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Tytuł :
Reserpine inhibits DNA repair, cell proliferation, invasion and induces apoptosis in oral carcinogenesis via modulation of TGF-β signaling.
Autorzy :
Ramu AK; Department of Biochemistry and Biotechnology, Centre for Research and Development, PRIST Deemed University, Vallam, Thanjavur, Tamil Nadu, India. Electronic address: .
Ali D; Department of Zoology, College of Science King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia.
Alarifi S; Department of Zoology, College of Science King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia.
Syed Abuthakir MH; Biochematics Lab, Department of Bioinformatics, Bharathiar University, Coimbatore, India.
Ahmed Abdul BA; Department of Biochemistry and Biotechnology, Centre for Research and Development, PRIST Deemed University, Vallam, Thanjavur, Tamil Nadu, India. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Jan 01; Vol. 264, pp. 118730. Date of Electronic Publication: 2020 Nov 06.
Typ publikacji :
Journal Article
MeSH Terms :
Signal Transduction*/drug effects
Apoptosis/*drug effects
Carcinogenesis/*pathology
DNA Repair/*drug effects
Mouth Neoplasms/*pathology
Reserpine/*pharmacology
Transforming Growth Factor beta/*metabolism
9,10-Dimethyl-1,2-benzanthracene ; Animals ; Carcinogenesis/drug effects ; Cell Proliferation/drug effects ; Cricetinae ; Down-Regulation/drug effects ; Down-Regulation/genetics ; Male ; Molecular Docking Simulation ; Mouth Mucosa/drug effects ; Mouth Mucosa/pathology ; Neoplasm Invasiveness ; Neoplasm Proteins/metabolism ; Reserpine/chemistry
Czasopismo naukowe
Tytuł :
Effects of rapamycin and AZD3463 combination on apoptosis, autophagy, and cell cycle for resistance control in breast cancer.
Autorzy :
Ozates NP; Department of Medical Biology, Ege University Medicine Faculty, İzmir, Turkey.
Soğutlu F; Department of Medical Biology, Ege University Medicine Faculty, İzmir, Turkey.
Lerminoglu F; Department of Toxicology, Ege University Pharmacy Faculty, Izmir, Turkey.
Demir B; Department of Toxicology, Ege University Pharmacy Faculty, Izmir, Turkey.
Gunduz C; Department of Medical Biology, Ege University Medicine Faculty, İzmir, Turkey.
Shademan B; Department of Medical Biology, Ege University Medicine Faculty, İzmir, Turkey.
Avci CB; Department of Medical Biology, Ege University Medicine Faculty, İzmir, Turkey. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Jan 01; Vol. 264, pp. 118643. Date of Electronic Publication: 2020 Oct 24.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Resistance, Neoplasm*/drug effects
Apoptosis/*drug effects
Autophagy/*drug effects
Breast Neoplasms/*pathology
Cell Cycle/*drug effects
Sirolimus/*pharmacology
Autophagosomes/drug effects ; Autophagosomes/metabolism ; Breast Neoplasms/genetics ; Cell Survival/drug effects ; Female ; Gene Expression Regulation, Neoplastic/drug effects ; Glycolysis/drug effects ; Humans ; Inhibitory Concentration 50 ; MCF-7 Cells ; Oxygen Consumption/drug effects ; Phenotype
Czasopismo naukowe
Tytuł :
Paeonol inhibits apoptosis of vascular smooth muscle cells via up-regulation of autophagy by activating class III PI3K/Beclin-1 signaling pathway.
Autorzy :
Liu Y; School of Pharmacy, Anhui University of Chinese Medicine, Hefei, Anhui 230012, China; Key Laboratory of Xin'an Medicine, Ministry of Education, Hefei, Anhui 230038, China; Anhui Key Laboratory for Research and Development of Traditional Chinese Medicine, Hefei, Anhui 230012, China.
Song A; School of Pharmacy, Anhui University of Chinese Medicine, Hefei, Anhui 230012, China.
Wu H; School of Pharmacy, Anhui University of Chinese Medicine, Hefei, Anhui 230012, China; Key Laboratory of Xin'an Medicine, Ministry of Education, Hefei, Anhui 230038, China; Anhui Key Laboratory for Research and Development of Traditional Chinese Medicine, Hefei, Anhui 230012, China.
Sun Y; School of Pharmacy, Anhui University of Chinese Medicine, Hefei, Anhui 230012, China.
Dai M; School of Pharmacy, Anhui University of Chinese Medicine, Hefei, Anhui 230012, China; Key Laboratory of Xin'an Medicine, Ministry of Education, Hefei, Anhui 230038, China; Anhui Key Laboratory for Research and Development of Traditional Chinese Medicine, Hefei, Anhui 230012, China. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Jan 01; Vol. 264, pp. 118714. Date of Electronic Publication: 2020 Nov 04.
