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Wyszukujesz frazę ""eIF-2 Kinase"" wg kryterium: Temat


Tytuł:
Endoplasmic reticulum stress and the unfolded protein response: emerging regulators in progression of traumatic brain injury.
Autorzy:
Yang Y; Department of Neurosurgery & Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, 188Shizi Street, Suzhou, 215006, Jiangsu Province, China.; Suzhou Medical College of Soochow University, Suzhou, Jiangsu Province, China.
Lu D; Department of Neurosurgery & Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, 188Shizi Street, Suzhou, 215006, Jiangsu Province, China.
Wang M; Department of Neurosurgery & Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, 188Shizi Street, Suzhou, 215006, Jiangsu Province, China.; Suzhou Medical College of Soochow University, Suzhou, Jiangsu Province, China.
Liu G; Department of Neurosurgery & Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, 188Shizi Street, Suzhou, 215006, Jiangsu Province, China.
Feng Y; Department of Neurosurgery & Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, 188Shizi Street, Suzhou, 215006, Jiangsu Province, China.; Suzhou Medical College of Soochow University, Suzhou, Jiangsu Province, China.
Ren Y; Department of Neurosurgery & Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, 188Shizi Street, Suzhou, 215006, Jiangsu Province, China.
Sun X; Department of Neurosurgery & Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, 188Shizi Street, Suzhou, 215006, Jiangsu Province, China. .
Chen Z; Department of Neurosurgery & Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, 188Shizi Street, Suzhou, 215006, Jiangsu Province, China. .
Wang Z; Department of Neurosurgery & Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, 188Shizi Street, Suzhou, 215006, Jiangsu Province, China. .
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Źródło:
Cell death & disease [Cell Death Dis] 2024 Feb 20; Vol. 15 (2), pp. 156. Date of Electronic Publication: 2024 Feb 20.
Typ publikacji:
Journal Article; Review
MeSH Terms:
eIF-2 Kinase*/genetics
eIF-2 Kinase*/metabolism
Brain Injuries, Traumatic*
Humans ; Endoplasmic Reticulum Stress ; Unfolded Protein Response ; Autophagy
Czasopismo naukowe
Tytuł:
Early Atf4 activity drives airway club and goblet cell differentiation.
Autorzy:
Barrera-Lopez JF; https://ror.org/0174shg90 Departamento de Bioquímica, Biología Molecular y Genética, Facultad de Ciencias, Universidad de Extremadura, Badajoz, Spain.
Cumplido-Laso G; https://ror.org/0174shg90 Departamento de Bioquímica, Biología Molecular y Genética, Facultad de Ciencias, Universidad de Extremadura, Badajoz, Spain.
Olivera-Gomez M; https://ror.org/0174shg90 Departamento de Bioquímica, Biología Molecular y Genética, Facultad de Ciencias, Universidad de Extremadura, Badajoz, Spain.
Garrido-Jimenez S; https://ror.org/0174shg90 Departamento de Bioquímica, Biología Molecular y Genética, Facultad de Ciencias, Universidad de Extremadura, Badajoz, Spain.
Diaz-Chamorro S; https://ror.org/0174shg90 Departamento de Bioquímica, Biología Molecular y Genética, Facultad de Ciencias, Universidad de Extremadura, Badajoz, Spain.
Mateos-Quiros CM; https://ror.org/0174shg90 Departamento de Bioquímica, Biología Molecular y Genética, Facultad de Ciencias, Universidad de Extremadura, Badajoz, Spain.
Benitez DA; https://ror.org/0174shg90 Departamento de Bioquímica, Biología Molecular y Genética, Facultad de Ciencias, Universidad de Extremadura, Badajoz, Spain.
Centeno F; https://ror.org/0174shg90 Departamento de Bioquímica, Biología Molecular y Genética, Facultad de Ciencias, Universidad de Extremadura, Badajoz, Spain.
Mulero-Navarro S; https://ror.org/0174shg90 Departamento de Bioquímica, Biología Molecular y Genética, Facultad de Ciencias, Universidad de Extremadura, Badajoz, Spain.
Roman AC; https://ror.org/0174shg90 Departamento de Bioquímica, Biología Molecular y Genética, Facultad de Ciencias, Universidad de Extremadura, Badajoz, Spain.
