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Tytuł :
A hidden threshold in motor neuron gene networks revealed by modulation of miR-218 dose.
Autorzy :
Amin ND; Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA. Electronic address: .
Senturk G; Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.
Costaguta G; Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.
Driscoll S; Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.
O'Leary B; Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.
Bonanomi D; Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.
Pfaff SL; Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA. Electronic address: .
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Źródło :
Neuron [Neuron] 2021 Oct 20; Vol. 109 (20), pp. 3252-3267.e6. Date of Electronic Publication: 2021 Aug 26.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Gene Dosage*
Gene Regulatory Networks/*genetics
MicroRNAs/*genetics
Motor Neuron Disease/*genetics
Motor Neurons/*metabolism
Animals ; Mice ; Mice, Knockout ; Sequence Analysis, RNA ; Single-Cell Analysis
Czasopismo naukowe
Tytuł :
Whole genome copy number analyses reveal a highly aberrant genome in TP53 mutant lung adenocarcinoma tumors.
Autorzy :
Bjaanæs MM; Department of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital-The Norwegian Radium Hospital, Oslo, Norway. .; Department of Oncology, Oslo University Hospital, 4950 Nydalen, Oslo, Norway. .
Nilsen G; Department of Computer Science, University of Oslo, Oslo, Norway.; Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, Oslo, Norway.
Halvorsen AR; Department of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital-The Norwegian Radium Hospital, Oslo, Norway.
Russnes HG; Department of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital-The Norwegian Radium Hospital, Oslo, Norway.; Department of Pathology, Oslo University Hospital, Oslo, Norway.
Solberg S; Department of Cardiothoracic Surgery, Oslo University Hospital, Oslo, Norway.
Jørgensen L; Department of Cardiothoracic Surgery, Oslo University Hospital, Oslo, Norway.
Brustugun OT; Department of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital-The Norwegian Radium Hospital, Oslo, Norway.; Section of Oncology, Vestre Viken Hospital, Drammen, Norway.
Lingjærde OC; Department of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital-The Norwegian Radium Hospital, Oslo, Norway.; Department of Computer Science, University of Oslo, Oslo, Norway.; Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, Oslo, Norway.
Helland Å; Department of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital-The Norwegian Radium Hospital, Oslo, Norway.; Department of Oncology, Oslo University Hospital, 4950 Nydalen, Oslo, Norway.
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Źródło :
BMC cancer [BMC Cancer] 2021 Oct 09; Vol. 21 (1), pp. 1089. Date of Electronic Publication: 2021 Oct 09.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Dosage*
Genes, p53*
Adenocarcinoma of Lung/*genetics
Carcinoma, Non-Small-Cell Lung/*genetics
Lung Neoplasms/*genetics
Adenocarcinoma of Lung/pathology ; Alleles ; Carcinoma, Non-Small-Cell Lung/pathology ; Chromosomes, Human, Pair 7 ; Chromosomes, Human, Pair 9 ; Class I Phosphatidylinositol 3-Kinases/genetics ; DNA Copy Number Variations ; Ex-Smokers ; Female ; Gene Expression ; Genes, erbB-1/genetics ; Genes, ras/genetics ; Humans ; Lung Neoplasms/pathology ; Male ; Non-Smokers ; Polymorphism, Single Nucleotide ; Signal Transduction/genetics ; Smokers ; TOR Serine-Threonine Kinases/genetics
Czasopismo naukowe
Tytuł :
Cohesin Core Complex Gene Dosage Contributes to Germinal Center Derived Lymphoma Phenotypes and Outcomes.
Autorzy :
Rivas MA; Division of Hematology and Medical Oncology, Department of Medicine, Weill Cornell Medicine, New York, NY, United States.
Durmaz C; Graduate Program on Physiology, Biophysics & Systems Biology, Weill Cornell Medicine, New York, NY, United States.
Kloetgen A; Department of Computational Biology of Infection Research, Helmholtz Centre for Infection Research, Braunschweig, Germany.
Chin CR; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, United States.; The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Al-Saud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, United States.
Chen Z; Division of Biostatistics and Epidemiology, Department of Population Health Sciences, Weill Cornell Medical College, New York, NY, United States.
Bhinder B; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, United States.; The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Al-Saud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, United States.; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY, United States.
Koren A; Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY, United States.
Viny AD; Division of Hematology/Oncology, Department of Medicine, Columbia University Irving Medical Center, New York, NY, United States.; Columbia Stem Cell Initiative, Department of Genetics & Development, Columbia University, New York, NY, United States.
Scharer CD; Department of Microbiology and Immunology, School of Medicine, Emory University, Atlanta, GA, United States.
Boss JM; Department of Microbiology and Immunology, School of Medicine, Emory University, Atlanta, GA, United States.
Elemento O; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, United States.; The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Al-Saud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, United States.; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY, United States.
Mason CE; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, United States.; The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Al-Saud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, United States.; The WorldQuant Initiative for Quantitative Prediction, Weill Cornell Medicine, New York, NY, United States.; The Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, United States.
