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Tytuł :
The interplay among oxidative stress, brain insulin resistance and AMPK dysfunction contribute to neurodegeneration in type 2 diabetes and Alzheimer disease.
Autorzy :
Barone E; Department of Biochemical Sciences 'A. Rossi-Fanelli', Sapienza University of Rome, Piazzale A. Moro 5, 00185, Roma, Italy.
Di Domenico F; Department of Biochemical Sciences 'A. Rossi-Fanelli', Sapienza University of Rome, Piazzale A. Moro 5, 00185, Roma, Italy.
Perluigi M; Department of Biochemical Sciences 'A. Rossi-Fanelli', Sapienza University of Rome, Piazzale A. Moro 5, 00185, Roma, Italy.
Butterfield DA; Department of Chemistry and Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, 40506-0055, USA. Electronic address: .
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Źródło :
Free radical biology & medicine [Free Radic Biol Med] 2021 Nov 20; Vol. 176, pp. 16-33. Date of Electronic Publication: 2021 Sep 14.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Review
MeSH Terms :
Alzheimer Disease*
Diabetes Mellitus, Type 2*/complications
Insulin Resistance*
AMP-Activated Protein Kinases/genetics ; Aged ; Brain ; Humans ; Oxidative Stress
Czasopismo naukowe
Tytuł :
Independent associations of thyroid-related hormones with hepatic steatosis and insulin resistance in euthyroid overweight/obese Chinese adults.
Autorzy :
Ma D; School of Medicine, Xiamen University, Xiamen, China.
Zeng J; Department of Endocrinology and Diabetes, The First Affiliated Hospital, Xiamen University, Xiamen, China.; Xiamen Clinical Medical Center for Endocrine and Metabolic Diseases, Xiamen, China.
Huang B; Department of Endocrinology and Diabetes, The First Affiliated Hospital, Xiamen University, Xiamen, China.; Xiamen Clinical Medical Center for Endocrine and Metabolic Diseases, Xiamen, China.
Yan F; Department of Endocrinology and Diabetes, The First Affiliated Hospital, Xiamen University, Xiamen, China.; Xiamen Clinical Medical Center for Endocrine and Metabolic Diseases, Xiamen, China.
Ye J; The Third Clinical Medical College, Fujian Medical University, Fuzhou, China.
Chen Y; The Third Clinical Medical College, Fujian Medical University, Fuzhou, China.
Zeng X; The Third Clinical Medical College, Fujian Medical University, Fuzhou, China.
Zheng X; Department of Endocrinology and Diabetes, The First Affiliated Hospital, Xiamen University, Xiamen, China.; Xiamen Clinical Medical Center for Endocrine and Metabolic Diseases, Xiamen, China.
Xiao F; Department of Endocrinology and Diabetes, The First Affiliated Hospital, Xiamen University, Xiamen, China.; Xiamen Clinical Medical Center for Endocrine and Metabolic Diseases, Xiamen, China.
Lin M; Department of Endocrinology and Diabetes, The First Affiliated Hospital, Xiamen University, Xiamen, China.; Xiamen Clinical Medical Center for Endocrine and Metabolic Diseases, Xiamen, China.
Liu C; Department of Endocrinology and Diabetes, The First Affiliated Hospital, Xiamen University, Xiamen, China. .; Xiamen Clinical Medical Center for Endocrine and Metabolic Diseases, Xiamen, China. .; Fujian Province Key Laboratory of Diabetes Translational Medicine, Xiamen, China. .
Li Z; Epidemiology Research Unit, Translational Medical Research Center, The First Affiliated Hospital, Xiamen University, Xiamen, China. .
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Źródło :
BMC gastroenterology [BMC Gastroenterol] 2021 Nov 18; Vol. 21 (1), pp. 431. Date of Electronic Publication: 2021 Nov 18.
Typ publikacji :
Journal Article
MeSH Terms :
Fatty Liver*
Insulin Resistance*
Adult ; China ; Cross-Sectional Studies ; Humans ; Obesity/complications ; Overweight/complications ; Thyroid Gland ; Thyroid Hormones ; Thyrotropin ; Thyroxine ; Triiodothyronine
Czasopismo naukowe
Tytuł :
Programmed cell death 5 improves skeletal muscle insulin resistance by inhibiting IRS-1 ubiquitination through stabilization of MDM2.
Autorzy :
Li B; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, P.R. China.
