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Tytuł:
Modeling and Analysis of HIV-1 Pol Polyprotein as a Case Study for Predicting Large Polyprotein Structures.
Autorzy:
Hao M; Laboratory of Human Retrovirology and Immunoinformatics, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.
Imamichi T; Laboratory of Human Retrovirology and Immunoinformatics, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.
Chang W; Laboratory of Human Retrovirology and Immunoinformatics, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Feb 02; Vol. 25 (3). Date of Electronic Publication: 2024 Feb 02.
Typ publikacji:
Journal Article
MeSH Terms:
HIV Infections*/drug therapy
HIV-1*/genetics
HIV-1*/metabolism
pol Gene Products, Human Immunodeficiency Virus*/chemistry
Humans ; Gene Products, pol/genetics ; Gene Products, pol/metabolism ; HIV Protease/genetics ; HIV Protease/metabolism ; Polyproteins/genetics ; RNA-Directed DNA Polymerase/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
HIV-1 Tat Induces Dysregulation of PGC1-Alpha and Sirtuin 3 Expression in Neurons: The Role of Mitochondrial Biogenesis in HIV-Associated Neurocognitive Disorder (HAND).
Autorzy:
Figarola-Centurión I; Doctorado en Genética Humana, Departamento de Biología Molecular y Genómica, Universidad de Guadalajara, Guadalajara 44340, Mexico.; Laboratorio de Inmunodeficiencias y Retrovirus Humanos, Centro de Investigación Biomédica de Occidente, Instituto Mexicano del Seguro Social, Guadalajara 44340, Mexico.
Escoto-Delgadillo M; Laboratorio de Inmunodeficiencias y Retrovirus Humanos, Centro de Investigación Biomédica de Occidente, Instituto Mexicano del Seguro Social, Guadalajara 44340, Mexico.; Centro Universitario de Ciencias Biológicas y Agropecuarias, Universidad de Guadalajara, Guadalajara 44600, Mexico.
González-Enríquez GV; Departamento de Disciplinas Filosófico, Metodológicas e Instrumentales, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, Mexico.
Gutiérrez-Sevilla JE; Laboratorio de Inmunodeficiencias y Retrovirus Humanos, Centro de Investigación Biomédica de Occidente, Instituto Mexicano del Seguro Social, Guadalajara 44340, Mexico.; Doctorado en Microbiología Médica, Departamento de Microbiología y Patología, Universidad de Guadalajara, Guadalajara 44340, Mexico.
Vázquez-Valls E; Investigación y Calidad de Salud, Secretaría de Salud, Guadalajara 44100, Mexico.
Cárdenas-Bedoya J; Laboratorio de Inmunodeficiencias y Retrovirus Humanos, Centro de Investigación Biomédica de Occidente, Instituto Mexicano del Seguro Social, Guadalajara 44340, Mexico.; Departamento de Disciplinas Filosófico, Metodológicas e Instrumentales, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, Mexico.
Torres-Mendoza BM; Laboratorio de Inmunodeficiencias y Retrovirus Humanos, Centro de Investigación Biomédica de Occidente, Instituto Mexicano del Seguro Social, Guadalajara 44340, Mexico.; Departamento de Disciplinas Filosófico, Metodológicas e Instrumentales, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, Mexico.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Dec 17; Vol. 24 (24). Date of Electronic Publication: 2023 Dec 17.
Typ publikacji:
Journal Article
MeSH Terms:
HIV Infections*/metabolism
HIV-1*/metabolism
Neurocognitive Disorders*/metabolism
Neurocognitive Disorders*/virology
Sirtuin 3*/genetics
Sirtuin 3*/metabolism
tat Gene Products, Human Immunodeficiency Virus*/genetics
tat Gene Products, Human Immunodeficiency Virus*/metabolism
Animals ; Rats ; Gene Products, tat/metabolism ; Neurons/metabolism ; Organelle Biogenesis ; Protein Kinases/metabolism ; Rats, Sprague-Dawley ; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
TAT peptide at treatment-level concentrations crossed brain endothelial cell monolayer independent of receptor-mediated endocytosis or peptide-inflicted barrier disruption.
Autorzy:
Wu MC; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan.; School of Chinese Medicine, China Medical University, Taichung, Taiwan.
Wang EY; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan.; School of Medicine, China Medical University, Taichung, Taiwan.
Lai TW; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan.; School of Medicine, China Medical University, Taichung, Taiwan.; Neuroscience and Brain Disease Center, China Medical University, Taichung, Taiwan.; Drug Development Center, China Medical University, Taichung, Taiwan.; Translational Medicine Research Center, China Medical University Hospital, Taichung, Taiwan.
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Źródło:
PloS one [PLoS One] 2023 Oct 11; Vol. 18 (10), pp. e0292681. Date of Electronic Publication: 2023 Oct 11 (Print Publication: 2023).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Endothelial Cells*/metabolism
tat Gene Products, Human Immunodeficiency Virus*/metabolism
Brain/metabolism ; Blood-Brain Barrier/metabolism ; Peptides/metabolism ; Endocytosis
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
HIV-1 Transcriptional Activator Tat Inhibits IL2 Expression by Preventing the Presence of Pol II on the IL2 Promoter.
