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Tytuł :
Inducible expression of a disease-associated ELANE mutation impairs granulocytic differentiation, without eliciting an unfolded protein response.
Autorzy :
Garg B; Department of Pediatrics, Cleveland Clinic, Cleveland, Ohio 44195.; Department of Cancer Biology, Cleveland Clinic, Cleveland, Ohio 44195.; Department of Translational Hematology and Oncology Research, Cleveland Clinic, Cleveland, Ohio 44195.
Mehta HM; Department of Pediatrics, Cleveland Clinic, Cleveland, Ohio 44195.; Department of Cancer Biology, Cleveland Clinic, Cleveland, Ohio 44195.; Department of Translational Hematology and Oncology Research, Cleveland Clinic, Cleveland, Ohio 44195.
Wang B; Department of Pediatrics, Cleveland Clinic, Cleveland, Ohio 44195.; Department of Cancer Biology, Cleveland Clinic, Cleveland, Ohio 44195.; Department of Translational Hematology and Oncology Research, Cleveland Clinic, Cleveland, Ohio 44195.
Kamel R; Department of Pediatrics, Virginia Commonwealth University School of Medicine, Richmond, Virginia 23298.
Horwitz MS; Department of Pathology, University of Washington School of Medicine, Seattle, Washington 98195.
Corey SJ; Department of Pediatrics, Cleveland Clinic, Cleveland, Ohio 44195 .; Department of Cancer Biology, Cleveland Clinic, Cleveland, Ohio 44195.; Department of Translational Hematology and Oncology Research, Cleveland Clinic, Cleveland, Ohio 44195.
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2020 May 22; Vol. 295 (21), pp. 7492-7500. Date of Electronic Publication: 2020 Apr 16.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Congenital Bone Marrow Failure Syndromes*/enzymology
Congenital Bone Marrow Failure Syndromes*/genetics
Gene Expression Regulation, Enzymologic*
Leukocyte Elastase*/biosynthesis
Leukocyte Elastase*/genetics
Mutation, Missense*
Unfolded Protein Response*
Granulocytes/*enzymology
Neutropenia/*congenital
Amino Acid Substitution ; Animals ; Apoptosis ; Cell Line, Tumor ; Endoplasmic Reticulum Stress ; Humans ; Mice ; Neutropenia/enzymology ; Neutropenia/genetics ; Transcription Factors/genetics ; Transcription Factors/metabolism
SCR Disease Name :
Neutropenia, Severe Congenital, Autosomal Recessive 3
Czasopismo naukowe
Tytuł :
Characterization of intra- and inter-species hybrid tetramers of pyruvate carboxylase: Biotin and the BCCP domain play a crucial role in determination of the kinetics and thermodynamics of catalysis.
Autorzy :
Rattanapornsompong K; Department of Biochemistry, Faculty of Science, Mahidol University, Bangkok, 10400, Thailand.
Jitrapakdee S; Department of Biochemistry, Faculty of Science, Mahidol University, Bangkok, 10400, Thailand. Electronic address: .
Attwood PV; School of Molecular Sciences, The University of Western Australia, 35 Stirling Highway, Perth, WA, 6009, Australia. Electronic address: .
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Źródło :
Archives of biochemistry and biophysics [Arch Biochem Biophys] 2020 Nov 30; Vol. 695, pp. 108630. Date of Electronic Publication: 2020 Oct 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Aspergillus nidulans*/enzymology
Aspergillus nidulans*/genetics
Chickens*
Rhizobium etli*/enzymology
Rhizobium etli*/genetics
Avian Proteins/*chemistry
Bacterial Proteins/*chemistry
Biotin/*chemistry
Fungal Proteins/*chemistry
Liver/*enzymology
Pyruvate Carboxylase/*chemistry
Animals ; Avian Proteins/genetics ; Avian Proteins/metabolism ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Biotin/genetics ; Biotin/metabolism ; Catalysis ; Fungal Proteins/genetics ; Fungal Proteins/metabolism ; Protein Domains ; Protein Structure, Quaternary ; Pyruvate Carboxylase/genetics ; Pyruvate Carboxylase/metabolism ; Recombinant Fusion Proteins/chemistry ; Recombinant Fusion Proteins/genetics ; Recombinant Fusion Proteins/metabolism
Czasopismo naukowe
Tytuł :
QSAR Modeling of SARS-CoV M Inhibitors Identifies Sufugolix, Cenicriviroc, Proglumetacin, and other Drugs as Candidates for Repurposing against SARS-CoV-2.
Autorzy :
Alves VM; Office of Data Science, National Toxicology Program, NIEHS, Morrisville, NC, 27560, USA.
Bobrowski T; Laboratory for Molecular Modeling, Division of Chemical Biology and Medicinal Chemistry, Beard Hall, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, 27599, USA.
Melo-Filho CC; Laboratory for Molecular Modeling, Division of Chemical Biology and Medicinal Chemistry, Beard Hall, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, 27599, USA.
Korn D; Laboratory for Molecular Modeling, Division of Chemical Biology and Medicinal Chemistry, Beard Hall, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, 27599, USA.; Department of Computer Science, University of North Carolina, Chapel Hill, NC, 27599, USA.
