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Tytuł :
[Changes of α-SMA, type I and type Ⅲ collagen in gingival tissue and expression of MMP-2 and TIMP-2 in gingival crevicular fluid under orthodontic force].
Autorzy :
Jiang LP; Department of Orthodontics, Affiliated Stomatological Hospital of Nanchang University, Jiangxi Provincial Key Laboratory of Oral Biomedicine. Nanchang 330006, Jiangxi Province, China. E-mail: .
Tang Z
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Źródło :
Shanghai kou qiang yi xue = Shanghai journal of stomatology [Shanghai Kou Qiang Yi Xue] 2021 Aug; Vol. 30 (4), pp. 402-405.
Typ publikacji :
Journal Article; Randomized Controlled Trial
MeSH Terms :
Matrix Metalloproteinase 2*
Tissue Inhibitor of Metalloproteinase-2*
Actins ; Collagen Type III ; Gingival Crevicular Fluid ; Humans ; Matrix Metalloproteinase 8 ; Tissue Inhibitor of Metalloproteinase-1
Czasopismo naukowe
Tytuł :
Biochemical and immunohistochemical analysis of tissue inhibitor of metalloproteinases-1 in human sound dentin.
Autorzy :
Gobbi P; Department of Biomolecular Sciences, Carlo Bo Urbino University, Via Aurelio Saffi 2, 61029, Urbino, Italy.
Maravic T; Department of Biomedical and Neuromotor Sciences, DIBINEM, University of Bologna - Alma Mater Studiorum, Via San Vitale 59, 40125, Bologna, Italy.
Comba A; Department of Biomedical and Neuromotor Sciences, DIBINEM, University of Bologna - Alma Mater Studiorum, Via San Vitale 59, 40125, Bologna, Italy.
Mazzitelli C; Department of Biomedical and Neuromotor Sciences, DIBINEM, University of Bologna - Alma Mater Studiorum, Via San Vitale 59, 40125, Bologna, Italy.
Mancuso E; Department of Biomedical and Neuromotor Sciences, DIBINEM, University of Bologna - Alma Mater Studiorum, Via San Vitale 59, 40125, Bologna, Italy.
Falconi M; Department of Biomedical and Neuromotor Sciences, DIBINEM, University of Bologna - Alma Mater Studiorum, Via San Vitale 59, 40125, Bologna, Italy.
Breschi L; Department of Biomedical and Neuromotor Sciences, DIBINEM, University of Bologna - Alma Mater Studiorum, Via San Vitale 59, 40125, Bologna, Italy. .
Mazzoni A; Department of Biomedical and Neuromotor Sciences, DIBINEM, University of Bologna - Alma Mater Studiorum, Via San Vitale 59, 40125, Bologna, Italy.
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Źródło :
Clinical oral investigations [Clin Oral Investig] 2021 Aug; Vol. 25 (8), pp. 5067-5075. Date of Electronic Publication: 2021 Feb 10.
Typ publikacji :
Journal Article
MeSH Terms :
Matrix Metalloproteinase 2*
Tissue Inhibitor of Metalloproteinase-1*
Dentin ; Humans ; Matrix Metalloproteinase 9 ; Matrix Metalloproteinases ; Tissue Inhibitor of Metalloproteinases
Czasopismo naukowe
Tytuł :
p21 produces a bioactive secretome that places stressed cells under immunosurveillance.
Autorzy :
Sturmlechner I; Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA.; Department of Pediatrics, Molecular Genetics Section, University of Groningen, University Medical Center Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, Netherlands.
Zhang C; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA.
Sine CC; Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA.
van Deursen EJ; Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA.
Jeganathan KB; Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA.
Hamada N; Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA.
Grasic J; Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA.
Friedman D; Department of Immunology, Mayo Clinic, Rochester, MN, USA.
Stutchman JT; Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA.
Can I; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA.
Hamada M; Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA.
Lim DY; Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA.
Lee JH; Epigenomics Program, Center for Individualized Medicine, Mayo Clinic, Rochester, MN, USA.
Ordog T; Epigenomics Program, Center for Individualized Medicine, Mayo Clinic, Rochester, MN, USA.; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.
Laberge RM; Unity Biotechnology, South San Francisco, CA 94080, USA.
Shapiro V; Department of Immunology, Mayo Clinic, Rochester, MN, USA.
Baker DJ; Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA.; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA.
Li H; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA.
van Deursen JM; Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA.; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA.