Autorzy:
Anastasopoulou S; Laboratory of Immunohematology, Division of Hematology, Department of Internal Medicine, Medical School, University of Patras, GR-26500 Patras, Greece.
Georgakopoulos T; Laboratory of Immunohematology, Division of Hematology, Department of Internal Medicine, Medical School, University of Patras, GR-26500 Patras, Greece.
Mouzaki A; Laboratory of Immunohematology, Division of Hematology, Department of Internal Medicine, Medical School, University of Patras, GR-26500 Patras, Greece.
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Źródło:
Biomolecules [Biomolecules] 2023 May 24; Vol. 13 (6). Date of Electronic Publication: 2023 May 24.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
HIV Infections*/genetics
HIV Infections*/immunology
HIV Infections*/virology
HIV-1*/genetics
HIV-1*/metabolism
Interleukin-2*/genetics
Interleukin-2*/metabolism
RNA Polymerase II*/genetics
RNA Polymerase II*/metabolism
tat Gene Products, Human Immunodeficiency Virus*/genetics
tat Gene Products, Human Immunodeficiency Virus*/metabolism
Humans ; Gene Expression Regulation, Viral ; Transcription Factors/metabolism ; Transcription, Genetic ; Transcriptional Activation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
A Novel Time-Resolved Fluorescence Resonance Energy Transfer Assay for the Discovery of Small-Molecule Inhibitors of HIV-1 Tat-Regulated Transcription.
Autorzy:
Shin YH; Division of Chronic Viral Diseases, Center for Emerging Virus Research, Korea National Institute of Health, 187 Osongsaengmyeong 2-ro, Cheongju 363951, Republic of Korea.
Kim DE; Division of Chronic Viral Diseases, Center for Emerging Virus Research, Korea National Institute of Health, 187 Osongsaengmyeong 2-ro, Cheongju 363951, Republic of Korea.
Yu KL; Division of Chronic Viral Diseases, Center for Emerging Virus Research, Korea National Institute of Health, 187 Osongsaengmyeong 2-ro, Cheongju 363951, Republic of Korea.
Park CM; Department for Convergent Research of Emerging Virus Infection, Korea Research Institute of Chemical Technology, 141 Gajeong-ro, Daejeon 34114, Republic of Korea.
Kim HG; Department for Convergent Research of Emerging Virus Infection, Korea Research Institute of Chemical Technology, 141 Gajeong-ro, Daejeon 34114, Republic of Korea.
Kim KC; Division of Chronic Viral Diseases, Center for Emerging Virus Research, Korea National Institute of Health, 187 Osongsaengmyeong 2-ro, Cheongju 363951, Republic of Korea.
Bae S; Division of Chronic Viral Diseases, Center for Emerging Virus Research, Korea National Institute of Health, 187 Osongsaengmyeong 2-ro, Cheongju 363951, Republic of Korea.
Yoon CH; Division of Chronic Viral Diseases, Center for Emerging Virus Research, Korea National Institute of Health, 187 Osongsaengmyeong 2-ro, Cheongju 363951, Republic of Korea.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 May 23; Vol. 24 (11). Date of Electronic Publication: 2023 May 23.
Typ publikacji:
Journal Article
MeSH Terms:
tat Gene Products, Human Immunodeficiency Virus*/genetics
tat Gene Products, Human Immunodeficiency Virus*/chemistry
HIV-1*/physiology
Humans ; Fluorescence Resonance Energy Transfer ; Trans-Activators ; RNA, Viral/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Bioinformatics Insights on Viral Gene Expression Transactivation: From HIV-1 to SARS-CoV-2.
Autorzy:
Patarca R; ACCESS Health International, 384 West Lane, Ridgefield, CT 06877, USA.; Feinstein Institutes for Medical Research, 350 Community Dr, Manhasset, NY 11030, USA.
Haseltine WA; ACCESS Health International, 384 West Lane, Ridgefield, CT 06877, USA.; Feinstein Institutes for Medical Research, 350 Community Dr, Manhasset, NY 11030, USA.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Mar 16; Vol. 25 (6). Date of Electronic Publication: 2024 Mar 16.
Typ publikacji:
Journal Article
MeSH Terms:
HIV-1*/physiology
COVID-19*/genetics
Humans ; SARS-CoV-2/genetics ; SARS-CoV-2/metabolism ; Transcriptional Activation ; HIV Long Terminal Repeat ; Gene Products, tat/genetics ; Lentivirus/genetics ; Gene Expression ; tat Gene Products, Human Immunodeficiency Virus/genetics ; tat Gene Products, Human Immunodeficiency Virus/metabolism ; RNA, Viral/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
HIV-1 Vpr Functions in Primary CD4 T Cells.