Carvajal-Gonzalez JM; https://ror.org/0174shg90 Departamento de Bioquímica, Biología Molecular y Genética, Facultad de Ciencias, Universidad de Extremadura, Badajoz, Spain .
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Źródło:
Life science alliance [Life Sci Alliance] 2024 Jan 04; Vol. 7 (3). Date of Electronic Publication: 2024 Jan 04 (Print Publication: 2024).
Typ publikacji:
Journal Article
MeSH Terms:
eIF-2 Kinase*/genetics
Endoplasmic Reticulum Stress*/genetics
Animals ; Mice ; Activating Transcription Factor 4/genetics ; Activating Transcription Factor 4/metabolism ; Cell Differentiation/genetics ; Respiratory System/metabolism
Czasopismo naukowe
Tytuł:
SARS-CoV-2 variant-specific differences in inhibiting the effects of the PKR-activated integrated stress response.
Autorzy:
Christ W; Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet. Stockholm, Sweden.
Klingström J; Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet. Stockholm, Sweden; Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden. Electronic address: .
Tynell J; Zoonosis Unit, Department of Virology, Medical Faculty, University of Helsinki, Helsinki, Finland; Department of Clinical Microbiology, Umeå University, Umeå, Sweden.
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Źródło:
Virus research [Virus Res] 2024 Jan 02; Vol. 339, pp. 199271. Date of Electronic Publication: 2023 Nov 28.
Typ publikacji:
Journal Article
MeSH Terms:
COVID-19*/virology
SARS-CoV-2*
Stress, Physiological*
eIF-2 Kinase*/metabolism
Humans ; Phosphorylation
SCR Organism:
SARS-CoV-2 variants
Czasopismo naukowe
Tytuł:
Pharmacologic activation of a compensatory integrated stress response kinase promotes mitochondrial remodeling in PERK-deficient cells.
Autorzy:
Perea V; Department of Molecular and Cellular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Baron KR; Department of Molecular and Cellular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Dolina V; Department of Molecular and Cellular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Aviles G; Department of Biophysics and Biochemistry and Institute for Neurodegenerative Diseases, UCSF, San Francisco, CA 94158, USA.
Kim G; Department of Molecular and Cellular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Rosarda JD; Department of Molecular and Cellular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA; Department of Anatomy, Physiology, and Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.
Guo X; Department of Biophysics and Biochemistry and Institute for Neurodegenerative Diseases, UCSF, San Francisco, CA 94158, USA; Department of Genetics and Genome Sciences, University of Connecticut Health, Farmington, CT 06030, USA.
Kampmann M; Department of Biophysics and Biochemistry and Institute for Neurodegenerative Diseases, UCSF, San Francisco, CA 94158, USA.
Wiseman RL; Department of Molecular and Cellular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA. Electronic address: .
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Źródło:
Cell chemical biology [Cell Chem Biol] 2023 Dec 21; Vol. 30 (12), pp. 1571-1584.e5. Date of Electronic Publication: 2023 Nov 02.
Typ publikacji:
Journal Article
MeSH Terms:
eIF-2 Kinase*/genetics
eIF-2 Kinase*/metabolism
Mitochondrial Diseases*/metabolism
Mitochondria/metabolism ; Phosphorylation ; Protein Processing, Post-Translational ; Signal Transduction ; Animals ; Mice
Czasopismo naukowe
Tytuł:
Involvement of Protein Kinase R in Double-Stranded RNA-Induced Proteasomal Degradation of Hypoxia Inducible Factor-1α.
Autorzy:
Hotani T; Laboratory of Biochemistry and Molecular Biology, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Nakagawa K; Laboratory of Biochemistry and Molecular Biology, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Tsukamoto T; Laboratory of Biochemistry and Molecular Biology, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Mizuguchi H; Laboratory of Biochemistry and Molecular Biology, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka, 565-0871, Japan.; The Center for Advanced Medical Engineering and Informatics, Osaka University, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.; Laboratory of Functional Organoid for Drug Discovery, Center for Drug Discovery Resources Research, National Institute of Biomedical Innovation, Health and Nutrition, 7-6-8 Saito, Asagi, Ibaraki, Osaka, 567-0085, Japan.; Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University, Osaka, 565-0871, Japan.; Center for Infectious Disease Education and Research (CiDER), Osaka University, Osaka, 565-0871, Japan.