Melnick AM; Division of Hematology and Medical Oncology, Department of Medicine, Weill Cornell Medicine, New York, NY, United States.
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Źródło :
Frontiers in immunology [Front Immunol] 2021 Sep 21; Vol. 12, pp. 688493. Date of Electronic Publication: 2021 Sep 21 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Dosage*
Haploinsufficiency*
B-Lymphocytes/*immunology
Biomarkers, Tumor/*genetics
Cell Cycle Proteins/*genetics
Chondroitin Sulfate Proteoglycans/*genetics
Chromosomal Proteins, Non-Histone/*genetics
Germinal Center/*immunology
Lymphoma, Large B-Cell, Diffuse/*genetics
Plasma Cells/*immunology
Animals ; B-Lymphocytes/metabolism ; Biomarkers, Tumor/metabolism ; Cell Cycle Proteins/immunology ; Cell Cycle Proteins/metabolism ; Cell Differentiation ; Cells, Cultured ; Chondroitin Sulfate Proteoglycans/immunology ; Chondroitin Sulfate Proteoglycans/metabolism ; Chromosomal Proteins, Non-Histone/immunology ; Chromosomal Proteins, Non-Histone/metabolism ; Coculture Techniques ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; Databases, Genetic ; Dioxygenases/genetics ; Dioxygenases/metabolism ; Gene Expression Regulation, Neoplastic ; Genetic Predisposition to Disease ; Germinal Center/metabolism ; Histone-Lysine N-Methyltransferase/genetics ; Histone-Lysine N-Methyltransferase/metabolism ; Humans ; Lymphoma, Large B-Cell, Diffuse/immunology ; Lymphoma, Large B-Cell, Diffuse/metabolism ; Mice, Knockout ; Myeloid-Lymphoid Leukemia Protein/genetics ; Myeloid-Lymphoid Leukemia Protein/metabolism ; Phenotype ; Plasma Cells/metabolism ; Transcription, Genetic
Czasopismo naukowe
Tytuł :
The "Burkitt-like" immunophenotype and genotype is rarely encountered in diffuse large B cell lymphoma and high-grade B cell lymphoma, NOS.
Autorzy :
Hüttl KS; Department of Clinical Pathology, Robert-Bosch-Krankenhaus, Auerbachstrasse 110, 70376, Stuttgart, Germany.
Staiger AM; Department of Clinical Pathology, Robert-Bosch-Krankenhaus, Auerbachstrasse 110, 70376, Stuttgart, Germany.; Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart and University of Tuebingen, Stuttgart, Germany.
Richter J; Institute of Pathology, Hematopathology Section and Lymph Node Registry, Universitätsklinikum Schleswig-Holstein, Campus Kiel, Kiel, Germany.
Ott MM; Institute of Pathology, Marienhospital Stuttgart, Stuttgart, Germany.
Kalmbach S; Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart and University of Tuebingen, Stuttgart, Germany.
Klapper W; Institute of Pathology, Hematopathology Section and Lymph Node Registry, Universitätsklinikum Schleswig-Holstein, Campus Kiel, Kiel, Germany.
Biesdorf AS; Department of Clinical Pathology, Robert-Bosch-Krankenhaus, Auerbachstrasse 110, 70376, Stuttgart, Germany.
Trümper L; Department of Hematology and Oncology, Georg-August University Göttingen, Göttingen, Germany.
Rosenwald A; Institute of Pathology, Universität Würzburg and Comprehensive Cancer Center Mainfranken (CCCMF), Würzburg, Germany.
Ziepert M; Institute for Medical Informatics, Statistics and Epidemiology, University Leipzig, Leipzig, Germany.
Horn H; Department of Clinical Pathology, Robert-Bosch-Krankenhaus, Auerbachstrasse 110, 70376, Stuttgart, Germany.; Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart and University of Tuebingen, Stuttgart, Germany.
Ott G; Department of Clinical Pathology, Robert-Bosch-Krankenhaus, Auerbachstrasse 110, 70376, Stuttgart, Germany. .
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Źródło :
Virchows Archiv : an international journal of pathology [Virchows Arch] 2021 Sep; Vol. 479 (3), pp. 575-583. Date of Electronic Publication: 2021 Mar 02.
Typ publikacji :
Journal Article
MeSH Terms :
Biomarkers, Tumor*/analysis
Biomarkers, Tumor*/genetics
DNA Copy Number Variations*
Gene Dosage*
Mutation*
Burkitt Lymphoma/*genetics
Burkitt Lymphoma/*immunology
Lymphoma, Large B-Cell, Diffuse/*genetics
Lymphoma, Large B-Cell, Diffuse/*immunology
Antigens, CD20/analysis ; Burkitt Lymphoma/pathology ; DNA Mutational Analysis ; Genetic Predisposition to Disease ; High-Throughput Nucleotide Sequencing ; Humans ; Immunohistochemistry ; Immunophenotyping ; In Situ Hybridization, Fluorescence ; Lymphoma, Large B-Cell, Diffuse/pathology ; Neoplasm Grading ; Neprilysin/analysis ; Phenotype ; Proto-Oncogene Proteins c-bcl-2/analysis ; Proto-Oncogene Proteins c-bcl-2/genetics ; Proto-Oncogene Proteins c-bcl-6/analysis ; Proto-Oncogene Proteins c-bcl-6/genetics ; Proto-Oncogene Proteins c-myc/genetics ; Retrospective Studies
Czasopismo naukowe
Tytuł :
Copy number signatures predict chromothripsis and clinical outcomes in newly diagnosed multiple myeloma.
