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Title:
Glioblastoma-instructed microglia transition to heterogeneous phenotypic states with phagocytic and dendritic cell-like features in patient tumors and patient-derived orthotopic xenografts.
Authors:
Yabo YA; NORLUX Neuro-Oncology Laboratory, Department of Cancer Research, Luxembourg Institute of Health (LIH), L-1210, Luxembourg, Luxembourg.; Department of Life Sciences and Medicine, Faculty of Science, Technology and Medicine (FSTM), University of Luxembourg, L-4367, Belvaux, Luxembourg.
Moreno-Sanchez PM; NORLUX Neuro-Oncology Laboratory, Department of Cancer Research, Luxembourg Institute of Health (LIH), L-1210, Luxembourg, Luxembourg.; Department of Life Sciences and Medicine, Faculty of Science, Technology and Medicine (FSTM), University of Luxembourg, L-4367, Belvaux, Luxembourg.
Pires-Afonso Y; Department of Life Sciences and Medicine, Faculty of Science, Technology and Medicine (FSTM), University of Luxembourg, L-4367, Belvaux, Luxembourg.; Neuro-Immunology Group, Department of Cancer Research, Luxembourg Institute of Health, L-1210, Luxembourg, Luxembourg.
Kaoma T; Bioinformatics Platform, Department of Medical Informatics, Luxembourg Institute of Health, L-1445, Strassen, Luxembourg.
Nosirov B; NORLUX Neuro-Oncology Laboratory, Department of Cancer Research, Luxembourg Institute of Health (LIH), L-1210, Luxembourg, Luxembourg.; Multiomics Data Science, Department of Cancer Research, Luxembourg Institute of Health, L-1445, Strassen, Luxembourg.
Scafidi A; Department of Life Sciences and Medicine, Faculty of Science, Technology and Medicine (FSTM), University of Luxembourg, L-4367, Belvaux, Luxembourg.; Neuro-Immunology Group, Department of Cancer Research, Luxembourg Institute of Health, L-1210, Luxembourg, Luxembourg.
Ermini L; NORLUX Neuro-Oncology Laboratory, Department of Cancer Research, Luxembourg Institute of Health (LIH), L-1210, Luxembourg, Luxembourg.
Lipsa A; NORLUX Neuro-Oncology Laboratory, Department of Cancer Research, Luxembourg Institute of Health (LIH), L-1210, Luxembourg, Luxembourg.
Oudin A; NORLUX Neuro-Oncology Laboratory, Department of Cancer Research, Luxembourg Institute of Health (LIH), L-1210, Luxembourg, Luxembourg.
Kyriakis D; Department of Life Sciences and Medicine, Faculty of Science, Technology and Medicine (FSTM), University of Luxembourg, L-4367, Belvaux, Luxembourg.; Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, L-4362, Esch-sur-Alzette, Luxembourg.
Grzyb K; Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, L-4362, Esch-sur-Alzette, Luxembourg.
Poovathingal SK; Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, L-4362, Esch-sur-Alzette, Luxembourg.; Single Cell Analytics & Microfluidics Core, Vlaams Instituut Voor Biotechnologie-KU Leuven, 3000, Louvain, Belgium.
Poli A; Neuro-Immunology Group, Department of Cancer Research, Luxembourg Institute of Health, L-1210, Luxembourg, Luxembourg.
Muller A; Bioinformatics Platform, Department of Medical Informatics, Luxembourg Institute of Health, L-1445, Strassen, Luxembourg.
Toth R; Bioinformatics Platform, Department of Medical Informatics, Luxembourg Institute of Health, L-1445, Strassen, Luxembourg.; Multiomics Data Science, Department of Cancer Research, Luxembourg Institute of Health, L-1445, Strassen, Luxembourg.
Klink B; National Center of Genetics, Laboratoire National de Santé, L-3555, Dudelange, Luxembourg.; Department of Cancer Research, Luxembourg Institute of Health, L-1210, Luxembourg, Luxembourg.; German Cancer Consortium (DKTK): Core Unit for Molecular Tumor Diagnostics (CMTD), National Center for Tumor Diseases (NCT/UCC), Cancer Consortium (DKTK) Partner Site Dresden, and German Cancer Research Center (DKFZ), Dresden, Heidelberg, 01307, Germany.; Institute for Clinical Genetics, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, 01307, Dresden, Germany.
Berchem G; Department of Life Sciences and Medicine, Faculty of Science, Technology and Medicine (FSTM), University of Luxembourg, L-4367, Belvaux, Luxembourg.; Department of Cancer Research, Luxembourg Institute of Health, L-1210, Luxembourg, Luxembourg.; Centre Hospitalier Luxembourg, L-1210, Luxembourg, Luxembourg.
Berthold C; Centre Hospitalier Luxembourg, L-1210, Luxembourg, Luxembourg.
Hertel F; Centre Hospitalier Luxembourg, L-1210, Luxembourg, Luxembourg.
Mittelbronn M; Department of Life Sciences and Medicine, Faculty of Science, Technology and Medicine (FSTM), University of Luxembourg, L-4367, Belvaux, Luxembourg.; Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, L-4362, Esch-sur-Alzette, Luxembourg.; Department of Cancer Research, Luxembourg Institute of Health, L-1210, Luxembourg, Luxembourg.; Luxembourg Center of Neuropathology (LCNP), L-3555, Dudelange, Luxembourg.; National Center of Pathology (NCP), Laboratoire National de Santé, L-3555, Dudelange, Luxembourg.
Heiland DH; Translational Neurosurgery, Friedrich-Alexander University Erlangen Nuremberg, 91054, Erlangen, Germany.; Department of Neurosurgery, University Hospital Erlangen, Friedrich-Alexander University Erlangen Nuremberg, 91054, Erlangen, Germany.; Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.; Department of Neurosurgery, Medical Center, University of Freiburg, 79106, Freiburg, Germany.; German Cancer Consortium (DKTK), Partner Site Freiburg, 79106, Freiburg, Germany.
