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Wyszukujesz frazę ""integrin alphaVbeta3"" wg kryterium: Temat


Tytuł :
Vitronectin-activated αvβ3 and αvβ5 integrin signalling specifies haematopoietic fate in human pluripotent stem cells.
Autorzy :
Shen J; State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Tianjin, China.
Zhu Y; State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Tianjin, China.
Zhang S; State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Tianjin, China.
Lyu S; State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Tianjin, China.
Lyu C; Department of Hematology, the First Central Hospital of Tianjin, Tianjin, China.
Feng Z; Center of Reproductive Medicine, Tianjin Central Hospital of Gynaecology and Obstetrics, Tianjin, China.
Hoyle DL; Division of Hematology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Wang ZZ; Division of Hematology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Cheng T; State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Tianjin, China.; Department of Stem Cell and Regenerative Medicine, Peking Union Medical College, Tianjin, China.; Tianjin Key Laboratory of Blood Cell Therapy and Technology, Tianjin, China.
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Źródło :
Cell proliferation [Cell Prolif] 2021 Apr; Vol. 54 (4), pp. e13012. Date of Electronic Publication: 2021 Mar 03.
Typ publikacji :
Journal Article
MeSH Terms :
Cell Differentiation/*drug effects
Integrin alphaVbeta3/*metabolism
Receptors, Vitronectin/*metabolism
Vitronectin/*pharmacology
Cell Adhesion/drug effects ; Cell Line ; Gene Expression Regulation ; Hematopoietic Stem Cells/cytology ; Hematopoietic Stem Cells/metabolism ; Homeodomain Proteins/genetics ; Homeodomain Proteins/metabolism ; Humans ; Integrin alphaVbeta3/antagonists & inhibitors ; Integrin alphaVbeta3/genetics ; Mesoderm/cytology ; Mesoderm/growth & development ; Mesoderm/metabolism ; Pluripotent Stem Cells/cytology ; Pluripotent Stem Cells/metabolism ; RNA Interference ; RNA, Small Interfering/metabolism ; Receptors, Vitronectin/antagonists & inhibitors ; Receptors, Vitronectin/genetics ; Signal Transduction/drug effects ; Snake Venoms/pharmacology
Czasopismo naukowe
Tytuł :
Measurement of Integrin Activation and Conformational Changes on the Cell Surface by Soluble Ligand and Antibody Binding Assays.
Autorzy :
Wang Z; Blood Research Institute, Versiti, Milwaukee, WI, USA.
Zhu J; Blood Research Institute, Versiti, Milwaukee, WI, USA. .; Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI, USA. .
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Źródło :
Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2021; Vol. 2217, pp. 3-15.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Biological Assay*
Integrin alphaVbeta3/*chemistry
Lymphocyte Function-Associated Antigen-1/*chemistry
Platelet Membrane Glycoprotein IIb/*chemistry
Receptors, Vitronectin/*chemistry
Staining and Labeling/*methods
Animals ; Antibodies/chemistry ; Antibodies/metabolism ; CHO Cells ; Cell Adhesion ; Cricetulus ; Flow Cytometry ; Fluorescent Dyes/chemistry ; HEK293 Cells ; Humans ; Immunoconjugates/chemistry ; Immunoconjugates/metabolism ; Integrin alphaVbeta3/genetics ; Integrin alphaVbeta3/metabolism ; Intercellular Adhesion Molecule-1 ; Ligands ; Lymphocyte Function-Associated Antigen-1/genetics ; Lymphocyte Function-Associated Antigen-1/metabolism ; Mice ; Plasmids/chemistry ; Plasmids/metabolism ; Platelet Membrane Glycoprotein IIb/genetics ; Platelet Membrane Glycoprotein IIb/metabolism ; Protein Binding ; Receptors, Vitronectin/genetics ; Receptors, Vitronectin/metabolism ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Transfection
Czasopismo naukowe
Tytuł :
Molecular dynamics simulations to the bidirectional adhesion signaling pathway of integrin α V β 3 .
Autorzy :
Kulke M; Institut für Biochemie, Universität Greifswald, Greifswald, Germany.
Langel W; Institut für Biochemie, Universität Greifswald, Greifswald, Germany.
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Źródło :
Proteins [Proteins] 2020 May; Vol. 88 (5), pp. 679-688. Date of Electronic Publication: 2019 Nov 18.
Typ publikacji :
Journal Article
MeSH Terms :
1,2-Dipalmitoylphosphatidylcholine/*chemistry
Integrin alphaVbeta3/*chemistry
1,2-Dipalmitoylphosphatidylcholine/metabolism ; Binding Sites ; Cell Membrane/chemistry ; Cell Membrane/metabolism ; Crystallography, X-Ray ; Extracellular Matrix/chemistry ; Extracellular Matrix/metabolism ; Humans ; Integrin alphaVbeta3/genetics ; Integrin alphaVbeta3/metabolism ; Molecular Dynamics Simulation ; Principal Component Analysis ; Protein Binding ; Protein Conformation, alpha-Helical ; Protein Conformation, beta-Strand ; Protein Interaction Domains and Motifs ; Thermodynamics
Czasopismo naukowe
Tytuł :
Multimeric Presentation of RGD Peptidomimetics Enhances Integrin Binding and Tumor Cell Uptake.
Autorzy :
Pina A; Università degli Studi di Milano, Dipartimento di Chimica, Via C. Golgi 19, 20133, Milan, Italy.
Kadri M; Institute for Advanced Biosciences, University Grenoble Alpes, INSERM, CNRS, Site Santé, Allée des Alpes, 38700, La Tronche, France.