Sakurai F; Laboratory of Biochemistry and Molecular Biology, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka, 565-0871, Japan. .
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Źródło:
Inflammation [Inflammation] 2023 Dec; Vol. 46 (6), pp. 2332-2342. Date of Electronic Publication: 2023 Aug 24.
Typ publikacji:
Journal Article
MeSH Terms:
eIF-2 Kinase*/genetics
eIF-2 Kinase*/metabolism
Hypoxia-Inducible Factor 1, alpha Subunit*/genetics
Hypoxia-Inducible Factor 1, alpha Subunit*/metabolism
RNA, Double-Stranded*/metabolism
Animals ; Humans ; Cell Hypoxia ; Down-Regulation ; Hypoxia ; Ubiquitination
Czasopismo naukowe
Tytuł:
The PERK Branch of the Unfolded Protein Response Safeguards Protein Homeostasis and Mesendoderm Specification of Human Pluripotent Stem Cells.
Autorzy:
Liu F; Advanced Medical Technology Center, Zhongshan School of Medicine and the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510080, P. R. China.; Key Laboratory for Stem Cells and Tissue Engineering, Sun Yat-Sen University, Ministry of Education, Guangzhou, 510080, P. R. China.; Department of Clinical Laboratory, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, P. R. China.
Liu Z; Advanced Medical Technology Center, Zhongshan School of Medicine and the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510080, P. R. China.; Key Laboratory for Stem Cells and Tissue Engineering, Sun Yat-Sen University, Ministry of Education, Guangzhou, 510080, P. R. China.
Cheng W; Prenatal Diagnosis Center, Department of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, P. R. China.; Department of Medical Informatics, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, 510080, P. R. China.
Zhao Q; Advanced Medical Technology Center, Zhongshan School of Medicine and the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510080, P. R. China.; Key Laboratory for Stem Cells and Tissue Engineering, Sun Yat-Sen University, Ministry of Education, Guangzhou, 510080, P. R. China.
Zhang X; Advanced Medical Technology Center, Zhongshan School of Medicine and the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510080, P. R. China.; Key Laboratory for Stem Cells and Tissue Engineering, Sun Yat-Sen University, Ministry of Education, Guangzhou, 510080, P. R. China.
Zhang H; Advanced Medical Technology Center, Zhongshan School of Medicine and the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510080, P. R. China.; Key Laboratory for Stem Cells and Tissue Engineering, Sun Yat-Sen University, Ministry of Education, Guangzhou, 510080, P. R. China.
Yu M; Advanced Medical Technology Center, Zhongshan School of Medicine and the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510080, P. R. China.; Key Laboratory for Stem Cells and Tissue Engineering, Sun Yat-Sen University, Ministry of Education, Guangzhou, 510080, P. R. China.
Xu H; Advanced Medical Technology Center, Zhongshan School of Medicine and the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510080, P. R. China.; Key Laboratory for Stem Cells and Tissue Engineering, Sun Yat-Sen University, Ministry of Education, Guangzhou, 510080, P. R. China.
Gao Y; Advanced Medical Technology Center, Zhongshan School of Medicine and the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510080, P. R. China.; Key Laboratory for Stem Cells and Tissue Engineering, Sun Yat-Sen University, Ministry of Education, Guangzhou, 510080, P. R. China.
Jiang Q; Advanced Medical Technology Center, Zhongshan School of Medicine and the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510080, P. R. China.; Key Laboratory for Stem Cells and Tissue Engineering, Sun Yat-Sen University, Ministry of Education, Guangzhou, 510080, P. R. China.
Shi G; Guangzhou Municipal Key Laboratory of Mechanistic and Translational Obesity Research, Guangdong Provincial Key Laboratory of Diabetology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangdong, 510080, P. R. China.
Wang L; National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, P. R. China.; College of Life Sciences, University of Chinese Academy of Sciences, Beijing, 100049, P. R. China.
Gu S; Advanced Medical Technology Center, Zhongshan School of Medicine and the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510080, P. R. China.; Key Laboratory for Stem Cells and Tissue Engineering, Sun Yat-Sen University, Ministry of Education, Guangzhou, 510080, P. R. China.
Wang J; School of Health and Life Sciences, University of Health and Rehabilitation Sciences, Shandong, 266071, China.