Skupin A; Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, L-4362, Esch-sur-Alzette, Luxembourg.; Department of Physics and Material Science, University Luxembourg, L-4367, Belvaux, Luxembourg.; Department of Neuroscience, University of California San Diego, La Jolla, CA, 92093, USA.
Nazarov PV; Bioinformatics Platform, Department of Medical Informatics, Luxembourg Institute of Health, L-1445, Strassen, Luxembourg.; Multiomics Data Science, Department of Cancer Research, Luxembourg Institute of Health, L-1445, Strassen, Luxembourg.
Niclou SP; NORLUX Neuro-Oncology Laboratory, Department of Cancer Research, Luxembourg Institute of Health (LIH), L-1210, Luxembourg, Luxembourg.; Department of Life Sciences and Medicine, Faculty of Science, Technology and Medicine (FSTM), University of Luxembourg, L-4367, Belvaux, Luxembourg.
Michelucci A; NORLUX Neuro-Oncology Laboratory, Department of Cancer Research, Luxembourg Institute of Health (LIH), L-1210, Luxembourg, Luxembourg. .; Neuro-Immunology Group, Department of Cancer Research, Luxembourg Institute of Health, L-1210, Luxembourg, Luxembourg. .; Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, L-4362, Esch-sur-Alzette, Luxembourg. .
Golebiewska A; NORLUX Neuro-Oncology Laboratory, Department of Cancer Research, Luxembourg Institute of Health (LIH), L-1210, Luxembourg, Luxembourg. .
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Source:
Genome medicine [Genome Med] 2024 Apr 02; Vol. 16 (1), pp. 51. Date of Electronic Publication: 2024 Apr 02.
Publication Type:
Journal Article
MeSH Terms:
Glioblastoma*/genetics
Glioblastoma*/metabolism
Brain Neoplasms*/genetics
Brain Neoplasms*/metabolism
Mice ; Animals ; Humans ; Microglia/metabolism ; Ecosystem ; Heterografts ; Phenotype ; Disease Models, Animal ; Dendritic Cells/metabolism ; Tumor Microenvironment/genetics
Academic Journal
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Title:
Potential diagnostic and drug target markers in glioblastoma.
Authors:
Ahsan H; Department of Bioinformatics and Biosciences, Faculty of Health and Life Sciences, Capital University of Science and Technology (CUST), Islamabad, 44000, Pakistan.
Asghar M; Department of Biology, Lund University, Lund, Sweden. .; Department of Healthcare Biotechnology, Atta-Ur-Rahman School of Applied Biosciences (ASAB), National University of Sciences and Technology (NUST), Islamabad, H-12, Pakistan. .
Malik SI; Department of Bioinformatics and Biosciences, Faculty of Health and Life Sciences, Capital University of Science and Technology (CUST), Islamabad, 44000, Pakistan. .
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Source:
Scientific reports [Sci Rep] 2024 Mar 27; Vol. 14 (1), pp. 7292. Date of Electronic Publication: 2024 Mar 27.
Publication Type:
Journal Article
MeSH Terms:
Glioblastoma*/drug therapy
Glioblastoma*/genetics
Glioblastoma*/metabolism
Nisin*/metabolism
Brain Neoplasms*/drug therapy
Brain Neoplasms*/genetics
Adult ; Humans ; Janus Kinases/metabolism ; Proteomics ; Signal Transduction ; STAT Transcription Factors/metabolism ; Granulocyte Colony-Stimulating Factor/metabolism ; Gene Expression Regulation, Neoplastic
Academic Journal
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Title:
Integrative multi-omics characterization reveals sex differences in glioblastoma.
Authors:
Jang B; Department of Biomedical Informatics, Korea University College of Medicine, Seoul, South Korea.; Department of Biomedical Sciences, Korea University College of Medicine, Seoul, South Korea.
Yoon D; Department of Biomedical Informatics, Korea University College of Medicine, Seoul, South Korea.; Department of Biomedical Sciences, Korea University College of Medicine, Seoul, South Korea.
Lee JY; Department of Biomedical Informatics, Korea University College of Medicine, Seoul, South Korea.; Department of Biomedical Sciences, Korea University College of Medicine, Seoul, South Korea.
Kim J; Department of Biomedical Informatics, Korea University College of Medicine, Seoul, South Korea.; Department of Biomedical Sciences, Korea University College of Medicine, Seoul, South Korea.
Hong J; Department of Biomedical Informatics, Korea University College of Medicine, Seoul, South Korea.; Department of Biomedical Sciences, Korea University College of Medicine, Seoul, South Korea.
Koo H; Department of Biomedical Informatics, Korea University College of Medicine, Seoul, South Korea.; Department of Biomedical Sciences, Korea University College of Medicine, Seoul, South Korea.; Department of Cancer Biomedical Science, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang, South Korea.; Department of Clinical Research, Research Institute and Hospital, National Cancer Center, Goyang, South Korea.
Sa JK; Department of Biomedical Informatics, Korea University College of Medicine, Seoul, South Korea. .; Department of Biomedical Sciences, Korea University College of Medicine, Seoul, South Korea. .
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Source:
Biology of sex differences [Biol Sex Differ] 2024 Mar 16; Vol. 15 (1), pp. 23. Date of Electronic Publication: 2024 Mar 16.
Publication Type:
Journal Article
MeSH Terms:
Glioblastoma*/genetics
Glioblastoma*/metabolism
Glioblastoma*/pathology
Brain Neoplasms*/genetics
Brain Neoplasms*/metabolism
Brain Neoplasms*/pathology
Adult ; Humans ; Male ; Female ; Proteomics ; Multiomics ; Sex Characteristics ; ErbB Receptors ; Genomic Instability ; Aneuploidy
Academic Journal
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Title:
Exploring Regorafenib Responsiveness and Uncovering Molecular Mechanisms in Recurrent Glioblastoma Tumors through Longitudinal In Vitro Sampling.