Auerbach S; Toxinformatics Group, National Toxicology Program, NIEHS, Morrisville, NC, 27560, USA.
Schmitt C; Office of Data Science, National Toxicology Program, NIEHS, Morrisville, NC, 27560, USA.
Muratov EN; Laboratory for Molecular Modeling, Division of Chemical Biology and Medicinal Chemistry, Beard Hall, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, 27599, USA.; Department of Pharmaceutical Sciences, Federal University of Paraiba, Joao Pessoa, PB, Brazil.
Tropsha A; Laboratory for Molecular Modeling, Division of Chemical Biology and Medicinal Chemistry, Beard Hall, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, 27599, USA.
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Źródło :
Molecular informatics [Mol Inform] 2021 Jan; Vol. 40 (1), pp. e2000113. Date of Electronic Publication: 2020 Aug 24.
Typ publikacji :
Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural
MeSH Terms :
Antiviral Agents*/chemistry
Antiviral Agents*/therapeutic use
COVID-19*/drug therapy
COVID-19*/enzymology
Coronavirus 3C Proteases*/antagonists & inhibitors
Coronavirus 3C Proteases*/chemistry
Drug Repositioning*
Molecular Docking Simulation*
Protease Inhibitors*/chemistry
Protease Inhibitors*/therapeutic use
Imidazoles/*chemistry
Indoleacetic Acids/*chemistry
SARS-CoV-2/*enzymology
Sulfoxides/*chemistry
Catalytic Domain ; Humans ; Imidazoles/therapeutic use ; Indoleacetic Acids/therapeutic use ; Quantitative Structure-Activity Relationship ; Sulfoxides/therapeutic use
Czasopismo naukowe
Tytuł :
High cell-density fermentation, expression and purification of bacteriophage lysin TSPphg, a thermostable antimicrobial protein from extremophilic Thermus bacteriophage TSP4.
Autorzy :
Wang F; Faculty of Life Science and Technology, Kunming University of Science and Technology, 727 South Jingming Road, Chenggong District, Kunming, Yunnan Province, 650500, China.
Zhang G; Faculty of Life Science and Technology, Kunming University of Science and Technology, 727 South Jingming Road, Chenggong District, Kunming, Yunnan Province, 650500, China.
Peng J; Faculty of Life Science and Technology, Kunming University of Science and Technology, 727 South Jingming Road, Chenggong District, Kunming, Yunnan Province, 650500, China.
Ji X; Faculty of Life Science and Technology, Kunming University of Science and Technology, 727 South Jingming Road, Chenggong District, Kunming, Yunnan Province, 650500, China.
Hai J; Faculty of Life Science and Technology, Kunming University of Science and Technology, 727 South Jingming Road, Chenggong District, Kunming, Yunnan Province, 650500, China.
Deng X; Faculty of Life Science and Technology, Kunming University of Science and Technology, 727 South Jingming Road, Chenggong District, Kunming, Yunnan Province, 650500, China.
Lin L; Faculty of Life Science and Technology, Kunming University of Science and Technology, 727 South Jingming Road, Chenggong District, Kunming, Yunnan Province, 650500, China; Engineering Research Center for Replacement Technology of Feed Antibiotics of Yunnan College, 727 South Jingming Road, Chenggong District, Kunming, Yunnan Province, 650500, China. Electronic address: .
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Źródło :
Protein expression and purification [Protein Expr Purif] 2020 Oct; Vol. 174, pp. 105676. Date of Electronic Publication: 2020 May 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Anti-Infective Agents*/chemistry
Anti-Infective Agents*/isolation & purification
Anti-Infective Agents*/pharmacology
Bacteriophages*/enzymology
Bacteriophages*/genetics
Endopeptidases*/biosynthesis
Endopeptidases*/genetics
Endopeptidases*/isolation & purification
Endopeptidases*/pharmacology
Siphoviridae*/enzymology
Siphoviridae*/genetics
Viral Proteins*/biosynthesis
Viral Proteins*/genetics
Viral Proteins*/isolation & purification
Viral Proteins*/pharmacology
Thermus/*virology
Escherichia coli/enzymology ; Escherichia coli/genetics ; Recombinant Proteins/biosynthesis ; Recombinant Proteins/genetics ; Recombinant Proteins/isolation & purification ; Recombinant Proteins/pharmacology
Czasopismo naukowe
Tytuł :
Structure of the ER membrane complex, a transmembrane-domain insertase.
Autorzy :
Bai L; Structural Biology Program, Van Andel Institute, Grand Rapids, MI, USA. .
You Q; Structural Biology Program, Van Andel Institute, Grand Rapids, MI, USA.
Feng X; Structural Biology Program, Van Andel Institute, Grand Rapids, MI, USA.
Kovach A; Structural Biology Program, Van Andel Institute, Grand Rapids, MI, USA.
Li H; Structural Biology Program, Van Andel Institute, Grand Rapids, MI, USA. .
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Źródło :
Nature [Nature] 2020 Aug; Vol. 584 (7821), pp. 475-478. Date of Electronic Publication: 2020 Jun 03.