Autorzy :
Maclachlan KH; Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Rustad EH; Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Oslo, Norway.
Derkach A; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Zheng-Lin B; Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Yellapantula V; Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Diamond B; Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Myeloma Service, Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL, USA.
Hultcrantz M; Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Ziccheddu B; Myeloma Service, Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL, USA.; Department of Molecular Biotechnologies and Health Sciences, University of Turin, Turin, Italy.
Boyle EM; Myeloma Research Program, NYU Langone, Perlmutter Cancer Center, New York, NY, USA.
Blaney P; Myeloma Research Program, NYU Langone, Perlmutter Cancer Center, New York, NY, USA.
Bolli N; Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy.; Hematology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Zhang Y; Cytogenetics Laboratory, Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Dogan A; Hematopathology Service, Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Lesokhin AM; Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Department of Medicine, Weill Cornell Medical College, New York, NY, USA.
Morgan GJ; Myeloma Research Program, NYU Langone, Perlmutter Cancer Center, New York, NY, USA.
Landgren O; Myeloma Service, Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL, USA.
Maura F; Myeloma Service, Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Aug 27; Vol. 12 (1), pp. 5172. Date of Electronic Publication: 2021 Aug 27.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Chromothripsis*
Gene Dosage*
Multiple Myeloma/*genetics
Humans ; Multiple Myeloma/diagnosis ; Multiple Myeloma/mortality ; Prognosis ; Whole Exome Sequencing ; Whole Genome Sequencing
Czasopismo naukowe
Tytuł :
The Changes in the p53 Protein across the Animal Kingdom Point to Its Involvement in Longevity.
Autorzy :
Bartas M; Department of Biology and Ecology, Faculty of Science, University of Ostrava, 71000 Ostrava, Czech Republic.
Brázda V; Institute of Biophysics of the Czech Academy of Sciences, 61265 Brno, Czech Republic.
Volná A; Department of Physics, Faculty of Science, University of Ostrava, Chittussiho 10, 71000 Ostrava, Czech Republic.
Červeň J; Department of Biology and Ecology, Faculty of Science, University of Ostrava, 71000 Ostrava, Czech Republic.
Pečinka P; Department of Biology and Ecology, Faculty of Science, University of Ostrava, 71000 Ostrava, Czech Republic.
Zawacka-Pankau JE; Faculty of Chemistry, University of Warsaw, Pasteura 1, 02-093 Warsaw, Poland.; Center for Hematology and Regenerative Medicine, Department of Medicine, Huddinge, Karolinska Institute, SE 171-74 Stockholm, Sweden.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Aug 07; Vol. 22 (16). Date of Electronic Publication: 2021 Aug 07.
Typ publikacji :
Journal Article
MeSH Terms :
Databases, Genetic*
Gene Dosage*
Longevity*
Models, Molecular*
Animals ; Protein Domains ; Protein Structure, Secondary ; Species Specificity ; Tumor Suppressor Protein p53/chemistry ; Tumor Suppressor Protein p53/genetics ; Tumor Suppressor Protein p53/metabolism
Czasopismo naukowe
Tytuł :
Chromosome X aneusomy and androgen receptor gene copy number aberrations in apocrine carcinoma of the breast.
Autorzy :
Cremonini A; Anatomic Pathology Section, Department of Oncology, Bellaria Hospital, AUSL Bologna, Via Altura 3, 40139, Bologna, Italy.
Saragoni L; Pathology Unit, Morgagni-Pierantoni Hospital, Forlì, Italy.
Morandi L; Department of Biomedical and Neuromotor Sciences, Functional MR Unit, IRCCS Istituto delle Scienze Neurologiche di Bologna, University of Bologna, 40139, Bologna, Italy.
Corradini AG; Anatomic Pathology Section 'M. Malpighi' Department of Biomedical and Neuromotor Sciences, University of Bologna, 40139, Bologna, Italy.
Ravaioli C; Anatomic Pathology Section 'M. Malpighi' Department of Biomedical and Neuromotor Sciences, University of Bologna, 40139, Bologna, Italy.
Di Oto E; Laboratory of Molecular Pathology and Anatomic Pathology, S. Orsola Clinical Hospital, Viale Ercolani 4/2, 40138, Bologna, Italy.
Limarzi F; Pathology Unit, Morgagni-Pierantoni Hospital, Forlì, Italy.
Sanchez AM; Multidisciplinary Breast Center - Dipartimento Scienze della Salute della donna e del Bambino e di Sanità Pubblica, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168, Rome, Italy.
Cucchi MC; Unit of Breast Surgery, Department of Oncology, Bellaria Hospital, AUSL Bologna, 40139, Bologna, Italy.
