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Tytuł :
Epigenetic manipulation of filamentous fungi for biotechnological applications: a systematic review.
Autorzy :
Poças-Fonseca MJ; Department of Genetics and Morphology, University of Brasilia, 70.910-900, Brasília, DF, Brazil. .
Cabral CG; Department of Genetics and Morphology, University of Brasilia, 70.910-900, Brasília, DF, Brazil.; Graduation Program in Nanoscience and Nanobiotechnology, University of Brasilia, Brasília, DF, Brazil.
Manfrão-Netto JHC; Department of Genetics and Morphology, University of Brasilia, 70.910-900, Brasília, DF, Brazil.; Graduation Program in Molecular Biology, University of Brasilia, Brasília, DF, Brazil.
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Źródło :
Biotechnology letters [Biotechnol Lett] 2020 Jun; Vol. 42 (6), pp. 885-904. Date of Electronic Publication: 2020 Apr 03.
Typ publikacji :
Journal Article; Systematic Review
MeSH Terms :
Epigenesis, Genetic*
Fungi*
Gene Expression Regulation, Fungal*
Biotechnology ; Candida albicans ; Gene Deletion ; Histone Deacetylase Inhibitors
Czasopismo naukowe
Tytuł :
JAK Inhibitors Suppress Innate Epigenetic Reprogramming: a Promise for Patients with Sjögren's Syndrome.
Autorzy :
Charras A; University of Brest, UMR1227, B Lymphocytes B and Autoimmunity, Brest, France.
Arvaniti P; Laboratory of Immunology and Immunotherapy, CHU de Brest, France.; Institute of Internal Medicine and Hepatology, Larissa, Greece.; Department of Medicine and Research Laboratory of Internal Medicine, University Hospital of Larissa, Larissa, Greece.
Le Dantec C; University of Brest, UMR1227, B Lymphocytes B and Autoimmunity, Brest, France.
Arleevskaya MI; Central Research Laboratory, Kazan Federal University, Kazan, Russia.
Zachou K; Institute of Internal Medicine and Hepatology, Larissa, Greece.; Department of Medicine and Research Laboratory of Internal Medicine, University Hospital of Larissa, Larissa, Greece.
Dalekos GN; Institute of Internal Medicine and Hepatology, Larissa, Greece.; Department of Medicine and Research Laboratory of Internal Medicine, University Hospital of Larissa, Larissa, Greece.
Bordon A; University of Brest, UMR1227, B Lymphocytes B and Autoimmunity, Brest, France.
Renaudineau Y; University of Brest, UMR1227, B Lymphocytes B and Autoimmunity, Brest, France. .; Laboratory of Immunology and Immunotherapy, CHU de Brest, France. .; Central Research Laboratory, Kazan Federal University, Kazan, Russia. .
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Źródło :
Clinical reviews in allergy & immunology [Clin Rev Allergy Immunol] 2020 Apr; Vol. 58 (2), pp. 182-193.
Typ publikacji :
Journal Article
MeSH Terms :
Cellular Reprogramming/*drug effects
Cellular Reprogramming/*genetics
Epigenesis, Genetic/*drug effects
Immunity, Innate/*drug effects
Janus Kinase Inhibitors/*therapeutic use
Sjogren's Syndrome/*drug therapy
Sjogren's Syndrome/*etiology
DNA Methylation/drug effects ; Gene Expression Profiling ; Gene Expression Regulation, Enzymologic ; Humans ; Hydrogen Peroxide/metabolism ; Janus Kinase Inhibitors/pharmacology ; Janus Kinases/metabolism ; Models, Biological ; Phosphorylation ; Reactive Oxygen Species/metabolism ; STAT1 Transcription Factor/metabolism ; STAT3 Transcription Factor/metabolism ; Signal Transduction/drug effects ; Sjogren's Syndrome/metabolism
Czasopismo naukowe
Tytuł :
DNA Methylation in Neurodegenerative and Cerebrovascular Disorders.
Autorzy :
Martínez-Iglesias O; Euroespes Biomedical Research Center, International Center of Neuroscience and Genomic Medicine, 15165 Corunna, Spain.
Carrera I; Euroespes Biomedical Research Center, International Center of Neuroscience and Genomic Medicine, 15165 Corunna, Spain.
Carril JC; Euroespes Biomedical Research Center, International Center of Neuroscience and Genomic Medicine, 15165 Corunna, Spain.
Fernández-Novoa L; Euroespes Biomedical Research Center, International Center of Neuroscience and Genomic Medicine, 15165 Corunna, Spain.
Cacabelos N; Euroespes Biomedical Research Center, International Center of Neuroscience and Genomic Medicine, 15165 Corunna, Spain.
