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Tytuł :
Predictive significance of HER2 intratumoral heterogeneity, determined by simultaneous gene and protein analysis, for resistance to trastuzumab-based treatments for HER2-positive breast cancer.
Autorzy :
Horii R; Division of Pathology, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan. .; Department of Pathology, Saitama Cancer Center, 780 Komuro, Ina, Kita-adachi-gun, Saitama, 362-0806, Japan. .
Nitta H; Roche Tissue Diagnostics, Tucson, AZ, USA.
Nojima M; Center for Translational Research, The Institute of Medical Science Hospital, The University of Tokyo, Tokyo, Japan.
Maruyama R; Project for Cancer Epigenomics, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan.
Ueno T; Breast Oncology Center, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan.
Ito Y; Breast Oncology Center, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan.
Ohno S; Breast Oncology Center, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan.
Banks P; Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Kanda H; Division of Pathology, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan.; Department of Pathology, Saitama Cancer Center, 780 Komuro, Ina, Kita-adachi-gun, Saitama, 362-0806, Japan.
Akiyama F; Division of Pathology, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan.
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Źródło :
Virchows Archiv : an international journal of pathology [Virchows Arch] 2021 Jul; Vol. 479 (1), pp. 13-21. Date of Electronic Publication: 2021 Jan 26.
Typ publikacji :
Journal Article
MeSH Terms :
Genetic Heterogeneity*
Antineoplastic Agents, Immunological/*therapeutic use
Biomarkers, Tumor/*genetics
Breast Neoplasms/*drug therapy
Drug Resistance, Neoplasm/*genetics
Receptor, ErbB-2/*genetics
Trastuzumab/*therapeutic use
Adult ; Aged ; Biomarkers, Tumor/antagonists & inhibitors ; Biomarkers, Tumor/metabolism ; Breast Neoplasms/enzymology ; Breast Neoplasms/genetics ; Breast Neoplasms/pathology ; Female ; Gene Amplification ; Gene Expression Regulation, Neoplastic ; Humans ; Immunohistochemistry ; In Situ Hybridization ; Middle Aged ; Predictive Value of Tests ; Receptor, ErbB-2/antagonists & inhibitors ; Receptor, ErbB-2/metabolism
Czasopismo naukowe
Tytuł :
Measuring expression heterogeneity of single-cell cytoskeletal protein complexes.
Autorzy :
Vlassakis J; Department of Bioengineering, University of California Berkeley, Berkeley, CA, USA.
Hansen LL; Department of Bioengineering, University of California Berkeley, Berkeley, CA, USA.
Higuchi-Sanabria R; Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, CA, USA.
Zhou Y; Division of Biostatistics, University of California Berkeley, Berkeley, CA, USA.
Tsui CK; Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, CA, USA.
Dillin A; Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, CA, USA.; Howard Hughes Medical Institute, University of California Berkeley, Berkeley, CA, USA.
Huang H; Department of Statistics, University of California Berkeley, Berkeley, CA, USA.; Center for Computational Biology, University of California Berkeley, Berkeley, CA, USA.
Herr AE; Department of Bioengineering, University of California Berkeley, Berkeley, CA, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Aug 17; Vol. 12 (1), pp. 4969. Date of Electronic Publication: 2021 Aug 17.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Genetic Heterogeneity*
Cytoskeletal Proteins/*genetics
Cytoskeletal Proteins/*metabolism
Cytoskeleton/*metabolism
Actins/genetics ; Actins/metabolism ; Animals ; Bridged Bicyclo Compounds, Heterocyclic/pharmacology ; Cell Differentiation ; Cell Line ; Heat-Shock Response ; Humans ; Microtubules/metabolism ; Models, Biological ; Single-Cell Analysis/methods ; Thiazolidines/pharmacology
Czasopismo naukowe
Tytuł :
Genome sequencing in families with congenital limb malformations.
Autorzy :
Elsner J; Institute of Medical Genetics and Human Genetics, Charité-Universitätsmedizin Berlin, Corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Mensah MA; Institute of Medical Genetics and Human Genetics, Charité-Universitätsmedizin Berlin, Corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany.
Holtgrewe M; Core Unit Bioinformatics, Berlin Institute of Health (BIH), Berlin, Germany.
Hertzberg J; Max Planck Institute for Molecular Genetics, RG Development and Disease, Berlin, Germany.
Bigoni S; Medical Genetics Unit, Department of Mother and Child, Ferrara Sant'Anna University Hospital, Ferrara, Italy.
Busche A; Institut Für Humangenetik, Universitätsklinikum Münster, Münster, Germany.
Coutelier M; Institute of Medical Genetics and Human Genetics, Charité-Universitätsmedizin Berlin, Corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; Department of Human Genetics, Faculty of Medicine, Jewish General Hospital, McGill University, Montreal, QC, Canada.
de Silva DC; Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka.
