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Tytuł:
Complex and variable regulation of ΔNp63 and TAp63 by TGFβ has implications for the dynamics of squamous cell epithelial to mesenchymal transition.
Autorzy:
Pokorná Z; Research Center of Applied Molecular Oncology (RECAMO), Masaryk Memorial Cancer Institute, Zluty Kopec 7, 656 53, Brno, Czech Republic.; State Institute for Drug Control, Šrobárova 48, 100 41, Praha 10, Czech Republic.
Tylichová Z; Research Center of Applied Molecular Oncology (RECAMO), Masaryk Memorial Cancer Institute, Zluty Kopec 7, 656 53, Brno, Czech Republic.
Vojtesek B; Research Center of Applied Molecular Oncology (RECAMO), Masaryk Memorial Cancer Institute, Zluty Kopec 7, 656 53, Brno, Czech Republic.
Coates PJ; Research Center of Applied Molecular Oncology (RECAMO), Masaryk Memorial Cancer Institute, Zluty Kopec 7, 656 53, Brno, Czech Republic. .
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Źródło:
Scientific reports [Sci Rep] 2024 Mar 27; Vol. 14 (1), pp. 7304. Date of Electronic Publication: 2024 Mar 27.
Typ publikacji:
Journal Article
MeSH Terms:
Epithelial-Mesenchymal Transition*/genetics
Carcinoma, Squamous Cell*/genetics
Carcinoma, Squamous Cell*/metabolism
Humans ; Transforming Growth Factor beta ; Epithelial Cells/metabolism ; Protein Isoforms/genetics ; Protein Isoforms/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Modelling bronchial epithelial-fibroblast cross-talk in idiopathic pulmonary fibrosis (IPF) using a human-derived in vitro air liquid interface (ALI) culture.
Autorzy:
Barron SL; Chemical Engineering and Biotechnology Department, University of Cambridge, Cambridge, UK. .
Wyatt O; Research and Early Development, Respiratory and Immunology, Bioscience Asthma and Skin Immunity, AstraZeneca, Cambridge, UK.
O'Connor A; Research and Early Development, Respiratory and Immunology, Bioscience Asthma and Skin Immunity, AstraZeneca, Cambridge, UK.
Mansfield D; Imaging and Data Analytics, Clinical Pharmacology and Safety Sciences, AstraZeneca, Cambridge, UK.
Suzanne Cohen E; Research and Early Development, Respiratory and Immunology, Bioscience Asthma and Skin Immunity, AstraZeneca, Cambridge, UK.
Witkos TM; Analytical Sciences, Bioassay, Biosafety and Impurities, BioPharmaceutical Development, AstraZeneca, Cambridge, UK.
Strickson S; Research and Early Development, Respiratory and Immunology, Bioscience Asthma and Skin Immunity, AstraZeneca, Cambridge, UK.
Owens RM; Chemical Engineering and Biotechnology Department, University of Cambridge, Cambridge, UK. .
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Źródło:
Scientific reports [Sci Rep] 2024 Jan 02; Vol. 14 (1), pp. 240. Date of Electronic Publication: 2024 Jan 02.
Typ publikacji:
Journal Article
MeSH Terms:
Epithelial-Mesenchymal Transition*/physiology
Idiopathic Pulmonary Fibrosis*/metabolism
Humans ; Fibroblasts/metabolism ; Transforming Growth Factor beta/metabolism ; RNA, Messenger/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Synthetic circuits based on split Cas9 to detect cellular events.
Autorzy:
Przybyszewska-Podstawka A; Department of Biochemistry and Molecular Biology, Medical University of Lublin, 20-093, Lublin, Poland.
Czapiński J; Department of Biochemistry and Molecular Biology, Medical University of Lublin, 20-093, Lublin, Poland.
Kałafut J; Department of Biochemistry and Molecular Biology, Medical University of Lublin, 20-093, Lublin, Poland.
Rivero-Müller A; Department of Biochemistry and Molecular Biology, Medical University of Lublin, 20-093, Lublin, Poland. .
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Źródło:
Scientific reports [Sci Rep] 2023 Sep 11; Vol. 13 (1), pp. 14988. Date of Electronic Publication: 2023 Sep 11.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Epithelial-Mesenchymal Transition*/genetics
CRISPR-Cas Systems*
Epithelial Cells ; Giant Cells ; Acclimatization
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The synergistic effect of EMT regulators and m6A modification on prognosis-related immunological signatures for ovarian cancer.
Autorzy:
Zhang Y; Department of Blood Transfusion, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 610072, People's Republic of China.
Wang X; Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, People's Republic of China.
Duan X; Chengdu Eighth People's Hospital/Geriatric Hospital of Chengdu Medical College, Chengdu, 610000, Sichuan, People's Republic of China.
Du T; Noncoding RNA and Drug Discovery Key Laboratory of Sichuan Province, Chengdu Medical College, Chengdu, 610000, Sichuan, People's Republic of China. .