Autorzy:
Vanegas-Torres CA; Institute for Medical Virology and Epidemiology of Viral Diseases, University Hospital Tuebingen, 72076 Tuebingen, Germany.
Schindler M; Institute for Medical Virology and Epidemiology of Viral Diseases, University Hospital Tuebingen, 72076 Tuebingen, Germany.
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Źródło:
Viruses [Viruses] 2024 Mar 09; Vol. 16 (3). Date of Electronic Publication: 2024 Mar 09.
Typ publikacji:
Journal Article; Review
MeSH Terms:
HIV-1*/genetics
HIV Seropositivity*
HIV Infections*/metabolism
Humans ; T-Lymphocytes/metabolism ; vpr Gene Products, Human Immunodeficiency Virus/genetics ; vpr Gene Products, Human Immunodeficiency Virus/metabolism ; CD4-Positive T-Lymphocytes/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Maturation of the matrix and viral membrane of HIV-1.
Autorzy:
Qu K; Molecular Medicine Partnership Unit, European Molecular Biology Laboratory and Universitätsklinikum Heidelberg, 69117 Heidelberg, Germany.; Structural Studies Division, Medical Research Council Laboratory of Molecular Biology, CB2 0QH Cambridge, UK.; Structural and Computational Biology Unit, European Molecular Biology Laboratory, 69117 Heidelberg, Germany.; Molecular Medicine Partnership Unit, European Molecular Biology Laboratory and Universitätsklinikum Heidelberg, 69117 Heidelberg, Germany.
Ke Z; Department of Infectious Diseases, Virology, Universitätsklinikum Heidelberg, 69120 Heidelberg, Germany.; Structural Studies Division, Medical Research Council Laboratory of Molecular Biology, CB2 0QH Cambridge, UK.
Zila V; Structural Studies Division, Medical Research Council Laboratory of Molecular Biology, CB2 0QH Cambridge, UK.; Department of Infectious Diseases, Virology, Universitätsklinikum Heidelberg, 69120 Heidelberg, Germany.
Anders-Össwein M; Department of Infectious Diseases, Virology, Universitätsklinikum Heidelberg, 69120 Heidelberg, Germany.
Glass B; Structural and Computational Biology Unit, European Molecular Biology Laboratory, 69117 Heidelberg, Germany.; Department of Infectious Diseases, Virology, Universitätsklinikum Heidelberg, 69120 Heidelberg, Germany.
Mücksch F; Department of Infectious Diseases, Virology, Universitätsklinikum Heidelberg, 69120 Heidelberg, Germany.
Müller R; Molecular Medicine Partnership Unit, European Molecular Biology Laboratory and Universitätsklinikum Heidelberg, 69117 Heidelberg, Germany.; Cell Biology and Biophysics Unit, European Molecular Biology Laboratory, 69117 Heidelberg, Germany.
Schultz C; Molecular Medicine Partnership Unit, European Molecular Biology Laboratory and Universitätsklinikum Heidelberg, 69117 Heidelberg, Germany.; Cell Biology and Biophysics Unit, European Molecular Biology Laboratory, 69117 Heidelberg, Germany.; Department of Chemical Physiology and Biochemistry, Oregon Health & Science University, Portland, OR 97239, USA.
Müller B; Structural Studies Division, Medical Research Council Laboratory of Molecular Biology, CB2 0QH Cambridge, UK.; Structural and Computational Biology Unit, European Molecular Biology Laboratory, 69117 Heidelberg, Germany.; Department of Infectious Diseases, Virology, Universitätsklinikum Heidelberg, 69120 Heidelberg, Germany.
Kräusslich HG; Department of Infectious Diseases, Virology, Universitätsklinikum Heidelberg, 69120 Heidelberg, Germany.; Cell Biology and Biophysics Unit, European Molecular Biology Laboratory, 69117 Heidelberg, Germany.; Structural Studies Division, Medical Research Council Laboratory of Molecular Biology, CB2 0QH Cambridge, UK.; Molecular Medicine Partnership Unit, European Molecular Biology Laboratory and Universitätsklinikum Heidelberg, 69117 Heidelberg, Germany.; Department of Infectious Diseases, Virology, Universitätsklinikum Heidelberg, 69120 Heidelberg, Germany.; German Center for Infection Research, Heidelberg, Germany.
Briggs JAG; Department of Infectious Diseases, Virology, Universitätsklinikum Heidelberg, 69120 Heidelberg, Germany. .; Molecular Medicine Partnership Unit, European Molecular Biology Laboratory and Universitätsklinikum Heidelberg, 69117 Heidelberg, Germany.; Structural Studies Division, Medical Research Council Laboratory of Molecular Biology, CB2 0QH Cambridge, UK.; Structural and Computational Biology Unit, European Molecular Biology Laboratory, 69117 Heidelberg, Germany.; Molecular Medicine Partnership Unit, European Molecular Biology Laboratory and Universitätsklinikum Heidelberg, 69117 Heidelberg, Germany.