Cacabelos R; Euroespes Biomedical Research Center, International Center of Neuroscience and Genomic Medicine, 15165 Corunna, Spain.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Mar 23; Vol. 21 (6). Date of Electronic Publication: 2020 Mar 23.
Typ publikacji :
Journal Article
MeSH Terms :
DNA Methylation*
Epigenesis, Genetic*
Cerebrovascular Disorders/*etiology
Neurocognitive Disorders/*etiology
Animals ; Biomarkers ; Cerebrovascular Disorders/diagnosis ; Cerebrovascular Disorders/metabolism ; Disease Models, Animal ; Disease Susceptibility ; Gene Expression Profiling ; Gene Expression Regulation ; Mice ; Mice, Transgenic ; Neurocognitive Disorders/diagnosis ; Neurocognitive Disorders/metabolism
Czasopismo naukowe
Tytuł :
The frequency of CpG and non-CpG methylation of Notch3 gene promoter determines its expression levels in breast cancer cells.
Autorzy :
Xiao W; The Central Laboratory of Cancer Hospital of Shantou University Medical College, 7 Raoping Road, Shantou, 515031, China; Present Address: Health Science Center of Shenzhen University Medical College, Shenzhen, 518055, China.
Liu X; The Central Laboratory of Cancer Hospital of Shantou University Medical College, 7 Raoping Road, Shantou, 515031, China.
Niu X; The Central Laboratory of Cancer Hospital of Shantou University Medical College, 7 Raoping Road, Shantou, 515031, China.
Li C; The Central Laboratory of Cancer Hospital of Shantou University Medical College, 7 Raoping Road, Shantou, 515031, China.
Guo Y; The Central Laboratory of Cancer Hospital of Shantou University Medical College, 7 Raoping Road, Shantou, 515031, China.
Tan J; The Central Laboratory of Cancer Hospital of Shantou University Medical College, 7 Raoping Road, Shantou, 515031, China.
Xiong W; The Central Laboratory of Cancer Hospital of Shantou University Medical College, 7 Raoping Road, Shantou, 515031, China.
Fan L; The Central Laboratory of Cancer Hospital of Shantou University Medical College, 7 Raoping Road, Shantou, 515031, China.
Li Y; The Central Laboratory of Cancer Hospital of Shantou University Medical College, 7 Raoping Road, Shantou, 515031, China. Electronic address: .
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Źródło :
Experimental cell research [Exp Cell Res] 2020 Jan 15; Vol. 386 (2), pp. 111743. Date of Electronic Publication: 2019 Nov 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Epigenesis, Genetic*
Gene Expression Regulation, Neoplastic*
Promoter Regions, Genetic*
Receptor, Notch3/*genetics
Antimetabolites, Antineoplastic/pharmacology ; Base Sequence ; Cell Line, Tumor ; CpG Islands ; DNA (Cytosine-5-)-Methyltransferase 1/genetics ; DNA (Cytosine-5-)-Methyltransferase 1/metabolism ; DNA (Cytosine-5-)-Methyltransferases/genetics ; DNA (Cytosine-5-)-Methyltransferases/metabolism ; DNA Methylation/drug effects ; Decitabine/pharmacology ; Enhancer of Zeste Homolog 2 Protein/genetics ; Enhancer of Zeste Homolog 2 Protein/metabolism ; Female ; Genes, Reporter ; Humans ; Luciferases/genetics ; Luciferases/metabolism ; MCF-7 Cells ; Methyl-CpG-Binding Protein 2/genetics ; Methyl-CpG-Binding Protein 2/metabolism ; Receptor, Notch3/deficiency ; Signal Transduction ; Triple Negative Breast Neoplasms/genetics ; Triple Negative Breast Neoplasms/metabolism ; Triple Negative Breast Neoplasms/pathology
Czasopismo naukowe
Tytuł :
Role of protein-protein interactions in allosteric drug design for DNA methyltransferases.
Autorzy :
Liang Z; Center for Systems Biology, School of Biology and Basic Medical Sciences, Soochow University, Suzhou, Jiangsu, People's Republic of China.
Zhu Y; Center for Systems Biology, School of Biology and Basic Medical Sciences, Soochow University, Suzhou, Jiangsu, People's Republic of China.
Liu X; Center for Systems Biology, School of Biology and Basic Medical Sciences, Soochow University, Suzhou, Jiangsu, People's Republic of China.
Hu G; Center for Systems Biology, School of Biology and Basic Medical Sciences, Soochow University, Suzhou, Jiangsu, People's Republic of China.