Authors:
Morelli M; Fondazione Pisana per la Scienza, San Giuliano Terme, 56017 Pisa, Italy.
Lessi F; Fondazione Pisana per la Scienza, San Giuliano Terme, 56017 Pisa, Italy.
Franceschi S; Fondazione Pisana per la Scienza, San Giuliano Terme, 56017 Pisa, Italy.
Ferri G; Fondazione Pisana per la Scienza, San Giuliano Terme, 56017 Pisa, Italy.
Giacomarra M; Fondazione Pisana per la Scienza, San Giuliano Terme, 56017 Pisa, Italy.
Menicagli M; Fondazione Pisana per la Scienza, San Giuliano Terme, 56017 Pisa, Italy.
Gambacciani C; Neurosurgical Department of Spedali Riuniti di Livorno, 57124 Livorno, Italy.
Pieri F; Neurosurgical Department of Spedali Riuniti di Livorno, 57124 Livorno, Italy.
Pasqualetti F; Radiotherapy Department, Azienda Ospedaliera Universitaria Pisana, 56126 Pisa, Italy.
Montemurro N; Department of Neurosurgery, Azienda Ospedaliera Universitaria Pisana, 56126 Pisa, Italy.
Aretini P; Fondazione Pisana per la Scienza, San Giuliano Terme, 56017 Pisa, Italy.
Santonocito OS; Neurosurgical Department of Spedali Riuniti di Livorno, 57124 Livorno, Italy.
Di Stefano AL; Neurosurgical Department of Spedali Riuniti di Livorno, 57124 Livorno, Italy.
Mazzanti CM; Fondazione Pisana per la Scienza, San Giuliano Terme, 56017 Pisa, Italy.
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Source:
Cells [Cells] 2024 Mar 11; Vol. 13 (6). Date of Electronic Publication: 2024 Mar 11.
Publication Type:
Journal Article
MeSH Terms:
Glioblastoma*/drug therapy
Glioblastoma*/pathology
Phenylurea Compounds*
Pyridines*
Humans ; Antineoplastic Agents, Alkylating/pharmacology ; Neoplasm Recurrence, Local/pathology ; Temozolomide/pharmacology
Academic Journal
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Title:
TGF-β-activated circRYK drives glioblastoma progression by increasing VLDLR mRNA expression and stability in a ceRNA- and RBP-dependent manner.
Authors:
Wang Y; Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, 210000, China.
Wang B; Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, 210000, China.
Cao W; Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, 210000, China. .
Xu X; Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, 210000, China. .
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Source:
Journal of experimental & clinical cancer research : CR [J Exp Clin Cancer Res] 2024 Mar 08; Vol. 43 (1), pp. 73. Date of Electronic Publication: 2024 Mar 08.
Publication Type:
Journal Article
MeSH Terms:
MicroRNAs*/metabolism
Glioblastoma*/genetics
Glioblastoma*/metabolism
Humans ; Transforming Growth Factor beta/genetics ; Transforming Growth Factor beta/metabolism ; RNA, Competitive Endogenous ; RNA, Circular ; Cell Line, Tumor ; RNA, Messenger/genetics ; Cell Proliferation/genetics ; Gene Expression Regulation, Neoplastic ; Cell Movement/genetics
Academic Journal
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Title:
p53/E2F7 axis promotes temozolomide chemoresistance in glioblastoma multiforme.
Authors:
Meng J; Department of Laboratory Medicine, Wuxi People's Hospital, Wuxi Medical Center, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Nanjing Medical University, 214023, Wuxi, Jiangsu, China.; Center of Clinical Research, Wuxi People's Hospital, Wuxi Medical Center, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Nanjing Medical University, 214023, Wuxi, Jiangsu, China.
Qian W; Department of Laboratory Medicine, Wuxi People's Hospital, Wuxi Medical Center, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Nanjing Medical University, 214023, Wuxi, Jiangsu, China.; Center of Clinical Research, Wuxi People's Hospital, Wuxi Medical Center, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Nanjing Medical University, 214023, Wuxi, Jiangsu, China.; Department of Clinical Laborator, Kunshan Hospital of Traditional Chinese Medicine, Kunshan, 215300, Suzhou, Jiangsu, China.
Yang Z; Department of Laboratory Medicine, Wuxi People's Hospital, Wuxi Medical Center, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Nanjing Medical University, 214023, Wuxi, Jiangsu, China.; Center of Clinical Research, Wuxi People's Hospital, Wuxi Medical Center, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Nanjing Medical University, 214023, Wuxi, Jiangsu, China.
Gong L; Department of Laboratory Medicine, Wuxi People's Hospital, Wuxi Medical Center, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Nanjing Medical University, 214023, Wuxi, Jiangsu, China.; Center of Clinical Research, Wuxi People's Hospital, Wuxi Medical Center, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Nanjing Medical University, 214023, Wuxi, Jiangsu, China.
Xu D; Department of Laboratory Medicine, Wuxi People's Hospital, Wuxi Medical Center, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Nanjing Medical University, 214023, Wuxi, Jiangsu, China.; Center of Clinical Research, Wuxi People's Hospital, Wuxi Medical Center, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Nanjing Medical University, 214023, Wuxi, Jiangsu, China.
Huang H; NHC Key Laboratory of Nuclear Medicine, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, 214063, Wuxi, China.
Jiang X; Department of Laboratory Medicine, Wuxi People's Hospital, Wuxi Medical Center, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Nanjing Medical University, 214023, Wuxi, Jiangsu, China.; Center of Clinical Research, Wuxi People's Hospital, Wuxi Medical Center, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Nanjing Medical University, 214023, Wuxi, Jiangsu, China.
Pu Z; Department of Laboratory Medicine, Wuxi People's Hospital, Wuxi Medical Center, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Nanjing Medical University, 214023, Wuxi, Jiangsu, China. .; Center of Clinical Research, Wuxi People's Hospital, Wuxi Medical Center, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Nanjing Medical University, 214023, Wuxi, Jiangsu, China. .