Ye J; Trauma Medicine Center, Peking University People's Hospital; Key Laboratory of Trauma and Neural Regeneration (Peking University), National Center for Trauma Medicine, Beijing 100044, P.R. China; Department of Central Laboratory & Institute of Clinical Molecular Biology, Peking University People's Hospital, Beijing 100044, P.R. China.
Liu R; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, P.R. China.
Weng L; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, P.R. China.
Cao Y; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, P.R. China.
Jia S; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, P.R. China.
Xu C; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, P.R. China.
Liu Y; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, P.R. China.
Yan S; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, P.R. China.
Zheng M; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, P.R. China. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Nov 15; Vol. 285, pp. 119918. Date of Electronic Publication: 2021 Sep 01.
Typ publikacji :
Journal Article
MeSH Terms :
Insulin Resistance*
Ubiquitination*
Apoptosis Regulatory Proteins/*physiology
Insulin Receptor Substrate Proteins/*metabolism
Neoplasm Proteins/*physiology
Proto-Oncogene Proteins c-mdm2/*metabolism
Animals ; Apoptosis Regulatory Proteins/genetics ; Cell Differentiation ; Cell Line ; Diet, High-Fat ; Disease Models, Animal ; Enzyme Stability ; Gene Knockdown Techniques ; Male ; Mice ; Mice, Inbred C57BL ; Muscle Fibers, Skeletal/cytology ; Myoblasts/cytology ; Myoblasts/drug effects ; Neoplasm Proteins/genetics ; Obesity/genetics ; Obesity/metabolism ; Palmitates/pharmacology ; Proteolysis/drug effects
Czasopismo naukowe
Tytuł :
Efficacy of Bushen Huatan Decoction combined with Baduanjin in the treatment of polycystic ovary syndrome with insulin resistance (IR-PCOS), kidney deficiency and phlegm dampness: study protocol for a randomized controlled trial.
Autorzy :
Qian H; Department of Reproduction, Zhangjiagang TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Zhangjiagang, Suzhou, Jiangsu, China.
Xu W; Department of Reproduction, Zhangjiagang TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Zhangjiagang, Suzhou, Jiangsu, China.
Cui L; Department of Pathology, Zhangjiagang TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Zhangjiagang, Suzhou, Jiangsu, China.
Wang R; Department of Laboratory Medicine, Zhangjiagang TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Zhangjiagang, Suzhou, Jiangsu, China.
Wang J; Department of Reproduction, Zhangjiagang TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Zhangjiagang, Suzhou, Jiangsu, China.
Tang M; Department of Reproduction, Zhangjiagang TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Zhangjiagang, Suzhou, Jiangsu, China.
Wei M; The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China. .
Wang L; Department of Reproduction, Zhangjiagang TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Zhangjiagang, Suzhou, Jiangsu, China. .
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Źródło :
Trials [Trials] 2021 Nov 07; Vol. 22 (1), pp. 781. Date of Electronic Publication: 2021 Nov 07.
Typ publikacji :
Clinical Trial Protocol; Journal Article
MeSH Terms :
Insulin Resistance*
Metabolic Syndrome*
Metformin*
Polycystic Ovary Syndrome*/diagnosis
Polycystic Ovary Syndrome*/drug therapy
Female ; Humans ; Insulin ; Kidney ; Pregnancy ; Randomized Controlled Trials as Topic
Czasopismo naukowe
Tytuł :
PPAR-γ-induced changes in visceral fat and adiponectin levels are associated with improvement of steatohepatitis in patients with NASH.
Autorzy :
Gastaldelli A; Diabetes Division, The University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.; Institute of Clinical Physiology, National Research Council, CNR, Pisa, Italy.
Sabatini S; Institute of Clinical Physiology, National Research Council, CNR, Pisa, Italy.; Università degli Studi di Siena, Siena, Italy.
Carli F; Institute of Clinical Physiology, National Research Council, CNR, Pisa, Italy.
Gaggini M; Institute of Clinical Physiology, National Research Council, CNR, Pisa, Italy.
Bril F; Division of Endocrinology, Diabetes and Metabolism, University of Florida, Gainesville, FL, USA.
Belfort-DeAguiar R; Department of Internal Medicine and Endocrinology, Yale University School of Medicine, New Haven, CT, USA.
Positano V; Fondazione Toscana Gabriele Monasterio, Pisa, Italy.
Barb D; Division of Endocrinology, Diabetes and Metabolism, University of Florida, Gainesville, FL, USA.