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Źródło :
Science (New York, N.Y.) [Science] 2021 Oct 29; Vol. 374 (6567), pp. eabb3420. Date of Electronic Publication: 2021 Oct 29.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Cellular Senescence*
Immunologic Surveillance*
Cyclin-Dependent Kinase Inhibitor p21/*metabolism
Animals ; Cell Cycle Checkpoints ; Cell Line ; Chemokines, CXC/metabolism ; Cyclin-Dependent Kinase Inhibitor p16/genetics ; Cyclin-Dependent Kinase Inhibitor p16/metabolism ; Cyclin-Dependent Kinase Inhibitor p21/genetics ; Genes, ras ; Hepatocytes/immunology ; Hepatocytes/metabolism ; Humans ; Macrophages/immunology ; Macrophages/metabolism ; Mice ; Mice, Transgenic ; Proto-Oncogene Proteins p21(ras)/metabolism ; Retinoblastoma Protein/metabolism ; Stress, Physiological ; T-Lymphocytes, Cytotoxic/immunology ; Transcription, Genetic
Czasopismo naukowe
Tytuł :
Novel chemotherapeutic agent FX-9 activates NF-κB signaling and induces G1 phase arrest by activating CDKN1A in a human prostate cancer cell line.
Autorzy :
Weiner F; Small Animal Clinic, University of Veterinary Medicine Hannover, 30559, Hannover, Germany.; Department of Medicine, Clinic III, Hematology, Oncology, Palliative Medicine, University of Rostock, 18057, Rostock, Germany.
Schille JT; Small Animal Clinic, University of Veterinary Medicine Hannover, 30559, Hannover, Germany.; Department of Medicine, Clinic III, Hematology, Oncology, Palliative Medicine, University of Rostock, 18057, Rostock, Germany.
Koczan D; Core Facility for Microarray Analysis, Institute for Immunology, University of Rostock, 18057, Rostock, Germany.
Wu XF; Leibniz Institute for Catalysis, 18059, Rostock, Germany.
Beller M; Leibniz Institute for Catalysis, 18059, Rostock, Germany.
Junghanss C; Department of Medicine, Clinic III, Hematology, Oncology, Palliative Medicine, University of Rostock, 18057, Rostock, Germany.
Hewicker-Trautwein M; Department of Pathology, University of Veterinary Medicine Hannover, 30559, Hannover, Germany.
Murua Escobar H; Department of Medicine, Clinic III, Hematology, Oncology, Palliative Medicine, University of Rostock, 18057, Rostock, Germany.; Comprehensive Cancer Center - Mecklenburg Vorpommern (CCC-MV), Campus Rostock, University of Rostock, 18057, Rostock, Germany.
Nolte I; Small Animal Clinic, University of Veterinary Medicine Hannover, 30559, Hannover, Germany. .
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Źródło :
BMC cancer [BMC Cancer] 2021 Oct 08; Vol. 21 (1), pp. 1088. Date of Electronic Publication: 2021 Oct 08.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents/*pharmacology
Cyclin-Dependent Kinase Inhibitor p21/*metabolism
G1 Phase Cell Cycle Checkpoints/*drug effects
NF-kappa B/*metabolism
Prostatic Neoplasms, Castration-Resistant/*metabolism
E2F1 Transcription Factor/antagonists & inhibitors ; G1 Phase Cell Cycle Checkpoints/genetics ; Gene Expression/drug effects ; Gene Expression Profiling/methods ; Humans ; Male ; Middle Aged ; PC-3 Cells ; Plasminogen Activator Inhibitor 1/metabolism ; Prostatic Neoplasms, Castration-Resistant/genetics ; S Phase Cell Cycle Checkpoints ; Time Factors ; Tissue Array Analysis
Czasopismo naukowe
Tytuł :
Progressive Cellular Senescence Mediates Renal Dysfunction in Ischemic Nephropathy.
Autorzy :
Kim SR; Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota.; Department of Nephrology and Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Korea.
Puranik AS; Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota.; Colton Center for Autoimmunity, Division of Rheumatology, New York University Langone Medical Center, New York, New York.
Jiang K; Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota.
Chen X; Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota.; Department of Nephrology, The Second Xiangya Hospital of Central South University, Changsha, China.
Zhu XY; Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota.
Taylor I; FlowJo, BD Life Sciences, Ashland, Oregon.
Khodadadi-Jamayran A; Applied Bioinformatics Laboratories, New York University School of Medicine, New York, New York.
Lerman A; Department of Cardiology, Mayo Clinic, Rochester, Minnesota.
Hickson LJ; Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota.
Childs BG; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota.
Textor SC; Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota.
Tchkonia T; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota.
Niewold TB; Colton Center for Autoimmunity, Division of Rheumatology, New York University Langone Medical Center, New York, New York.
Kirkland JL; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota.
Lerman LO; Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota .
