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Tytuł :
A budding yeast model for human disease mutations in the EXOSC2 cap subunit of the RNA exosome complex.
Autorzy :
Sterrett MC; Biochemistry, Cell and Developmental Biology Graduate Program, Emory University, Atlanta, Georgia 30322, USA.; Department of Biology, Emory University, Atlanta, Georgia 30322, USA.
Enyenihi L; Department of Biology, Emory University, Atlanta, Georgia 30322, USA.
Leung SW; Department of Biology, Emory University, Atlanta, Georgia 30322, USA.
Hess L; Department of Biology, Emory University, Atlanta, Georgia 30322, USA.
Strassler SE; Biochemistry, Cell and Developmental Biology Graduate Program, Emory University, Atlanta, Georgia 30322, USA.; Department of Biochemistry, Emory University, Atlanta, Georgia 30322, USA.
Farchi D; Department of Biology, Emory University, Atlanta, Georgia 30322, USA.
Lee RS; Department of Biology, Emory University, Atlanta, Georgia 30322, USA.
Withers ES; Department of Biology, Emory University, Atlanta, Georgia 30322, USA.
Kremsky I; Loma Linda University School of Medicine, Loma Linda, California 92350, USA.
Baker RE; Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA.
Basrai MA; Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.
van Hoof A; Department of Microbiology and Molecular Genetics, University of Texas Health Science Center at Houston, Houston, Texas 77030, USA.
Fasken MB; Department of Biology, Emory University, Atlanta, Georgia 30322, USA.
Corbett AH; Department of Biology, Emory University, Atlanta, Georgia 30322, USA.
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Źródło :
RNA (New York, N.Y.) [RNA] 2021 Sep; Vol. 27 (9), pp. 1046-1067. Date of Electronic Publication: 2021 Jun 23.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Mutation, Missense*
Exoribonucleases/*genetics
Exosome Multienzyme Ribonuclease Complex/*genetics
RNA, Fungal/*genetics
RNA-Binding Proteins/*genetics
Saccharomyces cerevisiae/*genetics
Saccharomyces cerevisiae Proteins/*genetics
Amino Acid Sequence ; Amino Acid Substitution ; Aspartic Acid/chemistry ; Aspartic Acid/metabolism ; Dwarfism/enzymology ; Dwarfism/genetics ; Dwarfism/pathology ; Exoribonucleases/chemistry ; Exoribonucleases/metabolism ; Exosome Multienzyme Ribonuclease Complex/chemistry ; Exosome Multienzyme Ribonuclease Complex/metabolism ; Facies ; Gene Expression ; Glycine/chemistry ; Glycine/metabolism ; Hearing Loss/enzymology ; Hearing Loss/genetics ; Hearing Loss/pathology ; Humans ; Models, Biological ; Models, Molecular ; Protein Conformation ; RNA, Fungal/chemistry ; RNA, Fungal/metabolism ; RNA-Binding Proteins/chemistry ; RNA-Binding Proteins/metabolism ; Retinitis Pigmentosa/enzymology ; Retinitis Pigmentosa/genetics ; Retinitis Pigmentosa/pathology ; Saccharomyces cerevisiae/enzymology ; Saccharomyces cerevisiae Proteins/chemistry ; Saccharomyces cerevisiae Proteins/metabolism ; Sequence Homology, Amino Acid ; Syndrome
Czasopismo naukowe
Tytuł :
RNA-regulatory exosome complex confers cellular survival to promote erythropoiesis.
Autorzy :
Mehta C; Department of Cell and Regenerative Biology, Wisconsin Blood Cancer Research Institute, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA.; Carbone Cancer Center, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA.
Fraga de Andrade I; Department of Cell and Regenerative Biology, Wisconsin Blood Cancer Research Institute, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA.; Carbone Cancer Center, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA.
Matson DR; Department of Cell and Regenerative Biology, Wisconsin Blood Cancer Research Institute, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA.; Carbone Cancer Center, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA.
Dewey CN; Department of Biostatistics and Medical Informatics, University of Wisconsin, Madison, WI 53705, USA.
Bresnick EH; Department of Cell and Regenerative Biology, Wisconsin Blood Cancer Research Institute, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA.; Carbone Cancer Center, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2021 Sep 20; Vol. 49 (16), pp. 9007-9025.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Erythropoiesis*
RNA Processing, Post-Transcriptional*
Exoribonucleases/*metabolism
Exosome Multienzyme Ribonuclease Complex/*metabolism
Exosomes/*metabolism
Animals ; Apoptosis ; Cells, Cultured ; DNA Breaks, Double-Stranded ; Erythroblasts/cytology ; Erythroblasts/metabolism ; Exoribonucleases/genetics ; Exosome Multienzyme Ribonuclease Complex/genetics ; Exosomes/genetics ; GATA1 Transcription Factor/metabolism ; Humans ; Loss of Function Mutation ; Mice ; Mice, Inbred C57BL ; Transcriptome
Czasopismo naukowe
Tytuł :
Substrate discrimination and quality control require each catalytic activity of TRAMP and the nuclear RNA exosome.
