodai, Nada-ku, Kobe, Hyogo 657-8501, Japan.
Yokoyama T; Department of Animal Science, Graduate School of Agricultural Science, Kobe University, 1-1 Rokkodai, Nada-ku, Kobe, Hyogo 657-8501, Japan.
Umemura Y; Department of Animal Science, Graduate School of Agricultural Science, Kobe University, 1-1 Rokkodai, Nada-ku, Kobe, Hyogo 657-8501, Japan.
Kawanishi K; Department of Animal Science, Graduate School of Agricultural Science, Kobe University, 1-1 Rokkodai, Nada-ku, Kobe, Hyogo 657-8501, Japan.
Miura Y; Department of Animal Science, Graduate School of Agricultural Science, Kobe University, 1-1 Rokkodai, Nada-ku, Kobe, Hyogo 657-8501, Japan.
Takada N; Department of Animal Science, Graduate School of Agricultural Science, Kobe University, 1-1 Rokkodai, Nada-ku, Kobe, Hyogo 657-8501, Japan.
Ohno S; Department of Animal Science, Graduate School of Agricultural Science, Kobe University, 1-1 Rokkodai, Nada-ku, Kobe, Hyogo 657-8501, Japan.
Onaru K; Department of Animal Science, Graduate School of Agricultural Science, Kobe University, 1-1 Rokkodai, Nada-ku, Kobe, Hyogo 657-8501, Japan.
Omotehara T; Department of Anatomy, Tokyo Medical University, 6-1-1 Shinjuku, Shinjuku, Tokyo 160-8402, Japan.
Hirano T; Division of Drug and Structural Research, Life Science Research Center, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.
Mantani Y; Department of Animal Science, Graduate School of Agricultural Science, Kobe University, 1-1 Rokkodai, Nada-ku, Kobe, Hyogo 657-8501, Japan.
Miki T; Departments of Anatomy and Neurobiology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kagawa 761-0793, Japan.
Hoshi N; Department of Animal Science, Graduate School of Agricultural Science, Kobe University, 1-1 Rokkodai, Nada-ku, Kobe, Hyogo 657-8501, Japan.
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Źródło :
The Journal of veterinary medical science [J Vet Med Sci] 2020 Apr 09; Vol. 82 (4), pp. 414-421. Date of Electronic Publication: 2020 Feb 21.
Typ publikacji :
Journal Article
MeSH Terms :
Cell Differentiation*
Sertoli Cells*
Organ Culture Techniques/*veterinary
Testis/*embryology
Animals ; Anti-Mullerian Hormone/metabolism ; Embryo, Mammalian ; Female ; Male ; Mice, Inbred ICR ; RNA, Messenger ; SOX9 Transcription Factor/metabolism ; Sex Differentiation ; Sex-Determining Region Y Protein/genetics ; Sex-Determining Region Y Protein/metabolism ; Testis/cytology
Czasopismo naukowe
Tytuł :
Enhanced differentiation of human dopaminergic neuronal cell model for preclinical translational research in Parkinson's disease.
Autorzy :
Harischandra DS; Department of Biomedical Sciences, Parkinson's Disorder Research Program, Iowa State University, Ames, IA, USA.
Rokad D; Department of Biomedical Sciences, Parkinson's Disorder Research Program, Iowa State University, Ames, IA, USA.
Ghaisas S; Department of Biomedical Sciences, Parkinson's Disorder Research Program, Iowa State University, Ames, IA, USA.
Verma S; Department of Biomedical Sciences, Parkinson's Disorder Research Program, Iowa State University, Ames, IA, USA.
Robertson A; Department of Biomedical Sciences, Parkinson's Disorder Research Program, Iowa State University, Ames, IA, USA.
Jin H; Department of Biomedical Sciences, Parkinson's Disorder Research Program, Iowa State University, Ames, IA, USA.
Anantharam V; Department of Biomedical Sciences, Parkinson's Disorder Research Program, Iowa State University, Ames, IA, USA.
Kanthasamy A; Department of Biomedical Sciences, Parkinson's Disorder Research Program, Iowa State University, Ames, IA, USA.