Kadiyala S; Division of Endocrinology, Diabetes and Metabolism, University of Florida, Gainesville, FL, USA.; Division of Endocrinology, Diabetes and Metabolism, Malcom Randall Veteran Administration Medical Center at Gainesville, Gainesville, FL, USA.
Harrison S; Pinnacle Clinical Research Group, San Antonio, TX, USA.
Cusi K; Division of Endocrinology, Diabetes and Metabolism, University of Florida, Gainesville, FL, USA.; Division of Endocrinology, Diabetes and Metabolism, Malcom Randall Veteran Administration Medical Center at Gainesville, Gainesville, FL, USA.
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Źródło :
Liver international : official journal of the International Association for the Study of the Liver [Liver Int] 2021 Nov; Vol. 41 (11), pp. 2659-2670. Date of Electronic Publication: 2021 Jul 21.
Typ publikacji :
Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms :
Insulin Resistance*
Non-alcoholic Fatty Liver Disease*/drug therapy
Thiazolidinediones*/therapeutic use
Adiponectin ; Diet, Reducing ; Humans ; Hypoglycemic Agents/therapeutic use ; Intra-Abdominal Fat ; Liver ; Obesity ; PPAR gamma
Czasopismo naukowe
Tytuł :
Statin-Related New-Onset Diabetes Appears Driven by Increased Insulin Resistance: Are There Clinical Implications?
Autorzy :
Brinton EA; Utah Lipid Center, Salt Lake City.
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Źródło :
Arteriosclerosis, thrombosis, and vascular biology [Arterioscler Thromb Vasc Biol] 2021 Nov; Vol. 41 (11), pp. 2798-2801. Date of Electronic Publication: 2021 Oct 27.
Typ publikacji :
Editorial; Comment
MeSH Terms :
Cardiovascular Diseases*
Diabetes Mellitus, Type 2*/diagnosis
Diabetes Mellitus, Type 2*/drug therapy
Diabetes Mellitus, Type 2*/epidemiology
Hydroxymethylglutaryl-CoA Reductase Inhibitors*/adverse effects
Hyperinsulinism*
Insulin Resistance*
Humans
Opinia redakcyjna
Tytuł :
Aqueous Azadirachta indica (Neem) Extract Attenuates Insulin Resistance to Improve Glycemic Control and Endothelial Function in Subjects with Metabolic Syndrome.
Autorzy :
Pingali U; Department of Clinical Pharmacology & Therapeutics, Nizam's Institute of Medical Sciences, Hyderabad, India.
Vuppalanchi B; Department of Clinical Pharmacology & Therapeutics, Nizam's Institute of Medical Sciences, Hyderabad, India.
Nutalapati C; Department of Clinical Pharmacology & Therapeutics, Nizam's Institute of Medical Sciences, Hyderabad, India.
Gundagani S; Department of Clinical Pharmacology & Therapeutics, Nizam's Institute of Medical Sciences, Hyderabad, India.
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Źródło :
Journal of medicinal food [J Med Food] 2021 Nov; Vol. 24 (11), pp. 1135-1144. Date of Electronic Publication: 2021 Sep 28.
Typ publikacji :
Journal Article; Randomized Controlled Trial
MeSH Terms :
Azadirachta*
Insulin Resistance*
Metabolic Syndrome*/drug therapy
Glycemic Control ; Humans ; Plant Extracts
Czasopismo naukowe
Tytuł :
Curcumin Derivative MTH-3 Regulates Palmitate-induced Insulin Resistance in Mouse Myoblast C 2 C 12 Cells.
Autorzy :
Chiu YJ; Division of Plastic and Reconstructive Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C.; Department of Surgery, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan, R.O.C.; Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan, R.O.C.
Lo YH; Department of Biological Science and Technology, China Medical University, Taichung, Taiwan, R.O.C.; Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan, R.O.C.
Yang JS; Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan, R.O.C.
Kuo SC; Chinese Medicinal Research and Development Center, China Medical University Hospital, School of Pharmacy, China Medical University, Taichung, Taiwan, R.O.C.
Tsai SC; Department of Biological Science and Technology, China Medical University, Taichung, Taiwan, R.O.C.; .
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Źródło :
In vivo (Athens, Greece) [In Vivo] 2021 Nov-Dec; Vol. 35 (6), pp. 3181-3191.
Typ publikacji :
Journal Article
MeSH Terms :
Curcumin*/pharmacology
Insulin Resistance*
Animals ; Cell Line ; Insulin ; Mice ; Myoblasts ; Palmitates
Czasopismo naukowe
Tytuł :
Current and emerging gluconeogenesis inhibitors for the treatment of Type 2 diabetes.
