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Tytuł:
Deciphering cancer cell state plasticity with single-cell genomics and artificial intelligence.
Autorzy:
Holton E; Garvan Weizmann Centre for Cellular Genomics, Garvan Institute of Medical Research, The Kinghorn Cancer Centre, Darlinghurst, NSW, 2010, Australia.; School of Biomedical Science, Faculty of Medicine UNSW Sydney, Kensington, NSW, 2010, Australia.; UNSW Cellular Genomics Futures Institute, University of New South Wales, Sydney, NSW, 2052, Australia.
Muskovic W; Garvan Weizmann Centre for Cellular Genomics, Garvan Institute of Medical Research, The Kinghorn Cancer Centre, Darlinghurst, NSW, 2010, Australia.; UNSW Cellular Genomics Futures Institute, University of New South Wales, Sydney, NSW, 2052, Australia.
Powell JE; Garvan Weizmann Centre for Cellular Genomics, Garvan Institute of Medical Research, The Kinghorn Cancer Centre, Darlinghurst, NSW, 2010, Australia. .; School of Biomedical Science, Faculty of Medicine UNSW Sydney, Kensington, NSW, 2010, Australia. .; UNSW Cellular Genomics Futures Institute, University of New South Wales, Sydney, NSW, 2052, Australia. .
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Źródło:
Genome medicine [Genome Med] 2024 Feb 26; Vol. 16 (1), pp. 36. Date of Electronic Publication: 2024 Feb 26.
Typ publikacji:
Journal Article
MeSH Terms:
Epithelial-Mesenchymal Transition*
Neoplasms*/genetics
Neoplasms*/pathology
Humans ; Artificial Intelligence ; Cell Plasticity/genetics ; Genomics/methods
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Oxidative stress regulation and related metabolic pathways in epithelial-mesenchymal transition of breast cancer stem cells.
Autorzy:
Farahzadi R; Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Valipour B; Department of Anatomical Sciences, Sarab Faculty of Medical Sciences, Sarab, Iran.
Fathi E; Department of Clinical Sciences, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran.
Pirmoradi S; Cellular and Molecular Research Center, Cellular and Molecular Medicine Research Institute, Urmia University of Medical Sciences, Urmia, Iran.
Molavi O; Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.; Molecular Medicine Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Montazersaheb S; Molecular Medicine Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. .
Sanaat Z; Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. .
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Źródło:
Stem cell research & therapy [Stem Cell Res Ther] 2023 Nov 28; Vol. 14 (1), pp. 342. Date of Electronic Publication: 2023 Nov 28.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Epithelial-Mesenchymal Transition*
Breast Neoplasms*/pathology
Humans ; Female ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Oxidative Stress ; Neoplastic Stem Cells/metabolism ; Snail Family Transcription Factors/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
SIRT1 mediates the inhibitory effect of Dapagliflozin on EndMT by inhibiting the acetylation of endothelium Notch1.
Autorzy:
Wang W; Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, 246 Xuefu Road, Harbin, 150086, China.; Key Laboratory of Myocardial Ischemia, Ministry of Education, Harbin Medical University, Harbin, China.
Li Y; Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, 246 Xuefu Road, Harbin, 150086, China.; Key Laboratory of Myocardial Ischemia, Ministry of Education, Harbin Medical University, Harbin, China.
Zhang Y; Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, 246 Xuefu Road, Harbin, 150086, China.; Key Laboratory of Myocardial Ischemia, Ministry of Education, Harbin Medical University, Harbin, China.
Ye T; Department of Organic Chemistry, College of Pharmacy, Harbin Medical University, Harbin, China.
Wang K; Department of Organic Chemistry, College of Pharmacy, Harbin Medical University, Harbin, China.
Li S; Department of Biopharmaceutical Sciences, College of Pharmacy, Harbin Medical University, Harbin, 150081, China. .; State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), Harbin, China. .
Zhang Y; Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, 246 Xuefu Road, Harbin, 150086, China. yaozhang_.; Key Laboratory of Myocardial Ischemia, Ministry of Education, Harbin Medical University, Harbin, China. yaozhang_.
