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Tytuł :
Design and characterization of a germ-line targeting soluble, native-like, trimeric HIV-1 Env lacking key glycans from the V1V2-loop.
Autorzy :
Ahmed S; Infection and Immunity, Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India. Electronic address: .
Shrivastava T; Infection and Immunity, Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India.
Kumar R; Infection and Immunity, Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India.
Kumar M; Kusuma School of Biological Sciences, Indian Institute of Technology-Delhi, Hauz Khas, New Delhi, India.
Banerjee M; Kusuma School of Biological Sciences, Indian Institute of Technology-Delhi, Hauz Khas, New Delhi, India.
Kumar N; Infection and Immunity, Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India.
Bansal M; Infection and Immunity, Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India.
Das S; Infection and Immunity, Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India.
Samal S; Infection and Immunity, Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India.
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Źródło :
Biochimica et biophysica acta. General subjects [Biochim Biophys Acta Gen Subj] 2021 Jan; Vol. 1865 (1), pp. 129733. Date of Electronic Publication: 2020 Sep 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibodies, Neutralizing/*immunology
HIV Infections/*virology
HIV-1/*immunology
Polysaccharides/*immunology
env Gene Products, Human Immunodeficiency Virus/*immunology
Cell Line ; Epitopes/chemistry ; Epitopes/genetics ; Epitopes/immunology ; HIV Infections/immunology ; HIV-1/chemistry ; HIV-1/genetics ; Humans ; Models, Molecular ; Polysaccharides/chemistry ; Polysaccharides/genetics ; Protein Conformation ; Protein Multimerization ; Protein Stability ; env Gene Products, Human Immunodeficiency Virus/chemistry ; env Gene Products, Human Immunodeficiency Virus/genetics
Czasopismo naukowe
Tytuł :
Factors that mold the nuclear landscape of HIV-1 integration.
Autorzy :
Bedwell GJ; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
Engelman AN; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2021 Jan 25; Vol. 49 (2), pp. 621-635.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Review
MeSH Terms :
Host-Pathogen Interactions*
Virus Integration*/genetics
Virus Integration*/physiology
HIV-1/*physiology
Human Immunodeficiency Virus Proteins/*metabolism
Active Transport, Cell Nucleus ; Adaptor Proteins, Signal Transducing/deficiency ; Adaptor Proteins, Signal Transducing/physiology ; Capsid Proteins/metabolism ; Cell Nucleus/metabolism ; Cell Nucleus/virology ; Chromatin/genetics ; Chromatin/metabolism ; Cytoplasm/metabolism ; Cytoplasm/virology ; Cytoskeletal Proteins/metabolism ; HIV Reverse Transcriptase/physiology ; HIV-1/enzymology ; HIV-1/genetics ; Human Immunodeficiency Virus Proteins/genetics ; Humans ; Interphase ; Models, Molecular ; Multiprotein Complexes/metabolism ; Nuclear Pore/metabolism ; Nuclear Proteins/metabolism ; Protein Conformation ; Protein Domains ; Transcription Factors/deficiency ; Transcription Factors/physiology ; Virus Latency ; Virus Replication ; mRNA Cleavage and Polyadenylation Factors/deficiency ; mRNA Cleavage and Polyadenylation Factors/physiology
Czasopismo naukowe
Tytuł :
Mutational networks of escape from transmitted HIV-1 infection.
Autorzy :
Akand EH; School of Mathematics and Statistics, UNSW Sydney, Kensington, NSW, Australia.
Maher SJ; College of Engineering, Mathematical and Physical Sciences, University of Exeter, Exeter, United Kingdom.
Murray JM; School of Mathematics and Statistics, UNSW Sydney, Kensington, NSW, Australia.
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Źródło :
PloS one [PLoS One] 2020 Dec 07; Vol. 15 (12), pp. e0243391. Date of Electronic Publication: 2020 Dec 07 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
HIV Envelope Protein gp160/*genetics
HIV Infections/*genetics
HIV-1/*genetics
env Gene Products, Human Immunodeficiency Virus/*genetics
Computational Biology ; Glycosylation ; HIV Envelope Protein gp160/immunology ; HIV Infections/immunology ; HIV Infections/virology ; HIV-1/pathogenicity ; Humans ; Immune Evasion/genetics ; Immunity/genetics ; Immunity/immunology ; Mutation/genetics ; Protein Binding/genetics ; env Gene Products, Human Immunodeficiency Virus/immunology
Czasopismo naukowe
Tytuł :
Characteristics of HIV-1 env genes from Chinese chronically infected donors with highly broad cross-neutralizing activity.
Autorzy :
Sha SS; State Key Laboratory of Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, China. Electronic address: .
Dai Z; State Key Laboratory of Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, China; The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, 450052, Henan, China. Electronic address: .
Wei QZ; State Key Laboratory of Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, China. Electronic address: .