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Źródło:
Science (New York, N.Y.) [Science] 2021 Aug 06; Vol. 373 (6555), pp. 700-704.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
HIV Antigens/*chemistry
HIV Antigens/*metabolism
HIV-1/*chemistry
HIV-1/*physiology
Viral Envelope/*metabolism
gag Gene Products, Human Immunodeficiency Virus/*chemistry
gag Gene Products, Human Immunodeficiency Virus/*metabolism
Capsid/chemistry ; Capsid/physiology ; Electron Microscope Tomography ; HIV-1/ultrastructure ; Lipid Bilayers ; Membrane Lipids/metabolism ; Models, Molecular ; Protein Conformation ; Protein Domains ; Protein Structure, Secondary ; Viral Envelope/chemistry ; Viral Envelope/ultrastructure ; Virion/chemistry ; Virion/physiology ; Virion/ultrastructure ; Virus Assembly ; env Gene Products, Human Immunodeficiency Virus/chemistry ; env Gene Products, Human Immunodeficiency Virus/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Beyond Impairment of Virion Infectivity: New Activities of the Anti-HIV Host Cell Factor SERINC5.
Autorzy:
Sid Ahmed S; Department of Infectious Diseases, Integrative Virology, University Hospital Heidelberg, Im Neuenheimer Feld 344, 69120 Heidelberg, Germany.
Bajak K; Department of Infectious Diseases, Integrative Virology, University Hospital Heidelberg, Im Neuenheimer Feld 344, 69120 Heidelberg, Germany.; German Centre for Infection Research (DZIF), Partner Site Heidelberg, 38124 Heidelberg, Germany.
Fackler OT; Department of Infectious Diseases, Integrative Virology, University Hospital Heidelberg, Im Neuenheimer Feld 344, 69120 Heidelberg, Germany.; German Centre for Infection Research (DZIF), Partner Site Heidelberg, 38124 Heidelberg, Germany.
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Źródło:
Viruses [Viruses] 2024 Feb 12; Vol. 16 (2). Date of Electronic Publication: 2024 Feb 12.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Membrane Proteins*/metabolism
HIV Infections*
Humans ; nef Gene Products, Human Immunodeficiency Virus/metabolism ; Host-Pathogen Interactions ; Virion/metabolism ; Antiviral Agents
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
A Conserved Acidic Residue in the C-Terminal Flexible Loop of HIV-1 Nef Contributes to the Activity of SERINC5 and CD4 Downregulation.
Autorzy:
Firrito C; Department of Cellular, Computational and integrative Biology, University of Trento, 38123 Trento, Italy.
Bertelli C; Department of Cellular, Computational and integrative Biology, University of Trento, 38123 Trento, Italy.
Rosa A; Department of Cellular, Computational and integrative Biology, University of Trento, 38123 Trento, Italy.
Chande A; Department of Cellular, Computational and integrative Biology, University of Trento, 38123 Trento, Italy.
Ananth S; Department of Infectious Diseases, Integrative Virology, University Hospital Heidelberg, 69120 Heidelberg, Germany.
van Dijk H; Department of Infectious Diseases, Integrative Virology, University Hospital Heidelberg, 69120 Heidelberg, Germany.
Fackler OT; Department of Infectious Diseases, Integrative Virology, University Hospital Heidelberg, 69120 Heidelberg, Germany.; German Center for Infection Research (DZIF), 69120 Heidelberg, Germany.
Stoneham C; Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA.; VA San Diego Healthcare System, San Diego, CA 92161, USA.
Singh R; Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA.; VA San Diego Healthcare System, San Diego, CA 92161, USA.
Guatelli J; Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA.; VA San Diego Healthcare System, San Diego, CA 92161, USA.
Pizzato M; Department of Cellular, Computational and integrative Biology, University of Trento, 38123 Trento, Italy.
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Źródło:
Viruses [Viruses] 2023 Feb 28; Vol. 15 (3). Date of Electronic Publication: 2023 Feb 28.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
CD4-Positive T-Lymphocytes*/immunology
CD4-Positive T-Lymphocytes*/virology
Membrane Proteins*/metabolism
nef Gene Products, Human Immunodeficiency Virus*/chemistry
HIV-1*/pathogenicity
CD4 Antigens*/metabolism
Humans ; Amino Acid Substitution ; HEK293 Cells ; Jurkat Cells ; Amino Acid Sequence ; Endocytosis ; Clathrin ; HIV Infections ; Down-Regulation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Depressive-like Behavior Is Accompanied by Prefrontal Cortical Innate Immune Fatigue and Dendritic Spine Losses after HIV-1 Tat and Morphine Exposure.
Autorzy:
Nass SR; Department of Pharmacology and Toxicology, Medical College of Virginia (MCV) Campus, Virginia Commonwealth University, Richmond, VA 23298-0613, USA.