Cao N; Advanced Medical Technology Center, Zhongshan School of Medicine and the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510080, P. R. China.; Key Laboratory for Stem Cells and Tissue Engineering, Sun Yat-Sen University, Ministry of Education, Guangzhou, 510080, P. R. China.
Chen Z; Advanced Medical Technology Center, Zhongshan School of Medicine and the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510080, P. R. China.; Key Laboratory for Stem Cells and Tissue Engineering, Sun Yat-Sen University, Ministry of Education, Guangzhou, 510080, P. R. China.
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Źródło:
Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2023 Dec; Vol. 10 (35), pp. e2303799. Date of Electronic Publication: 2023 Oct 27.
Typ publikacji:
Journal Article
MeSH Terms:
eIF-2 Kinase*/genetics
eIF-2 Kinase*/metabolism
Pluripotent Stem Cells*/metabolism
Humans ; Proteome/metabolism ; Proteostasis ; Unfolded Protein Response
Czasopismo naukowe
Tytuł:
PKR-mediated stress response enhances dengue and Zika virus replication.
Autorzy:
Ricciardi-Jorge T; Departamento de Microbiologia, Imunologia e Parasitologia, Universidade Federal de Santa Catarina (UFSC) , Florianópolis, Brazil.; The Pirbright Institute , Woking, United Kingdom.
da Rocha EL; Departamento de Microbiologia, Imunologia e Parasitologia, Universidade Federal de Santa Catarina (UFSC) , Florianópolis, Brazil.
Gonzalez-Kozlova E; Departamento de Microbiologia, Imunologia e Parasitologia, Universidade Federal de Santa Catarina (UFSC) , Florianópolis, Brazil.; Icahn School of Medicine , New York, USA.
Rodrigues-Luiz GF; Departamento de Microbiologia, Imunologia e Parasitologia, Universidade Federal de Santa Catarina (UFSC) , Florianópolis, Brazil.
Ferguson BJ; Department of Pathology, University of Cambridge , Cambridge, United Kingdom.
Sweeney T; The Pirbright Institute , Woking, United Kingdom.
Irigoyen N; Department of Pathology, University of Cambridge , Cambridge, United Kingdom.
Mansur DS; Departamento de Microbiologia, Imunologia e Parasitologia, Universidade Federal de Santa Catarina (UFSC) , Florianópolis, Brazil.
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Źródło:
MBio [mBio] 2023 Oct 31; Vol. 14 (5), pp. e0093423. Date of Electronic Publication: 2023 Sep 21.
Typ publikacji:
Journal Article
MeSH Terms:
Dengue Virus*/physiology
eIF-2 Kinase*/genetics
eIF-2 Kinase*/metabolism
Stress, Physiological*/genetics
Stress, Physiological*/immunology
Virus Replication*/genetics
Virus Replication*/immunology
Zika Virus*/physiology
Animals ; Humans ; A549 Cells ; Chlorocebus aethiops ; Dengue/immunology ; Dengue/virology ; Eukaryotic Initiation Factor-2/metabolism ; Gene Deletion ; Protein Biosynthesis/genetics ; Protein Biosynthesis/immunology ; Vero Cells ; Zika Virus Infection/immunology ; Zika Virus Infection/virology ; RNA, Double-Stranded/metabolism
Czasopismo naukowe
Tytuł:
Short-term activation of PERK alleviates the progression of experimental non-alcoholic steatohepatitis.
Autorzy:
Fu W; State Key Laboratory of Genetic Engineering and School of Life Sciences, Fudan University, Shanghai, China; Henan Key Laboratory of Rare Diseases, Endocrinology and Metabolism Center, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, China.
Liu C; State Key Laboratory of Genetic Engineering and School of Life Sciences, Fudan University, Shanghai, China.
Li J; State Key Laboratory of Genetic Engineering and School of Life Sciences, Fudan University, Shanghai, China. Electronic address: li_jin_.
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Źródło:
Journal of hepatology [J Hepatol] 2023 Dec; Vol. 79 (6), pp. e234-e236. Date of Electronic Publication: 2023 Jun 09.
Typ publikacji:
Letter; Research Support, Non-U.S. Gov't; Comment
MeSH Terms:
Non-alcoholic Fatty Liver Disease*
eIF-2 Kinase*/metabolism
Liver ; Animals
Raport
Tytuł:
Mitochondrial DNA breaks activate an integrated stress response to reestablish homeostasis.