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Źródło :
Advances in protein chemistry and structural biology [Adv Protein Chem Struct Biol] 2020; Vol. 121, pp. 49-84. Date of Electronic Publication: 2020 Jan 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Drug Design*
Epigenesis, Genetic*
DNA (Cytosine-5-)-Methyltransferase 1/*antagonists & inhibitors
DNA (Cytosine-5-)-Methyltransferases/*antagonists & inhibitors
Enzyme Inhibitors/*chemistry
Allosteric Regulation/drug effects ; Allosteric Site ; Amino Acid Sequence ; DNA/metabolism ; DNA (Cytosine-5-)-Methyltransferase 1/genetics ; DNA (Cytosine-5-)-Methyltransferase 1/metabolism ; DNA (Cytosine-5-)-Methyltransferases/genetics ; DNA (Cytosine-5-)-Methyltransferases/metabolism ; DNA Methylation/drug effects ; Drug Discovery ; Enzyme Inhibitors/pharmacology ; Evolution, Molecular ; Humans ; Molecular Dynamics Simulation ; Protein Binding ; Protein Interaction Mapping
Czasopismo naukowe
Tytuł :
Genome-wide analysis of DNA methylation in endometriosis using Illumina Human Methylation 450 K BeadChips.
Autorzy :
Wang L; Department of Gynecology, Fourth Hospital, Hebei Medical University, Shijiazhuang, Hebei, China.
Zhao J; Department of Gynecology, Fourth Hospital, Hebei Medical University, Shijiazhuang, Hebei, China.
Li Y; Department of Molecular Biology, Hebei Medical University, Shijiazhuang, Hebei, China.
Wang Z; Department of Gynecology, Fourth Hospital, Hebei Medical University, Shijiazhuang, Hebei, China.
Kang S; Department of Gynecology, Fourth Hospital, Hebei Medical University, Shijiazhuang, Hebei, China.
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Źródło :
Molecular reproduction and development [Mol Reprod Dev] 2019 May; Vol. 86 (5), pp. 491-501. Date of Electronic Publication: 2019 Feb 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Endometriosis*/genetics
Endometriosis*/pathology
DNA Methylation/*genetics
Epigenesis, Genetic/*genetics
Oligonucleotide Array Sequence Analysis/*methods
Adult ; DNA (Cytosine-5-)-Methyltransferases/analysis ; DNA (Cytosine-5-)-Methyltransferases/genetics ; DNA-Binding Proteins/analysis ; DNA-Binding Proteins/genetics ; Female ; Humans
Czasopismo naukowe
Tytuł :
Sarcosine is a prostate epigenetic modifier that elicits aberrant methylation patterns through the SAMe-Dnmts axis.
Autorzy :
Strmiska V; Department of Chemistry and Biochemistry, Mendel University in Brno, Czech Republic.
Michalek P; Department of Chemistry and Biochemistry, Mendel University in Brno, Czech Republic.; Central European Institute of Technology, Brno University of Technology, Czech Republic.
Lackova Z; Department of Chemistry and Biochemistry, Mendel University in Brno, Czech Republic.; Central European Institute of Technology, Brno University of Technology, Czech Republic.
Guran R; Department of Chemistry and Biochemistry, Mendel University in Brno, Czech Republic.; Central European Institute of Technology, Brno University of Technology, Czech Republic.
Krizkova S; Department of Chemistry and Biochemistry, Mendel University in Brno, Czech Republic.; Central European Institute of Technology, Brno University of Technology, Czech Republic.
Vanickova L; Department of Chemistry and Biochemistry, Mendel University in Brno, Czech Republic.; Central European Institute of Technology, Brno University of Technology, Czech Republic.
Zitka O; Department of Chemistry and Biochemistry, Mendel University in Brno, Czech Republic.; Central European Institute of Technology, Brno University of Technology, Czech Republic.
Stiborova M; Department of Biochemistry, Faculty of Science, Charles University, Prague 2, Czech Republic.
Eckschlager T; Department of Paediatric Haematology and Oncology, 2nd Faculty of Medicine, Charles University, University Hospital Motol, Prague 5, Czech Republic.
Klejdus B; Department of Chemistry and Biochemistry, Mendel University in Brno, Czech Republic.; Central European Institute of Technology, Mendel University in Brno, Czech Republic.
Pacik D; Department of Urology, University Hospital Brno, Brno, Czech Republic.; Faculty of Medicine, Masaryk University, Brno, Czech Republic.
Tvrdikova E; Department of Pathology, University Hospital Brno, Czech Republic.
Keil C; Department of Food Chemistry and Toxicology, Technical University of Berlin, Germany.
Haase H; Department of Food Chemistry and Toxicology, Technical University of Berlin, Germany.
