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Tytuł:
A Comparative Biochemical and Pathological Evaluation of Brain Samples from Knock-In Murine Models of Gaucher Disease.
Autorzy:
Furderer ML; Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA.
Berhe B; Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA.
Chen TC; Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA.
Wincovitch S; Advanced Imaging & Analysis Core, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Jiang X; Washington University Metabolomics Facility, Washington University School of Medicine, St. Louis, MO 63110, USA.
Tayebi N; Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA.
Sidransky E; Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA.
Han TU; Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Feb 02; Vol. 25 (3). Date of Electronic Publication: 2024 Feb 02.
Typ publikacji:
Journal Article
MeSH Terms:
Gaucher Disease*/genetics
Gaucher Disease*/pathology
Psychosine/*analogs & derivatives
Mice ; Humans ; Animals ; Aged ; Glucosylceramidase/genetics ; Glucosylceramidase/metabolism ; Disease Models, Animal ; Brain/metabolism ; alpha-Synuclein/genetics ; alpha-Synuclein/metabolism ; Mutation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Chicoric Acid Ameliorated Beta-Amyloid Pathology and Enhanced Expression of Synaptic-Function-Related Markers via L1CAM in Alzheimer's Disease Models.
Autorzy:
Wang R; National-Local Joint Engineering Research Center for Drug-Research and Development (R&D) of Neurodegenerative Diseases, Dalian Medical University, Dalian 116044, China.; School of Integrated Chinese and Western Medicine, Dalian Medical University, Dalian 116044, China.
Kang S; National-Local Joint Engineering Research Center for Drug-Research and Development (R&D) of Neurodegenerative Diseases, Dalian Medical University, Dalian 116044, China.; School of Basic Medical Sciences, Dalian Medical University, Dalian 116044, China.
Zhao Z; National-Local Joint Engineering Research Center for Drug-Research and Development (R&D) of Neurodegenerative Diseases, Dalian Medical University, Dalian 116044, China.; School of Integrated Chinese and Western Medicine, Dalian Medical University, Dalian 116044, China.
Jin L; National-Local Joint Engineering Research Center for Drug-Research and Development (R&D) of Neurodegenerative Diseases, Dalian Medical University, Dalian 116044, China.
Cui X; National-Local Joint Engineering Research Center for Drug-Research and Development (R&D) of Neurodegenerative Diseases, Dalian Medical University, Dalian 116044, China.
Chen L; National-Local Joint Engineering Research Center for Drug-Research and Development (R&D) of Neurodegenerative Diseases, Dalian Medical University, Dalian 116044, China.
Schachner M; Keck Center for Collaborative Neuroscience and Department of Cell Biology and Neuroscience, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA.
Li S; National-Local Joint Engineering Research Center for Drug-Research and Development (R&D) of Neurodegenerative Diseases, Dalian Medical University, Dalian 116044, China.; Department of Biochemistry, School of Basic Medical Science, Dalian Medical University, Dalian 116044, China.
Guo Y; National-Local Joint Engineering Research Center for Drug-Research and Development (R&D) of Neurodegenerative Diseases, Dalian Medical University, Dalian 116044, China.; Department of Microecology, School of Basic Medical Science, Dalian Medical University, Dalian 116044, China.
Zhao J; National-Local Joint Engineering Research Center for Drug-Research and Development (R&D) of Neurodegenerative Diseases, Dalian Medical University, Dalian 116044, China.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Mar 17; Vol. 25 (6). Date of Electronic Publication: 2024 Mar 17.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*/drug therapy
Alzheimer Disease*/genetics
Alzheimer Disease*/metabolism
Neural Cell Adhesion Molecule L1*
Neurodegenerative Diseases*
Neuroblastoma*
Caffeic Acids*
Succinates*
Humans ; Mice ; Animals ; Amyloid Precursor Protein Secretases/genetics ; Amyloid Precursor Protein Secretases/metabolism ; Amyloid beta-Protein Precursor/metabolism ; Mice, Transgenic ; Disease Models, Animal ; Aspartic Acid Endopeptidases/metabolism ; Amyloid beta-Peptides/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Insights on the Use of Transgenic Mice Models in Alzheimer's Disease Research.