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Źródło :
Journal of the American Society of Nephrology : JASN [J Am Soc Nephrol] 2021 Aug; Vol. 32 (8), pp. 1987-2004. Date of Electronic Publication: 2021 Jun 16.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Cellular Senescence/*physiology
Cyclin-Dependent Kinase Inhibitor p16/*metabolism
Ischemia/*physiopathology
Kidney/*physiopathology
Renal Insufficiency, Chronic/*physiopathology
p21-Activated Kinases/*metabolism
Animals ; Apoptosis/drug effects ; Caspase 8/metabolism ; Cellular Senescence/drug effects ; Cellular Senescence/genetics ; Chronic Disease ; Cyclin-Dependent Kinase Inhibitor p16/genetics ; Cyclin-Dependent Kinase Inhibitor p19/metabolism ; Cyclin-Dependent Kinase Inhibitor p21/genetics ; Dasatinib/pharmacology ; Disease Models, Animal ; Enzyme Activation/drug effects ; Epithelial Cells/physiology ; Epithelial-Mesenchymal Transition ; Gene Expression ; Heparin-binding EGF-like Growth Factor/genetics ; Humans ; Ischemia/etiology ; Kidney/blood supply ; Kidney/pathology ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Osteopontin/genetics ; Protein Kinase Inhibitors/pharmacology ; Renal Artery Obstruction/complications ; Renal Insufficiency, Chronic/etiology ; Renal Insufficiency, Chronic/pathology ; Sequence Analysis, RNA ; Single-Cell Analysis ; Tacrolimus/analogs & derivatives ; Tacrolimus/pharmacology ; Up-Regulation ; p21-Activated Kinases/genetics
Czasopismo naukowe
Tytuł :
Loss of dystrophin expression in skeletal muscle is associated with senescence of macrophages and endothelial cells.
Autorzy :
Young LV; Department of Applied Human Sciences, University of Prince Edward Island, Charlottetown, Prince Edward Island, Canada.
Morrison W; Department of Applied Human Sciences, University of Prince Edward Island, Charlottetown, Prince Edward Island, Canada.
Campbell C; Department of Applied Human Sciences, University of Prince Edward Island, Charlottetown, Prince Edward Island, Canada.
Moore EC; Department of Applied Human Sciences, University of Prince Edward Island, Charlottetown, Prince Edward Island, Canada.
Arsenault MG; Department of Applied Human Sciences, University of Prince Edward Island, Charlottetown, Prince Edward Island, Canada.
Dial AG; Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada.
Ng S; Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada.
Bellissimo CA; School of Kinesiology and Health Sciences, Muscle Health Research Centre, York University, Toronto, Ontario, Canada.
Perry CGR; School of Kinesiology and Health Sciences, Muscle Health Research Centre, York University, Toronto, Ontario, Canada.
Ljubicic V; Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada.
Johnston AP; Department of Applied Human Sciences, University of Prince Edward Island, Charlottetown, Prince Edward Island, Canada.; Department of Biomedical Sciences, University of Prince Edward Island, Charlottetown, Prince Edward Island, Canada.
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Źródło :
American journal of physiology. Cell physiology [Am J Physiol Cell Physiol] 2021 Jul 01; Vol. 321 (1), pp. C94-C103. Date of Electronic Publication: 2021 May 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cellular Senescence/*genetics
Cyclin-Dependent Kinase Inhibitor p21/*genetics
Endothelial Cells/*metabolism
Macrophages/*metabolism
Muscle, Skeletal/*metabolism
Muscular Dystrophy, Animal/*genetics
Animals ; Cyclin-Dependent Kinase Inhibitor p16/genetics ; Cyclin-Dependent Kinase Inhibitor p16/metabolism ; Cyclin-Dependent Kinase Inhibitor p21/metabolism ; Disease Models, Animal ; Dystrophin/deficiency ; Dystrophin/genetics ; Endothelial Cells/pathology ; Gene Expression Regulation ; Humans ; Macrophages/pathology ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Inbred mdx ; Muscle, Skeletal/pathology ; Muscular Dystrophy, Animal/metabolism ; Muscular Dystrophy, Animal/pathology ; Muscular Dystrophy, Duchenne/genetics ; Muscular Dystrophy, Duchenne/metabolism ; Muscular Dystrophy, Duchenne/pathology ; Myofibrils/metabolism ; Myofibrils/pathology ; Signal Transduction ; Tumor Suppressor Protein p53/genetics ; Tumor Suppressor Protein p53/metabolism ; beta-Galactosidase/genetics ; beta-Galactosidase/metabolism
Czasopismo naukowe
Tytuł :
Functional Analysis of p21 and Its Family Members in Trophoblastic Cells of the Placenta and Its Roles in Preeclampsia.
Autorzy :
Kreis NN; Obstetrics and Prenatal Medicine, Department of Gynecology and Obstetrics, University Hospital Frankfurt, J. W. Goethe-University Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany.
Friemel A; Obstetrics and Prenatal Medicine, Department of Gynecology and Obstetrics, University Hospital Frankfurt, J. W. Goethe-University Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany.