Yin Y; Department of Laboratory Medicine, Wuxi People's Hospital, Wuxi Medical Center, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Nanjing Medical University, 214023, Wuxi, Jiangsu, China. .; Center of Clinical Research, Wuxi People's Hospital, Wuxi Medical Center, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Nanjing Medical University, 214023, Wuxi, Jiangsu, China. .
Zou J; Department of Laboratory Medicine, Wuxi People's Hospital, Wuxi Medical Center, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Nanjing Medical University, 214023, Wuxi, Jiangsu, China. .; Center of Clinical Research, Wuxi People's Hospital, Wuxi Medical Center, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Nanjing Medical University, 214023, Wuxi, Jiangsu, China. .
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Source:
BMC cancer [BMC Cancer] 2024 Mar 07; Vol. 24 (1), pp. 317. Date of Electronic Publication: 2024 Mar 07.
Publication Type:
Journal Article
MeSH Terms:
Brain Neoplasms*/drug therapy
Brain Neoplasms*/genetics
Brain Neoplasms*/pathology
Glioblastoma*/drug therapy
Glioblastoma*/genetics
Glioblastoma*/metabolism
Humans ; Antineoplastic Agents, Alkylating/pharmacology ; Antineoplastic Agents, Alkylating/therapeutic use ; Cell Line, Tumor ; Drug Resistance, Neoplasm/genetics ; E2F7 Transcription Factor/metabolism ; Prognosis ; Temozolomide/pharmacology ; Temozolomide/therapeutic use ; Tumor Suppressor Protein p53/genetics
Academic Journal
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Title:
Identification of TMZ resistance-associated histone post-translational modifications in glioblastoma using multi-omics data.
Authors:
Ye L; Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Gu L; Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Wang Y; Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Xing H; Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Li P; Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Guo X; Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Wang Y; Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Ma W; Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
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Source:
CNS neuroscience & therapeutics [CNS Neurosci Ther] 2024 Mar; Vol. 30 (3), pp. e14649.
Publication Type:
Journal Article
MeSH Terms:
Glioblastoma*/drug therapy
Glioblastoma*/genetics
Humans ; Temozolomide/pharmacology ; Temozolomide/therapeutic use ; Histones ; Multiomics ; Protein Processing, Post-Translational ; Sp1 Transcription Factor
Academic Journal
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Title:
Epigenetic remodeling to improve the efficacy of immunotherapy in human glioblastoma: pre-clinical evidence for development of new immunotherapy approaches.
Authors:
Lofiego MF; University of Siena, Siena, Italy.
Piazzini F; University of Siena, Siena, Italy.
Caruso FP; BIOGEM Institute of Molecular Biology and Genetics, Ariano Irpino, Italy.; Department of Electrical Engineering and Information Technology (DIETI), University of Naples 'Federico II', Naples, Italy.
Marzani F; University of Siena, Siena, Italy.
Solmonese L; Center for Immuno-Oncology, University Hospital of Siena, Siena, Italy.
Bello E; University of Siena, Siena, Italy.
Celesti F; University of Siena, Siena, Italy.
Costa MC; BIOGEM Institute of Molecular Biology and Genetics, Ariano Irpino, Italy.; Department of Electrical Engineering and Information Technology (DIETI), University of Naples 'Federico II', Naples, Italy.
Noviello T; BIOGEM Institute of Molecular Biology and Genetics, Ariano Irpino, Italy.; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL, USA.; Department of Public Health Sciences, Miller School of Medicine, University of Miami, Miami, FL, USA.
Mortarini R; Human Tumors Immunobiology Unit, Department of Research, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
Anichini A; Human Tumors Immunobiology Unit, Department of Research, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
Ceccarelli M; BIOGEM Institute of Molecular Biology and Genetics, Ariano Irpino, Italy.; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL, USA.; Department of Public Health Sciences, Miller School of Medicine, University of Miami, Miami, FL, USA.
Coral S; University of Siena, Siena, Italy.
Di Giacomo AM; University of Siena, Siena, Italy.; Center for Immuno-Oncology, University Hospital of Siena, Siena, Italy.
Maio M; University of Siena, Siena, Italy.; Center for Immuno-Oncology, University Hospital of Siena, Siena, Italy.
Covre A; University of Siena, Siena, Italy. .
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Corporate Authors:
EPigenetic Immune-oncology Consortium Airc (EPICA) investigators
Source:
Journal of translational medicine [J Transl Med] 2024 Mar 01; Vol. 22 (1), pp. 223. Date of Electronic Publication: 2024 Mar 01.
Publication Type:
Journal Article
MeSH Terms:
Glioblastoma*/genetics
Glioblastoma*/therapy
Glioblastoma*/metabolism
Azacitidine/*analogs & derivatives
Humans ; Azacitidine/therapeutic use ; Epigenesis, Genetic ; Immunotherapy
Academic Journal
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Title:
Glioblastoma and its treatment are associated with extensive accelerated brain aging.
Authors:
Ainslie AP; Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.; Department of Biomedical Sciences of Cells and Systems, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.; European Research Institute for the Biology of Ageing, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Klaver M; Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.; Department of Biomedical Sciences of Cells and Systems, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.; European Research Institute for the Biology of Ageing, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Voshart DC; Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.; Department of Biomedical Sciences of Cells and Systems, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Gerrits E; Department of Biomedical Sciences of Cells and Systems, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
den Dunnen WFA; Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Eggen BJL; Department of Biomedical Sciences of Cells and Systems, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Bergink S; Department of Biomedical Sciences of Cells and Systems, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.; University College Groningen, University of Groningen, Groningen, The Netherlands.
Barazzuol L; Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.; Department of Biomedical Sciences of Cells and Systems, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
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Source:
Aging cell [Aging Cell] 2024 Mar; Vol. 23 (3), pp. e14066. Date of Electronic Publication: 2024 Jan 17.
