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Tytuł:
Novel prognostic marker TGFBI affects the migration and invasion function of ovarian cancer cells and activates the integrin αvβ3-PI3K-Akt signaling pathway.
Autorzy:
Wang H; School of Medical Technology, Xuzhou Medical University, Xuzhou, Jiangsu, China.; Xuzhou Key Laboratory of Laboratory Diagnostics, Xuzhou Medical University, Xuzhou, Jiangsu, China.
Xu YH; Department of Laboratory Medicine, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China. .; School of Medical Technology, Xuzhou Medical University, Xuzhou, Jiangsu, 221004, China. .
Guo Y; Department of Laboratory Medicine, The Second Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China. .; Department of Laboratory Medicine, The Second Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, 221006, China. .
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Źródło:
Journal of ovarian research [J Ovarian Res] 2024 Feb 23; Vol. 17 (1), pp. 50. Date of Electronic Publication: 2024 Feb 23.
Typ publikacji:
Journal Article
MeSH Terms:
Integrin alphaVbeta3*
Ovarian Neoplasms*/genetics
Ovarian Neoplasms*/metabolism
Ovarian Neoplasms*/pathology
Transforming Growth Factor beta*/metabolism
Female ; Humans ; Extracellular Matrix Proteins/metabolism ; Molecular Docking Simulation ; Phosphatidylinositol 3-Kinases/metabolism ; Prognosis ; Proteomics ; Proto-Oncogene Proteins c-akt/metabolism ; Signal Transduction
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
FGF9, a Potent Mitogen, Is a New Ligand for Integrin αvβ3, and the FGF9 Mutant Defective in Integrin Binding Acts as an Antagonist.
Autorzy:
Chang CC; Department of Dermatology, University of California, Davis School of Medicine, Sacramento, CA 95817, USA.; Department of Biochemistry and Molecular Medicine, University of California, Davis School of Medicine, Sacramento, CA 95817, USA.
Takada YK; Department of Dermatology, University of California, Davis School of Medicine, Sacramento, CA 95817, USA.
Cheng CW; Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.
Maekawa Y; Department of Medical Technology, Faculty of Health Science, Morinomiya University of Medical Sciences, Osaka 536-0025, Japan.
Mori S; Department of Medical Technology, Faculty of Health Science, Morinomiya University of Medical Sciences, Osaka 536-0025, Japan.; Department of Molecular Pathology, Division of Health Sciences, Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan.
Takada Y; Department of Dermatology, University of California, Davis School of Medicine, Sacramento, CA 95817, USA.; Department of Biochemistry and Molecular Medicine, University of California, Davis School of Medicine, Sacramento, CA 95817, USA.
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Źródło:
Cells [Cells] 2024 Feb 07; Vol. 13 (4). Date of Electronic Publication: 2024 Feb 07.
Typ publikacji:
Journal Article
MeSH Terms:
Integrin alphaVbeta3*/metabolism
Mitogens*
Ligands ; Fibroblast Growth Factor 1 ; Fibroblast Growth Factor 2 ; DNA
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Molecular basis for the recognition of 24-(S)-hydroxycholesterol by integrin αvβ3.
Autorzy:
Gc JB; Department of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, WA, 992020, USA.
Chen J; Department of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, WA, 992020, USA.
Pokharel SM; Department of Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University, Pullman, WA, 99210, USA.
Mohanty I; Department of Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University, Pullman, WA, 99210, USA.
Mariasoosai C; Department of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, WA, 992020, USA.
Obi P; Department of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, WA, 992020, USA.
Panipinto P; Department of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, WA, 992020, USA.
Bandyopadhyay S; Molecular Biotechnology Core Laboratory, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, 44195, USA.
Bose S; Department of Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University, Pullman, WA, 99210, USA.
Natesan S; Department of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, WA, 992020, USA. .
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Źródło:
Scientific reports [Sci Rep] 2023 Jun 06; Vol. 13 (1), pp. 9166. Date of Electronic Publication: 2023 Jun 06.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Integrin alphaVbeta3*/chemistry
Integrin alphaVbeta3*/metabolism
Hydroxycholesterols*/chemistry
Hydroxycholesterols*/metabolism
Computer Simulation ; Humans ; Inflammation/metabolism ; Signal Transduction ; Macrophages/metabolism ; Models, Molecular ; Thermodynamics ; Protein Conformation ; Surface Plasmon Resonance ; Cholesterol 24-Hydroxylase/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
RGD Peptidomimetic MMAE-Conjugate Addressing Integrin αVβ3-Expressing Cells with High Targeting Index.
Autorzy:
Paulus J; Organic and Bioorganic Chemistry, Faculty of Chemistry, Bielefeld University, Universitätsstraße 25, 33615, Bielefeld, Germany.
Nachtigall B; Organic and Bioorganic Chemistry, Faculty of Chemistry, Bielefeld University, Universitätsstraße 25, 33615, Bielefeld, Germany.
Meyer P; Organic and Bioorganic Chemistry, Faculty of Chemistry, Bielefeld University, Universitätsstraße 25, 33615, Bielefeld, Germany.