Autorzy:
Pádua MS; CIISA-Centro de Investigação Interdisciplinar em Sanidade Animal, Faculdade de Medicina Veterinária, Universidade de Lisboa, 1300-477 Lisbon, Portugal.; Laboratório Associado para Ciência Animal e Veterinária (AL4AnimalS), Faculdade de Medicina Veterinária, Universidade de Lisboa, 1300-477 Lisbon, Portugal.
Guil-Guerrero JL; Departamento de Tecnología de Alimentos, Universidad de Almería, 04120 Almería, Spain.
Prates JAM; CIISA-Centro de Investigação Interdisciplinar em Sanidade Animal, Faculdade de Medicina Veterinária, Universidade de Lisboa, 1300-477 Lisbon, Portugal.; Laboratório Associado para Ciência Animal e Veterinária (AL4AnimalS), Faculdade de Medicina Veterinária, Universidade de Lisboa, 1300-477 Lisbon, Portugal.
Lopes PA; CIISA-Centro de Investigação Interdisciplinar em Sanidade Animal, Faculdade de Medicina Veterinária, Universidade de Lisboa, 1300-477 Lisbon, Portugal.; Laboratório Associado para Ciência Animal e Veterinária (AL4AnimalS), Faculdade de Medicina Veterinária, Universidade de Lisboa, 1300-477 Lisbon, Portugal.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Feb 28; Vol. 25 (5). Date of Electronic Publication: 2024 Feb 28.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Alzheimer Disease*/metabolism
Mice ; Animals ; Humans ; Mice, Transgenic ; Disease Models, Animal ; tau Proteins/metabolism ; Amyloid beta-Protein Precursor/metabolism ; Amyloid beta-Peptides/metabolism ; Presenilin-1/genetics ; Plaque, Amyloid/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The Association of ADAMTS7 Gene Polymorphisms with the Risk of Coronary Artery Disease Occurrence and Cardiovascular Survival in the Polish Population: A Case-Control and a Prospective Cohort Study.
Autorzy:
Iwanicka J; Department of Biochemistry and Medical Genetics, School of Health Sciences in Katowice, Medical University of Silesia, Medykow Street 18, 40-752 Katowice, Poland.
Balcerzyk-Matić A; Department of Biochemistry and Medical Genetics, School of Health Sciences in Katowice, Medical University of Silesia, Medykow Street 18, 40-752 Katowice, Poland.
Iwanicki T; Department of Biochemistry and Medical Genetics, School of Health Sciences in Katowice, Medical University of Silesia, Medykow Street 18, 40-752 Katowice, Poland.
Mizia-Stec K; First Department of Cardiology, School of Medicine in Katowice, Medical University of Silesia, 47 Ziołowa St., 40-635 Katowice, Poland.
Bańka P; First Department of Cardiology, School of Medicine in Katowice, Medical University of Silesia, 47 Ziołowa St., 40-635 Katowice, Poland.
Filipecki A; First Department of Cardiology, School of Medicine in Katowice, Medical University of Silesia, 47 Ziołowa St., 40-635 Katowice, Poland.
Gawron K; Department of Molecular Biology and Genetics, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Medykow 18, 40-752 Katowice, Poland.
Jarosz A; Department of Biochemistry and Medical Genetics, School of Health Sciences in Katowice, Medical University of Silesia, Medykow Street 18, 40-752 Katowice, Poland.
Nowak T; Department of Biochemistry and Medical Genetics, School of Health Sciences in Katowice, Medical University of Silesia, Medykow Street 18, 40-752 Katowice, Poland.
Krauze J; 1st Department of Cardiac Surgery/2nd Department of Cardiology, American Heart of Poland, S. A. Armii Krajowej 101, 43-316 Bielsko-Biala, Poland.
Niemiec P; Department of Biochemistry and Medical Genetics, School of Health Sciences in Katowice, Medical University of Silesia, Medykow Street 18, 40-752 Katowice, Poland.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Feb 14; Vol. 25 (4). Date of Electronic Publication: 2024 Feb 14.
Typ publikacji:
Journal Article
MeSH Terms:
ADAMTS7 Protein*/genetics
Coronary Artery Disease*/epidemiology
Coronary Artery Disease*/genetics
Humans ; Case-Control Studies ; Gene Frequency ; Genetic Predisposition to Disease ; Genotype ; Poland/epidemiology ; Polymorphism, Single Nucleotide ; Prospective Studies ; Risk Factors
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Changes in HLA-B27 Transgenic Rat Fecal Microbiota Following Tofacitinib Treatment and Ileocecal Resection Surgery: Implications for Crohn's Disease Management.
