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Tytuł:
Multiplexed gene synthesis in emulsions for exploring protein functional landscapes.
Autorzy:
Plesa C; Department of Chemistry and Biochemistry, University of California, Los Angeles (UCLA), Los Angeles, CA, USA.
Sidore AM; Department of Chemical and Biomolecular Engineering, UCLA, Los Angeles, CA, USA.
Lubock NB; Department of Chemistry and Biochemistry, University of California, Los Angeles (UCLA), Los Angeles, CA, USA.
Zhang D; Genomics and Computational Biology Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Kosuri S; Department of Chemistry and Biochemistry, University of California, Los Angeles (UCLA), Los Angeles, CA, USA.; UCLA-U.S. Department of Energy Institute for Genomics and Proteomics, Molecular Biology Institute, Quantitative and Computational Biology Institute, Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA, USA.
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Źródło:
Science (New York, N.Y.) [Science] 2018 Jan 19; Vol. 359 (6373), pp. 343-347. Date of Electronic Publication: 2018 Jan 04.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Genes, Synthetic*
Proteins/*physiology
Emulsions ; Escherichia coli/genetics ; Gene Knockout Techniques ; Genes, Essential ; Genetic Complementation Test ; Oligonucleotides/chemical synthesis ; Oligonucleotides/chemistry ; Oligonucleotides/genetics ; Proteins/genetics ; Synthetic Biology/methods
Czasopismo naukowe
Tytuł:
Regulatory effects of the Uty/Ddx3y locus on neighboring chromosome Y genes and autosomal mRNA transcripts in adult mouse non-reproductive cells.
Autorzy:
Deschepper CF; Cardiovascular Biology Research Unit, Institut de Recherches Cliniques de Montréal (IRCM) and Université de Montréal, 100 Pine Ave West, Montréal, QC, H2W 1R7, Canada. .
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Źródło:
Scientific reports [Sci Rep] 2020 Sep 10; Vol. 10 (1), pp. 14900. Date of Electronic Publication: 2020 Sep 10.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Gene Expression Regulation*
Genes, Y-Linked*
Chromatin/*genetics
DEAD-box RNA Helicases/*genetics
Minor Histocompatibility Antigens/*genetics
Proteins/*genetics
RNA, Messenger/*genetics
Y Chromosome/*genetics
Animals ; Female ; Male ; Mice ; Mice, Inbred C57BL ; Myocytes, Cardiac/cytology ; Myocytes, Cardiac/metabolism ; Transcriptome
Czasopismo naukowe
Tytuł:
Overlapping genes and the proteins they encode differ significantly in their sequence composition from non-overlapping genes.
Autorzy:
Pavesi A; Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, Parma, Italy.
Vianelli A; Department of Theoretical and Applied Sciences, University of Insubria, Varese, Italy.
Chirico N; Department of Theoretical and Applied Sciences, University of Insubria, Varese, Italy.
Bao Y; BIG Data Center, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China.
Blinkova O; National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD, United States of America.
Belshaw R; School of Biomedical & Healthcare Sciences, Plymouth University Peninsula Schools of Medicine and Dentistry (PUPSMD), Plymouth, United Kingdom.
Firth A; Department of Pathology, Division of Virology, University of Cambridge, Cambridge, United Kingdom.
Karlin D; Department of Zoology, University of Oxford, Oxford, United Kingdom.; Division of Structural Biology, University of Oxford, Oxford, United Kingdom.
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Źródło:
PloS one [PLoS One] 2018 Oct 19; Vol. 13 (10), pp. e0202513. Date of Electronic Publication: 2018 Oct 19 (Print Publication: 2018).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Evolution, Molecular*
Genes, Overlapping/*genetics
Proteins/*genetics
Amino Acid Sequence/genetics ; Animals ; Genes, Viral/genetics ; Mammals/genetics ; Mutation ; Open Reading Frames/genetics ; Principal Component Analysis
Czasopismo naukowe
Tytuł:
A novel pathogenic variant in the LRTOMT gene causes autosomal recessive non-syndromic hearing loss in an Iranian family.
Autorzy:
Sarmadi A; Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.; Genetics Department, Erythron Pathobiology and Genetics lab, Isfahan, Iran.
Nasrniya S; Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Soleimani Farsani M; Department of Biotechnology, Faculty of Advanced Sciences and Technologies, University of Isfahan, Isfahan, Iran.
Narrei S; Genetics Department, Erythron Pathobiology and Genetics lab, Isfahan, Iran.
Nouri Z; Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Sepehrnejad M; Department of Otolaryngology, Al-Zahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran.
Nilforoush MH; Department of Otolaryngology, Al-Zahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran.
Abtahi H; Department of Otolaryngology, Al-Zahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran.
Tabatabaiefar MA; Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran. .; Pediatric Inherited Diseases Research Center, Research Institute for Primordial Prevention of Noncommunicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran. .; GenTArget Corp (GTAC), Deputy of Research and Technology, Isfahan University of Medical Sciences, Isfahan, Iran. .
