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Tytuł :
Pterostilbene Nanoparticles Downregulate Hypoxia-Inducible Factors in Hepatoma Cells Under Hypoxic Conditions.
Autorzy :
Tzeng WS; Department of Radiology, Pingtung Christian Hospital, Pingtung, Taiwan.; Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung, Taiwan.
Teng WL; Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan.
Huang PH; School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan.
Lin TC; Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan.
Yen FL; Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung, Taiwan.; Department of Fragrance and Cosmetic Science, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan.; Drug Development and Value Creation Research Center, Kaohsiung Medical University, Kaohsiung, Taiwan.; Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
Shiue YL; Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung, Taiwan.
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Źródło :
International journal of nanomedicine [Int J Nanomedicine] 2021 Feb 05; Vol. 16, pp. 867-879. Date of Electronic Publication: 2021 Feb 05 (Print Publication: 2021).
Typ publikacji :
Journal Article
MeSH Terms :
Down-Regulation*/drug effects
Tumor Hypoxia*/drug effects
Carcinoma, Hepatocellular/*drug therapy
Hypoxia-Inducible Factor 1, alpha Subunit/*metabolism
Liver Neoplasms/*drug therapy
Nanoparticles/*chemistry
Stilbenes/*therapeutic use
Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Apoptosis/drug effects ; Carcinoma, Hepatocellular/pathology ; Cell Hypoxia/drug effects ; Cell Survival/drug effects ; Crystallization ; Drug Liberation ; Hep G2 Cells ; Humans ; Hydrogen Bonding ; Liver Neoplasms/pathology ; Neoplasm Invasiveness ; Particle Size ; Proton Magnetic Resonance Spectroscopy ; Solubility ; Spectroscopy, Fourier Transform Infrared ; Stilbenes/chemistry ; Stilbenes/pharmacology
Czasopismo naukowe
Tytuł :
Experimental Study on the Correlation between miRNA-373 and HIF-1 α , MMP-9, and VEGF in the Development of HIE.
Autorzy :
Liu CY; Department of Biochemistry and Molecular Biology, Jiamusi University School of Basic Medical Sciences, Jiamusi, China.; AnKang University, School of Medicine, Ankang, Shanxi Province 725000, China.
Al-Ward H; Department of Biochemistry and Molecular Biology, Jiamusi University School of Basic Medical Sciences, Jiamusi, China.
Ngaffo Mekontso F; Hainan University, Haikou, Hainan Province, China.
Liu N; Department of Biochemistry and Molecular Biology, Jiamusi University School of Basic Medical Sciences, Jiamusi, China.
Zeng HQ; First Affiliated Hospital of Xiamen University, Xiamen 361003, China.
Liu M; Beijing Friendship Hospital, Capital Medical University, Beijing 100000, China.
Yu ZR; Inner Mongolia Medical University, Hohhot, Inner Mongolia, China.
Zhang L; Jiamusi University, School of Clinical Medicine, Jiamusi, China.
Han YC; Jiamusi University, School of Clinical Medicine, Jiamusi, China.
Xu H; Department of Biochemistry and Molecular Biology, Jiamusi University School of Basic Medical Sciences, Jiamusi, China.
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Źródło :
BioMed research international [Biomed Res Int] 2021 May 03; Vol. 2021, pp. 5553486. Date of Electronic Publication: 2021 May 03 (Print Publication: 2021).
Typ publikacji :
Journal Article
MeSH Terms :
Hypoxia-Ischemia, Brain*/genetics
Hypoxia-Ischemia, Brain*/metabolism
Hypoxia-Ischemia, Brain*/physiopathology
Infant, Newborn, Diseases*/genetics
Infant, Newborn, Diseases*/metabolism
Infant, Newborn, Diseases*/physiopathology
Hypoxia-Inducible Factor 1, alpha Subunit/*metabolism
Matrix Metalloproteinase 9/*metabolism
MicroRNAs/*metabolism
Computational Biology ; Humans ; Hypoxia-Inducible Factor 1, alpha Subunit/blood ; Hypoxia-Inducible Factor 1, alpha Subunit/genetics ; Infant, Newborn ; Matrix Metalloproteinase 9/blood ; Matrix Metalloproteinase 9/genetics ; MicroRNAs/blood ; MicroRNAs/genetics ; Vascular Endothelial Growth Factor A/blood ; Vascular Endothelial Growth Factor A/genetics ; Vascular Endothelial Growth Factor A/metabolism
Czasopismo naukowe
Tytuł :
Delivery of siHIF-1α to Reconstruct Tumor Normoxic Microenvironment for Effective Chemotherapeutic and Photodynamic Anticancer Treatments.