Autorzy :
Rendell MS; The Association of Diabetes Investigators, Newport Coast, California, United States.; The Rose Salter Medical Research Foundation, Newport Coast, California, United States.
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Źródło :
Expert opinion on pharmacotherapy [Expert Opin Pharmacother] 2021 Nov; Vol. 22 (16), pp. 2167-2179. Date of Electronic Publication: 2021 Aug 05.
Typ publikacji :
Journal Article
MeSH Terms :
Diabetes Mellitus, Type 2*/drug therapy
Diabetes Mellitus, Type 2*/metabolism
Insulin Resistance*
Gluconeogenesis ; Glucose/metabolism ; Humans ; Insulin/metabolism ; Liver/metabolism
Czasopismo naukowe
Tytuł :
Docking protein 1 and free fatty acids are associated with insulin resistance in patients with type 2 diabetes mellitus.
Autorzy :
Ha X; Department of Clinical Laboratory, The People's Liberation Army Joint Service Support Unit 940 Hospital, Lanzhou, China.; The Second Hospital of Lanzhou University, Lanzhou, China.
Cai X; Department of Medical Laboratory, Qinghai Provincial People's Hospital, Xining, China.
Cao H; The Second Medical Centre of the Chinese People's Liberation Army General Hospital, Beijing, China.
Li J; The First People's Hospital of Baiyin, China.
Yang B; Department of Obstetrics and Gynaecology, Reproductive Medicine Centre, The First Affiliated Hospital of Anhui Medical University, Anhui, China.
Jiang R; Department of Haematology, Nanjing Drum Tower Hospital, Nanjing, China.
Li X; The Affiliated Lianyungang Oriental Hospital of Xuzhou Medical University, Xuzhou, China.
Li B; Department of Clinical Laboratory, The People's Liberation Army Joint Service Support Unit 940 Hospital, Lanzhou, China.
Xin Y; Department of Clinical Laboratory, The People's Liberation Army Joint Service Support Unit 940 Hospital, Lanzhou, China.
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Źródło :
The Journal of international medical research [J Int Med Res] 2021 Nov; Vol. 49 (11), pp. 3000605211048293.
Typ publikacji :
Journal Article
MeSH Terms :
Diabetes Mellitus, Type 2*/genetics
Insulin Resistance*
Prediabetic State*
Animals ; Blood Glucose ; Carboxypeptidases ; DNA-Binding Proteins ; Fatty Acids, Nonesterified ; Humans ; Insulin ; Mice ; Phosphoproteins ; RNA-Binding Proteins ; Repressor Proteins ; Retrospective Studies
Czasopismo naukowe
Tytuł :
The association between triglyceride-glucose index and major adverse cardiovascular events in patients with acute coronary syndrome - dose-response meta-analysis.
Autorzy :
Akbar MR; Department of Cardiology and Vascular Medicine, Faculty of Medicine Universitas Padjadjaran, Rumah Sakit Umum Pusat Hasan Sadikin, Bandung, Indonesia. Electronic address: .
Pranata R; Department of Cardiology and Vascular Medicine, Faculty of Medicine Universitas Padjadjaran, Rumah Sakit Umum Pusat Hasan Sadikin, Bandung, Indonesia; Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia. Electronic address: .
Wibowo A; Department of Cardiology and Vascular Medicine, Faculty of Medicine Universitas Padjadjaran, Rumah Sakit Umum Pusat Hasan Sadikin, Bandung, Indonesia. Electronic address: .
Irvan; Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia. Electronic address: .
Sihite TA; Department of Cardiology and Vascular Medicine, Faculty of Medicine Universitas Padjadjaran, Rumah Sakit Umum Pusat Hasan Sadikin, Bandung, Indonesia. Electronic address: .
Martha JW; Department of Cardiology and Vascular Medicine, Faculty of Medicine Universitas Padjadjaran, Rumah Sakit Umum Pusat Hasan Sadikin, Bandung, Indonesia. Electronic address: .
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Źródło :
Nutrition, metabolism, and cardiovascular diseases : NMCD [Nutr Metab Cardiovasc Dis] 2021 Oct 28; Vol. 31 (11), pp. 3024-3030. Date of Electronic Publication: 2021 Aug 12.