Arosio D; CNR, Istituto di Scienze e Tecnologie Chimiche (SCITEC) 'Giulio Natta', Via C. Golgi, 19, 20133, Milan, Italy.
Dal Corso A; Università degli Studi di Milano, Dipartimento di Chimica, Via C. Golgi 19, 20133, Milan, Italy.
Coll JL; Institute for Advanced Biosciences, University Grenoble Alpes, INSERM, CNRS, Site Santé, Allée des Alpes, 38700, La Tronche, France.
Gennari C; Università degli Studi di Milano, Dipartimento di Chimica, Via C. Golgi 19, 20133, Milan, Italy.
Boturyn D; Department of Molecular Chemistry, University Grenoble Alpes, CNRS, 570, rue de la chimie, CS 40700, 38041, GRENOBLE Cedex 9, France.
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Źródło :
Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2020 Jun 10; Vol. 26 (33), pp. 7492-7496. Date of Electronic Publication: 2020 May 19.
Typ publikacji :
Journal Article
MeSH Terms :
Integrin alphaVbeta3/*metabolism
Oligopeptides/*chemistry
Peptidomimetics/*chemistry
Biological Transport ; Humans ; Integrin alphaVbeta3/chemistry ; Ligands ; Oligopeptides/metabolism ; Oligopeptides/pharmacokinetics ; Oligopeptides/pharmacology
Czasopismo naukowe
Tytuł :
WISP1 Protects Against Chondrocyte Senescence and Apoptosis by Regulating αvβ3 and PI3K/Akt Pathway in Osteoarthritis.
Autorzy :
Cheng C; Department of Orthopaedics, Yiyang Central Hospital, Yiyang, China.; Clinical Medical Technology Demonstration Base for Minimally Invasive and Digital Orthopaedics in Hunan Province, Yiyang, China.
Tian J; Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, China.
Zhang F; Department of Emergency, Xiangya Hospital, Central South University, Changsha, China.
Deng Z; Department of Sports Medicine, the First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, China.
Tu M; Department of Orthopedics, Second People's Hospital of Jingmen, Jingmen, China.
Li L; Department of Orthopedic, Changsha Central Hospital, Changsha, China.
Yang H; Department of Orthopaedics, Yiyang Central Hospital, Yiyang, China.; Clinical Medical Technology Demonstration Base for Minimally Invasive and Digital Orthopaedics in Hunan Province, Yiyang, China.
Xiao K; Department of Orthopaedics, Yiyang Central Hospital, Yiyang, China.; Clinical Medical Technology Demonstration Base for Minimally Invasive and Digital Orthopaedics in Hunan Province, Yiyang, China.
Guo W; Department of Orthopaedics, Yiyang Central Hospital, Yiyang, China.; Clinical Medical Technology Demonstration Base for Minimally Invasive and Digital Orthopaedics in Hunan Province, Yiyang, China.
Yang R; Department of Orthopaedics, Yiyang Central Hospital, Yiyang, China.; Clinical Medical Technology Demonstration Base for Minimally Invasive and Digital Orthopaedics in Hunan Province, Yiyang, China.
Gao S; Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, China.
Zhou Z; Department of Orthopaedics, Yiyang Central Hospital, Yiyang, China.; Clinical Medical Technology Demonstration Base for Minimally Invasive and Digital Orthopaedics in Hunan Province, Yiyang, China.
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Źródło :
DNA and cell biology [DNA Cell Biol] 2021 Apr; Vol. 40 (4), pp. 629-637. Date of Electronic Publication: 2021 Mar 01.
Typ publikacji :
Journal Article
MeSH Terms :
CCN Intercellular Signaling Proteins/*metabolism
Chondrocytes/*metabolism
Osteoarthritis, Knee/*metabolism
Proto-Oncogene Proteins/*metabolism
Adult ; Aging/physiology ; Animals ; Apoptosis/physiology ; CCN Intercellular Signaling Proteins/physiology ; Cartilage, Articular/metabolism ; Female ; Humans ; Integrin alphaVbeta3/metabolism ; Interleukin-1beta/metabolism ; Male ; MicroRNAs/metabolism ; Middle Aged ; Osteoarthritis/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins/physiology ; Proto-Oncogene Proteins c-akt/metabolism ; Rats ; Rats, Sprague-Dawley ; Signal Transduction ; TOR Serine-Threonine Kinases/metabolism
Czasopismo naukowe
Tytuł :
Transforming Growth Factor-induced Protein Promotes NF-κB-mediated Angiogenesis during Postnatal Lung Development.
Autorzy :
Liu M; Department of Pediatrics, Center for Excellence in Pulmonary Biology, and.
Iosef C; Department of Pediatrics, Center for Excellence in Pulmonary Biology, and.
Rao S; Department of Pediatrics, Center for Excellence in Pulmonary Biology, and.
Domingo-Gonzalez R; Department of Pediatrics, Center for Excellence in Pulmonary Biology, and.
Fu S; Department of Pediatrics, Center for Excellence in Pulmonary Biology, and.; Liuyang People's Hospital, Hunan, China.
Snider P; Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana.
Conway SJ; Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana.
Umbach GS; Department of Pediatrics, Center for Excellence in Pulmonary Biology, and.; University of Texas Southwestern Medical School, Dallas, Texas; and.
Heilshorn SC; Department of Materials Science and Engineering, Stanford University, Stanford, California.
Dewi RE; Department of Materials Science and Engineering, Stanford University, Stanford, California.
Dahl MJ; Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah.
Null DM; Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah.
Albertine KH; Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah.