Tao HX; State Key Laboratory of Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, China; Human Retrovirus Pathogenesis Section, Vaccine Branch, Center for Cancer Research, National Cancer Institute, Frederick, MD, United States. Electronic address: .
Yuan HY; State Key Laboratory of Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, China. Electronic address: .
Li R; State Key Laboratory of Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, China. Electronic address: .
Ying L; State Key Laboratory of Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, China. Electronic address: .
Li Ying M; State Key Laboratory of Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, China. Electronic address: .
Ming SY; State Key Laboratory of Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, China. Electronic address: .
Xue HK; State Key Laboratory of Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, China. Electronic address: .
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Źródło :
Virology [Virology] 2020 Dec; Vol. 551, pp. 16-25. Date of Electronic Publication: 2020 Sep 28.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Broadly Neutralizing Antibodies/*immunology
HIV Antibodies/*immunology
HIV Infections/*immunology
env Gene Products, Human Immunodeficiency Virus/*genetics
China/epidemiology ; Chronic Disease ; Cohort Studies ; Cross Reactions ; Cross-Sectional Studies ; HIV Infections/virology ; HIV-1/genetics ; HIV-1/immunology ; Humans ; env Gene Products, Human Immunodeficiency Virus/immunology
Czasopismo naukowe
Tytuł :
Loss of Nef-mediated CD3 down-regulation in the HIV-1 lineage increases viral infectivity and spread.
Autorzy :
Mesner D; Division of Infection and Immunity, University College London, London WC1E 6BT, United Kingdom.
Hotter D; Institute of Molecular Virology, Ulm University Medical Center, 89081 Ulm, Germany.
Kirchhoff F; Institute of Molecular Virology, Ulm University Medical Center, 89081 Ulm, Germany.
Jolly C; Division of Infection and Immunity, University College London, London WC1E 6BT, United Kingdom; .
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Mar 31; Vol. 117 (13), pp. 7382-7391. Date of Electronic Publication: 2020 Mar 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
HIV-1/*metabolism
HIV-1/*pathogenicity
nef Gene Products, Human Immunodeficiency Virus/*metabolism
CD3 Complex/metabolism ; CD4 Antigens/metabolism ; CD4-Positive T-Lymphocytes ; Down-Regulation ; HIV Seropositivity ; HIV-1/genetics ; Humans ; Immune Evasion ; Lymphocyte Activation ; Membrane Proteins/metabolism ; Primary Cell Culture ; Simian Immunodeficiency Virus/pathogenicity ; T-Lymphocytes/immunology ; Viral Regulatory and Accessory Proteins/metabolism ; Virion/metabolism ; Virus Replication ; env Gene Products, Human Immunodeficiency Virus/immunology ; env Gene Products, Human Immunodeficiency Virus/metabolism ; nef Gene Products, Human Immunodeficiency Virus/genetics
Czasopismo naukowe
Tytuł :
HIV-1 Lethality and Loss of Env Protein Expression Induced by Single Synonymous Substitutions in the Virus Genome Intronic-Splicing Silencer.
Autorzy :
Jordan-Paiz A; IrsiCaixa AIDS Research Institute, Hospital Universitari Germans Trias I Pujol, Universitat Autònoma de Barcelona, Badalona, Spain.
Nevot M; IrsiCaixa AIDS Research Institute, Hospital Universitari Germans Trias I Pujol, Universitat Autònoma de Barcelona, Badalona, Spain.
Lamkiewicz K; RNA Bioinformatics and High-Throughput Analysis, Friedrich Schiller University, Jena, Germany.; European Virus Bioinformatics Center, Jena, Germany.
Lataretu M; RNA Bioinformatics and High-Throughput Analysis, Friedrich Schiller University, Jena, Germany.
Franco S; IrsiCaixa AIDS Research Institute, Hospital Universitari Germans Trias I Pujol, Universitat Autònoma de Barcelona, Badalona, Spain.
Marz M; RNA Bioinformatics and High-Throughput Analysis, Friedrich Schiller University, Jena, Germany.; European Virus Bioinformatics Center, Jena, Germany.
Martinez MA; IrsiCaixa AIDS Research Institute, Hospital Universitari Germans Trias I Pujol, Universitat Autònoma de Barcelona, Badalona, Spain .
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Źródło :
Journal of virology [J Virol] 2020 Oct 14; Vol. 94 (21). Date of Electronic Publication: 2020 Oct 14 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Genome, Viral*
Silent Mutation*
HIV-1/*genetics
Virus Replication/*genetics
env Gene Products, Human Immunodeficiency Virus/*chemistry
Base Pairing ; Base Sequence ; CD4-Positive T-Lymphocytes/metabolism ; CD4-Positive T-Lymphocytes/virology ; Cell Line ; Codon ; Exons ; HEK293 Cells ; HIV-1/metabolism ; Humans ; Introns ; RNA Folding ; RNA Splicing ; Structure-Activity Relationship ; Thermodynamics ; env Gene Products, Human Immunodeficiency Virus/genetics ; env Gene Products, Human Immunodeficiency Virus/metabolism
Czasopismo naukowe
Tytuł :
Replication of HIV-1 envelope protein cytoplasmic domain variants in permissive and restrictive cells.