Kanthasamy AG; Department of Biomedical Sciences, Parkinson's Disorder Research Program, Iowa State University, Ames, IA, USA. Electronic address: .
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Źródło :
Biochimica et biophysica acta. Molecular basis of disease [Biochim Biophys Acta Mol Basis Dis] 2020 Apr 01; Vol. 1866 (4), pp. 165533. Date of Electronic Publication: 2019 Aug 20.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Cell Differentiation*
Models, Neurological*
Translational Medical Research*
Dopaminergic Neurons/*metabolism
Neural Stem Cells/*metabolism
Parkinson Disease/*metabolism
Antigens, Differentiation/biosynthesis ; Cell Line ; Dopaminergic Neurons/pathology ; Humans ; Neural Stem Cells/pathology ; Parkinson Disease/pathology ; Parkinson Disease/therapy
Czasopismo naukowe
Tytuł :
Bone morphogenetic protein 2 promotes human trophoblast cell invasion and endothelial-like tube formation through ID1-mediated upregulation of IGF binding protein-3.
Autorzy :
Zhao HJ; Department of Cardiology, Shandong Provincial Hospital affiliated to Shandong University, Jinan, P.R. China.; Department of Obstetrics and Gynaecology, BC Children's Hospital Research Institute, University of British Columbia, Vancouver, BC, Canada.
Klausen C; Department of Obstetrics and Gynaecology, BC Children's Hospital Research Institute, University of British Columbia, Vancouver, BC, Canada.
Zhu H; Department of Obstetrics and Gynaecology, BC Children's Hospital Research Institute, University of British Columbia, Vancouver, BC, Canada.
Chang HM; Department of Obstetrics and Gynaecology, BC Children's Hospital Research Institute, University of British Columbia, Vancouver, BC, Canada.
Li Y; School of Medicine, Shandong University, Jinan, China.; Center for Reproductive Medicine, Shandong University, Jinan, China.; The Key Laboratory of Reproductive Endocrinology, Ministry of Education, Jinan, China.; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Jinan, China.
Leung PCK; Department of Obstetrics and Gynaecology, BC Children's Hospital Research Institute, University of British Columbia, Vancouver, BC, Canada.
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Źródło :
FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2020 Feb; Vol. 34 (2), pp. 3151-3164. Date of Electronic Publication: 2020 Jan 03.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Differentiation*
Cell Movement*
Bone Morphogenetic Protein 2/*pharmacology
Endothelial Cells/*metabolism
Trophoblasts/*metabolism
Cell Line ; Cells, Cultured ; Endothelial Cells/cytology ; Humans ; Inhibitor of Differentiation Protein 1/genetics ; Inhibitor of Differentiation Protein 1/metabolism ; Insulin-Like Growth Factor Binding Protein 3/genetics ; Insulin-Like Growth Factor Binding Protein 3/metabolism ; Placenta Growth Factor/metabolism ; Trophoblasts/cytology ; Trophoblasts/drug effects ; Trophoblasts/physiology ; Up-Regulation
Czasopismo naukowe
Tytuł :
Morphological characterization of pirarucu Arapaima gigas (Schinz, 1822) gonadal differentiation.
Autorzy :
da Costa Amaral A; Programa de Pós-graduação em Ciências Pesqueiras nos Trópicos, Universidade Federal do Amazonas, Manaus, Brazil.
Lima AF; Embrapa Pesca e Aquicultura, Palmas, Brazil.
Ganeco-Kirschnik LN; Embrapa Pesca e Aquicultura, Palmas, Brazil.
de Almeida FL; Embrapa Amazônia Ocidental, Manaus, Brazil.
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Źródło :
Journal of morphology [J Morphol] 2020 Apr; Vol. 281 (4-5), pp. 491-499. Date of Electronic Publication: 2020 Mar 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Sex Differentiation*
Fishes/*anatomy & histology
Gonads/*anatomy & histology
Animals ; Cell Differentiation ; Female ; Fishes/growth & development ; Fishes/physiology ; Male ; Ovary/anatomy & histology ; Ovary/cytology ; Testis/anatomy & histology ; Testis/growth & development ; Vitellogenesis
Czasopismo naukowe
Tytuł :
M2 differentiation of MonoMac-1 cell line induced by M-CSF and glucocorticoid pathways.