Autorzy:
Fu Y; Skirball Institute of Biomolecular Medicine, Cell Biology Department, NYU School of Medicine, New York, NY 10016, USA; Molecular Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Sacco O; Molecular Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
DeBitetto E; Molecular Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Kanshin E; Proteomics Laboratory, NYU School of Medicine, New York, NY 10016, USA; Biochemistry and Molecular Pharmacology, NYU School of Medicine, New York, NY 10016, USA.
Ueberheide B; Proteomics Laboratory, NYU School of Medicine, New York, NY 10016, USA; Biochemistry and Molecular Pharmacology, NYU School of Medicine, New York, NY 10016, USA; Department of Neurology, NYU School of Medicine, New York, NY 10016, USA; Perlmutter Cancer Center, NYU School of Medicine, New York, NY 10016, USA.
Sfeir A; Molecular Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address: .
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Źródło:
Molecular cell [Mol Cell] 2023 Oct 19; Vol. 83 (20), pp. 3740-3753.e9. Date of Electronic Publication: 2023 Oct 12.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Mitochondria*/genetics
Mitochondria*/metabolism
eIF-2 Kinase*/metabolism
Humans ; Cytoplasm/metabolism ; Phosphorylation ; DNA, Mitochondrial/genetics ; DNA, Mitochondrial/metabolism ; Eukaryotic Initiation Factor-2/metabolism ; ATPases Associated with Diverse Cellular Activities/metabolism ; Membrane Proteins/metabolism ; Mitochondrial Proteins/genetics ; Mitochondrial Proteins/metabolism
Czasopismo naukowe
Tytuł:
Astrocytic deletion of protein kinase R-like ER kinase (PERK) does not affect learning and memory in aged mice but worsens outcome from experimental stroke.
Autorzy:
Lahiri A; Department of Microbiology, Immunology and Cell Biology, West Virginia University, Morgantown, West Virginia, USA.
Walton JC; Department of Neuroscience, West Virginia University, Morgantown, West Virginia, USA.
Zhang N; Department of Neuroscience, West Virginia University, Morgantown, West Virginia, USA.
Billington N; Department of Biochemistry, West Virginia University, Morgantown, West Virginia, USA.
DeVries AC; Department of Neuroscience, West Virginia University, Morgantown, West Virginia, USA.; Rockefeller Neuroscience Institute, West Virginia University, Morgantown, West Virginia, USA.; Department of Medicine, Division of Hematology and Oncology, West Virginia University, Morgantown, West Virginia, USA.; WVU Cancer Institute, Morgantown, West Virginia, USA.; West Virginia Clinical and Translational Science Institute, West Virginia University, Morgantown, West Virginia, USA.
Meares GP; Department of Microbiology, Immunology and Cell Biology, West Virginia University, Morgantown, West Virginia, USA.; Department of Neuroscience, West Virginia University, Morgantown, West Virginia, USA.; Rockefeller Neuroscience Institute, West Virginia University, Morgantown, West Virginia, USA.
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Źródło:
Journal of neuroscience research [J Neurosci Res] 2023 Oct; Vol. 101 (10), pp. 1586-1610. Date of Electronic Publication: 2023 Jun 14.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Astrocytes*
Learning*
Stroke*
eIF-2 Kinase*/metabolism
Animals ; Female ; Male ; Mice ; Endoplasmic Reticulum ; Protein Kinases
Czasopismo naukowe
Tytuł:
ER Stress Decreases Gene Expression Of Transmembrane Protein 117 Via Activation of PKR-like ER Kinase.
Autorzy:
Maruyama R; Graduate School of Bionics, Tokyo University of Technology, 1401-1 Katakura-machi, Hachioji, Tokyo, 192-0982, Japan. .; Department of Life Science, Rikkyo University, 3-34-1 Nishi-Ikebukuro, Toshima-ku, Tokyo, 171-8501, Japan. .
Sugiyama T; Graduate School of Bionics, Tokyo University of Technology, 1401-1 Katakura-machi, Hachioji, Tokyo, 192-0982, Japan.
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Źródło:
Cell biochemistry and biophysics [Cell Biochem Biophys] 2023 Sep; Vol. 81 (3), pp. 459-468. Date of Electronic Publication: 2023 Jul 08.