Hahn YK; Department of Anatomy and Neurobiology, Medical College of Virginia (MCV) Campus, Virginia Commonwealth University, Richmond, VA 23298-0709, USA.
Ohene-Nyako M; Department of Pharmacology and Toxicology, Medical College of Virginia (MCV) Campus, Virginia Commonwealth University, Richmond, VA 23298-0613, USA.
McLane VD; Department of Pharmacology and Toxicology, Medical College of Virginia (MCV) Campus, Virginia Commonwealth University, Richmond, VA 23298-0613, USA.
Damaj MI; Department of Pharmacology and Toxicology, Medical College of Virginia (MCV) Campus, Virginia Commonwealth University, Richmond, VA 23298-0613, USA.
Thacker LR 2nd; Department of Biostatistics, Medical College of Virginia (MCV) Campus, Virginia Commonwealth University, Richmond, VA 23219, USA.
Knapp PE; Department of Pharmacology and Toxicology, Medical College of Virginia (MCV) Campus, Virginia Commonwealth University, Richmond, VA 23298-0613, USA.; Department of Anatomy and Neurobiology, Medical College of Virginia (MCV) Campus, Virginia Commonwealth University, Richmond, VA 23298-0709, USA.; Institute for Drug and Alcohol Studies, Medical College of Virginia (MCV) Campus, Virginia Commonwealth University, Richmond, VA 23298-0059, USA.
Hauser KF; Department of Pharmacology and Toxicology, Medical College of Virginia (MCV) Campus, Virginia Commonwealth University, Richmond, VA 23298-0613, USA.; Department of Anatomy and Neurobiology, Medical College of Virginia (MCV) Campus, Virginia Commonwealth University, Richmond, VA 23298-0709, USA.; Institute for Drug and Alcohol Studies, Medical College of Virginia (MCV) Campus, Virginia Commonwealth University, Richmond, VA 23298-0059, USA.
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Źródło:
Viruses [Viruses] 2023 Feb 21; Vol. 15 (3). Date of Electronic Publication: 2023 Feb 21.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Depression*/chemically induced
Depression*/immunology
Prefrontal Cortex*/immunology
Immunity, Innate*
Dendritic Spines*/pathology
tat Gene Products, Human Immunodeficiency Virus*/adverse effects
Morphine*/adverse effects
Male ; Animals ; Mice ; Behavior, Animal ; Cytokines/immunology ; Interleukin-10/immunology ; Neuroinflammatory Diseases ; Mice, Transgenic ; Opioid-Related Disorders ; HIV Infections ; Analgesics, Opioid/adverse effects
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
HIV-1 release requires Nef-induced caspase activation.
Autorzy:
Segura J; Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, United States of America.
Ireland J; Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, United States of America.
Zou Z; Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, United States of America.
Roth G; Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, United States of America.
Buchwald J; Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, United States of America.
Shen TJ; Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, United States of America.
Fischer E; Research Technology Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America.
Moir S; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America.
Chun TW; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America.
Sun PD; Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, United States of America.
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Źródło:
PloS one [PLoS One] 2023 Feb 13; Vol. 18 (2), pp. e0281087. Date of Electronic Publication: 2023 Feb 13 (Print Publication: 2023).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural
MeSH Terms:
HIV Infections*/drug therapy
HIV Seropositivity*
HIV-1*/genetics
nef Gene Products, Human Immunodeficiency Virus*/metabolism
Humans ; Caspases/metabolism ; CD4-Positive T-Lymphocytes/metabolism ; Cell Death
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Involvement of a Rarely Used Splicing SD2b Site in the Regulation of HIV-1 vif mRNA Production as Revealed by a Growth-Adaptive Mutation.
Autorzy:
Koma T; Department of Microbiology, Graduate School of Medicine, Tokushima University, Tokushima 770-8503, Japan.
Doi N; Department of Microbiology, Graduate School of Medicine, Tokushima University, Tokushima 770-8503, Japan.
Le BQ; Department of Microbiology, Graduate School of Medicine, Tokushima University, Tokushima 770-8503, Japan.
Kondo T; Department of Microbiology, Graduate School of Medicine, Tokushima University, Tokushima 770-8503, Japan.
Ishizue M; Department of Microbiology, Graduate School of Medicine, Tokushima University, Tokushima 770-8503, Japan.; Faculty of Medicine, Tokushima University, Tokushima 770-8503, Japan.
Tokaji C; Department of Microbiology, Graduate School of Medicine, Tokushima University, Tokushima 770-8503, Japan.; Faculty of Medicine, Tokushima University, Tokushima 770-8503, Japan.
Tsukada C; Department of Microbiology, Graduate School of Medicine, Tokushima University, Tokushima 770-8503, Japan.; Faculty of Medicine, Tokushima University, Tokushima 770-8503, Japan.
Adachi A; Department of Microbiology, Graduate School of Medicine, Tokushima University, Tokushima 770-8503, Japan.
Nomaguchi M; Department of Microbiology, Graduate School of Medicine, Tokushima University, Tokushima 770-8503, Japan.