Masetti R; Multidisciplinary Breast Center - Dipartimento Scienze della Salute della donna e del Bambino e di Sanità Pubblica, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168, Rome, Italy.
Quinn C; Department of Histopathology, St. Vincent's University Hospital, Dublin, Ireland.; School of Medicine, University College Dublin, Dublin, Ireland.
Foschini MP; Anatomic Pathology Section, Department of Oncology, Bellaria Hospital, AUSL Bologna, Via Altura 3, 40139, Bologna, Italy. .; Anatomic Pathology Section 'M. Malpighi' Department of Biomedical and Neuromotor Sciences, University of Bologna, 40139, Bologna, Italy. .
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Źródło :
Virchows Archiv : an international journal of pathology [Virchows Arch] 2021 Aug; Vol. 479 (2), pp. 345-354. Date of Electronic Publication: 2021 Feb 03.
Typ publikacji :
Journal Article; Multicenter Study
MeSH Terms :
Chromosomes, Human, X*
DNA Copy Number Variations*
Gene Dosage*
Sex Chromosome Aberrations*
Biomarkers, Tumor/*genetics
Breast Neoplasms/*genetics
Carcinoma/*genetics
Receptors, Androgen/*genetics
Aged ; Aged, 80 and over ; Breast Neoplasms/pathology ; Carcinoma/pathology ; Cell Differentiation ; DNA Methylation ; Female ; Gene Expression Regulation, Neoplastic ; Genetic Predisposition to Disease ; Humans ; Immunohistochemistry ; In Situ Hybridization, Fluorescence ; Ireland ; Italy ; Middle Aged ; Monosomy ; Phenotype
Czasopismo naukowe
Tytuł :
Genomic analysis of high copy-number sequences for the targeted detection of Listeria species using a flow-through surveillance system.
Autorzy :
Quiñones B; U.S. Department of Agriculture, Agricultural Research Service, Western Regional Research Center, Produce Safety and Microbiology Research Unit, Albany, CA, 94710, USA. .
Yambao JC; U.S. Department of Agriculture, Agricultural Research Service, Western Regional Research Center, Produce Safety and Microbiology Research Unit, Albany, CA, 94710, USA.
De Guzman VS; SnapDNA, Inc, Mountain View, CA, 94043, USA.
Lee BG; U.S. Department of Agriculture, Agricultural Research Service, Western Regional Research Center, Produce Safety and Microbiology Research Unit, Albany, CA, 94710, USA.
Medin DL; SnapDNA, Inc, Mountain View, CA, 94043, USA.
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Źródło :
Archives of microbiology [Arch Microbiol] 2021 Aug; Vol. 203 (6), pp. 3667-3682. Date of Electronic Publication: 2021 Jun 02.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Dosage*
Genome, Bacterial*
Listeria/*genetics
Listeria/*isolation & purification
Food Microbiology
Czasopismo naukowe
Tytuł :
Modest changes in Spi1 dosage reveal the potential for altered microglial function as seen in Alzheimer's disease.
Autorzy :
Jones RE; Division of Infection and Immunity, Cardiff University, Cardiff, UK.; UK Dementia Research Institute at Cardiff, Cardiff University, Hadyn Ellis Building, Maindy Road, Cardiff, CF24 4HQ, UK.
Andrews R; Division of Infection and Immunity, Cardiff University, Cardiff, UK.; Systems Immunity Research Institute, Cardiff University, Cardiff, UK.
Holmans P; Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK.
Hill M; UK Dementia Research Institute at Cardiff, Cardiff University, Hadyn Ellis Building, Maindy Road, Cardiff, CF24 4HQ, UK.
Taylor PR; Division of Infection and Immunity, Cardiff University, Cardiff, UK. .; UK Dementia Research Institute at Cardiff, Cardiff University, Hadyn Ellis Building, Maindy Road, Cardiff, CF24 4HQ, UK. .; Systems Immunity Research Institute, Cardiff University, Cardiff, UK. .
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Źródło :
Scientific reports [Sci Rep] 2021 Jul 22; Vol. 11 (1), pp. 14935. Date of Electronic Publication: 2021 Jul 22.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Dosage*
Gene Regulatory Networks*
Alzheimer Disease/*genetics
Gene Expression Profiling/*methods
Microglia/*cytology
Proto-Oncogene Proteins/*genetics
Trans-Activators/*genetics
Animals ; Humans ; Interferons/metabolism ; Mice ; Microglia/metabolism ; Polymorphism, Single Nucleotide ; Primary Cell Culture ; Sequence Analysis, RNA ; Signal Transduction
Czasopismo naukowe
Tytuł :
Identification of pan-cancer Ras pathway activation with deep learning.
Autorzy :
Li X; School of Artificial Intelligence, Jilin University.
Li S; School of Computer Science, Northeast Normal University.
Wang Y; School of Computer Science, Northeast Normal University.
Zhang S; Department of Computer science, City University of Hong Kong, Hong Kong SAR.
Wong KC; Department of Computer science, City University of Hong Kong, Hong Kong SAR.