Typ publikacji :
Journal Article
MeSH Terms :
Autophagy*/drug effects
Up-Regulation*/drug effects
Acetophenones/*pharmacology
Apoptosis/*drug effects
Beclin-1/*metabolism
Muscle, Smooth, Vascular/*cytology
Myocytes, Smooth Muscle/*cytology
Phosphatidylinositol 3-Kinases/*metabolism
Animals ; Aorta/metabolism ; Apolipoproteins E/deficiency ; Atherosclerosis/metabolism ; Atherosclerosis/pathology ; Caspase 3/metabolism ; Lipoproteins, LDL ; Male ; Mice, Inbred C57BL ; Microtubule-Associated Proteins/metabolism ; Models, Biological ; Myocytes, Smooth Muscle/drug effects ; Myocytes, Smooth Muscle/metabolism ; Myocytes, Smooth Muscle/ultrastructure ; Sequestosome-1 Protein/metabolism ; Signal Transduction/drug effects
Czasopismo naukowe
Tytuł :
Pyridoxal kinase inhibition by artemisinins down-regulates inhibitory neurotransmission.
Autorzy :
Kasaragod VB; Institute of Structural Biology, Rudolf Virchow Center for Integrative and Translational Bioimaging, University of Würzburg, 97080 Würzburg, Germany; .
Pacios-Michelena A; Institute of Structural Biology, Rudolf Virchow Center for Integrative and Translational Bioimaging, University of Würzburg, 97080 Würzburg, Germany.
Schaefer N; Institute for Clinical Neurobiology, University of Würzburg, 97078 Würzburg, Germany.
Zheng F; Institute of Physiology and Pathophysiology, Friedrich Alexander University Erlangen-Nürnberg, 91054 Erlangen, Germany.
Bader N; Institute of Structural Biology, Rudolf Virchow Center for Integrative and Translational Bioimaging, University of Würzburg, 97080 Würzburg, Germany.
Alzheimer C; Institute of Physiology and Pathophysiology, Friedrich Alexander University Erlangen-Nürnberg, 91054 Erlangen, Germany.
Villmann C; Institute for Clinical Neurobiology, University of Würzburg, 97078 Würzburg, Germany.
Schindelin H; Institute of Structural Biology, Rudolf Virchow Center for Integrative and Translational Bioimaging, University of Würzburg, 97080 Würzburg, Germany; .
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Dec 29; Vol. 117 (52), pp. 33235-33245. Date of Electronic Publication: 2020 Dec 14.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Down-Regulation*/drug effects
Artemisinins/*pharmacology
Neural Inhibition/*drug effects
Protein Kinase Inhibitors/*pharmacology
Pyridoxal Kinase/*antagonists & inhibitors
Synaptic Transmission/*drug effects
Adenosine Triphosphate/analogs & derivatives ; Adenosine Triphosphate/metabolism ; Animals ; Artemisinins/chemistry ; Binding Sites ; Electrophysiological Phenomena/drug effects ; Female ; GABAergic Neurons/drug effects ; GABAergic Neurons/metabolism ; Glutamate Decarboxylase/metabolism ; Male ; Mice, Inbred C57BL ; Models, Biological ; Models, Molecular ; Protein Kinase Inhibitors/chemistry ; Pyridoxal Kinase/chemistry ; Pyridoxal Kinase/metabolism ; Synapses/drug effects ; Synapses/metabolism ; gamma-Aminobutyric Acid/biosynthesis
Czasopismo naukowe
Tytuł :
Folic acid attenuates remodeling and dysfunction in the aging heart through the ER stress pathway.
Autorzy :
Ye S; Department of Cardiology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Zhou X; Department of Cardiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Chen P; Department of Cardiology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Lin JF; Department of Cardiology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Jan 01; Vol. 264, pp. 118718. Date of Electronic Publication: 2020 Nov 05.
Typ publikacji :
Journal Article
MeSH Terms :
Ventricular Remodeling*/drug effects
Aging/*pathology
Endoplasmic Reticulum Stress/*drug effects
Folic Acid/*pharmacology
Heart/*physiopathology
Animals ; Cardiotonic Agents/pharmacology ; Cardiotonic Agents/therapeutic use ; Cell Line ; Fibrosis ; Heart/drug effects ; Heart Ventricles/drug effects ; Heart Ventricles/pathology ; Heart Ventricles/physiopathology ; Hypertrophy, Left Ventricular/drug therapy ; Hypertrophy, Left Ventricular/pathology ; Hypertrophy, Left Ventricular/physiopathology ; Male ; Mice, Inbred C57BL ; Myocytes, Cardiac/drug effects ; Myocytes, Cardiac/metabolism ; Myocytes, Cardiac/pathology ; Oxidative Stress/drug effects ; Systole/drug effects
Czasopismo naukowe
Tytuł :
Clinical and laboratory characteristics of children under five hospitalized with diarrhea and bacteremia.
Autorzy :
Shahunja KM; International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh.
Ahmed T; International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh.
Hossain MI; International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh.
Islam MM; International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh.
Monjory MB; International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh.
Shahid ASMSB; International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh.
Faruque ASG; International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh.
Chisti MJ; International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh.
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Źródło :
PloS one [PLoS One] 2020 Dec 02; Vol. 15 (12), pp. e0243128. Date of Electronic Publication: 2020 Dec 02 (Print Publication: 2020).