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Źródło:
BMC medical genetics [BMC Med Genet] 2020 Jun 09; Vol. 21 (1), pp. 127. Date of Electronic Publication: 2020 Jun 09.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Genes, Recessive*
Hearing Loss, Sensorineural/*genetics
Mutation/*genetics
Proteins/*genetics
Amino Acid Sequence ; Base Sequence ; Child, Preschool ; Family ; Humans ; Iran ; Male ; Models, Molecular ; Proteins/chemistry
Czasopismo naukowe
Tytuł:
Genomic profiling of the UFMylation family genes identifies UFSP2 as a potential tumour suppressor in colon cancer.
Autorzy:
Zhou J; Key Laboratory of Aging and Cancer Biology of Zhejiang Province, School of Basic Medicine, Hangzhou Normal University, 2318 Yu hang tang Rd, Hangzhou, Zhejiang, 311121, China.
Ma X; Key Laboratory of Aging and Cancer Biology of Zhejiang Province, School of Basic Medicine, Hangzhou Normal University, 2318 Yu hang tang Rd, Hangzhou, Zhejiang, 311121, China.
Xu L; Key Laboratory of Aging and Cancer Biology of Zhejiang Province, School of Basic Medicine, Hangzhou Normal University, 2318 Yu hang tang Rd, Hangzhou, Zhejiang, 311121, China.
Liang Q; Key Laboratory of Aging and Cancer Biology of Zhejiang Province, School of Basic Medicine, Hangzhou Normal University, 2318 Yu hang tang Rd, Hangzhou, Zhejiang, 311121, China.
Mao J; Key Laboratory of Aging and Cancer Biology of Zhejiang Province, School of Basic Medicine, Hangzhou Normal University, 2318 Yu hang tang Rd, Hangzhou, Zhejiang, 311121, China.
Liu J; Key Laboratory of Aging and Cancer Biology of Zhejiang Province, School of Basic Medicine, Hangzhou Normal University, 2318 Yu hang tang Rd, Hangzhou, Zhejiang, 311121, China.
Wang M; Key Laboratory of Aging and Cancer Biology of Zhejiang Province, School of Basic Medicine, Hangzhou Normal University, 2318 Yu hang tang Rd, Hangzhou, Zhejiang, 311121, China.
Yuan J; Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Cong YS; Key Laboratory of Aging and Cancer Biology of Zhejiang Province, School of Basic Medicine, Hangzhou Normal University, 2318 Yu hang tang Rd, Hangzhou, Zhejiang, 311121, China.
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Źródło:
Clinical and translational medicine [Clin Transl Med] 2021 Dec; Vol. 11 (12), pp. e642.
Typ publikacji:
Letter; Research Support, Non-U.S. Gov't
MeSH Terms:
Colonic Neoplasms/*genetics
Genes, Tumor Suppressor/*drug effects
Proteins/*pharmacology
Colonic Neoplasms/drug therapy ; Genetic Profile ; Genomics/methods ; Genomics/statistics & numerical data ; Humans
Raport
Tytuł:
Network-based methods for predicting essential genes or proteins: a survey.
Autorzy:
Li X; School of Computer Science and Engineering, Central South University, Changsha, Hunan, China.
Li W; School of Computer Science and Engineering, Central South University, Changsha, Hunan, China.
Zeng M; School of Computer Science and Engineering, Central South University, Changsha, Hunan, China.
Zheng R; School of Computer Science and Engineering, Central South University, Changsha, Hunan, China.
Li M; School of Computer Science and Engineering, Central South University, Changsha, Hunan, China.
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Źródło:
Briefings in bioinformatics [Brief Bioinform] 2020 Mar 23; Vol. 21 (2), pp. 566-583.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Genes, Essential*
Proteins/*chemistry
Computational Biology/methods ; Genome ; Surveys and Questionnaires
Czasopismo naukowe
Tytuł:
Ultrasound imaging of gene expression in mammalian cells.
Autorzy:
Farhadi A; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
Ho GH; Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA, USA.
Sawyer DP; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
Bourdeau RW; Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA, USA.
Shapiro MG; Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA, USA. .
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Źródło:
Science (New York, N.Y.) [Science] 2019 Sep 27; Vol. 365 (6460), pp. 1469-1475.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Gene Expression*
Genes, Reporter*
Ultrasonography*
Proteins/*genetics
Acoustics ; Animals ; Bacillus megaterium/genetics ; CHO Cells ; Cricetulus ; Dolichospermum flos-aquae/genetics ; HEK293 Cells ; Halobacterium salinarum/genetics ; Humans ; Mice ; Mice, Inbred NOD ; Mice, SCID ; Multigene Family ; Nanostructures/chemistry ; Transfection
Czasopismo naukowe
Tytuł:
Analysis of Protein-Protein Functional Associations by Using Gene Ontology and KEGG Pathway.