Typ publikacji :
Journal Article
MeSH Terms :
Cryoelectron Microscopy*
Saccharomyces cerevisiae*/chemistry
Saccharomyces cerevisiae*/enzymology
Saccharomyces cerevisiae*/genetics
Saccharomyces cerevisiae*/ultrastructure
Endoplasmic Reticulum/*enzymology
Intracellular Membranes/*enzymology
Multiprotein Complexes/*chemistry
Multiprotein Complexes/*ultrastructure
Saccharomyces cerevisiae Proteins/*chemistry
Saccharomyces cerevisiae Proteins/*ultrastructure
Binding Sites ; Endoplasmic Reticulum/chemistry ; Endoplasmic Reticulum/ultrastructure ; Evolution, Molecular ; Hydrophobic and Hydrophilic Interactions ; Intracellular Membranes/chemistry ; Intracellular Membranes/ultrastructure ; Models, Molecular ; Multiprotein Complexes/genetics ; Multiprotein Complexes/metabolism ; Mutation ; Protein Domains ; Protein Subunits/chemistry ; Protein Subunits/genetics ; Protein Subunits/metabolism ; Saccharomyces cerevisiae Proteins/genetics ; Saccharomyces cerevisiae Proteins/metabolism ; Substrate Specificity
Czasopismo naukowe
Tytuł :
Cloning and characterization of the Bambusa oldhamii BoMDH-encoded malate dehydrogenase.
Autorzy :
Hsiao CJ; Department of Ecology and Conservation Biology, Texas A&M University, 2126 TAMU College Station, TX, 77843, USA.
Hsieh CY; Department of Pathology and Laboratory Medicine, Shin Kong Wu Ho-Su Memorial Hospital, No. 95, Wen Chang Road, Shih Lin District, Taipei City 111, Taiwan, ROC.
Hsieh LS; Department of Food Science, Tunghai University, No. 1727, Section 4, Taiwan Boulevard, Xitun District, Taichung, 40704, Taiwan, ROC. Electronic address: .
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Źródło :
Protein expression and purification [Protein Expr Purif] 2020 Oct; Vol. 174, pp. 105665. Date of Electronic Publication: 2020 May 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Bambusa*/enzymology
Bambusa*/genetics
Cloning, Molecular*
Malate Dehydrogenase*/biosynthesis
Malate Dehydrogenase*/chemistry
Malate Dehydrogenase*/genetics
Malate Dehydrogenase*/isolation & purification
Plant Proteins*/biosynthesis
Plant Proteins*/chemistry
Plant Proteins*/genetics
Plant Proteins*/isolation & purification
Escherichia coli/enzymology ; Escherichia coli/genetics ; Recombinant Proteins/biosynthesis ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Recombinant Proteins/isolation & purification
Czasopismo naukowe
Tytuł :
The maximum carboxylation rate of Rubisco affects CO 2 refixation in temperate broadleaved forest trees.
Autorzy :
Eckert D; Department of Forestry and Wood Technology, Linnaeus University, 351 95, Växjö, Sweden. Electronic address: .
Jensen AM; Department of Forestry and Wood Technology, Linnaeus University, 351 95, Växjö, Sweden.
Gu L; Climate Change Science Institute & Environmental Sciences Division, Oak Ridge National Laboratory, Oak Ridge, TN, 37831-6301, USA.
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Źródło :
Plant physiology and biochemistry : PPB [Plant Physiol Biochem] 2020 Oct; Vol. 155, pp. 330-337. Date of Electronic Publication: 2020 Jul 28.
Typ publikacji :
Journal Article
MeSH Terms :
Ribulose-Bisphosphate Carboxylase*/metabolism
Trees*/enzymology
Carbon Dioxide/*metabolism
Forests ; Photosynthesis ; Plant Leaves/anatomy & histology ; Plant Leaves/enzymology ; Sweden
Czasopismo naukowe
Tytuł :
Effect of Lactococcus lactis expressing phage endolysin on the late blowing defect of cheese caused by Clostridium tyrobutyricum.
Autorzy :
Garde S; Departamento de Tecnología de Alimentos, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Carretera de La Coruña km 7, 28040 Madrid, Spain.
Calzada J; Departamento de Tecnología de Alimentos, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Carretera de La Coruña km 7, 28040 Madrid, Spain.
Sánchez C; Departamento de Tecnología de Alimentos, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Carretera de La Coruña km 7, 28040 Madrid, Spain.
Gaya P; Departamento de Tecnología de Alimentos, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Carretera de La Coruña km 7, 28040 Madrid, Spain.
Narbad A; Gut Microbes and Health Institute Strategic Programme, Quadram Institute Bioscience, Colney, Norwich NR4 7UQ, UK.
Meijers R; Institute for Protein Innovation, 4 Blackfan Circle Rm921, Boston, MA 02115, United States.
Mayer MJ; Gut Microbes and Health Institute Strategic Programme, Quadram Institute Bioscience, Colney, Norwich NR4 7UQ, UK. Electronic address: .
Ávila M; Departamento de Tecnología de Alimentos, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Carretera de La Coruña km 7, 28040 Madrid, Spain. Electronic address: .
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Źródło :
International journal of food microbiology [Int J Food Microbiol] 2020 Sep 16; Vol. 329, pp. 108686. Date of Electronic Publication: 2020 May 26.