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Źródło:
Cardiovascular diabetology [Cardiovasc Diabetol] 2023 Nov 28; Vol. 22 (1), pp. 331. Date of Electronic Publication: 2023 Nov 28.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Sirtuin 1*/metabolism
Epithelial-Mesenchymal Transition*
Humans ; Animals ; Mice ; Acetylation ; Endothelium ; Human Umbilical Vein Endothelial Cells/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
SMC1A facilitates gastric cancer cell proliferation, migration, and invasion via promoting SNAIL activated EMT.
Autorzy:
Liu Y; Department of Geriatrics Surgery, The Second Xiangya Hospital, Central South University, No. 139 Renmin Road, Furong District, Changsha City, 410011, Hunan Province, China.
Fang X; Department of General Surgery, Yantai Qishan Hospital, Yantai, 264000, Shandong, China.
Wang Q; Department of Oncology, The Affiliated ZhuZhou Hospital of XiangYa Medical College, Central South University, ZhuZhou, 412007, Hunan, China.
Xiao D; Department of General Surgery, Shekou People's Hospital, Shenzhen, 518000, Guangdong, China.
Zhou T; Department of Geriatrics Surgery, The Second Xiangya Hospital, Central South University, No. 139 Renmin Road, Furong District, Changsha City, 410011, Hunan Province, China.
Kang K; Department of Geriatrics Surgery, The Second Xiangya Hospital, Central South University, No. 139 Renmin Road, Furong District, Changsha City, 410011, Hunan Province, China.
Peng Z; Department of Geriatrics Surgery, The Second Xiangya Hospital, Central South University, No. 139 Renmin Road, Furong District, Changsha City, 410011, Hunan Province, China.
Ren F; Department of Geriatrics Surgery, The Second Xiangya Hospital, Central South University, No. 139 Renmin Road, Furong District, Changsha City, 410011, Hunan Province, China. .
Zhou J; Department of Geriatrics Surgery, The Second Xiangya Hospital, Central South University, No. 139 Renmin Road, Furong District, Changsha City, 410011, Hunan Province, China. .
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Źródło:
BMC gastroenterology [BMC Gastroenterol] 2023 Aug 04; Vol. 23 (1), pp. 268. Date of Electronic Publication: 2023 Aug 04.
Typ publikacji:
Journal Article
MeSH Terms:
Epithelial-Mesenchymal Transition*/genetics
Stomach Neoplasms*/pathology
Chromosomal Proteins, Non-Histone*/genetics
Humans ; Cell Line, Tumor ; Cell Movement/genetics ; Cell Proliferation/genetics ; Gene Expression Regulation, Neoplastic ; Neoplasm Invasiveness
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Lymph node metastasis related gene BICC1 promotes tumor progression by promoting EMT and immune infiltration in pancreatic cancer.
Autorzy:
Meng F; Minimally invasive Center of Hepatobiliary and Pancreatic surgery, The Second Hospital of Harbin, Harbin, Heilongjiang, China.
Hua S; Hepatobiliary and Pancreatic Surgery, The Second Hospital of Harbin, Harbin, Heilongjiang, China.
Chen X; Hepatobiliary and Pancreatic Surgery, The Second Hospital of Harbin, Harbin, Heilongjiang, China.
Meng N; Department of Hepatopancreatobiliary Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
Lan T; Department of Rehabilitation, The Second Hospital of Harbin, Ward A, Harbin, Heilongjiang, China. .
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Źródło:
BMC medical genomics [BMC Med Genomics] 2023 Oct 25; Vol. 16 (1), pp. 263. Date of Electronic Publication: 2023 Oct 25.
Typ publikacji:
Journal Article
MeSH Terms:
Epithelial-Mesenchymal Transition*/genetics
Pancreatic Neoplasms*/genetics
Pancreatic Neoplasms*/pathology
RNA-Binding Proteins*/genetics
Humans ; Lymphatic Metastasis ; Prognosis ; Pancreatic Neoplasms
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Arginase-1 promotes lens epithelial-to-mesenchymal transition in different models of anterior subcapsular cataract.
Autorzy:
Li Q; Department of Cataract, Tianjin Eye Hospital, Tianjin, China.; Tianjin Key Lab of Ophthalmology and Visual Science, Tianjin, China.