Autorzy:
Yuan F; Department of Science & Technology, Binzhou Medical University Hospital, Binzhou 256603, Shandong, China.
Pan X; BASF & IDLab, Ghent University, Ghent, Belgium.
Chen L; College of Information Engineering, Shanghai Maritime University, Shanghai 201306, China.; Shanghai Key Laboratory of PMMP, East China Normal University, Shanghai 200241, China.
Zhang YH; Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
Huang T; Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
Cai YD; School of Life Sciences, Shanghai University, Shanghai 200444, China.
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Źródło:
BioMed research international [Biomed Res Int] 2019 Jul 18; Vol. 2019, pp. 4963289. Date of Electronic Publication: 2019 Jul 18 (Print Publication: 2019).
Typ publikacji:
Journal Article
MeSH Terms:
Databases, Protein*
Gene Ontology*
Genes, Essential*
Proteins*/genetics
Proteins*/metabolism
Computational Biology
Czasopismo naukowe
Tytuł:
Characterization of the western white pine TIR-NBS-LRR ( PmTNL2 ) gene by transcript profiling and promoter analysis.
Autorzy:
Liu JJ; a Canadian Forest Service, Natural Resources Canada, 506 West Burnside Road, Victoria, BC V8Z 1M5, Canada.
Xiang Y; b Summerland Research and Development Centre, Agriculture and Agri-Food Canada, Summerland, BC V0H 1Z0, Canada.
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Źródło:
Genome [Genome] 2019 Jul; Vol. 62 (7), pp. 477-488. Date of Electronic Publication: 2019 May 27.
Typ publikacji:
Journal Article
MeSH Terms:
Genes, Plant*
Promoter Regions, Genetic*
Pinus/*genetics
Proteins/*genetics
Amino Acid Sequence ; Arabidopsis/genetics ; Binding Sites ; Gene Expression Profiling ; Gene Expression Regulation, Plant ; Leucine-Rich Repeat Proteins ; Meristem/genetics ; Phylogeny ; Plants, Genetically Modified/genetics
Czasopismo naukowe
Tytuł:
Development of Genetic Modification Tools for Hanseniaspora uvarum .
Autorzy:
Badura J; Department of Microbiology and Biochemistry, Hochschule Geisenheim University, Von-Lade-Strasse 1, 65366 Geisenheim, Germany.
van Wyk N; Department of Microbiology and Biochemistry, Hochschule Geisenheim University, Von-Lade-Strasse 1, 65366 Geisenheim, Germany.; ARC Centre of Excellence in Synthetic Biology, Department of Molecular Sciences, Macquarie University, Sydney, NSW 2113, Australia.
Brezina S; Department of Microbiology and Biochemistry, Hochschule Geisenheim University, Von-Lade-Strasse 1, 65366 Geisenheim, Germany.
Pretorius IS; ARC Centre of Excellence in Synthetic Biology, Department of Molecular Sciences, Macquarie University, Sydney, NSW 2113, Australia.
Rauhut D; Department of Microbiology and Biochemistry, Hochschule Geisenheim University, Von-Lade-Strasse 1, 65366 Geisenheim, Germany.
Wendland J; Department of Microbiology and Biochemistry, Hochschule Geisenheim University, Von-Lade-Strasse 1, 65366 Geisenheim, Germany.
von Wallbrunn C; Department of Microbiology and Biochemistry, Hochschule Geisenheim University, Von-Lade-Strasse 1, 65366 Geisenheim, Germany.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Feb 16; Vol. 22 (4). Date of Electronic Publication: 2021 Feb 16.
Typ publikacji:
Journal Article
MeSH Terms:
Gene Deletion*
Genetic Engineering/*methods
Hanseniaspora/*enzymology
Hanseniaspora/*genetics
Microorganisms, Genetically-Modified/*genetics
Proteins/*genetics
Acetates/metabolism ; Alleles ; Fermentation/genetics ; Genes, Fungal ; Open Reading Frames ; Phenotype ; Promoter Regions, Genetic ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae Proteins/genetics ; Vitis/metabolism ; Wine
SCR Organism:
Hanseniaspora uvarum
Czasopismo naukowe
Tytuł:
A malectin-like/leucine-rich repeat receptor protein kinase gene, RLK-V, regulates powdery mildew resistance in wheat.
Autorzy:
Hu P; National Key Laboratory of Crop Genetics and Germplasm Enhancement, Cytogenetics Institute, Nanjing Agricultural University/JCIC-MCP, Nanjing, 210095, China.; Henan Collaborative Innovation Center of Modern Biological Breeding, Henan Institute of Science and Technology, 453003, China.
Liu J; National Key Laboratory of Crop Genetics and Germplasm Enhancement, Cytogenetics Institute, Nanjing Agricultural University/JCIC-MCP, Nanjing, 210095, China.
Xu J; National Key Laboratory of Crop Genetics and Germplasm Enhancement, Cytogenetics Institute, Nanjing Agricultural University/JCIC-MCP, Nanjing, 210095, China.