Typ publikacji:
Journal Article
MeSH Terms:
eIF-2 Kinase*/genetics
eIF-2 Kinase*/metabolism
Endoplasmic Reticulum Stress*
Unfolded Protein Response ; Endoplasmic Reticulum/metabolism ; Gene Expression
Czasopismo naukowe
Tytuł:
PERK signaling promotes mitochondrial elongation by remodeling membrane phosphatidic acid.
Autorzy:
Perea V; Department of Molecular Medicine, Scripps Research, La Jolla, CA, USA.
Cole C; Department of Chemistry, Scripps Research, La Jolla, CA, USA.
Lebeau J; Department of Molecular Medicine, Scripps Research, La Jolla, CA, USA.
Dolina V; Department of Molecular Medicine, Scripps Research, La Jolla, CA, USA.
Baron KR; Department of Molecular Medicine, Scripps Research, La Jolla, CA, USA.
Madhavan A; Department of Molecular Medicine, Scripps Research, La Jolla, CA, USA.
Kelly JW; Department of Chemistry, Scripps Research, La Jolla, CA, USA.; Skaggs Institute for Chemical Biology, Scripps Research, La Jolla, CA, USA.
Grotjahn DA; Department of Integrative, Structural, and Computational Biology, Scripps Research, La Jolla, CA, USA.
Wiseman RL; Department of Molecular Medicine, Scripps Research, La Jolla, CA, USA.
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Źródło:
The EMBO journal [EMBO J] 2023 Aug 01; Vol. 42 (15), pp. e113908. Date of Electronic Publication: 2023 Jun 12.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, Non-U.S. Gov't
MeSH Terms:
eIF-2 Kinase*/genetics
eIF-2 Kinase*/metabolism
Unfolded Protein Response*
Endoplasmic Reticulum Stress ; Mitochondria/metabolism ; Signal Transduction
Czasopismo naukowe
Tytuł:
The role of protein kinase R in placental inflammation, mtUPR and apoptosis.
Autorzy:
Kolac UK; Department of Medical Biology, Faculty of Medicine, Aydin Adnan Menderes University, Aydin, Turkey.
Donmez Yalcin G; Department of Medical Biology, Faculty of Medicine, Aydin Adnan Menderes University, Aydin, Turkey.
Karayel R; Department of Medical Biology, Faculty of Medicine, Aydin Adnan Menderes University, Aydin, Turkey.
Yalcin A; Department of Medical Biology, Faculty of Medicine, Aydin Adnan Menderes University, Aydin, Turkey. Electronic address: .
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Źródło:
Placenta [Placenta] 2023 Aug; Vol. 139, pp. 200-211. Date of Electronic Publication: 2023 Jul 11.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Apoptosis*
eIF-2 Kinase*/genetics
eIF-2 Kinase*/metabolism
Inflammation*/metabolism
Placenta*/physiopathology
Unfolded Protein Response*
Female ; Humans ; Pregnancy ; Lipopolysaccharides ; Reactive Oxygen Species/metabolism ; RNA, Double-Stranded/metabolism ; Poly I-C/metabolism
Czasopismo naukowe
Tytuł:
Double-stranded RNA-dependent protein kinase (PKR) in antiviral defence in fish and mammals.
Autorzy:
Chaumont L; Université Paris-Saclay, INRAE, UVSQ, VIM, Jouy-en-Josas, 78350, France.
Collet B; Université Paris-Saclay, INRAE, UVSQ, VIM, Jouy-en-Josas, 78350, France.
Boudinot P; Université Paris-Saclay, INRAE, UVSQ, VIM, Jouy-en-Josas, 78350, France. Electronic address: .
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Źródło:
Developmental and comparative immunology [Dev Comp Immunol] 2023 Aug; Vol. 145, pp. 104732. Date of Electronic Publication: 2023 May 10.
Typ publikacji:
Review; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antiviral Agents*
eIF-2 Kinase*/genetics
eIF-2 Kinase*/metabolism
Animals ; Fishes/genetics ; Fish Proteins/genetics ; Fish Proteins/metabolism ; Immunity, Innate ; RNA, Double-Stranded ; Phosphorylation ; Eukaryotic Initiation Factor-2/genetics ; Eukaryotic Initiation Factor-2/metabolism ; Mammals/genetics
Czasopismo naukowe
Tytuł:
PERK inhibition in hearts: angel or devil?