Alvira CM; Department of Pediatrics, Center for Excellence in Pulmonary Biology, and.
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Źródło :
American journal of respiratory cell and molecular biology [Am J Respir Cell Mol Biol] 2021 Mar; Vol. 64 (3), pp. 318-330.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Neovascularization, Physiologic*
Extracellular Matrix Proteins/*metabolism
Lung/*blood supply
Lung/*growth & development
NF-kappa B/*metabolism
Transforming Growth Factor beta/*metabolism
Animals ; Animals, Newborn ; Cell Movement ; Colony-Stimulating Factors/metabolism ; Endothelial Cells/metabolism ; Integrin alphaVbeta3/metabolism ; Mice, Inbred C57BL ; Nitric Oxide/biosynthesis ; Premature Birth ; Pulmonary Alveoli/metabolism ; Sheep
Czasopismo naukowe
Tytuł :
Extracellular Matrix Derived from High Metastatic Human Breast Cancer Triggers Epithelial-Mesenchymal Transition in Epithelial Breast Cancer Cells through αvβ3 Integrin.
Autorzy :
M Brandão-Costa R; Laboratory of Cellular and Molecular Pharmacology, Department of Cell Biology, IBRAG, Rio de Janeiro State University, Rio de Janeiro (RJ) 20551-030, Brazil.
Helal-Neto E; Laboratory of Cellular and Molecular Pharmacology, Department of Cell Biology, IBRAG, Rio de Janeiro State University, Rio de Janeiro (RJ) 20551-030, Brazil.
M Vieira A; Laboratory of Endothelial Cell and Angiogenesis, IBRAG, Rio de Janeiro State University, Rio de Janeiro (RJ) 20550-900, Brazil.
Barcellos-de-Souza P; Cellular and Molecular Oncobiology Program, Instituto Nacional de Câncer, Rio de Janeiro (RJ) 20231-050, Brazil.
Morgado-Diaz J; Cellular and Molecular Oncobiology Program, Instituto Nacional de Câncer, Rio de Janeiro (RJ) 20231-050, Brazil.
Barja-Fidalgo C; Laboratory of Cellular and Molecular Pharmacology, Department of Cell Biology, IBRAG, Rio de Janeiro State University, Rio de Janeiro (RJ) 20551-030, Brazil.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Apr 23; Vol. 21 (8). Date of Electronic Publication: 2020 Apr 23.
Typ publikacji :
Journal Article
MeSH Terms :
Epithelial-Mesenchymal Transition*/genetics
Breast Neoplasms/*metabolism
Breast Neoplasms/*pathology
Extracellular Matrix/*metabolism
Integrin alphaVbeta3/*metabolism
Breast Neoplasms/genetics ; Cell Line, Tumor ; Cell Movement ; Cell Proliferation ; Female ; Humans ; Integrin alphaVbeta3/genetics ; Protein Binding ; Signal Transduction ; Transforming Growth Factor beta/metabolism
Czasopismo naukowe
Tytuł :
An octopus-mimic PEGylated peptide as a specific integrin αvβ3 inhibitor for preventing tumor progression.
Autorzy :
Shan X; National Laboratory of Solid State Microstructures, College of Engineering and Applied Sciences, Nanjing University, Nanjing 210093, China. (ChemBIC), Nanjing University, Nanjing 210093, China.
Zhang L; National Laboratory of Solid State Microstructures, College of Engineering and Applied Sciences, Nanjing University, Nanjing 210093, China. (ChemBIC), Nanjing University, Nanjing 210093, China and The Center of Diagnosis and Treatment for Joint Disease, Drum Tower Hospital Affiliated to Medical School of Nanjing University, Nanjing 210093, China.
Xu Y; National Laboratory of Solid State Microstructures, College of Engineering and Applied Sciences, Nanjing University, Nanjing 210093, China. (ChemBIC), Nanjing University, Nanjing 210093, China.
Sun L; National Laboratory of Solid State Microstructures, College of Engineering and Applied Sciences, Nanjing University, Nanjing 210093, China. (ChemBIC), Nanjing University, Nanjing 210093, China.
Guo L; State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases, Center of Drug Discovery, Center of Advanced Pharmaceutics and Biomaterials, China Pharmaceutical University, Nanjing 210009, China.
Feng S; National Laboratory of Solid State Microstructures, College of Engineering and Applied Sciences, Nanjing University, Nanjing 210093, China. (ChemBIC), Nanjing University, Nanjing 210093, China.
Ge H; National Laboratory of Solid State Microstructures, College of Engineering and Applied Sciences, Nanjing University, Nanjing 210093, China. .
Gu T; National Laboratory of Solid State Microstructures, College of Engineering and Applied Sciences, Nanjing University, Nanjing 210093, China. (ChemBIC), Nanjing University, Nanjing 210093, China.
Ning X; National Laboratory of Solid State Microstructures, College of Engineering and Applied Sciences, Nanjing University, Nanjing 210093, China. (ChemBIC), Nanjing University, Nanjing 210093, China.
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Źródło :
Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2020 Feb 18; Vol. 56 (14), pp. 2178-2181. Date of Electronic Publication: 2020 Jan 23.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents/*pharmacology
Integrin alphaVbeta3/*antagonists & inhibitors
Peptides/*pharmacology
Polyethylene Glycols/*pharmacology
Animals ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Humans ; Integrin alphaVbeta3/metabolism ; Mice ; Mice, Nude ; Neoplasms, Experimental/drug therapy ; Neoplasms, Experimental/metabolism ; Neoplasms, Experimental/pathology ; Peptides/chemical synthesis ; Peptides/chemistry ; Polyethylene Glycols/chemical synthesis ; Polyethylene Glycols/chemistry ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Integrin Subtypes and Nanoscale Ligand Presentation Influence Drug Sensitivity in Cancer Cells.