Autorzy :
Chen X; National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, 610064, P. R. China.
Jin R; National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, 610064, P. R. China.
Jiang Q; National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, 610064, P. R. China.
Bi Q; National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, 610064, P. R. China.
He T; National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, 610064, P. R. China.
Song X; National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, 610064, P. R. China.
Barz M; Leiden Academic Center for Drug Research (LACDR), Leiden University, Einsteinweg 55, Leiden, 2333 CC, The Netherlands.; Institute of Organic Chemistry, Johannes Gutenberg-University, Mainz Duesbergweg 10-14, 55099, Mainz, Germany.
Ai H; National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, 610064, P. R. China.
Shuai X; PCFM Lab of Ministry of Education, School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou, 510275, P. R. China.
Nie Y; National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, 610064, P. R. China.
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Źródło :
Small (Weinheim an der Bergstrasse, Germany) [Small] 2021 Jun; Vol. 17 (25), pp. e2100609. Date of Electronic Publication: 2021 May 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Hypoxia*
Tumor Microenvironment*
Cell Hypoxia ; Cell Line, Tumor ; Humans ; Hypoxia-Inducible Factor 1, alpha Subunit ; Oxygen ; RNA, Small Interfering
Czasopismo naukowe
Tytuł :
HIF1α-Regulated Expression of the Fatty Acid Binding Protein Family Is Important for Hypoxic Reactivation of Kaposi's Sarcoma-Associated Herpesvirus.
Autorzy :
Singh RK; Department of Otorhinolaryngology-Head and Neck Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Bose D; Department of Otorhinolaryngology-Head and Neck Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Robertson ES; Department of Otorhinolaryngology-Head and Neck Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA .; The Tumor Virology Program, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
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Źródło :
Journal of virology [J Virol] 2021 May 24; Vol. 95 (12). Date of Electronic Publication: 2021 May 24 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Cell Hypoxia*
Fatty Acid-Binding Protein 7/*genetics
Fatty Acid-Binding Proteins/*genetics
Herpesvirus 8, Human/*physiology
Hypoxia-Inducible Factor 1, alpha Subunit/*metabolism
Tumor Suppressor Proteins/*genetics
Amino Acids/metabolism ; Antigens, Viral/genetics ; Antigens, Viral/metabolism ; Cell Line, Tumor ; Fatty Acid-Binding Protein 7/metabolism ; Fatty Acid-Binding Proteins/metabolism ; Fatty Acids/metabolism ; Gene Expression Regulation ; Gene Knockdown Techniques ; Humans ; Hypoxia-Inducible Factor 1, alpha Subunit/genetics ; Nuclear Proteins/genetics ; Nuclear Proteins/metabolism ; RNA Interference ; Receptors, Chemokine/genetics ; Receptors, Chemokine/metabolism ; Tumor Suppressor Proteins/metabolism ; Viral Proteins/genetics ; Viral Proteins/metabolism ; Virus Activation
Czasopismo naukowe
Tytuł :
Normoxic induction of HIF-1α by adenosine-A 2B R signaling in epicardial stromal cells formed after myocardial infarction.
Autorzy :
Hesse J; Department of Molecular Cardiology, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.
Groterath W; Department of Molecular Cardiology, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.
Owenier C; Department of Molecular Cardiology, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.
Steinhausen J; Department of Molecular Cardiology, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.
Ding Z; Department of Molecular Cardiology, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.
Steckel B; Department of Molecular Cardiology, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.
Czekelius C; Institute for Organic Chemistry and Macromolecular Chemistry, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.
Alter C; Department of Molecular Cardiology, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.
Marzoq A; Department of Molecular Cardiology, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.
Schrader J; Department of Molecular Cardiology, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.
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Źródło :
FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2021 May; Vol. 35 (5), pp. e21517.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Hypoxia*
Cardiotonic Agents/*metabolism
Hypoxia-Inducible Factor 1, alpha Subunit/*metabolism
Myocardial Infarction/*prevention & control
Pericardium/*metabolism
Receptor, Adenosine A2B/*metabolism
Stromal Cells/*metabolism
Animals ; Hypoxia-Inducible Factor 1, alpha Subunit/genetics ; Male ; Myocardial Infarction/etiology ; Myocardial Infarction/metabolism ; Myocardial Infarction/pathology ; Pericardium/pathology ; Rats ; Rats, Wistar ; Receptor, Adenosine A2B/genetics ; Stromal Cells/pathology
Czasopismo naukowe
Tytuł :
[Effect of hypoxia inducible factor 1α overexpression on differentiation of stem cells derived from human exfoliated deciduous teeth into vascular endothelial cells].