Jennewein L; Obstetrics and Prenatal Medicine, Department of Gynecology and Obstetrics, University Hospital Frankfurt, J. W. Goethe-University Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany.
Hoock SC; Obstetrics and Prenatal Medicine, Department of Gynecology and Obstetrics, University Hospital Frankfurt, J. W. Goethe-University Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany.
Hentrich AE; Obstetrics and Prenatal Medicine, Department of Gynecology and Obstetrics, University Hospital Frankfurt, J. W. Goethe-University Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany.
Nowak T; Medical Practice for Gynecology and Obstetrics, Mainzer Landstr. 265, 60326 Frankfurt, Germany.
Louwen F; Obstetrics and Prenatal Medicine, Department of Gynecology and Obstetrics, University Hospital Frankfurt, J. W. Goethe-University Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany.
Yuan J; Obstetrics and Prenatal Medicine, Department of Gynecology and Obstetrics, University Hospital Frankfurt, J. W. Goethe-University Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany.
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Źródło :
Cells [Cells] 2021 Aug 27; Vol. 10 (9). Date of Electronic Publication: 2021 Aug 27.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cyclin-Dependent Kinase Inhibitor p21/*metabolism
Placenta/*metabolism
Pre-Eclampsia/*metabolism
Trophoblasts/*metabolism
Adult ; Chorionic Gonadotropin/metabolism ; Cyclin-Dependent Kinase Inhibitor p27/metabolism ; Female ; Gene Expression/physiology ; Humans ; Placentation/physiology ; Pregnancy ; Pregnancy Trimester, First/metabolism
Czasopismo naukowe
Tytuł :
Expression of matrix metalloproteinases and their inhibitors at the implantation site in ampullary ectopic pregnancies.
Autorzy :
Gomez UT; Disciplina de Obstetricia, Departamento de Obstetricia e Ginecologia, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, Brazil.
Brizot ML; Disciplina de Obstetricia, Departamento de Obstetricia e Ginecologia, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, Brazil.
Pereira PP; Disciplina de Obstetricia, Departamento de Obstetricia e Ginecologia, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, Brazil.
Rodrigues AS; Disciplina de Obstetricia, Departamento de Obstetricia e Ginecologia, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, Brazil.
Schultz R; Departamento de Patologia, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, Brazil.
Hoshida MS; LIM 57 Laboratorio de Fisiologia Obstetrica, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil.
Francisco RPV; Disciplina de Obstetricia, Departamento de Obstetricia e Ginecologia, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, Brazil.
Cabar FR; Disciplina de Obstetricia, Departamento de Obstetricia e Ginecologia, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, Brazil. Electronic address: .
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Źródło :
Journal of gynecology obstetrics and human reproduction [J Gynecol Obstet Hum Reprod] 2021 May; Vol. 50 (5), pp. 102096. Date of Electronic Publication: 2021 Feb 13.
Typ publikacji :
Journal Article
MeSH Terms :
Matrix Metalloproteinases/*metabolism
Pregnancy, Tubal/*metabolism
Tissue Inhibitor of Metalloproteinases/*metabolism
Trophoblasts/*metabolism
Adult ; Biomarkers/metabolism ; Female ; Humans ; Matrix Metalloproteinase 14/metabolism ; Matrix Metalloproteinase 2/metabolism ; Matrix Metalloproteinase 9/metabolism ; Pregnancy ; Pregnancy, Tubal/enzymology ; Pregnancy, Tubal/pathology ; Pregnancy, Tubal/surgery ; Prospective Studies ; Salpingectomy ; Tissue Inhibitor of Metalloproteinase-1/metabolism ; Tissue Inhibitor of Metalloproteinase-2/metabolism ; Tissue Inhibitor of Metalloproteinase-3/metabolism ; Trophoblasts/pathology
Czasopismo naukowe
Tytuł :
Deficiency of plasminogen activator inhibitor-2 results in accelerated tumor growth.
Autorzy :
Westrick RJ; Department of Biological Sciences, Oakland University, Rochester, Michigan.; Department of Bioengineering, Oakland University, Rochester, Michigan.; Centers for Data Science and Big Data Analytics and Biomedical Research, Oakland University, Rochester, Michigan.
Røjkjaer LP; Life Sciences Institute, University of Michigan, Ann Arbor, Michigan.
Yang AY; Life Sciences Institute, University of Michigan, Ann Arbor, Michigan.
Roh MH; Department of Pathology, University of Michigan, Ann Arbor, Michigan.
Siebert AE; Department of Biological Sciences, Oakland University, Rochester, Michigan.
Ginsburg D; Life Sciences Institute, University of Michigan, Ann Arbor, Michigan.; Howard Hughes Medical Institute, University of Michigan, Ann Arbor, Michigan.; Departments of Human Genetics, Internal Medicine and Pediatrics, University of Michigan, Ann Arbor, Michigan.