Adam V; Department of Chemistry and Biochemistry, Mendel University in Brno, Czech Republic.; Central European Institute of Technology, Brno University of Technology, Czech Republic.
Heger Z; Department of Chemistry and Biochemistry, Mendel University in Brno, Czech Republic.; Central European Institute of Technology, Brno University of Technology, Czech Republic.
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Źródło :
Molecular oncology [Mol Oncol] 2019 May; Vol. 13 (5), pp. 1002-1017. Date of Electronic Publication: 2019 Mar 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
CpG Islands*
Epigenesis, Genetic/*drug effects
Gene Expression Regulation, Neoplastic/*drug effects
Prostate/*metabolism
Prostatic Neoplasms/*metabolism
Sarcosine/*pharmacology
Up-Regulation/*drug effects
Cell Line ; Humans ; Male ; Prostate/pathology ; Prostatic Neoplasms/pathology
Czasopismo naukowe
Tytuł :
DNA Methylation Reprogramming during Mammalian Development.
Autorzy :
Zeng Y; Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, 1808 Park Road 1C, Smithville, TX 78957, USA. .; Center for Cancer Epigenetics, The University of Texas MD Anderson Cancer Center, Smithville, TX 78957, USA. .; Program in Genetics and Epigenetics, The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX 77030, USA. .
Chen T; Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, 1808 Park Road 1C, Smithville, TX 78957, USA. .; Center for Cancer Epigenetics, The University of Texas MD Anderson Cancer Center, Smithville, TX 78957, USA. .; Program in Genetics and Epigenetics, The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX 77030, USA. .
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Źródło :
Genes [Genes (Basel)] 2019 Mar 29; Vol. 10 (4). Date of Electronic Publication: 2019 Mar 29.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Epigenesis, Genetic*
DNA Methylation/*genetics
Embryonic Development/*genetics
Animals ; Embryo, Mammalian ; Gene Expression Regulation, Developmental ; Genome/genetics ; Genomic Imprinting ; Germ Cells/growth & development ; Germ Cells/metabolism ; Humans ; Mammals/genetics ; Mammals/growth & development
Czasopismo naukowe
Tytuł :
Aflatoxin B 1 induced multiple epigenetic modulators in human epithelial cell lines.
Autorzy :
Soni P; Department of Biochemistry and Molecular Biology, School of Biological Sciences, Central University of Kerala, Kasargod 671314, Kerala, India.
Ghufran MS; Department of Biochemistry and Molecular Biology, School of Biological Sciences, Central University of Kerala, Kasargod 671314, Kerala, India.
Kanade SR; Department of Biochemistry and Molecular Biology, School of Biological Sciences, Central University of Kerala, Kasargod 671314, Kerala, India. Electronic address: .
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Źródło :
Toxicon : official journal of the International Society on Toxinology [Toxicon] 2018 Sep 01; Vol. 151, pp. 119-128. Date of Electronic Publication: 2018 Jul 11.
Typ publikacji :
Journal Article
MeSH Terms :
Aflatoxin B1/*toxicity
Epigenesis, Genetic/*drug effects
Epithelial Cells/*drug effects
Cell Line ; Cell Proliferation/drug effects ; DNA Modification Methylases/genetics ; DNA Modification Methylases/metabolism ; Gene Expression Regulation, Enzymologic/drug effects ; Histone Acetyltransferases/genetics ; Histone Acetyltransferases/metabolism ; Histone Deacetylases/genetics ; Histone Deacetylases/metabolism ; Histones/metabolism ; Humans ; Keratinocytes/drug effects ; Polycomb-Group Proteins/genetics ; Polycomb-Group Proteins/metabolism
Czasopismo naukowe
Tytuł :
DNA methylation and potential multigenerational epigenetic effects linked to uranium chronic low-dose exposure in gonads of males and females rats.
Autorzy :
Elmhiri G; Institut de Radioprotection et de SÛreté Nucléaire (IRSN), PRP-HOM, SRBE, LRTOX, Fontenay-aux Roses, France; Institut de Radioprotection et de SÛreté Nucléaire (IRSN), PRP-HOM, Fontenay-aux Roses, France.
Gloaguen C; Institut de Radioprotection et de SÛreté Nucléaire (IRSN), PRP-HOM, SRBE, LRTOX, Fontenay-aux Roses, France; Institut de Radioprotection et de SÛreté Nucléaire (IRSN), PRP-HOM, Fontenay-aux Roses, France.
Grison S; Institut de Radioprotection et de SÛreté Nucléaire (IRSN), PRP-HOM, SRBE, LRTOX, Fontenay-aux Roses, France; Institut de Radioprotection et de SÛreté Nucléaire (IRSN), PRP-HOM, Fontenay-aux Roses, France.