Elçioglu N; Department of Pediatric Genetics, Marmara University Medical School, Istanbul, Turkey.; Eastern Mediterranean University Medical School, Cyprus, Mersin 10, Turkey.
Filges I; Institut für Medizinische Genetik und Pathologie, Universitätsspital Basel, Basel, Switzerland.
Gerkes E; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Girisha KM; Department of Medical Genetics, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, India.
Graul-Neumann L; Institute of Medical Genetics and Human Genetics, Charité-Universitätsmedizin Berlin, Corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Jamsheer A; Department of Medical Genetics, Poznan University of Medical Sciences, Poznan, Poland.
Krawitz P; Institute for Genomic Statistics and Bioinformatics, University of Bonn, Bonn, Germany.
Kurth I; Institute of Human Genetics, Medical Faculty, RWTH Aachen University Hospital, Aachen, Germany.
Markus S; Fachärztin Für Humangenetik, Bischof-von-Henle-Straße 2a, Regensburg, Germany.
Megarbane A; Department of Human Genetics, Gilbert and Rose-Marie Chagoury School of Medicine, Lebanese American University, Byblos, Lebanon.
Reis A; Institute of Human Genetics, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
Reuter MS; Institute of Human Genetics, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
Svoboda D; Kinderhandchirurgie, Medizinische Fakultät Mannheim der Universität Heidelberg, Heidelberg, Germany.
Teller C; Synlab MVZ Bad Nauheim, Mondorfstr. 1761231, Bad Nauheim, Germany.
Tuysuz B; Department of Pediatric Genetics, Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, Istanbul, Turkey.
Türkmen S; Institute of Medical Genetics and Human Genetics, Charité-Universitätsmedizin Berlin, Corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; National Center of Genetics (NCG), Laboratoire National de Santé 1, Rue Louis Rech, 3555, Dudelange, Luxembourg.
Wilson M; Genetic Medicine, Children's Hospital at Westmead, Paediatrics and Child Health, Sydney, Australia.
Woitschach R; Institute of Human Genetics, University Medical Center Hamburg, Eppendorf, Germany.
Vater I; Institute of Human Genetics, University of Kiel, Kiel, Germany.
Caliebe A; Institute of Human Genetics, University of Kiel, Kiel, Germany.
Hülsemann W; Katholisches Kinderkrankenhaus Wilhelmstift, Hamburg, Germany.
Horn D; Institute of Medical Genetics and Human Genetics, Charité-Universitätsmedizin Berlin, Corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Mundlos S; Institute of Medical Genetics and Human Genetics, Charité-Universitätsmedizin Berlin, Corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany. .; Max Planck Institute for Molecular Genetics, RG Development and Disease, Berlin, Germany. .
Spielmann M; Max Planck Institute for Molecular Genetics, RG Development and Disease, Berlin, Germany. .; Institute of Human Genetics, University of Kiel, Kiel, Germany. .; Institute of Human Genetics, University of Lübeck, Lübeck, Germany. .
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Źródło :
Human genetics [Hum Genet] 2021 Aug; Vol. 140 (8), pp. 1229-1239. Date of Electronic Publication: 2021 Jun 22.
Typ publikacji :
Journal Article
MeSH Terms :
Genetic Heterogeneity*
Mutation*
Homeodomain Proteins/*genetics
Limb Deformities, Congenital/*genetics
Transcription Factors/*genetics
Ubiquitin-Activating Enzymes/*genetics
Base Sequence ; Cohort Studies ; DNA Copy Number Variations ; Gene Expression ; Genetic Testing ; Humans ; Infant ; Limb Deformities, Congenital/metabolism ; Limb Deformities, Congenital/pathology ; Male ; Pedigree ; Transcription Factors/deficiency ; Ubiquitin-Activating Enzymes/deficiency ; Whole Genome Sequencing
Czasopismo naukowe
Tytuł :
Dissecting spatial heterogeneity and the immune-evasion mechanism of CTCs by single-cell RNA-seq in hepatocellular carcinoma.
Autorzy :
Sun YF; Department of Liver Surgery & Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University; Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai, People's Republic of China.
Wu L; BGI-Shenzhen, Shenzhen, Beishan Industrial Zone, Shenzhen, China.; BGI Education Center, University of Chinese Academy of Sciences (UCAS), Shenzhen, China.; Shenzhen Key Laboratory of Single-cell Omics, BGI-Shenzhen, Shenzhen, China.
Liu SP; BGI-Shenzhen, Shenzhen, Beishan Industrial Zone, Shenzhen, China.; Shenzhen Key Laboratory of Single-cell Omics, BGI-Shenzhen, Shenzhen, China.
Jiang MM; BGI-Shenzhen, Shenzhen, Beishan Industrial Zone, Shenzhen, China.; State Key Laboratory of Bioelectronics, Southeast University, Nanjing, China.; School of Biological Science and Medical Engineering, Southeast University, Nanjing, China.