Publication Type:
Journal Article
MeSH Terms:
Glioblastoma*/genetics
Glioblastoma*/metabolism
Glioblastoma*/pathology
Alzheimer Disease*/pathology
Humans ; Quality of Life ; Brain/metabolism ; Aging/genetics ; Aging/pathology
Academic Journal
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Title:
Spatially Resolved Microglia/Macrophages in Recurrent Glioblastomas Overexpress Fatty Acid Metabolism and Phagocytic Genes.
Authors:
Mistry AM; Department of Neurosurgery, University of Louisville, Louisville, KY 40202, USA.; Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA.
Daneshmand J; Department of Bioinformatics, University of Louisville, Louisville, KY 40202, USA.
Seo SJ; Department of Neurosurgery, University of Louisville, Louisville, KY 40202, USA.
Lehman NL; Departments of Pathology and Laboratory Medicine, University of Louisville, Louisville, KY 40202, USA.
Miller DM; Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA.; Department of Medicine, University of Louisville, Louisville, KY 40202, USA.
Goodin DA; Department of Bioengineering, University of Louisville, Louisville, KY 40202, USA.
Frieboes HB; Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA.; Department of Bioengineering, University of Louisville, Louisville, KY 40202, USA.
Chen J; Department of Bioengineering, University of Louisville, Louisville, KY 40202, USA.
Masters A; Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA.; Department of Radiation Oncology, University of Louisville, Louisville, KY 40202, USA.
Williams BJ; Department of Neurosurgery, University of Louisville, Louisville, KY 40202, USA.; Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA.
Yaddanapudi K; Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA.; Department of Microbiology and Immunology, University of Louisville, Louisville, KY 40202, USA.; Department of Surgery, University of Louisville, Louisville, KY 40202, USA.
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Source:
Current oncology (Toronto, Ont.) [Curr Oncol] 2024 Feb 23; Vol. 31 (3), pp. 1183-1194. Date of Electronic Publication: 2024 Feb 23.
Publication Type:
Journal Article
MeSH Terms:
Glioblastoma*/genetics
Glioblastoma*/metabolism
Glioblastoma*/pathology
Brain Neoplasms*/pathology
Humans ; Microglia/metabolism ; Microglia/pathology ; Neoplasm Recurrence, Local/pathology ; Macrophages/metabolism ; Macrophages/pathology ; Fatty Acids/metabolism
Academic Journal
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Title:
Use of microRNAs as Diagnostic, Prognostic, and Therapeutic Tools for Glioblastoma.
Authors:
Valle-Garcia D; Laboratorio de Neuroinmunología, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez (INNNMVS), Mexico City 14269, Mexico.
Pérez de la Cruz V; Laboratorio de Neurobioquímica y Conducta, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez (INNNMVS), Mexico City 14269, Mexico.
Flores I; Laboratorio de Neuroinmunología, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez (INNNMVS), Mexico City 14269, Mexico.
Salazar A; Laboratorio de Neuroinmunología, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez (INNNMVS), Mexico City 14269, Mexico.
Pineda B; Laboratorio de Neuroinmunología, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez (INNNMVS), Mexico City 14269, Mexico.
Meza-Sosa KF; Laboratorio de Neurobioquímica y Conducta, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez (INNNMVS), Mexico City 14269, Mexico.
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Source:
International journal of molecular sciences [Int J Mol Sci] 2024 Feb 20; Vol. 25 (5). Date of Electronic Publication: 2024 Feb 20.
Publication Type:
Journal Article; Review
MeSH Terms:
MicroRNAs*/genetics
Glioblastoma*/pathology
Female ; Humans ; Prognosis ; Quality of Life ; Biomarkers
Academic Journal
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Title:
Antitumor Effects of Intravenous Natural Killer Cell Infusion in an Orthotopic Glioblastoma Xenograft Murine Model and Gene Expression Profile Analysis.
Authors:
Morimoto T; Department of Neurosurgery, Nara Medical University, Kashihara 634-8521, Nara, Japan.; Department of Neurosurgery, Nara City Hospital, Nara 630-8305, Nara, Japan.
Nakazawa T; Department of Neurosurgery, Nara Medical University, Kashihara 634-8521, Nara, Japan.; Department of Neurosurgery, Nara City Hospital, Nara 630-8305, Nara, Japan.
Matsuda R; Department of Neurosurgery, Nara Medical University, Kashihara 634-8521, Nara, Japan.
Maeoka R; Department of Neurosurgery, Nara Medical University, Kashihara 634-8521, Nara, Japan.
Nishimura F; Department of Neurosurgery, Nara Medical University, Kashihara 634-8521, Nara, Japan.
Nakamura M; Department of Neurosurgery, Nara Medical University, Kashihara 634-8521, Nara, Japan.; Grandsoul Research Institute for Immunology, Inc., Uda 633-2221, Nara, Japan.
Yamada S; Department of Neurosurgery, Nara Medical University, Kashihara 634-8521, Nara, Japan.
Park YS; Department of Neurosurgery, Nara Medical University, Kashihara 634-8521, Nara, Japan.
Tsujimura T; Grandsoul Research Institute for Immunology, Inc., Uda 633-2221, Nara, Japan.
Nakagawa I; Department of Neurosurgery, Nara Medical University, Kashihara 634-8521, Nara, Japan.
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Source:
International journal of molecular sciences [Int J Mol Sci] 2024 Feb 19; Vol. 25 (4). Date of Electronic Publication: 2024 Feb 19.
Publication Type:
Journal Article
MeSH Terms:
Glioblastoma*/therapy
Glioblastoma*/drug therapy
Brain Neoplasms*/therapy
Brain Neoplasms*/drug therapy
Humans ; Mice ; Animals ; Disease Models, Animal ; Transcriptome ; Heterografts ; Mice, Inbred NOD ; Killer Cells, Natural/metabolism ; Xenograft Model Antitumor Assays ; Cell Line, Tumor
Academic Journal
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Title:
In Vitro Glioblastoma Model on a Plate for Localized Drug Release Study from a 3D-Printed Drug-Eluted Hydrogel Mesh.