Wang Y; Department of Cataract, Tianjin Eye Hospital, Tianjin, China.; Tianjin Key Lab of Ophthalmology and Visual Science, Tianjin, China.
Shi L; Department of Cataract, Tianjin Eye Hospital, Tianjin, China.; Tianjin Key Lab of Ophthalmology and Visual Science, Tianjin, China.
Wang Q; Clinical College of Ophthalmology, Tianjin Medical University, Tianjin, China.; Heze Medical College, Heze, Shandong, China.
Yang G; School of Microelectronics, Tianjin University, Tianjin, China.
Deng L; Department of Cataract, Tianjin Eye Hospital, Tianjin, China.; Tianjin Key Lab of Ophthalmology and Visual Science, Tianjin, China.
Tian Y; Department of Cataract, Tianjin Eye Hospital, Tianjin, China.; Tianjin Key Lab of Ophthalmology and Visual Science, Tianjin, China.
Hua X; Tianjin Aier Eye Hospital, Tianjin University, Tianjin, China. .
Yuan X; Department of Cataract, Tianjin Eye Hospital, Tianjin, China. yuanxy_.; Tianjin Key Lab of Ophthalmology and Visual Science, Tianjin, China. yuanxy_.
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Źródło:
Cell communication and signaling : CCS [Cell Commun Signal] 2023 Sep 18; Vol. 21 (1), pp. 236. Date of Electronic Publication: 2023 Sep 18.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Arginase*
Cataract*
Epithelial-Mesenchymal Transition*
Animals ; Humans ; Mice ; Ki-67 Antigen ; Mice, Inbred C57BL ; Superoxides ; Transforming Growth Factor beta2 ; Vimentin
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The B56γ3-containing protein phosphatase 2A attenuates p70S6K-mediated negative feedback loop to enhance AKT-facilitated epithelial-mesenchymal transition in colorectal cancer.
Autorzy:
Hsiao KC; Institute of Molecular Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan, ROC.
Ruan SY; Institute of Molecular Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan, ROC.
Chen SM; Institute of Molecular Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan, ROC.
Lai TY; Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan, ROC.
Chan RH; Department of Surgery, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan, ROC.
Zhang YM; Institute of Molecular Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan, ROC.
Chu CA; Department of Pathology, College of Medicine, National Cheng Kung University, Tainan, Taiwan, ROC.
Cheng HC; Department of Biochemistry and Molecular Biology, College of Medicine, National Cheng Kung University, Tainan, Taiwan, ROC.
Tsai HW; Department of Pathology, College of Medicine, National Cheng Kung University, Tainan, Taiwan, ROC.
Tu YF; Department of Pediatrics, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan, ROC.
Law BK; Department of Pharmacology and Therapeutics and the UF-Health Cancer Center, University of Florida, Gainesville, FL, 32610, USA.
Chang TT; Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan, ROC.
Chow NH; Department of Pathology, College of Medicine, National Cheng Kung University, Tainan, Taiwan, ROC.
Chiang CW; Institute of Molecular Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan, ROC. .; Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan, ROC. .
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Źródło:
Cell communication and signaling : CCS [Cell Commun Signal] 2023 Jul 10; Vol. 21 (1), pp. 172. Date of Electronic Publication: 2023 Jul 10.
Typ publikacji:
Video-Audio Media; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Epithelial-Mesenchymal Transition*
Colorectal Neoplasms*
Humans ; Protein Phosphatase 2 ; Proto-Oncogene Proteins c-akt ; Feedback ; Ribosomal Protein S6 Kinases, 70-kDa ; Phosphatidylinositol 3-Kinases ; Fluorouracil
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Identification of mesenchymal-to-epithelial transition during heart regeneration through genetic lineage tracing.
Autorzy:
Gao Z; School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China.
Lu Z; School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China.
Meng J; Institute for Regenerative Medicine, Shanghai East Hospital, Frontier Science Center for Stem Cell Research, School of Life Science and Technology, Tongji University, Shanghai, 200092, China.
Lin CP; School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China.
Zhang H; School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China. .
Tang J; Institute for Regenerative Medicine, Shanghai East Hospital, Frontier Science Center for Stem Cell Research, School of Life Science and Technology, Tongji University, Shanghai, 200092, China. .