Autorzy :
Das M; Structural Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065.
Zattas D; Structural Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065.
Zinder JC; Structural Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065.; Tri-Institutional Training Program in Chemical Biology, Memorial Sloan Kettering Cancer Center, New York, NY 10065.
Wasmuth EV; Structural Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065.
Henri J; Structural Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065.
Lima CD; Structural Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065; .; HHMI, Memorial Sloan Kettering Cancer Center, New York, NY 10065.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2021 Apr 06; Vol. 118 (14).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
RNA Stability*
Exosome Multienzyme Ribonuclease Complex/*metabolism
Saccharomyces cerevisiae Proteins/*metabolism
DEAD-box RNA Helicases/genetics ; DEAD-box RNA Helicases/metabolism ; Exosome Multienzyme Ribonuclease Complex/genetics ; Exosomes/genetics ; Exosomes/metabolism ; Polyadenylation ; Saccharomyces cerevisiae ; Saccharomyces cerevisiae Proteins/genetics
Czasopismo naukowe
Tytuł :
Exosome component 1 cleaves single-stranded DNA and sensitizes human kidney renal clear cell carcinoma cells to poly(ADP-ribose) polymerase inhibitor.
Autorzy :
Liu Q; Institute of Cancer Stem Cell, DaLian Medical University, Dalian, China.
Xiao Q; Institute of Cancer Stem Cell, DaLian Medical University, Dalian, China.
Sun Z; Institute of Cancer Stem Cell, DaLian Medical University, Dalian, China.
Wang B; Department of General Surgery, Second Affiliated Hospital, DaLian Medical University, Dalian, China.
Wang L; Institute of Cancer Stem Cell, DaLian Medical University, Dalian, China.
Wang N; Institute of Cancer Stem Cell, DaLian Medical University, Dalian, China.
Wang K; Institute of Cancer Stem Cell, DaLian Medical University, Dalian, China.
Song C; Institute of Cancer Stem Cell, DaLian Medical University, Dalian, China.
Yang Q; Institute of Cancer Stem Cell, DaLian Medical University, Dalian, China.
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Źródło :
ELife [Elife] 2021 Jun 23; Vol. 10. Date of Electronic Publication: 2021 Jun 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Carcinoma, Renal Cell/*metabolism
DNA, Single-Stranded/*metabolism
Exosome Multienzyme Ribonuclease Complex/*genetics
Kidney Neoplasms/*metabolism
Poly(ADP-ribose) Polymerase Inhibitors/*metabolism
RNA-Binding Proteins/*genetics
Animals ; Exosome Multienzyme Ribonuclease Complex/metabolism ; Humans ; Mice ; Mice, Nude ; RNA-Binding Proteins/metabolism
Czasopismo naukowe
Tytuł :
Structure of the Maturing 90S Pre-ribosome in Association with the RNA Exosome.
Autorzy :
Lau B; Heidelberg University Biochemistry Center (BZH), Im Neuenheimer Feld 328, 69120 Heidelberg, Germany.
Cheng J; Gene Center, Department of Biochemistry and Center for Integrated Protein Science Munich (CiPSM), Ludwig-Maximilians-Universität München, Feodor-Lynen-Straße 25, 81377 Munich, Germany.
Flemming D; Heidelberg University Biochemistry Center (BZH), Im Neuenheimer Feld 328, 69120 Heidelberg, Germany.
La Venuta G; Heidelberg University Biochemistry Center (BZH), Im Neuenheimer Feld 328, 69120 Heidelberg, Germany.
Berninghausen O; Gene Center, Department of Biochemistry and Center for Integrated Protein Science Munich (CiPSM), Ludwig-Maximilians-Universität München, Feodor-Lynen-Straße 25, 81377 Munich, Germany.
Beckmann R; Gene Center, Department of Biochemistry and Center for Integrated Protein Science Munich (CiPSM), Ludwig-Maximilians-Universität München, Feodor-Lynen-Straße 25, 81377 Munich, Germany. Electronic address: .
Hurt E; Heidelberg University Biochemistry Center (BZH), Im Neuenheimer Feld 328, 69120 Heidelberg, Germany. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2021 Jan 21; Vol. 81 (2), pp. 293-303.e4. Date of Electronic Publication: 2020 Dec 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DEAD-box RNA Helicases/*chemistry
Endoribonucleases/*chemistry
Exonucleases/*chemistry
Exosome Multienzyme Ribonuclease Complex/*ultrastructure
RNA, Ribosomal, 18S/*chemistry
Ribosomes/*ultrastructure
Saccharomyces cerevisiae/*genetics
Saccharomyces cerevisiae Proteins/*chemistry
Binding Sites ; Cryoelectron Microscopy ; DEAD-box RNA Helicases/genetics ; DEAD-box RNA Helicases/metabolism ; Endoribonucleases/genetics ; Endoribonucleases/metabolism ; Exonucleases/genetics ; Exonucleases/metabolism ; Exosome Multienzyme Ribonuclease Complex/genetics ; Exosome Multienzyme Ribonuclease Complex/metabolism ; Models, Molecular ; Protein Binding ; Protein Biosynthesis ; Protein Conformation, alpha-Helical ; Protein Conformation, beta-Strand ; Protein Interaction Domains and Motifs ; RNA Stability ; RNA, Ribosomal, 18S/genetics ; RNA, Ribosomal, 18S/metabolism ; Ribosomes/genetics ; Ribosomes/metabolism ; Saccharomyces cerevisiae/metabolism ; Saccharomyces cerevisiae Proteins/genetics ; Saccharomyces cerevisiae Proteins/metabolism
Czasopismo naukowe
Tytuł :
Yeast RNA exosome activity is necessary for maintaining cell wall stability through proper protein glycosylation.