Authors:
Chehri B; Laboratory for Innovations in Microengineering (LiME), Department of Mechanical Engineering, University of Victoria, Victoria, BC V8P 5C2, Canada.
Liu K; Laboratory for Innovations in Microengineering (LiME), Department of Mechanical Engineering, University of Victoria, Victoria, BC V8P 5C2, Canada.
Vaseghi G; Laboratory for Innovations in Microengineering (LiME), Department of Mechanical Engineering, University of Victoria, Victoria, BC V8P 5C2, Canada.
Seyfoori A; Laboratory for Innovations in Microengineering (LiME), Department of Mechanical Engineering, University of Victoria, Victoria, BC V8P 5C2, Canada.
Akbari M; Laboratory for Innovations in Microengineering (LiME), Department of Mechanical Engineering, University of Victoria, Victoria, BC V8P 5C2, Canada.; Terasaki Institute for Biomedical Innovation, Los Angeles, CA 90064, USA.
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Source:
Cells [Cells] 2024 Feb 19; Vol. 13 (4). Date of Electronic Publication: 2024 Feb 19.
Publication Type:
Journal Article
MeSH Terms:
Glioblastoma*/drug therapy
Glioblastoma*/pathology
Humans ; Hydrogels/therapeutic use ; Drug Liberation ; Temozolomide/therapeutic use ; Printing, Three-Dimensional ; Tumor Microenvironment
Academic Journal
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Title:
Challenges and Promise for Glioblastoma Treatment through Extracellular Vesicle Inquiry.
Authors:
Liguori GL; Institute of Genetics and Biophysics (IGB) 'Adriano Buzzati-Traverso', National Research Council (CNR) of Italy, 80131 Naples, Italy.
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Source:
Cells [Cells] 2024 Feb 13; Vol. 13 (4). Date of Electronic Publication: 2024 Feb 13.
Publication Type:
Journal Article; Review
MeSH Terms:
Glioblastoma*/drug therapy
Glioblastoma*/pathology
Extracellular Vesicles*/pathology
Humans ; Quality of Life ; Neoplasm Recurrence, Local/pathology ; Temozolomide/therapeutic use
Academic Journal
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Title:
Integrated transcriptomics uncovers an enhanced association between the prion protein gene expression and vesicle dynamics signatures in glioblastomas.
Authors:
Boccacino JM; Department of Cell and Developmental Biology, Institute of Biomedical Sciences, University of São Paulo, Av. Prof. Lineu Prestes, 1524 room 431, Sao Paulo, 05508000, Brazil.
Dos Santos Peixoto R; Department of Automation and Systems, Technological Center, Federal University of Santa Catarina, Florianópolis, Santa Catarina, Brazil.
Fernandes CFL; Department of Cell and Developmental Biology, Institute of Biomedical Sciences, University of São Paulo, Av. Prof. Lineu Prestes, 1524 room 431, Sao Paulo, 05508000, Brazil.
Cangiano G; Department of Cell and Developmental Biology, Institute of Biomedical Sciences, University of São Paulo, Av. Prof. Lineu Prestes, 1524 room 431, Sao Paulo, 05508000, Brazil.
Sola PR; Cellular and Molecular Biology Laboratory (LIM 15), Department of Neurology, Faculdade de Medicina (FMUSP), University of Sao Paulo, Sao Paulo, Brazil.
Coelho BP; Department of Cell and Developmental Biology, Institute of Biomedical Sciences, University of São Paulo, Av. Prof. Lineu Prestes, 1524 room 431, Sao Paulo, 05508000, Brazil.
Prado MB; Department of Cell and Developmental Biology, Institute of Biomedical Sciences, University of São Paulo, Av. Prof. Lineu Prestes, 1524 room 431, Sao Paulo, 05508000, Brazil.
Melo-Escobar MI; Department of Cell and Developmental Biology, Institute of Biomedical Sciences, University of São Paulo, Av. Prof. Lineu Prestes, 1524 room 431, Sao Paulo, 05508000, Brazil.
de Sousa BP; Department of Cell and Developmental Biology, Institute of Biomedical Sciences, University of São Paulo, Av. Prof. Lineu Prestes, 1524 room 431, Sao Paulo, 05508000, Brazil.
Ayyadhury S; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.; The Donnelly Centre, University of Toronto, Toronto, Ontario, Canada.
Bader GD; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.; The Donnelly Centre, University of Toronto, Toronto, Ontario, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.; Department of Computer Science, University of Toronto, Toronto, Ontario, Canada.
Shinjo SMO; Cellular and Molecular Biology Laboratory (LIM 15), Department of Neurology, Faculdade de Medicina (FMUSP), University of Sao Paulo, Sao Paulo, Brazil.
Marie SKN; Cellular and Molecular Biology Laboratory (LIM 15), Department of Neurology, Faculdade de Medicina (FMUSP), University of Sao Paulo, Sao Paulo, Brazil.
da Rocha EL; Department of Microbiology, Immunology, and Parasitology, Biological Sciences Center, Federal University of Santa Catarina, Florianópolis, Santa Catarina, 88040-900, Brazil. .
Lopes MH; Department of Cell and Developmental Biology, Institute of Biomedical Sciences, University of São Paulo, Av. Prof. Lineu Prestes, 1524 room 431, Sao Paulo, 05508000, Brazil. .
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Source:
BMC cancer [BMC Cancer] 2024 Feb 13; Vol. 24 (1), pp. 199. Date of Electronic Publication: 2024 Feb 13.
Publication Type:
Journal Article
MeSH Terms:
Glioblastoma*/genetics
Glioblastoma*/pathology
Prions*/genetics
Prions*/metabolism
Humans ; Gene Expression ; Gene Expression Profiling ; Prion Proteins/genetics ; Prion Proteins/metabolism ; rab GTP-Binding Proteins/genetics ; Synaptophysin/metabolism
Academic Journal
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Title:
Betulinic Acid for Glioblastoma Treatment: Reality, Challenges and Perspectives.