Autorzy :
Staubus AO; Department of Molecular Microbiology and Immunology, Oregon Health and Sciences University, 3181 SW Sam Jackson Park Road, Portland, OR, 97239, USA.
Alfadhli A; Department of Molecular Microbiology and Immunology, Oregon Health and Sciences University, 3181 SW Sam Jackson Park Road, Portland, OR, 97239, USA.
Barklis RL; Department of Molecular Microbiology and Immunology, Oregon Health and Sciences University, 3181 SW Sam Jackson Park Road, Portland, OR, 97239, USA.
Barklis E; Department of Molecular Microbiology and Immunology, Oregon Health and Sciences University, 3181 SW Sam Jackson Park Road, Portland, OR, 97239, USA. Electronic address: .
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Źródło :
Virology [Virology] 2019 Dec; Vol. 538, pp. 1-10. Date of Electronic Publication: 2019 Sep 18.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Virus Replication*
HIV Infections/*virology
HIV-1/*physiology
env Gene Products, Human Immunodeficiency Virus/*chemistry
env Gene Products, Human Immunodeficiency Virus/*metabolism
Cell Membrane/virology ; HIV-1/chemistry ; HIV-1/genetics ; HeLa Cells ; Humans ; Protein Domains ; Virion/chemistry ; Virion/genetics ; Virion/physiology ; Virus Assembly ; env Gene Products, Human Immunodeficiency Virus/genetics ; gag Gene Products, Human Immunodeficiency Virus/genetics ; gag Gene Products, Human Immunodeficiency Virus/metabolism
Czasopismo naukowe
Tytuł :
Functional and Structural Insights into a Vif/PPP2R5 Complex Elucidated Using Patient HIV-1 Isolates and Computational Modeling.
Autorzy :
Salamango DJ; Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota, USA .; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA.; Institute for Molecular Virology, University of Minnesota, Minneapolis, Minnesota, USA.
McCann JL; Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota, USA.; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA.; Institute for Molecular Virology, University of Minnesota, Minneapolis, Minnesota, USA.; Howard Hughes Medical Institute, University of Minnesota, Minneapolis, Minnesota, USA.
Demir Ö; Department of Chemistry and Biochemistry, University of San Diego, La Jolla, California, USA.
Becker JT; Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota, USA.; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA.; Institute for Molecular Virology, University of Minnesota, Minneapolis, Minnesota, USA.
Wang J; Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota, USA.; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA.; Institute for Molecular Virology, University of Minnesota, Minneapolis, Minnesota, USA.; Department of Virology and Infectious Disease, Rockefeller University, New York, New York, USA.
Lingappa JR; Department of Global Health, University of Washington, Seattle, Washington, USA.; Department of Medicine, University of Washington, Seattle, Washington, USA.; Department of Pediatrics, University of Washington, Seattle, Washington, USA.
Temiz NA; Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota, USA.; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA.; Institute for Molecular Virology, University of Minnesota, Minneapolis, Minnesota, USA.
Brown WL; Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota, USA.; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA.; Institute for Molecular Virology, University of Minnesota, Minneapolis, Minnesota, USA.
Amaro RE; Department of Chemistry and Biochemistry, University of San Diego, La Jolla, California, USA.
Harris RS; Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota, USA .; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA.; Institute for Molecular Virology, University of Minnesota, Minneapolis, Minnesota, USA.; Howard Hughes Medical Institute, University of Minnesota, Minneapolis, Minnesota, USA.
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Źródło :
Journal of virology [J Virol] 2020 Oct 14; Vol. 94 (21). Date of Electronic Publication: 2020 Oct 14 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
APOBEC-3G Deaminase/*chemistry
HIV-1/*genetics
Protein Phosphatase 2/*chemistry
vif Gene Products, Human Immunodeficiency Virus/*chemistry
APOBEC-3G Deaminase/genetics ; APOBEC-3G Deaminase/metabolism ; Amino Acid Sequence ; Amino Acid Substitution ; Binding Sites ; Gene Expression ; Gene Expression Regulation ; Genetic Vectors/chemistry ; Genetic Vectors/metabolism ; HEK293 Cells ; HIV Infections/virology ; HIV-1/isolation & purification ; HIV-1/metabolism ; HeLa Cells ; Host-Pathogen Interactions/genetics ; Humans ; Kinetics ; Models, Molecular ; Mutation ; Protein Binding ; Protein Interaction Domains and Motifs ; Protein Phosphatase 2/genetics ; Protein Phosphatase 2/metabolism ; Protein Structure, Secondary ; Proteolysis ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Signal Transduction ; Substrate Specificity ; vif Gene Products, Human Immunodeficiency Virus/genetics ; vif Gene Products, Human Immunodeficiency Virus/metabolism
Czasopismo naukowe
Tytuł :
In Vitro Quantification of the Effects of IP6 and Other Small Polyanions on Immature HIV-1 Particle Assembly and Core Stability.