Autorzy :
Novačić A; Laboratory of Biochemistry, Department of Chemistry and Biochemistry, Faculty of Food Technology and Biotechnology, University of Zagreb, Zagreb, Croatia.
Beauvais V; Centre de Biophysique Moléculaire, UPR 4301 du CNRS, 45071 Orléans, France.
Oskomić M; Laboratory of Biochemistry, Department of Chemistry and Biochemistry, Faculty of Food Technology and Biotechnology, University of Zagreb, Zagreb, Croatia.
Štrbac L; Laboratory of Biochemistry, Department of Chemistry and Biochemistry, Faculty of Food Technology and Biotechnology, University of Zagreb, Zagreb, Croatia.
Dantec AL; Centre de Biophysique Moléculaire, UPR 4301 du CNRS, 45071 Orléans, France.
Rahmouni AR; Centre de Biophysique Moléculaire, UPR 4301 du CNRS, 45071 Orléans, France.
Stuparević I; Laboratory of Biochemistry, Department of Chemistry and Biochemistry, Faculty of Food Technology and Biotechnology, University of Zagreb, Zagreb, Croatia.
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Źródło :
Molecular biology of the cell [Mol Biol Cell] 2021 Mar 01; Vol. 32 (5), pp. 363-375. Date of Electronic Publication: 2021 Jan 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Exosome Multienzyme Ribonuclease Complex/*metabolism
Adaptor Proteins, Signal Transducing/metabolism ; Catalytic Domain ; Cell Wall/metabolism ; Cell Wall/physiology ; DNA-Binding Proteins/metabolism ; Exosome Multienzyme Ribonuclease Complex/genetics ; Exosomes/genetics ; Exosomes/metabolism ; Gene Expression ; Glycosylation ; Nuclear Proteins/metabolism ; RNA Stability ; RNA-Binding Proteins/metabolism ; Saccharomyces cerevisiae/metabolism ; Saccharomyces cerevisiae Proteins/metabolism
Czasopismo naukowe
Tytuł :
Noncoding RNA processing by DIS3 regulates chromosomal architecture and somatic hypermutation in B cells.
Autorzy :
Laffleur B; Department of Microbiology and Immunology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Lim J; Department of Microbiology and Immunology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.; Department of Pharmacy, School of Pharmacy, Jeonbuk National University, Jeonju, South Korea.
Zhang W; Department of Microbiology and Immunology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Chen Y; Division of Life Science, Department of Chemical and Biological Engineering, Center for Systems Biology and Human Health, and State Key Laboratory of Molecular Neuroscience, Hong Kong University of Science and Technology, Hong Kong, China.
Pefanis E; Department of Microbiology and Immunology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.; Regeneron Pharmaceuticals, Tarrytown, NY, USA.
Bizarro J; Department of Microbiology and Immunology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Batista CR; Department of Microbiology and Immunology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Wu L; Department of Microbiology and Immunology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Economides AN; Regeneron Pharmaceuticals, Tarrytown, NY, USA.
Wang J; Division of Life Science, Department of Chemical and Biological Engineering, Center for Systems Biology and Human Health, and State Key Laboratory of Molecular Neuroscience, Hong Kong University of Science and Technology, Hong Kong, China.
Basu U; Department of Microbiology and Immunology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA. .
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Źródło :
Nature genetics [Nat Genet] 2021 Feb; Vol. 53 (2), pp. 230-242. Date of Electronic Publication: 2021 Feb 01.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
B-Lymphocytes/*physiology
Exosome Multienzyme Ribonuclease Complex/*genetics
RNA, Untranslated/*genetics
Somatic Hypermutation, Immunoglobulin/*physiology
Animals ; B-Lymphocytes/drug effects ; CCCTC-Binding Factor/genetics ; CCCTC-Binding Factor/metabolism ; Cell Cycle Proteins/genetics ; Cell Cycle Proteins/metabolism ; Chromosomal Proteins, Non-Histone/metabolism ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; Embryonic Stem Cells/physiology ; Exosome Multienzyme Ribonuclease Complex/metabolism ; Exosomes/genetics ; Green Fluorescent Proteins/genetics ; Mice, Knockout ; Mice, Transgenic ; Mutation ; RNA Processing, Post-Transcriptional ; Recombination, Genetic ; Tamoxifen/pharmacology
Czasopismo naukowe
Tytuł :
Post-transcriptional control of cellular differentiation by the RNA exosome complex.