Zhou C; National Key Laboratory of Crop Genetics and Germplasm Enhancement, Cytogenetics Institute, Nanjing Agricultural University/JCIC-MCP, Nanjing, 210095, China.
Cao S; National Key Laboratory of Crop Genetics and Germplasm Enhancement, Cytogenetics Institute, Nanjing Agricultural University/JCIC-MCP, Nanjing, 210095, China.
Zhou W; National Key Laboratory of Crop Genetics and Germplasm Enhancement, Cytogenetics Institute, Nanjing Agricultural University/JCIC-MCP, Nanjing, 210095, China.
Huang Z; National Key Laboratory of Crop Genetics and Germplasm Enhancement, Cytogenetics Institute, Nanjing Agricultural University/JCIC-MCP, Nanjing, 210095, China.
Yuan S; National Key Laboratory of Crop Genetics and Germplasm Enhancement, Cytogenetics Institute, Nanjing Agricultural University/JCIC-MCP, Nanjing, 210095, China.
Wang X; National Key Laboratory of Crop Genetics and Germplasm Enhancement, Cytogenetics Institute, Nanjing Agricultural University/JCIC-MCP, Nanjing, 210095, China.
Xiao J; National Key Laboratory of Crop Genetics and Germplasm Enhancement, Cytogenetics Institute, Nanjing Agricultural University/JCIC-MCP, Nanjing, 210095, China.
Zhang R; National Key Laboratory of Crop Genetics and Germplasm Enhancement, Cytogenetics Institute, Nanjing Agricultural University/JCIC-MCP, Nanjing, 210095, China.
Wang H; National Key Laboratory of Crop Genetics and Germplasm Enhancement, Cytogenetics Institute, Nanjing Agricultural University/JCIC-MCP, Nanjing, 210095, China.
Zhang S; National Key Laboratory of Crop Genetics and Germplasm Enhancement, Cytogenetics Institute, Nanjing Agricultural University/JCIC-MCP, Nanjing, 210095, China.
Xing L; National Key Laboratory of Crop Genetics and Germplasm Enhancement, Cytogenetics Institute, Nanjing Agricultural University/JCIC-MCP, Nanjing, 210095, China.
Cao A; National Key Laboratory of Crop Genetics and Germplasm Enhancement, Cytogenetics Institute, Nanjing Agricultural University/JCIC-MCP, Nanjing, 210095, China.
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Źródło:
Molecular plant pathology [Mol Plant Pathol] 2018 Dec; Vol. 19 (12), pp. 2561-2574. Date of Electronic Publication: 2018 Oct 16.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Genes, Plant*
Ascomycota/*physiology
Disease Resistance/*genetics
Plant Diseases/*genetics
Plant Diseases/*microbiology
Proteins/*genetics
Triticum/*genetics
Triticum/*microbiology
Alternative Splicing/genetics ; Base Sequence ; Cell Death ; Chromosomes, Plant/genetics ; Disease Susceptibility ; Gene Expression Regulation, Plant ; Hydrogen Peroxide/metabolism ; Leucine-Rich Repeat Proteins ; Plant Proteins/genetics ; Plant Proteins/metabolism ; Plant Viruses/physiology ; Promoter Regions, Genetic/genetics ; Proteins/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Nicotiana/microbiology ; Up-Regulation/genetics
SCR Organism:
Barley stripe mosaic virus
Czasopismo naukowe
Tytuł:
Genomic evidence for genes encoding leucine-rich repeat receptors linked to resistance against the eukaryotic extra- and intracellular Brassica napus pathogens Leptosphaeria maculans and Plasmodiophora brassicae.
Autorzy:
Stotz HU; School of Life and Medical Sciences, University of Hertfordshire, Hatfield, United Kingdom.
Harvey PJ; School of Life and Medical Sciences, University of Hertfordshire, Hatfield, United Kingdom.
Haddadi P; Saskatoon Research Centre, Agriculture and Agri-Food Canada, Saskatoon, SK, Canada.
Mashanova A; School of Life and Medical Sciences, University of Hertfordshire, Hatfield, United Kingdom.
Kukol A; School of Life and Medical Sciences, University of Hertfordshire, Hatfield, United Kingdom.
Larkan NJ; Armatus Genetics Inc., Saskatoon, SK, Canada.
Borhan MH; Saskatoon Research Centre, Agriculture and Agri-Food Canada, Saskatoon, SK, Canada.
Fitt BDL; School of Life and Medical Sciences, University of Hertfordshire, Hatfield, United Kingdom.