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Źródło:
Stem cell research & therapy [Stem Cell Res Ther] 2023 Jun 14; Vol. 14 (1), pp. 161. Date of Electronic Publication: 2023 Jun 14.
Typ publikacji:
Letter; Research Support, Non-U.S. Gov't
MeSH Terms:
Heart*
Epithelial-Mesenchymal Transition*
Animals ; Cell Differentiation ; Cell Lineage/genetics ; Fibroblasts ; Mammals
Raport
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
EMT/MET plasticity in cancer and Go-or-Grow decisions in quiescence: the two sides of the same coin?
Autorzy:
Akhmetkaliyev A; Department of Biomedical Sciences, Nazarbayev University School of Medicine, Astana, 020000, Kazakhstan.
Alibrahim N; Al-Mana College for Medical Science, Ahsa, Saudi Arabia.
Shafiee D; Department of Biomedical Sciences, Nazarbayev University School of Medicine, Astana, 020000, Kazakhstan.
Tulchinsky E; Department of Biomedical Sciences, Nazarbayev University School of Medicine, Astana, 020000, Kazakhstan. .; Department of Genetics and Genome Biology, University of Leicester, Leicester, UK. .
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Źródło:
Molecular cancer [Mol Cancer] 2023 May 31; Vol. 22 (1), pp. 90. Date of Electronic Publication: 2023 May 31.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
Epithelial-Mesenchymal Transition*/genetics
Neoplasms*/genetics
Neoplasms*/pathology
Humans ; Cell Differentiation ; Cell Division ; Signal Transduction
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Disheveled3 enhanced EMT and cancer stem-like cells properties via Wnt/β-catenin/c-Myc/SOX2 pathway in colorectal cancer.
Autorzy:
Li Z; Oncology Department of Chengdu Seventh People's Hospital, Chengdu, China. .; School of Biological Sciences and Technology, Chengdu Medical College, Chengdu, 610500, China. .
Yang Z; Pathology Department of Deyang People's Hospital, Deyang, 618000, China.; School of Biological Sciences and Technology, Chengdu Medical College, Chengdu, 610500, China.
Liu W; The Second Affiliated Hospital of Chengdu Medical College, China National Nuclear Corporation 416 Hospital, Chengdu, 61051, China.; School of Biological Sciences and Technology, Chengdu Medical College, Chengdu, 610500, China.
Zhu W; School of Biological Sciences and Technology, Chengdu Medical College, Chengdu, 610500, China.
Yin L; School of Biological Sciences and Technology, Chengdu Medical College, Chengdu, 610500, China.
Han Z; School of Biological Sciences and Technology, Chengdu Medical College, Chengdu, 610500, China.
Xian Y; School of Biological Sciences and Technology, Chengdu Medical College, Chengdu, 610500, China.
Wen J; School of Biological Sciences and Technology, Chengdu Medical College, Chengdu, 610500, China.
Tang H; School of Biological Sciences and Technology, Chengdu Medical College, Chengdu, 610500, China.
Lin X; School of Biological Sciences and Technology, Chengdu Medical College, Chengdu, 610500, China.
Yang Y; School of Biological Sciences and Technology, Chengdu Medical College, Chengdu, 610500, China.
Wang J; The Second Affiliated Hospital of Chengdu Medical College, China National Nuclear Corporation 416 Hospital, Chengdu, 61051, China. .; School of Biological Sciences and Technology, Chengdu Medical College, Chengdu, 610500, China. .
Zhang K; The Second Affiliated Hospital of Chengdu Medical College, China National Nuclear Corporation 416 Hospital, Chengdu, 61051, China. .; School of Biological Sciences and Technology, Chengdu Medical College, Chengdu, 610500, China. .
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Źródło:
Journal of translational medicine [J Transl Med] 2023 May 05; Vol. 21 (1), pp. 302. Date of Electronic Publication: 2023 May 05.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
beta Catenin*/metabolism
Colorectal Neoplasms*/pathology
Epithelial-Mesenchymal Transition*
Wnt Signaling Pathway*
Dishevelled Proteins*/genetics
Animals ; Mice ; Cell Line, Tumor ; Cell Movement ; Cell Proliferation ; Gene Expression Regulation, Neoplastic ; Mice, Nude ; Humans ; Neoplastic Stem Cells
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Transcriptome exploration of ferroptosis-related genes in TGFβ- induced lens epithelial to mesenchymal transition during posterior capsular opacification development.