Autorzy :
Fraga de Andrade I; Wisconsin Blood Cancer Research Institute, Department of Cell and Regenerative Biology, Carbone Cancer Center, University of Wisconsin School of Medicine and Public Health, 1111 Highland Avenue, 4009 WIMR, Madison, WI 53705, USA.
Mehta C; Wisconsin Blood Cancer Research Institute, Department of Cell and Regenerative Biology, Carbone Cancer Center, University of Wisconsin School of Medicine and Public Health, 1111 Highland Avenue, 4009 WIMR, Madison, WI 53705, USA.
Bresnick EH; Wisconsin Blood Cancer Research Institute, Department of Cell and Regenerative Biology, Carbone Cancer Center, University of Wisconsin School of Medicine and Public Health, 1111 Highland Avenue, 4009 WIMR, Madison, WI 53705, USA.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2020 Dec 02; Vol. 48 (21), pp. 11913-11928.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Protein Processing, Post-Translational*
Chromatin/*chemistry
Erythrocytes/*metabolism
Exosome Multienzyme Ribonuclease Complex/*metabolism
RNA, Messenger/*genetics
RNA-Binding Proteins/*genetics
Animals ; Cell Differentiation ; Chromatin/metabolism ; Chromatin/ultrastructure ; DNA Repair ; Erythrocytes/ultrastructure ; Exosome Multienzyme Ribonuclease Complex/genetics ; Exosome Multienzyme Ribonuclease Complex/ultrastructure ; Genomic Instability ; Hematopoietic Stem Cells/metabolism ; Hematopoietic Stem Cells/ultrastructure ; Humans ; Mice ; Organ Specificity ; Protein Subunits/genetics ; Protein Subunits/metabolism ; RNA, Messenger/metabolism ; RNA-Binding Proteins/metabolism
Czasopismo naukowe
Tytuł :
Epidemiology, genetics and treatment of multiple myeloma and precursor diseases.
Autorzy :
Hemminki K; Biomedical Center, Faculty of Medicine, Charles University in Pilsen, Pilsen, Czech Republic.; Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Försti A; Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Heidelberg, Germany.
Houlston R; Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.
Sud A; Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.; The Department of Haemato-Oncology, The Royal Marsden Hospital NHS Foundation Trust, London, UK.
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Źródło :
International journal of cancer [Int J Cancer] 2021 Dec 15; Vol. 149 (12), pp. 1980-1996. Date of Electronic Publication: 2021 Aug 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Biomarkers, Tumor/*genetics
Immunotherapy/*methods
Multiple Myeloma/*epidemiology
Cyclin D1/genetics ; Exosome Multienzyme Ribonuclease Complex/genetics ; Genetic Predisposition to Disease ; Histone Demethylases/genetics ; Humans ; Multiple Myeloma/diagnosis ; Multiple Myeloma/genetics ; Multiple Myeloma/therapy ; Mutation ; Plasma Cells/immunology ; Plasma Cells/pathology ; Repressor Proteins/genetics ; Risk Factors ; Survival Rate ; Transcriptional Elongation Factors/genetics
Czasopismo naukowe
Tytuł :
The RNA exosome complex degrades expanded hexanucleotide repeat RNA in C9orf72 FTLD/ALS.
Autorzy :
Kawabe Y; Psychiatry, Graduate School of Medicine, Osaka University, Osaka, Japan.
Mori K; Psychiatry, Graduate School of Medicine, Osaka University, Osaka, Japan.
Yamashita T; Psychiatry, Graduate School of Medicine, Osaka University, Osaka, Japan.
Gotoh S; Psychiatry, Graduate School of Medicine, Osaka University, Osaka, Japan.
Ikeda M; Psychiatry, Graduate School of Medicine, Osaka University, Osaka, Japan.
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Źródło :
The EMBO journal [EMBO J] 2020 Oct 01; Vol. 39 (19), pp. e102700. Date of Electronic Publication: 2020 Aug 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
RNA Stability*
Repetitive Sequences, Nucleic Acid*
Amyotrophic Lateral Sclerosis/*metabolism
C9orf72 Protein/*metabolism
Exoribonucleases/*metabolism
Exosome Multienzyme Ribonuclease Complex/*metabolism
Frontotemporal Lobar Degeneration/*metabolism
RNA/*metabolism
Amyotrophic Lateral Sclerosis/genetics ; C9orf72 Protein/genetics ; Exoribonucleases/genetics ; Exosome Multienzyme Ribonuclease Complex/genetics ; Frontotemporal Lobar Degeneration/genetics ; HeLa Cells ; Humans ; RNA/genetics
Czasopismo naukowe
Tytuł :
Nucleolar localization of the yeast RNA exosome subunit Rrp44 hints at early pre-rRNA processing as its main function.
Autorzy :
Okuda EK; Department of Biochemistry, Institute of Chemistry, University of São Paulo, São Paulo, Brazil.
Gonzales-Zubiate FA; Department of Biochemistry, Institute of Chemistry, University of São Paulo, São Paulo, Brazil.