Autorzy :
Young JL; Department of Cellular Biophysics , Max Planck Institute for Medical Research , 69120 Heidelberg , Germany.; Department of Biophysical Chemistry , Heidelberg University , 69120 Heidelberg , Germany.
Hua X; Department of Cellular Biophysics , Max Planck Institute for Medical Research , 69120 Heidelberg , Germany.; Department of Biophysical Chemistry , Heidelberg University , 69120 Heidelberg , Germany.
Somsel H; Department of Cellular Biophysics , Max Planck Institute for Medical Research , 69120 Heidelberg , Germany.; Department of Biophysical Chemistry , Heidelberg University , 69120 Heidelberg , Germany.
Reichart F; Department of Chemistry , Technical University of Munich , 85748 Garching , Germany.
Kessler H; Department of Chemistry , Technical University of Munich , 85748 Garching , Germany.
Spatz JP; Department of Cellular Biophysics , Max Planck Institute for Medical Research , 69120 Heidelberg , Germany.; Department of Biophysical Chemistry , Heidelberg University , 69120 Heidelberg , Germany.
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Źródło :
Nano letters [Nano Lett] 2020 Feb 12; Vol. 20 (2), pp. 1183-1191. Date of Electronic Publication: 2020 Jan 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Breast Neoplasms/*drug therapy
Cell Adhesion/*genetics
Integrin alpha5beta1/*genetics
Integrin alphaVbeta3/*genetics
Breast Neoplasms/genetics ; Breast Neoplasms/pathology ; Cell Adhesion/drug effects ; Cell Movement/genetics ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Drug Resistance, Neoplasm/drug effects ; Drug Resistance, Neoplasm/genetics ; Female ; Fibronectins/chemistry ; Fibronectins/genetics ; Gold/chemistry ; Humans ; Integrin alpha5beta1/chemistry ; Integrin alphaVbeta3/chemistry ; Ligands ; Metal Nanoparticles/chemistry ; Protein Binding/drug effects ; Signal Transduction/drug effects
Czasopismo naukowe
Tytuł :
Imaging Fibrogenesis in a Diet-Induced Model of Nonalcoholic Steatohepatitis (NASH).
Autorzy :
Hartimath SV; Singapore Bioimaging Consortium, Agency for Science Technology and Research (A∗STAR), 11 Biopolis Way, #01-02 Helios, Singapore 138667, Singapore.
Boominathan R; Singapore Bioimaging Consortium, Agency for Science Technology and Research (A∗STAR), 11 Biopolis Way, #01-02 Helios, Singapore 138667, Singapore.
Soh V; Singapore Bioimaging Consortium, Agency for Science Technology and Research (A∗STAR), 11 Biopolis Way, #01-02 Helios, Singapore 138667, Singapore.
Cheng P; Singapore Bioimaging Consortium, Agency for Science Technology and Research (A∗STAR), 11 Biopolis Way, #01-02 Helios, Singapore 138667, Singapore.
Deng X; Singapore Bioimaging Consortium, Agency for Science Technology and Research (A∗STAR), 11 Biopolis Way, #01-02 Helios, Singapore 138667, Singapore.
Chong YC; Singapore Bioimaging Consortium, Agency for Science Technology and Research (A∗STAR), 11 Biopolis Way, #01-02 Helios, Singapore 138667, Singapore.
Yong FF; Singapore Bioimaging Consortium, Agency for Science Technology and Research (A∗STAR), 11 Biopolis Way, #01-02 Helios, Singapore 138667, Singapore.
Tan PW; Singapore Bioimaging Consortium, Agency for Science Technology and Research (A∗STAR), 11 Biopolis Way, #01-02 Helios, Singapore 138667, Singapore.
Han W; Singapore Bioimaging Consortium, Agency for Science Technology and Research (A∗STAR), 11 Biopolis Way, #01-02 Helios, Singapore 138667, Singapore.
Robins EG; Singapore Bioimaging Consortium, Agency for Science Technology and Research (A∗STAR), 11 Biopolis Way, #01-02 Helios, Singapore 138667, Singapore.; Clinical Imaging Research Centre (A∗STAR-NUS), Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117599, Singapore.
Goggi JL; Singapore Bioimaging Consortium, Agency for Science Technology and Research (A∗STAR), 11 Biopolis Way, #01-02 Helios, Singapore 138667, Singapore.
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Źródło :
Contrast media & molecular imaging [Contrast Media Mol Imaging] 2019 Dec 01; Vol. 2019, pp. 6298128. Date of Electronic Publication: 2019 Dec 01 (Print Publication: 2019).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Positron-Emission Tomography*
Diet, High-Fat/*adverse effects
Hepatic Stellate Cells/*ultrastructure
Integrin alphaVbeta3/*analysis
Liver Cirrhosis/*diagnostic imaging
Non-alcoholic Fatty Liver Disease/*diagnostic imaging
Actins/biosynthesis ; Actins/genetics ; Animals ; Choline Deficiency/complications ; Collagen/biosynthesis ; Collagen/genetics ; Disease Progression ; Early Diagnosis ; Fluorine Radioisotopes ; Gene Expression Regulation ; Hepatic Stellate Cells/chemistry ; Hydroxyproline/analysis ; Integrin alphaVbeta3/biosynthesis ; Integrin alphaVbeta3/genetics ; Liver/chemistry ; Liver Cirrhosis/etiology ; Liver Cirrhosis/pathology ; Male ; Mice ; Mice, Inbred C57BL ; Non-alcoholic Fatty Liver Disease/etiology ; Non-alcoholic Fatty Liver Disease/pathology ; Organ Size ; RNA, Messenger/biosynthesis ; Radiopharmaceuticals ; Severity of Illness Index ; Triglycerides/analysis
Czasopismo naukowe
Tytuł :
Redox-Responsive Polymeric RNAi Based on Multivalent Conjugation of siRNA for Improved Intracellular Delivery.