Autorzy:
Blondeaux A; U1286-INFINITE-Institute for Translational Research in Inflammation, CHU Lille, Inserm, Univ. Lille, F-59000 Lille, France.; Department of Hepato-Gastroenterology, Lille University Hospital, 59037 Lille, France.
Valibouze C; U1286-INFINITE-Institute for Translational Research in Inflammation, CHU Lille, Inserm, Univ. Lille, F-59000 Lille, France.; Department of Hepato-Gastroenterology, Lille University Hospital, 59037 Lille, France.
Speca S; U1286-INFINITE-Institute for Translational Research in Inflammation, CHU Lille, Inserm, Univ. Lille, F-59000 Lille, France.
Rousseaux C; Intestinal Biotech Development, 1 Avenue Oscar Lambret, 59045 Lille, France.
Dubuquoy C; Intestinal Biotech Development, 1 Avenue Oscar Lambret, 59045 Lille, France.
Blanquart H; GenoScreen, 1 Rue du Pr Calmette, 59000 Lille, France.
Zerbib P; U1286-INFINITE-Institute for Translational Research in Inflammation, CHU Lille, Inserm, Univ. Lille, F-59000 Lille, France.; Department of Hepato-Gastroenterology, Lille University Hospital, 59037 Lille, France.
Desreumaux P; U1286-INFINITE-Institute for Translational Research in Inflammation, CHU Lille, Inserm, Univ. Lille, F-59000 Lille, France.; Department of Hepato-Gastroenterology, Lille University Hospital, 59037 Lille, France.
Foligné B; U1286-INFINITE-Institute for Translational Research in Inflammation, CHU Lille, Inserm, Univ. Lille, F-59000 Lille, France.
Titécat M; U1286-INFINITE-Institute for Translational Research in Inflammation, CHU Lille, Inserm, Univ. Lille, F-59000 Lille, France.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Feb 10; Vol. 25 (4). Date of Electronic Publication: 2024 Feb 10.
Typ publikacji:
Journal Article
MeSH Terms:
Crohn Disease*/drug therapy
Crohn Disease*/surgery
Crohn Disease*/complications
Inflammatory Bowel Diseases*/drug therapy
Inflammatory Bowel Diseases*/complications
Microbiota*
Piperidines*
Pyrimidines*
Rats ; Animals ; Rats, Transgenic ; HLA-B27 Antigen ; Disease Management
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
A Novel Drosophila Model of Alzheimer's Disease to Study Aβ Proteotoxicity in the Digestive Tract.
Autorzy:
Elovsson G; Department of Physics, Chemistry, and Biology, Linköping University, 581 83 Linköping, Sweden.
Klingstedt T; Department of Physics, Chemistry, and Biology, Linköping University, 581 83 Linköping, Sweden.
Brown M; Department of Physics, Chemistry, and Biology, Linköping University, 581 83 Linköping, Sweden.
Nilsson KPR; Department of Physics, Chemistry, and Biology, Linköping University, 581 83 Linköping, Sweden.
Brorsson AC; Department of Physics, Chemistry, and Biology, Linköping University, 581 83 Linköping, Sweden.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Feb 09; Vol. 25 (4). Date of Electronic Publication: 2024 Feb 09.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*/genetics
Alzheimer Disease*/metabolism
Animals ; Drosophila/metabolism ; Drosophila melanogaster/metabolism ; Amyloid beta-Peptides/genetics ; Gastrointestinal Tract/metabolism ; Disease Models, Animal
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Microglial Transforming Growth Factor-β Signaling in Alzheimer's Disease.
Autorzy:
Vidovic N; Anatomy and Cell Biology, Medical School OWL, Bielefeld University, 33615 Bielefeld, Germany.
Spittau B; Anatomy and Cell Biology, Medical School OWL, Bielefeld University, 33615 Bielefeld, Germany.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Mar 07; Vol. 25 (6). Date of Electronic Publication: 2024 Mar 07.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Alzheimer Disease*/metabolism
Mice ; Humans ; Animals ; Microglia/metabolism ; Transforming Growth Factor beta/metabolism ; Receptors, Immunologic/metabolism ; Amyloid beta-Peptides/metabolism ; Transforming Growth Factors/metabolism ; Disease Models, Animal
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
On the Inadequacy of the Current Transgenic Animal Models of Alzheimer's Disease: The Path Forward.