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Źródło :
Briefings in bioinformatics [Brief Bioinform] 2021 Jul 20; Vol. 22 (4).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Deep Learning*
Gene Dosage*
Neoplasm Proteins*/genetics
Neoplasm Proteins*/metabolism
Neoplasms*/epidemiology
Neoplasms*/genetics
Programming Languages*
ras Proteins*/genetics
ras Proteins*/metabolism
Signal Transduction/*genetics
Humans ; Mutation ; RNA-Seq
Czasopismo naukowe
Tytuł :
A synthetic circuit for buffering gene dosage variation between individual mammalian cells.
Autorzy :
Yang J; Department of Bioengineering, Rice University, Houston, TX, USA.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
Lee J; Systems, Synthetic, and Physical Biology Program, Rice University, Houston, TX, USA.
Land MA; Department of Neuroscience, Baylor College of Medicine, Houston, TX, USA.
Lai S; Department of Neuroscience, Baylor College of Medicine, Houston, TX, USA.
Igoshin OA; Department of Bioengineering, Rice University, Houston, TX, USA.; Systems, Synthetic, and Physical Biology Program, Rice University, Houston, TX, USA.; Department of Biosciences, Rice University, Houston, TX, USA.; Department of Chemistry, Rice University, Houston, TX, USA.
St-Pierre F; Systems, Synthetic, and Physical Biology Program, Rice University, Houston, TX, USA. .; Department of Neuroscience, Baylor College of Medicine, Houston, TX, USA. .; Department of Electrical and Computer Engineering, Rice University, Houston, TX, USA. .; Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Jul 05; Vol. 12 (1), pp. 4132. Date of Electronic Publication: 2021 Jul 05.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
DNA Copy Number Variations*
Gene Dosage*
Gene Expression Regulation*
Animals ; Cell Line ; Gene Expression ; MicroRNAs ; Plasmids ; Transfection
Czasopismo naukowe
Tytuł :
Probing low-copy-number proteins in single living cells using single-cell plasmonic immunosandwich assays.
Autorzy :
Liu J; State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, China.
He H; State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, China.
Xie D; State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, China.
Wen Y; State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, China.
Liu Z; State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, China. .
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Źródło :
Nature protocols [Nat Protoc] 2021 Jul; Vol. 16 (7), pp. 3522-3546. Date of Electronic Publication: 2021 Jun 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Dosage*
Single-Cell Analysis*
Immunoassay/*methods
Proteins/*metabolism
Antibodies/metabolism ; Calibration ; Cell Line, Tumor ; Cell Survival ; Data Analysis ; Gold/chemistry ; Humans ; Immobilized Proteins/metabolism ; Metal Nanoparticles/chemistry ; Metal Nanoparticles/ultrastructure ; Staining and Labeling
Czasopismo naukowe
Tytuł :
Stability of EPSPS gene copy number in Hordeum glaucum Steud (barley grass) in the presence and absence of glyphosate selection.
Autorzy :
Adu-Yeboah P; School of Agriculture Food and Wine, University of Adelaide, Glen Osmond, Australia.
Malone JM; School of Agriculture Food and Wine, University of Adelaide, Glen Osmond, Australia.
Gill G; School of Agriculture Food and Wine, University of Adelaide, Glen Osmond, Australia.
Preston C; School of Agriculture Food and Wine, University of Adelaide, Glen Osmond, Australia.
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Źródło :
Pest management science [Pest Manag Sci] 2021 Jul; Vol. 77 (7), pp. 3080-3087. Date of Electronic Publication: 2021 Apr 01.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Dosage*
Herbicides*/pharmacology
Hordeum*/enzymology
Hordeum*/genetics
3-Phosphoshikimate 1-Carboxyvinyltransferase/*genetics
Glycine/analogs & derivatives ; Herbicide Resistance/genetics ; Phosphates ; South Australia
Czasopismo naukowe
Tytuł :
A workflow for simultaneous DNA copy number and methylome analysis of inner cell mass and trophectoderm cells from human blastocysts.
Autorzy :
Olcha M; Department of Obstetrics and Gynecology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, New York. Electronic address: .
Dong X; Department of Genetics, Albert Einstein College of Medicine, Bronx, New York.
Feil H; Department of Obstetrics and Gynecology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, New York.
Hao X; Department of Genetics, Albert Einstein College of Medicine, Bronx, New York.
Lee M; Department of Genetics, Albert Einstein College of Medicine, Bronx, New York.
Jindal S; Department of Obstetrics and Gynecology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, New York.
Buyuk E; Department of Obstetrics and Gynecology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, New York; Reproductive Medicine Associates of New York, Division of Reproductive Endocrinology and Infertility, Department of Obstetrics, Gynecology, and Reproductive Science, Icahn School of Medicine at Mount Sinai, New York, New York.
Vijg J; Department of Genetics, Albert Einstein College of Medicine, Bronx, New York; Center for Single-Cell Omics in Aging and Disease, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.