Typ publikacji :
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Klebsiella*/drug effects
Klebsiella*/isolation & purification
Anti-Bacterial Agents/*pharmacology
Bacteremia/*mortality
Bacteria/*drug effects
Bacteria/*isolation & purification
Diarrhea/*microbiology
Bacteremia/microbiology ; Bacteria/classification ; Bangladesh/epidemiology ; Child, Preschool ; Cross-Sectional Studies ; Diarrhea/mortality ; Drug Resistance, Multiple, Bacterial ; Escherichia coli/drug effects ; Escherichia coli/isolation & purification ; Female ; Hospitalization ; Humans ; Infant ; Infant, Newborn ; Male ; Pseudomonas/drug effects ; Pseudomonas/isolation & purification ; Retrospective Studies ; Salmonella typhi/drug effects ; Salmonella typhi/isolation & purification ; Staphylococcus/drug effects ; Staphylococcus/isolation & purification ; Survival Analysis
Czasopismo naukowe
Tytuł :
A specific inhibitor of polo-like kinase 1, GSK461364A, suppresses proliferation of Raji Burkitt's lymphoma cells through mediating cell cycle arrest, DNA damage, and apoptosis.
Autorzy :
Ergul M; Department of Biochemistry, Faculty of Pharmacy, Sivas Cumhuriyet University, Sivas, Turkey. Electronic address: .
Bakar-Ates F; Department of Biochemistry, Faculty of Pharmacy, Ankara University, Ankara, Turkey.
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Źródło :
Chemico-biological interactions [Chem Biol Interact] 2020 Dec 01; Vol. 332, pp. 109288. Date of Electronic Publication: 2020 Oct 17.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis*/drug effects
DNA Damage*
Burkitt Lymphoma/*pathology
Cell Cycle Checkpoints/*drug effects
Cell Cycle Proteins/*antagonists & inhibitors
Protein Kinase Inhibitors/*pharmacology
Protein-Serine-Threonine Kinases/*antagonists & inhibitors
Proto-Oncogene Proteins/*antagonists & inhibitors
Thiophenes/*pharmacology
Animals ; Antioxidants/metabolism ; Cell Cycle Proteins/metabolism ; Cell Line, Tumor ; Cell Proliferation/drug effects ; G2 Phase/drug effects ; Humans ; Mice ; Mitosis/drug effects ; Oxidants/metabolism ; Protein-Serine-Threonine Kinases/metabolism ; Proto-Oncogene Proteins/metabolism
Czasopismo naukowe
Tytuł :
Molecular mechanisms underlying the effects of the small molecule AMC-04 on apoptosis: Roles of the activating transcription factor 4-C/EBP homologous protein-death receptor 5 pathway.
Autorzy :
Kim SY; Biomedical Research Center, ASAN Institute for Life Sciences, ASAN Medical Center, Seoul, 05505, Republic of Korea.
Hwang S; Convergence Medicine Research Center (CREDIT), ASAN Institute for Life Sciences, ASAN Medical Center, Seoul, 05505, Republic of Korea.
Choi MK; Convergence Medicine Research Center (CREDIT), ASAN Institute for Life Sciences, ASAN Medical Center, Seoul, 05505, Republic of Korea.
Park S; Convergence Medicine Research Center (CREDIT), ASAN Institute for Life Sciences, ASAN Medical Center, Seoul, 05505, Republic of Korea.
Nam KY; Pharosibio, Heungan Daero 427, Anyang, Gyeonggido, Republic of Korea. Electronic address: .
Kim I; Convergence Medicine Research Center (CREDIT), ASAN Institute for Life Sciences, ASAN Medical Center, Seoul, 05505, Republic of Korea; Department of Convergence Medicine, University of Ulsan College of Medicine, Seoul, 05505, Republic of Korea. Electronic address: .
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Źródło :
Chemico-biological interactions [Chem Biol Interact] 2020 Dec 01; Vol. 332, pp. 109277. Date of Electronic Publication: 2020 Sep 29.
Typ publikacji :
Journal Article
MeSH Terms :
Signal Transduction*/drug effects
Activating Transcription Factor 4/*metabolism
Apoptosis/*drug effects
Receptors, TNF-Related Apoptosis-Inducing Ligand/*metabolism
Small Molecule Libraries/*pharmacology
Transcription Factor CHOP/*metabolism
Cell Line, Tumor ; Endoplasmic Reticulum Stress/drug effects ; Endoplasmic Reticulum Stress/genetics ; Enzyme Inhibitors/pharmacology ; Histone Methyltransferases/antagonists & inhibitors ; Histone Methyltransferases/metabolism ; Humans ; Reactive Oxygen Species/metabolism ; Small Molecule Libraries/chemistry ; Unfolded Protein Response/drug effects ; Unfolded Protein Response/genetics ; Up-Regulation/drug effects ; Up-Regulation/genetics
Czasopismo naukowe
Tytuł :
Hydroxychloroquine can potentially interfere with immune function in COVID-19 patients: Mechanisms and insights.