Autorzy:
Fan C; Eye Center of Xiangya Hospital, Central South University, Changsha, China.; Hunan Key Laboratory of Ophthalmology, Xiangya Hospital, Central South University, Changsha, China.; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China.
Wang C; Eye Center of Xiangya Hospital, Central South University, Changsha, China.; Hunan Key Laboratory of Ophthalmology, Xiangya Hospital, Central South University, Changsha, China.; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China.
Wang Y; Department of Biological Sciences, University of Delaware, Newark, USA.
Jiang J; Eye Center of Xiangya Hospital, Central South University, Changsha, China. jiang_.; Hunan Key Laboratory of Ophthalmology, Xiangya Hospital, Central South University, Changsha, China. jiang_.; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China. jiang_.
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Źródło:
BMC genomics [BMC Genomics] 2024 Apr 09; Vol. 25 (1), pp. 352. Date of Electronic Publication: 2024 Apr 09.
Typ publikacji:
Journal Article
MeSH Terms:
Ferroptosis*/genetics
Capsule Opacification*/genetics
Capsule Opacification*/metabolism
Humans ; Transforming Growth Factor beta2/genetics ; Transforming Growth Factor beta2/metabolism ; Transforming Growth Factor beta2/pharmacology ; Transcriptome ; Epithelial-Mesenchymal Transition/genetics ; Blotting, Western ; Epithelial Cells/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
SUMOylation of annexin A6 retards cell migration and tumor growth by suppressing RHOU/AKT1-involved EMT in hepatocellular carcinoma.
Autorzy:
Yang Y; Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, No.17, 3rd Section of People's South Road, Chengdu, 610041, People's Republic of China.
Huang L; Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, No.17, 3rd Section of People's South Road, Chengdu, 610041, People's Republic of China.
Zhang N; Department of Medical Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, 610041, China.
Deng YN; Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, No.17, 3rd Section of People's South Road, Chengdu, 610041, People's Republic of China.
Cao X; Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, No.17, 3rd Section of People's South Road, Chengdu, 610041, People's Republic of China.
Liang Y; Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, No.17, 3rd Section of People's South Road, Chengdu, 610041, People's Republic of China.
Hou H; Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, No.17, 3rd Section of People's South Road, Chengdu, 610041, People's Republic of China.
Luo Y; Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, No.17, 3rd Section of People's South Road, Chengdu, 610041, People's Republic of China.
Yang Y; Department of Medical Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, 610041, China.
Li Q; Department of Medical Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, 610041, China.
Liang S; Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, No.17, 3rd Section of People's South Road, Chengdu, 610041, People's Republic of China. .
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Źródło:
Cell communication and signaling : CCS [Cell Commun Signal] 2024 Apr 02; Vol. 22 (1), pp. 206. Date of Electronic Publication: 2024 Apr 02.
Typ publikacji:
Journal Article
MeSH Terms:
Carcinoma, Hepatocellular*/pathology
Liver Neoplasms*/pathology
Animals ; Humans ; Mice ; Annexin A6/genetics ; Annexin A6/metabolism ; Cell Line, Tumor ; Cell Movement/genetics ; Cell Proliferation ; Chromatography, Liquid ; Epithelial-Mesenchymal Transition/genetics ; Gene Expression Regulation, Neoplastic ; Proto-Oncogene Proteins c-akt/metabolism ; rho GTP-Binding Proteins/metabolism ; Sumoylation ; Tandem Mass Spectrometry
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Wnt5a/β-catenin-mediated epithelial-mesenchymal transition: a key driver of subretinal fibrosis in neovascular age-related macular degeneration.
Autorzy:
Liu D; Department of Ophthalmology of Tongji Hospital and Laboratory of Clinical and Visual Sciences of Tongji Eye Institute, School of Medicine, Tongji University, Shanghai, China.