Autorzy :
Vakili S; Center for Neurovirology, Department of Neuroscience, Temple University School of Medicine, Philadelphia, Pennsylvania.
Fischer T; Center for Neurovirology, Department of Neuroscience, Temple University School of Medicine, Philadelphia, Pennsylvania.
Rappaport J; Center for Neurovirology, Department of Neuroscience, Temple University School of Medicine, Philadelphia, Pennsylvania.
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Źródło :
Journal of cellular physiology [J Cell Physiol] 2020 Oct; Vol. 235 (10), pp. 7383-7391. Date of Electronic Publication: 2020 Feb 13.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Cell Differentiation/*physiology
Glucocorticoids/*metabolism
Macrophage Colony-Stimulating Factor/*metabolism
Signal Transduction/*physiology
Antigens, CD/metabolism ; Antigens, Differentiation, Myelomonocytic/metabolism ; Cell Differentiation/drug effects ; Cell Line ; Cell Lineage/drug effects ; Cell Lineage/physiology ; Genes, fms/genetics ; Humans ; Leukemia, Myeloid, Acute/genetics ; Leukemia, Myeloid, Acute/metabolism ; Lipopolysaccharides/pharmacology ; Macrophages/drug effects ; Macrophages/metabolism ; Monocytes/drug effects ; Monocytes/metabolism ; Receptors, Cell Surface/metabolism ; Receptors, IgG/metabolism ; Signal Transduction/drug effects
Czasopismo naukowe
Tytuł :
MEK5/ERK5 signaling mediates IL-4-induced M2 macrophage differentiation through regulation of c-Myc expression.
Autorzy :
Luiz JPM; Center for Research in Inflammatory Diseases and Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.
Toller-Kawahisa JE; Center for Research in Inflammatory Diseases and Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.
Viacava PR; Center for Research in Inflammatory Diseases and Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.
Nascimento DC; Center for Research in Inflammatory Diseases and Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.
Pereira PT; Center for Research in Inflammatory Diseases and Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.
Saraiva AL; Center for Research in Inflammatory Diseases and Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.
Prado DS; Center for Research in Inflammatory Diseases and Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.
LeBert M; CNRS, UMR7355, Orléans, France.; Experimental and Molecular Immunology and Neurogenetics, University of Orléans, Orléans, France.
Giurisato E; Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom.
Tournier C; Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom.
Cunha TM; Center for Research in Inflammatory Diseases and Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.
Cunha FQ; Center for Research in Inflammatory Diseases and Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.
Quesniaux V; CNRS, UMR7355, Orléans, France.; Experimental and Molecular Immunology and Neurogenetics, University of Orléans, Orléans, France.
Ryffel B; CNRS, UMR7355, Orléans, France.; Experimental and Molecular Immunology and Neurogenetics, University of Orléans, Orléans, France.
Alves-Filho JC; Center for Research in Inflammatory Diseases and Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.
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Źródło :
Journal of leukocyte biology [J Leukoc Biol] 2020 Oct; Vol. 108 (4), pp. 1215-1223. Date of Electronic Publication: 2020 Aug 03.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Differentiation/*immunology
Interleukin-4/*immunology
MAP Kinase Kinase 5/*immunology
MAP Kinase Signaling System/*immunology
Macrophages/*immunology
Mitogen-Activated Protein Kinase 7/*immunology
Proto-Oncogene Proteins c-myc/*immunology
Animals ; Antigens, Differentiation/genetics ; Antigens, Differentiation/immunology ; Cell Differentiation/genetics ; Gene Expression Regulation/immunology ; Interleukin-4/genetics ; MAP Kinase Kinase 5/genetics ; MAP Kinase Signaling System/genetics ; Mice ; Mice, Inbred BALB C ; Mice, Knockout ; Mitogen-Activated Protein Kinase 7/genetics ; Proto-Oncogene Proteins c-myc/genetics ; STAT3 Transcription Factor/genetics ; STAT3 Transcription Factor/immunology ; STAT6 Transcription Factor/genetics ; STAT6 Transcription Factor/immunology
Czasopismo naukowe
Tytuł :
Anti-CD6 mAbs for the treatment of psoriasis.