Autorzy :
Devarajan A; UCLA Cardiac Arrhythmia Center, University of California, Los Angeles, CA, USA; Neurocardiology Research Center of Excellence, University of California, Los Angeles, CA, USA. Electronic address: .
Vaseghi M; UCLA Cardiac Arrhythmia Center, University of California, Los Angeles, CA, USA; Neurocardiology Research Center of Excellence, University of California, Los Angeles, CA, USA.
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Źródło :
Redox biology [Redox Biol] 2021 Jan; Vol. 38, pp. 101810. Date of Electronic Publication: 2020 Nov 30.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Review
MeSH Terms :
Antiviral Agents*/adverse effects
Antiviral Agents*/therapeutic use
Autophagic Cell Death*/drug effects
Autophagic Cell Death*/immunology
COVID-19*/drug therapy
COVID-19*/epidemiology
COVID-19*/immunology
COVID-19*/pathology
Hydroxychloroquine*/adverse effects
Hydroxychloroquine*/therapeutic use
Pandemics*
Antigen Presentation/*drug effects
SARS-CoV-2/*immunology
Humans ; Oxidation-Reduction/drug effects
Czasopismo naukowe
Tytuł :
Mitochondrial Glutamine Metabolism Determines Senescence Induction After Chemotherapy.
Autorzy :
Kim B; Department of Biochemistry, The Catholic University of Korea, Seoul, Republic of Korea.; Department of Biomedicine & Health Sciences, The Catholic University of Korea, Seoul, Republic of Korea.; Institute for Aging and Metabolic Diseases, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Gwak J; Department of Biochemistry, The Catholic University of Korea, Seoul, Republic of Korea.; Department of Biomedicine & Health Sciences, The Catholic University of Korea, Seoul, Republic of Korea.; Institute for Aging and Metabolic Diseases, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Lee EK; Department of Biochemistry, The Catholic University of Korea, Seoul, Republic of Korea.; Institute for Aging and Metabolic Diseases, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Jeong SM; Department of Biochemistry, The Catholic University of Korea, Seoul, Republic of Korea .; Department of Biomedicine & Health Sciences, The Catholic University of Korea, Seoul, Republic of Korea .; Institute for Aging and Metabolic Diseases, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea .
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Źródło :
Anticancer research [Anticancer Res] 2020 Dec; Vol. 40 (12), pp. 6891-6897.
Typ publikacji :
Journal Article
MeSH Terms :
Cellular Senescence*/drug effects
Cellular Senescence*/genetics
Antineoplastic Agents/*pharmacology
Glutamine/*metabolism
Mitochondria/*drug effects
Mitochondria/*metabolism
Antineoplastic Agents/therapeutic use ; Biomarkers ; Cell Line, Tumor ; DNA Damage ; Dose-Response Relationship, Drug ; Humans ; Signal Transduction/drug effects
Czasopismo naukowe
Tytuł :
The effects of nicotine and cannabis co-use during adolescence and young adulthood on white matter cerebral blood flow estimates.
Autorzy :
Courtney KE; Department of Psychiatry, University of California San Diego, 9500 Gilman Drive, MC 0405, La Jolla, CA, 92093, USA.
Baca R; Department of Psychiatry, University of California San Diego, 9500 Gilman Drive, MC 0405, La Jolla, CA, 92093, USA.
Doran N; Department of Psychiatry, University of California San Diego, 9500 Gilman Drive, MC 0405, La Jolla, CA, 92093, USA.; Veterans Affairs San Diego Healthcare System, La Jolla, CA, USA.
Jacobson A; Department of Radiology, University of California San Diego, La Jolla, CA, USA.
Liu TT; Department of Radiology, University of California San Diego, La Jolla, CA, USA.
Jacobus J; Department of Psychiatry, University of California San Diego, 9500 Gilman Drive, MC 0405, La Jolla, CA, 92093, USA. .
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Źródło :
Psychopharmacology [Psychopharmacology (Berl)] 2020 Dec; Vol. 237 (12), pp. 3615-3624. Date of Electronic Publication: 2020 Aug 15.
Typ publikacji :
Journal Article
MeSH Terms :
White Matter*/blood supply
White Matter*/diagnostic imaging
White Matter*/drug effects
Cannabis/*toxicity
Cerebrovascular Circulation/*drug effects
Marijuana Smoking/*adverse effects
Nicotine/*toxicity
Adolescent ; Adult ; Anisotropy ; Cerebrovascular Circulation/physiology ; Diffusion Tensor Imaging ; Drug Synergism ; Female ; Humans ; Male ; Nerve Net/blood supply ; Nerve Net/diagnostic imaging ; Nerve Net/drug effects ; Neuroimaging/methods ; Nicotine/administration & dosage ; Spin Labels ; Young Adult
Czasopismo naukowe
Tytuł :
Hydrogen sulfide inhibits endoplasmic reticulum stress through the GRP78/mTOR pathway in rat chondrocytes subjected to oxidative stress.
Autorzy :
Wu J; Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150086, P.R. China.
Yang F; Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150086, P.R. China.
Zhang X; Department of Orthopedic Surgery, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, P.R. China.