Chen X; Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, People's Republic of China. .
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Źródło:
Scientific reports [Sci Rep] 2023 Sep 08; Vol. 13 (1), pp. 14872. Date of Electronic Publication: 2023 Sep 08.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Epithelial-Mesenchymal Transition*/genetics
Ovarian Neoplasms*/genetics
Female ; Humans ; Prognosis ; Adenosine ; Algorithms ; Cadherins ; Ubiquitin-Protein Ligases
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
MTAP-ANRIL gene fusion promotes melanoma epithelial-mesenchymal transition-like process by activating the JNK and p38 signaling pathways.
Autorzy:
Lin Z; Department of Gastroenterology, Shangrao People's Hospital, Shangrao, 334000, Jiangxi Province, China.
Lei Y; Department of Gastroenterology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei Province, China.; Institute of Liver and Gastrointestinal Diseases, Huazhong University of Science and Technology, Tongji Hospital of Tongji Medical CollegeWuhan, 430030, Hubei Province, China.
Wen M; Department of Otolaryngology-Head and Neck Surgery, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei Province, China.
He Q; Department of Gastroenterology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei Province, China.; Institute of Liver and Gastrointestinal Diseases, Huazhong University of Science and Technology, Tongji Hospital of Tongji Medical CollegeWuhan, 430030, Hubei Province, China.
Tian D; Department of Gastroenterology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei Province, China.; Institute of Liver and Gastrointestinal Diseases, Huazhong University of Science and Technology, Tongji Hospital of Tongji Medical CollegeWuhan, 430030, Hubei Province, China.
Xie H; Department of Gastroenterology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei Province, China. .; Institute of Liver and Gastrointestinal Diseases, Huazhong University of Science and Technology, Tongji Hospital of Tongji Medical CollegeWuhan, 430030, Hubei Province, China. .
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Źródło:
Scientific reports [Sci Rep] 2023 Jun 05; Vol. 13 (1), pp. 9073. Date of Electronic Publication: 2023 Jun 05.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Epithelial-Mesenchymal Transition*/genetics
Melanoma*/genetics
Melanoma*/pathology
Humans ; Signal Transduction ; Exons ; Gene Fusion
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Involvement of TGFBI-TAGLN axis in cancer stem cell property of head and neck squamous cell carcinoma.
Autorzy:
Sarubo M; Department of Oral Bioscience, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan.
Mouri Y; Department of Oral Bioscience, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan.
Moromizato A; Department of Oral Bioscience, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan.
Yamada A; Department of Oral Bioscience, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan.
Jin S; Department of Oral Bioscience, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan.
Shao W; Department of Oral Bioscience, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan.
Hagita H; Department of Oral Bioscience, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan.
Miyoshi K; Department of Oral Bioscience, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan.
Kudo Y; Department of Oral Bioscience, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan. .
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Źródło:
Scientific reports [Sci Rep] 2024 Mar 21; Vol. 14 (1), pp. 6767. Date of Electronic Publication: 2024 Mar 21.
Typ publikacji:
Journal Article
MeSH Terms:
Carcinoma, Squamous Cell*/pathology
Head and Neck Neoplasms*/pathology
Humans ; Squamous Cell Carcinoma of Head and Neck/pathology ; Cell Line, Tumor ; Neoplastic Stem Cells/metabolism ; Epithelial-Mesenchymal Transition/genetics ; RNA/metabolism ; Gene Expression Regulation, Neoplastic
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Adult skin fibroblast state change in murine wound healing.
Autorzy:
Gharbia FZ; Graduate Nanotechnology Program, The American University in Cairo (AUC), AUC Avenue, P.O. Box 74, New Cairo, 11835, Egypt.; Department of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, MI, 48105, USA.
Abouhashem AS; Indiana Center for Regenerative Medicine & Engineering, Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.; Department of Chemistry, School of Sciences & Engineering, The American University in Cairo (AUC), AUC Avenue, P.O. Box 74, New Cairo, 11835, Egypt.; Sharkia Clinical Research Department, Ministry of Health & Population, Zagazig, 44511, Sharkia, Egypt.; CytoTalk LLC, Cheyenne, WY, 82001, USA.
Moqidem YA; Department of Biology, School of Sciences & Engineering, The American University in Cairo (AUC), AUC Avenue, P.O. Box 74, New Cairo, 11835, Egypt.
Elbaz AA; Department of Chemistry, School of Sciences & Engineering, The American University in Cairo (AUC), AUC Avenue, P.O. Box 74, New Cairo, 11835, Egypt.; CytoTalk LLC, Cheyenne, WY, 82001, USA.
Abdellatif A; Department of Biology, School of Sciences & Engineering, The American University in Cairo (AUC), AUC Avenue, P.O. Box 74, New Cairo, 11835, Egypt.
Singh K; Indiana Center for Regenerative Medicine & Engineering, Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
Sen CK; Indiana Center for Regenerative Medicine & Engineering, Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, 46202, USA. .