Typ publikacji :
Journal Article
MeSH Terms :
Bacteriophages*/enzymology
Bacteriophages*/genetics
Cheese/*microbiology
Clostridium tyrobutyricum/*drug effects
Endopeptidases/*genetics
Endopeptidases/*pharmacology
Food Microbiology/*methods
Lactococcus lactis/*genetics
Lactococcus lactis/enzymology ; Nisin/pharmacology ; Organisms, Genetically Modified
Czasopismo naukowe
Tytuł :
Potato E3 ubiquitin ligase PUB27 negatively regulates drought tolerance by mediating stomatal movement.
Autorzy :
Tang X; Gansu Provincial Key Laboratory of Aridland Crop Science, Gansu Agricultural University, Lanzhou, 730070, People's Republic of China; College of Life Science and Technology, Gansu Agricultural University, Lanzhou, 730070, People's Republic of China.
Ghimire S; Gansu Provincial Key Laboratory of Aridland Crop Science, Gansu Agricultural University, Lanzhou, 730070, People's Republic of China; College of Agronomy, Gansu Agricultural University, Lanzhou, 730070, People's Republic of China.
Liu W; Gansu Provincial Key Laboratory of Aridland Crop Science, Gansu Agricultural University, Lanzhou, 730070, People's Republic of China; College of Agronomy, Gansu Agricultural University, Lanzhou, 730070, People's Republic of China.
Fu X; Gansu Provincial Key Laboratory of Aridland Crop Science, Gansu Agricultural University, Lanzhou, 730070, People's Republic of China; College of Life Science and Technology, Gansu Agricultural University, Lanzhou, 730070, People's Republic of China.
Zhang H; Gansu Provincial Key Laboratory of Aridland Crop Science, Gansu Agricultural University, Lanzhou, 730070, People's Republic of China; College of Life Science and Technology, Gansu Agricultural University, Lanzhou, 730070, People's Republic of China.
Zhang N; Gansu Provincial Key Laboratory of Aridland Crop Science, Gansu Agricultural University, Lanzhou, 730070, People's Republic of China; College of Life Science and Technology, Gansu Agricultural University, Lanzhou, 730070, People's Republic of China.
Si H; Gansu Provincial Key Laboratory of Aridland Crop Science, Gansu Agricultural University, Lanzhou, 730070, People's Republic of China; College of Life Science and Technology, Gansu Agricultural University, Lanzhou, 730070, People's Republic of China. Electronic address: .
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Źródło :
Plant physiology and biochemistry : PPB [Plant Physiol Biochem] 2020 Sep; Vol. 154, pp. 557-563. Date of Electronic Publication: 2020 Jul 18.
Typ publikacji :
Journal Article
MeSH Terms :
Droughts*
Solanum tuberosum*/enzymology
Solanum tuberosum*/genetics
Plant Proteins/*metabolism
Plant Stomata/*physiology
Ubiquitin-Protein Ligases/*metabolism
Gene Expression Regulation, Plant ; Plant Proteins/genetics ; Plants, Genetically Modified/enzymology ; Stress, Physiological ; Ubiquitin-Protein Ligases/genetics
Czasopismo naukowe
Tytuł :
Overexpression of MsSiR enhances alkali tolerance in alfalfa (Medicago sativa L.) by increasing the glutathione content.
Autorzy :
Sun N; College of Life Sciences, Northeast Agricultural University, Harbin, 150030, China.
Song T; College of Animal Sciences and Technology, Northeast Agricultural University, Harbin, 150030, China.
Ma Z; College of Life Sciences, Northeast Agricultural University, Harbin, 150030, China.
Dong L; College of Life Sciences, Northeast Agricultural University, Harbin, 150030, China.
Zhan L; College of Life Sciences, Northeast Agricultural University, Harbin, 150030, China.
Xing Y; College of Life Sciences, Northeast Agricultural University, Harbin, 150030, China.
Liu J; College of Life Sciences, Northeast Agricultural University, Harbin, 150030, China.
Song J; College of Life Sciences, Northeast Agricultural University, Harbin, 150030, China.
Wang S; College of Life Sciences, Northeast Agricultural University, Harbin, 150030, China.
Cai H; College of Life Sciences, Northeast Agricultural University, Harbin, 150030, China. Electronic address: .
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Źródło :
Plant physiology and biochemistry : PPB [Plant Physiol Biochem] 2020 Sep; Vol. 154, pp. 538-546. Date of Electronic Publication: 2020 Jul 20.
Typ publikacji :
Journal Article
MeSH Terms :
Medicago sativa*/enzymology
Medicago sativa*/genetics
Alkalies/*adverse effects
Glutathione/*analysis
Oxidoreductases Acting on Sulfur Group Donors/*genetics
Plant Proteins/*genetics
Antioxidants/analysis ; Hydrogen Peroxide ; Plants, Genetically Modified/enzymology ; Stress, Physiological
Czasopismo naukowe
Tytuł :
The Ca -regulated protein kinase CIPK1 integrates plant responses to phosphate deficiency in Arabidopsis thaliana.
Autorzy :
Lu X; State Key Laboratory of Crop Stress Biology for Arid Areas and College of Life Sciences, Northwest A&F University, Yangling, China.
Li X; State Key Laboratory of Crop Stress Biology for Arid Areas and College of Life Sciences, Northwest A&F University, Yangling, China.