Hu B; Department of Liver Surgery & Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University; Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai, People's Republic of China.
Zhou KQ; Department of Liver Surgery & Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University; Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai, People's Republic of China.
Guo W; Department of Laboratory Medicine, Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China.
Xu Y; Department of Liver Surgery & Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University; Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai, People's Republic of China.
Zhong Y; BGI-Shenzhen, Shenzhen, Beishan Industrial Zone, Shenzhen, China.; Shenzhen Key Laboratory of Single-cell Omics, BGI-Shenzhen, Shenzhen, China.
Zhou XR; BGI-Shenzhen, Shenzhen, Beishan Industrial Zone, Shenzhen, China.; BGI Education Center, University of Chinese Academy of Sciences (UCAS), Shenzhen, China.
Zhang ZF; Department of Liver Surgery & Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University; Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai, People's Republic of China.
Liu G; BGI-Shenzhen, Shenzhen, Beishan Industrial Zone, Shenzhen, China.
Liu S; BGI-Shenzhen, Shenzhen, Beishan Industrial Zone, Shenzhen, China.; BGI Education Center, University of Chinese Academy of Sciences (UCAS), Shenzhen, China.
Shi YH; Department of Liver Surgery & Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University; Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai, People's Republic of China.
Ji Y; Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China.
Du M; Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China.
Li NN; BGI-Shenzhen, Shenzhen, Beishan Industrial Zone, Shenzhen, China.; Shenzhen Key Laboratory of Single-cell Omics, BGI-Shenzhen, Shenzhen, China.
Li GB; BGI-Shenzhen, Shenzhen, Beishan Industrial Zone, Shenzhen, China.; Shenzhen Key Laboratory of Single-cell Omics, BGI-Shenzhen, Shenzhen, China.
Zhao ZK; BGI-Shenzhen, Shenzhen, Beishan Industrial Zone, Shenzhen, China.
Huang XY; BGI-Shenzhen, Shenzhen, Beishan Industrial Zone, Shenzhen, China.
Xu LQ; BGI-Shenzhen, Shenzhen, Beishan Industrial Zone, Shenzhen, China.; Shenzhen Key Laboratory of Single-cell Omics, BGI-Shenzhen, Shenzhen, China.
Yu QC; BGI-Shenzhen, Shenzhen, Beishan Industrial Zone, Shenzhen, China.; Shenzhen Key Laboratory of Single-cell Omics, BGI-Shenzhen, Shenzhen, China.
Peng DH; Dunwill Med-Tech, Shanghai, China.
Qiu SJ; Department of Liver Surgery & Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University; Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai, People's Republic of China.
Sun HC; Department of Liver Surgery & Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University; Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai, People's Republic of China.
Dean M; Laboratory of Translational Genomics, Division of Cancer Epidemiology & Genetics, National Cancer Institute Gaithersburg, Rockville, MD, USA.
Wang XD; Zhongshan Hospital Institute of Clinical Science, Shanghai Institute of Clinical Bioinformatics, Fudan University Center for Clinical Bioinformatics, Shanghai, China.
Chung WY; Department of Hepatobiliary and Pancreatic Surgery, University Hospitals of Leicester NHS Trust, Leicester, UK.
Dennison AR; Department of Hepatobiliary and Pancreatic Surgery, University Hospitals of Leicester NHS Trust, Leicester, UK.
Zhou J; Department of Liver Surgery & Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University; Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai, People's Republic of China.; Zhong-Hua Precision Medical Center, Zhongshan Hospital, Fudan University-BGI, Shanghai, People's Republic of China.
Hou Y; Zhong-Hua Precision Medical Center, Zhongshan Hospital, Fudan University-BGI, Shanghai, People's Republic of China. .
Fan J; Department of Liver Surgery & Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University; Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai, People's Republic of China. .; Zhong-Hua Precision Medical Center, Zhongshan Hospital, Fudan University-BGI, Shanghai, People's Republic of China. .
Yang XR; Department of Liver Surgery & Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University; Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai, People's Republic of China. .
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Źródło :
Nature communications [Nat Commun] 2021 Jul 02; Vol. 12 (1), pp. 4091. Date of Electronic Publication: 2021 Jul 02.
Typ publikacji :
Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Genetic Heterogeneity*
Immune Evasion*
Carcinoma, Hepatocellular/*genetics
Carcinoma, Hepatocellular/*immunology
Liver Neoplasms/*genetics
Liver Neoplasms/*immunology
Neoplastic Cells, Circulating/*immunology
Aged ; Animals ; Biomarkers, Tumor/metabolism ; Cell Cycle ; Cell Line, Tumor ; Chemokine CCL5/metabolism ; Gene Expression Regulation, Neoplastic ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Middle Aged ; Neoplasm Metastasis ; Neoplastic Cells, Circulating/metabolism ; Prognosis ; RNA-Seq ; Transcriptome ; Tumor Microenvironment
Czasopismo naukowe
Tytuł :
Heterogeneity of congenital afibrinogenemia, from epidemiology to clinical consequences and management.