Chen G; Department of Orthopedic Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150086, P.R. China.
Zou J; Department of Orthopedic Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150086, P.R. China.
Yin L; Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150086, P.R. China.
Yang D; Department of Orthopedic Surgery, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, P.R. China.
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Źródło :
International journal of molecular medicine [Int J Mol Med] 2021 Apr; Vol. 47 (4). Date of Electronic Publication: 2021 Feb 04.
Typ publikacji :
Journal Article
MeSH Terms :
Signal Transduction*/drug effects
Chondrocytes/*metabolism
Chondrocytes/*pathology
Endoplasmic Reticulum Stress/*drug effects
Heat-Shock Proteins/*metabolism
Hydrogen Sulfide/*pharmacology
Oxidative Stress/*drug effects
TOR Serine-Threonine Kinases/*metabolism
Animals ; Apoptosis/drug effects ; Autophagy/drug effects ; Cell Hypoxia/drug effects ; Cell Survival/drug effects ; Chloroquine/pharmacology ; Chondrocytes/drug effects ; Cytoprotection/drug effects ; Male ; Morpholines/chemistry ; Morpholines/pharmacology ; Organothiophosphorus Compounds/chemistry ; Organothiophosphorus Compounds/pharmacology ; Peroxides/pharmacology ; Protective Agents/pharmacology ; Rats, Sprague-Dawley ; Reactive Oxygen Species/metabolism
Czasopismo naukowe
Tytuł :
A chronicle of SARS-CoV-2: Seasonality, environmental fate, transport, inactivation, and antiviral drug resistance.
Autorzy :
Kumar M; Discipline of Earth Science, Indian Institute of Technology Gandhinagar, Gujarat 382 355, India. Electronic address: .
Mazumder P; Centre for the Environment, Indian Institute of Technology Guwahati, Guwahati 781039, Assam, India.
Mohapatra S; Environmnetal Science and Engineering Department, Indian Institute of Technology Bombay, Mumbai 400076, India.
Kumar Thakur A; Discipline of Earth Science, Indian Institute of Technology Gandhinagar, Gujarat 382 355, India.
Dhangar K; Discipline of Earth Science, Indian Institute of Technology Gandhinagar, Gujarat 382 355, India.
Taki K; Discipline of Civil Engineering, Indian Institute of Technology Gandhinagar, Gujarat 382 355, India.
Mukherjee S; Discipline of Earth Science, Indian Institute of Technology Gandhinagar, Gujarat 382 355, India.
Kumar Patel A; Discipline of Earth Science, Indian Institute of Technology Gandhinagar, Gujarat 382 355, India.
Bhattacharya P; Department of Sustainable Development, Environmental Science and Engineering, KTH Royal Institute of Technology, Teknikringen 10B, SE-10044 Stockholm, Sweden.
Mohapatra P; Discipline of Civil Engineering, Indian Institute of Technology Gandhinagar, Gujarat 382 355, India.
Rinklebe J; Laboratory of Soil- and Groundwater-Management, School of Architecture and Civil Engineering, University of Wuppertal, Wuppertal 42285, Germany; Department of Environment, Energy and Geoinformatics, University of Sejong, Seoul, South Korea.
Kitajima M; Division of Environmental Engineering, Hokkaido University, Hokkaido 060-8628, Japan.
Hai FI; Wollongong, Strategic Water Infrastructure Laboratory, School of Civil, Mining and Environmental Engineering, University of Wollongong, NSW 2522, Australia.
Khursheed A; Department of Civil Engineering, King Saud University, Riyadh, Saudi Arabia.
Furumai H; Research Centre for Water Environment Technology, Graduate School of Engineering, The University of Tokyo, Tokyo 113-8656, Japan.
Sonne C; Department of Bioscience, Aarhus University, Frederiksborgvej 399, PO Box 358, DK-4000 Roskilde, Denmark.
Kuroda K; Department of Environmental and Civil Engineering, Toyama Prefectural University, Toyama 9390398, Japan.
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Źródło :
Journal of hazardous materials [J Hazard Mater] 2021 Mar 05; Vol. 405, pp. 124043. Date of Electronic Publication: 2020 Oct 06.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Antiviral Agents*/chemistry
Antiviral Agents*/therapeutic use
Antiviral Agents*/toxicity
Environmental Microbiology*
Environmental Pollutants*/chemistry
Environmental Pollutants*/therapeutic use
Environmental Pollutants*/toxicity
SARS-CoV-2*/drug effects
SARS-CoV-2*/pathogenicity
Virus Inactivation*/drug effects
Virus Inactivation*/radiation effects
Drug Resistance, Viral/*drug effects
Adsorption ; Animals ; Aquatic Organisms/drug effects ; COVID-19/drug therapy ; COVID-19/epidemiology ; COVID-19/etiology ; Ecotoxicology ; Humans ; Seasons ; Water Purification
Czasopismo naukowe
Tytuł :
Repeated radon exposure induced lung injury and epithelial-mesenchymal transition through the PI3K/AKT/mTOR pathway in human bronchial epithelial cells and mice.