Authors:
Fernandes S; Center for Translational Health and Medical Biotechnology Research (TBIO), School of Health (ESS), Polytechnic University of Porto, Rua Dr. António Bernardino de Almeida, 400, 4200-072 Porto, Portugal.; Center for Research on Health and Environment (CISA), School of Health (ESS), Polytechnic University of Porto, Rua Dr. António Bernardino de Almeida, 400, 4200-072 Porto, Portugal.
Vieira M; Center for Translational Health and Medical Biotechnology Research (TBIO), School of Health (ESS), Polytechnic University of Porto, Rua Dr. António Bernardino de Almeida, 400, 4200-072 Porto, Portugal.
Prudêncio C; Center for Translational Health and Medical Biotechnology Research (TBIO), School of Health (ESS), Polytechnic University of Porto, Rua Dr. António Bernardino de Almeida, 400, 4200-072 Porto, Portugal.; Ciências Químicas e das Biomoléculas, School of Health (ESS), Polytechnic University of Porto, Rua Dr. António Bernardino de Almeida, 400, 4200-072 Porto, Portugal.
Ferraz R; Center for Translational Health and Medical Biotechnology Research (TBIO), School of Health (ESS), Polytechnic University of Porto, Rua Dr. António Bernardino de Almeida, 400, 4200-072 Porto, Portugal.; Ciências Químicas e das Biomoléculas, School of Health (ESS), Polytechnic University of Porto, Rua Dr. António Bernardino de Almeida, 400, 4200-072 Porto, Portugal.; LAQV-REQUIMTE, Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade do Porto, Rua do Campo Alegre, 687, 4169-007 Porto, Portugal.
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Source:
International journal of molecular sciences [Int J Mol Sci] 2024 Feb 09; Vol. 25 (4). Date of Electronic Publication: 2024 Feb 09.
Publication Type:
Journal Article; Review
MeSH Terms:
Glioblastoma*/drug therapy
Glioblastoma*/pathology
Triterpenes*/pharmacology
Triterpenes*/therapeutic use
Triterpenes*/chemistry
Antineoplastic Agents*/pharmacology
Antineoplastic Agents*/therapeutic use
Antineoplastic Agents*/chemistry
Humans ; Pentacyclic Triterpenes/therapeutic use ; Betulinic Acid
Academic Journal
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Title:
Glut-3 Gene Knockdown as a Potential Strategy to Overcome Glioblastoma Radioresistance.
Authors:
Pucci G; Institute of Molecular Bioimaging and Physiology (IBFM)-National Research Council (CNR), Cefalù Secondary Site, C/da Pietrapollastra-Pisciotto, 90015 Cefalù, Italy.; Department of Biological, Chemical and Pharmaceutical Sciences and Technologies (STeBiCeF), University of Palermo, Viale delle Scienze Bld.17, 90128 Palermo, Italy.
Minafra L; Institute of Molecular Bioimaging and Physiology (IBFM)-National Research Council (CNR), Cefalù Secondary Site, C/da Pietrapollastra-Pisciotto, 90015 Cefalù, Italy.; Department of Biological, Chemical and Pharmaceutical Sciences and Technologies (STeBiCeF), University of Palermo, Viale delle Scienze Bld.17, 90128 Palermo, Italy.
Bravatà V; Institute of Molecular Bioimaging and Physiology (IBFM)-National Research Council (CNR), Cefalù Secondary Site, C/da Pietrapollastra-Pisciotto, 90015 Cefalù, Italy.
Calvaruso M; Institute of Molecular Bioimaging and Physiology (IBFM)-National Research Council (CNR), Cefalù Secondary Site, C/da Pietrapollastra-Pisciotto, 90015 Cefalù, Italy.
Turturici G; Department of Biological, Chemical and Pharmaceutical Sciences and Technologies (STeBiCeF), University of Palermo, Viale delle Scienze Bld.17, 90128 Palermo, Italy.
Cammarata FP; Institute of Molecular Bioimaging and Physiology (IBFM)-National Research Council (CNR), Cefalù Secondary Site, C/da Pietrapollastra-Pisciotto, 90015 Cefalù, Italy.
Savoca G; Radiation Oncology, ARNAS-Civico Hospital, 90100 Palermo, Italy.
Abbate B; Radiation Oncology, ARNAS-Civico Hospital, 90100 Palermo, Italy.
Russo G; Institute of Molecular Bioimaging and Physiology (IBFM)-National Research Council (CNR), Cefalù Secondary Site, C/da Pietrapollastra-Pisciotto, 90015 Cefalù, Italy.
Cavalieri V; Department of Biological, Chemical and Pharmaceutical Sciences and Technologies (STeBiCeF), University of Palermo, Viale delle Scienze Bld.17, 90128 Palermo, Italy.
Forte GI; Institute of Molecular Bioimaging and Physiology (IBFM)-National Research Council (CNR), Cefalù Secondary Site, C/da Pietrapollastra-Pisciotto, 90015 Cefalù, Italy.; Department of Biological, Chemical and Pharmaceutical Sciences and Technologies (STeBiCeF), University of Palermo, Viale delle Scienze Bld.17, 90128 Palermo, Italy.
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Source:
International journal of molecular sciences [Int J Mol Sci] 2024 Feb 08; Vol. 25 (4). Date of Electronic Publication: 2024 Feb 08.
Publication Type:
Journal Article
MeSH Terms:
Glioblastoma*/genetics
Glioblastoma*/radiotherapy
Glioblastoma*/metabolism
Glucose Transporter Type 3*/genetics
Glucose Transporter Type 3*/metabolism
Humans ; Biomarkers/metabolism ; Cell Hypoxia/genetics ; Cell Line, Tumor ; Gene Knockdown Techniques ; Hypoxia
Academic Journal
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Title:
Transformed astrocytes confer temozolomide resistance on glioblastoma via delivering ALKBH7 to enhance APNG expression after educating by glioblastoma stem cells-derived exosomes.