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Źródło:
PloS one [PLoS One] 2018 Jun 01; Vol. 13 (6), pp. e0198201. Date of Electronic Publication: 2018 Jun 01 (Print Publication: 2018).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Genes, Plant*
Genome, Plant*
Ascomycota/*physiology
Brassica napus/*genetics
Disease Resistance/*genetics
Host-Parasite Interactions/*genetics
Plant Diseases/*genetics
Plant Proteins/*genetics
Plasmodiophorida/*physiology
Proteins/*genetics
Brassica napus/parasitology ; Genome-Wide Association Study ; Leucine-Rich Repeat Proteins ; Models, Molecular ; Multigene Family ; Phylogeny ; Plant Cells/microbiology ; Plant Cells/parasitology ; Plant Proteins/chemistry ; Plant Proteins/physiology ; Protein Conformation ; Proteins/chemistry ; Proteins/physiology ; Sequence Alignment ; Sequence Homology, Amino Acid
Czasopismo naukowe
Tytuł:
SLAM-seq defines direct gene-regulatory functions of the BRD4-MYC axis.
Autorzy:
Muhar M; Research Institute of Molecular Pathology (IMP), Vienna BioCenter (VBC), 1030 Vienna, Austria.
Ebert A; Research Institute of Molecular Pathology (IMP), Vienna BioCenter (VBC), 1030 Vienna, Austria.
Neumann T; Research Institute of Molecular Pathology (IMP), Vienna BioCenter (VBC), 1030 Vienna, Austria.
Umkehrer C; Research Institute of Molecular Pathology (IMP), Vienna BioCenter (VBC), 1030 Vienna, Austria.
Jude J; Research Institute of Molecular Pathology (IMP), Vienna BioCenter (VBC), 1030 Vienna, Austria.
Wieshofer C; Boehringer Ingelheim-Regional Center Vienna GmbH and Company KG, 1121 Vienna, Austria.
Rescheneder P; Center for Integrative Bioinformatics Vienna, Max F. Perutz Laboratories, University of Vienna and Medical University of Vienna, 1030 Vienna, Austria.
Lipp JJ; Research Institute of Molecular Pathology (IMP), Vienna BioCenter (VBC), 1030 Vienna, Austria.
Herzog VA; Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), VBC, 1030 Vienna, Austria.
Reichholf B; Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), VBC, 1030 Vienna, Austria.
Cisneros DA; Research Institute of Molecular Pathology (IMP), Vienna BioCenter (VBC), 1030 Vienna, Austria.
Hoffmann T; Research Institute of Molecular Pathology (IMP), Vienna BioCenter (VBC), 1030 Vienna, Austria.
Schlapansky MF; Research Institute of Molecular Pathology (IMP), Vienna BioCenter (VBC), 1030 Vienna, Austria.
Bhat P; Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), VBC, 1030 Vienna, Austria.
von Haeseler A; Center for Integrative Bioinformatics Vienna, Max F. Perutz Laboratories, University of Vienna and Medical University of Vienna, 1030 Vienna, Austria.
Köcher T; Vienna Biocenter Core Facilities (VBCF), 1030 Vienna, Austria.
Obenauf AC; Research Institute of Molecular Pathology (IMP), Vienna BioCenter (VBC), 1030 Vienna, Austria.
Popow J; Boehringer Ingelheim-Regional Center Vienna GmbH and Company KG, 1121 Vienna, Austria.
Ameres SL; Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), VBC, 1030 Vienna, Austria. .
Zuber J; Research Institute of Molecular Pathology (IMP), Vienna BioCenter (VBC), 1030 Vienna, Austria. .; Medical University of Vienna, VBC, 1030 Vienna, Austria.
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Źródło:
Science (New York, N.Y.) [Science] 2018 May 18; Vol. 360 (6390), pp. 800-805. Date of Electronic Publication: 2018 Apr 05.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Genes, Regulator*
Antineoplastic Agents/*pharmacology
Gene Expression Regulation, Leukemic/*drug effects
Leukemia, Myeloid/*drug therapy
Nuclear Proteins/*metabolism
Proteins/*antagonists & inhibitors
Proto-Oncogene Proteins c-myc/*metabolism
Transcription Factors/*metabolism
Antineoplastic Agents/therapeutic use ; Cell Cycle Proteins ; Dose-Response Relationship, Drug ; Humans ; Leukemia, Myeloid/genetics ; Molecular Targeted Therapy ; Nuclear Proteins/genetics ; Proto-Oncogene Proteins c-myc/genetics ; Purines/biosynthesis ; RNA, Messenger/biosynthesis ; RNA, Messenger/genetics ; Ribosomes/metabolism ; Sequence Analysis, RNA ; Transcription Factors/genetics ; Transcription, Genetic
Czasopismo naukowe
Tytuł:
Top-ranked expressed gene transcripts of human protein-coding genes investigated with GTEx dataset.
Autorzy:
Tung KF; Institute of Biomedical Sciences, Academia Sinica, Taipei, 115, Taiwan, ROC.
Pan CY; Institute of Biomedical Sciences, Academia Sinica, Taipei, 115, Taiwan, ROC.; Institute of Biomedical Informatics, National Yang-Ming University, Taipei, Taiwan, ROC.
Chen CH; Institute of Biomedical Sciences, Academia Sinica, Taipei, 115, Taiwan, ROC.