Autorzy:
Volloch V; Department of Developmental Biology, Harvard School of Dental Medicine, Boston, MA 02115, USA.
Rits-Volloch S; Division of Molecular Medicine, Children's Hospital, Boston, MA 02115, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Mar 04; Vol. 25 (5). Date of Electronic Publication: 2024 Mar 04.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*/metabolism
Mice ; Animals ; Amyloid beta-Protein Precursor/metabolism ; Mice, Transgenic ; Amyloid beta-Peptides/metabolism ; Disease Models, Animal
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Embryonic Amoxicillin Exposure Has Limited Impact on Liver Development but Increases Susceptibility to NAFLD in Zebrafish Larvae.
Autorzy:
Gao P; TaiKang Medical School (School of Basic Medical Sciences), Wuhan University, Wuhan 430071, China.
Chang C; TaiKang Medical School (School of Basic Medical Sciences), Wuhan University, Wuhan 430071, China.
Liang J; TaiKang Medical School (School of Basic Medical Sciences), Wuhan University, Wuhan 430071, China.
Du F; TaiKang Medical School (School of Basic Medical Sciences), Wuhan University, Wuhan 430071, China.
Zhang R; TaiKang Medical School (School of Basic Medical Sciences), Wuhan University, Wuhan 430071, China.; Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan 430071, China.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Feb 27; Vol. 25 (5). Date of Electronic Publication: 2024 Feb 27.
Typ publikacji:
Journal Article
MeSH Terms:
Non-alcoholic Fatty Liver Disease*/metabolism
Animals ; Zebrafish ; Amoxicillin/metabolism ; Larva ; Disease Susceptibility/metabolism ; Liver/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Deletion of Gadd45a Expression in Mice Leads to Cognitive and Synaptic Impairment Associated with Alzheimer's Disease Hallmarks.
Autorzy:
Griñán-Ferré C; Department of Pharmacology, Toxicology and Therapeutic Chemistry, University of Barcelona, Avda. Joan XXIII 27, 08028 Barcelona, Spain.; Institute of Neurosciences of the University of Barcelona, University of Barcelona, 08035 Barcelona, Spain.; Spanish Biomedical Research Center in Neurodegenerative Diseases (CIBERNED)-National Institute of Health Carlos III, 28029 Madrid, Spain.
Jarne-Ferrer J; Department of Pharmacology, Toxicology and Therapeutic Chemistry, University of Barcelona, Avda. Joan XXIII 27, 08028 Barcelona, Spain.; Institute of Neurosciences of the University of Barcelona, University of Barcelona, 08035 Barcelona, Spain.
Bellver-Sanchis A; Department of Pharmacology, Toxicology and Therapeutic Chemistry, University of Barcelona, Avda. Joan XXIII 27, 08028 Barcelona, Spain.; Institute of Neurosciences of the University of Barcelona, University of Barcelona, 08035 Barcelona, Spain.
Ribalta-Vilella M; Department of Pharmacology, Toxicology and Therapeutic Chemistry, University of Barcelona, Avda. Joan XXIII 27, 08028 Barcelona, Spain.; Institute of Neurosciences of the University of Barcelona, University of Barcelona, 08035 Barcelona, Spain.
Barroso E; Department of Pharmacology, Toxicology and Therapeutic Chemistry, University of Barcelona, Avda. Joan XXIII 27, 08028 Barcelona, Spain.; Institute of Biomedicine of the University of Barcelona (IBUB), University of Barcelona, 08028 Barcelona, Spain.; Spanish Biomedical Research Center in Diabetes and Associated Metabolic Diseases (CIBERDEM)-National Institute of Health Carlos III, 28029 Madrid, Spain.; Pediatric Research Institute-Hospital Sant Joan de Déu, Esplugues de Llobregat, 08950 Barcelona, Spain.
Salvador JM; Department of Immunology and Oncology, National Center for Biotechnology/CSIC, 28049 Madrid, Spain.
Jurado-Aguilar J; Department of Pharmacology, Toxicology and Therapeutic Chemistry, University of Barcelona, Avda. Joan XXIII 27, 08028 Barcelona, Spain.; Institute of Biomedicine of the University of Barcelona (IBUB), University of Barcelona, 08028 Barcelona, Spain.; Spanish Biomedical Research Center in Diabetes and Associated Metabolic Diseases (CIBERDEM)-National Institute of Health Carlos III, 28029 Madrid, Spain.; Pediatric Research Institute-Hospital Sant Joan de Déu, Esplugues de Llobregat, 08950 Barcelona, Spain.