Gadal O; Laboratoire de Biologie Moléculaire Eucaryote, Centre de Biologie Intégrative (CBI), Université de Toulouse, CNRS, UPS, Toulouse, France.
Oliveira CC; Department of Biochemistry, Institute of Chemistry, University of São Paulo, São Paulo, Brazil .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2020 Aug 07; Vol. 295 (32), pp. 11195-11213. Date of Electronic Publication: 2020 Jun 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
RNA Processing, Post-Transcriptional*
Cell Nucleolus/*metabolism
Exosome Multienzyme Ribonuclease Complex/*metabolism
Exosomes/*metabolism
RNA Precursors/*metabolism
RNA, Fungal/*metabolism
RNA, Transfer/*metabolism
Saccharomyces cerevisiae/*metabolism
Saccharomyces cerevisiae Proteins/*metabolism
Amino Acid Sequence ; Exosome Multienzyme Ribonuclease Complex/chemistry ; Protein Transport ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae Proteins/chemistry ; Subcellular Fractions/metabolism
Czasopismo naukowe
Tytuł :
Regulation of the conserved 3'-5' exoribonuclease EXOSC10/Rrp6 during cell division, development and cancer.
Autorzy :
Stuparević I; Laboratory of Biochemistry, Department of Chemistry and Biochemistry, Faculty of Food Technology and Biotechnology, University of Zagreb, Zagreb, 10000, Croatia.
Novačić A; Laboratory of Biochemistry, Department of Chemistry and Biochemistry, Faculty of Food Technology and Biotechnology, University of Zagreb, Zagreb, 10000, Croatia.
Rahmouni AR; Centre de Biophysique Moléculaire, UPR4301 du CNRS, Orléans, 45071, France.
Fernandez A; Institut de Génétique Humaine, UMR 9002 CNRS, Montpellier, France.
Lamb N; Institut de Génétique Humaine, UMR 9002 CNRS, Montpellier, France.
Primig M; Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) - UMR_S 1085, Rennes, 35000, France.
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Źródło :
Biological reviews of the Cambridge Philosophical Society [Biol Rev Camb Philos Soc] 2021 Aug; Vol. 96 (4), pp. 1092-1113. Date of Electronic Publication: 2021 Feb 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Neoplasms*/genetics
Saccharomyces cerevisiae Proteins*
Cell Division ; Exoribonucleases/genetics ; Exosome Multienzyme Ribonuclease Complex/genetics ; Humans ; Saccharomyces cerevisiae
Czasopismo naukowe
Tytuł :
Exosomal miRNA profiling before and after surgery revealed potential diagnostic and prognostic markers for lung adenocarcinoma.
Autorzy :
Xue X; Department of Respiratory and Critical Care, Chinese PLA General Hospital, Beijing 100853, China.; Department of Respiratory and Critical Care, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China.
Wang C; Shanghai Institute of Advanced Immunochemical Studies, ShanghaiTech University, Shanghai 201210, China.
Xue Z; Department of Thoracic Surgery, Chinese PLA General Hospital, Beijing 100853, China.
Wen J; Department of Thoracic Surgery, Chinese PLA General Hospital, Beijing 100853, China.
Han J; Department of Radiology, The Third Affiliated Hospital of Chongqing Medical University, Chongqing 401120, China.
Ma X; School of Clinical Medicine, Weifang Medical University, Shandong 261042, China.
Zang X; Microbiology Department, Chinese PLA General Hospital, Beijing 100853, China.
Deng H; Department of Respiratory and Critical Care, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China.
Guo R; Department of Respiratory and Critical Care, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China.
Asuquo IP; Departments of Radiology, Jinzhou Medical University, Jinzhou 121001, China.
Qin C; Department of Respiratory and Critical Care, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China.
Wang H; Department of Respiratory and Critical Care, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China.
Gao Q; Tianjin Institute of Environmental and Operational Medicine, Tianjin 300050, China.
Liu S; Shanghai Institute of Advanced Immunochemical Studies, ShanghaiTech University, Shanghai 201210, China.
Wang J; Department of Respiratory and Critical Care, Chinese PLA General Hospital, Beijing 100853, China.
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Źródło :
Acta biochimica et biophysica Sinica [Acta Biochim Biophys Sin (Shanghai)] 2020 Mar 18; Vol. 52 (3), pp. 281-293.
Typ publikacji :
Journal Article
MeSH Terms :
Adenocarcinoma of Lung/*genetics
Exosome Multienzyme Ribonuclease Complex/*genetics
MicroRNAs/*genetics
Adenocarcinoma/pathology ; Adenocarcinoma of Lung/diagnosis ; Adenocarcinoma of Lung/mortality ; Adult ; Aged ; Biomarkers, Tumor/genetics ; Carcinoma, Non-Small-Cell Lung/genetics ; Exosome Multienzyme Ribonuclease Complex/blood ; Exosome Multienzyme Ribonuclease Complex/metabolism ; Exosomes/genetics ; Female ; Gene Expression Profiling/methods ; Gene Expression Regulation, Neoplastic/genetics ; Humans ; Kaplan-Meier Estimate ; Lung Neoplasms/pathology ; Male ; MicroRNAs/blood ; MicroRNAs/metabolism ; Middle Aged ; Prognosis ; ROC Curve
Czasopismo naukowe
Tytuł :
RNA exosome mutations in pontocerebellar hypoplasia alter ribosome biogenesis and p53 levels.