Kereselidze D; Institut de Radioprotection et de SÛreté Nucléaire (IRSN), PRP-HOM, SRBE, LRTOX, Fontenay-aux Roses, France; Institut de Radioprotection et de SÛreté Nucléaire (IRSN), PRP-HOM, Fontenay-aux Roses, France.
Elie C; Institut de Radioprotection et de SÛreté Nucléaire (IRSN), PRP-HOM, SRBE, LRTOX, Fontenay-aux Roses, France; Institut de Radioprotection et de SÛreté Nucléaire (IRSN), PRP-HOM, Fontenay-aux Roses, France.
Tack K; Institut de Radioprotection et de SÛreté Nucléaire (IRSN), PRP-HOM, SRBE, LRTOX, Fontenay-aux Roses, France; Institut de Radioprotection et de SÛreté Nucléaire (IRSN), PRP-HOM, Fontenay-aux Roses, France.
Benderitter M; Institut de Radioprotection et de SÛreté Nucléaire (IRSN), PRP-HOM, SRBE, Fontenay-aux Roses, France; Institut de Radioprotection et de SÛreté Nucléaire (IRSN), PRP-HOM, Fontenay-aux Roses, France.
Lestaevel P; Institut de Radioprotection et de SÛreté Nucléaire (IRSN), PRP-HOM, SRBE, LRTOX, Fontenay-aux Roses, France; Institut de Radioprotection et de SÛreté Nucléaire (IRSN), PRP-HOM, Fontenay-aux Roses, France.
Legendre A; Institut de Radioprotection et de SÛreté Nucléaire (IRSN), PRP-HOM, SRBE, LRTOX, Fontenay-aux Roses, France; Institut de Radioprotection et de SÛreté Nucléaire (IRSN), PRP-HOM, Fontenay-aux Roses, France.
Souidi M; Institut de Radioprotection et de SÛreté Nucléaire (IRSN), PRP-HOM, SRBE, LRTOX, Fontenay-aux Roses, France; Institut de Radioprotection et de SÛreté Nucléaire (IRSN), PRP-HOM, Fontenay-aux Roses, France. Electronic address: .
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Źródło :
Toxicology letters [Toxicol Lett] 2018 Jan 05; Vol. 282, pp. 64-70. Date of Electronic Publication: 2017 Oct 09.
Typ publikacji :
Journal Article
MeSH Terms :
DNA Methylation/*radiation effects
Epigenesis, Genetic/*radiation effects
Ovary/*radiation effects
Prenatal Exposure Delayed Effects/*chemically induced
Testis/*radiation effects
Uranium/*toxicity
Animals ; Dose-Response Relationship, Radiation ; Female ; Gene Expression Regulation, Developmental/radiation effects ; Male ; Ovary/metabolism ; Pregnancy ; Prenatal Exposure Delayed Effects/genetics ; Rats ; Sex Characteristics ; Testis/metabolism
Czasopismo naukowe
Tytuł :
Genistein Induces Alterations of Epigenetic Modulatory Signatures in Human Cervical Cancer Cells.
Autorzy :
Sundaram MK; School of Life Sciences, Manipal University, Dubai, United Arab Emirates.
Ansari MZ; School of Life Sciences, Manipal University, Dubai, United Arab Emirates.
Al Mutery A; Department of Applied Biology, University of Sharjah, Sharjah, United Arab Emirates.
Ashraf M; School of Life Sciences, Manipal University, Dubai, United Arab Emirates.
Nasab R; School of Life Sciences, Manipal University, Dubai, United Arab Emirates.
Rai S; School of Life Sciences, Manipal University, Dubai, United Arab Emirates.
Rais N; School of Life Sciences, Manipal University, Dubai, United Arab Emirates.
Hussain A; School of Life Sciences, Manipal University, Dubai, United Arab Emirates.
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Źródło :
Anti-cancer agents in medicinal chemistry [Anticancer Agents Med Chem] 2018; Vol. 18 (3), pp. 412-421.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents/*pharmacology
Epigenesis, Genetic/*drug effects
Genistein/*pharmacology
Histone Deacetylase Inhibitors/*pharmacology
Histone Deacetylases/*metabolism
Uterine Cervical Neoplasms/*drug therapy
Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Female ; Gene Expression Regulation, Neoplastic/drug effects ; Genistein/chemical synthesis ; Genistein/chemistry ; HeLa Cells ; Histone Deacetylase Inhibitors/chemical synthesis ; Histone Deacetylase Inhibitors/chemistry ; Humans ; Models, Molecular ; Molecular Structure ; Structure-Activity Relationship ; Uterine Cervical Neoplasms/genetics ; Uterine Cervical Neoplasms/pathology
Czasopismo naukowe
Tytuł :
Glucocorticoids regulate MiR-29c levels in vascular smooth muscle cells through transcriptional and epigenetic mechanisms.