Autorzy :
Casini A; Division of Angiology and Hemostasis, University Hospitals of Geneva, Geneva, Switzerland; Faculty of Medicine, University of Geneva, Rue Gabrielle-Perret-Gentil 4, 1205 Geneva, Switzerland. Electronic address: .
Neerman-Arbez M; Department of Genetic Medicine and Development, Faculty of Medicine, University of Geneva, 1 Rue Michel Servet, 1211 Geneva, Switzerland. Electronic address: .
de Moerloose P; Faculty of Medicine, University of Geneva, Rue Gabrielle-Perret-Gentil 4, 1205 Geneva, Switzerland. Electronic address: .
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Źródło :
Blood reviews [Blood Rev] 2021 Jul; Vol. 48, pp. 100793. Date of Electronic Publication: 2020 Dec 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Genetic Heterogeneity*
Afibrinogenemia/*epidemiology
Afibrinogenemia/*etiology
Genetic Diseases, Inborn/*epidemiology
Afibrinogenemia/diagnosis ; Afibrinogenemia/therapy ; Animals ; Disease Management ; Disease Susceptibility ; Genetic Diseases, Inborn/diagnosis ; Genetic Diseases, Inborn/therapy ; Hemorrhage/diagnosis ; Hemorrhage/epidemiology ; Hemorrhage/etiology ; Hemorrhage/therapy ; Humans ; Public Health Surveillance ; Thrombosis/diagnosis ; Thrombosis/epidemiology ; Thrombosis/etiology
Czasopismo naukowe
Tytuł :
Deciphering transcriptional and functional heterogeneity in hematopoiesis with single-cell genomics.
Autorzy :
Martin-Rufino JD; Division of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston.; Broad Institute of MIT and Harvard.
Sankaran VG; Division of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston.; Broad Institute of MIT and Harvard.; Harvard Stem Cell Institute, Cambridge, Massachusetts, USA.
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Źródło :
Current opinion in hematology [Curr Opin Hematol] 2021 Jul 01; Vol. 28 (4), pp. 269-276.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Review
MeSH Terms :
Gene Expression Regulation, Developmental*
Genetic Heterogeneity*
Genomics*/methods
Single-Cell Analysis*/methods
Cell Differentiation/*genetics
Hematopoiesis/*genetics
Hematopoietic Stem Cells/*metabolism
Animals ; Gene Expression Profiling/methods ; Hematopoietic Stem Cells/cytology ; Humans ; In Situ Hybridization, Fluorescence ; Transcriptome
Czasopismo naukowe
Tytuł :
Higher Mutation Burden in High Proliferation Compartments of Heterogeneous Melanoma Tumors.
Autorzy :
Grzywa TM; Center for Preclinical Research, The Department of Methodology, Medical University of Warsaw, 1B Banacha Str., 02-097 Warsaw, Poland.; Doctoral School, Medical University of Warsaw, 61 Zwirki and Wigury Str., 02-091 Warsaw, Poland.; Department of Immunology, Medical University of Warsaw, 5 Nielubowicza Str., 02-097 Warsaw, Poland.
Koppolu AA; Department of Medical Genetics, Medical University of Warsaw, 3C Pawinskiego Str., 02-106 Warsaw, Poland.; Postgraduate School of Molecular Medicine, Medical University of Warsaw, 02-091 Warsaw, Poland.
Paskal W; Center for Preclinical Research, The Department of Methodology, Medical University of Warsaw, 1B Banacha Str., 02-097 Warsaw, Poland.
Klicka K; Center for Preclinical Research, The Department of Methodology, Medical University of Warsaw, 1B Banacha Str., 02-097 Warsaw, Poland.; Doctoral School, Medical University of Warsaw, 61 Zwirki and Wigury Str., 02-091 Warsaw, Poland.
Rydzanicz M; Department of Medical Genetics, Medical University of Warsaw, 3C Pawinskiego Str., 02-106 Warsaw, Poland.
Wejman J; Department of Pathology, Medical Center of Postgraduate Education, 00-416 Warsaw, Poland.
Płoski R; Department of Medical Genetics, Medical University of Warsaw, 3C Pawinskiego Str., 02-106 Warsaw, Poland.
Włodarski PK; Center for Preclinical Research, The Department of Methodology, Medical University of Warsaw, 1B Banacha Str., 02-097 Warsaw, Poland.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Apr 09; Vol. 22 (8). Date of Electronic Publication: 2021 Apr 09.