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Źródło:
Viruses [Viruses] 2023 Dec 14; Vol. 15 (12). Date of Electronic Publication: 2023 Dec 14.
Typ publikacji:
Journal Article
MeSH Terms:
HIV-1*/physiology
RNA, Messenger/genetics ; Cell Line ; vif Gene Products, Human Immunodeficiency Virus/genetics ; vif Gene Products, Human Immunodeficiency Virus/metabolism ; Virus Replication/genetics ; Cytidine Deaminase/genetics ; Mutation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Super-Resolution STED Microscopy-Based Mobility Studies of the Viral Env Protein at HIV-1 Assembly Sites of Fully Infected T-Cells.
Autorzy:
Chojnacki J; MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.; IrsiCaixa AIDS Research Institute, University Hospital Germans Trias i Pujol, Ctra. de Canyet s/n, Badalona, 08916 Barcelona, Spain.
Eggeling C; MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.; Institute of Applied Optics and Biophysics, Friedrich-Schiller-University Jena, Max-Wien Platz 4, 07743 Jena, Germany.; Leibniz Institute of Photonic Technology e.V., Albert-Einstein-Straße 9, 07745 Jena, Germany.
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Źródło:
Viruses [Viruses] 2021 Apr 02; Vol. 13 (4). Date of Electronic Publication: 2021 Apr 02.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Virus Assembly*
HIV-1/*physiology
Microscopy/*methods
Microscopy, Fluorescence/*methods
env Gene Products, Human Immunodeficiency Virus/*chemistry
HEK293 Cells ; HIV-1/ultrastructure ; Humans ; Jurkat Cells ; Microscopy/instrumentation ; Molecular Dynamics Simulation ; env Gene Products, Human Immunodeficiency Virus/metabolism ; env Gene Products, Human Immunodeficiency Virus/ultrastructure ; gag Gene Products, Human Immunodeficiency Virus/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
The Persistence of HIV Diversity, Transcription, and Nef Protein in Kaposi's Sarcoma Tumors during Antiretroviral Therapy.
Autorzy:
Nolan DJ; Bioinfoexperts, LLC, Thibodaux, LA 70301, USA.
Rose R; Bioinfoexperts, LLC, Thibodaux, LA 70301, USA.
Zhang R; Departments of Laboratory Medicine, Pathology and Medicine, The University of California at San Francisco, San Francisco, CA 94110, USA.
Leong A; Departments of Laboratory Medicine, Pathology and Medicine, The University of California at San Francisco, San Francisco, CA 94110, USA.
Fogel GB; Natural Selection, Inc., San Diego, CA 92127, USA.
Scholte LLS; Department of Microbiology, Immunology and Tropical Medicine, The George Washington University, Washington, DC 20037, USA.
Bethony JM; Department of Microbiology, Immunology and Tropical Medicine, The George Washington University, Washington, DC 20037, USA.
Bracci P; The AIDS and Cancer Specimen Resource, San Francisco, CA 94110, USA.
Lamers SL; Bioinfoexperts, LLC, Thibodaux, LA 70301, USA.
McGrath MS; Departments of Laboratory Medicine, Pathology and Medicine, The University of California at San Francisco, San Francisco, CA 94110, USA.
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Źródło:
Viruses [Viruses] 2022 Dec 13; Vol. 14 (12). Date of Electronic Publication: 2022 Dec 13.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Herpesvirus 8, Human*/genetics
HIV Infections*/complications
HIV Infections*/drug therapy
nef Gene Products, Human Immunodeficiency Virus*/genetics
Sarcoma, Kaposi*
Humans ; Gene Products, nef ; HIV/genetics ; Leukocytes, Mononuclear/pathology ; RNA ; Tumor Microenvironment
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The HIV-1 Integrase C-Terminal Domain Induces TAR RNA Structural Changes Promoting Tat Binding.
Autorzy:
Rocchi C; Molecular Microbiology and Structural Biochemistry, MMSB-IBCP, UMR 5086, CNRS, University of Lyon, 7 Passage du Vercors, CEDEX 07, 69367 Lyon, France.
Louvat C; Molecular Microbiology and Structural Biochemistry, MMSB-IBCP, UMR 5086, CNRS, University of Lyon, 7 Passage du Vercors, CEDEX 07, 69367 Lyon, France.
Miele AE; Institute of Analytical Sciences, UMR 5280 CNRS UCBL University of Lyon, 5 Rue de la Doua, 69100 Villeurbanne, France.; Department of Biochemical Sciences, Sapienza University of Rome, P.le Aldo Moro 5, 00185 Rome, Italy.
Batisse J; Chromatin Stability and DNA Mobility, Department of Integrated Structural Biology, IGBMC, CNRS, UMR 7104-Inserm U 158, University of Strasbourg, 1 rue Laurent Fries, 67404 Illkirch, France.