Du J; Department of Ophthalmology, Shanghai General Hospital (Shanghai First People's Hospital), Shanghai Jiao Tong University School of Medicine, Shanghai, China.; Shanghai Key Laboratory of Ocular Fundus Diseases, National Clinical Research Center for Eye Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai Eye Research Institute, Shanghai, China.
Xie H; Department of Ophthalmology, Shanghai General Hospital (Shanghai First People's Hospital), Shanghai Jiao Tong University School of Medicine, Shanghai, China.; Shanghai Key Laboratory of Ocular Fundus Diseases, National Clinical Research Center for Eye Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai Eye Research Institute, Shanghai, China.
Tian H; Department of Ophthalmology of Tongji Hospital and Laboratory of Clinical and Visual Sciences of Tongji Eye Institute, School of Medicine, Tongji University, Shanghai, China.
Lu L; Department of Ophthalmology of Tongji Hospital and Laboratory of Clinical and Visual Sciences of Tongji Eye Institute, School of Medicine, Tongji University, Shanghai, China.
Zhang C; Department of Ophthalmology, Shanghai General Hospital (Shanghai First People's Hospital), Shanghai Jiao Tong University School of Medicine, Shanghai, China. .; Shanghai Key Laboratory of Ocular Fundus Diseases, National Clinical Research Center for Eye Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai Eye Research Institute, Shanghai, China. .
Xu GT; Department of Ophthalmology of Tongji Hospital and Laboratory of Clinical and Visual Sciences of Tongji Eye Institute, School of Medicine, Tongji University, Shanghai, China. .
Zhang J; Department of Ophthalmology, Shanghai General Hospital (Shanghai First People's Hospital), Shanghai Jiao Tong University School of Medicine, Shanghai, China. .; Shanghai Key Laboratory of Ocular Fundus Diseases, National Clinical Research Center for Eye Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai Eye Research Institute, Shanghai, China. .
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Źródło:
Journal of neuroinflammation [J Neuroinflammation] 2024 Mar 26; Vol. 21 (1), pp. 75. Date of Electronic Publication: 2024 Mar 26.
Typ publikacji:
Journal Article
MeSH Terms:
beta Catenin*/metabolism
Macular Degeneration*/metabolism
Sulfonamides*
Humans ; Male ; Animals ; Mice ; Wnt-5a Protein ; Mice, Inbred C57BL ; Retinal Pigment Epithelium/metabolism ; Epithelial-Mesenchymal Transition ; Fibrosis ; RNA, Small Interfering/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The crosstalk between cholangiocytes and hepatic stellate cells promotes the progression of epithelial-mesenchymal transition and periductal fibrosis during Clonorchis sinensis infection.
Autorzy:
Yi J; Department of Biochemistry, Asan Medical Institute of Convergence Science and Technology (AMIST), University of Ulsan College of Medicine and Asan Medical Center (AMC), 88 Olympic-Ro 43-Gil, Songpa-gu, Seoul, 05505, Republic of Korea.
Jeong JH; Department of Biochemistry, Asan Medical Institute of Convergence Science and Technology (AMIST), University of Ulsan College of Medicine and Asan Medical Center (AMC), 88 Olympic-Ro 43-Gil, Songpa-gu, Seoul, 05505, Republic of Korea.
Won J; School of Mechanical Engineering, Korea University, 145 Anam-Ro, Seongbuk-gu, Seoul, 02841, Republic of Korea.
Chung S; School of Mechanical Engineering, Korea University, 145 Anam-Ro, Seongbuk-gu, Seoul, 02841, Republic of Korea.
Pak JH; Department of Biochemistry, Asan Medical Institute of Convergence Science and Technology (AMIST), University of Ulsan College of Medicine and Asan Medical Center (AMC), 88 Olympic-Ro 43-Gil, Songpa-gu, Seoul, 05505, Republic of Korea. .
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Źródło:
Parasites & vectors [Parasit Vectors] 2024 Mar 22; Vol. 17 (1), pp. 151. Date of Electronic Publication: 2024 Mar 22.