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Źródło :
Fertility and sterility [Fertil Steril] 2021 Jun; Vol. 115 (6), pp. 1533-1540. Date of Electronic Publication: 2021 Feb 12.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Copy Number Variations*
DNA Methylation*
Epigenesis, Genetic*
Epigenome*
Epigenomics*
Gene Dosage*
Single-Cell Analysis*
Blastocyst Inner Cell Mass/*pathology
Trophoblasts/*pathology
Aneuploidy ; Blastocyst Inner Cell Mass/metabolism ; Cell Separation ; CpG Islands ; Female ; Gene Expression Regulation, Developmental ; Humans ; Trophoblasts/metabolism ; Whole Genome Sequencing ; Workflow
Czasopismo naukowe
Tytuł :
Reduced odds of diabetes associated with high plasma salivary α-amylase activity in Qatari women: a cross-sectional study.
Autorzy :
Al-Akl NS; Diabetes Research Center, Qatar Biomedical Research Institute (QBRI), Qatar Foundation, Hamad Bin Khalifa University (HBKU), PO Box: 34110, Doha, Qatar.
Thompson RI; Diabetes Research Center, Qatar Biomedical Research Institute (QBRI), Qatar Foundation, Hamad Bin Khalifa University (HBKU), PO Box: 34110, Doha, Qatar.
Arredouani A; Diabetes Research Center, Qatar Biomedical Research Institute (QBRI), Qatar Foundation, Hamad Bin Khalifa University (HBKU), PO Box: 34110, Doha, Qatar. .; College of Health and Life Sciences, Qatar Foundation, Hamad Bin Khalifa University (HBKU), Doha, Qatar. .
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Źródło :
Scientific reports [Sci Rep] 2021 Jun 01; Vol. 11 (1), pp. 11495. Date of Electronic Publication: 2021 Jun 01.
Typ publikacji :
Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Dosage*
Sex Characteristics*
Diabetes Mellitus/*blood
Salivary alpha-Amylases/*blood
Adult ; Diabetes Mellitus/epidemiology ; Diabetes Mellitus/genetics ; Female ; Humans ; Male ; Middle Aged ; Prevalence ; Qatar/epidemiology ; Salivary alpha-Amylases/genetics
Czasopismo naukowe
Tytuł :
Expanding Our Understanding of Nevogenesis: Copy Number Gain of Chromosome 15q in Melanocytic Nevi Is Associated With Distinct Histomorphologic Findings.
Autorzy :
Olson LC; Department of Pathology and Laboratory Medicine, Dartmouth-Hitchcock Medical Center, Lebanon.
Lefferts JA; Department of Pathology and Laboratory Medicine, Dartmouth-Hitchcock Medical Center, Lebanon.; Geisel School of Medicine at Dartmouth, Hanover, NH.
LeBlanc RE; Department of Pathology and Laboratory Medicine, Dartmouth-Hitchcock Medical Center, Lebanon.; Geisel School of Medicine at Dartmouth, Hanover, NH.
Yan S; Department of Pathology and Laboratory Medicine, Dartmouth-Hitchcock Medical Center, Lebanon.; Geisel School of Medicine at Dartmouth, Hanover, NH.
Momtahen S; Department of Pathology and Laboratory Medicine, Dartmouth-Hitchcock Medical Center, Lebanon.; Geisel School of Medicine at Dartmouth, Hanover, NH.
Sriharan A; Department of Pathology and Laboratory Medicine, Dartmouth-Hitchcock Medical Center, Lebanon.; Geisel School of Medicine at Dartmouth, Hanover, NH.
Linos K; Department of Pathology and Laboratory Medicine, Dartmouth-Hitchcock Medical Center, Lebanon.; Geisel School of Medicine at Dartmouth, Hanover, NH.
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Źródło :
The American journal of surgical pathology [Am J Surg Pathol] 2021 Jun 01; Vol. 45 (6), pp. 825-831.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Chromosomes, Human, Pair 15*
DNA Copy Number Variations*
Gene Dosage*
Nevus, Pigmented/*genetics
Skin Neoplasms/*genetics
Adult ; Aged ; Comparative Genomic Hybridization ; Female ; Genetic Predisposition to Disease ; Humans ; Male ; Middle Aged ; Nevus, Pigmented/pathology ; Oligonucleotide Array Sequence Analysis ; Phenotype ; Polymorphism, Single Nucleotide ; Skin Neoplasms/pathology
Czasopismo naukowe
Tytuł :
Dlk1 dosage regulates hippocampal neurogenesis and cognition.
Autorzy :
Montalbán-Loro R; ERI Biotecmed-Departamento de Biología Celular, Universidad de Valencia, 46010 Valencia,Spain.
Lassi G; Genetics and Epigenetics of Behaviour (GEB) Laboratory, Istituto Italiano di Tecnologia, 16163 Genova, Italy.; Translational Science and Experimental Medicine Research and Early Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge Biomedical Campus, Cambridge CB2 0AA, United Kingdom.
Lozano-Ureña A; ERI Biotecmed-Departamento de Biología Celular, Universidad de Valencia, 46010 Valencia,Spain.