Autorzy :
Li Y; Department of Stomatology, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu Sichuan, 610036, P.R.China.
Chen D; Department of Stomatology, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu Sichuan, 610036, P.R.China.
Wu B; Department of Stomatology, Qingyang District Hospital of Traditional Chinese Medicine, Chengdu Sichuan, 610036, P.R.China.
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Źródło :
Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery [Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi] 2021 Jun 15; Vol. 35 (6), pp. 761-768.
Typ publikacji :
Journal Article
MeSH Terms :
Endothelial Cells*
Hypoxia-Inducible Factor 1, alpha Subunit*/genetics
Osteogenesis*
Cell Differentiation ; Child ; Humans ; Hypoxia ; Stem Cells ; Tooth, Deciduous
Czasopismo naukowe
Tytuł :
MiR-194-5p enhances the sensitivity of nonsmall-cell lung cancer to doxorubicin through targeted inhibition of hypoxia-inducible factor-1.
Autorzy :
Xia M; Department of Ultrasound, Children's Hospital of Nanjing Medical University, Nanjing, 210006, People's Republic of China.
Sheng L; Department of Blood Transfusion, Nanjing Benq Medical Center, Nanjing, 210021, People's Republic of China.
Qu W; Department of Nuclear Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing, 210006, People's Republic of China.
Xue X; Department of Nuclear Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing, 210006, People's Republic of China.
Chen H; Department of Nuclear Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing, 210006, People's Republic of China.
Zheng G; Department of Nuclear Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing, 210006, People's Republic of China.
Chen W; Laboratory Medical Center, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, 210000, People's Republic of China. .
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Źródło :
World journal of surgical oncology [World J Surg Oncol] 2021 Jun 14; Vol. 19 (1), pp. 174. Date of Electronic Publication: 2021 Jun 14.
Typ publikacji :
Journal Article
MeSH Terms :
Hypoxia-Inducible Factor 1*
Lung Neoplasms*/drug therapy
Lung Neoplasms*/genetics
MicroRNAs*/genetics
A549 Cells ; Cell Line, Tumor ; Doxorubicin/pharmacology ; Humans ; Hypoxia-Inducible Factor 1, alpha Subunit ; Prognosis
Czasopismo naukowe
Tytuł :
Ameliorative Effect of Ananas comosus on Cobalt Chloride-Induced Hypoxia in Caco2 cells via HIF-1α, GLUT 1, VEGF, ANG and FGF.
Autorzy :
Basavaraju AM; Food Quality Assurance, Defence Food Research Laboratory, Defence Research and Development Organisation, Ministry of Defence, Govt. of India, Siddarthanagar, Mysore, 570011, India.
Shivanna N; Food Quality Assurance, Defence Food Research Laboratory, Defence Research and Development Organisation, Ministry of Defence, Govt. of India, Siddarthanagar, Mysore, 570011, India. .
Yadavalli C; Food Quality Assurance, Defence Food Research Laboratory, Defence Research and Development Organisation, Ministry of Defence, Govt. of India, Siddarthanagar, Mysore, 570011, India.
Garlapati PK; Food Quality Assurance, Defence Food Research Laboratory, Defence Research and Development Organisation, Ministry of Defence, Govt. of India, Siddarthanagar, Mysore, 570011, India.
Raghavan AK; Food Quality Assurance, Defence Food Research Laboratory, Defence Research and Development Organisation, Ministry of Defence, Govt. of India, Siddarthanagar, Mysore, 570011, India.
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Źródło :
Biological trace element research [Biol Trace Elem Res] 2021 Apr; Vol. 199 (4), pp. 1345-1355. Date of Electronic Publication: 2020 Jul 11.
Typ publikacji :
Journal Article
MeSH Terms :
Ananas*/metabolism
Cell Hypoxia*
Cobalt*/toxicity
Caco-2 Cells ; Fibroblast Growth Factors ; Glucose Transporter Type 1 ; Humans ; Hypoxia ; Hypoxia-Inducible Factor 1, alpha Subunit ; Vascular Endothelial Growth Factor A/metabolism
Czasopismo naukowe
Tytuł :
[Effects of intermittent hypoxia stimulation with different frequencies on HT22 cell viability and expression of Hif-1α and p-NF-κB].
Autorzy :
Yang SC; Department of Physiology, Hebei University of Chinese Medicine, Shijiazhuang 050200, China.
Zhao Y; Department of Physiology, Hebei University of Chinese Medicine, Shijiazhuang 050200, China.