Autorzy :
Dostálková A; Department of Biotechnology, University of Chemistry and Technology, Prague, Prague, Czech Republic.
Kaufman F; Department of Biotechnology, University of Chemistry and Technology, Prague, Prague, Czech Republic.
Křížová I; Department of Biotechnology, University of Chemistry and Technology, Prague, Prague, Czech Republic.
Vokatá B; Department of Biochemistry and Microbiology, University of Chemistry and Technology, Prague, Prague, Czech Republic.
Ruml T; Department of Biochemistry and Microbiology, University of Chemistry and Technology, Prague, Prague, Czech Republic.
Rumlová M; Department of Biotechnology, University of Chemistry and Technology, Prague, Prague, Czech Republic .
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Źródło :
Journal of virology [J Virol] 2020 Sep 29; Vol. 94 (20). Date of Electronic Publication: 2020 Sep 29 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Virus Assembly*
HIV-1/*chemistry
Polymers/*chemistry
gag Gene Products, Human Immunodeficiency Virus/*chemistry
Amino Acid Substitution ; HIV-1/genetics ; Mutation, Missense ; Structure-Activity Relationship ; gag Gene Products, Human Immunodeficiency Virus/genetics ; gag Gene Products, Human Immunodeficiency Virus/metabolism
Czasopismo naukowe
Tytuł :
Modification of lipid rafts by extracellular vesicles carrying HIV-1 protein Nef induces redistribution of amyloid precursor protein and Tau, causing neuronal dysfunction.
Autorzy :
Ditiatkovski M; Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.
Mukhamedova N; Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.
Dragoljevic D; Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.
Hoang A; Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.
Low H; Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.
Pushkarsky T; Department of Microbiology, Immunology and Tropical Medicine, George Washington University School of Medicine and Health Sciences, Washington, D.C., USA.
Fu Y; Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.
Carmichael I; Department of Micro Imaging, Monash University, Melbourne, Victoria, Australia.
Hill AF; Department of Biochemistry and Genetics, Louisiana Trobe Institute for Molecular Science, Louisiana Trobe University, Bundoora, Victoria, Australia.
Murphy AJ; Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.
Bukrinsky M; Department of Microbiology, Immunology and Tropical Medicine, George Washington University School of Medicine and Health Sciences, Washington, D.C., USA.
Sviridov D; Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia .; Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia.
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2020 Sep 18; Vol. 295 (38), pp. 13377-13392. Date of Electronic Publication: 2020 Jul 30.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Amyloid beta-Protein Precursor/*metabolism
HIV Infections/*metabolism
HIV-1/*metabolism
Membrane Microdomains/*metabolism
Neurocognitive Disorders/*metabolism
Neurons/*metabolism
nef Gene Products, Human Immunodeficiency Virus/*metabolism
tau Proteins/*metabolism
ATP Binding Cassette Transporter 1/genetics ; ATP Binding Cassette Transporter 1/metabolism ; Amyloid beta-Peptides/genetics ; Amyloid beta-Peptides/metabolism ; Amyloid beta-Protein Precursor/genetics ; Animals ; Cell Line, Tumor ; Cholesterol/genetics ; Cholesterol/metabolism ; HIV Infections/complications ; HIV Infections/genetics ; HIV Infections/pathology ; HIV-1/genetics ; Humans ; Membrane Microdomains/genetics ; Mice ; Neurocognitive Disorders/etiology ; Neurocognitive Disorders/genetics ; Neurocognitive Disorders/pathology ; Neurons/pathology ; Peptide Fragments/genetics ; Peptide Fragments/metabolism ; nef Gene Products, Human Immunodeficiency Virus/genetics ; tau Proteins/genetics
Czasopismo naukowe
Tytuł :
Infection with multiple HIV-1 founder variants is associated with lower viral replicative capacity, faster CD4+ T cell decline and increased immune activation during acute infection.
Autorzy :
Macharia GN; Department of Medicine, Imperial College London, London, United Kingdom.; IAVI Human Immunology Laboratory, London, United Kingdom.
Yue L; Emory Vaccine Centre, Yerkes National Primate Research Centre, Emory University, Atlanta, GA, United States of America.
Staller E; Department of Medicine, Imperial College London, London, United Kingdom.; IAVI Human Immunology Laboratory, London, United Kingdom.
Dilernia D; Emory Vaccine Centre, Yerkes National Primate Research Centre, Emory University, Atlanta, GA, United States of America.
Wilkins D; Emory Vaccine Centre, Yerkes National Primate Research Centre, Emory University, Atlanta, GA, United States of America.
Song H; Emory Vaccine Centre, Yerkes National Primate Research Centre, Emory University, Atlanta, GA, United States of America.