Typ publikacji:
Journal Article
MeSH Terms:
Clonorchiasis*/metabolism
Clonorchis sinensis*/metabolism
Bile Duct Neoplasms*/metabolism
Bile Duct Neoplasms*/pathology
Humans ; Animals ; Mice ; Transforming Growth Factor beta1/genetics ; Transforming Growth Factor beta1/metabolism ; Interleukin-6/genetics ; Interleukin-6/metabolism ; Hepatic Stellate Cells/metabolism ; Fibrosis ; Bile Ducts, Intrahepatic ; Epithelial-Mesenchymal Transition
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Cancer-associated fibroblast-secreted FGF7 as an ovarian cancer progression promoter.
Autorzy:
Feng S; Department of Obstetrics and Gynaecology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, China.
Ding B; Department of Obstetrics and Gynaecology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, China.
Dai Z; State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing, China.
Yin H; Department of Obstetrics and Gynaecology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, China.
Ding Y; Department of Obstetrics and Gynaecology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, China.
Liu S; Department of Obstetrics and Gynaecology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, China.
Zhang K; Department of Obstetrics and Gynaecology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, China.
Lin H; Department of Clinical Science and Research, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, China. .
Xiao Z; State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing, China. .
Shen Y; Department of Obstetrics and Gynaecology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, China. .
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Źródło:
Journal of translational medicine [J Transl Med] 2024 Mar 15; Vol. 22 (1), pp. 280. Date of Electronic Publication: 2024 Mar 15.
Typ publikacji:
Journal Article
MeSH Terms:
Cancer-Associated Fibroblasts*/metabolism
Ovarian Neoplasms*/pathology
Humans ; Female ; Fibroblast Growth Factor 7/metabolism ; Fibroblast Growth Factor 7/pharmacology ; Cell Line, Tumor ; Signal Transduction ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; Epithelial-Mesenchymal Transition/genetics ; Cell Movement/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
PKM2 promotes lymphatic metastasis of hypopharyngeal carcinoma via regulating epithelial-mesenchymal transition: an experimental research.
Autorzy:
Zhou X; Department of Otolaryngology, The First Affiliated Hospital of Chongqing Medical University, 1 Youyi Road, Yuzhong District, Chongqing, 400016, China.; Department of Otolaryngology, Chongqing Traditional Chinese Medicine Hospital, Chongqing, China.
Li Y; Department of Otolaryngology, The First Affiliated Hospital of Chongqing Medical University, 1 Youyi Road, Yuzhong District, Chongqing, 400016, China.
Pan M; Department of Otolaryngology, The First Affiliated Hospital of Chongqing Medical University, 1 Youyi Road, Yuzhong District, Chongqing, 400016, China.
Lu T; Department of Otolaryngology, The First Affiliated Hospital of Chongqing Medical University, 1 Youyi Road, Yuzhong District, Chongqing, 400016, China.
Liu C; Department of Otolaryngology, The First Affiliated Hospital of Chongqing Medical University, 1 Youyi Road, Yuzhong District, Chongqing, 400016, China.
Wang Z; Department of Otolaryngology, The First Affiliated Hospital of Chongqing Medical University, 1 Youyi Road, Yuzhong District, Chongqing, 400016, China.
Tang F; Department of Otolaryngology, The First Affiliated Hospital of Chongqing Medical University, 1 Youyi Road, Yuzhong District, Chongqing, 400016, China.
Hu G; Department of Otolaryngology, The First Affiliated Hospital of Chongqing Medical University, 1 Youyi Road, Yuzhong District, Chongqing, 400016, China. .
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Źródło:
Diagnostic pathology [Diagn Pathol] 2024 Mar 02; Vol. 19 (1), pp. 48. Date of Electronic Publication: 2024 Mar 02.
Typ publikacji:
Journal Article
MeSH Terms:
Carcinoma*/genetics
Pyruvate Kinase*/metabolism
Hypopharyngeal Neoplasms*/metabolism
Hypopharyngeal Neoplasms*/pathology
Animals ; Humans ; Cell Line, Tumor ; Cell Movement ; Cell Proliferation ; Epithelial-Mesenchymal Transition ; Gene Expression Regulation, Neoplastic ; Lymphatic Metastasis/genetics ; Prognosis
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Tight junction protein cingulin variant is associated with cancer susceptibility by overexpressed IQGAP1 and Rac1-dependent epithelial-mesenchymal transition.