Autorzy :
Dogra S; Department of Dermatology, Venereology, and Leprology, Postgraduate Institute of Medical Education & Research , Chandigarh, India.
D S; Biocon Biologics , Bangalore, India.
Rajagopalan M; Department of Dermatology, Apollo Hospital , Chennai, India.
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Źródło :
Expert opinion on biological therapy [Expert Opin Biol Ther] 2020 Oct; Vol. 20 (10), pp. 1215-1222. Date of Electronic Publication: 2020 Jun 09.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Antibodies, Monoclonal/*therapeutic use
Antigens, CD/*immunology
Antigens, Differentiation, T-Lymphocyte/*immunology
Psoriasis/*drug therapy
Antibodies, Monoclonal, Humanized/therapeutic use ; Antigens, CD/physiology ; Antigens, Differentiation, T-Lymphocyte/physiology ; Autoimmune Diseases/drug therapy ; Cell Differentiation ; Cyclosporine/therapeutic use ; Humans ; Methotrexate/therapeutic use ; Psoriasis/etiology ; Psoriasis/immunology ; Tumor Necrosis Factor-alpha/therapeutic use
Czasopismo naukowe
Tytuł :
A Simple Differentiation Protocol for Generation of Induced Pluripotent Stem Cell-Derived Basal Forebrain-Like Cholinergic Neurons for Alzheimer's Disease and Frontotemporal Dementia Disease Modeling.
Autorzy :
Muñoz SS; Illawarra Health and Medical Research Institute, Wollongong, NSW 2522, Australia.; School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, NSW 2522, Australia.
Engel M; Illawarra Health and Medical Research Institute, Wollongong, NSW 2522, Australia.; School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, NSW 2522, Australia.
Balez R; Illawarra Health and Medical Research Institute, Wollongong, NSW 2522, Australia.; School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, NSW 2522, Australia.
Do-Ha D; Illawarra Health and Medical Research Institute, Wollongong, NSW 2522, Australia.; School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, NSW 2522, Australia.
Cabral-da-Silva MC; Illawarra Health and Medical Research Institute, Wollongong, NSW 2522, Australia.; School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, NSW 2522, Australia.
Hernández D; Department of Anatomy & Neuroscience, University of Melbourne, Parkville, VIC 3010, Australia.; Department of Surgery, University of Melbourne, Parkville, VIC 3010, Australia.; Centre for Eye Research Australia, Royal Victoria Eye and Ear Hospital, Melbourne, VIC 3002, Australia.
Berg T; Illawarra Health and Medical Research Institute, Wollongong, NSW 2522, Australia.; School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, NSW 2522, Australia.
Fifita JA; Centre for Motor Neuron Disease Research, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, NSW 2190, Australia.
Grima N; Centre for Motor Neuron Disease Research, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, NSW 2190, Australia.
Yang S; Centre for Motor Neuron Disease Research, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, NSW 2190, Australia.
Blair IP; Centre for Motor Neuron Disease Research, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, NSW 2190, Australia.
Nicholson G; Concord Repatriation General Hospital, University of Sydney ANZAC Research Institute, Sydney, NSW 2006, Australia.
Cook AL; Wicking Dementia Research and Education Centre, University of Tasmania, Hobart, TAS 7001, Australia.
Hewitt AW; Department of Surgery, University of Melbourne, Parkville, VIC 3010, Australia.; Centre for Eye Research Australia, Royal Victoria Eye and Ear Hospital, Melbourne, VIC 3002, Australia.; School of Medicine, Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS 7000, Australia.
Pébay A; Department of Anatomy & Neuroscience, University of Melbourne, Parkville, VIC 3010, Australia.; Department of Surgery, University of Melbourne, Parkville, VIC 3010, Australia.; Centre for Eye Research Australia, Royal Victoria Eye and Ear Hospital, Melbourne, VIC 3002, Australia.
Ooi L; Illawarra Health and Medical Research Institute, Wollongong, NSW 2522, Australia.; School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, NSW 2522, Australia.