Xie D; State Key Laboratory of Crop Stress Biology for Arid Areas and College of Life Sciences, Northwest A&F University, Yangling, China.
Jiang C; College of Innovation and Experiment, Northwest A&F University, Yangling, China.
Wang C; State Key Laboratory of Crop Stress Biology for Arid Areas and College of Life Sciences, Northwest A&F University, Yangling, China.
Li L; State Key Laboratory of Crop Stress Biology for Arid Areas and College of Life Sciences, Northwest A&F University, Yangling, China.
Zhang Y; State Key Laboratory of Crop Stress Biology for Arid Areas and College of Life Sciences, Northwest A&F University, Yangling, China.
Tian H; College of Innovation and Experiment, Northwest A&F University, Yangling, China.
Gao H; State Key Laboratory of Crop Stress Biology for Arid Areas and College of Life Sciences, Northwest A&F University, Yangling, China.
Wang C; State Key Laboratory of Crop Stress Biology for Arid Areas and College of Life Sciences, Northwest A&F University, Yangling, China.
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Źródło :
Plant biology (Stuttgart, Germany) [Plant Biol (Stuttg)] 2020 Sep; Vol. 22 (5), pp. 753-760. Date of Electronic Publication: 2020 Jul 04.
Typ publikacji :
Journal Article
MeSH Terms :
Arabidopsis*/enzymology
Arabidopsis*/genetics
Arabidopsis Proteins*/genetics
Arabidopsis Proteins*/metabolism
Protein-Serine-Threonine Kinases*/genetics
Protein-Serine-Threonine Kinases*/metabolism
Gene Expression Regulation, Plant ; Mutation ; Phosphates/deficiency ; Phosphates/metabolism ; Plant Roots/enzymology ; Plant Roots/growth & development ; Signal Transduction/genetics ; Transcription Factors/metabolism
Czasopismo naukowe
Tytuł :
Characterization of an efficient extracellular cyanophycinase and its encoding cphE Strept. gene from Streptomyces pratensis strain YSM.
Autorzy :
Elbahloul Y; Biology Department, College of Science, Taibah University, Almadinah Almunawarah, Saudi Arabia; Botany and Microbiology Department, Faculty of Science, Alexandria University, 21511, Alexandria, Egypt; Institut Für Molekulare Mikrobiologie Und Biotechnologie, Westfälische Wilhelms-Universität, Münster, Corrensstraße 3, 48149, Münster, Germany. Electronic address: .
Steinbüchel A; Institut Für Molekulare Mikrobiologie Und Biotechnologie, Westfälische Wilhelms-Universität, Münster, Corrensstraße 3, 48149, Münster, Germany; Environmental Science Department, King Abdulaziz University, Jeddah, Saudi Arabia.
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Źródło :
Journal of biotechnology [J Biotechnol] 2020 Aug 10; Vol. 319, pp. 15-24. Date of Electronic Publication: 2020 May 27.
Typ publikacji :
Journal Article
MeSH Terms :
Bacterial Proteins*/chemistry
Bacterial Proteins*/genetics
Bacterial Proteins*/metabolism
Peptide Hydrolases*/chemistry
Peptide Hydrolases*/genetics
Peptide Hydrolases*/metabolism
Streptomyces*/enzymology
Streptomyces*/genetics
Streptomyces*/metabolism
Dipeptides/metabolism ; Extracellular Space/enzymology ; Extracellular Space/metabolism ; Serine Proteases
SCR Organism :
Streptomyces pratensis
Czasopismo naukowe
Tytuł :
Characterization of polyhydroxyalkanoate synthases from the marine bacterium Neptunomonas concharum JCM17730.
Autorzy :
Pu N; Beijing Key Laboratory of Bioprocess, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China.
Wang MR; Beijing Key Laboratory of Bioprocess, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China.
Li ZJ; Beijing Key Laboratory of Bioprocess, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China. Electronic address: .
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Źródło :
Journal of biotechnology [J Biotechnol] 2020 Aug 10; Vol. 319, pp. 69-73. Date of Electronic Publication: 2020 Jun 08.
Typ publikacji :
Journal Article
MeSH Terms :
Acyltransferases*/chemistry
Acyltransferases*/genetics
Acyltransferases*/metabolism
Bacterial Proteins*/chemistry
Bacterial Proteins*/genetics
Bacterial Proteins*/metabolism
Oceanospirillaceae*/enzymology
Oceanospirillaceae*/genetics
Aquatic Organisms/enzymology ; Aquatic Organisms/genetics ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Polyhydroxyalkanoates/metabolism ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism
SCR Organism :
Neptunomonas concharum
Czasopismo naukowe
Tytuł :
GSK-3 Inhibition as a Therapeutic Approach Against SARs CoV2: Dual Benefit of Inhibiting Viral Replication While Potentiating the Immune Response.
Autorzy :
Rudd CE; Centre de Recherche- Maisonneuve-Rosemont Hospital (CR-HMR), Montreal, QC, Canada.; Département de Medicine, Université de Montréal, Montreal, QC, Canada.; Department of Medicine, Division of Endocrinology & Medical Biochemistry, McGill University Health Center, Montreal, QC, Canada.