Autorzy:
Huang YT; Department of Pharmacology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.; Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Hsu YT; Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan.; Division of Hematology, Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Wu PY; Department of Obstetrics and Gynecology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Yeh YM; Department of Oncology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Lin PC; Department of Oncology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Hsu KF; Department of Obstetrics and Gynecology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Shen MR; Department of Pharmacology, College of Medicine, National Cheng Kung University, Tainan, Taiwan. .; Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan. .; Department of Obstetrics and Gynecology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan. .
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Źródło:
Journal of experimental & clinical cancer research : CR [J Exp Clin Cancer Res] 2024 Mar 01; Vol. 43 (1), pp. 65. Date of Electronic Publication: 2024 Mar 01.
Typ publikacji:
Journal Article
MeSH Terms:
Neoplasms*/genetics
Tight Junction Proteins*/metabolism
Animals ; Humans ; Mice ; Cell Movement ; Cytoskeletal Proteins/metabolism ; Epithelial-Mesenchymal Transition/genetics ; Proteomics ; rac1 GTP-Binding Protein/genetics ; rac1 GTP-Binding Protein/metabolism ; RNA, Small Interfering/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The role of pregnancy associated plasma protein-A in triple negative breast cancer: a promising target for achieving clinical benefits.
Autorzy:
Poddar A; Fiona Elsey Cancer Research Institute, Victoria, Australia.; Federation University, Victoria, Australia.; RMIT University, Victoria, Australia.
Ahmady F; Fiona Elsey Cancer Research Institute, Victoria, Australia.; Federation University, Victoria, Australia.
Rao SR; Fiona Elsey Cancer Research Institute, Victoria, Australia.; Adelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia.
Sharma R; Fiona Elsey Cancer Research Institute, Victoria, Australia.; Federation University, Victoria, Australia.
Kannourakis G; Fiona Elsey Cancer Research Institute, Victoria, Australia.; Federation University, Victoria, Australia.
Prithviraj P; Fiona Elsey Cancer Research Institute, Victoria, Australia.; Federation University, Victoria, Australia.
Jayachandran A; Fiona Elsey Cancer Research Institute, Victoria, Australia. .; Federation University, Victoria, Australia. .
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Źródło:
Journal of biomedical science [J Biomed Sci] 2024 Feb 23; Vol. 31 (1), pp. 23. Date of Electronic Publication: 2024 Feb 23.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Triple Negative Breast Neoplasms*/therapy
Triple Negative Breast Neoplasms*/metabolism
Triple Negative Breast Neoplasms*/pathology
Female ; Pregnancy ; Humans ; Pregnancy-Associated Plasma Protein-A/metabolism ; Cell Transformation, Neoplastic ; Epithelial-Mesenchymal Transition
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Stromal cartilage oligomeric matrix protein as a tumorigenic driver in ovarian cancer via Notch3 signaling and epithelial-to-mesenchymal transition.
Autorzy:
Gorji-Bahri, Gilar (AUTHOR)
Krishna, B. Madhu (AUTHOR)
Hagerling, Catharina (AUTHOR)
Orimo, Akira (AUTHOR)
Jirström, Karin (AUTHOR)
Papadakos, Konstantinos S. (AUTHOR)
Blom, Anna M. (AUTHOR)
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Źródło:
Journal of Translational Medicine. 4/13/2024, Vol. 22 Issue 1, p1-19. 19p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Elucidating the role of EPPK1 in lung adenocarcinoma development.
Autorzy:
Arimura, Ken (AUTHOR)
Kammer, Michael (AUTHOR)
Rahman, S. M. Jamshedur (AUTHOR)
Sheau-Chiann, Chen (AUTHOR)
Zhao, Shilin (AUTHOR)
Heidi, Chen (AUTHOR)
Eisenberg, Rosana (AUTHOR)
Zou, Yong (AUTHOR)
Antic, Sanja (AUTHOR)
Richmond, Bradley (AUTHOR)
Tagaya, Etsuko (AUTHOR)
Grogan, Eric (AUTHOR)
Massion, Pierre (AUTHOR)
Maldonado, Fabien (AUTHOR)
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Źródło:
BMC Cancer. 4/9/2024, Vol. 24 Issue 1, p1-13. 13p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Wyświetlanie 1-20 z 2553

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