Typ publikacji :
Journal Article
MeSH Terms :
Alleles*
Genetic Heterogeneity*
Mutation*
Melanoma/*genetics
Melanoma/*pathology
Aged ; Aged, 80 and over ; Biomarkers, Tumor ; Cell Line, Tumor ; Cell Proliferation ; Female ; Genetic Variation ; High-Throughput Nucleotide Sequencing ; Humans ; Immunohistochemistry ; Male ; Neoplasm Staging ; Skin Neoplasms/genetics ; Skin Neoplasms/pathology
SCR Disease Name :
Melanoma, Cutaneous Malignant
Czasopismo naukowe
Tytuł :
A computational approach for detecting physiological homogeneity in the midst of genetic heterogeneity.
Autorzy :
Zhang P; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065, USA. Electronic address: .
Cobat A; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM UMR1163, Paris 75015, France; University of Paris, Imagine Institute, Paris 75015, France.
Lee YS; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065, USA.
Wu Y; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Bayrak CS; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Boccon-Gibod C; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065, USA.
Matuozzo D; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM UMR1163, Paris 75015, France; University of Paris, Imagine Institute, Paris 75015, France.
Lorenzo L; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM UMR1163, Paris 75015, France; University of Paris, Imagine Institute, Paris 75015, France.
Jain A; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Boucherit S; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM UMR1163, Paris 75015, France; University of Paris, Imagine Institute, Paris 75015, France.
Vallée L; Neuropediatric Department, Roger Salengro Hospital, Lille 59037, France.
Stüve B; Clinics of the City of Cologne gGmbH, Cologne 53323, Germany.
Chabrier S; CHU Saint-Étienne, French Centre for Pediatric Stroke, Saint-Étienne, France.
Casanova JL; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065, USA; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM UMR1163, Paris 75015, France; University of Paris, Imagine Institute, Paris 75015, France; Howard Hughes Medical Institute, New York, NY 10065, USA. Electronic address: .
Abel L; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065, USA; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM UMR1163, Paris 75015, France; University of Paris, Imagine Institute, Paris 75015, France.
Zhang SY; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065, USA; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM UMR1163, Paris 75015, France; University of Paris, Imagine Institute, Paris 75015, France.
Itan Y; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065, USA; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
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Źródło :
American journal of human genetics [Am J Hum Genet] 2021 Jun 03; Vol. 108 (6), pp. 1012-1025. Date of Electronic Publication: 2021 May 19.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Regulatory Networks*
Genetic Heterogeneity*
Genetic Predisposition to Disease*
Computational Biology/*methods
Encephalitis, Herpes Simplex/*genetics
Encephalitis, Herpes Simplex/*pathology
Fibroblasts/*immunology
Case-Control Studies ; Encephalitis, Herpes Simplex/immunology ; Fibroblasts/metabolism ; Humans ; Toll-Like Receptor 3/genetics ; Toll-Like Receptor 3/immunology ; Toll-Like Receptor 3/metabolism ; Whole Exome Sequencing
Czasopismo naukowe
Tytuł :
Global Distribution and Genetic Heterogeneity of Border Disease Virus.
Autorzy :
Righi C; Istituto Zooprofilattico Sperimentale dell'Umbria e delle Marche 'Togo Rosati', 06126 Perugia, Italy.
Petrini S; Istituto Zooprofilattico Sperimentale dell'Umbria e delle Marche 'Togo Rosati', 06126 Perugia, Italy.
Pierini I; Istituto Zooprofilattico Sperimentale dell'Umbria e delle Marche 'Togo Rosati', 06126 Perugia, Italy.
Giammarioli M; Istituto Zooprofilattico Sperimentale dell'Umbria e delle Marche 'Togo Rosati', 06126 Perugia, Italy.
De Mia GM; Istituto Zooprofilattico Sperimentale dell'Umbria e delle Marche 'Togo Rosati', 06126 Perugia, Italy.
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Źródło :
Viruses [Viruses] 2021 May 21; Vol. 13 (6). Date of Electronic Publication: 2021 May 21.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Genetic Heterogeneity*
Genetic Variation*
Border Disease/*epidemiology
Border Disease/*virology
Border disease virus/*genetics
Animals ; Border disease virus/classification ; Genome, Viral ; Genomics/methods ; Genotype ; Geography, Medical ; Global Health ; Host Specificity ; Host-Pathogen Interactions ; Phylogeny ; Ruminants/virology
Czasopismo naukowe
Tytuł :
Drivers of dynamic intratumor heterogeneity and phenotypic plasticity.
Autorzy :
Biswas A; Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey.
De S; Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey.
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Źródło :
American journal of physiology. Cell physiology [Am J Physiol Cell Physiol] 2021 May 01; Vol. 320 (5), pp. C750-C760. Date of Electronic Publication: 2021 Mar 03.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Review
MeSH Terms :
Cell Plasticity*
Genetic Heterogeneity*
Biomarkers, Tumor/*genetics
Neoplasms/*genetics
Neoplasms/*pathology
Animals ; Antineoplastic Agents/therapeutic use ; Drug Resistance, Neoplasm/genetics ; Epigenesis, Genetic ; Genetic Predisposition to Disease ; Humans ; Mutation ; Neoplasms/drug therapy ; Phenotype ; Tumor Microenvironment
Czasopismo naukowe
Tytuł :
Genome-Wide Analysis of Sex Disparities in the Genetic Architecture of Lung and Colorectal Cancers.