McGowan E; Department of Medicine, Imperial College London, London, United Kingdom.; IAVI Human Immunology Laboratory, London, United Kingdom.
King D; Department of Medicine, Imperial College London, London, United Kingdom.; IAVI Human Immunology Laboratory, London, United Kingdom.
Fast P; IAVI, New York, NY, United States of America.
Imami N; Department of Medicine, Imperial College London, London, United Kingdom.
Price MA; IAVI, New York, NY, United States of America.; Department of Epidemiology and Biostatistics, University of California at San Francisco, San Francisco, CA, United States of America.
Sanders EJ; Kenya Medical Research Institute-Wellcome Trust, Kilifi, Kenya.; Nuffield Department of Clinical Medicine, Centre for Clinical Vaccinology and Tropical Medicine, University of Oxford, Headington, United Kingdom.
Hunter E; Emory Vaccine Centre, Yerkes National Primate Research Centre, Emory University, Atlanta, GA, United States of America.; Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA, United States of America.
Gilmour J; Department of Medicine, Imperial College London, London, United Kingdom.; IAVI Human Immunology Laboratory, London, United Kingdom.
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Źródło :
PLoS pathogens [PLoS Pathog] 2020 Sep 04; Vol. 16 (9), pp. e1008853. Date of Electronic Publication: 2020 Sep 04 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Founder Effect*
HIV Infections*/genetics
HIV Infections*/immunology
HIV Infections*/pathology
Virus Replication*/genetics
Virus Replication*/immunology
gag Gene Products, Human Immunodeficiency Virus*/genetics
gag Gene Products, Human Immunodeficiency Virus*/immunology
CD4-Positive T-Lymphocytes/*immunology
HIV-1/*physiology
Acute Disease ; Adolescent ; Adult ; B-Lymphocytes/immunology ; B-Lymphocytes/pathology ; CD4-Positive T-Lymphocytes/pathology ; CD4-Positive T-Lymphocytes/virology ; Female ; Humans ; Male ; Middle Aged ; Viremia/genetics ; Viremia/immunology ; Viremia/pathology
Czasopismo naukowe
Tytuł :
Sensitivity to monoclonal antibody 447-52D and an open env trimer conformation correlate poorly with inhibition of HIV-1 infectivity by SERINC5.
Autorzy :
Angerstein AO; Department of Biological Sciences, University of California San Diego, 9500 Gilman Dr, La Jolla, CA, 92093, USA; VA San Diego Healthcare System, 3350 La Jolla Village Dr, San Diego, CA, 92161, USA.
Stoneham CA; VA San Diego Healthcare System, 3350 La Jolla Village Dr, San Diego, CA, 92161, USA; Department of Medicine, University of California San Diego, 9500 Gilman Dr, La Jolla, CA, 92093, USA.
Ramirez PW; VA San Diego Healthcare System, 3350 La Jolla Village Dr, San Diego, CA, 92161, USA; Department of Medicine, University of California San Diego, 9500 Gilman Dr, La Jolla, CA, 92093, USA.
Guatelli JC; VA San Diego Healthcare System, 3350 La Jolla Village Dr, San Diego, CA, 92161, USA; Department of Medicine, University of California San Diego, 9500 Gilman Dr, La Jolla, CA, 92093, USA.
Vollbrecht T; VA San Diego Healthcare System, 3350 La Jolla Village Dr, San Diego, CA, 92161, USA; Department of Medicine, University of California San Diego, 9500 Gilman Dr, La Jolla, CA, 92093, USA. Electronic address: .
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Źródło :
Virology [Virology] 2020 Sep; Vol. 548, pp. 73-81. Date of Electronic Publication: 2020 Jun 17.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Antibodies, Monoclonal/*immunology
HIV Antibodies/*immunology
HIV Infections/*immunology
HIV-1/*immunology
Membrane Proteins/*immunology
env Gene Products, Human Immunodeficiency Virus/*chemistry
env Gene Products, Human Immunodeficiency Virus/*immunology
Antibodies, Neutralizing/immunology ; HIV Infections/genetics ; HIV Infections/virology ; HIV-1/chemistry ; HIV-1/genetics ; HIV-1/physiology ; Humans ; Membrane Proteins/chemistry ; Membrane Proteins/genetics ; Mutation ; env Gene Products, Human Immunodeficiency Virus/genetics
Czasopismo naukowe
Tytuł :
Neutralizing Antibody Responses Induced by HIV-1 Envelope Glycoprotein SOSIP Trimers Derived from Elite Neutralizers.
Autorzy :
Schorcht A; Department of Medical Microbiology, Amsterdam Infection & Immunity Institute (AI&II), Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.
van den Kerkhof TLGM; Department of Medical Microbiology, Amsterdam Infection & Immunity Institute (AI&II), Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.; Department of Experimental Immunology, Amsterdam Infection & Immunity Institute (AI&II), Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.