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Źródło :
Cells [Cells] 2020 Sep 02; Vol. 9 (9). Date of Electronic Publication: 2020 Sep 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Differentiation/*drug effects
Cholinergic Neurons/*drug effects
Culture Media/*pharmacology
Embryoid Bodies/*drug effects
Induced Pluripotent Stem Cells/*drug effects
Primary Cell Culture/*methods
Alzheimer Disease/genetics ; Alzheimer Disease/metabolism ; Alzheimer Disease/pathology ; Amyotrophic Lateral Sclerosis/genetics ; Amyotrophic Lateral Sclerosis/metabolism ; Amyotrophic Lateral Sclerosis/pathology ; Basal Forebrain/metabolism ; Basal Forebrain/pathology ; Benzamides/pharmacology ; Brain-Derived Neurotrophic Factor/pharmacology ; Cell Line ; Cholinergic Neurons/cytology ; Cholinergic Neurons/metabolism ; Culture Media/chemistry ; Dioxoles/pharmacology ; Embryoid Bodies/cytology ; Embryoid Bodies/metabolism ; Female ; Fibroblast Growth Factor 2/pharmacology ; Frontotemporal Dementia/genetics ; Frontotemporal Dementia/metabolism ; Frontotemporal Dementia/pathology ; Growth Differentiation Factor 2/pharmacology ; Hedgehog Proteins/pharmacology ; Humans ; Induced Pluripotent Stem Cells/cytology ; Induced Pluripotent Stem Cells/metabolism ; Male ; Models, Biological ; Nerve Growth Factor/pharmacology ; Patch-Clamp Techniques ; Pyrazoles/pharmacology ; Pyrimidines/pharmacology ; Transforming Growth Factor beta/pharmacology
Czasopismo naukowe
Tytuł :
Itolizumab, an anti-CD6 monoclonal antibody, as a potential treatment for COVID-19 complications.
Autorzy :
Loganathan S; Clinical Sciences, Clinical Development and Medical Affairs, Biocon Biologics India Ltd , Bengaluru, India.
Athalye SN; Clinical Sciences, Clinical Development and Medical Affairs, Biocon Biologics India Ltd , Bengaluru, India.
Joshi SR; Consultant, Joshi Clinic and Lilavati Hospital , Mumbai, India.
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Źródło :
Expert opinion on biological therapy [Expert Opin Biol Ther] 2020 Sep; Vol. 20 (9), pp. 1025-1031. Date of Electronic Publication: 2020 Jul 29.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Betacoronavirus*
Antibodies, Monoclonal, Humanized/*therapeutic use
Antigens, CD/*immunology
Antigens, Differentiation, T-Lymphocyte/*immunology
Coronavirus Infections/*drug therapy
Coronavirus Infections/*immunology
Pneumonia, Viral/*drug therapy
Pneumonia, Viral/*immunology
Antibodies, Monoclonal, Humanized/pharmacology ; COVID-19 ; Cell Differentiation/drug effects ; Cell Differentiation/physiology ; Cell Proliferation/drug effects ; Cell Proliferation/physiology ; Cytokines/antagonists & inhibitors ; Cytokines/immunology ; Humans ; Lymphocyte Activation/drug effects ; Lymphocyte Activation/physiology ; Pandemics ; SARS-CoV-2 ; T-Lymphocytes/drug effects ; T-Lymphocytes/immunology ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Dose-Response Tendon-Specific Markers Induction by Growth Differentiation Factor-5 in Human Bone Marrow and Umbilical Cord Mesenchymal Stem Cells.
Autorzy :
Ciardulli MC; Department of Medicine, Surgery and Dentistry 'Scuola Medica Salernitana', University of Salerno, Via S. Allende, 1, 84084 Baronissi (SA), Italy.
Marino L; Department of Medicine, Surgery and Dentistry 'Scuola Medica Salernitana', University of Salerno, Via S. Allende, 1, 84084 Baronissi (SA), Italy.
Lamparelli EP; Department of Medicine, Surgery and Dentistry 'Scuola Medica Salernitana', University of Salerno, Via S. Allende, 1, 84084 Baronissi (SA), Italy.