Azzazy HME; Department of Chemistry, School of Sciences & Engineering, The American University in Cairo (AUC), AUC Avenue, P.O. Box 74, New Cairo, 11835, Egypt. .; Department of Nanobiophotonics, Leibniz Institute for Photonic Technology, Albert Einstein Str. 9, 07745, Jena, Germany. .
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Źródło:
Scientific reports [Sci Rep] 2023 Jan 17; Vol. 13 (1), pp. 886. Date of Electronic Publication: 2023 Jan 17.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Skin*/metabolism
Epithelial-Mesenchymal Transition*/genetics
Mice ; Animals ; Wound Healing/genetics ; Transcription Factors/metabolism ; Fibroblasts ; Neoplasm Proteins/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Kv3.4 regulates cell migration and invasion through TGF-β-induced epithelial-mesenchymal transition in A549 cells.
Autorzy:
Sim HJ; Laboratory of Veterinary Pharmacology, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826, Korea.
Kim MR; Laboratory of Veterinary Pharmacology, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826, Korea.
Song MS; Department of Physiology, College of Medicine, Gyeongsang National University, Jinju, 52727, Korea.
Lee SY; Laboratory of Veterinary Pharmacology, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826, Korea. .
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Źródło:
Scientific reports [Sci Rep] 2024 Jan 28; Vol. 14 (1), pp. 2309. Date of Electronic Publication: 2024 Jan 28.
Typ publikacji:
Journal Article
MeSH Terms:
Transforming Growth Factor beta*/pharmacology
Lung Neoplasms*/pathology
Humans ; A549 Cells ; Cell Line, Tumor ; Transforming Growth Factor beta1/pharmacology ; Epithelial-Mesenchymal Transition ; Cell Movement
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Mesenchymal-epithelial transition and AXL inhibitor TP-0903 sensitise triple-negative breast cancer cells to the antimalarial compound, artesunate.
Autorzy:
Terragno M; Department of Biomedical Sciences, School of Medicine, Nazarbayev University, Astana, Kazakhstan. .
Vetrova A; Department of Biomedical Sciences, School of Medicine, Nazarbayev University, Astana, Kazakhstan.
Semenov O; Regulation of Gene Expression Laboratory, Institute of Cytology RAS, Saint Petersburg, Russia.
Sayan AE; Cancer Sciences Division, University of Southampton, Southampton, UK.
Kriajevska M; Department of Biomedical Sciences, School of Medicine, Nazarbayev University, Astana, Kazakhstan.; Department of Genetics and Genome Biology, University of Leicester, Leicester, UK.
Tulchinsky E; Department of Biomedical Sciences, School of Medicine, Nazarbayev University, Astana, Kazakhstan. .; Department of Genetics and Genome Biology, University of Leicester, Leicester, UK. .
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Źródło:
Scientific reports [Sci Rep] 2024 Jan 03; Vol. 14 (1), pp. 425. Date of Electronic Publication: 2024 Jan 03.
Typ publikacji:
Journal Article
MeSH Terms:
Antimalarials*/pharmacology
Antimalarials*/therapeutic use
Triple Negative Breast Neoplasms*/drug therapy
Triple Negative Breast Neoplasms*/genetics
Triple Negative Breast Neoplasms*/pathology
Humans ; Artesunate/pharmacology ; Artesunate/therapeutic use ; Reactive Oxygen Species/pharmacology ; Epithelial-Mesenchymal Transition/genetics ; Cell Line, Tumor ; Cell Movement ; Cell Proliferation ; Peroxidases/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
H-NMR metabolomics analysis identifies hypoxanthine as a novel metastasis-associated metabolite in breast cancer.
Autorzy:
Shakartalla SB; Research Institute for Medical and Health Sciences, University of Sharjah, P.O. Box 27272, Sharjah, United Arab Emirates.; College of Medicine, University of Sharjah, P.O. Box 27272, Sharjah, United Arab Emirates.; Faculty of Pharmacy, University of Gezira, P.O. Box. 21111, Wadmedani, Sudan.
Ashmawy NS; Research Institute for Medical and Health Sciences, University of Sharjah, P.O. Box 27272, Sharjah, United Arab Emirates.; Department of Pharmaceutical Sciences, College of Pharmacy, Gulf Medical University, P.O. Box 4184, Ajman, United Arab Emirates.; Department of Pharmacognosy, Faculty of Pharmacy, Ain Shams University, Abbassia, P.O. Box 11566, Cairo, Egypt.
Semreen MH; Research Institute for Medical and Health Sciences, University of Sharjah, P.O. Box 27272, Sharjah, United Arab Emirates.; Department of Medicinal Chemistry, College of Pharmacy, University of Sharjah, P.O. Box 27272, Sharjah, United Arab Emirates.
Fayed B; Research Institute for Medical and Health Sciences, University of Sharjah, P.O. Box 27272, Sharjah, United Arab Emirates.; Chemistry of Natural and Microbial Product Department, National Research Centre, P.O. Box 12622, Cairo, Egypt.