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Źródło :
Journal of thrombosis and haemostasis : JTH [J Thromb Haemost] 2020 Nov; Vol. 18 (11), pp. 2968-2975. Date of Electronic Publication: 2020 Oct 01.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Plasminogen Activator Inhibitor 2*/genetics
Serpins*/genetics
Animals ; Mice ; Mice, Inbred C57BL ; Neoplasm Invasiveness ; Plasminogen Activator Inhibitor 1 ; Urokinase-Type Plasminogen Activator
Czasopismo naukowe
Tytuł :
Effect of hTIMP-1 overexpression in human umbilical cord mesenchymal stem cells on the repair of pancreatic islets in type-1 diabetic mice.
Autorzy :
Bao Y; Department of Nephrology, National Clinical Research Center for Child Health, The Children's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Zhao Z; Clinic of Division of Child Health Care, National Clinical Research Center for Child Health, The Children's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Gao H; Department of Pediatric and Adolescent Gynaecology, National Clinical Research Center for Child Health, The Children's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
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Źródło :
Cell biology international [Cell Biol Int] 2021 May; Vol. 45 (5), pp. 1038-1049. Date of Electronic Publication: 2021 Feb 04.
Typ publikacji :
Journal Article
MeSH Terms :
Islets of Langerhans/*metabolism
Tissue Inhibitor of Metalloproteinase-1/*genetics
Animals ; Diabetes Mellitus, Experimental/metabolism ; Diabetes Mellitus, Type 1/metabolism ; Diabetes Mellitus, Type 1/therapy ; Disease Models, Animal ; Fetal Blood/metabolism ; Glucose/metabolism ; Human Embryonic Stem Cells/metabolism ; Humans ; Insulin/metabolism ; Insulin Secretion ; Islets of Langerhans/cytology ; Islets of Langerhans Transplantation/methods ; Male ; Mesenchymal Stem Cell Transplantation/methods ; Mesenchymal Stem Cells/metabolism ; Mesenchymal Stem Cells/physiology ; Mice ; Mice, Inbred BALB C ; Streptozocin/pharmacology ; Tissue Inhibitor of Metalloproteinase-1/metabolism ; Tissue Inhibitor of Metalloproteinases/genetics ; Tissue Inhibitor of Metalloproteinases/metabolism ; Umbilical Cord/cytology
Czasopismo naukowe
Tytuł :
Dominant role of CDKN2B/p15INK4B of 9p21.3 tumor suppressor hub in inhibition of cell-cycle and glycolysis.
Autorzy :
Xia Y; Department of Urology, New York University School of Medicine, New York, NY, USA.
Liu Y; Department of Urology, New York University School of Medicine, New York, NY, USA.
Yang C; Department of Chemistry, New York University, New York, NY, USA.
Simeone DM; Department of Surgery, New York University School of Medicine, New York, NY, USA.; Department of Pathology, New York University School of Medicine, New York, NY, USA.
Sun TT; Department of Cell Biology, New York University School of Medicine, New York, NY, USA.
DeGraff DJ; Department of Pathology and Laboratory Medicine and Department of Surgery, Division of Urology, The Pennsylvania State University College of Medicine, Hershey, PA, USA.
Tang MS; Department of Environmental Medicine, New York University School of Medicine, New York, NY, USA.
Zhang Y; Department of Chemistry, New York University, New York, NY, USA.
Wu XR; Department of Urology, New York University School of Medicine, New York, NY, USA. .; Department of Pathology, New York University School of Medicine, New York, NY, USA. .; Veterans Affairs New York Harbor Healthcare System, New York, NY, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Apr 06; Vol. 12 (1), pp. 2047. Date of Electronic Publication: 2021 Apr 06.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Cell Cycle*
Glycolysis*
Chromosomes, Mammalian/*genetics
Cyclin-Dependent Kinase Inhibitor p15/*metabolism
Aerobiosis ; Amino Acid Sequence ; Animals ; Binding, Competitive ; Breeding ; Carcinogenesis/metabolism ; Carcinogenesis/pathology ; Cell Line, Tumor ; Cell Proliferation ; Crosses, Genetic ; Cyclin-Dependent Kinase Inhibitor p15/chemistry ; Cyclin-Dependent Kinase Inhibitor p16/metabolism ; Cyclin-Dependent Kinases/metabolism ; Down-Regulation ; Female ; Humans ; Hydrogen Bonding ; Male ; Mice, Transgenic ; Models, Molecular ; Oncogenes ; Penetrance ; Phosphopyruvate Hydratase/metabolism ; Protein Domains ; Proto-Oncogene Proteins p21(ras) ; Structural Homology, Protein ; Urinary Bladder Neoplasms/pathology ; Urothelium/metabolism
Czasopismo naukowe
Tytuł :
Clinical CDK4/6 inhibitors induce selective and immediate dissociation of p21 from cyclin D-CDK4 to inhibit CDK2.