Autorzy :
Chen H; State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Soochow University, Suzhou, 215123, China; Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Suzhou, 215123, China.
Chen N; State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Soochow University, Suzhou, 215123, China; Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Suzhou, 215123, China.
Li F; PLA Rocket Characteristic Medical Center, Beijing, 100088, China.
Sun L; State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Soochow University, Suzhou, 215123, China; Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Suzhou, 215123, China.
Du J; Department of Radiation Medicine, Faculty of Naval Medicine, Second Military Medical University, Shanghai, 200433, China.
Chen Y; Department of Radiation Medicine, Faculty of Naval Medicine, Second Military Medical University, Shanghai, 200433, China.
Cheng F; PLA Rocket Characteristic Medical Center, Beijing, 100088, China.
Li Y; State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Soochow University, Suzhou, 215123, China; Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Suzhou, 215123, China.
Tian S; State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Soochow University, Suzhou, 215123, China; Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Suzhou, 215123, China.
Jiang Q; PLA Rocket Characteristic Medical Center, Beijing, 100088, China.
Cui F; State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Soochow University, Suzhou, 215123, China; Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Suzhou, 215123, China. Electronic address: .
Tu Y; State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Soochow University, Suzhou, 215123, China; Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Suzhou, 215123, China. Electronic address: .
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Źródło :
Toxicology letters [Toxicol Lett] 2020 Nov 01; Vol. 334, pp. 4-13. Date of Electronic Publication: 2020 Sep 16.
Typ publikacji :
Journal Article
MeSH Terms :
Lung*/drug effects
Lung*/metabolism
Lung*/pathology
Air Pollutants, Radioactive/*toxicity
Epithelial Cells/*drug effects
Epithelial-Mesenchymal Transition/*drug effects
Lung Injury/*chemically induced
Radon/*toxicity
Animals ; Cell Line ; Cell Movement/drug effects ; Cell Proliferation/drug effects ; Dose-Response Relationship, Radiation ; Humans ; Inhalation Exposure/adverse effects ; Lung Injury/metabolism ; Lung Injury/pathology ; Mice ; Mice, Inbred BALB C ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Radon Daughters/toxicity ; Signal Transduction ; TOR Serine-Threonine Kinases/metabolism
Czasopismo naukowe
Tytuł :
Interleukin-4-loaded hydrogel scaffold regulates macrophages polarization to promote bone mesenchymal stem cells osteogenic differentiation via TGF-β1/Smad pathway for repair of bone defect.
Autorzy :
Zhang J; State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Shi H; State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Zhang N; State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Hu L; State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Jing W; State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Pan J; State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
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Źródło :
Cell proliferation [Cell Prolif] 2020 Oct; Vol. 53 (10), pp. e12907. Date of Electronic Publication: 2020 Sep 19.
Typ publikacji :
Journal Article
MeSH Terms :
Bone Regeneration*/drug effects
Cell Differentiation/*drug effects
Hydrogels/*chemistry
Interleukin-4/*pharmacology
Osteogenesis/*drug effects
Signal Transduction/*drug effects
Tissue Scaffolds/*chemistry
Animals ; Apoptosis/drug effects ; Culture Media, Conditioned/pharmacology ; Interleukin-4/chemistry ; Interleukin-4/metabolism ; Macrophage Activation/drug effects ; Macrophages/cytology ; Macrophages/metabolism ; Male ; Mesenchymal Stem Cells/cytology ; Mesenchymal Stem Cells/metabolism ; Mice ; Polysaccharides, Bacterial/chemistry ; RAW 264.7 Cells ; Rats ; Rats, Sprague-Dawley ; Smad Proteins/metabolism ; Tissue Engineering ; Transforming Growth Factor beta1/metabolism
Czasopismo naukowe
Tytuł :
Protective role of wogonin against cadmium induced testicular toxicity: Involvement of antioxidant, anti-inflammatory and anti-apoptotic pathways.
Autorzy :
Yu W; Andrology, Nanjing University Medical School Affiliated Nanjing Drum Tower Hospital, Nanjing 210009, Jiangsu, China.
Xu Z; Andrology, Nanjing University Medical School Affiliated Nanjing Drum Tower Hospital, Nanjing 210009, Jiangsu, China.
Gao Q; Andrology, Nanjing University Medical School Affiliated Nanjing Drum Tower Hospital, Nanjing 210009, Jiangsu, China.
Xu Y; Andrology, Nanjing University Medical School Affiliated Nanjing Drum Tower Hospital, Nanjing 210009, Jiangsu, China.
Wang B; Andrology, Nanjing University Medical School Affiliated Nanjing Drum Tower Hospital, Nanjing 210009, Jiangsu, China.
Dai Y; Andrology, Nanjing University Medical School Affiliated Nanjing Drum Tower Hospital, Nanjing 210009, Jiangsu, China. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2020 Oct 01; Vol. 258, pp. 118192. Date of Electronic Publication: 2020 Aug 08.