Autorzy :
Bai Q; Department of Pharmacy , Affiliated Zhongshan Hospital of Dalian University , Dalian 116001 , China.
Liu J; Department of Neurosurgery , First Affiliated Hospital, School of Medicine, Zhejiang University , Hangzhou 310003 , China.; Ningbo Hygeia Medical Technology Co., Ltd. , No. 6 Jinyuan Road, High-Tech Zone , Ningbo 315201 , China.
Tang J; Ningbo Hygeia Medical Technology Co., Ltd. , No. 6 Jinyuan Road, High-Tech Zone , Ningbo 315201 , China.
Li Z; College of Pharmacy , Dalian Medical University , No. 9 West Section Lvshun South Road , Dalian 116044 , China.
Zheng X; Department of Neurosurgery , First Affiliated Hospital, School of Medicine, Zhejiang University , Hangzhou 310003 , China.
Chen Q; Ningbo Hygeia Medical Technology Co., Ltd. , No. 6 Jinyuan Road, High-Tech Zone , Ningbo 315201 , China.; School of Bioengineering , Dalian University of Technology , No. 2 Linggong Road , Dalian 116024 , China.
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Źródło :
Bioconjugate chemistry [Bioconjug Chem] 2019 Nov 20; Vol. 30 (11), pp. 2777-2781. Date of Electronic Publication: 2019 Oct 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Silencing*
Glioma/*genetics
Integrin alphaVbeta3/*antagonists & inhibitors
Oligopeptides/*chemistry
Polymers/*chemistry
RNA, Small Interfering/*administration & dosage
Receptors, Vitronectin/*antagonists & inhibitors
Drug Delivery Systems ; Glioma/metabolism ; Glioma/pathology ; Humans ; Integrin alphaVbeta3/genetics ; Integrin alphaVbeta3/metabolism ; Oxidation-Reduction ; RNA, Small Interfering/genetics ; Receptors, Vitronectin/genetics ; Receptors, Vitronectin/metabolism ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
Av β 3 Single-Stranded DNA Aptamer Attenuates Vascular Smooth Muscle Cell Proliferation and Migration via Ras-PI3K/MAPK Pathway.
Autorzy :
Wu HB; Department of Cardiovascular Surgery, Renmin Hospital of Wuhan University, Wuhan, China.
Wang ZW; Department of Cardiovascular Surgery, Renmin Hospital of Wuhan University, Wuhan, China.
Shi F; Department of Cardiovascular Surgery, Renmin Hospital of Wuhan University, Wuhan, China.
Ren ZL; Department of Cardiovascular Surgery, Renmin Hospital of Wuhan University, Wuhan, China.
Li LC; Department of Cardiovascular Surgery, Renmin Hospital of Wuhan University, Wuhan, China.
Hu XP; Department of Cardiovascular Surgery, Renmin Hospital of Wuhan University, Wuhan, China.
Hu R; Department of Cardiovascular Surgery, Renmin Hospital of Wuhan University, Wuhan, China.
Li BW; Department of Cardiovascular Surgery, Renmin Hospital of Wuhan University, Wuhan, China.
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Źródło :
Cardiovascular therapeutics [Cardiovasc Ther] 2020 Jan 21; Vol. 2020, pp. 6869856. Date of Electronic Publication: 2020 Jan 21 (Print Publication: 2020).
Typ publikacji :
Journal Article
MeSH Terms :
Cell Movement*
Cell Proliferation*
Aptamers, Nucleotide/*metabolism
DNA, Single-Stranded/*metabolism
Integrin alphaVbeta3/*metabolism
Mitogen-Activated Protein Kinases/*metabolism
Muscle, Smooth, Vascular/*enzymology
Myocytes, Smooth Muscle/*enzymology
Phosphatidylinositol 3-Kinases/*metabolism
ras Proteins/*metabolism
Animals ; Apoptosis ; Apoptosis Regulatory Proteins/genetics ; Apoptosis Regulatory Proteins/metabolism ; Aptamers, Nucleotide/genetics ; Cells, Cultured ; DNA, Single-Stranded/genetics ; Focal Adhesion Kinase 1/genetics ; Focal Adhesion Kinase 1/metabolism ; Gene Expression Regulation ; Integrin alphaVbeta3/genetics ; Mitogen-Activated Protein Kinases/genetics ; Muscle, Smooth, Vascular/pathology ; Myocytes, Smooth Muscle/pathology ; Osteopontin/genetics ; Osteopontin/metabolism ; Phosphatidylinositol 3-Kinases/genetics ; Phosphorylation ; Rats, Sprague-Dawley ; Signal Transduction ; ras Proteins/genetics
Czasopismo naukowe
Tytuł :
Evaluation of an Integrin α v β 3 and Aminopeptidase N Dual-Receptor Targeting Tracer for Breast Cancer Imaging.
Autorzy :
Gai Y; Department of Nuclear Medicine, Union Hospital, Tongji Medical College , Huazhong University of Science and Technology , Wuhan 430022 , China.; Hubei Province Key Laboratory of Molecular Imaging , Wuhan 430022 , China.