Autorzy :
Nazarian A; Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, NC 27705, USA.
Kulminski AM; Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, NC 27705, USA.
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Źródło :
Genes [Genes (Basel)] 2021 May 01; Vol. 12 (5). Date of Electronic Publication: 2021 May 01.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Genetic Heterogeneity*
Polymorphism, Single Nucleotide*
Colorectal Neoplasms/*genetics
Lung Neoplasms/*genetics
Adult ; Aged ; Female ; Gene Frequency ; Humans ; Male ; Middle Aged ; Sex Factors
Czasopismo naukowe
Tytuł :
Genetic and metabolic investigations for individuals with neurodevelopmental disorders: A survey of Canadian geneticists' practices.
Autorzy :
Carter MT; Department of Genetics, CHEO, Ottawa, Ontario, Canada.
Cloutier M; Department of Genetics, CHEO, Ottawa, Ontario, Canada.
Tsampalieros A; Clinical Research Unit, CHEO, Ottawa, Ontario, Canada.
Webster R; Clinical Research Unit, CHEO, Ottawa, Ontario, Canada.
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Źródło :
American journal of medical genetics. Part A [Am J Med Genet A] 2021 Jun; Vol. 185 (6), pp. 1757-1766. Date of Electronic Publication: 2021 Mar 15.
Typ publikacji :
Journal Article
MeSH Terms :
Genetic Heterogeneity*
Physicians*
Neurodevelopmental Disorders/*epidemiology
Neurodevelopmental Disorders/*genetics
Adult ; Canada/epidemiology ; Female ; Genetic Testing ; High-Throughput Nucleotide Sequencing ; Humans ; Male ; Middle Aged ; Neurodevelopmental Disorders/pathology ; Surveys and Questionnaires ; Whole Exome Sequencing
Czasopismo naukowe
Tytuł :
Genetic and non-genetic clonal diversity in cancer evolution.
Autorzy :
Black JRM; Cancer Genome Evolution Research Group, University College London Cancer Institute, London, UK.; Cancer Research UK Lung Cancer Center of Excellence, University College London Cancer Institute, London, UK.
McGranahan N; Cancer Genome Evolution Research Group, University College London Cancer Institute, London, UK. .; Cancer Research UK Lung Cancer Center of Excellence, University College London Cancer Institute, London, UK. .
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Źródło :
Nature reviews. Cancer [Nat Rev Cancer] 2021 Jun; Vol. 21 (6), pp. 379-392. Date of Electronic Publication: 2021 Mar 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Clonal Evolution*
Genetic Heterogeneity*
Genome, Human*
Transcriptome*
Neoplasms/*pathology
Tumor Microenvironment/*immunology
Disease Progression ; Humans ; Neoplasms/etiology
Czasopismo naukowe
Tytuł :
Clinical and Genetic Heterogeneity in a Large Family with Pseudoxanthoma Elasticum: MTHFR and SERPINE1 Variants as Possible Disease Modifiers in Developing Ischemic Stroke.
Autorzy :
Bruno G; Division of Neurology, Department of Advanced Medical and Surgical Sciences, University of Campania 'Luigi Vanvitelli', Naples, Italy.
Ritelli M; Division of Biology and Genetics, Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.
Di Pietro A; Division of Neurology, Department of Advanced Medical and Surgical Sciences, University of Campania 'Luigi Vanvitelli', Naples, Italy.
Cipriano L; Division of Neurology, Department of Advanced Medical and Surgical Sciences, University of Campania 'Luigi Vanvitelli', Naples, Italy.
Colombi M; Division of Biology and Genetics, Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.
Lus G; Division of Neurology, Department of Advanced Medical and Surgical Sciences, University of Campania 'Luigi Vanvitelli', Naples, Italy.
Puoti G; Division of Neurology, Department of Advanced Medical and Surgical Sciences, University of Campania 'Luigi Vanvitelli', Naples, Italy. Electronic address: .
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Źródło :
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association [J Stroke Cerebrovasc Dis] 2021 Jun; Vol. 30 (6), pp. 105744. Date of Electronic Publication: 2021 Apr 01.