Typ publikacji :
Journal Article
MeSH Terms :
Signal Transduction*/drug effects
Anti-Inflammatory Agents/*pharmacology
Antioxidants/*pharmacology
Apoptosis/*drug effects
Cadmium/*toxicity
Flavanones/*pharmacology
Protective Agents/*pharmacology
Testis/*pathology
Animals ; Biomarkers/metabolism ; Body Weight/drug effects ; Drinking/drug effects ; Epididymis/drug effects ; Epididymis/pathology ; Feeding Behavior/drug effects ; Gene Expression Regulation/drug effects ; Hormones/blood ; Inflammation/pathology ; Male ; Oxidation-Reduction ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Rats, Wistar ; Spermatogenesis/drug effects ; Spermatozoa/drug effects ; Spermatozoa/metabolism ; Steroids/metabolism ; Testis/drug effects ; Testis/metabolism
Czasopismo naukowe
Tytuł :
MircoRNA-143-3p regulating ARL6 is involved in the cadmium-induced inhibition of osteogenic differentiation in human bone marrow mesenchymal stem cells.
Autorzy :
Wu L; Center for Global Health, China International Cooperation Center for Environment and Human Health, School of Public Health, Nanjing Medical University, Nanjing, 211166, Jiangsu, People's Republic of China; The Key Laboratory of Modern Toxicology, Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, 211166, Jiangsu, People's Republic of China.
Song J; Food Safety and Health Research Center, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, 510515, Guangdong, People's Republic of China.
Xue J; Center for Global Health, China International Cooperation Center for Environment and Human Health, School of Public Health, Nanjing Medical University, Nanjing, 211166, Jiangsu, People's Republic of China; The Key Laboratory of Modern Toxicology, Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, 211166, Jiangsu, People's Republic of China.
Xiao T; Center for Global Health, China International Cooperation Center for Environment and Human Health, School of Public Health, Nanjing Medical University, Nanjing, 211166, Jiangsu, People's Republic of China; The Key Laboratory of Modern Toxicology, Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, 211166, Jiangsu, People's Republic of China.
Wei Q; Food Safety and Health Research Center, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, 510515, Guangdong, People's Republic of China.
Zhang Z; Department of Orthopedics, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510080, Guangdong, People's Republic of China.
Zhang Y; Food Safety and Health Research Center, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, 510515, Guangdong, People's Republic of China.
Li Z; Food Safety and Health Research Center, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, 510515, Guangdong, People's Republic of China.
Hu Y; Department of Environmental Hygiene, School of Medicine, Jinan University, Guangzhou, 510632, Guangdong, People's Republic of China.
Zhang G; Department of Environmental Hygiene, School of Medicine, Jinan University, Guangzhou, 510632, Guangdong, People's Republic of China.
Xia H; Center for Global Health, China International Cooperation Center for Environment and Human Health, School of Public Health, Nanjing Medical University, Nanjing, 211166, Jiangsu, People's Republic of China; The Key Laboratory of Modern Toxicology, Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, 211166, Jiangsu, People's Republic of China.
Li J; Center for Global Health, China International Cooperation Center for Environment and Human Health, School of Public Health, Nanjing Medical University, Nanjing, 211166, Jiangsu, People's Republic of China; The Key Laboratory of Modern Toxicology, Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, 211166, Jiangsu, People's Republic of China.
Yang X; Food Safety and Health Research Center, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, 510515, Guangdong, People's Republic of China. Electronic address: .
Liu Q; Center for Global Health, China International Cooperation Center for Environment and Human Health, School of Public Health, Nanjing Medical University, Nanjing, 211166, Jiangsu, People's Republic of China; The Key Laboratory of Modern Toxicology, Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, 211166, Jiangsu, People's Republic of China. Electronic address: .
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Źródło :
Toxicology letters [Toxicol Lett] 2020 Oct 01; Vol. 331, pp. 159-166. Date of Electronic Publication: 2020 Jun 06.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Expression Regulation*/drug effects
ADP-Ribosylation Factors/*metabolism
Cadmium/*toxicity
Cell Differentiation/*drug effects
Mesenchymal Stem Cells/*drug effects
MicroRNAs/*genetics
Osteogenesis/*drug effects
3' Untranslated Regions ; ADP-Ribosylation Factors/genetics ; Cell Culture Techniques ; Cell Differentiation/genetics ; Cell Line ; Humans ; Mesenchymal Stem Cells/cytology ; Mesenchymal Stem Cells/metabolism ; Osteogenesis/genetics ; Wnt Signaling Pathway/drug effects
Czasopismo naukowe
Tytuł :
The MyD88 inhibitor TJ-M2010-2 suppresses proliferation, migration and invasion of breast cancer cells by regulating MyD88/GSK-3β and MyD88/NF-κB signalling pathways.
Autorzy :
Liu JH; Department of Breast and Thyroid Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei, 430060, PR China.
Chen C; Department of Breast and Thyroid Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei, 430060, PR China.
Li ZY; Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Zou ZM; Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Gao DC; Department of Breast and Thyroid Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei, 430060, PR China.
Zhang X; Department of Breast and Thyroid Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei, 430060, PR China.
Kuang XW; Department of Breast and Thyroid Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei, 430060, PR China.