Jiang Y; Department of Nuclear Medicine, Union Hospital, Tongji Medical College , Huazhong University of Science and Technology , Wuhan 430022 , China.; Hubei Province Key Laboratory of Molecular Imaging , Wuhan 430022 , China.
Long Y; Department of Nuclear Medicine, Union Hospital, Tongji Medical College , Huazhong University of Science and Technology , Wuhan 430022 , China.; Hubei Province Key Laboratory of Molecular Imaging , Wuhan 430022 , China.
Sun L; Center for Radiochemistry Research, Department of Diagnostic Radiology , Oregon Health & Science University , Portland , Oregon 97239 , United States.
Liu Q; Department of Nuclear Medicine, Union Hospital, Tongji Medical College , Huazhong University of Science and Technology , Wuhan 430022 , China.; Hubei Province Key Laboratory of Molecular Imaging , Wuhan 430022 , China.
Qin C; Department of Nuclear Medicine, Union Hospital, Tongji Medical College , Huazhong University of Science and Technology , Wuhan 430022 , China.; Hubei Province Key Laboratory of Molecular Imaging , Wuhan 430022 , China.
Zhang Y; Department of Nuclear Medicine, Union Hospital, Tongji Medical College , Huazhong University of Science and Technology , Wuhan 430022 , China.; Hubei Province Key Laboratory of Molecular Imaging , Wuhan 430022 , China.
Zeng D; Center for Radiochemistry Research, Department of Diagnostic Radiology , Oregon Health & Science University , Portland , Oregon 97239 , United States.
Lan X; Department of Nuclear Medicine, Union Hospital, Tongji Medical College , Huazhong University of Science and Technology , Wuhan 430022 , China.; Hubei Province Key Laboratory of Molecular Imaging , Wuhan 430022 , China.
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Źródło :
Molecular pharmaceutics [Mol Pharm] 2020 Jan 06; Vol. 17 (1), pp. 349-358. Date of Electronic Publication: 2019 Dec 26.
Typ publikacji :
Evaluation Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Positron Emission Tomography Computed Tomography*
Breast Neoplasms/*diagnostic imaging
CD13 Antigens/*metabolism
Integrin alphaVbeta3/*metabolism
Radiopharmaceuticals/*administration & dosage
Animals ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; CD13 Antigens/antagonists & inhibitors ; Cell Line, Tumor ; Female ; Gallium Radioisotopes ; Humans ; Integrin alphaVbeta3/antagonists & inhibitors ; Lung Neoplasms/diagnostic imaging ; Lung Neoplasms/metabolism ; Lung Neoplasms/secondary ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Oligopeptides/chemistry ; Radiopharmaceuticals/chemistry ; Radiopharmaceuticals/metabolism ; Radiopharmaceuticals/pharmacokinetics ; Tissue Distribution ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
The dosage-dependent prenatal caffeine exposure adversely affects levels of integrin αVβ3 and MMP-9 in a rat model of embryo implantation.
Autorzy :
Yilmaz F
Tekmen I
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Źródło :
Bratislavske lekarske listy [Bratisl Lek Listy] 2020; Vol. 121 (9), pp. 648-655.
Typ publikacji :
Journal Article
MeSH Terms :
Caffeine*/adverse effects
Embryo Implantation*
Integrin alphaVbeta3*/metabolism
Matrix Metalloproteinase 9*/metabolism
Prenatal Exposure Delayed Effects*
Animals ; Female ; Pregnancy ; Rats ; Rats, Wistar
Czasopismo naukowe
Tytuł :
Multifunctional Glycoconjugates for Recruiting Natural Antibodies against Cancer Cells.
Autorzy :
Liet B; DCM, UMR 5250, Université Grenoble Alpes, CNRS, 38000, Grenoble, France.
Laigre E; DCM, UMR 5250, Université Grenoble Alpes, CNRS, 38000, Grenoble, France.
Goyard D; DCM, UMR 5250, Université Grenoble Alpes, CNRS, 38000, Grenoble, France.
Todaro B; DCM, UMR 5250, Université Grenoble Alpes, CNRS, 38000, Grenoble, France.
Tiertant C; DCM, UMR 5250, Université Grenoble Alpes, CNRS, 38000, Grenoble, France.
Boturyn D; DCM, UMR 5250, Université Grenoble Alpes, CNRS, 38000, Grenoble, France.
Berthet N; DCM, UMR 5250, Université Grenoble Alpes, CNRS, 38000, Grenoble, France.
Renaudet O; DCM, UMR 5250, Université Grenoble Alpes, CNRS, 38000, Grenoble, France.
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Źródło :
Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2019 Dec 05; Vol. 25 (68), pp. 15508-15515. Date of Electronic Publication: 2019 Oct 15.
Typ publikacji :
Journal Article
MeSH Terms :
Antibodies/*immunology
Glycoconjugates/*chemistry
Integrin alphaVbeta3/*metabolism
Rhamnose/*chemistry
Cell Line, Tumor ; Click Chemistry ; Flow Cytometry ; Humans ; Immunization ; Integrin alphaVbeta3/chemistry ; Ligands
Czasopismo naukowe
Tytuł :
Integrin αvβ3-Mediated Effects of Thyroid Hormones on Mesenchymal Stem Cells in Tumor Angiogenesis.
Autorzy :
Schmohl KA; Department of Internal Medicine IV, University Hospital of Munich, LMU Munich, Munich, Germany.
Mueller AM; Department of Internal Medicine IV, University Hospital of Munich, LMU Munich, Munich, Germany.