Al Shareef ZM; College of Medicine, University of Sharjah, P.O. Box 27272, Sharjah, United Arab Emirates.
Jayakumar MN; Research Institute for Medical and Health Sciences, University of Sharjah, P.O. Box 27272, Sharjah, United Arab Emirates.
Ibrahim S; Research Institute for Medical and Health Sciences, University of Sharjah, P.O. Box 27272, Sharjah, United Arab Emirates.; Center for Biotechnology, Khalifa University, Abu Dhabi, United Arab Emirates.
Rahmani M; Research Institute for Medical and Health Sciences, University of Sharjah, P.O. Box 27272, Sharjah, United Arab Emirates.; Center for Biotechnology, Khalifa University, Abu Dhabi, United Arab Emirates.; College of Medicine and Health Sciences, Khalifa University, P.O. Box 127788, Abu Dhabi, United Arab Emirates.
Hamdy R; Research Institute for Medical and Health Sciences, University of Sharjah, P.O. Box 27272, Sharjah, United Arab Emirates.; Faculty of Pharmacy, Zagazig University, P.O. Box 44519, Zagazig, Egypt.
Soliman SSM; Research Institute for Medical and Health Sciences, University of Sharjah, P.O. Box 27272, Sharjah, United Arab Emirates. .; Department of Medicinal Chemistry, College of Pharmacy, University of Sharjah, P.O. Box 27272, Sharjah, United Arab Emirates. .
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Źródło:
Scientific reports [Sci Rep] 2024 Jan 02; Vol. 14 (1), pp. 253. Date of Electronic Publication: 2024 Jan 02.
Typ publikacji:
Journal Article
MeSH Terms:
Breast Neoplasms*/pathology
Female ; Humans ; Proton Magnetic Resonance Spectroscopy ; MCF-7 Cells ; Cell Line, Tumor ; Epithelial-Mesenchymal Transition/genetics ; Cell Movement ; Hypoxanthines/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Periostin facilitates ovarian cancer recurrence by enhancing cancer stemness.
Autorzy:
Huang Z; Division of Reproductive Sciences, Department of Obstetrics and Gynecology, Duke University School of Medicine, Durham, USA. .; Department of Obstetrics and Gynecology, Duke University Medical Center, 701 West Main Street, Suite 510, Duke, PO Box 90534, Durham, NC, 27701, USA. .
Byrd O; Division of Reproductive Sciences, Department of Obstetrics and Gynecology, Duke University School of Medicine, Durham, USA.
Tan S; Division of Reproductive Sciences, Department of Obstetrics and Gynecology, Duke University School of Medicine, Durham, USA.
Hu K; Division of Reproductive Sciences, Department of Obstetrics and Gynecology, Duke University School of Medicine, Durham, USA.
Knight B; Division of Reproductive Sciences, Department of Obstetrics and Gynecology, Duke University School of Medicine, Durham, USA.
Lo G; Division of Reproductive Sciences, Department of Obstetrics and Gynecology, Duke University School of Medicine, Durham, USA.
Taylor L; Division of Reproductive Sciences, Department of Obstetrics and Gynecology, Duke University School of Medicine, Durham, USA.
Wu Y; Biostatistics & Bioinformatics, Division of Biostatistics, Biostatistics & Bioinformatics, Duke University, Durham, USA.
Berchuck A; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Duke University School of Medicine, Durham, USA.
Murphy SK; Division of Reproductive Sciences, Department of Obstetrics and Gynecology, Duke University School of Medicine, Durham, USA.
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Źródło:
Scientific reports [Sci Rep] 2023 Dec 04; Vol. 13 (1), pp. 21382. Date of Electronic Publication: 2023 Dec 04.
Typ publikacji:
Journal Article
MeSH Terms:
Neoplasm Recurrence, Local*
Ovarian Neoplasms*/genetics
Cell Adhesion Molecules*/genetics
Animals ; Female ; Humans ; Mice ; Cell Line, Tumor ; Disease Progression ; Epithelial-Mesenchymal Transition/genetics ; Phenotype ; Tumor Microenvironment
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
EZH2 regulates oncomiR-200c and EMT markers in esophageal squamous cell carcinomas.
Autorzy:
Nourmohammadi F; Department of Biology, Damghan Branch, Islamic Azad University, Damghan, Iran.
Forghanifard MM; Department of Biology, Damghan Branch, Islamic Azad University, Damghan, Iran. .
Abbaszadegan MR; Medical Genetics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Zarrinpour V; Department of Biology, Damghan Branch, Islamic Azad University, Damghan, Iran.
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Źródło:
Scientific reports [Sci Rep] 2022 Oct 31; Vol. 12 (1), pp. 18290. Date of Electronic Publication: 2022 Oct 31.