Typ publikacji :
Journal Article; Meta-Analysis; Systematic Review
MeSH Terms :
Insulin Resistance*
Acute Coronary Syndrome/*blood
Blood Glucose/*metabolism
Diabetes Mellitus/*blood
Triglycerides/*blood
Acute Coronary Syndrome/diagnosis ; Acute Coronary Syndrome/mortality ; Acute Coronary Syndrome/therapy ; Biomarkers/blood ; Diabetes Mellitus/diagnosis ; Disease Progression ; Humans ; Myocardial Revascularization ; Predictive Value of Tests ; Prognosis ; Risk Assessment ; Risk Factors
Czasopismo naukowe
Tytuł :
Changes in adiposity mediate the associations of diet quality with insulin sensitivity and beta-cell function.
Autorzy :
Lai KZH; Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Canada. Electronic address: .
Semnani-Azad Z; Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Canada. Electronic address: .
Retnakaran R; Division of Endocrinology and Metabolism, University of Toronto, Toronto, Canada; Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, Canada; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Canada. Electronic address: .
Harris SB; Department of Family Medicine, Western University, London, Canada. Electronic address: .
Hanley AJ; Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Canada; Division of Endocrinology and Metabolism, University of Toronto, Toronto, Canada; Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, Canada. Electronic address: .
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Źródło :
Nutrition, metabolism, and cardiovascular diseases : NMCD [Nutr Metab Cardiovasc Dis] 2021 Oct 28; Vol. 31 (11), pp. 3054-3063. Date of Electronic Publication: 2021 Jul 30.
Typ publikacji :
Journal Article; Observational Study; Research Support, Non-U.S. Gov't
MeSH Terms :
Adiposity*
Insulin Resistance*
Nutritive Value*
Blood Glucose/*metabolism
Diabetes Mellitus, Type 2/*blood
Diet/*adverse effects
Insulin/*blood
Insulin-Secreting Cells/*metabolism
Obesity/*physiopathology
Adult ; Biomarkers/blood ; Diabetes Mellitus, Type 2/diagnosis ; Diabetes Mellitus, Type 2/epidemiology ; Female ; Humans ; Longitudinal Studies ; Male ; Middle Aged ; Obesity/diagnosis ; Obesity/epidemiology ; Ontario/epidemiology ; Prognosis ; Prospective Studies ; Risk Assessment ; Risk Factors ; Time Factors ; Waist Circumference
Czasopismo naukowe
Tytuł :
NLRP3 inflammasome blocked the glycolytic pathway via targeting to PKLR in arsenic-induced hepatic insulin resistance.
Autorzy :
Zhang J; Occupational and Environmental Health Department, Dalian Medical University, 9 Lvshun South Road, Dalian 116044, PR China. Electronic address: .
Qiu T; Occupational and Environmental Health Department, Dalian Medical University, 9 Lvshun South Road, Dalian 116044, PR China. Electronic address: .
Jiang L; Experimental Teaching Center of Public Health, Dalian Medical University, 9 Lvshun South Road, Dalian 116044, PR China. Electronic address: .
Wang N; Nutrition and Food Hygiene, Dalian Medical University, 9 Lvshun South Road, Dalian 116044, PR China. Electronic address: .
Zhu Y; Occupational and Environmental Health Department, Dalian Medical University, 9 Lvshun South Road, Dalian 116044, PR China. Electronic address: .
Yan R; The Second Affiliated Hospital, Dalian Medical University, 467 Zhongshan Road, Dalian 116023, PR China. Electronic address: .
Wang S; The First Affiliated Hospital, Dalian Medical University, 222 Zhongshan Road, Dalian 116001, PR China. Electronic address: .
Bai J; Nutrition and Food Hygiene, Dalian Medical University, 9 Lvshun South Road, Dalian 116044, PR China. Electronic address: .
Shi X; Occupational and Environmental Health Department, Dalian Medical University, 9 Lvshun South Road, Dalian 116044, PR China. Electronic address: .
Yang G; Nutrition and Food Hygiene, Dalian Medical University, 9 Lvshun South Road, Dalian 116044, PR China. Electronic address: .
Liu X; Nutrition and Food Hygiene, Dalian Medical University, 9 Lvshun South Road, Dalian 116044, PR China. Electronic address: .
Yao X; Occupational and Environmental Health Department, Dalian Medical University, 9 Lvshun South Road, Dalian 116044, PR China. Electronic address: .
Sun X; Occupational and Environmental Health Department, Dalian Medical University, 9 Lvshun South Road, Dalian 116044, PR China; Global Health Research Center, Dalian Medical University, 9 Lvshun South Road, Dalian 116044, PR China. Electronic address: .