Guida M; Department of Neuroscience and Reproductive Science and Dentistry, University of Naples 'Federico II', Via Pansini, 5, 80131 Naples, Italy.
Forsyth NR; Guy Hilton Research Centre, School of Pharmacy and Bioengineering, Keele University, Stoke-on-Trent ST4 7QB, UK.
Selleri C; Department of Medicine, Surgery and Dentistry 'Scuola Medica Salernitana', University of Salerno, Via S. Allende, 1, 84084 Baronissi (SA), Italy.
Della Porta G; Department of Medicine, Surgery and Dentistry 'Scuola Medica Salernitana', University of Salerno, Via S. Allende, 1, 84084 Baronissi (SA), Italy.
Maffulli N; Department of Medicine, Surgery and Dentistry 'Scuola Medica Salernitana', University of Salerno, Via S. Allende, 1, 84084 Baronissi (SA), Italy.; Mile End Hospital, Centre for Sports and Exercise Medicine, Queen Mary University of London, Barts and the London School of Medicine and Dentistry, 275 Bancroft Road, London E1 4DG, UK.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Aug 17; Vol. 21 (16). Date of Electronic Publication: 2020 Aug 17.
Typ publikacji :
Journal Article
MeSH Terms :
Bone Marrow Cells/*metabolism
Growth Differentiation Factor 5/*pharmacology
Mesenchymal Stem Cells/*metabolism
Tenocytes/*metabolism
Adult ; Basic Helix-Loop-Helix Transcription Factors/genetics ; Basic Helix-Loop-Helix Transcription Factors/metabolism ; Bone Marrow Cells/cytology ; Bone Marrow Cells/drug effects ; Cell Differentiation ; Cells, Cultured ; Collagen/genetics ; Collagen/metabolism ; Decorin/genetics ; Decorin/metabolism ; Female ; Humans ; Interleukins/genetics ; Interleukins/metabolism ; Male ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Mesenchymal Stem Cells/cytology ; Mesenchymal Stem Cells/drug effects ; Tenascin/genetics ; Tenascin/metabolism ; Tenocytes/cytology ; Umbilical Cord/cytology
Czasopismo naukowe
Tytuł :
MicroRNA‑93 contributes to the suppression of lung inflammatory responses in LPS‑induced acute lung injury in mice via the TLR4/MyD88/NF‑κB signaling pathway.
Autorzy :
Gao H; Department of Emergency, West China Second University Hospital, Sichuan University, Chengdu, Sichuan 610000, P.R. China.
Xiao D; Department of Emergency, West China Second University Hospital, Sichuan University, Chengdu, Sichuan 610000, P.R. China.
Gao L; Laboratory of Molecular Translational Medicine, Center for Translational Medicine, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, Sichuan 610000, P.R. China.
Li X; Department of Emergency, West China Second University Hospital, Sichuan University, Chengdu, Sichuan 610000, P.R. China.
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Źródło :
International journal of molecular medicine [Int J Mol Med] 2020 Aug; Vol. 46 (2), pp. 561-570. Date of Electronic Publication: 2020 May 19.
Typ publikacji :
Journal Article
MeSH Terms :
Acute Lung Injury/*chemically induced
Acute Lung Injury/*metabolism
Lipopolysaccharides/*toxicity
MicroRNAs/*metabolism
Myeloid Differentiation Factor 88/*metabolism
NF-kappa B/*metabolism
Toll-Like Receptor 4/*metabolism
Acute Lung Injury/genetics ; Animals ; Blotting, Western ; Cell Differentiation/genetics ; Cell Differentiation/physiology ; Immunohistochemistry ; Interleukin-1beta/metabolism ; Interleukin-6/metabolism ; Male ; Mice ; Mice, Inbred BALB C ; MicroRNAs/genetics ; Myeloid Differentiation Factor 88/genetics ; NF-kappa B/genetics ; RAW 264.7 Cells ; Signal Transduction/genetics ; Signal Transduction/physiology ; Toll-Like Receptor 4/genetics ; Tumor Necrosis Factor-alpha/metabolism
Czasopismo naukowe

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