Lin WC; Institute of Biomedical Sciences, Academia Sinica, Taipei, 115, Taiwan, ROC. .; Institute of Biomedical Informatics, National Yang-Ming University, Taipei, Taiwan, ROC. .
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Źródło:
Scientific reports [Sci Rep] 2020 Oct 01; Vol. 10 (1), pp. 16245. Date of Electronic Publication: 2020 Oct 01.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Datasets as Topic*
Transcriptome*/genetics
Genes/*genetics
Proteins/*genetics
Gene Expression ; Gene Expression Profiling/methods ; Humans
Czasopismo naukowe
Tytuł:
Nucleotide substitution rates of diatom plastid encoded protein genes are positively correlated with genome architecture.
Autorzy:
Ren Y; The Davies Research Centre, School of Animal and Veterinary Sciences, University of Adelaide, Roseworthy, SA, 5371, Australia.
Yu M; Department of Integrative Biology, University of Texas at Austin, Austin, TX, USA.
Low WY; The Davies Research Centre, School of Animal and Veterinary Sciences, University of Adelaide, Roseworthy, SA, 5371, Australia.
Ruhlman TA; Department of Integrative Biology, University of Texas at Austin, Austin, TX, USA.
Hajrah NH; Center of Excellence for Bionanoscience Research, King Abdul Aziz University, Jeddah, Saudi Arabia.
El Omri A; Center of Excellence for Bionanoscience Research, King Abdul Aziz University, Jeddah, Saudi Arabia.
Alghamdi MK; Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.
Sabir MJ; Department of Information Technology, Faculty of Computer Science and Information Technology, King Abdul Aziz University, Jeddah, Saudi Arabia.
Alhebshi AM; Center of Excellence for Bionanoscience Research, King Abdul Aziz University, Jeddah, Saudi Arabia.
Kamli MR; Center of Excellence for Bionanoscience Research, King Abdul Aziz University, Jeddah, Saudi Arabia.
Sabir JSM; Center of Excellence for Bionanoscience Research, King Abdul Aziz University, Jeddah, Saudi Arabia.
Theriot EC; Department of Integrative Biology, University of Texas at Austin, Austin, TX, USA.
Jansen RK; Department of Integrative Biology, University of Texas at Austin, Austin, TX, USA. .
Rather IA; Center of Excellence for Bionanoscience Research, King Abdul Aziz University, Jeddah, Saudi Arabia. .
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Źródło:
Scientific reports [Sci Rep] 2020 Sep 01; Vol. 10 (1), pp. 14358. Date of Electronic Publication: 2020 Sep 01.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Genome, Plastid*
Base Sequence/*genetics
Diatoms/*cytology
Nucleotides/*genetics
Plastids/*genetics
Proteins/*genetics
Diatoms/genetics ; Ecosystem ; Evolution, Molecular ; Gene Order ; Genes, Essential ; Genetic Heterogeneity ; Inverted Repeat Sequences ; Photosynthesis/genetics ; Phylogeny
Czasopismo naukowe
Tytuł:
The Evolution of Duplicated Genes of the Cpi-17/Phi-1 ( ppp1r14 ) Family of Protein Phosphatase 1 Inhibitors in Teleosts.
Autorzy:
Lang I; Department of Biological Sciences, University of the Pacific, Stockton, CA 98211, USA.
Virk G; Department of Biological Sciences, University of the Pacific, Stockton, CA 98211, USA.
Zheng DC; Department of Biological Sciences, University of the Pacific, Stockton, CA 98211, USA.
Young J; Department of Biological Sciences, University of the Pacific, Stockton, CA 98211, USA.
Nguyen MJ; Department of Biological Sciences, University of the Pacific, Stockton, CA 98211, USA.
Amiri R; Department of Biological Sciences, University of the Pacific, Stockton, CA 98211, USA.
Fong M; Department of Biological Sciences, University of the Pacific, Stockton, CA 98211, USA.
Arata A; Department of Biological Sciences, University of the Pacific, Stockton, CA 98211, USA.
Chadaideh KS; Department of Biological Sciences, University of the Pacific, Stockton, CA 98211, USA.; Department of Human Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA.
Walsh S; Life Sciences, Soka University of America, Aliso Viejo, CA 92656, USA.
Weiser DC; Department of Biological Sciences, University of the Pacific, Stockton, CA 98211, USA.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2020 Aug 09; Vol. 21 (16). Date of Electronic Publication: 2020 Aug 09.