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Źródło :
Frontiers in immunology [Front Immunol] 2020 Jun 26; Vol. 11, pp. 1638. Date of Electronic Publication: 2020 Jun 26 (Print Publication: 2020).
Typ publikacji :
Journal Article; Review
MeSH Terms :
CD8-Positive T-Lymphocytes*/enzymology
CD8-Positive T-Lymphocytes*/immunology
CD8-Positive T-Lymphocytes*/pathology
Glycogen Synthase Kinase 3*
Killer Cells, Natural*/enzymology
Killer Cells, Natural*/immunology
Killer Cells, Natural*/pathology
Betacoronavirus/*physiology
Enzyme Inhibitors/*therapeutic use
Immunity, Cellular/*drug effects
Virus Replication/*drug effects
COVID-19 ; Coronavirus Infections/drug therapy ; Coronavirus Infections/enzymology ; Coronavirus Infections/immunology ; Humans ; Pandemics ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/enzymology ; Pneumonia, Viral/immunology ; SARS-CoV-2
Czasopismo naukowe
Tytuł :
Enhanced tolerance to inhibitors of Escherichia coli by heterologous expression of cyclopropane-fatty acid-acyl-phospholipid synthase (cfa) from Halomonas socia.
Autorzy :
Choi TR; Department of Microbial Engineering, College of Engineering, Konkuk University, Seoul, South Korea.
Song HS; Department of Microbial Engineering, College of Engineering, Konkuk University, Seoul, South Korea.
Han YH; Department of Microbial Engineering, College of Engineering, Konkuk University, Seoul, South Korea.
Park YL; Department of Microbial Engineering, College of Engineering, Konkuk University, Seoul, South Korea.
Park JY; Department of Microbial Engineering, College of Engineering, Konkuk University, Seoul, South Korea.
Yang SY; Department of Microbial Engineering, College of Engineering, Konkuk University, Seoul, South Korea.
Bhatia SK; Department of Microbial Engineering, College of Engineering, Konkuk University, Seoul, South Korea.; Institute for Ubiquitous Information Technology and Applications, Konkuk University, Seoul, 143-701, South Korea.
Gurav R; Department of Microbial Engineering, College of Engineering, Konkuk University, Seoul, South Korea.
Kim HJ; Department of Microbial Engineering, College of Engineering, Konkuk University, Seoul, South Korea.
Lee YK; Division of Life Sciences, Korea Polar Research Institute, Incheon, Republic of Korea.
Choi KY; Department of Environmental Engineering, College of Engineering, Ajou University, Suwon, Gyeonggi-do, South Korea.
Yang YH; Department of Microbial Engineering, College of Engineering, Konkuk University, Seoul, South Korea. .; Institute for Ubiquitous Information Technology and Applications, Konkuk University, Seoul, 143-701, South Korea. .
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Źródło :
Bioprocess and biosystems engineering [Bioprocess Biosyst Eng] 2020 May; Vol. 43 (5), pp. 909-918. Date of Electronic Publication: 2020 Jan 27.
Typ publikacji :
Journal Article
MeSH Terms :
Bacterial Proteins*/biosynthesis
Bacterial Proteins*/genetics
Escherichia coli*/enzymology
Escherichia coli*/genetics
Gene Expression*
Methyltransferases*/biosynthesis
Methyltransferases*/genetics
Microorganisms, Genetically-Modified*/enzymology
Microorganisms, Genetically-Modified*/genetics
Osmotic Pressure/*drug effects
Sodium Chloride/*pharmacology
Cupriavidus necator/enzymology ; Cupriavidus necator/genetics ; Halomonas/enzymology ; Halomonas/genetics ; Recombinant Proteins/biosynthesis ; Recombinant Proteins/genetics
SCR Organism :
Halomonas socia
Czasopismo naukowe
Tytuł :
Bioinformatic and experimental evidence for suicidal and catalytic plant THI4s.
Autorzy :
Joshi J; Horticultural Sciences Department, University of Florida, Gainesville, FL, U.S.A.
Beaudoin GAW; Horticultural Sciences Department, University of Florida, Gainesville, FL, U.S.A.
Patterson JA; Horticultural Sciences Department, University of Florida, Gainesville, FL, U.S.A.
García-García JD; Horticultural Sciences Department, University of Florida, Gainesville, FL, U.S.A.
Belisle CE; Horticultural Sciences Department, University of Florida, Gainesville, FL, U.S.A.
Chang LY; Horticultural Sciences Department, University of Florida, Gainesville, FL, U.S.A.
Li L; ARC Centre of Excellence in Plant Energy Biology, School of Molecular Sciences, University of Western Australia, Crawley 6009 WA, Australia.; Department of Plant Biology and Ecology, College of Life Sciences, Nankai University, Tianjin 300071, China.
Duncan O; ARC Centre of Excellence in Plant Energy Biology, School of Molecular Sciences, University of Western Australia, Crawley 6009 WA, Australia.
Millar AH; ARC Centre of Excellence in Plant Energy Biology, School of Molecular Sciences, University of Western Australia, Crawley 6009 WA, Australia.
Hanson AD; Horticultural Sciences Department, University of Florida, Gainesville, FL, U.S.A.