Typ publikacji:
Journal Article
MeSH Terms:
Enhancer of Zeste Homolog 2 Protein*/genetics
Enhancer of Zeste Homolog 2 Protein*/metabolism
Epithelial-Mesenchymal Transition*/genetics
Esophageal Neoplasms*/pathology
Esophageal Squamous Cell Carcinoma*/genetics
MicroRNAs*/genetics
MicroRNAs*/metabolism
Humans ; Biomarkers ; Cell Line, Tumor ; Cell Movement/genetics ; Cell Proliferation/genetics ; Gene Expression Regulation, Neoplastic ; Neoplasm Invasiveness/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Lack of extracellular matrix switches TGF-β induced apoptosis of endometrial cells to epithelial to mesenchymal transition.
Autorzy:
Ruiz-Mitjana A; Oncologic Pathology Group, Departament de Ciències Mèdiques Bàsiques, Universitat de Lleida, Institut de Recerca Biomèdica de Lleida, IRBLleida, Ed Biomedicina I, Hospital Arnau de Vilanova, Av Rovira Roure, 80, 25198, Lleida, Spain.
Navaridas R; Oncologic Pathology Group, Departament de Ciències Mèdiques Bàsiques, Universitat de Lleida, Institut de Recerca Biomèdica de Lleida, IRBLleida, Ed Biomedicina I, Hospital Arnau de Vilanova, Av Rovira Roure, 80, 25198, Lleida, Spain.
Vidal-Sabanés M; Oncologic Pathology Group, Departament de Ciències Mèdiques Bàsiques, Universitat de Lleida, Institut de Recerca Biomèdica de Lleida, IRBLleida, Ed Biomedicina I, Hospital Arnau de Vilanova, Av Rovira Roure, 80, 25198, Lleida, Spain.
Perramon-Güell A; Oncologic Pathology Group, Departament de Ciències Mèdiques Bàsiques, Universitat de Lleida, Institut de Recerca Biomèdica de Lleida, IRBLleida, Ed Biomedicina I, Hospital Arnau de Vilanova, Av Rovira Roure, 80, 25198, Lleida, Spain.
Yeramian A; Oncologic Pathology Group, Departament de Ciències Mèdiques Bàsiques, Universitat de Lleida, Institut de Recerca Biomèdica de Lleida, IRBLleida, Ed Biomedicina I, Hospital Arnau de Vilanova, Av Rovira Roure, 80, 25198, Lleida, Spain.
Felip I; Oncologic Pathology Group, Departament de Ciències Mèdiques Bàsiques, Universitat de Lleida, Institut de Recerca Biomèdica de Lleida, IRBLleida, Ed Biomedicina I, Hospital Arnau de Vilanova, Av Rovira Roure, 80, 25198, Lleida, Spain.
Eritja N; Oncologic Pathology Group, Departament de Ciències Mèdiques Bàsiques, Universitat de Lleida, Institut de Recerca Biomèdica de Lleida, IRBLleida, Ed Biomedicina I, Hospital Arnau de Vilanova, Av Rovira Roure, 80, 25198, Lleida, Spain.
Egea J; Molecular Developmental Neurobiology Group, Departament de Ciències Mèdiques Bàsiques, Universitat de Lleida, Institut de Recerca Biomèdica de Lleida, IRBLleida, Lleida, Spain.
Encinas M; Developmental and Oncogenic Signaling Group, Departament de Medicina Experimental, Universitat de Lleida, Institut de Recerca Biomèdica de Lleida, IRBLleida, Lleida, Spain.
Matias-Guiu X; Oncologic Pathology Group, Departament de Ciències Mèdiques Bàsiques, Universitat de Lleida, Institut de Recerca Biomèdica de Lleida, IRBLleida, Ed Biomedicina I, Hospital Arnau de Vilanova, Av Rovira Roure, 80, 25198, Lleida, Spain.
Dolcet X; Oncologic Pathology Group, Departament de Ciències Mèdiques Bàsiques, Universitat de Lleida, Institut de Recerca Biomèdica de Lleida, IRBLleida, Ed Biomedicina I, Hospital Arnau de Vilanova, Av Rovira Roure, 80, 25198, Lleida, Spain. .
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Źródło:
Scientific reports [Sci Rep] 2022 Sep 01; Vol. 12 (1), pp. 14821. Date of Electronic Publication: 2022 Sep 01.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Epithelial-Mesenchymal Transition*
Extracellular Matrix*/metabolism
Transforming Growth Factor beta*/metabolism
Transforming Growth Factor beta*/pharmacology
Apoptosis/drug effects ; Carcinogenesis/metabolism ; Endometrium/metabolism ; Epithelial Cells ; Female ; Humans
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
TGFβ-induced changes in membrane curvature influence Ras oncoprotein membrane localization.
Autorzy:
Damalas A; Department of Chemistry, University of Copenhagen, Copenhagen, Denmark.; Fourth Department of Internal Medicine, School of Medicine, National and Kapodistrian University of Athens, Attikon University Hospital, 1st Rimini St, 12462, Haidari, Athens, Greece.