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Źródło :
Ecotoxicology and environmental safety [Ecotoxicol Environ Saf] 2021 Oct 15; Vol. 223, pp. 112590. Date of Electronic Publication: 2021 Aug 05.
Typ publikacji :
Journal Article
MeSH Terms :
Arsenic*/toxicity
Insulin Resistance*
Animals ; Inflammasomes ; Liver ; Mice ; Mice, Inbred C57BL ; NLR Family, Pyrin Domain-Containing 3 Protein/genetics ; Pyruvate Kinase
Czasopismo naukowe
Tytuł :
High fat diet and its effects on cognitive health: alterations of neuronal and vascular components of brain.
Autorzy :
Sharma S; Division of Medical Sciences, University of Victoria, PO Box 1700 STN CSC, Victoria, BC, V8W2Y2, Canada. Electronic address: .
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Źródło :
Physiology & behavior [Physiol Behav] 2021 Oct 15; Vol. 240, pp. 113528. Date of Electronic Publication: 2021 Jul 11.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Diabetes Mellitus, Type 2*
Insulin Resistance*
Animals ; Brain ; Cognition ; Diet, High-Fat/adverse effects ; Mice ; Mice, Inbred C57BL
Czasopismo naukowe
Tytuł :
Supplementation with a Specific Combination of Metabolic Cofactors Ameliorates Non-Alcoholic Fatty Liver Disease, Hepatic Fibrosis, and Insulin Resistance in Mice.
Autorzy :
Quesada-Vázquez S; Eurecat, Technology Centre of Catalunya, Nutrition and Health Unit, 43204 Reus, Spain.
Colom-Pellicer M; Nutrigenomics Research Group, Department of Biochemistry and Biotechnology, Universitat Rovira i Virgili, 43007 Tarragona, Spain.
Navarro-Masip È; Nutrigenomics Research Group, Department of Biochemistry and Biotechnology, Universitat Rovira i Virgili, 43007 Tarragona, Spain.
Aragonès G; Nutrigenomics Research Group, Department of Biochemistry and Biotechnology, Universitat Rovira i Virgili, 43007 Tarragona, Spain.
Del Bas JM; Eurecat, Technology Centre of Catalunya, Nutrition and Health Unit, 43204 Reus, Spain.
Caimari A; Eurecat, Centre Tecnològic de Catalunya, Biotechnology Area, 43204 Reus, Spain.
Escoté X; Eurecat, Technology Centre of Catalunya, Nutrition and Health Unit, 43204 Reus, Spain.
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Źródło :
Nutrients [Nutrients] 2021 Oct 09; Vol. 13 (10). Date of Electronic Publication: 2021 Oct 09.
Typ publikacji :
Journal Article
MeSH Terms :
Dietary Supplements*
Insulin Resistance*
Liver Cirrhosis/*metabolism
Non-alcoholic Fatty Liver Disease/*metabolism
Alanine Transaminase/blood ; Animals ; Aspartate Aminotransferases/blood ; Biomarkers/metabolism ; Fatty Acids/metabolism ; Gene Expression Regulation ; Lipid Metabolism ; Liver/injuries ; Liver/pathology ; Liver Cirrhosis/blood ; Male ; Mice, Inbred C57BL ; Non-alcoholic Fatty Liver Disease/blood ; Oxidation-Reduction ; RNA, Messenger/genetics ; RNA, Messenger/metabolism
Czasopismo naukowe
Tytuł :
GPR21 Inhibition Increases Glucose-Uptake in HepG2 Cells.
Autorzy :
Kinsella GK; School of Food Sciences and Environmental Health, Technological University Dublin, Grangegorman, D07 ADY7 Dublin, Ireland.
Cannito S; Department of Clinical and Biological Sciences, University of Turin, 10125 Turin, Italy.
Bordano V; Dipartimento di Scienza e Tecnologia del Farmaco, University of Turin, Via Pietro Giuria 9, 10125 Turin, Italy.
Stephens JC; Department of Chemistry, Maynooth University, Maynooth, Co. Kildare, Ireland.; Kathleen Lonsdale Institute for Human Health Research, Maynooth University, Maynooth, Co. Kildare, Ireland.
Rosa AC; Dipartimento di Scienza e Tecnologia del Farmaco, University of Turin, Via Pietro Giuria 9, 10125 Turin, Italy.
Miglio G; Dipartimento di Scienza e Tecnologia del Farmaco, University of Turin, Via Pietro Giuria 9, 10125 Turin, Italy.