Zheng YY; Department of Physiology, Hebei University of Chinese Medicine, Shijiazhuang 050200, China.
Li WY; Department of Physiology, Hebei University of Chinese Medicine, Shijiazhuang 050200, China.
Zhao M; Department of Physiology, Hebei University of Chinese Medicine, Shijiazhuang 050200, China.
Ji ES; Department of Physiology, Hebei University of Chinese Medicine, Shijiazhuang 050200, China. .
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Źródło :
Sheng li xue bao : [Acta physiologica Sinica] [Sheng Li Xue Bao] 2021 Feb 25; Vol. 73 (1), pp. 26-34.
Typ publikacji :
Journal Article
MeSH Terms :
Hypoxia*
NF-kappa B*/metabolism
Animals ; Cell Hypoxia ; Cell Survival ; Hypoxia-Inducible Factor 1, alpha Subunit/genetics ; Mice ; Oxidative Stress ; Reactive Oxygen Species
Czasopismo naukowe
Tytuł :
Glioblastoma cell line shows phenotypes of cancer stem cells in hypoxic microenvironment of spheroids.
Autorzy :
Ohnishi K; Department of Biol, Ibaraki Prefectural University of Health Sciences, Japan. Electronic address: .
Tani T; National Institute of Radiological Sciences Hospital, Japan.
Tojo N; Department of Biol, Ibaraki Prefectural University of Health Sciences, Japan.
Sagara JI; Department of Biochem, Ibaraki Prefectural University of Health Sciences, Japan.
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2021 Mar 26; Vol. 546, pp. 150-154. Date of Electronic Publication: 2021 Feb 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Hypoxia*
Models, Biological*
Tumor Microenvironment*
Glioblastoma/*pathology
Neoplastic Stem Cells/*metabolism
Neoplastic Stem Cells/*pathology
Spheroids, Cellular/*metabolism
Spheroids, Cellular/*pathology
AC133 Antigen/metabolism ; Cell Culture Techniques ; Cell Line, Tumor ; Cell Movement ; Cell Survival/drug effects ; Cell Survival/radiation effects ; Flow Cytometry ; Genes, Reporter ; Humans ; Hydrogen-Ion Concentration ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; Neoplastic Stem Cells/drug effects ; Phenotype ; Spheroids, Cellular/drug effects ; Spheroids, Cellular/radiation effects ; Temozolomide/pharmacology ; X-Rays
Czasopismo naukowe
Tytuł :
An Oxygen-Concentration-Controllable Multiorgan Microfluidic Platform for Studying Hypoxia-Induced Lung Cancer-Liver Metastasis and Screening Drugs.
Autorzy :
Zheng L; University of Shanghai for Science and Technology, 516 Jungong Road, Shanghai 200093, China.
Wang B; University of Shanghai for Science and Technology, 516 Jungong Road, Shanghai 200093, China.
Sun Y; Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai 200032, China.
Dai B; University of Shanghai for Science and Technology, 516 Jungong Road, Shanghai 200093, China.
Fu Y; Department of Medical Microbiology and Parasitology, School of Basic Medical Sciences, Fudan University, 131 Dongan Road, Shanghai 200032, China.
Zhang Y; University of Shanghai for Science and Technology, 516 Jungong Road, Shanghai 200093, China.
Wang Y; University of Shanghai for Science and Technology, 516 Jungong Road, Shanghai 200093, China.
Yang Z; University of Shanghai for Science and Technology, 516 Jungong Road, Shanghai 200093, China.
Sun Z; East China Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, No. 300, Jungong Road, Shanghai 200090, China.
Zhuang S; University of Shanghai for Science and Technology, 516 Jungong Road, Shanghai 200093, China.
Zhang D; University of Shanghai for Science and Technology, 516 Jungong Road, Shanghai 200093, China.; Shanghai Institute of Intelligent Science and Technology, Tongji University, Shanghai 200092, China.
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Źródło :
ACS sensors [ACS Sens] 2021 Mar 26; Vol. 6 (3), pp. 823-832. Date of Electronic Publication: 2021 Mar 03.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Hypoxia*
Liver Neoplasms*
Lung Neoplasms*
Microfluidics*
A549 Cells ; Drug Screening Assays, Antitumor ; Early Detection of Cancer ; Humans ; Hypoxia-Inducible Factor 1, alpha Subunit/genetics ; Neoplasm Metastasis ; Oxygen ; Pharmaceutical Preparations
Czasopismo naukowe
Tytuł :
Neutrophil dynamics, plasticity and function in acute neurodegeneration following neonatal hypoxia-ischemia.