Autorzy:
Men L; Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, PR China.
Lin L; Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, PR China; Key Laboratory of Vascular Aging, Ministry of Education, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, PR China. Electronic address: .
Guo J; Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, PR China. Electronic address: .
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Źródło:
Trends in molecular medicine [Trends Mol Med] 2023 Aug; Vol. 29 (8), pp. 581-582. Date of Electronic Publication: 2023 Jun 01.
Typ publikacji:
Letter
MeSH Terms:
Unfolded Protein Response*
eIF-2 Kinase*/genetics
eIF-2 Kinase*/metabolism
Humans ; Phosphorylation
Opinia redakcyjna
Tytuł:
Chronic obstructive pulmonary disease and emerging ER stress-related therapeutic targets.
Autorzy:
Yeap JW; School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800, Pulau Pinang, Malaysia.
Ali IAH; Respiratory Department, Penang General Hospital, Jalan Residensi, 10990, Pulau Pinang, Malaysia.
Ibrahim B; Department of Clinical Pharmacy & Pharmacy Practice, Faculty of Pharmacy, Universiti Malaya, 50603, Kuala Lumpur, Malaysia.
Tan ML; School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800, Pulau Pinang, Malaysia; Centre For Global Sustainability Studies (CGSS), Universiti Sains Malaysia, 11800, Pulau Pinang, Malaysia. Electronic address: .
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Źródło:
Pulmonary pharmacology & therapeutics [Pulm Pharmacol Ther] 2023 Aug; Vol. 81, pp. 102218. Date of Electronic Publication: 2023 May 16.
Typ publikacji:
Systematic Review; Journal Article; Review; Research Support, Non-U.S. Gov't
MeSH Terms:
eIF-2 Kinase*
Pulmonary Disease, Chronic Obstructive*/drug therapy
Humans ; Endoplasmic Reticulum Stress/physiology ; Unfolded Protein Response
Czasopismo naukowe
Tytuł:
PERK Inhibition Suppresses Neovascularization and Protects Neurons During Ischemia-Induced Retinopathy.
Autorzy:
Shi S; Department of Ophthalmology & Visual Sciences, University of Texas Medical Branch, Galveston, Texas, United States.
Ding C; Department of Ophthalmology & Visual Sciences, University of Texas Medical Branch, Galveston, Texas, United States.
Zhu S; Department of Ophthalmology & Visual Sciences, University of Texas Medical Branch, Galveston, Texas, United States.
Xia F; Department of Ophthalmology & Visual Sciences, University of Texas Medical Branch, Galveston, Texas, United States.
Buscho SE; Department of Ophthalmology & Visual Sciences, University of Texas Medical Branch, Galveston, Texas, United States.
Li S; Department of Ophthalmology & Visual Sciences, University of Texas Medical Branch, Galveston, Texas, United States.
Motamedi M; Department of Ophthalmology & Visual Sciences, University of Texas Medical Branch, Galveston, Texas, United States.
Liu H; Department of Ophthalmology & Visual Sciences, University of Texas Medical Branch, Galveston, Texas, United States.
Zhang W; Department of Ophthalmology & Visual Sciences, University of Texas Medical Branch, Galveston, Texas, United States.; Departments of Neurobiology, University of Texas Medical Branch, Galveston, Texas, United States.
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Źródło:
Investigative ophthalmology & visual science [Invest Ophthalmol Vis Sci] 2023 Aug 01; Vol. 64 (11), pp. 17.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Retinal Diseases*/etiology
Retinal Diseases*/prevention & control
Retinal Neovascularization*/prevention & control
Retinal Neovascularization*/metabolism
Retinopathy of Prematurity*/metabolism
eIF-2 Kinase*/metabolism
Animals ; Mice ; Animals, Newborn ; Disease Models, Animal ; Ischemia/metabolism ; Mice, Inbred C57BL ; Neovascularization, Pathologic/metabolism ; Oxygen/metabolism ; Retina ; Retinal Ganglion Cells/metabolism
Czasopismo naukowe
Tytuł:
Important roles of heme-regulated eIF-2α kinase in cadmium-induced glycolysis under acute exposure.