Guaschino V; Dipartimento di Scienza e Tecnologia del Farmaco, University of Turin, Via Pietro Giuria 9, 10125 Turin, Italy.
Iannaccone V; Dipartimento di Scienza e Tecnologia del Farmaco, University of Turin, Via Pietro Giuria 9, 10125 Turin, Italy.
Findlay JBC; Department of Biology, Maynooth University, Maynooth, Co. Kildare, Ireland.; School of Biomedical Sciences, University of Leeds, LS2 9JT Leeds, UK.
Benetti E; Dipartimento di Scienza e Tecnologia del Farmaco, University of Turin, Via Pietro Giuria 9, 10125 Turin, Italy.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Oct 05; Vol. 22 (19). Date of Electronic Publication: 2021 Oct 05.
Typ publikacji :
Journal Article
MeSH Terms :
Insulin Resistance*
Glucose/*metabolism
Hepatocytes/*metabolism
Insulin/*metabolism
Receptors, G-Protein-Coupled/*antagonists & inhibitors
Hep G2 Cells ; Humans ; Signal Transduction
Czasopismo naukowe
Tytuł :
The triglyceride-glucose index is a more powerful surrogate marker for predicting the prevalence and incidence of type 2 diabetes mellitus than the homeostatic model assessment of insulin resistance.
Autorzy :
Park HM; Department of Family Medicine, Chaum Medical Checkup Center Samseongdong Branch, Cha University, Seoul 06125, Republic of Korea.
Lee HS; Biostatistics Collaboration Unit, Department of Research Affairs, Yonsei University College of Medicine, Seoul 06273, Republic of Korea.
Lee YJ; Department of Family Medicine, Yonsei University College of Medicine, Gangnam Severance Hospital, Seoul 06273, Republic of Korea.
Lee JH; Department of Family Medicine, Nowon Eulji Medical Center, Eulji University School of Medicine, Seoul 01830, Republic of Korea. Electronic address: .
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Źródło :
Diabetes research and clinical practice [Diabetes Res Clin Pract] 2021 Oct; Vol. 180, pp. 109042. Date of Electronic Publication: 2021 Sep 17.
Typ publikacji :
Journal Article
MeSH Terms :
Diabetes Mellitus, Type 2*/epidemiology
Insulin Resistance*
Adult ; Biomarkers ; Blood Glucose ; Glucose ; Humans ; Incidence ; Prevalence ; Triglycerides
Czasopismo naukowe
Tytuł :
Increased regulated on activation, normal T-cell expressed and secreted levels and cysteine-cysteine chemokine receptor 5 upregulation in omental adipose tissue and peripheral blood mononuclear cells are associated with testosterone level and insulin resistance in polycystic ovary syndrome.
Autorzy :
Juan CC; Institute of Physiology, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Department of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan.
Chen KH; Department of Obstetrics and Gynecology, Taipei Tzu-Chi Hospital, The Buddhist Tzu-Chi Medical Foundation, Taipei, Taiwan; School of Medicine, Buddhist Tzu-Chi University, Hualien, Taiwan.
Chen CW; College of Human Development and Health, National Taipei University of Nursing and Health Sciences, Taipei, Taiwan.
Ho CH; Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Obstetrics and Gynecology, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Wang PH; Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Obstetrics and Gynecology, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Chen HS; Internal Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Division of Endocrinology and Metabolism, Taipei Veterans General Hospital, Taipei, Taiwan.
Hwang JL; Department of Obstetrics and Gynecology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan; Department of Obstetrics and Gynecology, Taipei Medical University, Taipei, Taiwan; Taipei IVF, Taipei, Taiwan.
Lin YH; Department of Obstetrics and Gynecology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan; Department of Obstetrics and Gynecology, Taipei Medical University, Taipei, Taiwan; Fu-Jen Catholic University, New Taipei City, Taiwan.
Seow KM; Department of Obstetrics and Gynecology, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Department of Obstetrics and Gynecology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan. Electronic address: .