Palomer X; Department of Pharmacology, Toxicology and Therapeutic Chemistry, University of Barcelona, Avda. Joan XXIII 27, 08028 Barcelona, Spain.; Institute of Biomedicine of the University of Barcelona (IBUB), University of Barcelona, 08028 Barcelona, Spain.; Spanish Biomedical Research Center in Diabetes and Associated Metabolic Diseases (CIBERDEM)-National Institute of Health Carlos III, 28029 Madrid, Spain.; Pediatric Research Institute-Hospital Sant Joan de Déu, Esplugues de Llobregat, 08950 Barcelona, Spain.
Vázquez-Carrera M; Department of Pharmacology, Toxicology and Therapeutic Chemistry, University of Barcelona, Avda. Joan XXIII 27, 08028 Barcelona, Spain.; Institute of Biomedicine of the University of Barcelona (IBUB), University of Barcelona, 08028 Barcelona, Spain.; Spanish Biomedical Research Center in Diabetes and Associated Metabolic Diseases (CIBERDEM)-National Institute of Health Carlos III, 28029 Madrid, Spain.; Pediatric Research Institute-Hospital Sant Joan de Déu, Esplugues de Llobregat, 08950 Barcelona, Spain.
Pallàs M; Department of Pharmacology, Toxicology and Therapeutic Chemistry, University of Barcelona, Avda. Joan XXIII 27, 08028 Barcelona, Spain.; Institute of Neurosciences of the University of Barcelona, University of Barcelona, 08035 Barcelona, Spain.; Spanish Biomedical Research Center in Neurodegenerative Diseases (CIBERNED)-National Institute of Health Carlos III, 28029 Madrid, Spain.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Feb 23; Vol. 25 (5). Date of Electronic Publication: 2024 Feb 23.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*/metabolism
Cognitive Dysfunction*/metabolism
Mice ; Animals ; Mice, Transgenic ; tau Proteins/metabolism ; Hippocampus/metabolism ; Cognition ; Disease Models, Animal
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Autosomal Dominant Alzheimer's Disease Mutations in Human Microglia Are Not Sufficient to Trigger Amyloid Pathology in WT Mice but Might Affect Pathology in 5XFAD Mice.
Autorzy:
Romero-Molina C; Ronald M. Loeb Center for Alzheimer's Disease, Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY 10029, USA.
Neuner SM; Ronald M. Loeb Center for Alzheimer's Disease, Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY 10029, USA.
Ryszawiec M; Ronald M. Loeb Center for Alzheimer's Disease, Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY 10029, USA.
Pébay A; Department of Anatomy and Physiology, Department of Surgery, Royal Melbourne Hospital, The University of Melbourne, Melbourne, VIC 3010, Australia.
Dominantly Inherited Alzheimer Network; Department of Neurology, Washington University, St. Louis, MO 63110, USA.
Marcora E; Ronald M. Loeb Center for Alzheimer's Disease, Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY 10029, USA.
Goate A; Ronald M. Loeb Center for Alzheimer's Disease, Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY 10029, USA.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Feb 22; Vol. 25 (5). Date of Electronic Publication: 2024 Feb 22.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*
Humans ; Animals ; Mice ; Microglia ; Amyloidogenic Proteins ; Amyloid beta-Protein Precursor ; Mutation ; Plaque, Amyloid ; Presenilin-1 ; Amyloid beta-Peptides ; Mice, Transgenic ; Disease Models, Animal
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Factor H's Control of Complement Activation Emerges as a Significant and Promising Therapeutic Target for Alzheimer's Disease Treatment.
Autorzy:
Hasantari I; INSERM (Institut National de la Santé et de la Recherche Médicale), Biologie des Maladies Cardiovasculaires, U1034, University Bordeaux, F-33600 Pessac, France.
Nicolas N; INSERM (Institut National de la Santé et de la Recherche Médicale), Biologie des Maladies Cardiovasculaires, U1034, University Bordeaux, F-33600 Pessac, France.