Autorzy :
Chuang TD; Department of Obstetrics and Gynecology, Harbor-UCLA Medical Center, Torrance, CA, United States; LA Biomed Research Institute, Torrance, CA, United States.
Khorram O; Department of Obstetrics and Gynecology, Harbor-UCLA Medical Center, Torrance, CA, United States; LA Biomed Research Institute, Torrance, CA, United States. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2017 Oct 01; Vol. 186, pp. 87-91. Date of Electronic Publication: 2017 Aug 08.
Typ publikacji :
Journal Article
MeSH Terms :
Dexamethasone/*pharmacology
Epigenesis, Genetic/*drug effects
Glucocorticoids/*pharmacology
MicroRNAs/*genetics
Muscle, Smooth, Vascular/*cytology
Myocytes, Smooth Muscle/*drug effects
Transcription, Genetic/*drug effects
Animals ; Cell Culture Techniques ; Cell Line ; DNA Methylation/drug effects ; Myocytes, Smooth Muscle/metabolism ; RNA, Small Interfering/genetics ; Rats
Czasopismo naukowe
Tytuł :
Age-related cataracts: Role of unfolded protein response, Ca mobilization, epigenetic DNA modifications, and loss of Nrf2/Keap1 dependent cytoprotection.
Autorzy :
Periyasamy P; Department of Ophthalmology and Visual Sciences, University of Nebraska Medical Center, Omaha, NE 68198, USA; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, USA. Electronic address: .
Shinohara T; Department of Ophthalmology and Visual Sciences, University of Nebraska Medical Center, Omaha, NE 68198, USA.
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Źródło :
Progress in retinal and eye research [Prog Retin Eye Res] 2017 Sep; Vol. 60, pp. 1-19. Date of Electronic Publication: 2017 Aug 31.
Typ publikacji :
Journal Article; Review; Research Support, N.I.H., Extramural
MeSH Terms :
Calcium/*metabolism
Cataract/*physiopathology
Cytoprotection/*physiology
Epigenesis, Genetic/*physiology
Kelch-Like ECH-Associated Protein 1/*physiology
NF-E2-Related Factor 2/*physiology
Unfolded Protein Response/*physiology
Cataract/metabolism ; Endoplasmic Reticulum Stress/physiology ; Humans ; Lens, Crystalline/metabolism ; Lens, Crystalline/physiopathology ; Reactive Oxygen Species/metabolism
Czasopismo naukowe
Tytuł :
MUC1-C Oncoprotein Integrates a Program of EMT, Epigenetic Reprogramming and Immune Evasion in Human Carcinomas.
Autorzy :
Rajabi H; Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, United States.
Kufe D; Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, United States. Electronic address: .
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Źródło :
Biochimica et biophysica acta. Reviews on cancer [Biochim Biophys Acta Rev Cancer] 2017 Aug; Vol. 1868 (1), pp. 117-122. Date of Electronic Publication: 2017 Mar 14.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Review
MeSH Terms :
Carcinoma/*genetics
Epigenesis, Genetic/*genetics
Epithelial-Mesenchymal Transition/*genetics
Immune Evasion/*genetics
Mucin-1/*genetics
Oncogene Proteins/*genetics
Animals ; Humans
Czasopismo naukowe
Tytuł :
Brain-Derived Neurotrophic Factor Mediated Perfluorooctane Sulfonate Induced-Neurotoxicity via Epigenetics Regulation in SK-N-SH Cells.
Autorzy :
Guo XX; Department of Preventive Medicine, School of Public Health, University of South China, Hengyang 421001, China. .
He QZ; School of Pharmacy and Biology, University of South China, Hengyang 421001, China. .; Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Hengyang 421001, China. .
Li W; Department of Preventive Medicine, School of Public Health, University of South China, Hengyang 421001, China. .
Long DX; Department of Preventive Medicine, School of Public Health, University of South China, Hengyang 421001, China. .
Pan XY; Department of Preventive Medicine, School of Public Health, University of South China, Hengyang 421001, China. .
Chen C; Department of Preventive Medicine, School of Public Health, University of South China, Hengyang 421001, China. .
Zeng HC; Department of Preventive Medicine, School of Public Health, University of South China, Hengyang 421001, China. .; Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Hengyang 421001, China. .
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2017 Apr 24; Vol. 18 (4). Date of Electronic Publication: 2017 Apr 24.