Pokaż więcej
Źródło :
Fertility and sterility [Fertil Steril] 2021 Oct; Vol. 116 (4), pp. 1139-1146. Date of Electronic Publication: 2021 Jun 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Insulin Resistance*
Abdominal Fat/*metabolism
Chemokine CCL5/*metabolism
Hyperandrogenism/*metabolism
Leukocytes, Mononuclear/*metabolism
Polycystic Ovary Syndrome/*metabolism
Receptors, CCR5/*metabolism
T-Lymphocytes/*metabolism
Testosterone/*blood
Abdominal Fat/immunology ; Abdominal Fat/physiopathology ; Adult ; Blood Glucose/metabolism ; C-Reactive Protein/analysis ; Case-Control Studies ; Female ; Humans ; Hyperandrogenism/diagnosis ; Hyperandrogenism/immunology ; Hyperandrogenism/physiopathology ; Insulin/blood ; Leukocytes, Mononuclear/immunology ; Lymphocyte Activation ; Omentum ; Polycystic Ovary Syndrome/diagnosis ; Polycystic Ovary Syndrome/immunology ; Polycystic Ovary Syndrome/physiopathology ; Receptors, CCR5/genetics ; T-Lymphocytes/immunology ; THP-1 Cells ; Up-Regulation ; Young Adult
Czasopismo naukowe
Tytuł :
Liubao brick tea activates the PI3K-Akt signaling pathway to lower blood glucose, metabolic disorders and insulin resistance via altering the intestinal flora.
Autorzy :
Zhu J; Institute of Food Engineering, College of Life Sciences, Shanghai Normal University, 100 Guilin Road, Xuhui District, Shanghai 200234, China.
Wu M; Institute of Food Engineering, College of Life Sciences, Shanghai Normal University, 100 Guilin Road, Xuhui District, Shanghai 200234, China.
Zhou H; Institute of Food Engineering, College of Life Sciences, Shanghai Normal University, 100 Guilin Road, Xuhui District, Shanghai 200234, China.
Cheng L; Department of Food Science & Technology, School of Agriculture and Biology, Shanghai Jiao Tong University, 800 Dongchuan Road, Minhang District, Shanghai 200240, China.
Wei X; Institute of Food Engineering, College of Life Sciences, Shanghai Normal University, 100 Guilin Road, Xuhui District, Shanghai 200234, China; Department of Food Science & Technology, School of Agriculture and Biology, Shanghai Jiao Tong University, 800 Dongchuan Road, Minhang District, Shanghai 200240, China. Electronic address: .
Wang Y; Institute of Food Engineering, College of Life Sciences, Shanghai Normal University, 100 Guilin Road, Xuhui District, Shanghai 200234, China. Electronic address: .
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Źródło :
Food research international (Ottawa, Ont.) [Food Res Int] 2021 Oct; Vol. 148, pp. 110594. Date of Electronic Publication: 2021 Jul 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gastrointestinal Microbiome*
Insulin Resistance*
Metabolic Diseases*/drug therapy
Animals ; Blood Glucose ; Mice ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Signal Transduction ; Tea
Czasopismo naukowe
Tytuł :
Oxylipin responses to fasting and insulin infusion in a large mammalian model of fasting-induced insulin resistance, the northern elephant seal.
Autorzy :
Wright DN; Department of Food Science and Nutrition, California Polytechnic State University, San Luis Obispo, California.
Katundu KGH; Division of Physiology, Biomedical Sciences Department, College of Medicine, University of Malawi, Blantyre, Malawi.
Viscarra JA; Department of Molecular & Cell Biology, School of Natural Sciences, University of California, Merced, California.
Crocker DE; Department of Biology, Sonoma State University, Rohnert Park, California.
Newman JW; Obesity and Metabolism Research Unit, United States Department of Agriculture-Agricultural Research Service Western Human Nutrition Research Center, University of California, Davis, California.; National Institutes of Health West Coast Metabolomics Center, University of California, Davis, California.; Department of Nutrition, University of California, Davis, California.
La Frano MR; Department of Food Science and Nutrition, California Polytechnic State University, San Luis Obispo, California.; Center for Health Research, California Polytechnic State University, San Luis Obispo, California.; Cal Poly Metabolomics Service Center, California Polytechnic State University, San Luis Obispo, California.
Ortiz RM; Department of Molecular & Cell Biology, School of Natural Sciences, University of California, Merced, California.
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Źródło :
American journal of physiology. Regulatory, integrative and comparative physiology [Am J Physiol Regul Integr Comp Physiol] 2021 Oct 01; Vol. 321 (4), pp. R537-R546. Date of Electronic Publication: 2021 Aug 04.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Insulin Resistance*
Fasting/*blood
Hypoglycemic Agents/*administration & dosage
Insulin/*administration & dosage
Lipid Metabolism/*drug effects
Oxylipins/*blood
Seals, Earless/*blood
Animals ; Biomarkers/blood ; Infusions, Parenteral
Czasopismo naukowe

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