Authors:
Liu X; Department of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Liu L; Department of Neurosurgery, Affiliated Nanjing Brain Hospital, Nanjing Medical University, Nanjing, Jiangsu, China.
Wu A; Department of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Huang S; Department of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Xu Z; Department of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Zhang X; Department of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Li Z; Department of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Li H; Department of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Dong J; Department of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou, China.
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Source:
CNS neuroscience & therapeutics [CNS Neurosci Ther] 2024 Feb; Vol. 30 (2), pp. e14599.
Publication Type:
Journal Article
MeSH Terms:
Glioblastoma*/pathology
Exosomes*/metabolism
Brain Neoplasms*/genetics
Adult ; Humans ; Temozolomide/pharmacology ; Temozolomide/therapeutic use ; Astrocytes/metabolism ; Stem Cells/metabolism ; Drug Resistance, Neoplasm ; Cell Line, Tumor ; Xenograft Model Antitumor Assays ; Antineoplastic Agents, Alkylating/pharmacology ; Antineoplastic Agents, Alkylating/therapeutic use ; AlkB Enzymes ; Mitochondrial Proteins
Academic Journal
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Title:
Comprehensive analysis of PSMD family members and validation of PSMD9 as a potential therapeutic target in human glioblastoma.
Authors:
Li Y; Department of Neurosurgery, Qilu Hospital, Cheeloo College of Medicine and Institute of Brain and Brain-Inspired Science, Shandong University, Jinan, China.; Jinan Microecological Biomedicine Shandong Laboratory and Shandong Key Laboratory of Brain Function Remodeling, Jinan, China.
Liu X; Department of Neurosurgery, Qilu Hospital, Cheeloo College of Medicine and Institute of Brain and Brain-Inspired Science, Shandong University, Jinan, China.; Jinan Microecological Biomedicine Shandong Laboratory and Shandong Key Laboratory of Brain Function Remodeling, Jinan, China.
Zhao F; Department of Neurosurgery, Qilu Hospital, Cheeloo College of Medicine and Institute of Brain and Brain-Inspired Science, Shandong University, Jinan, China.; Jinan Microecological Biomedicine Shandong Laboratory and Shandong Key Laboratory of Brain Function Remodeling, Jinan, China.
Zhao Z; Department of Neurosurgery, Qilu Hospital, Cheeloo College of Medicine and Institute of Brain and Brain-Inspired Science, Shandong University, Jinan, China.; Jinan Microecological Biomedicine Shandong Laboratory and Shandong Key Laboratory of Brain Function Remodeling, Jinan, China.
Li X; Department of Neurosurgery, Qilu Hospital, Cheeloo College of Medicine and Institute of Brain and Brain-Inspired Science, Shandong University, Jinan, China.; Jinan Microecological Biomedicine Shandong Laboratory and Shandong Key Laboratory of Brain Function Remodeling, Jinan, China.
Wang J; Department of Neurosurgery, Qilu Hospital, Cheeloo College of Medicine and Institute of Brain and Brain-Inspired Science, Shandong University, Jinan, China.; Jinan Microecological Biomedicine Shandong Laboratory and Shandong Key Laboratory of Brain Function Remodeling, Jinan, China.; Department of Biomedicine, University of Bergen, Bergen, Norway.
Huang B; Department of Neurosurgery, Qilu Hospital, Cheeloo College of Medicine and Institute of Brain and Brain-Inspired Science, Shandong University, Jinan, China.; Jinan Microecological Biomedicine Shandong Laboratory and Shandong Key Laboratory of Brain Function Remodeling, Jinan, China.
Chen A; Department of Neurosurgery, Qilu Hospital, Cheeloo College of Medicine and Institute of Brain and Brain-Inspired Science, Shandong University, Jinan, China.; Jinan Microecological Biomedicine Shandong Laboratory and Shandong Key Laboratory of Brain Function Remodeling, Jinan, China.
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Source:
CNS neuroscience & therapeutics [CNS Neurosci Ther] 2024 Feb; Vol. 30 (2), pp. e14366. Date of Electronic Publication: 2023 Jul 23.
Publication Type:
Journal Article
MeSH Terms:
Glioblastoma*/drug therapy
Glioblastoma*/genetics
Glioblastoma*/metabolism
Brain Neoplasms*/drug therapy
Brain Neoplasms*/genetics
Brain Neoplasms*/metabolism
Glioma*/genetics
Humans ; Panobinostat ; Cell Line, Tumor ; Prognosis ; Transcription Factors/genetics ; RNA, Messenger/metabolism ; Gene Expression Regulation, Neoplastic ; Proteasome Endopeptidase Complex/genetics ; Proteasome Endopeptidase Complex/metabolism
Academic Journal
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Title:
MiR-4524b-5p-targeting ALDH1A3 attenuates the proliferation and radioresistance of glioblastoma via PI3K/AKT/mTOR signaling.
Authors:
Yu H; Department of Neurosurgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.; Center of Brain Science, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Li X; Department of Neurosurgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.; Center of Brain Science, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Li Y; Department of Radiotherapy, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Wang T; Department of Neurosurgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Wang M; Department of Neurosurgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Mao P; Department of Neurosurgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.; Center of Brain Science, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
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Source:
CNS neuroscience & therapeutics [CNS Neurosci Ther] 2024 Feb; Vol. 30 (2), pp. e14396. Date of Electronic Publication: 2023 Aug 08.
Publication Type:
Journal Article
MeSH Terms:
Glioblastoma*/genetics
Glioblastoma*/radiotherapy
Glioblastoma*/metabolism
MicroRNAs*/genetics
MicroRNAs*/metabolism
Humans ; Proto-Oncogene Proteins c-akt/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Cell Line, Tumor ; Cell Proliferation/genetics ; TOR Serine-Threonine Kinases/metabolism ; Gene Expression Regulation, Neoplastic
Academic Journal
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