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Źródło :
The Biochemical journal [Biochem J] 2020 Jun 12; Vol. 477 (11), pp. 2055-2069.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Arabidopsis*/enzymology
Arabidopsis*/genetics
Arabidopsis Proteins*/chemistry
Arabidopsis Proteins*/genetics
Arabidopsis Proteins*/metabolism
Ligases*/chemistry
Ligases*/genetics
Ligases*/metabolism
Models, Molecular*
Plants, Genetically Modified*/enzymology
Plants, Genetically Modified*/genetics
Thiamine*/biosynthesis
Thiamine*/genetics
Thiazoles/*metabolism
Catalysis ; Computational Biology ; Escherichia coli/enzymology ; Escherichia coli/genetics ; Genetic Complementation Test ; Protein Domains
Czasopismo naukowe
Tytuł :
Biliary damage and liver fibrosis are ameliorated in a novel mouse model lacking l-histidine decarboxylase/histamine signaling.
Autorzy :
Kennedy L; Richard L. Roudebush VA Medical Center, and Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
Meadows V; Richard L. Roudebush VA Medical Center, and Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
Demieville J; Central Texas Veterans Health Care System, Temple, TX, USA.
Hargrove L; Department of Medical Physiology, Texas A&M University College of Medicine, Bryan, USA.
Virani S; Department of Medical Physiology, Texas A&M University College of Medicine, Bryan, USA.
Glaser S; Department of Medical Physiology, Texas A&M University College of Medicine, Bryan, USA.
Zhou T; Department of Medical Physiology, Texas A&M University College of Medicine, Bryan, USA.
Rinehart E; Department of Medical Physiology, Texas A&M University College of Medicine, Bryan, USA.
Jaeger V; Department of Medical Physiology, Texas A&M University College of Medicine, Bryan, USA.
Kyritsi K; Richard L. Roudebush VA Medical Center, and Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
Pham L; Richard L. Roudebush VA Medical Center, and Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.; Department of Science and Mathematics, Texas A&M University, Central Texas, Killeen, TX, USA.
Alpini G; Richard L. Roudebush VA Medical Center, and Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.; Central Texas Veterans Health Care System, Temple, TX, USA.; Department of Medical Physiology, Texas A&M University College of Medicine, Bryan, USA.
Francis H; Richard L. Roudebush VA Medical Center, and Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA. .; Central Texas Veterans Health Care System, Temple, TX, USA. .; Department of Medical Physiology, Texas A&M University College of Medicine, Bryan, USA. .
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Źródło :
Laboratory investigation; a journal of technical methods and pathology [Lab Invest] 2020 Jun; Vol. 100 (6), pp. 837-848. Date of Electronic Publication: 2020 Feb 13.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Cholangitis, Sclerosing*/enzymology
Cholangitis, Sclerosing*/metabolism
Cholangitis, Sclerosing*/pathology
Histidine Decarboxylase*/genetics
Histidine Decarboxylase*/metabolism
Liver Cirrhosis*/enzymology
Liver Cirrhosis*/metabolism
Liver Cirrhosis*/pathology
Histamine/*metabolism
Signal Transduction/*genetics
Animals ; Disease Models, Animal ; Liver/cytology ; Liver/enzymology ; Liver/metabolism ; Liver/pathology ; Male ; Mice ; Mice, Knockout
Czasopismo naukowe
Tytuł :
Potassium alleviates ammonium toxicity in rice by reducing its uptake through activation of plasma membrane H -ATPase to enhance proton extrusion.
Autorzy :
Weng L; Fujian Provincial Key laboratory of Plant Functional Biology, College of Resources and Environmental Sciences in China Agricultural University, Beijing, 100083, China; Fujian Provincial Key Laboratory of Plant Functional Biology and College of Life Sciences, Center for Plant Water-use and Nutrition Regulation and College of Resources and Environment in Fujian Agriculture and Forestry University, Fuzhou, 350002, China.
Zhang M; Jiangsu Collaborative Innovation Center for Solid Organic Waste Resource Utilization, Jiangsu Provincial Key Lab for Organic Solid Waste Utilization, National Engineering Research Center for Organic-based Fertilizers, Nanjing Agricultural University, Nanjing, 210095, China.
Wang K; Fujian Provincial Key Laboratory of Plant Functional Biology and College of Life Sciences, Center for Plant Water-use and Nutrition Regulation and College of Resources and Environment in Fujian Agriculture and Forestry University, Fuzhou, 350002, China.
Chen G; Jiangsu Collaborative Innovation Center for Solid Organic Waste Resource Utilization, Jiangsu Provincial Key Lab for Organic Solid Waste Utilization, National Engineering Research Center for Organic-based Fertilizers, Nanjing Agricultural University, Nanjing, 210095, China.
Ding M; Jiangsu Collaborative Innovation Center for Solid Organic Waste Resource Utilization, Jiangsu Provincial Key Lab for Organic Solid Waste Utilization, National Engineering Research Center for Organic-based Fertilizers, Nanjing Agricultural University, Nanjing, 210095, China.
Yuan W; Fujian Provincial Key Laboratory of Plant Functional Biology and College of Life Sciences, Center for Plant Water-use and Nutrition Regulation and College of Resources and Environment in Fujian Agriculture and Forestry University, Fuzhou, 350002, China. Electronic address: .