Autorzy:
Wang Q; Biomedical Sciences College & Shandong Medicinal Biotechnology Centre, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, 250117, Shandong, China.; School of Public Health, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, 250117, Shandong, China.
Ma W; School of Public Health, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, 250117, Shandong, China.; Medical Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, 250117, Shandong, China.
Zhang S; Biomedical Sciences College & Shandong Medicinal Biotechnology Centre, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, 250117, Shandong, China. .; School of Public Health, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, 250117, Shandong, China. .
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Źródło:
Environmental science and pollution research international [Environ Sci Pollut Res Int] 2023 Aug; Vol. 30 (38), pp. 88444-88449. Date of Electronic Publication: 2023 Jul 12.
Typ publikacji:
Journal Article
MeSH Terms:
eIF-2 Kinase*/metabolism
Anemia*
Humans ; Animals ; Mice ; Heme/metabolism ; Cadmium/toxicity ; Mice, Knockout
Czasopismo naukowe
Tytuł:
Ubiquitin-like protein 5 is a novel player in the UPR-PERK arm and ER stress-induced cell death.
Autorzy:
Wang W; Department of Biochemistry & Molecular Biology, School of Medicine, Virginia Commonwealth University, Richmond, Virginia, USA.
Hawkridge AM; Department of Pharmaceutics, School of Pharmacy, Virginia Commonwealth University, Richmond, Virginia, USA.
Ma Y; Department of Biochemistry & Molecular Biology, School of Medicine, Virginia Commonwealth University, Richmond, Virginia, USA.
Zhang B; Department of Biostatistics, School of Medicine, Virginia Commonwealth University, Richmond, Virginia, USA.
Mangrum JB; Department of Pharmaceutics, School of Pharmacy, Virginia Commonwealth University, Richmond, Virginia, USA.
Hassan ZH; Department of Pharmaceutics, School of Pharmacy, Virginia Commonwealth University, Richmond, Virginia, USA.
He T; Department of Biochemistry & Molecular Biology, School of Medicine, Virginia Commonwealth University, Richmond, Virginia, USA.
Blat S; Department of Biochemistry & Molecular Biology, School of Medicine, Virginia Commonwealth University, Richmond, Virginia, USA.
Guo C; Department of Human & Molecular Genetics, School of Medicine, Virginia Commonwealth University, Richmond, Virginia, USA.
Zhou H; Department of Microbiology & Immunology, School of Medicine, Virginia Commonwealth University, Richmond, Virginia, USA; Hunter Holmes McGuire VA Medical Center, Richmond, Virginia, USA.
Liu J; Department of Biostatistics, School of Medicine, Virginia Commonwealth University, Richmond, Virginia, USA.
Wang XY; Department of Human & Molecular Genetics, School of Medicine, Virginia Commonwealth University, Richmond, Virginia, USA; Hunter Holmes McGuire VA Medical Center, Richmond, Virginia, USA.
Fang X; Department of Biochemistry & Molecular Biology, School of Medicine, Virginia Commonwealth University, Richmond, Virginia, USA. Electronic address: .
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Źródło:
The Journal of biological chemistry [J Biol Chem] 2023 Jul; Vol. 299 (7), pp. 104915. Date of Electronic Publication: 2023 Jun 12.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Cell Death*
eIF-2 Kinase*/metabolism
Endoplasmic Reticulum Stress*
Ubiquitins*/genetics
Ubiquitins*/metabolism
Animals ; Mice ; Apoptosis ; Unfolded Protein Response
Czasopismo naukowe
Tytuł:
The fifth element: a novel eIF2α kinase in microglia.
Autorzy:
Ruggieri A; Department of Infectious Diseases, Molecular Virology, Center for Integrative Infectious Diseases Research, Medical Faculty Heidelberg, Heidelberg University, Heidelberg, Germany.
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Źródło:
EMBO reports [EMBO Rep] 2023 May 04; Vol. 24 (5), pp. e57231. Date of Electronic Publication: 2023 Apr 06.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
eIF-2 Kinase*/genetics
eIF-2 Kinase*/metabolism
Microglia*/metabolism
Phosphorylation ; Eukaryotic Initiation Factor-2/genetics ; Eukaryotic Initiation Factor-2/metabolism ; Oxidative Stress
Czasopismo naukowe

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