Autorzy :
Mülling K; Department of Pediatrics I, Neonatology & Experimental Perinatal Neurosciences, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
Fischer AJ; Department of Pediatrics I, Neonatology & Experimental Perinatal Neurosciences, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
Siakaeva E; Department of Otorhinolaryngology, Translational Oncology, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
Richter M; Department of Pediatrics I, Neonatology & Experimental Perinatal Neurosciences, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
Bordbari S; Department of Otorhinolaryngology, Translational Oncology, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
Spyra I; Department of Otorhinolaryngology, Translational Oncology, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
Köster C; Department of Pediatrics I, Neonatology & Experimental Perinatal Neurosciences, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
Hermann DM; Department of Neurology, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
Gunzer M; Institute for Experimental Immunology and Imaging, University Hospital Essen, University Duisburg-Essen, Essen, Germany; Leibniz-Institut für Analytische Wissenschaften-ISAS-e.V., Dortmund, Germany.
Felderhoff-Müser U; Department of Pediatrics I, Neonatology & Experimental Perinatal Neurosciences, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
Bendix I; Department of Pediatrics I, Neonatology & Experimental Perinatal Neurosciences, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
Jablonska J; Department of Otorhinolaryngology, Translational Oncology, University Hospital Essen, University Duisburg-Essen, Essen, Germany; German Cancer Consortium (DKTK) partner site Düsseldorf/Essen, Essen, Germany.
Herz J; Department of Pediatrics I, Neonatology & Experimental Perinatal Neurosciences, University Hospital Essen, University Duisburg-Essen, Essen, Germany. Electronic address: .
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Źródło :
Brain, behavior, and immunity [Brain Behav Immun] 2021 Feb; Vol. 92, pp. 234-244. Date of Electronic Publication: 2020 Dec 14.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Hypoxia-Ischemia, Brain*
Neutrophils*
Aged ; Animals ; Animals, Newborn ; Brain ; Child ; Humans ; Hypoxia ; Infant, Newborn ; Ischemia
Czasopismo naukowe
Tytuł :
Hypoxia preconditioning protects neuronal cells against traumatic brain injury through stimulation of glucose transport mediated by HIF-1α/GLUTs signaling pathway in rat.
Autorzy :
Wu X; Department of Neurosurgery, No. 901 Hospital of the Chinese People's Liberation Army Logistic Support Force, Hefei, Anhui, China.
Wang C; Department of Neurosurgery, No. 901 Hospital of the Chinese People's Liberation Army Logistic Support Force, Hefei, Anhui, China.
Wang J; Department of Neurosurgery, No. 901 Hospital of the Chinese People's Liberation Army Logistic Support Force, Hefei, Anhui, China.
Zhu M; Department of Neurosurgery, No. 901 Hospital of the Chinese People's Liberation Army Logistic Support Force, Hefei, Anhui, China.
Yao Y; Department of Neurosurgery, No. 901 Hospital of the Chinese People's Liberation Army Logistic Support Force, Hefei, Anhui, China.
Liu J; Department of Neurosurgery, No. 901 Hospital of the Chinese People's Liberation Army Logistic Support Force, Hefei, Anhui, China. .
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Źródło :
Neurosurgical review [Neurosurg Rev] 2021 Feb; Vol. 44 (1), pp. 411-422. Date of Electronic Publication: 2020 Jan 02.
Typ publikacji :
Journal Article
MeSH Terms :
Glucose Transport Proteins, Facilitative*
Hypoxia-Inducible Factor 1, alpha Subunit*
Signal Transduction*
Brain Injuries, Traumatic/*therapy
Ischemic Preconditioning/*methods
Neurons/*metabolism
Animals ; Antigens, Nuclear/metabolism ; Brain Injuries, Traumatic/complications ; Cell Survival ; Cerebral Cortex/metabolism ; Cerebral Cortex/pathology ; Energy Metabolism ; Glucose/metabolism ; Glucose Transporter Type 1/metabolism ; Glucose Transporter Type 3/metabolism ; Hypoxia ; Male ; Nerve Tissue Proteins/metabolism ; Nervous System Diseases/etiology ; Nervous System Diseases/physiopathology ; Neuroprotective Agents ; Rats ; Rats, Sprague-Dawley
Czasopismo naukowe
Tytuł :
Generation of biological hypotheses by functional imaging links tumor hypoxia to radiation induced tissue inflammation/glucose uptake in head and neck cancer.