Guillon C; Molecular Microbiology and Structural Biochemistry, MMSB-IBCP, UMR 5086, CNRS, University of Lyon, 7 Passage du Vercors, CEDEX 07, 69367 Lyon, France.
Ballut L; Molecular Microbiology and Structural Biochemistry, MMSB-IBCP, UMR 5086, CNRS, University of Lyon, 7 Passage du Vercors, CEDEX 07, 69367 Lyon, France.
Lener D; RNA Architecture and Reactivity, IBMC, CNRS, UPR 9002, University of Strasbourg, 2, Allée Konrad Roentgen, 67084 Strasbourg, France.
Negroni M; RNA Architecture and Reactivity, IBMC, CNRS, UPR 9002, University of Strasbourg, 2, Allée Konrad Roentgen, 67084 Strasbourg, France.
Ruff M; Chromatin Stability and DNA Mobility, Department of Integrated Structural Biology, IGBMC, CNRS, UMR 7104-Inserm U 158, University of Strasbourg, 1 rue Laurent Fries, 67404 Illkirch, France.
Gouet P; Molecular Microbiology and Structural Biochemistry, MMSB-IBCP, UMR 5086, CNRS, University of Lyon, 7 Passage du Vercors, CEDEX 07, 69367 Lyon, France.
Fiorini F; Molecular Microbiology and Structural Biochemistry, MMSB-IBCP, UMR 5086, CNRS, University of Lyon, 7 Passage du Vercors, CEDEX 07, 69367 Lyon, France.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Nov 08; Vol. 23 (22). Date of Electronic Publication: 2022 Nov 08.
Typ publikacji:
Journal Article
MeSH Terms:
tat Gene Products, Human Immunodeficiency Virus*/genetics
HIV Integrase*/genetics
RNA, Viral/genetics ; RNA, Viral/metabolism ; Transcription Factors
Czasopismo naukowe
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Tytuł:
The NeuroinflammatoryPotential of HIV-1 NefVariants in Modulating the Gene Expression Profile of Astrocytes.
Autorzy:
Jadhav S; Indian Council of Medical Research, Department of Molecular Biology, National AIDS Research Institute, 73, G Block, MIDC, Bhosari, P.O. Box No. 1895, Pune 411026, Maharashtra, India.; Faculty of Health Sciences, Symbiosis International (Deemed University), Lavale, Mulshi, Pune 412115, Maharashtra, India.
Makar P; Institute of Bioinformatics and Biotechnology (IBB), S. Phule Pune University, Pune 411007, Maharashtra, India.
Nema V; Indian Council of Medical Research, Department of Molecular Biology, National AIDS Research Institute, 73, G Block, MIDC, Bhosari, P.O. Box No. 1895, Pune 411026, Maharashtra, India.
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Źródło:
Cells [Cells] 2022 Oct 17; Vol. 11 (20). Date of Electronic Publication: 2022 Oct 17.
Typ publikacji:
Journal Article
MeSH Terms:
Astrocytes*/metabolism
Astrocytes*/virology
HIV Infections*/genetics
HIV Infections*/virology
HIV-1*/metabolism
Neuroinflammatory Diseases*/genetics
Neuroinflammatory Diseases*/virology
nef Gene Products, Human Immunodeficiency Virus*/genetics
nef Gene Products, Human Immunodeficiency Virus*/metabolism
Humans ; 3-Hydroxyanthranilate 3,4-Dioxygenase/genetics ; 3-Hydroxyanthranilate 3,4-Dioxygenase/metabolism ; Chemokine CXCL10/metabolism ; Cytokines/metabolism ; Indoleamine-Pyrrole 2,3,-Dioxygenase/metabolism ; Interleukin-6/metabolism ; Kynurenine/metabolism ; Nitric Oxide/metabolism ; RNA, Small Interfering/metabolism ; Transcriptome ; Tumor Necrosis Factor-alpha/metabolism ; Gene Expression Profiling
Czasopismo naukowe
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Tytuł:
Role of HIV-1 Tat Protein Interactions with Host Receptors in HIV Infection and Pathogenesis.
Autorzy:
Cafaro A; National HIV/AIDS Research Center, Istituto Superiore di Sanità, 00161 Rome, Italy.
Schietroma I; National HIV/AIDS Research Center, Istituto Superiore di Sanità, 00161 Rome, Italy.
Sernicola L; National HIV/AIDS Research Center, Istituto Superiore di Sanità, 00161 Rome, Italy.
Belli R; National HIV/AIDS Research Center, Istituto Superiore di Sanità, 00161 Rome, Italy.
Campagna M; National HIV/AIDS Research Center, Istituto Superiore di Sanità, 00161 Rome, Italy.
Mancini F; National HIV/AIDS Research Center, Istituto Superiore di Sanità, 00161 Rome, Italy.
Farcomeni S; National HIV/AIDS Research Center, Istituto Superiore di Sanità, 00161 Rome, Italy.
Pavone-Cossut MR; National HIV/AIDS Research Center, Istituto Superiore di Sanità, 00161 Rome, Italy.