Alzieu P; INSERM (Institut National de la Santé et de la Recherche Médicale), Biologie des Maladies Cardiovasculaires, U1034, University Bordeaux, F-33600 Pessac, France.
Leval L; INSERM (Institut National de la Santé et de la Recherche Médicale), Biologie des Maladies Cardiovasculaires, U1034, University Bordeaux, F-33600 Pessac, France.
Shalabi A; Medizinische Hochschule Hannover, Abt. Infektiologie, 30625 Hannover, Germany.
Grolleau S; INSERM (Institut National de la Santé et de la Recherche Médicale), Biologie des Maladies Cardiovasculaires, U1034, University Bordeaux, F-33600 Pessac, France.
Dinet V; INSERM (Institut National de la Santé et de la Recherche Médicale), Biologie des Maladies Cardiovasculaires, U1034, University Bordeaux, F-33600 Pessac, France.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Feb 14; Vol. 25 (4). Date of Electronic Publication: 2024 Feb 14.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*/metabolism
Mice ; Animals ; Amyloid beta-Peptides/metabolism ; Amyloid beta-Protein Precursor/metabolism ; Complement Factor H ; Mice, Transgenic ; Complement Activation ; Disease Models, Animal
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Deregulated Transcriptome as a Platform for Adrenal Huntington's Disease-Related Pathology.
Autorzy:
Olechnowicz A; Department of Histology and Embryology, Poznan University of Medical Sciences, 61-701 Poznan, Poland.; Doctoral School, Poznan University of Medical Sciences, 60-812 Poznan, Poland.
Blatkiewicz M; Department of Histology and Embryology, Poznan University of Medical Sciences, 61-701 Poznan, Poland.
Jopek K; Department of Histology and Embryology, Poznan University of Medical Sciences, 61-701 Poznan, Poland.
Isalan M; Department of Life Sciences, Imperial College London, Exhibition Road, London SW7 2AZ, UK.; Imperial College Centre for Synthetic Biology, Imperial College London, London SW7 2AZ, UK.
Mielcarek M; Department of Life Sciences, Imperial College London, Exhibition Road, London SW7 2AZ, UK.; Imperial College Centre for Synthetic Biology, Imperial College London, London SW7 2AZ, UK.
Rucinski M; Department of Histology and Embryology, Poznan University of Medical Sciences, 61-701 Poznan, Poland.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Feb 11; Vol. 25 (4). Date of Electronic Publication: 2024 Feb 11.
Typ publikacji:
Journal Article
MeSH Terms:
Huntington Disease*/metabolism
Mice ; Animals ; Mice, Transgenic ; Transcriptome ; Disease Models, Animal ; Gene Expression Regulation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Modeling Spinal Muscular Atrophy in Zebrafish: Current Advances and Future Perspectives.
Autorzy:
Gonzalez D; Millennium Institute Center for Genome Regulation, Facultad de Ciencias, Universidad de Chile, Santiago 7800003, RM, Chile.; Departamento de Ciencias Químicas y Biológicas, Facultad de Ciencias de la Salud, Universidad Bernardo O'Higgins, Santiago 8370854, RM, Chile.
Vásquez-Doorman C; Millennium Institute Center for Genome Regulation, Facultad de Ciencias, Universidad de Chile, Santiago 7800003, RM, Chile.; Departamento de Ciencias Químicas y Biológicas, Facultad de Ciencias de la Salud, Universidad Bernardo O'Higgins, Santiago 8370854, RM, Chile.
Luna A; Departamento de Ciencias Químicas y Biológicas, Facultad de Ciencias de la Salud, Universidad Bernardo O'Higgins, Santiago 8370854, RM, Chile.
Allende ML; Millennium Institute Center for Genome Regulation, Facultad de Ciencias, Universidad de Chile, Santiago 7800003, RM, Chile.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Feb 06; Vol. 25 (4). Date of Electronic Publication: 2024 Feb 06.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Neurodegenerative Diseases*
Muscular Atrophy, Spinal*/therapy
Motor Neuron Disease*
Animals ; Humans ; Zebrafish/genetics ; Motor Neurons ; Survival of Motor Neuron 1 Protein ; Disease Models, Animal
Czasopismo naukowe
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Tytuł:
Prognostic Value of Gut Microbiome for Conversion from Mild Cognitive Impairment to Alzheimer's Disease Dementia within 4 Years: Results from the AlzBiom Study.