Autorzy :
Zschaeck S; Department of Radiotherapy and Radiation Oncology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Germany; German Cancer Consortium (DKTK), Dresden, Germany, and German Cancer Research Center (DKFZ) Heidelberg, Germany; OncoRay, National Center for Radiation Research in Oncology, Medical Faculty and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden, Rossendorf, Germany; Charité Universitätsmedizin Berlin, Department of Radiation Oncology, Berlin, Germany; Berlin Institute of Health (BIH), Berlin, Germany. Electronic address: .
Zöphel K; German Cancer Consortium (DKTK), Dresden, Germany, and German Cancer Research Center (DKFZ) Heidelberg, Germany; OncoRay, National Center for Radiation Research in Oncology, Medical Faculty and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden, Rossendorf, Germany; Department of Nuclear Medicine, Medical Faculty and University Hospital Carl Gustav Carus, Dresden, Germany.
Seidlitz A; Department of Radiotherapy and Radiation Oncology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Germany; German Cancer Consortium (DKTK), Dresden, Germany, and German Cancer Research Center (DKFZ) Heidelberg, Germany; OncoRay, National Center for Radiation Research in Oncology, Medical Faculty and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden, Rossendorf, Germany.
Zips D; Department of Radiotherapy and Radiation Oncology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Germany; German Cancer Consortium (DKTK), Tübingen, Germany, and German Cancer Research Center (DKFZ) Heidelberg, Germany; Department of Radiation Oncology, University Hospital and Medical Faculty, Eberhard Karls University Tübingen, Germany.
Kotzerke J; German Cancer Consortium (DKTK), Dresden, Germany, and German Cancer Research Center (DKFZ) Heidelberg, Germany; OncoRay, National Center for Radiation Research in Oncology, Medical Faculty and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden, Rossendorf, Germany; Department of Nuclear Medicine, Medical Faculty and University Hospital Carl Gustav Carus, Dresden, Germany.
Baumann M; Department of Radiotherapy and Radiation Oncology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Germany; German Cancer Consortium (DKTK), Dresden, Germany, and German Cancer Research Center (DKFZ) Heidelberg, Germany; OncoRay, National Center for Radiation Research in Oncology, Medical Faculty and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden, Rossendorf, Germany; Helmholtz-Zentrum Dresden - Rossendorf, Institute of Radiooncology, Dresden, Germany; National Center for Tumour Diseases (NCT), Partner Site Dresden, Germany: German Cancer Research Center (DKFZ), Heidelberg, Germany, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany, and Helmholtz Association/Helmholtz-Zentrum Dresden, Rossendorf (HZDR), Dresden, Germany; German Cancer Research Center (DKFZ), Heidelberg, Germany.
Troost EGC; Department of Radiotherapy and Radiation Oncology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Germany; German Cancer Consortium (DKTK), Dresden, Germany, and German Cancer Research Center (DKFZ) Heidelberg, Germany; OncoRay, National Center for Radiation Research in Oncology, Medical Faculty and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden, Rossendorf, Germany; Helmholtz-Zentrum Dresden - Rossendorf, Institute of Radiooncology, Dresden, Germany; National Center for Tumour Diseases (NCT), Partner Site Dresden, Germany: German Cancer Research Center (DKFZ), Heidelberg, Germany, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany, and Helmholtz Association/Helmholtz-Zentrum Dresden, Rossendorf (HZDR), Dresden, Germany.
Löck S; Department of Radiotherapy and Radiation Oncology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Germany; German Cancer Consortium (DKTK), Dresden, Germany, and German Cancer Research Center (DKFZ) Heidelberg, Germany; OncoRay, National Center for Radiation Research in Oncology, Biostatistics and Modeling in Radiation Oncology group, Medical Faculty and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden, Rossendorf, Germany.
Krause M; Department of Radiotherapy and Radiation Oncology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Germany; German Cancer Consortium (DKTK), Dresden, Germany, and German Cancer Research Center (DKFZ) Heidelberg, Germany; OncoRay, National Center for Radiation Research in Oncology, Medical Faculty and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden, Rossendorf, Germany; Helmholtz-Zentrum Dresden - Rossendorf, Institute of Radiooncology, Dresden, Germany; National Center for Tumour Diseases (NCT), Partner Site Dresden, Germany: German Cancer Research Center (DKFZ), Heidelberg, Germany, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany, and Helmholtz Association/Helmholtz-Zentrum Dresden, Rossendorf (HZDR), Dresden, Germany.
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Źródło :
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology [Radiother Oncol] 2021 Feb; Vol. 155, pp. 204-211. Date of Electronic Publication: 2020 Oct 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Head and Neck Neoplasms*/diagnostic imaging
Head and Neck Neoplasms*/radiotherapy
Tumor Hypoxia*
Cell Hypoxia ; Fluorodeoxyglucose F18 ; Glucose ; Humans ; Inflammation/diagnostic imaging ; Misonidazole ; Positron-Emission Tomography ; Prospective Studies ; Radiopharmaceuticals
Czasopismo naukowe
Tytuł :
[Genotype and phenotype analysis of neonates with neonatal encephalopathy complicated with perinatal hypoxic event].