Borsetti A; National HIV/AIDS Research Center, Istituto Superiore di Sanità, 00161 Rome, Italy.
Monini P; National HIV/AIDS Research Center, Istituto Superiore di Sanità, 00161 Rome, Italy.
Ensoli B; National HIV/AIDS Research Center, Istituto Superiore di Sanità, 00161 Rome, Italy.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Jan 30; Vol. 25 (3). Date of Electronic Publication: 2024 Jan 30.
Typ publikacji:
Journal Article; Review
MeSH Terms:
HIV Infections*
HIV-1*/metabolism
Vaccines*/therapeutic use
Humans ; tat Gene Products, Human Immunodeficiency Virus/metabolism ; Antibodies, Neutralizing
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Identification of viral protein R of human immunodeficiency virus-1 (HIV) and interleukin-6 as risk factors for malignancies in HIV-infected individuals: A cohort study.
Autorzy:
Matsunaga A; Department of Intractable Diseases, Research Institute, National Center for Global Health and Medicine, Toyama, Shinjuku, Tokyo, Japan.
Ando N; AIDS Clinical Center, Hospital, National Center for Global Health and Medicine, Toyama, Shinjuku, Tokyo, Japan.
Yamagata Y; Department of Intractable Diseases, Research Institute, National Center for Global Health and Medicine, Toyama, Shinjuku, Tokyo, Japan.; RIKEN SPring-8 Center, Koto, Sayo, Hyogo, Japan.
Shimura M; Department of Intractable Diseases, Research Institute, National Center for Global Health and Medicine, Toyama, Shinjuku, Tokyo, Japan.; RIKEN SPring-8 Center, Koto, Sayo, Hyogo, Japan.
Gatanaga H; AIDS Clinical Center, Hospital, National Center for Global Health and Medicine, Toyama, Shinjuku, Tokyo, Japan.
Oka S; AIDS Clinical Center, Hospital, National Center for Global Health and Medicine, Toyama, Shinjuku, Tokyo, Japan.
Ishizaka Y; Department of Intractable Diseases, Research Institute, National Center for Global Health and Medicine, Toyama, Shinjuku, Tokyo, Japan.
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Źródło:
PloS one [PLoS One] 2024 Jan 02; Vol. 19 (1), pp. e0296502. Date of Electronic Publication: 2024 Jan 02 (Print Publication: 2024).
Typ publikacji:
Journal Article
MeSH Terms:
HIV-1*
HIV Infections*/complications
HIV Infections*/drug therapy
HIV Infections*/metabolism
Neoplasms*
Humans ; Interleukin-6 ; vpr Gene Products, Human Immunodeficiency Virus ; Cohort Studies ; Risk Factors ; Immunoglobulin G
Czasopismo naukowe
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Tytuł:
Evolution of HIV-1 envelope towards reduced neutralization sensitivity, as demonstrated by contemporary HIV-1 subtype B from the United States.
Autorzy:
Wieczorek L; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, United States of America.
Sanders-Buell E; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, United States of America.
Zemil M; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, United States of America.
Lewitus E; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, United States of America.
Kavusak E; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, United States of America.
Heller J; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, United States of America.
Molnar S; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, United States of America.
Rao M; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, United States of America.
Smith G; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, United States of America.
Bose M; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, United States of America.
Nguyen A; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, United States of America.
Dhungana A; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, United States of America.
Okada K; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, United States of America.
Parisi K; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, United States of America.
Silas D; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, United States of America.
Slike B; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, United States of America.
Ganesan A; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, United States of America.; Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America.; Walter Reed National Military Medical Center, Bethesda, Maryland, United States of America.
Okulicz J; Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America.; Brooke Army Medical Center, Fort Sam Houston, San Antonio, Texas, United States of America.
Lalani T; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, United States of America.; Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America.; Naval Medical Center Portsmouth, Portsmouth, Virginia, United States of America.
Agan BK; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, United States of America.; Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America.
Crowell TA; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, United States of America.
Darden J; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, United States of America.; Diagnostics and Countermeasures Branch, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America.
Rolland M; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, United States of America.
Vasan S; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, United States of America.
Ake J; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America.
Krebs SJ; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America.
Peel S; Diagnostics and Countermeasures Branch, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America.
Tovanabutra S; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America.; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, United States of America.
Polonis VR; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America.
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Źródło:
PLoS pathogens [PLoS Pathog] 2023 Dec 06; Vol. 19 (12), pp. e1011780. Date of Electronic Publication: 2023 Dec 06 (Print Publication: 2023).
Typ publikacji:
Meta-Analysis; Journal Article
MeSH Terms:
HIV Infections*
HIV-1*/genetics
HIV Seropositivity*
Humans ; United States/epidemiology ; HIV Antibodies ; Neutralization Tests ; env Gene Products, Human Immunodeficiency Virus/genetics ; Antibodies, Neutralizing ; Pandemics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Wyświetlanie 1-20 z 53007

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