Vonkova I; Department of Chemistry, University of Copenhagen, Copenhagen, Denmark.; CZ-OPENSCREEN, Institute of Molecular Genetics of the Czech Academy of Sciences, Vídeňská 1083, 142 20, Prague, Czech Republic.
Tutkus M; Department of Chemistry, University of Copenhagen, Copenhagen, Denmark.; Institute of Biotechnology, Vilnius University, LT-10257, Vilnius, Lithuania.; Department of Molecular Compounds Physics, Center for Physical Sciences and Technology, LT-02300, Vilnius, Lithuania.
Stamou D; Department of Chemistry, University of Copenhagen, Copenhagen, Denmark. .
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Źródło:
Scientific reports [Sci Rep] 2022 Aug 05; Vol. 12 (1), pp. 13486. Date of Electronic Publication: 2022 Aug 05.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Epithelial-Mesenchymal Transition*
Transforming Growth Factor beta*/metabolism
Transforming Growth Factor beta*/pharmacology
Lipids ; Oncogene Proteins/metabolism ; Transforming Growth Factors/metabolism ; ras Proteins/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Mitochondrial dysfunction and epithelial to mesenchymal transition in head neck cancer cell lines.
Autorzy:
Greier MC; Department of Otorhinolaryngology, Head and Neck Surgery, Medical University of Innsbruck, Innsbruck, Austria.
Runge A; Department of Otorhinolaryngology, Head and Neck Surgery, Medical University of Innsbruck, Innsbruck, Austria. .
Dudas J; Department of Otorhinolaryngology, Head and Neck Surgery, Medical University of Innsbruck, Innsbruck, Austria.
Pider V; Department of Otorhinolaryngology, Head and Neck Surgery, Medical University of Innsbruck, Innsbruck, Austria.
Skvortsova II; Department of Therapeutic Radiology and Oncology, Medical University of Innsbruck, Innsbruck, Austria.; EXTRO-Lab, Tyrolean Cancer Research Institute, Department of Therapeutic Radiology and Oncology, Medical University of Innsbruck, Innsbruck, Austria.
Savic D; Department of Therapeutic Radiology and Oncology, Medical University of Innsbruck, Innsbruck, Austria.; EXTRO-Lab, Tyrolean Cancer Research Institute, Department of Therapeutic Radiology and Oncology, Medical University of Innsbruck, Innsbruck, Austria.
Riechelmann H; Department of Otorhinolaryngology, Head and Neck Surgery, Medical University of Innsbruck, Innsbruck, Austria.
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Źródło:
Scientific reports [Sci Rep] 2022 Aug 02; Vol. 12 (1), pp. 13255. Date of Electronic Publication: 2022 Aug 02.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Epithelial-Mesenchymal Transition*
Head and Neck Neoplasms*
Cadherins/metabolism ; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone/pharmacology ; Cell Line, Tumor ; Humans ; Keratins ; Mitochondria/metabolism ; Oligomycins/pharmacology ; Vimentin/metabolism
Czasopismo naukowe
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Tytuł:
Renal peritumoral adipose tissue undergoes a browning process and stimulates the expression of epithelial-mesenchymal transition markers in human renal cells.
Autorzy:
Ferrando M; Laboratory of Hormones and Cancer Biology, Centro Científico y Tecnológico Mendoza, Instituto de Medicina y Biología Experimental de Cuyo (IMBECU), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Universidad Nacional de Cuyo, Av. Ruiz Leal w/n, General San Martin Park, CP5500, Mendoza, Argentina.
Bruna FA; Laboratory of Hormones and Cancer Biology, Centro Científico y Tecnológico Mendoza, Instituto de Medicina y Biología Experimental de Cuyo (IMBECU), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Universidad Nacional de Cuyo, Av. Ruiz Leal w/n, General San Martin Park, CP5500, Mendoza, Argentina.; Facultad de Odontología, Centro de Investigaciones Odontológicas (CIO), Universidad Nacional de Cuyo, Mendoza, Argentina.
Romeo LR; Laboratory of Hormones and Cancer Biology, Centro Científico y Tecnológico Mendoza, Instituto de Medicina y Biología Experimental de Cuyo (IMBECU), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Universidad Nacional de Cuyo, Av. Ruiz Leal w/n, General San Martin Park, CP5500, Mendoza, Argentina.; Departamento de Urología y Trasplante Renal, Hospital Español de Mendoza, Mendoza, Argentina.
Contador D; Facultad de Medicina-Clínica Alemana, Centro de Medicina Regenerativa (CMR), Universidad del Desarrollo, Concepción, Chile.
Moya-Morales DL; Laboratory of Hormones and Cancer Biology, Centro Científico y Tecnológico Mendoza, Instituto de Medicina y Biología Experimental de Cuyo (IMBECU), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Universidad Nacional de Cuyo, Av. Ruiz Leal w/n, General San Martin Park, CP5500, Mendoza, Argentina.