Autorzy:
Laske C; Section for Dementia Research, Hertie Institute for Clinical Brain Research, Department of Psychiatry and Psychotherapy, University of Tübingen, 72076 Tübingen, Germany.; Department of Psychiatry and Psychotherapy, University of Tübingen, 72076 Tübingen, Germany.; German Center for Neurodegenerative Diseases (DZNE), 72076 Tübingen, Germany.
Müller S; Department of Psychiatry and Psychotherapy, University of Tübingen, 72076 Tübingen, Germany.
Munk MHJ; Department of Psychiatry and Psychotherapy, University of Tübingen, 72076 Tübingen, Germany.; German Center for Neurodegenerative Diseases (DZNE), 72076 Tübingen, Germany.; Department of Biology, Technische Universität Darmstadt, 64277 Darmstadt, Germany.
Honold I; Department of Psychiatry and Psychotherapy, University of Tübingen, 72076 Tübingen, Germany.
Willmann M; SYNLAB MVZ Leinfelden-Echterdingen GmbH, Labor Dr. Bayer, 70771 Leinfelden-Echterdingen, Germany.
Peter S; Institute of Medical Microbiology and Hygiene, University of Tübingen, 72076 Tübingen, Germany.
Schoppmeier U; Institute of Medical Microbiology and Hygiene, University of Tübingen, 72076 Tübingen, Germany.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Feb 05; Vol. 25 (3). Date of Electronic Publication: 2024 Feb 05.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*/genetics
Gastrointestinal Microbiome*/genetics
Cognitive Dysfunction*/etiology
Humans ; Longitudinal Studies ; Prognosis ; Disease Progression ; Biomarkers
Czasopismo naukowe
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Tytuł:
Formulating Treatment to Cure Alzheimer's Dementia: Approach #2.
Autorzy:
Fessel J; Department of Medicine, University of California, 2069 Filbert Street, San Francisco, CA 94123, USA.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Mar 20; Vol. 25 (6). Date of Electronic Publication: 2024 Mar 20.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Alzheimer Disease*/therapy
Cognitive Dysfunction*
Humans ; Cognition ; Brain ; Disease Progression
Czasopismo naukowe
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Tytuł:
Animals in Respiratory Research.
Autorzy:
Fröhlich E; Center for Medical Research, Medical University of Graz, 8010 Graz, Austria.; Research Center Pharmaceutical Engineering GmbH, 8010 Graz, Austria.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Mar 01; Vol. 25 (5). Date of Electronic Publication: 2024 Mar 01.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Pulmonary Disease, Chronic Obstructive*/drug therapy
Asthma*/drug therapy
Animals ; Mice ; Humans ; Zebrafish ; Lung ; Disease Models, Animal ; Mammals
Czasopismo naukowe
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Tytuł:
Proteomic Analysis of a Rat Streptozotocin Model Shows Dysregulated Biological Pathways Implicated in Alzheimer's Disease.
Autorzy:
da Silva EMG; Instituto Carlos Chagas, FIOCRUZ, Curitiba 81310-020, PR, Brazil.; Laboratory of Toxinology, Oswaldo Cruz Institute, Fiocruz, Rio de Janeiro 21040-361, RJ, Brazil.
Fischer JSG; Instituto Carlos Chagas, FIOCRUZ, Curitiba 81310-020, PR, Brazil.
Souza ILS; Laboratory of Polymorphisms and Linkage, Federal University of Paraná, Curitiba 81530-001, PR, Brazil.
Andrade ACC; Instituto Carlos Chagas, FIOCRUZ, Curitiba 81310-020, PR, Brazil.
Souza LCE; Department of Pharmacology, Federal University of Paraná, Curitiba 80050-540, PR, Brazil.
Andrade MK; Department of Pharmacology, Federal University of Paraná, Curitiba 80050-540, PR, Brazil.
Carvalho PC; Instituto Carlos Chagas, FIOCRUZ, Curitiba 81310-020, PR, Brazil.
Souza RLR; Laboratory of Polymorphisms and Linkage, Federal University of Paraná, Curitiba 81530-001, PR, Brazil.
Vital MABF; Department of Pharmacology, Federal University of Paraná, Curitiba 80050-540, PR, Brazil.