Typ publikacji:
Journal Article
MeSH Terms:
Fish Proteins/*genetics
Genes, Duplicate/*genetics
Intracellular Signaling Peptides and Proteins/*genetics
Muscle Proteins/*genetics
Proteins/*genetics
Amino Acid Sequence ; Animals ; Embryo, Nonmammalian/embryology ; Embryo, Nonmammalian/metabolism ; Evolution, Molecular ; Fish Proteins/classification ; Fish Proteins/metabolism ; Gene Expression Profiling ; Gene Expression Regulation, Developmental ; HEK293 Cells ; HeLa Cells ; Humans ; Intracellular Signaling Peptides and Proteins/classification ; Intracellular Signaling Peptides and Proteins/metabolism ; Muscle Proteins/classification ; Muscle Proteins/metabolism ; Phosphoprotein Phosphatases/classification ; Phosphoprotein Phosphatases/genetics ; Phosphoprotein Phosphatases/metabolism ; Phylogeny ; Proteins/classification ; Proteins/metabolism ; Sequence Homology, Amino Acid ; Zebrafish/embryology ; Zebrafish/genetics ; Zebrafish/metabolism
Czasopismo naukowe
Tytuł:
Discovery of gas vesicles in Streptomyces sp. CB03234-S and potential effects of gas vesicle gene overexpression on morphological and metabolic changes in streptomycetes.
Autorzy:
Huang R; Xiangya International Academy of Translational Medicine, Central South University, Tongzipo Road, #172, Yuelu District, Changsha, 410013, Hunan, China.
Lin J; Xiangya International Academy of Translational Medicine, Central South University, Tongzipo Road, #172, Yuelu District, Changsha, 410013, Hunan, China.
Gao D; Xiangya International Academy of Translational Medicine, Central South University, Tongzipo Road, #172, Yuelu District, Changsha, 410013, Hunan, China.
Zhang F; Xiangya International Academy of Translational Medicine, Central South University, Tongzipo Road, #172, Yuelu District, Changsha, 410013, Hunan, China.
Yi L; Xiangya International Academy of Translational Medicine, Central South University, Tongzipo Road, #172, Yuelu District, Changsha, 410013, Hunan, China.
Huang Y; Xiangya International Academy of Translational Medicine, Central South University, Tongzipo Road, #172, Yuelu District, Changsha, 410013, Hunan, China.; National Engineering Research Center of Combinatorial Biosynthesis for Drug Discovery, Changsha, 410013, Hunan, China.
Yan X; Xiangya International Academy of Translational Medicine, Central South University, Tongzipo Road, #172, Yuelu District, Changsha, 410013, Hunan, China.; National Engineering Research Center of Combinatorial Biosynthesis for Drug Discovery, Changsha, 410013, Hunan, China.
Duan Y; Xiangya International Academy of Translational Medicine, Central South University, Tongzipo Road, #172, Yuelu District, Changsha, 410013, Hunan, China. .; Hunan Engineering Research Center of Combinatorial Biosynthesis and Natural Product Drug Discovery, Changsha, China. .; National Engineering Research Center of Combinatorial Biosynthesis for Drug Discovery, Changsha, 410013, Hunan, China. .
Zhu X; Xiangya International Academy of Translational Medicine, Central South University, Tongzipo Road, #172, Yuelu District, Changsha, 410013, Hunan, China. .; Hunan Engineering Research Center of Combinatorial Biosynthesis and Natural Product Drug Discovery, Changsha, China. .; National Engineering Research Center of Combinatorial Biosynthesis for Drug Discovery, Changsha, 410013, Hunan, China. .
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Źródło:
Applied microbiology and biotechnology [Appl Microbiol Biotechnol] 2019 Jul; Vol. 103 (14), pp. 5751-5761. Date of Electronic Publication: 2019 May 21.
Typ publikacji:
Journal Article
MeSH Terms:
Gene Expression Regulation, Bacterial*
Proteins/*genetics
Streptomyces/*genetics
Streptomyces/*metabolism
Vacuoles/*physiology
Bacterial Proteins/genetics ; Computational Biology ; Gene Expression Profiling ; Genes, Bacterial ; Membrane Proteins/genetics ; Multigene Family ; Streptomyces coelicolor/genetics
Czasopismo naukowe
Tytuł:
ORANGE: A CRISPR/Cas9-based genome editing toolbox for epitope tagging of endogenous proteins in neurons.
Autorzy:
Willems J; Cell Biology, Neurobiology and Biophysics, Department of Biology, Faculty of Science, Utrecht University, Utrecht, the Netherlands.
de Jong APH; Cell Biology, Neurobiology and Biophysics, Department of Biology, Faculty of Science, Utrecht University, Utrecht, the Netherlands.
Scheefhals N; Cell Biology, Neurobiology and Biophysics, Department of Biology, Faculty of Science, Utrecht University, Utrecht, the Netherlands.
Mertens E; Cell Biology, Neurobiology and Biophysics, Department of Biology, Faculty of Science, Utrecht University, Utrecht, the Netherlands.
Catsburg LAE; Cell Biology, Neurobiology and Biophysics, Department of Biology, Faculty of Science, Utrecht University, Utrecht, the Netherlands.
Poorthuis RB; Department of Translational Neuroscience, UMC Utrecht Brain Center, Utrecht University, Utrecht, the Netherlands.
de Winter F; Laboratory for Neuroregeneration, Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences, Amsterdam, the Netherlands.