Typ publikacji :
Journal Article
MeSH Terms :
Alkanesulfonic Acids/*toxicity
Brain-Derived Neurotrophic Factor/*metabolism
Environmental Pollutants/*toxicity
Epigenesis, Genetic/*drug effects
Fluorocarbons/*toxicity
Brain-Derived Neurotrophic Factor/genetics ; Cell Line, Tumor ; Cell Survival/drug effects ; DNA Methylation/drug effects ; DNA-Cytosine Methylases/genetics ; DNA-Cytosine Methylases/metabolism ; Enzyme-Linked Immunosorbent Assay ; Gene Expression/drug effects ; Humans ; MicroRNAs/metabolism ; Promoter Regions, Genetic ; RNA, Messenger/metabolism ; Real-Time Polymerase Chain Reaction
Czasopismo naukowe
Tytuł :
Epigenetics: A primer for clinicians.
Autorzy :
Paluch BE; Department of Pharmacology, Center for Pharmacology and Genetics Building (CGP), Roswell Park Cancer Institute (RPCI), Elm and Carlton Street, 14263 Buffalo, NY, USA. Electronic address: .
Naqash AR; Catholic Health, State University of New York at Buffalo (SUNY), 2157 Main Street, 14214 Buffalo, NY, USA. Electronic address: .
Brumberger Z; University at Buffalo State University of New York, School of Medicine and Biomedical Sciences, 3435 Main Street, 14260 Buffalo, NY, USA.
Nemeth MJ; Department of Medicine, RPCI, Elm and Carlton Street, 14263 Buffalo, NY, USA.
Griffiths EA; Department of Pharmacology, Center for Pharmacology and Genetics Building (CGP), Roswell Park Cancer Institute (RPCI), Elm and Carlton Street, 14263 Buffalo, NY, USA; Department of Medicine, RPCI, Elm and Carlton Street, 14263 Buffalo, NY, USA; Leukemia Division, RPCI, Elm and Carlton Street, 14263 Buffalo, NY, USA. Electronic address: .
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Źródło :
Blood reviews [Blood Rev] 2016 Jul; Vol. 30 (4), pp. 285-95. Date of Electronic Publication: 2016 Feb 26.
Typ publikacji :
Journal Article; Review; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Epigenesis, Genetic/*genetics
Cell Differentiation ; Humans
Czasopismo naukowe
Tytuł :
The promise of epigenomic therapeutics in pancreatic cancer.
Autorzy :
Lomberk GA; Laboratory of Epigenetics & Chromatin Dynamics, Gastroenterology Research Unit, Departments of Biochemistry & Molecular Biology, Biophysics, & Medicine, Mayo Clinic, Rochester, MN, USA.
Iovanna J; Centre de Recherche en Cancérologie de Marseille (CRCM), INSERM U1068, CNRS UMR 7258, Aix-Marseille Université & Institut Paoli-Calmettes, Parc Scientifique et Technologique de Luminy, Marseille, France.
Urrutia R; Laboratory of Epigenetics & Chromatin Dynamics, Gastroenterology Research Unit, Departments of Biochemistry & Molecular Biology, Biophysics, & Medicine, Mayo Clinic, Rochester, MN, USA.
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Źródło :
Epigenomics [Epigenomics] 2016 Jun; Vol. 8 (6), pp. 831-42. Date of Electronic Publication: 2016 Jun 23.
Typ publikacji :
Journal Article; Review; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents/*pharmacology
Carcinoma, Pancreatic Ductal/*drug therapy
Epigenesis, Genetic/*drug effects
Pancreatic Neoplasms/*drug therapy
Animals ; Carcinoma, Pancreatic Ductal/genetics ; CpG Islands ; DNA Methylation ; Gene Expression Regulation, Neoplastic ; Humans ; Molecular Targeted Therapy ; Pancreatic Neoplasms/genetics
Czasopismo naukowe
Tytuł :
Differential genotoxic and epigenotoxic effects of graphene family nanomaterials (GFNs) in human bronchial epithelial cells.
Autorzy :
Chatterjee N; School of Environmental Engineering, Graduate School of Energy and Environmental System Engineering, University of Seoul, 163 Siripdaero, Dongdaemun-gu, Seoul 130-743, Republic of Korea.
Yang J; School of Environmental Engineering, Graduate School of Energy and Environmental System Engineering, University of Seoul, 163 Siripdaero, Dongdaemun-gu, Seoul 130-743, Republic of Korea.
Choi J; School of Environmental Engineering, Graduate School of Energy and Environmental System Engineering, University of Seoul, 163 Siripdaero, Dongdaemun-gu, Seoul 130-743, Republic of Korea. Electronic address: .