Typ publikacji :
Journal Article
MeSH Terms :
Genetic Heterogeneity*
Ischemic Stroke/*genetics
Methylenetetrahydrofolate Reductase (NADPH2)/*genetics
Multidrug Resistance-Associated Proteins/*genetics
Plasminogen Activator Inhibitor 1/*genetics
Pseudoxanthoma Elasticum/*genetics
Thrombophilia/*genetics
Adult ; Female ; Genetic Predisposition to Disease ; Heredity ; Humans ; Ischemic Stroke/blood ; Ischemic Stroke/diagnosis ; Male ; Pedigree ; Pseudoxanthoma Elasticum/complications ; Pseudoxanthoma Elasticum/diagnosis ; Risk Assessment ; Risk Factors ; Thrombophilia/blood ; Thrombophilia/complications ; Thrombophilia/diagnosis
Czasopismo naukowe
Tytuł :
Chromosomal copy number heterogeneity predicts survival rates across cancers.
Autorzy :
van Dijk E; Department of Pathology, Cancer Center Amsterdam, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
van den Bosch T; LEXOR, Center for Experimental and Molecular Medicine, Cancer Center Amsterdam and Amsterdam Gastroenterology & Metabolism, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.; Oncode Institute, Amsterdam, The Netherlands.
Lenos KJ; LEXOR, Center for Experimental and Molecular Medicine, Cancer Center Amsterdam and Amsterdam Gastroenterology & Metabolism, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.; Oncode Institute, Amsterdam, The Netherlands.
El Makrini K; LEXOR, Center for Experimental and Molecular Medicine, Cancer Center Amsterdam and Amsterdam Gastroenterology & Metabolism, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.; Oncode Institute, Amsterdam, The Netherlands.
Nijman LE; LEXOR, Center for Experimental and Molecular Medicine, Cancer Center Amsterdam and Amsterdam Gastroenterology & Metabolism, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.; Oncode Institute, Amsterdam, The Netherlands.
van Essen HFB; Department of Pathology, Cancer Center Amsterdam, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Lansu N; Oncode Institute, Amsterdam, The Netherlands.; Hubrecht institute-KNAW and University Medical Center Utrecht, Utrecht, The Netherlands.
Boekhout M; Oncode Institute, Amsterdam, The Netherlands.; Center for Molecular Medicine, University Medical Centre Utrecht, Utrecht, The Netherlands.
Hageman JH; Oncode Institute, Amsterdam, The Netherlands.; Center for Molecular Medicine, University Medical Centre Utrecht, Utrecht, The Netherlands.
Fitzgerald RC; MRC Cancer Unit, University of Cambridge, Cambridge, UK.
Punt CJA; Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.
Tuynman JB; Department of Surgery, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Snippert HJG; Oncode Institute, Amsterdam, The Netherlands.; Center for Molecular Medicine, University Medical Centre Utrecht, Utrecht, The Netherlands.
Kops GJPL; Oncode Institute, Amsterdam, The Netherlands.; Hubrecht institute-KNAW and University Medical Center Utrecht, Utrecht, The Netherlands.
Medema JP; LEXOR, Center for Experimental and Molecular Medicine, Cancer Center Amsterdam and Amsterdam Gastroenterology & Metabolism, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.; Oncode Institute, Amsterdam, The Netherlands.
Ylstra B; Department of Pathology, Cancer Center Amsterdam, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Vermeulen L; LEXOR, Center for Experimental and Molecular Medicine, Cancer Center Amsterdam and Amsterdam Gastroenterology & Metabolism, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands. .; Oncode Institute, Amsterdam, The Netherlands. .
Miedema DM; LEXOR, Center for Experimental and Molecular Medicine, Cancer Center Amsterdam and Amsterdam Gastroenterology & Metabolism, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands. .; Oncode Institute, Amsterdam, The Netherlands. .
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Źródło :
Nature communications [Nat Commun] 2021 May 27; Vol. 12 (1), pp. 3188. Date of Electronic Publication: 2021 May 27.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Copy Number Variations*
Genetic Heterogeneity*
Models, Genetic*
Neoplasms/*mortality
Tumor Microenvironment/*genetics
Adolescent ; Adult ; Aged ; Aged, 80 and over ; Child ; Computer Simulation ; Datasets as Topic ; Female ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; Genomics ; Humans ; Male ; Middle Aged ; Mutation ; Neoplasms/genetics ; Neoplasms/pathology ; Prognosis ; Progression-Free Survival ; Risk Assessment/methods ; Survival Rate ; Young Adult
Czasopismo naukowe
Tytuł :
Longitudinal single-cell profiling reveals molecular heterogeneity and tumor-immune evolution in refractory mantle cell lymphoma.
Autorzy :
Zhang S; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Jiang VC; Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Han G; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Hao D; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Lian J; Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Liu Y; Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Zhang R; Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
McIntosh J; Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Wang R; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Dang M; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Dai E; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Wang Y; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Santos D; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Badillo M; Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Leeming A; Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Chen Z; Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Hartig K; Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Bigcal J; Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Zhou J; Department of Pharmacology and Toxicology, The University of Texas Medical Branch, Galveston, TX, USA.