Autorzy :
Müller JS; Wellcome Trust Centre for Mitochondrial Research, Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, UK.; Department of Clinical Neurosciences, University of Cambridge School of Clinical Medicine, Cambridge, UK.
Burns DT; Wellcome Trust Centre for Mitochondrial Research, Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, UK.; Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.
Griffin H; Wellcome Trust Centre for Mitochondrial Research, Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, UK.
Wells GR; Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.
Zendah RA; Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.
Munro B; Wellcome Trust Centre for Mitochondrial Research, Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, UK.; Department of Clinical Neurosciences, University of Cambridge School of Clinical Medicine, Cambridge, UK.
Schneider C; Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.
Horvath R; Wellcome Trust Centre for Mitochondrial Research, Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, UK .; Department of Clinical Neurosciences, University of Cambridge School of Clinical Medicine, Cambridge, UK.
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Źródło :
Life science alliance [Life Sci Alliance] 2020 Jun 11; Vol. 3 (8). Date of Electronic Publication: 2020 Jun 11 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cerebellar Diseases/*genetics
Exosome Multienzyme Ribonuclease Complex/*genetics
Ribosomes/*metabolism
Adult ; Animals ; Cell Line, Tumor ; Cerebellar Diseases/physiopathology ; Exosome Multienzyme Ribonuclease Complex/metabolism ; Exosomes/genetics ; Female ; Homozygote ; Humans ; Male ; Mutation ; RNA-Binding Proteins/genetics ; RNA-Binding Proteins/metabolism ; Ribosomes/genetics ; Tumor Suppressor Protein p53/genetics ; Tumor Suppressor Protein p53/metabolism ; Zebrafish/genetics ; Zebrafish Proteins/genetics
SCR Disease Name :
Pontocerebellar Hypoplasia
Czasopismo naukowe
Tytuł :
EXOSC9 depletion attenuates P-body formation, stress resistance, and tumorigenicity of cancer cells.
Autorzy :
Yoshino S; Division of Molecular Pathology, the Institute of Medical Science, The University of Tokyo, Shirokanedai, Minato-ku, Tokyo, Japan.
Matsui Y; Biomedical and Health Informatics Unit, Department of Integrated Health Science, Nagoya University Graduate School of Medicine, Daiko-Minami, Higashi-ku, Nagoya, Aichi, Japan.
Fukui Y; Division of Cellular and Molecular Biology, the Institute of Medical Science, The University of Tokyo, Shirokanedai, Minato-ku, Tokyo, Japan.
Seki M; Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, the University of Tokyo, Chiba, Japan.
Yamaguchi K; Division of Clinical Genome Research, the Institute of Medical Science, The University of Tokyo, Shirokanedai, Minato-ku, Tokyo, Japan.
Kanamori A; Division of Cellular and Molecular Biology, the Institute of Medical Science, The University of Tokyo, Shirokanedai, Minato-ku, Tokyo, Japan.
Saitoh Y; Division of Cellular and Molecular Biology, the Institute of Medical Science, The University of Tokyo, Shirokanedai, Minato-ku, Tokyo, Japan.; Center for Medical Education, Teikyo University of Science, Senjusakuragi, Adachi-ku, Tokyo, Japan.
Shimamura T; Division of Systems Biology, Nagoya University Graduate School of Medicine, Tsurumai-cho, Nagoya, Japan.
Suzuki Y; Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, the University of Tokyo, Chiba, Japan.
Furukawa Y; Division of Clinical Genome Research, the Institute of Medical Science, The University of Tokyo, Shirokanedai, Minato-ku, Tokyo, Japan.
Kaneko S; Department of System Biology, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Takaramachi, Kanazawa, Ishikawa, Japan.
Seiki M; Division of Cancer Cell Research, the Institute of Medical Science, The University of Tokyo, Shirokanedai, Minato-ku, Tokyo, Japan.
Murakami Y; Division of Molecular Pathology, the Institute of Medical Science, The University of Tokyo, Shirokanedai, Minato-ku, Tokyo, Japan.
Inoue JI; Division of Cellular and Molecular Biology, the Institute of Medical Science, The University of Tokyo, Shirokanedai, Minato-ku, Tokyo, Japan.
Sakamoto T; Department of System Biology, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Takaramachi, Kanazawa, Ishikawa, Japan. .