Santiano F; Laboratory of Hormones and Cancer Biology, Centro Científico y Tecnológico Mendoza, Instituto de Medicina y Biología Experimental de Cuyo (IMBECU), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Universidad Nacional de Cuyo, Av. Ruiz Leal w/n, General San Martin Park, CP5500, Mendoza, Argentina.
Zyla L; Laboratory of Hormones and Cancer Biology, Centro Científico y Tecnológico Mendoza, Instituto de Medicina y Biología Experimental de Cuyo (IMBECU), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Universidad Nacional de Cuyo, Av. Ruiz Leal w/n, General San Martin Park, CP5500, Mendoza, Argentina.
Gomez S; Laboratory of Hormones and Cancer Biology, Centro Científico y Tecnológico Mendoza, Instituto de Medicina y Biología Experimental de Cuyo (IMBECU), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Universidad Nacional de Cuyo, Av. Ruiz Leal w/n, General San Martin Park, CP5500, Mendoza, Argentina.
Lopez-Fontana CM; Laboratory of Hormones and Cancer Biology, Centro Científico y Tecnológico Mendoza, Instituto de Medicina y Biología Experimental de Cuyo (IMBECU), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Universidad Nacional de Cuyo, Av. Ruiz Leal w/n, General San Martin Park, CP5500, Mendoza, Argentina.
Calvo JC; Instituto de Biología y Medicina Experimental (IBYME), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Mendoza, Argentina.; Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina.
Carón RW; Laboratory of Hormones and Cancer Biology, Centro Científico y Tecnológico Mendoza, Instituto de Medicina y Biología Experimental de Cuyo (IMBECU), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Universidad Nacional de Cuyo, Av. Ruiz Leal w/n, General San Martin Park, CP5500, Mendoza, Argentina.
Toneatto J; Instituto de Biología y Medicina Experimental (IBYME), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Mendoza, Argentina.
Pistone-Creydt V; Laboratory of Hormones and Cancer Biology, Centro Científico y Tecnológico Mendoza, Instituto de Medicina y Biología Experimental de Cuyo (IMBECU), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Universidad Nacional de Cuyo, Av. Ruiz Leal w/n, General San Martin Park, CP5500, Mendoza, Argentina. .; Departamento de Fisiología, Facultad de Ciencias Médicas, Universidad Nacional de Cuyo, Mendoza, Argentina. .
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Źródło:
Scientific reports [Sci Rep] 2022 May 23; Vol. 12 (1), pp. 8687. Date of Electronic Publication: 2022 May 23.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Epithelial-Mesenchymal Transition*
Kidney Neoplasms*/genetics
Kidney Neoplasms*/metabolism
Adipose Tissue/metabolism ; Adipose Tissue, Brown/metabolism ; Adipose Tissue, White/metabolism ; Cadherins/metabolism ; Humans
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Investigation of role of CpG methylation in some epithelial mesenchymal transition gene in a chemoresistant ovarian cancer cell line.
Autorzy:
Alghamian Y; Department of Animal Biology, Faculty of Sciences, Damascus University, Damascus, Syria.
Soukkarieh C; Department of Animal Biology, Faculty of Sciences, Damascus University, Damascus, Syria.
Abbady AQ; Human Genetics Division, Department of Molecular Biology and Biotechnology, Atomic Energy Commission of Syria (AECS), P.O. Box 6091, Damascus, Syria.
Murad H; Human Genetics Division, Department of Molecular Biology and Biotechnology, Atomic Energy Commission of Syria (AECS), P.O. Box 6091, Damascus, Syria. .
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Źródło:
Scientific reports [Sci Rep] 2022 May 06; Vol. 12 (1), pp. 7494. Date of Electronic Publication: 2022 May 06.
Typ publikacji:
Journal Article
MeSH Terms:
CpG Islands*
DNA Methylation*
Epithelial-Mesenchymal Transition*/genetics
Ovarian Neoplasms*/drug therapy
Ovarian Neoplasms*/genetics
Ovarian Neoplasms*/metabolism
Azacitidine/metabolism ; Cell Line, Tumor ; Cisplatin/therapeutic use ; Drug Resistance, Neoplasm/genetics ; Epithelial Cell Adhesion Molecule/metabolism ; Female ; Gene Expression Regulation, Neoplastic ; Humans
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
IL-8 is a novel prometastatic chemokine in intrahepatic cholangiocarcinoma that induces CXCR2-PI3K/AKT signaling upon CD97 activation.
Autorzy:
Meng ZW; Department of Hepatobiliary Surgery and Fujian Institute of Hepatobiliary Surgery, Fujian Medical University Union Hospital, Fujian Medical University Cancer Center, 29 Xinquan Road, Fuzhou, 350001, China.
Zhang L; Key Laboratory of Ministry of Education for Gastrointestinal Cancer, Fujian Medical University, 1 Xueyuan Road, Minhou, Fuzhou, 350108, China.; Fujian Key Laboratory of Tumor Microbiology, Fujian Medical University, 1 Xueyuan Road, Minhou, Fuzhou, 350108, China.