Cottrell CA; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, USA.
Allen JD; School of Biological Science, University of Southampton, Southampton, United Kingdom.
Torres JL; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, USA.
Behrens AJ; School of Biological Science, University of Southampton, Southampton, United Kingdom.
Schermer EE; Department of Medical Microbiology, Amsterdam Infection & Immunity Institute (AI&II), Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.
Burger JA; Department of Medical Microbiology, Amsterdam Infection & Immunity Institute (AI&II), Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.
de Taeye SW; Department of Medical Microbiology, Amsterdam Infection & Immunity Institute (AI&II), Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.
Torrents de la Peña A; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, USA.
Bontjer I; Department of Medical Microbiology, Amsterdam Infection & Immunity Institute (AI&II), Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.
Gumbs S; Department of Medical Microbiology, Amsterdam Infection & Immunity Institute (AI&II), Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.
Ozorowski G; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, USA.
LaBranche CC; Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA.
de Val N; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, USA.; Center for Molecular Microscopy, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick National Laboratory, Leidos Biomedical Research Inc., Frederick, Maryland, USA.
Yasmeen A; Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, New York, USA.
Klasse PJ; Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, New York, USA.
Montefiori DC; Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA.
Moore JP; Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, New York, USA.
Schuitemaker H; Janssen Pharmaceuticals, Leiden, the Netherlands.
Crispin M; School of Biological Science, University of Southampton, Southampton, United Kingdom.
van Gils MJ; Department of Medical Microbiology, Amsterdam Infection & Immunity Institute (AI&II), Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.
Ward AB; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, USA.
Sanders RW; Department of Medical Microbiology, Amsterdam Infection & Immunity Institute (AI&II), Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands .; Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, New York, USA.
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Źródło :
Journal of virology [J Virol] 2020 Nov 23; Vol. 94 (24). Date of Electronic Publication: 2020 Nov 23 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibodies, Neutralizing/*immunology
Antigens, Viral/*immunology
HIV Antibodies/*immunology
HIV Infections/*immunology
HIV-1/*immunology
env Gene Products, Human Immunodeficiency Virus/*immunology
AIDS Vaccines/immunology ; Animals ; Antibodies, Neutralizing/chemistry ; Antigens, Viral/chemistry ; Cryoelectron Microscopy ; Epitopes/immunology ; Glycoproteins ; HIV Infections/virology ; Immunization ; Rabbits ; Recombinant Proteins/immunology ; env Gene Products, Human Immunodeficiency Virus/genetics
Czasopismo naukowe
Tytuł :
Native mass spectrometry reveals the initial binding events of HIV-1 rev to RRE stem II RNA.
Autorzy :
Schneeberger EM; Institute of Organic Chemistry and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innrain 80/82, 6020, Innsbruck, Austria.; Boston Children's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
Halper M; Institute of Organic Chemistry and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innrain 80/82, 6020, Innsbruck, Austria.
Palasser M; Institute of Organic Chemistry and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innrain 80/82, 6020, Innsbruck, Austria.
Heel SV; Institute of Organic Chemistry and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innrain 80/82, 6020, Innsbruck, Austria.
Vušurović J; Institute of Organic Chemistry and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innrain 80/82, 6020, Innsbruck, Austria.
Plangger R; Institute of Organic Chemistry and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innrain 80/82, 6020, Innsbruck, Austria.
Juen M; Institute of Organic Chemistry and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innrain 80/82, 6020, Innsbruck, Austria.; Roche Diagnostics GmbH, 82377, Penzberg, Germany.
Kreutz C; Institute of Organic Chemistry and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innrain 80/82, 6020, Innsbruck, Austria.
Breuker K; Institute of Organic Chemistry and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innrain 80/82, 6020, Innsbruck, Austria. .
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Źródło :
Nature communications [Nat Commun] 2020 Nov 13; Vol. 11 (1), pp. 5750. Date of Electronic Publication: 2020 Nov 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
HIV-1/*metabolism
RNA, Viral/*metabolism
rev Gene Products, Human Immunodeficiency Virus/*metabolism
Binding Sites ; Genes, env ; HIV-1/chemistry ; HIV-1/genetics ; Mass Spectrometry ; Nucleic Acid Conformation ; Protein Multimerization ; RNA, Viral/chemistry ; RNA, Viral/genetics ; rev Gene Products, Human Immunodeficiency Virus/chemistry
Czasopismo naukowe
Tytuł :
Visualization of the HIV-1 Env glycan shield across scales.
Autorzy :
Berndsen ZT; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037.; The International AIDS Vaccine Initiative Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037.; Scripps Consortium For HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037.
Chakraborty S; Theoretical Biology and Biophysics Group, Los Alamos National Laboratory, Los Alamos, NM 87545.; Center for Nonlinear Studies, Los Alamos National Laboratory, Los Alamos, NM 87545.
Wang X; The International AIDS Vaccine Initiative Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037.; Scripps Consortium For HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037.; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037.