Perez-Villalba A; ERI Biotecmed-Departamento de Biología Celular, Universidad de Valencia, 46010 Valencia,Spain.; Faculty of Psychology, Laboratory of Animal Behavior Phenotype (LABP), Universidad Católica de Valencia, 46100 Valencia, Spain.
Jiménez-Villalba E; ERI Biotecmed-Departamento de Biología Celular, Universidad de Valencia, 46010 Valencia,Spain.
Charalambous M; Department of Genetics, University of Cambridge, Cambridge CB2 3EH, United Kingdom.
Vallortigara G; Center for Mind/Brain Sciences, University of Trento, 38068 Rovereto TN, Italy.
Horner AE; Synome Ltd, Babraham, Cambridge CB22 3AT, United Kingdom.
Saksida LM; Department of Psychology, Medical Research Council and Wellcome Trust Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge CB2 3EB, United Kingdom.; Molecular Medicine Research Laboratories, Robarts Research Institute, Schulich School of Medicine and Dentistry, Western University, London, ON N6A 5K8, Canada.; Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, Western University, London, ON N6A 5C1, Canada.; The Brain and Mind Institute, Western University, London, ON N6A 5B7, Canada.
Bussey TJ; Department of Psychology, Medical Research Council and Wellcome Trust Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge CB2 3EB, United Kingdom.; Molecular Medicine Research Laboratories, Robarts Research Institute, Schulich School of Medicine and Dentistry, Western University, London, ON N6A 5K8, Canada.; Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, Western University, London, ON N6A 5C1, Canada.; The Brain and Mind Institute, Western University, London, ON N6A 5B7, Canada.
Trejo JL; Department of Translational Neuroscience, Cajal Institute, The Spanish National Research Council, Madrid 28002, Spain.
Tucci V; Genetics and Epigenetics of Behaviour (GEB) Laboratory, Istituto Italiano di Tecnologia, 16163 Genova, Italy.
Ferguson-Smith AC; Department of Genetics, University of Cambridge, Cambridge CB2 3EH, United Kingdom; .
Ferrón SR; ERI Biotecmed-Departamento de Biología Celular, Universidad de Valencia, 46010 Valencia,Spain; .
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2021 Mar 16; Vol. 118 (11).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Dosage*
Calcium-Binding Proteins/*genetics
Cognition/*physiology
Neurogenesis/*physiology
Alleles ; Animals ; Calcium-Binding Proteins/physiology ; Hippocampus/metabolism ; Mice
Czasopismo naukowe
Tytuł :
Gene dosage compensation of rRNA transcript levels in Arabidopsis thaliana lines with reduced ribosomal gene copy number.
Autorzy :
Lopez FB; Genetics and Biotechnology Laboratory, Plant & AgriBiosciences Research Centre (PABC), Ryan Institute, National University of Ireland Galway, Galway H91 REW4, Ireland.
Fort A; Genetics and Biotechnology Laboratory, Plant & AgriBiosciences Research Centre (PABC), Ryan Institute, National University of Ireland Galway, Galway H91 REW4, Ireland.; Systems Biology Laboratory, Plant & AgriBiosciences Research Centre (PABC), Ryan Institute, National University of Ireland Galway, Galway H91 REW4, Ireland.
Tadini L; Dipartimento di Bioscienze, Universit� degli Studi di Milano, 20133 Milano, Italy.
Probst AV; CNRS, GReD, Universit� Clermont Auvergne, INSERM, 63001 Clermont-Ferrand, France.
McHale M; Genetics and Biotechnology Laboratory, Plant & AgriBiosciences Research Centre (PABC), Ryan Institute, National University of Ireland Galway, Galway H91 REW4, Ireland.; Systems Biology Laboratory, Plant & AgriBiosciences Research Centre (PABC), Ryan Institute, National University of Ireland Galway, Galway H91 REW4, Ireland.
Friel J; Genetics and Biotechnology Laboratory, Plant & AgriBiosciences Research Centre (PABC), Ryan Institute, National University of Ireland Galway, Galway H91 REW4, Ireland.
Ryder P; Genetics and Biotechnology Laboratory, Plant & AgriBiosciences Research Centre (PABC), Ryan Institute, National University of Ireland Galway, Galway H91 REW4, Ireland.
Pontvianne FDR; CNRS, Laboratoire G�nome et D�veloppement des Plantes (LGDP), Universit� de Perpignan Via Domitia, Perpignan, France.
Pesaresi P; Dipartimento di Bioscienze, Universit� degli Studi di Milano, 20133 Milano, Italy.
Sulpice R; Systems Biology Laboratory, Plant & AgriBiosciences Research Centre (PABC), Ryan Institute, National University of Ireland Galway, Galway H91 REW4, Ireland.
McKeown P; Genetics and Biotechnology Laboratory, Plant & AgriBiosciences Research Centre (PABC), Ryan Institute, National University of Ireland Galway, Galway H91 REW4, Ireland.
Brychkova G; Genetics and Biotechnology Laboratory, Plant & AgriBiosciences Research Centre (PABC), Ryan Institute, National University of Ireland Galway, Galway H91 REW4, Ireland.