Cai XR; Department of Hepatobiliary Surgery and Fujian Institute of Hepatobiliary Surgery, Fujian Medical University Union Hospital, Fujian Medical University Cancer Center, 29 Xinquan Road, Fuzhou, 350001, China.
Wang X; Key Laboratory of Ministry of Education for Gastrointestinal Cancer, Fujian Medical University, 1 Xueyuan Road, Minhou, Fuzhou, 350108, China.; Fujian Key Laboratory of Tumor Microbiology, Fujian Medical University, 1 Xueyuan Road, Minhou, Fuzhou, 350108, China.
She FF; Key Laboratory of Ministry of Education for Gastrointestinal Cancer, Fujian Medical University, 1 Xueyuan Road, Minhou, Fuzhou, 350108, China. .; Fujian Key Laboratory of Tumor Microbiology, Fujian Medical University, 1 Xueyuan Road, Minhou, Fuzhou, 350108, China. .
Chen YL; Department of Hepatobiliary Surgery and Fujian Institute of Hepatobiliary Surgery, Fujian Medical University Union Hospital, Fujian Medical University Cancer Center, 29 Xinquan Road, Fuzhou, 350001, China. .
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Źródło:
Scientific reports [Sci Rep] 2023 Oct 31; Vol. 13 (1), pp. 18711. Date of Electronic Publication: 2023 Oct 31.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Bile Duct Neoplasms*/metabolism
Cholangiocarcinoma*/metabolism
Animals ; Mice ; Bile Ducts, Intrahepatic/pathology ; Cell Line, Tumor ; Cell Movement/physiology ; Epithelial-Mesenchymal Transition/physiology ; Interleukin-8 ; Mice, Nude ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Tumor Microenvironment ; Humans
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Identification and validation of novel prognostic signatures based on m5C methylation patterns and tumor EMT profiles in head and neck squamous cell carcinoma.
Autorzy:
Zhu G; Department of Otolaryngology Head and Neck Surgery, Shanghai Changhai Hospital, The Second Military Medical University, Shanghai, China.
Wang W; Department of Otolaryngology Head and Neck Surgery, Shanghai Changhai Hospital, The Second Military Medical University, Shanghai, China.
Yao H; Department of Otolaryngology Head and Neck Surgery, Shanghai Changhai Hospital, The Second Military Medical University, Shanghai, China.
Li H; Department of Otolaryngology Head and Neck Surgery, Shanghai Changhai Hospital, The Second Military Medical University, Shanghai, China.
Zhang C; Department of Otolaryngology Head and Neck Surgery, Shanghai Changhai Hospital, The Second Military Medical University, Shanghai, China.
Meng Y; Department of Otolaryngology Head and Neck Surgery, Shanghai Changhai Hospital, The Second Military Medical University, Shanghai, China.
Wang J; Department of Otolaryngology Head and Neck Surgery, Shanghai Changhai Hospital, The Second Military Medical University, Shanghai, China.
Zhu M; Department of Otolaryngology Head and Neck Surgery, Shanghai Changhai Hospital, The Second Military Medical University, Shanghai, China. .
Zheng H; Department of Otolaryngology Head and Neck Surgery, Shanghai Changhai Hospital, The Second Military Medical University, Shanghai, China. .
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Źródło:
Scientific reports [Sci Rep] 2023 Oct 31; Vol. 13 (1), pp. 18763. Date of Electronic Publication: 2023 Oct 31.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Head and Neck Neoplasms*/genetics
beta-Defensins*
Humans ; Squamous Cell Carcinoma of Head and Neck/genetics ; Prognosis ; Epithelial-Mesenchymal Transition/genetics ; Methylation ; Proteins
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Polygonum barbatum extract reduces colorectal cancer cell proliferation, migration, invasion, and epithelial-mesenchymal transition via YAP and β-catenin pathway regulation.
Autorzy:
Chang PK; Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan.; Division of Colon and Rectal Surgery, Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.; School of Medicine, National Defense Medical Center, Taipei, Taiwan.
Yen IC; School of Pharmacy, National Defense Medical Center, Taipei, Taiwan.
Tsai WC; Graduate Institute of Aerospace and Undersea Medicine, National Defense Medical Center, Taipei, Taiwan.
Lee SY; Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan. .; Graduate Institute of Aerospace and Undersea Medicine, National Defense Medical Center, Taipei, Taiwan. .
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Źródło:
Scientific reports [Sci Rep] 2023 Oct 26; Vol. 13 (1), pp. 18368. Date of Electronic Publication: 2023 Oct 26.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Colorectal Neoplasms*/drug therapy
Colorectal Neoplasms*/genetics
Colorectal Neoplasms*/metabolism
Polygonum*
Plant Extracts*/pharmacology
Humans ; beta Catenin/metabolism ; Cell Line, Tumor ; Cell Movement ; Cell Proliferation ; Epithelial-Mesenchymal Transition/genetics ; Gene Expression Regulation, Neoplastic
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
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