Autorzy :
Pack LR; Department of Chemical and Systems Biology, Stanford University, Stanford, CA, USA.
Daigh LH; Department of Chemical and Systems Biology, Stanford University, Stanford, CA, USA.
Chung M; Department of Chemical and Systems Biology, Stanford University, Stanford, CA, USA.
Meyer T; Department of Chemical and Systems Biology, Stanford University, Stanford, CA, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Jun 07; Vol. 12 (1), pp. 3356. Date of Electronic Publication: 2021 Jun 07.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Cyclin D/*metabolism
Cyclin-Dependent Kinase 2/*antagonists & inhibitors
Cyclin-Dependent Kinase 4/*antagonists & inhibitors
Cyclin-Dependent Kinase 6/*antagonists & inhibitors
Cyclin-Dependent Kinase Inhibitor p21/*metabolism
Protein Kinase Inhibitors/*pharmacology
Animals ; Cell Cycle/drug effects ; Cell Line ; Cell Nucleus/drug effects ; Cell Nucleus/metabolism ; Cyclin-Dependent Kinase 2/genetics ; Cyclin-Dependent Kinase 2/metabolism ; Cyclin-Dependent Kinase 4/genetics ; Cyclin-Dependent Kinase 4/metabolism ; Cyclin-Dependent Kinase 6/genetics ; Cyclin-Dependent Kinase 6/metabolism ; Cyclin-Dependent Kinase Inhibitor p27/metabolism ; Epithelial Cells/drug effects ; Epithelial Cells/metabolism ; Humans ; MCF-7 Cells ; Mice ; Microscopy, Fluorescence ; Piperazines/pharmacology ; Protein Binding ; Pyridines/pharmacology ; Retinal Pigment Epithelium/cytology ; Retinal Pigment Epithelium/drug effects ; Retinal Pigment Epithelium/metabolism
Czasopismo naukowe
Tytuł :
Targeted inactivation of soybean proteinase inhibitors using zinc.
Autorzy :
Rehder A; Department of Food Science, Faculty of Science, University of Copenhagen, Rolighedsvej 26, 1958 Frederiksberg C, Denmark.
Sørensen JC; Department of Food Science, Faculty of Science, University of Copenhagen, Rolighedsvej 26, 1958 Frederiksberg C, Denmark.
Markedal KE; Department of Food Science, Faculty of Science, University of Copenhagen, Rolighedsvej 26, 1958 Frederiksberg C, Denmark.
Sørensen H; Department of Food Science, Faculty of Science, University of Copenhagen, Rolighedsvej 26, 1958 Frederiksberg C, Denmark.
Sørensen S; Department of Food Science, Faculty of Science, University of Copenhagen, Rolighedsvej 26, 1958 Frederiksberg C, Denmark.
Petersen IL; Department of Food Science, Faculty of Science, University of Copenhagen, Rolighedsvej 26, 1958 Frederiksberg C, Denmark. Electronic address: .
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Źródło :
Food chemistry [Food Chem] 2021 Jul 01; Vol. 349, pp. 129049. Date of Electronic Publication: 2021 Jan 12.
Typ publikacji :
Journal Article
MeSH Terms :
Trypsin Inhibitor, Bowman-Birk Soybean/*metabolism
Trypsin Inhibitor, Kunitz Soybean/*metabolism
Zinc/*pharmacology
Disulfides/chemistry ; Enzyme Activation/drug effects ; Trypsin Inhibitor, Bowman-Birk Soybean/chemistry ; Trypsin Inhibitor, Kunitz Soybean/chemistry
Czasopismo naukowe
Tytuł :
Comprehensive analysis of expression, prognosis and immune infiltration for TIMPs in glioblastoma.
Autorzy :
Han J; Department of Neurosurgery, the Affiliated Hospital of Qingdao University, Qingdao, China.
Jing Y; Department of Neurosurgery, the Affiliated Hospital of Qingdao University, Qingdao, China.
Han F; Department of Neurosurgery, the Affiliated Hospital of Qingdao University, Qingdao, China.
Sun P; Department of Neurosurgery, the Affiliated Hospital of Qingdao University, Qingdao, China. .
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Źródło :
BMC neurology [BMC Neurol] 2021 Nov 15; Vol. 21 (1), pp. 447. Date of Electronic Publication: 2021 Nov 15.