Kanagal-Shamanna R; Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Ok CY; Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Lee H; Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Steiner RE; Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Zhang J; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Song X; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Nair R; Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Ahmed S; Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Rodriquez A; Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Thirumurthi S; Department of Gastroenterology, Hepathology & Nutrition, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Jain P; Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Wagner-Bartak N; Department of Abdominal Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Hill H; Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Nomie K; Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Flowers C; Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Futreal A; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Wang L; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. .; MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX, USA. .
Wang M; Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. .; Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 May 17; Vol. 12 (1), pp. 2877. Date of Electronic Publication: 2021 May 17.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Genetic Heterogeneity*
Drug Resistance, Neoplasm/*genetics
Gene Expression Profiling/*methods
Lymphoma, Mantle-Cell/*genetics
Single-Cell Analysis/*methods
Tumor Microenvironment/*genetics
Animals ; Antineoplastic Agents/pharmacology ; Apoptosis/drug effects ; Apoptosis/genetics ; Cell Line, Tumor ; Cell Survival/drug effects ; Cell Survival/genetics ; Humans ; Imidazoles/pharmacology ; Lymphoma, Mantle-Cell/diagnostic imaging ; Lymphoma, Mantle-Cell/drug therapy ; Mice, Inbred NOD ; Mice, Knockout ; Mice, SCID ; Naphthoquinones/pharmacology ; Positron Emission Tomography Computed Tomography/methods ; Sequence Analysis, RNA/methods ; Xenograft Model Antitumor Assays/methods
Czasopismo naukowe
Tytuł :
Age-at-Onset and APOE -Related Heterogeneity in Pathologically Confirmed Sporadic Alzheimer Disease.
Autorzy :
Smirnov DS; From the Departments of Neurosciences (D. Smirnov, D.G., A.H., D. Salmon), Pathology (A.H.), and Family Medicine and Public Health (S. Edland), University of California San Diego.
Galasko D; From the Departments of Neurosciences (D. Smirnov, D.G., A.H., D. Salmon), Pathology (A.H.), and Family Medicine and Public Health (S. Edland), University of California San Diego.
Hiniker A; From the Departments of Neurosciences (D. Smirnov, D.G., A.H., D. Salmon), Pathology (A.H.), and Family Medicine and Public Health (S. Edland), University of California San Diego.
Edland SD; From the Departments of Neurosciences (D. Smirnov, D.G., A.H., D. Salmon), Pathology (A.H.), and Family Medicine and Public Health (S. Edland), University of California San Diego.
Salmon DP; From the Departments of Neurosciences (D. Smirnov, D.G., A.H., D. Salmon), Pathology (A.H.), and Family Medicine and Public Health (S. Edland), University of California San Diego. .
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Źródło :
Neurology [Neurology] 2021 May 04; Vol. 96 (18), pp. e2272-e2283. Date of Electronic Publication: 2021 Mar 15.
Typ publikacji :
Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Genetic Heterogeneity*
Alzheimer Disease/*genetics
Alzheimer Disease/*pathology
Apolipoproteins E/*genetics
Age of Onset ; Aged ; Aged, 80 and over ; Alzheimer Disease/epidemiology ; Female ; Humans ; Male ; Middle Aged ; Retrospective Studies
Czasopismo naukowe
Tytuł :
Genetic Alterations and Therapeutic Targeting of Philadelphia-Like Acute Lymphoblastic Leukemia.
Autorzy :
Iacobucci I; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Roberts KG; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
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Źródło :
Genes [Genes (Basel)] 2021 May 01; Vol. 12 (5). Date of Electronic Publication: 2021 May 01.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Genetic Heterogeneity*
Precursor Cell Lymphoblastic Leukemia-Lymphoma/*genetics
Humans ; Immunotherapy/methods ; Janus Kinases/genetics ; Janus Kinases/metabolism ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/therapy ; Protein Kinase Inhibitors/therapeutic use ; Proto-Oncogene Proteins c-abl/genetics ; Proto-Oncogene Proteins c-abl/metabolism
Czasopismo naukowe
Tytuł :
Heterogeneity of fetal hemoglobin production in adult red blood cells.
Autorzy :
Khandros E; Division of Hematology, The Children's Hospital of Philadelphia; Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Blobel GA
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Źródło :
Current opinion in hematology [Curr Opin Hematol] 2021 May 01; Vol. 28 (3), pp. 164-170.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Gene Expression Regulation*/drug effects
Genetic Heterogeneity*
Erythrocytes/*metabolism
Fetal Hemoglobin/*biosynthesis
Fetal Hemoglobin/*genetics
Adult ; Age Factors ; Anemia, Sickle Cell/blood ; Anemia, Sickle Cell/diagnosis ; Anemia, Sickle Cell/drug therapy ; Anemia, Sickle Cell/genetics ; Animals ; Disease Management ; Disease Susceptibility ; Erythrocytes/drug effects ; Humans ; beta-Thalassemia/blood ; beta-Thalassemia/diagnosis ; beta-Thalassemia/genetics ; beta-Thalassemia/therapy
Czasopismo naukowe

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