Dohmann M; Department of Internal Medicine IV, University Hospital of Munich, LMU Munich, Munich, Germany.
Spellerberg R; Department of Internal Medicine IV, University Hospital of Munich, LMU Munich, Munich, Germany.
Urnauer S; Department of Internal Medicine IV, University Hospital of Munich, LMU Munich, Munich, Germany.
Schwenk N; Department of Internal Medicine IV, University Hospital of Munich, LMU Munich, Munich, Germany.
Ziegler SI; Department of Nuclear Medicine, University Hospital of Munich, LMU Munich, Munich, Germany.
Bartenstein P; Department of Nuclear Medicine, University Hospital of Munich, LMU Munich, Munich, Germany.
Nelson PJ; Department of Internal Medicine IV, University Hospital of Munich, LMU Munich, Munich, Germany.
Spitzweg C; Department of Internal Medicine IV, University Hospital of Munich, LMU Munich, Munich, Germany.
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Źródło :
Thyroid : official journal of the American Thyroid Association [Thyroid] 2019 Dec; Vol. 29 (12), pp. 1843-1857. Date of Electronic Publication: 2019 Dec 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Integrin alphaVbeta3*
Mesenchymal Stem Cells/*drug effects
Thyroid Hormones/*pharmacology
Animals ; Humans ; Male ; Mice ; Microtubules/drug effects ; Neovascularization, Pathologic/pathology ; Symporters/metabolism ; Thyroxine/analogs & derivatives ; Thyroxine/pharmacology ; Triiodothyronine/pharmacology ; Tumor Microenvironment ; Vascular Endothelial Growth Factor A/metabolism ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Repurposing an anti-cancer agent for the treatment of hypertrophic heart disease.
Autorzy :
Dukinfield M; Barts Cancer Institute, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London, UK.
Maniati E; Barts Cancer Institute, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London, UK.
Reynolds LE; Barts Cancer Institute, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London, UK.
Aubdool A; William Harvey Research Institute, Queen Mary University of London, Charterhouse Square, London, UK.
Baliga RS; William Harvey Research Institute, Queen Mary University of London, Charterhouse Square, London, UK.
D'Amico G; Barts Cancer Institute, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London, UK.
Maiques O; Barts Cancer Institute, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London, UK.
Wang J; Barts Cancer Institute, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London, UK.
Bedi KC Jr; Perelman School of Medicine, University of Pennsylvania, Translational Research Center, Philadelphia, PA, USA.
Margulies KB; Perelman School of Medicine, University of Pennsylvania, Translational Research Center, Philadelphia, PA, USA.
Sanz-Moreno V; Barts Cancer Institute, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London, UK.
Hobbs A; William Harvey Research Institute, Queen Mary University of London, Charterhouse Square, London, UK.
Hodivala-Dilke K; Barts Cancer Institute, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London, UK.
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Źródło :
The Journal of pathology [J Pathol] 2019 Dec; Vol. 249 (4), pp. 523-535. Date of Electronic Publication: 2019 Oct 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Repositioning*
Cardiomegaly/*drug therapy
Cardiovascular Agents/*pharmacology
Heart Failure/*drug therapy
Integrin alphaVbeta3/*antagonists & inhibitors
Myocytes, Cardiac/*drug effects
Snake Venoms/*pharmacology
Angiotensin II/pharmacology ; Animals ; Cardiomegaly/genetics ; Cardiomegaly/metabolism ; Cardiomegaly/physiopathology ; Case-Control Studies ; Cells, Cultured ; Disease Models, Animal ; Fibrosis ; Gene Expression Regulation ; Heart Failure/genetics ; Heart Failure/metabolism ; Heart Failure/physiopathology ; Humans ; Integrin alphaVbeta3/metabolism ; Male ; Mice ; Myocytes, Cardiac/metabolism ; Myocytes, Cardiac/pathology ; Neovascularization, Physiologic/drug effects ; Recovery of Function ; Signal Transduction ; Transcriptome
Czasopismo naukowe
Tytuł :
Dysregulated integrin αVβ3 and CD47 signaling promotes joint inflammation, cartilage breakdown, and progression of osteoarthritis.
Autorzy :
Wang Q; Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, California, USA.; Veterans Affairs Palo Alto Health Care System, Palo Alto, California, USA.
Onuma K; Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, California, USA.; Veterans Affairs Palo Alto Health Care System, Palo Alto, California, USA.
Liu C; Molecular Imaging Program at Stanford (MIPS), Canary Center at Stanford for Cancer Early Detection, Department of Radiology and Bio-X Program, Stanford University School of Medicine, Stanford, California, USA.
Wong H; Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, California, USA.; Veterans Affairs Palo Alto Health Care System, Palo Alto, California, USA.
Bloom MS; Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, California, USA.; Veterans Affairs Palo Alto Health Care System, Palo Alto, California, USA.
Elliott EE; Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, California, USA.; Veterans Affairs Palo Alto Health Care System, Palo Alto, California, USA.
Cao RR; Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, California, USA.; Veterans Affairs Palo Alto Health Care System, Palo Alto, California, USA.
Hu N; Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, California, USA.; Veterans Affairs Palo Alto Health Care System, Palo Alto, California, USA.
Lingampalli N; Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, California, USA.; Veterans Affairs Palo Alto Health Care System, Palo Alto, California, USA.
Sharpe O; Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, California, USA.; Veterans Affairs Palo Alto Health Care System, Palo Alto, California, USA.
Zhao X; Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, California, USA.; Veterans Affairs Palo Alto Health Care System, Palo Alto, California, USA.