Typ publikacji :
Journal Article
MeSH Terms :
Glioblastoma*
Tissue Inhibitor of Metalloproteinases*/genetics
Tissue Inhibitor of Metalloproteinases*/metabolism
CD4-Positive T-Lymphocytes ; CD8-Positive T-Lymphocytes ; Humans ; Matrix Metalloproteinases ; Prognosis
Czasopismo naukowe
Tytuł :
Up-regulated DNA-binding inhibitor Id3 promotes differentiation of regulatory T cell to influence antiviral immunity in chronic hepatitis B virus infection.
Autorzy :
Liu C; Department of Clinical Laboratory, Peking University People's Hospital, Beijing, China.
Zeng X; Department of Clinical Laboratory, Peking University People's Hospital, Beijing, China.
Yu S; Department of Immunology, School of Basic Medical Sciences, Peking University, NHC Key Laboratory of Medical Immunology (Peking University), Beijing, China.
Ren L; Department of Immunology, School of Basic Medical Sciences, Peking University, NHC Key Laboratory of Medical Immunology (Peking University), Beijing, China.
Sun X; Department of Immunology, School of Basic Medical Sciences, Peking University, NHC Key Laboratory of Medical Immunology (Peking University), Beijing, China.
Long Y; Department of Clinical Laboratory, Peking University People's Hospital, Beijing, China.
Wang X; Department of Biotechnology, Beijing Institute of Radiation Medicine, Beijing, China.
Lu S; Department of Clinical Laboratory, Peking University People's Hospital, Beijing, China.
Song Y; Department of Clinical Laboratory, Peking University People's Hospital, Beijing, China.
Sun XH; Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, United States.
Zhang Y; Department of Immunology, School of Basic Medical Sciences, Peking University, NHC Key Laboratory of Medical Immunology (Peking University), Beijing, China; Institute of Biological Sciences, Jinzhou Medical University, Jinzhou, Liaoning, China. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Nov 15; Vol. 285, pp. 119991. Date of Electronic Publication: 2021 Sep 28.
Typ publikacji :
Journal Article
MeSH Terms :
Hepatitis B virus/*immunology
Hepatitis B, Chronic/*immunology
Inhibitor of Differentiation Proteins/*metabolism
Neoplasm Proteins/*metabolism
T-Lymphocytes, Regulatory/*immunology
Adult ; Animals ; Cell Differentiation ; Female ; Gene Expression Regulation ; Humans ; Inhibitor of Differentiation Proteins/genetics ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Middle Aged ; Neoplasm Proteins/genetics ; RNA-Seq ; Up-Regulation
Czasopismo naukowe
Tytuł :
C1 esterase inhibitor for angiotensin-converting enzyme inhibitor-induced angioedema at a community teaching health system: A brief retrospective propensity-matched cohort study.
Autorzy :
Mohorn PL; Department of Pharmacy, Northeast Georgia Health System, Gainesville, GA, USA. Electronic address: .
Roebuck LD; Department of Pharmacy, Northeast Georgia Health System, Gainesville, GA, USA.
Raybon-Rojas E; Division of Critical Care and Pulmonology, Northeast Georgia Health System, Gainesville, GA, USA.
Duncan C; Georgia Emergency Department Services, Department of Emergency Medicine, Northeast Georgia Health System, Gainesville, GA, USA.
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Źródło :
The American journal of emergency medicine [Am J Emerg Med] 2021 Nov; Vol. 49, pp. 6-9. Date of Electronic Publication: 2021 May 17.
Typ publikacji :
Journal Article
MeSH Terms :
Angioedema/*etiology
Angiotensin-Converting Enzyme Inhibitors/*adverse effects
Complement C1 Inhibitor Protein/*pharmacology
Aged ; Angioedema/physiopathology ; Angiotensin-Converting Enzyme Inhibitors/therapeutic use ; Cohort Studies ; Complement C1 Inhibitor Protein/therapeutic use ; Female ; Humans ; Male ; Middle Aged ; Propensity Score ; Prospective Studies ; Retrospective Studies
Czasopismo naukowe
Tytuł :
Quantile-specific heritability of plasminogen activator inhibitor type-1 (PAI-1, aka SERPINE1) and other hemostatic factors.
Autorzy :
Williams PT; Lawrence Berkeley National Laboratory, Molecular Biophysics & Integrated Bioimaging Division, Berkeley, CA, USA.
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Źródło :
Journal of thrombosis and haemostasis : JTH [J Thromb Haemost] 2021 Oct; Vol. 19 (10), pp. 2559-2571. Date of Electronic Publication: 2021 Aug 08.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Hemostatics*
Plasminogen Activator Inhibitor 1*/genetics
Alleles ; Fibrinolysis ; Genotype ; Humans
Czasopismo naukowe
Tytuł :
microRNA-10b promotes the apoptosis of bovine ovarian granulosa cells by targeting plasminogen activator inhibitor-1.
Autorzy :
Guo L; Key Lab of Animal Production, Product Quality and Security, Ministry of Education, Jilin Agricultural University, Jilin, Changchun, 130118, China; College of Animal Science and Technology, Jilin Agricultural University, Changchun, 130118, China.