Autorzy :
Xiao TT; Department of Neonatology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai 201102, China.
Yang L; Center of Molecular Medicine, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai 201102, China.
Wu BB; Center of Molecular Medicine, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai 201102, China.
Peng XM; Center of Molecular Medicine, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai 201102, China.
Wang HJ; Center of Molecular Medicine, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai 201102, China.
Cheng GQ; Department of Neonatology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai 201102, China.
Wang LS; Department of Neonatology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai 201102, China.
Cao Y; Department of Neonatology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai 201102, China.
Hu LY; Department of Neonatology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai 201102, China.
Zhou WH; Department of Neonatology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai 201102, China.
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Źródło :
Zhonghua er ke za zhi = Chinese journal of pediatrics [Zhonghua Er Ke Za Zhi] 2021 Apr 02; Vol. 59 (4), pp. 280-285.
Typ publikacji :
Journal Article
MeSH Terms :
Cesarean Section*
Hypoxia-Ischemia, Brain*/genetics
3-Hydroxysteroid Dehydrogenases ; Child ; Female ; Genotype ; Humans ; Hypoxia ; Infant, Newborn ; Male ; Nerve Tissue Proteins ; Phenotype ; Potassium Channels, Sodium-Activated ; Pregnancy ; Retrospective Studies
Czasopismo naukowe
Tytuł :
Hypoxic preconditioning - A nonpharmacological approach in COVID-19 prevention.
Autorzy :
Hertzog RG; Military Medical Research Center, Bucharest, Romania.
Bicheru NS; Military Medical Research Center, Bucharest, Romania. Electronic address: .
Popescu DM; Military Medical Research Center, Bucharest, Romania.
Călborean O; Military Medical Research Center, Bucharest, Romania.
Catrina AM; Military Medical Research Center, Bucharest, Romania.
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Źródło :
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases [Int J Infect Dis] 2021 Feb; Vol. 103, pp. 415-419. Date of Electronic Publication: 2020 Nov 26.
Typ publikacji :
Journal Article
MeSH Terms :
Hypoxia*
COVID-19/*prevention & control
Animals ; Cell Survival ; Humans ; Hypoxia-Inducible Factor 1/metabolism ; Male ; Mesenchymal Stem Cells/metabolism ; SARS-CoV-2
Czasopismo naukowe
Tytuł :
Comment on: Serial blood cytokine and chemokine mRNA and microRNA over 48 h are insult specific in a piglet model of inflammation-sensitized hypoxia-ischaemia.
Autorzy :
Felderhoff-Müser U; Department of Paediatrics I, University Hospital Essen, University Duisburg-Essen, Hufelandstrasse 55, 45157, Essen, Germany. .
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Źródło :
Pediatric research [Pediatr Res] 2021 Feb; Vol. 89 (3), pp. 409-410. Date of Electronic Publication: 2020 Nov 17.
Typ publikacji :
Journal Article; Comment
MeSH Terms :
Hypoxia-Ischemia, Brain*
MicroRNAs*/genetics
Animals ; Chemokines ; Cytokines ; Hypoxia ; Inflammation ; Ischemia ; RNA, Messenger ; Swine
Czasopismo naukowe
Tytuł :
Altered Behavioral Performance in the Neuron-Specific HIF-1- and HIF-2-Deficient Mice Following Chronic Hypoxic Exposure.
Autorzy :
Ma L; Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH, USA.; School of Electronic Information Science and Technology, Nantong University, Nantong, Jiangsu Province, China.
Sebastian Garcia-Medina J; Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH, USA.
Ortet G; Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH, USA.
LaManna JC; Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH, USA.
Xu K; Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH, USA. .
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Źródło :
Advances in experimental medicine and biology [Adv Exp Med Biol] 2021; Vol. 1269, pp. 271-276.
Typ publikacji :
Journal Article
MeSH Terms :
Hypoxia*/genetics
Neurons*
Animals ; Basic Helix-Loop-Helix Transcription Factors ; Hypoxia-Inducible Factor 1 ; Hypoxia-Inducible Factor 1, alpha Subunit/genetics ; Mice ; Mice, Knockout ; Oxygen
Czasopismo naukowe
Tytuł :
LRP5 Regulates HIF-1α Stability via Interaction with PHD2 in Ischemic Myocardium.