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Źródło :
Scientific reports [Sci Rep] 2020 Jun 09; Vol. 10 (1), pp. 9275. Date of Electronic Publication: 2020 Jun 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Exosome Multienzyme Ribonuclease Complex/*metabolism
RNA-Binding Proteins/*metabolism
Stress, Physiological/*physiology
APOBEC-3G Deaminase/genetics ; APOBEC-3G Deaminase/metabolism ; Animals ; Binding Sites ; Cell Line, Tumor ; Cytoplasmic Structures/metabolism ; DNA Damage ; Endoplasmic Reticulum Stress ; Exosome Multienzyme Ribonuclease Complex/genetics ; Exosomes/genetics ; Exosomes/metabolism ; Female ; Humans ; Mice, Inbred BALB C ; Oxidative Stress ; RNA-Binding Proteins/genetics ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
EXOSC10 sculpts the transcriptome during the growth-to-maturation transition in mouse oocytes.
Autorzy :
Wu D; Laboratory of Cellular and Developmental Biology, NIDDK, National Institutes of Health, Bethesda, MD 20892, USA.
Dean J; Laboratory of Cellular and Developmental Biology, NIDDK, National Institutes of Health, Bethesda, MD 20892, USA.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2020 Jun 04; Vol. 48 (10), pp. 5349-5365.
Typ publikacji :
Journal Article; Research Support, N.I.H., Intramural
MeSH Terms :
Oogenesis*
Transcriptome*
Exoribonucleases/*physiology
Exosome Multienzyme Ribonuclease Complex/*physiology
Oocytes/*growth & development
Oocytes/*metabolism
Animals ; CDC2 Protein Kinase/metabolism ; Exoribonucleases/genetics ; Exosome Multienzyme Ribonuclease Complex/genetics ; Female ; Infertility, Female/genetics ; Intracellular Membranes/metabolism ; Mice ; Nuclear Lamina/metabolism ; Poly A ; RNA/metabolism ; RNA Precursors/metabolism ; RNA Processing, Post-Transcriptional ; RNA, Ribosomal/metabolism ; RNA-Seq
Czasopismo naukowe
Tytuł :
Exosomal miRNAs in osteoarthritis.
Autorzy :
Mihanfar A; Department of Biochemistry, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran.; Student Research Committee, Urmia University of Medical Sciences, Urmia, Iran.
Shakouri SK; Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran.
Khadem-Ansari MH; Department of Biochemistry, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran.
Fattahi A; Department of Reproductive Biology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences Tabriz, Tabriz, Iran.
Latifi Z; Stem Cell and Regenerative Medicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran.; Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran.
Nejabati HR; Stem Cell and Regenerative Medicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran. .; Department of Biochemistry and Clinical Laboratories, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. .; Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran. .; Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. .
Nouri M; Stem Cell and Regenerative Medicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran. .; Department of Reproductive Biology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences Tabriz, Tabriz, Iran. .; Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. .
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Źródło :
Molecular biology reports [Mol Biol Rep] 2020 Jun; Vol. 47 (6), pp. 4737-4748. Date of Electronic Publication: 2020 Apr 10.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Exosome Multienzyme Ribonuclease Complex/*genetics
MicroRNAs/*genetics
Osteoarthritis/*genetics
Exosome Multienzyme Ribonuclease Complex/physiology ; Exosomes/genetics ; Exosomes/metabolism ; Humans ; MicroRNAs/metabolism ; Osteoarthritis/physiopathology ; Osteoarthritis/therapy
Czasopismo naukowe
Tytuł :
Comprehensive analysis of dysregulated exosomal long non-coding RNA networks associated with arteriovenous malformations.
Autorzy :
Li X; Department of Interventional Therapy, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, No. 639 Zhi Zao Ju Rd, Shanghai 200011, Shanghai, People's Republic of China.
Gui Z; Department of Department of Oral & Cranio-maxillofacial Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, No. 639 Zhi Zao Ju Rd, Shanghai 200011, Shanghai, People's Republic of China.
Han Y; Department of Interventional Therapy, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, No. 639 Zhi Zao Ju Rd, Shanghai 200011, Shanghai, People's Republic of China.
Yang X; Department of Interventional Therapy, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, No. 639 Zhi Zao Ju Rd, Shanghai 200011, Shanghai, People's Republic of China.
Wang Z; Department of Interventional Therapy, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, No. 639 Zhi Zao Ju Rd, Shanghai 200011, Shanghai, People's Republic of China.
Zheng L; Department of Interventional Therapy, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, No. 639 Zhi Zao Ju Rd, Shanghai 200011, Shanghai, People's Republic of China.
Zhang L; Department of Interventional Therapy, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, No. 639 Zhi Zao Ju Rd, Shanghai 200011, Shanghai, People's Republic of China.
Wang D; Department of Interventional Therapy, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, No. 639 Zhi Zao Ju Rd, Shanghai 200011, Shanghai, People's Republic of China.
Fan X; Department of Interventional Therapy, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, No. 639 Zhi Zao Ju Rd, Shanghai 200011, Shanghai, People's Republic of China. Electronic address: .
Su L; Department of Interventional Therapy, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, No. 639 Zhi Zao Ju Rd, Shanghai 200011, Shanghai, People's Republic of China. Electronic address: .
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Źródło :
Gene [Gene] 2020 May 15; Vol. 738, pp. 144482. Date of Electronic Publication: 2020 Feb 19.