Sun ZH; Department of Breast and Thyroid Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei, 430060, PR China.
Zheng WJ; Department of Breast and Thyroid Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei, 430060, PR China.
Zhou P; Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. Electronic address: .
Sun SR; Department of Breast and Thyroid Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei, 430060, PR China. Electronic address: .
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Źródło :
Experimental cell research [Exp Cell Res] 2020 Sep 15; Vol. 394 (2), pp. 112157. Date of Electronic Publication: 2020 Jun 29.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Signal Transduction*/drug effects
Breast Neoplasms/*pathology
Cell Movement/*drug effects
Glycogen Synthase Kinase 3 beta/*metabolism
Myeloid Differentiation Factor 88/*antagonists & inhibitors
NF-kappa B/*metabolism
Thiazoles/*pharmacology
Animals ; Apoptosis/drug effects ; Breast Neoplasms/blood supply ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cytokines/metabolism ; Down-Regulation/drug effects ; Epithelial-Mesenchymal Transition/drug effects ; Female ; Humans ; Lipopolysaccharides/pharmacology ; Macrophages/drug effects ; Macrophages/metabolism ; Mice, Inbred BALB C ; Mice, Nude ; Myeloid Differentiation Factor 88/metabolism ; Neoplasm Invasiveness ; Neoplasm Proteins/metabolism ; Neovascularization, Pathologic/pathology ; Piperazines ; Tumor Microenvironment/drug effects ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Effects of resveratrol on autophagy and the expression of inflammasomes in a placental trophoblast oxidative stress model.
Autorzy :
Li M; Department of Traditional Chinese Medicine, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China.
Wu X; Department of Obstetrics and Gynecology, Second Affiliated Hospital, Medical School of Xi'an Jiaotong University, China.
An P; Department of Traditional Chinese Medicine, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China.
Dang H; Department of Traditional Chinese Medicine, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China. Electronic address: .
Liu Y; Department of Traditional Chinese Medicine, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China.
Liu R; Department of Traditional Chinese Medicine, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China.
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Źródło :
Life sciences [Life Sci] 2020 Sep 01; Vol. 256, pp. 117890. Date of Electronic Publication: 2020 Jun 01.
Typ publikacji :
Journal Article
MeSH Terms :
Models, Biological*
Oxidative Stress*/drug effects
Autophagy/*drug effects
Inflammasomes/*metabolism
Resveratrol/*pharmacology
Trophoblasts/*pathology
Antioxidants/pharmacology ; Apoptosis/drug effects ; Caspase 1/metabolism ; Catalase/metabolism ; Cell Line ; Cell Survival/drug effects ; Female ; Fluorescent Dyes/chemistry ; Humans ; Hydrogen Peroxide/toxicity ; Interleukin-1beta/metabolism ; L-Lactate Dehydrogenase/metabolism ; Malondialdehyde/metabolism ; Pregnancy ; Reactive Oxygen Species/metabolism ; Superoxide Dismutase/metabolism ; Trophoblasts/drug effects ; Trophoblasts/metabolism
Czasopismo naukowe
Tytuł :
Suppression of BACE1 and amyloidogenic/RAGE axis by sitagliptin ameliorates PTZ kindling-induced cognitive deficits in rats.
Autorzy :
Safar MM; Pharmacology and Toxicology Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt; Pharmacology and Biochemistry Department, Faculty of Pharmacy, The British University in Egypt, Cairo, Egypt.
Shahin NN; Biochemistry Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
Mohamed AF; Pharmacology and Toxicology Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt. Electronic address: .
Abdelkader NF; Pharmacology and Toxicology Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
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Źródło :
Chemico-biological interactions [Chem Biol Interact] 2020 Sep 01; Vol. 328, pp. 109144. Date of Electronic Publication: 2020 Jul 09.
Typ publikacji :
Journal Article
MeSH Terms :
Signal Transduction*/drug effects
Amyloid/*metabolism
Amyloid Precursor Protein Secretases/*metabolism
Aspartic Acid Endopeptidases/*metabolism
Cognition Disorders/*chemically induced
Cognition Disorders/*metabolism
Kindling, Neurologic/*drug effects
Receptor for Advanced Glycation End Products/*metabolism
Sitagliptin Phosphate/*pharmacology
Amyloid beta-Peptides/metabolism ; Animals ; Biomarkers/metabolism ; Brain-Derived Neurotrophic Factor/metabolism ; Cognition Disorders/pathology ; Glucagon-Like Peptide 1/metabolism ; Glycogen Synthase Kinase 3 beta/metabolism ; Hippocampus/drug effects ; Hippocampus/pathology ; Insulin-Like Growth Factor I/metabolism ; Male ; Matrix Metalloproteinase 9/metabolism ; Neural Inhibition/drug effects ; Neurons/drug effects ; Neurons/metabolism ; Neurons/pathology ; Neurotransmitter Agents/metabolism ; Pentylenetetrazole ; Rats, Wistar ; Seizures/chemically induced ; Seizures/metabolism ; Seizures/pathology ; Spatial Memory/drug effects ; tau Proteins/metabolism
Czasopismo naukowe

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