Spillane C; Genetics and Biotechnology Laboratory, Plant & AgriBiosciences Research Centre (PABC), Ryan Institute, National University of Ireland Galway, Galway H91 REW4, Ireland.
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Źródło :
The Plant cell [Plant Cell] 2021 May 31; Vol. 33 (4), pp. 1135-1150.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Dosage Compensation, Genetic*
Gene Dosage*
Arabidopsis/*genetics
CRISPR-Cas Systems ; Chromatin/genetics ; DNA, Ribosomal/genetics ; Gene Expression Regulation, Plant ; Genomic Instability ; Plants, Genetically Modified ; RNA, Ribosomal/metabolism
Czasopismo naukowe
Tytuł :
A systems genetics approach to deciphering the effect of dosage variation on leaf morphology in Populus.
Autorzy :
Bastiaanse HLS; Pacific Southwest Research Station, US Forest Service, Davis, California 95618.; Genome Center, University of California Davis, Davis 95616.
Henry IM; Genome Center, University of California Davis, Davis 95616.; Department of Plant Biology, University of California Davis, Davis 95616.
Tsai H; Genome Center, University of California Davis, Davis 95616.; Department of Plant Biology, University of California Davis, Davis 95616.
Lieberman M; Genome Center, University of California Davis, Davis 95616.; Department of Plant Biology, University of California Davis, Davis 95616.
Canning C; Pacific Southwest Research Station, US Forest Service, Davis, California 95618.
Comai L; Genome Center, University of California Davis, Davis 95616.; Department of Plant Biology, University of California Davis, Davis 95616.
Groover A; Pacific Southwest Research Station, US Forest Service, Davis, California 95618.; Genome Center, University of California Davis, Davis 95616.
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Źródło :
The Plant cell [Plant Cell] 2021 May 31; Vol. 33 (4), pp. 940-960.
Typ publikacji :
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Gene Dosage*
Plant Leaves/*physiology
Populus/*genetics
Chromosomes, Plant ; Gene Expression Regulation, Plant ; Gene Regulatory Networks ; Genes, Plant ; Phenotype ; Plant Leaves/genetics ; Populus/physiology ; Quantitative Trait Loci
Czasopismo naukowe
Tytuł :
Determination of incompatibility group plasmids and copy number of the blaNDM-1 gene in carbapenem-resistant Klebsiella pneumoniae strains recovered from different hospitals in Kerman, Iran.
Autorzy :
Aslani S; Department of Medical Microbiology (Bacteriology & Virology), Afzalipour Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran.; Medical Mycology and Bacteriology Research Center, Kerman University of Medical Sciences, Kerman, Iran.
Kiaei S; Student Research Committee, Kerman University of Medical Sciences, Kerman, Iran.
Afgar A; Research Center for Hydatid Disease in Iran, Kerman University of Medical Sciences, Kerman, Iran.
Morones-Ramírez JR; Centro de Investigación en Biotecnología y Nanotecnología, Facultad de Ciencias Químicas, Parque de Investigación e Innovación Tecnológica, Universidad Autónoma de Nuevo León, Apodaca, Mexico.; Facultad de Ciencias Químicas, Universidad Autónoma de Nuevo León, UANL, San Nicolás de los Garza, Mexico.
Aratboni HA; Centro de Investigación en Biotecnología y Nanotecnología, Facultad de Ciencias Químicas, Parque de Investigación e Innovación Tecnológica, Universidad Autónoma de Nuevo León, Apodaca, Mexico.; Facultad de Ciencias Químicas, Universidad Autónoma de Nuevo León, UANL, San Nicolás de los Garza, Mexico.
Faridi A; Student Research Committee, Kerman University of Medical Sciences, Kerman, Iran.
Rivera-Mackintosh LR; Centro de Investigación en Biotecnología y Nanotecnología, Facultad de Ciencias Químicas, Parque de Investigación e Innovación Tecnológica, Universidad Autónoma de Nuevo León, Apodaca, Mexico.; Facultad de Ciencias Químicas, Universidad Autónoma de Nuevo León, UANL, San Nicolás de los Garza, Mexico.
Kalantar-Neyestanaki D; Department of Medical Microbiology (Bacteriology & Virology), Afzalipour Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran.; Medical Mycology and Bacteriology Research Center, Kerman University of Medical Sciences, Kerman, Iran.
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Źródło :
Journal of medical microbiology [J Med Microbiol] 2021 May; Vol. 70 (5).
Typ publikacji :
Journal Article
MeSH Terms :
Gene Dosage*
Plasmids*
Anti-Bacterial Agents/*pharmacology
Carbapenems/*pharmacology
Klebsiella Infections/*microbiology
Klebsiella pneumoniae/*drug effects
Klebsiella pneumoniae/*genetics
beta-Lactamases/*genetics
Humans ; Iran ; Klebsiella pneumoniae/classification ; Molecular Typing ; Random Amplified Polymorphic DNA Technique ; Replicon ; beta-Lactam Resistance
Czasopismo naukowe

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