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Źródło :
Mutation research. Genetic toxicology and environmental mutagenesis [Mutat Res Genet Toxicol Environ Mutagen] 2016 Mar; Vol. 798-799, pp. 1-10. Date of Electronic Publication: 2016 Feb 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Damage*
Bronchi/*drug effects
Epigenesis, Genetic/*drug effects
Graphite/*toxicity
Mutagens/*toxicity
Nanostructures/*toxicity
Respiratory Mucosa/*drug effects
Cell Line ; DNA (Cytosine-5-)-Methyltransferases ; DNA Methylation/drug effects ; DNA Repair/drug effects ; Epithelial Cells/drug effects ; Genes, Regulator/drug effects ; Humans
Czasopismo naukowe
Tytuł :
Expression of epigenetic modifiers is not significantly altered by exposure to secondhand smoke.
Autorzy :
Tommasi S; Department of Preventive Medicine, USC Keck School of Medicine, University of Southern California, M/C 9603, Los Angeles, CA 90033, USA. Electronic address: .
Zheng A; Department of Preventive Medicine, USC Keck School of Medicine, University of Southern California, M/C 9603, Los Angeles, CA 90033, USA.
Besaratinia A; Department of Preventive Medicine, USC Keck School of Medicine, University of Southern California, M/C 9603, Los Angeles, CA 90033, USA.
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Źródło :
Lung cancer (Amsterdam, Netherlands) [Lung Cancer] 2015 Dec; Vol. 90 (3), pp. 598-603. Date of Electronic Publication: 2015 Oct 27.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Epigenesis, Genetic*
Gene Expression Regulation, Neoplastic*
Tobacco Smoke Pollution/*adverse effects
Acetylation ; Animals ; Biomarkers ; DNA (Cytosine-5-)-Methyltransferases/metabolism ; Histones/metabolism ; Lung/metabolism ; Male ; Mice
Czasopismo naukowe
Tytuł :
Prenatal cocaine exposure impairs cognitive function of progeny via insulin growth factor II epigenetic regulation.
Autorzy :
Zhao Q; National Chengdu Center for Safety Evaluation of Drugs, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu 610041, China.
Hou J; National Chengdu Center for Safety Evaluation of Drugs, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu 610041, China.
Chen B; National Chengdu Center for Safety Evaluation of Drugs, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu 610041, China.
Shao X; National Chengdu Center for Safety Evaluation of Drugs, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu 610041, China.
Zhu R; National Chengdu Center for Safety Evaluation of Drugs, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu 610041, China.
Bu Q; National Chengdu Center for Safety Evaluation of Drugs, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu 610041, China.
Gu H; National Chengdu Center for Safety Evaluation of Drugs, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu 610041, China.
Li Y; National Chengdu Center for Safety Evaluation of Drugs, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu 610041, China.
Zhang B; National Chengdu Center for Safety Evaluation of Drugs, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu 610041, China.
Du C; National Chengdu Center for Safety Evaluation of Drugs, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu 610041, China.
Fu D; National Chengdu Center for Safety Evaluation of Drugs, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu 610041, China.
Kong J; National Chengdu Center for Safety Evaluation of Drugs, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu 610041, China.
Luo L; National Chengdu Center for Safety Evaluation of Drugs, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu 610041, China.
Long H; National Chengdu Center for Safety Evaluation of Drugs, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu 610041, China.
Li H; National Chengdu Center for Safety Evaluation of Drugs, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu 610041, China.
Deng Y; National Chengdu Center for Safety Evaluation of Drugs, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu 610041, China.
Zhao Y; National Chengdu Center for Safety Evaluation of Drugs, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu 610041, China.
Cen X; National Chengdu Center for Safety Evaluation of Drugs, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu 610041, China. Electronic address: .
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Źródło :
Neurobiology of disease [Neurobiol Dis] 2015 Oct; Vol. 82, pp. 54-65. Date of Electronic Publication: 2015 Jun 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Epigenesis, Genetic*
Cocaine/*pharmacology
Cognition/*drug effects
Insulin-Like Growth Factor II/*genetics
Prenatal Exposure Delayed Effects/*genetics
Animals ; Calcium-Calmodulin-Dependent Protein Kinase Type 2/metabolism ; Cognition/physiology ; DNA Methylation/drug effects ; Female ; Hippocampus/drug effects ; Hippocampus/metabolism ; Insulin-Like Growth Factor II/metabolism ; Insulin-Like Growth Factor II/pharmacology ; Maze Learning/drug effects ; Maze Learning/physiology ; Mice ; Phosphorylation ; Pregnancy ; Prenatal Exposure Delayed Effects/metabolism ; Prenatal Exposure Delayed Effects/psychology
Czasopismo naukowe

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