Passetti F; Instituto Carlos Chagas, FIOCRUZ, Curitiba 81310-020, PR, Brazil.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Feb 28; Vol. 25 (5). Date of Electronic Publication: 2024 Feb 28.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*/metabolism
Rats ; Male ; Animals ; Rats, Wistar ; Streptozocin ; Proteome ; Proteomics ; Disease Models, Animal ; Maze Learning
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Non-Necroptotic Roles of MLKL in Diet-Induced Obesity, Liver Pathology, and Insulin Sensitivity: Insights from a High-Fat, High-Fructose, High-Cholesterol Diet Mouse Model.
Autorzy:
Ohene-Marfo P; Department of Biochemistry and Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
Nguyen HVM; Department of Nutritional Sciences, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
Mohammed S; Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
Thadathil N; Department of Biochemistry and Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
Tran A; Department of Biochemistry and Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
Nicklas EH; Department of Biochemistry and Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
Wang D; Department of Biochemistry and Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
Selvarani R; Department of Biochemistry and Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
Farriester JW; Department of Biochemistry and Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.; Harold Hamm Diabetes Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
Varshney R; Department of Biochemistry and Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.; Harold Hamm Diabetes Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
Kinter M; Aging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA.
Richardson A; Department of Biochemistry and Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.; Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.; Oklahoma Center for Geroscience & Brain Aging, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.; Oklahoma City VA Medical Center, Oklahoma City, OK 73104, USA.
Rudolph MC; Department of Biochemistry and Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.; Harold Hamm Diabetes Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
Deepa SS; Department of Biochemistry and Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.; Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.; Aging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Feb 28; Vol. 25 (5). Date of Electronic Publication: 2024 Feb 28.
Typ publikacji:
Journal Article
MeSH Terms:
Insulin Resistance*
Non-alcoholic Fatty Liver Disease*/metabolism
Humans ; Mice ; Animals ; Fructose ; Protein Kinases/metabolism ; Obesity/metabolism ; Disease Models, Animal ; Diet, High-Fat/adverse effects ; Adipose Tissue/metabolism ; Inflammation ; Cholesterol ; Receptor-Interacting Protein Serine-Threonine Kinases/metabolism
Czasopismo naukowe
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Tytuł:
Genomic Regions and Candidate Genes Affecting Response to Heat Stress with Newcastle Virus Infection in Commercial Layer Chicks Using Chicken 600K Single Nucleotide Polymorphism Array.
Autorzy:
Wang Y; Genomics to Improve Poultry Innovation Lab, University of California, Davis, CA 95616, USA.; Department of Animal Science, University of California, Davis, CA 95616, USA.
Saelao P; Genomics to Improve Poultry Innovation Lab, University of California, Davis, CA 95616, USA.; Department of Animal Science, University of California, Davis, CA 95616, USA.; Veterinary Pest Genetics Research Unit, United States Department of Agriculture U, Kerrville, TX 78006, USA.
Chanthavixay G; Genomics to Improve Poultry Innovation Lab, University of California, Davis, CA 95616, USA.; Department of Animal Science, University of California, Davis, CA 95616, USA.
Gallardo RA; Genomics to Improve Poultry Innovation Lab, University of California, Davis, CA 95616, USA.; School of Veterinary Medicine, University of California, Davis, CA 95616, USA.
Wolc A; Department of Animal Science, Iowa State University, Ames, IA 50011, USA.; Hy-Line International, Dallas Center, IA 50063, USA.
Fulton JE; Hy-Line International, Dallas Center, IA 50063, USA.
Dekkers JM; Department of Animal Science, Iowa State University, Ames, IA 50011, USA.
Lamont SJ; Department of Animal Science, Iowa State University, Ames, IA 50011, USA.
Kelly TR; Genomics to Improve Poultry Innovation Lab, University of California, Davis, CA 95616, USA.; School of Veterinary Medicine, University of California, Davis, CA 95616, USA.
Zhou H; Genomics to Improve Poultry Innovation Lab, University of California, Davis, CA 95616, USA.; Department of Animal Science, University of California, Davis, CA 95616, USA.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Feb 24; Vol. 25 (5). Date of Electronic Publication: 2024 Feb 24.
Typ publikacji:
Journal Article
MeSH Terms:
Chickens*/genetics
Newcastle Disease*/genetics
Animals ; Polymorphism, Single Nucleotide ; Genome-Wide Association Study ; Carbon Dioxide ; Heat-Shock Response ; Genomics ; Newcastle disease virus/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Wyświetlanie 1-20 z 46625

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