Cottrell CA; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037.; The International AIDS Vaccine Initiative Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037.; Scripps Consortium For HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037.
Torres JL; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037.
Diedrich JK; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037.
López CA; Theoretical Biology and Biophysics Group, Los Alamos National Laboratory, Los Alamos, NM 87545.
Yates JR 3rd; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037.
van Gils MJ; Department of Medical Microbiology, Amsterdam University Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands.
Paulson JC; The International AIDS Vaccine Initiative Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037.; Scripps Consortium For HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037.; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037.; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037.
Gnanakaran S; Theoretical Biology and Biophysics Group, Los Alamos National Laboratory, Los Alamos, NM 87545; .
Ward AB; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037; .; The International AIDS Vaccine Initiative Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037.; Scripps Consortium For HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Nov 10; Vol. 117 (45), pp. 28014-28025. Date of Electronic Publication: 2020 Oct 22.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
HIV-1/*immunology
Polysaccharides/*metabolism
env Gene Products, Human Immunodeficiency Virus/*immunology
Antibodies, Neutralizing/immunology ; Antibody Formation ; Computer Simulation ; Cryoelectron Microscopy/methods ; Epitopes/chemistry ; Glycosylation ; HIV Antibodies/immunology ; HIV Envelope Protein gp120/metabolism ; HIV Seropositivity ; HIV-1/metabolism ; Humans ; Immune Evasion/immunology ; Mass Spectrometry/methods ; Models, Molecular ; env Gene Products, Human Immunodeficiency Virus/chemistry
Czasopismo naukowe
Tytuł :
Unpaired Guanosines in the 5' Untranslated Region of HIV-1 RNA Act Synergistically To Mediate Genome Packaging.
Autorzy :
Nikolaitchik OA; Viral Recombination Section, HIV Dynamics and Replication Program, National Cancer Institute, Frederick, Maryland, USA.
Somoulay X; Viral Recombination Section, HIV Dynamics and Replication Program, National Cancer Institute, Frederick, Maryland, USA.
Rawson JMO; Viral Recombination Section, HIV Dynamics and Replication Program, National Cancer Institute, Frederick, Maryland, USA.
Yoo JA; Viral Recombination Section, HIV Dynamics and Replication Program, National Cancer Institute, Frederick, Maryland, USA.
Pathak VK; Viral Mutation Section, HIV Dynamics and Replication Program, National Cancer Institute, Frederick, Maryland, USA.
Hu WS; Viral Recombination Section, HIV Dynamics and Replication Program, National Cancer Institute, Frederick, Maryland, USA .
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Źródło :
Journal of virology [J Virol] 2020 Oct 14; Vol. 94 (21). Date of Electronic Publication: 2020 Oct 14 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Intramural
MeSH Terms :
5' Untranslated Regions*
Viral Genome Packaging*
HIV-1/*genetics
Nucleocapsid Proteins/*genetics
RNA, Viral/*genetics
Virion/*genetics
gag Gene Products, Human Immunodeficiency Virus/*genetics
Animals ; Base Pairing ; Binding Sites ; Encephalomyocarditis virus/genetics ; Encephalomyocarditis virus/metabolism ; Genetic Engineering/methods ; Genome, Viral ; Guanosine/chemistry ; Guanosine/metabolism ; HEK293 Cells ; HIV-1/metabolism ; Humans ; Mice ; Mutation ; Nucleic Acid Conformation ; Nucleocapsid Proteins/metabolism ; Nucleotide Motifs ; Protein Binding ; RNA, Viral/chemistry ; RNA, Viral/metabolism ; Vesiculovirus/genetics ; Vesiculovirus/metabolism ; Virion/metabolism ; gag Gene Products, Human Immunodeficiency Virus/metabolism
Czasopismo naukowe
Tytuł :
Evolution of a concept: From accessory protein to key virulence factor, the case of HIV-1 Vpr.
Autorzy :
Wallet C; University of Strasbourg, Research Unit7292, DHPI, IUT Louis Pasteur, Schiltigheim, France.
Rohr O; University of Strasbourg, Research Unit7292, DHPI, IUT Louis Pasteur, Schiltigheim, France.
Schwartz C; University of Strasbourg, Research Unit7292, DHPI, IUT Louis Pasteur, Schiltigheim, France. Electronic address: .
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Źródło :
Biochemical pharmacology [Biochem Pharmacol] 2020 Oct; Vol. 180, pp. 114128. Date of Electronic Publication: 2020 Jun 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Polymorphism, Genetic*
Transcription, Genetic*
Virulence Factors/*genetics
vpr Gene Products, Human Immunodeficiency Virus/*genetics
Amino Acid Sequence ; Apoptosis/genetics ; Cell Cycle/genetics ; Disease Progression ; HIV Infections/immunology ; HIV Infections/virology ; Humans ; Mutagenesis, Site-Directed ; T-Lymphocytes/immunology ; T-Lymphocytes/pathology ; T-Lymphocytes/virology ; Virulence Factors/physiology ; vpr Gene Products, Human Immunodeficiency Virus/physiology
Czasopismo naukowe
Tytuł :
A Stronger Transcription Regulatory Circuit of HIV-1C Drives the Rapid Establishment of Latency with Implications for the Direct Involvement of Tat.