Verhaagen J; Laboratory for Neuroregeneration, Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences, Amsterdam, the Netherlands.
Meye FJ; Department of Translational Neuroscience, UMC Utrecht Brain Center, Utrecht University, Utrecht, the Netherlands.
MacGillavry HD; Cell Biology, Neurobiology and Biophysics, Department of Biology, Faculty of Science, Utrecht University, Utrecht, the Netherlands.
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Źródło:
PLoS biology [PLoS Biol] 2020 Apr 10; Vol. 18 (4), pp. e3000665. Date of Electronic Publication: 2020 Apr 10 (Print Publication: 2020).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
CRISPR-Cas Systems*
Epitopes/*genetics
Gene Editing/*methods
Neurons/*immunology
Proteins/*genetics
Animals ; Cells, Cultured ; Dependovirus/genetics ; Female ; Gene Knock-In Techniques ; Genes, Reporter ; Genetic Vectors ; Genome ; Green Fluorescent Proteins/genetics ; Green Fluorescent Proteins/metabolism ; Male ; Mice, Transgenic ; Microscopy, Fluorescence ; Molecular Imaging/methods ; Neurons/physiology ; Organ Culture Techniques ; Proteins/immunology ; Proteins/metabolism ; Rats, Wistar ; Receptors, N-Methyl-D-Aspartate/genetics ; Receptors, N-Methyl-D-Aspartate/metabolism ; Spatio-Temporal Analysis
Czasopismo naukowe
Tytuł:
Chinese families with autosomal recessive hereditary spastic paraplegia caused by mutations in SPG11.
Autorzy:
Chen X; Department of Neurology, West China Hospital, Sichuan University, No. 37 Guoxue Xiang, Chengdu, 610041, Sichuan, China.
Liu J; Department of Neurology, West China Hospital, Sichuan University, No. 37 Guoxue Xiang, Chengdu, 610041, Sichuan, China.
Wei QQ; Department of Neurology, West China Hospital, Sichuan University, No. 37 Guoxue Xiang, Chengdu, 610041, Sichuan, China.
Ou RW; Department of Neurology, West China Hospital, Sichuan University, No. 37 Guoxue Xiang, Chengdu, 610041, Sichuan, China.
Cao B; Department of Neurology, West China Hospital, Sichuan University, No. 37 Guoxue Xiang, Chengdu, 610041, Sichuan, China.
Yuan X; Department of Neurology, West China Hospital, Sichuan University, No. 37 Guoxue Xiang, Chengdu, 610041, Sichuan, China.
Hou Y; Department of Neurology, West China Hospital, Sichuan University, No. 37 Guoxue Xiang, Chengdu, 610041, Sichuan, China.
Zhang L; Department of Neurology, West China Hospital, Sichuan University, No. 37 Guoxue Xiang, Chengdu, 610041, Sichuan, China.
Shang H; Department of Neurology, West China Hospital, Sichuan University, No. 37 Guoxue Xiang, Chengdu, 610041, Sichuan, China. .
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Źródło:
BMC neurology [BMC Neurol] 2020 Jan 03; Vol. 20 (1), pp. 2. Date of Electronic Publication: 2020 Jan 03.
Typ publikacji:
Journal Article
MeSH Terms:
Spastic Paraplegia, Hereditary*/genetics
Spastic Paraplegia, Hereditary*/physiopathology
Asian People/*genetics
Genes, Recessive/*genetics
Proteins/*genetics
Adolescent ; Adult ; Child ; China ; Female ; Humans ; Male ; Mutation/genetics ; Young Adult
Czasopismo naukowe
Tytuł:
Dominant-negative mechanism of leukemogenic PAX5 fusions.
Autorzy:
Kawamata N; Hematology/Oncology, Cedars-Sinai Medical Center/UCLA School of Medicine, Los Angeles, CA, USA. />Pennella MA
Woo JL
Berk AJ
Koeffler HP
Pokaż więcej
Źródło:
Oncogene [Oncogene] 2012 Feb 23; Vol. 31 (8), pp. 966-77. Date of Electronic Publication: 2011 Jul 18.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Genes, Dominant*
Oncogene Proteins, Fusion/*metabolism
PAX5 Transcription Factor/*metabolism
Precursor Cell Lymphoblastic Leukemia-Lymphoma/*metabolism
Proteins/*metabolism
Cell Line ; Chromatin/metabolism ; DNA, Circular/chemistry ; Fluorescence Recovery After Photobleaching ; Gene Expression ; Genes, Reporter ; Humans ; Luciferases, Renilla/biosynthesis ; Luciferases, Renilla/genetics ; Oncogene Proteins, Fusion/genetics ; PAX5 Transcription Factor/chemistry ; PAX5 Transcription Factor/genetics ; Polydeoxyribonucleotides/chemistry ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/genetics ; Protein Binding ; Protein Interaction Domains and Motifs ; Protein Multimerization ; Proteins/chemistry ; Proteins/genetics
Czasopismo naukowe

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