Huang Q; Key Lab of Animal Production, Product Quality and Security, Ministry of Education, Jilin Agricultural University, Jilin, Changchun, 130118, China; College of Animal Science and Technology, Jilin Agricultural University, Changchun, 130118, China.
Zhao J; Key Lab of Animal Production, Product Quality and Security, Ministry of Education, Jilin Agricultural University, Jilin, Changchun, 130118, China; College of Animal Science and Technology, Jilin Agricultural University, Changchun, 130118, China.
Liu H; Key Lab of Animal Production, Product Quality and Security, Ministry of Education, Jilin Agricultural University, Jilin, Changchun, 130118, China; College of Animal Science and Technology, Jilin Agricultural University, Changchun, 130118, China.
Lu W; Key Lab of Animal Production, Product Quality and Security, Ministry of Education, Jilin Agricultural University, Jilin, Changchun, 130118, China; College of Animal Science and Technology, Jilin Agricultural University, Changchun, 130118, China. Electronic address: .
Wang J; Key Lab of Animal Production, Product Quality and Security, Ministry of Education, Jilin Agricultural University, Jilin, Changchun, 130118, China; College of Animal Science and Technology, Jilin Agricultural University, Changchun, 130118, China. Electronic address: .
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Źródło :
Theriogenology [Theriogenology] 2021 Dec; Vol. 176, pp. 206-216. Date of Electronic Publication: 2021 Oct 04.
Typ publikacji :
Journal Article
MeSH Terms :
MicroRNAs*/genetics
Phosphatidylinositol 3-Kinases*
Plasminogen Activator Inhibitor 1*/genetics
Animals ; Apoptosis ; Cattle ; Cell Proliferation ; Female ; Follicular Atresia ; Granulosa Cells ; Proto-Oncogene Proteins c-akt
Czasopismo naukowe
Tytuł :
Assessment of prognostic value of tissue inhibitors of metalloproteinase 3 (TIMP3) protein in ovarian cancer.
Autorzy :
Hakamy S; Center of Excellence in Genomic Medicine Research, King Abdulaziz University, Jeddah, Saudi Arabia.; Medical Technology Department, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia.
Assidi M; Center of Excellence in Genomic Medicine Research, King Abdulaziz University, Jeddah, Saudi Arabia.; Medical Technology Department, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia.
Jafri MA; Center of Excellence in Genomic Medicine Research, King Abdulaziz University, Jeddah, Saudi Arabia.; Medical Technology Department, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia.
Nedjadi T; King Abdullah International Medical Research Center, King Saud Bin Abdulaziz University for Health Sciences. Ministry of National Guard-Health Affairs, Jeddah, Saudi Arabia.
Alkhatabi H; Center of Excellence in Genomic Medicine Research, King Abdulaziz University, Jeddah, Saudi Arabia.; Medical Technology Department, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia.
Al-Qahtani A; Center of Excellence in Genomic Medicine Research, King Abdulaziz University, Jeddah, Saudi Arabia.
Al-Maghrabi J; Department of Pathology, Faculty of Medicine, King Abdulaziz University Hospital, Jeddah, Saudi Arabia.
Sait K; Department of Obstetrics and Gynecology, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
Al-Qahtani M; Center of Excellence in Genomic Medicine Research, King Abdulaziz University, Jeddah, Saudi Arabia.
Buhmeida A; Center of Excellence in Genomic Medicine Research, King Abdulaziz University, Jeddah, Saudi Arabia.
Chaudhary A; Medical Technology Department, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia.; Center of Innovation in Personalized Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
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Źródło :
The Libyan journal of medicine [Libyan J Med] 2021 Dec; Vol. 16 (1), pp. 1937866.
Typ publikacji :
Journal Article
MeSH Terms :
Ovarian Neoplasms*
Tissue Inhibitor of Metalloproteinase-3*
Female ; Humans ; Kaplan-Meier Estimate ; Metalloproteases ; Prognosis
Czasopismo naukowe
Tytuł :
The value of urine cell cycle arrest biomarkers to predict persistent acute kidney injury: A systematic review and meta-analysis.
Autorzy :
Jiang W
Yu J
Wang H
Zheng R
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Źródło :
Clinical nephrology [Clin Nephrol] 2021 Dec; Vol. 96 (6), pp. 327-336.
Typ publikacji :
Journal Article; Meta-Analysis; Systematic Review
MeSH Terms :
Acute Kidney Injury*/diagnosis
Acute Kidney Injury*/etiology
Tissue Inhibitor of Metalloproteinase-2*
Biomarkers ; Cell Cycle Checkpoints ; Humans ; ROC Curve
Czasopismo naukowe

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