Sohn DH; Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, California, USA.; Veterans Affairs Palo Alto Health Care System, Palo Alto, California, USA.; Department of Microbiology and Immunology, Pusan National University School of Medicine, Yangsan, Gyeongsangnam-do, South Korea.
Lepus CM; Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, California, USA.; Veterans Affairs Palo Alto Health Care System, Palo Alto, California, USA.
Sokolove J; Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, California, USA.; Veterans Affairs Palo Alto Health Care System, Palo Alto, California, USA.
Mao R; Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, California, USA.; Veterans Affairs Palo Alto Health Care System, Palo Alto, California, USA.
Cisar CT; Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, California, USA.; Veterans Affairs Palo Alto Health Care System, Palo Alto, California, USA.
Raghu H; Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, California, USA.; Veterans Affairs Palo Alto Health Care System, Palo Alto, California, USA.
Chu CR; Veterans Affairs Palo Alto Health Care System, Palo Alto, California, USA.; Department of Orthopedic Surgery.
Giori NJ; Veterans Affairs Palo Alto Health Care System, Palo Alto, California, USA.; Department of Orthopedic Surgery.
Willingham SB; Institute for Stem Cell Biology and Regenerative Medicine and the Ludwig Cancer Center, and.; Departments of Pathology and Developmental Biology, Stanford University School of Medicine, Stanford, California, USA.
Prohaska SS; Institute for Stem Cell Biology and Regenerative Medicine and the Ludwig Cancer Center, and.; Departments of Pathology and Developmental Biology, Stanford University School of Medicine, Stanford, California, USA.
Cheng Z; Molecular Imaging Program at Stanford (MIPS), Canary Center at Stanford for Cancer Early Detection, Department of Radiology and Bio-X Program, Stanford University School of Medicine, Stanford, California, USA.
Weissman IL; Institute for Stem Cell Biology and Regenerative Medicine and the Ludwig Cancer Center, and.; Departments of Pathology and Developmental Biology, Stanford University School of Medicine, Stanford, California, USA.
Robinson WH; Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, California, USA.; Veterans Affairs Palo Alto Health Care System, Palo Alto, California, USA.
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Źródło :
JCI insight [JCI Insight] 2019 Sep 19; Vol. 4 (18). Date of Electronic Publication: 2019 Sep 19.
Typ publikacji :
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
CD47 Antigen/*metabolism
Cartilage, Articular/*pathology
Integrin alphaVbeta3/*metabolism
Osteoarthritis/*immunology
Signal Transduction/*immunology
Animals ; CD47 Antigen/genetics ; CD47 Antigen/immunology ; Cartilage, Articular/cytology ; Cartilage, Articular/diagnostic imaging ; Cartilage, Articular/immunology ; Cells, Cultured ; Chondrocytes ; Datasets as Topic ; Disease Models, Animal ; Disease Progression ; Gene Expression Profiling ; Humans ; Integrin alphaVbeta3/genetics ; Integrin alphaVbeta3/immunology ; Male ; Mice ; Osteoarthritis/diagnostic imaging ; Osteoarthritis/pathology ; Positron Emission Tomography Computed Tomography ; Primary Cell Culture ; Proteomics ; Synovial Membrane/cytology ; Synovial Membrane/immunology ; Synovial Membrane/pathology ; Synoviocytes ; X-Ray Microtomography
Czasopismo naukowe
Tytuł :
Structural Basis of the Differential Binding of Engineered Knottins to Integrins αVβ3 and α5β1.
Autorzy :
Van Agthoven JF; Leukocyte Biology and Inflammation Program, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA; Structural Biology Program, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA; Division of Nephrology/Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.
Shams H; Departments of Bioengineering and Mechanical Engineering, University of California, Berkeley, CA 94720, USA.
Cochran FV; Departments of Bioengineering and Chemical Engineering, Stanford University, Stanford, CA 94305, USA.
Alonso JL; Leukocyte Biology and Inflammation Program, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA; Structural Biology Program, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA; Division of Nephrology/Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.
Kintzing JR; Departments of Bioengineering and Chemical Engineering, Stanford University, Stanford, CA 94305, USA.
Garakani K; Departments of Bioengineering and Mechanical Engineering, University of California, Berkeley, CA 94720, USA.
Adair BD; Leukocyte Biology and Inflammation Program, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA; Structural Biology Program, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA; Division of Nephrology/Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.
Xiong JP; Leukocyte Biology and Inflammation Program, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA; Structural Biology Program, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA; Division of Nephrology/Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.
Mofrad MRK; Departments of Bioengineering and Mechanical Engineering, University of California, Berkeley, CA 94720, USA.
Cochran JR; Departments of Bioengineering and Chemical Engineering, Stanford University, Stanford, CA 94305, USA.
Arnaout MA; Leukocyte Biology and Inflammation Program, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA; Structural Biology Program, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA; Division of Nephrology/Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA. Electronic address: .
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Źródło :
Structure (London, England : 1993) [Structure] 2019 Sep 03; Vol. 27 (9), pp. 1443-1451.e6. Date of Electronic Publication: 2019 Jul 25.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Cystine-Knot Miniproteins/*metabolism
Integrin alphaVbeta3/*chemistry
Integrin alphaVbeta3/*metabolism
Receptors, Vitronectin/*chemistry
Receptors, Vitronectin/*metabolism
Binding Sites ; Humans ; Integrin alphaVbeta3/genetics ; K562 Cells ; Models, Molecular ; Molecular Dynamics Simulation ; Mutation ; Protein Binding ; Protein Conformation ; Receptors, Vitronectin/genetics
Czasopismo naukowe

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