Zhu Y; Jiangsu Collaborative Innovation Center for Solid Organic Waste Resource Utilization, Jiangsu Provincial Key Lab for Organic Solid Waste Utilization, National Engineering Research Center for Organic-based Fertilizers, Nanjing Agricultural University, Nanjing, 210095, China.
Xu W; Fujian Provincial Key Laboratory of Plant Functional Biology and College of Life Sciences, Center for Plant Water-use and Nutrition Regulation and College of Resources and Environment in Fujian Agriculture and Forestry University, Fuzhou, 350002, China.
Xu F; Fujian Provincial Key Laboratory of Plant Functional Biology and College of Life Sciences, Center for Plant Water-use and Nutrition Regulation and College of Resources and Environment in Fujian Agriculture and Forestry University, Fuzhou, 350002, China. Electronic address: .
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Źródło :
Plant physiology and biochemistry : PPB [Plant Physiol Biochem] 2020 Jun; Vol. 151, pp. 429-437. Date of Electronic Publication: 2020 Apr 02.
Typ publikacji :
Journal Article
MeSH Terms :
Ammonium Compounds*/metabolism
Ammonium Compounds*/toxicity
Oryza*/drug effects
Oryza*/enzymology
Potassium*/pharmacology
Proton-Translocating ATPases*/metabolism
Cell Membrane/drug effects ; Cell Membrane/enzymology ; Enzyme Activation/drug effects ; Plant Roots/drug effects ; Plant Roots/enzymology
Czasopismo naukowe
Tytuł :
Towards identification of molecular mechanism in which the overexpression of wheat cytosolic and plastid glutamine synthetases in tobacco enhanced drought tolerance.
Autorzy :
Yu H; College of Life Sciences, Henan Agricultural University, Zhengzhou, 450002, Henan, China.
Zhang Y; College of Life Sciences, Henan Agricultural University, Zhengzhou, 450002, Henan, China.
Zhang Z; Collaborative Innovation Center of Henan Grain Crops, Henan Agriculture University, Zhengzhou, 450000, China.
Zhang J; Collaborative Innovation Center of Henan Grain Crops, Henan Agriculture University, Zhengzhou, 450000, China.
Wei Y; Collaborative Innovation Center of Henan Grain Crops, Henan Agriculture University, Zhengzhou, 450000, China.
Jia X; Collaborative Innovation Center of Henan Grain Crops, Henan Agriculture University, Zhengzhou, 450000, China.
Wang X; College of Life Sciences, Henan Agricultural University, Zhengzhou, 450002, Henan, China; Collaborative Innovation Center of Henan Grain Crops, Henan Agriculture University, Zhengzhou, 450000, China; State Key Laboratory of Wheat and Maize Crop Science in China, Henan Agriculture University, Zhengzhou, 450000, China. Electronic address: .
Ma X; Collaborative Innovation Center of Henan Grain Crops, Henan Agriculture University, Zhengzhou, 450000, China. Electronic address: .
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Źródło :
Plant physiology and biochemistry : PPB [Plant Physiol Biochem] 2020 Jun; Vol. 151, pp. 608-620. Date of Electronic Publication: 2020 Apr 18.
Typ publikacji :
Journal Article
MeSH Terms :
Droughts*
Gene Expression*
Glutamate-Ammonia Ligase*/genetics
Glutamate-Ammonia Ligase*/metabolism
Stress, Physiological*/genetics
Tobacco*/genetics
Triticum*/enzymology
Triticum*/genetics
Cytosol/enzymology ; Glutamine ; Plant Leaves/enzymology ; Plant Leaves/genetics ; Plastids/enzymology
Czasopismo naukowe
Tytuł :
Genetic alteration, RNA expression, and DNA methylation profiling of coronavirus disease 2019 (COVID-19) receptor ACE2 in malignancies: a pan-cancer analysis.
Autorzy :
Chai P; Department of Ophthalmology, Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, 200025, People's Republic of China.
Yu J
Ge S; Department of Ophthalmology, Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, 200025, People's Republic of China. .
Jia R; Department of Ophthalmology, Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, 200025, People's Republic of China. .
Fan X; Department of Ophthalmology, Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, 200025, People's Republic of China. .
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Źródło :
Journal of hematology & oncology [J Hematol Oncol] 2020 May 04; Vol. 13 (1), pp. 43. Date of Electronic Publication: 2020 May 04.
Typ publikacji :
Letter; Research Support, Non-U.S. Gov't
MeSH Terms :
Betacoronavirus*
Coronavirus Infections*/enzymology
Coronavirus Infections*/etiology
Coronavirus Infections*/virology
Pandemics*
Peptidyl-Dipeptidase A*/biosynthesis
Peptidyl-Dipeptidase A*/genetics
Pneumonia, Viral*/enzymology
Pneumonia, Viral*/etiology
Pneumonia, Viral*/virology
Receptors, Virus*/biosynthesis
Receptors, Virus*/genetics
Neoplasms/*enzymology
Angiotensin-Converting Enzyme 2 ; COVID-19 ; DNA Methylation ; DNA, Neoplasm/metabolism ; Humans ; Neoplasms/complications ; RNA/biosynthesis ; Receptors, Coronavirus ; SARS-CoV-2
Raport

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