Autorzy :
Chakraborty S; HIV-AIDS Laboratory, Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore, India.
Kabi M; HIV-AIDS Laboratory, Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore, India.
Ranga U; HIV-AIDS Laboratory, Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore, India .
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Źródło :
Journal of virology [J Virol] 2020 Sep 15; Vol. 94 (19). Date of Electronic Publication: 2020 Sep 15 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation, Viral*
Transcription, Genetic*
HIV-1/*genetics
HIV-1/*physiology
Virus Latency/*physiology
tat Gene Products, Human Immunodeficiency Virus/*metabolism
Binding Sites ; HIV Infections/genetics ; Humans ; Jurkat Cells ; NF-kappa B/metabolism ; Promoter Regions, Genetic ; Transcriptional Activation ; Virus Latency/genetics ; Virus Replication ; tat Gene Products, Human Immunodeficiency Virus/genetics
Czasopismo naukowe
Tytuł :
Variation in HIV-1 Nef function within and among viral subtypes reveals genetically separable antagonism of SERINC3 and SERINC5.
Autorzy :
Jin SW; Faculty of Health Sciences, Simon Fraser University, Burnaby, Canada.
Mwimanzi FM; Faculty of Health Sciences, Simon Fraser University, Burnaby, Canada.
Mann JK; HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa.
Bwana MB; Faculty of Medicine, Mbarara University of Science and Technology, Mbarara, Uganda.
Lee GQ; British Columbia Centre for Excellence in HIV/AIDS, Vancouver, Canada.
Brumme CJ; British Columbia Centre for Excellence in HIV/AIDS, Vancouver, Canada.; Department of Medicine, University of British Columbia, Vancouver, Canada.
Hunt PW; School of Medicine, University of California, San Francisco, United States of America.
Martin JN; School of Medicine, University of California, San Francisco, United States of America.
Bangsberg DR; School of Public Health, Oregon Health Science University, Portland, United States of America.
Ndung'u T; HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa.; Africa Health Research Institute, Durban, South Africa.; Ragon Institute of MGH, MIT, and Harvard University, Cambridge, United States of America.; Max Planck Institute for Infection Biology, Berlin, Germany.; Division of Infection and Immunity, University College London, London, United Kingdom.
Brumme ZL; Faculty of Health Sciences, Simon Fraser University, Burnaby, Canada.; British Columbia Centre for Excellence in HIV/AIDS, Vancouver, Canada.
Brockman MA; Faculty of Health Sciences, Simon Fraser University, Burnaby, Canada.; British Columbia Centre for Excellence in HIV/AIDS, Vancouver, Canada.; Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, Canada.
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Źródło :
PLoS pathogens [PLoS Pathog] 2020 Sep 14; Vol. 16 (9), pp. e1008813. Date of Electronic Publication: 2020 Sep 14 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Polymorphism, Genetic*
Virus Replication*
HIV Infections/*virology
HIV-1/*physiology
Membrane Glycoproteins/*antagonists & inhibitors
Membrane Proteins/*antagonists & inhibitors
nef Gene Products, Human Immunodeficiency Virus/*metabolism
HIV Infections/genetics ; HIV Infections/metabolism ; HIV Seropositivity ; Host-Pathogen Interactions ; Humans ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/genetics ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/metabolism ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/virology ; Tumor Cells, Cultured ; nef Gene Products, Human Immunodeficiency Virus/genetics
Czasopismo naukowe
Tytuł :
Higher frequencies of functional HIV-envelope-specific memory B cells are associated with nonprogressive HIV infection in Indian population.
Autorzy :
Dhande JR; Department of Immunology and Serology, National AIDS Research Institute, Pune, Maharashtra, India.
Saikia K
Singh DP
Bagul RD
Kulkarni SS
Ghate MV
Thakar MR
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Źródło :
AIDS (London, England) [AIDS] 2020 Sep 01; Vol. 34 (11), pp. 1603-1608.
Typ publikacji :
Journal Article
MeSH Terms :
env Gene Products, Human Immunodeficiency Virus*
B-Lymphocytes/*immunology
HIV Infections/*ethnology
HIV-1/*physiology
Antiretroviral Therapy, Highly Active ; Asian Continental Ancestry Group ; CD4 Lymphocyte Count ; Disease Progression ; HIV Infections/drug therapy ; HIV Infections/immunology ; HIV Infections/metabolism ; HIV Infections/virology ; HIV-1/immunology ; Humans ; India/epidemiology ; Viral Load
Czasopismo naukowe

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