Autorzy :
Ju S; Department of Biochemistry and Molecular Biology, Chosun University School of Medicine, Gwangju 61452, Korea.
Lim L; Cancer Mutation Research Center, Chosun University, Gwangju 61452, Korea.
Wi K; Department of Biochemistry and Molecular Biology, Chosun University School of Medicine, Gwangju 61452, Korea.
Park C; Department of Molecular & Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, LA 71103, USA.
Ki YJ; Department of Internal Medicine, Chosun University School of Medicine, Gwangju 61452, Korea.
Choi DH; Department of Internal Medicine, Chosun University School of Medicine, Gwangju 61452, Korea.
Song H; Department of Biochemistry and Molecular Biology, Chosun University School of Medicine, Gwangju 61452, Korea.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jun 19; Vol. 22 (12). Date of Electronic Publication: 2021 Jun 19.
Typ publikacji :
Journal Article
MeSH Terms :
Hypoxia-Inducible Factor 1, alpha Subunit/*metabolism
Hypoxia-Inducible Factor-Proline Dioxygenases/*metabolism
Low Density Lipoprotein Receptor-Related Protein-5/*metabolism
Myocardial Ischemia/*metabolism
Myocytes, Cardiac/*metabolism
Animals ; Animals, Newborn ; Gene Expression Regulation ; Hydroxylation ; Hypoxia/metabolism ; Low Density Lipoprotein Receptor-Related Protein-6/metabolism ; Primary Cell Culture ; Rats ; Wnt Signaling Pathway
Czasopismo naukowe
Tytuł :
Physiological hypoxia restrains the senescence-associated secretory phenotype via AMPK-mediated mTOR suppression.
Autorzy :
van Vliet T; European Research Institute for the Biology of Ageing (ERIBA), University Medical Center Groningen, Groningen, 9713 AV, the Netherlands.
Varela-Eirin M; European Research Institute for the Biology of Ageing (ERIBA), University Medical Center Groningen, Groningen, 9713 AV, the Netherlands.
Wang B; European Research Institute for the Biology of Ageing (ERIBA), University Medical Center Groningen, Groningen, 9713 AV, the Netherlands.
Borghesan M; European Research Institute for the Biology of Ageing (ERIBA), University Medical Center Groningen, Groningen, 9713 AV, the Netherlands.
Brandenburg SM; European Research Institute for the Biology of Ageing (ERIBA), University Medical Center Groningen, Groningen, 9713 AV, the Netherlands.
Franzin R; Experimental Nephrology Department, University Medical Center Groningen, University of Groningen, Groningen, 9713 GZ, the Netherlands.
Evangelou K; Molecular Carcinogenesis Group, Department of Histology and Embryology, Medical School, National and Kapodistrian University of Athens, Athens 157 72, Greece.
Seelen M; Experimental Nephrology Department, University Medical Center Groningen, University of Groningen, Groningen, 9713 GZ, the Netherlands.
Gorgoulis V; Molecular Carcinogenesis Group, Department of Histology and Embryology, Medical School, National and Kapodistrian University of Athens, Athens 157 72, Greece; Faculty Institute for Cancer Sciences, Manchester Academic Health Sciences Centre, University of Manchester, Manchester M13 9NQ, UK; Biomedical Research Foundation, Academy of Athens, Athens 115 27, Greece; Center for New Biotechnologies and Precision Medicine, Medical School, National and Kapodistrian University of Athens, Athens 157 72, Greece.
Demaria M; European Research Institute for the Biology of Ageing (ERIBA), University Medical Center Groningen, Groningen, 9713 AV, the Netherlands. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2021 May 06; Vol. 81 (9), pp. 2041-2052.e6. Date of Electronic Publication: 2021 Apr 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Proliferation*/drug effects
Cellular Senescence*/drug effects
AMP-Activated Protein Kinases/*metabolism
Hypoxia/*enzymology
TOR Serine-Threonine Kinases/*metabolism
Age Factors ; Animals ; Antibiotics, Antineoplastic/pharmacology ; Cell Hypoxia ; Cell Line, Tumor ; Doxorubicin/pharmacology ; Glycine/analogs & derivatives ; Glycine/pharmacology ; Humans ; Hydroxybenzoates/pharmacology ; Hypoxia/pathology ; Hypoxia/physiopathology ; Inflammation Mediators/metabolism ; Isoquinolines/pharmacology ; Mice, Inbred C57BL ; Muscle Strength ; NF-kappa B/metabolism ; Paracrine Communication ; Phenotype ; Signal Transduction
Czasopismo naukowe

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