Typ publikacji :
Journal Article
MeSH Terms :
Arteriovenous Malformations/*genetics
Exosome Multienzyme Ribonuclease Complex/*genetics
RNA, Long Noncoding/*genetics
Adult ; China ; Computational Biology/methods ; Exosome Multienzyme Ribonuclease Complex/metabolism ; Exosomes/genetics ; Exosomes/metabolism ; Female ; Gene Expression Profiling/methods ; Gene Expression Regulation, Neoplastic/genetics ; Gene Ontology ; Gene Regulatory Networks/genetics ; Humans ; Male ; MicroRNAs/genetics ; MicroRNAs/metabolism ; RNA, Messenger/genetics ; Signal Transduction/genetics ; Transcriptome/genetics
Czasopismo naukowe
Tytuł :
Exonuclease domain mutants of yeast DIS3 display genome instability.
Autorzy :
Milbury KL; a Terry Fox Laboratory , British Columbia Cancer Agency , Vancouver , Canada.
Paul B; b Department of Cell Biology , University of Alberta , Edmonton , Canada.
Lari A; b Department of Cell Biology , University of Alberta , Edmonton , Canada.
Fowler C; a Terry Fox Laboratory , British Columbia Cancer Agency , Vancouver , Canada.
Montpetit B; b Department of Cell Biology , University of Alberta , Edmonton , Canada.; c Department of Viticulture and Enology , University of California , Davis , CA , USA.
Stirling PC; a Terry Fox Laboratory , British Columbia Cancer Agency , Vancouver , Canada.; d Department of Medical Genetics , University of British Columbia , Vancouver , BC , Canada.
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Źródło :
Nucleus (Austin, Tex.) [Nucleus] 2019 Dec; Vol. 10 (1), pp. 21-32.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Mutation*
Exonucleases/*genetics
Exosome Multienzyme Ribonuclease Complex/*chemistry
Exosome Multienzyme Ribonuclease Complex/*genetics
Genomic Instability/*genetics
Saccharomyces cerevisiae/*genetics
Saccharomyces cerevisiae Proteins/*chemistry
Saccharomyces cerevisiae Proteins/*genetics
Exonucleases/chemistry ; Exonucleases/metabolism ; Exosome Multienzyme Ribonuclease Complex/metabolism ; Protein Domains/genetics ; Saccharomyces cerevisiae/metabolism ; Saccharomyces cerevisiae Proteins/metabolism
Czasopismo naukowe
Tytuł :
Genetic and genomic studies of pathogenic EXOSC2 mutations in the newly described disease SHRF implicate the autophagy pathway in disease pathogenesis.
Autorzy :
Yang X; Department travellers of Pathology, Stanford School of Medicine, Stanford, CA 94305, USA.; Department of Dermatology, Stanford School of Medicine, Stanford, CA 94305, USA.; Program in Cancer Biology, Stanford School of Medicine, Stanford, CA 94305, USA.
Bayat V; Department travellers of Pathology, Stanford School of Medicine, Stanford, CA 94305, USA.
DiDonato N; Institute for Clinical Genetics, TU Dresden, Dresden, Germany.
Zhao Y; Department of Dermatology, Stanford School of Medicine, Stanford, CA 94305, USA.
Zarnegar B; Department of Dermatology, Stanford School of Medicine, Stanford, CA 94305, USA.
Siprashvili Z; Department of Dermatology, Stanford School of Medicine, Stanford, CA 94305, USA.
Lopez-Pajares V; Department of Dermatology, Stanford School of Medicine, Stanford, CA 94305, USA.
Sun T; Department of Genetics, Stanford School of Medicine, Stanford, CA 94305, USA.
Tao S; Department of Dermatology, Stanford School of Medicine, Stanford, CA 94305, USA.
Li C; School of Life Sciences, Peking University, Beijing 100871, China.
Rump A; Institute for Clinical Genetics, TU Dresden, Dresden, Germany.
Khavari P; Department of Dermatology, Stanford School of Medicine, Stanford, CA 94305, USA.; Program in Cancer Biology, Stanford School of Medicine, Stanford, CA 94305, USA.
Lu B; Department travellers of Pathology, Stanford School of Medicine, Stanford, CA 94305, USA.; Program in Cancer Biology, Stanford School of Medicine, Stanford, CA 94305, USA.
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Źródło :
Human molecular genetics [Hum Mol Genet] 2020 Mar 13; Vol. 29 (4), pp. 541-553.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Exosome Multienzyme Ribonuclease Complex/*genetics
RNA-Binding Proteins/*genetics
Animals ; Autophagy/genetics ; Disease Models, Animal ; Drosophila/genetics ; Dwarfism/genetics ; Exosome Multienzyme Ribonuclease Complex/metabolism ; Exosomes/metabolism ; Female ; Genomics/methods ; HEK293 Cells ; Hearing Loss/genetics ; Humans ; Male ; Mutation, Missense/genetics ; Phenotype ; RNA/metabolism ; RNA-Binding Proteins/metabolism ; Retinitis Pigmentosa/genetics ; Syndrome
Czasopismo naukowe

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