Sewald N; Organic and Bioorganic Chemistry, Faculty of Chemistry, Bielefeld University, Universitätsstraße 25, 33615, Bielefeld, Germany.
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Źródło:
Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2023 Feb 24; Vol. 29 (12), pp. e202203476. Date of Electronic Publication: 2023 Jan 24.
Typ publikacji:
Journal Article
MeSH Terms:
Integrin alphaVbeta3*/chemistry
Peptidomimetics*/chemistry
Oligopeptides/chemistry
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Pro-Inflammatory Chemokines CCL5, CXCL12, and CX3CL1 Bind to and Activate Platelet Integrin αIIbβ3 in an Allosteric Manner.
Autorzy:
Takada YK; Department of Dermatology, School of Medicine, University of California-Davis, 4645 Second Ave., Research III Suite 3300, Sacramento, CA 95817, USA.; Department of Biochemistry and Molecular Medicine, University of California Davis School of Medicine, Sacramento, CA 95817, USA.
Fujita M; Department of Dermatology, School of Medicine, University of California-Davis, 4645 Second Ave., Research III Suite 3300, Sacramento, CA 95817, USA.
Takada Y; Department of Dermatology, School of Medicine, University of California-Davis, 4645 Second Ave., Research III Suite 3300, Sacramento, CA 95817, USA.; Department of Biochemistry and Molecular Medicine, University of California Davis School of Medicine, Sacramento, CA 95817, USA.
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Źródło:
Cells [Cells] 2022 Sep 29; Vol. 11 (19). Date of Electronic Publication: 2022 Sep 29.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
MeSH Terms:
Integrin alphaVbeta3*/metabolism
Platelet Glycoprotein GPIIb-IIIa Complex*/metabolism
Animals ; Chemokine CCL5 ; Cricetinae ; Cricetulus ; Endothelial Cells/metabolism ; Inflammation ; Ligands ; Proteoglycans ; Receptors, Chemokine
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
High-Resolution Conformational Analysis of RGDechi-Derived Peptides Based on a Combination of NMR Spectroscopy and MD Simulations.
Autorzy:
Acconcia C; Department of Environmental, Biological and Pharmaceutical Science and Technology, University of Campania-Luigi Vanvitelli, Via Vivaldi 43, 81100 Caserta, Italy.
Paladino A; Institute of Biostructures and Bioimaging, CNR, Via Castellino 101, 80131 Naples, Italy.
Valle MD; Department of Environmental, Biological and Pharmaceutical Science and Technology, University of Campania-Luigi Vanvitelli, Via Vivaldi 43, 81100 Caserta, Italy.
Farina B; Institute of Biostructures and Bioimaging, CNR, Via Castellino 101, 80131 Naples, Italy.; Advanced Accelerator Applications, A Novartis Company, Via Ribes, 510010 Colleretto Giacosa, Italy.
Del Gatto A; Institute of Biostructures and Bioimaging, CNR, Via Castellino 101, 80131 Naples, Italy.; Interdepartmental Center of Bioactive Peptide, University of Naples Federico II, Via Mezzocannone 16, 80134 Naples, Italy.
Gaetano SD; Institute of Biostructures and Bioimaging, CNR, Via Castellino 101, 80131 Naples, Italy.; Interdepartmental Center of Bioactive Peptide, University of Naples Federico II, Via Mezzocannone 16, 80134 Naples, Italy.
Capasso D; Interdepartmental Center of Bioactive Peptide, University of Naples Federico II, Via Mezzocannone 16, 80134 Naples, Italy.; Center for Life Sciences and Technologies (CESTEV), University of Naples Federico II, Via De Amicis 95, 80145 Naples, Italy.
Gentile MT; Department of Environmental, Biological and Pharmaceutical Science and Technology, University of Campania-Luigi Vanvitelli, Via Vivaldi 43, 81100 Caserta, Italy.
Malgieri G; Department of Environmental, Biological and Pharmaceutical Science and Technology, University of Campania-Luigi Vanvitelli, Via Vivaldi 43, 81100 Caserta, Italy.
Isernia C; Department of Environmental, Biological and Pharmaceutical Science and Technology, University of Campania-Luigi Vanvitelli, Via Vivaldi 43, 81100 Caserta, Italy.
Saviano M; Institute of Crystallography, CNR, URT Caserta, Via Vivaldi 43, 81100 Caserta, Italy.
Fattorusso R; Department of Environmental, Biological and Pharmaceutical Science and Technology, University of Campania-Luigi Vanvitelli, Via Vivaldi 43, 81100 Caserta, Italy.
Zaccaro L; Institute of Biostructures and Bioimaging, CNR, Via Castellino 101, 80131 Naples, Italy.; Interdepartmental Center of Bioactive Peptide, University of Naples Federico II, Via Mezzocannone 16, 80134 Naples, Italy.
Russo L; Department of Environmental, Biological and Pharmaceutical Science and Technology, University of Campania-Luigi Vanvitelli, Via Vivaldi 43, 81100 Caserta, Italy.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Sep 20; Vol. 23 (19). Date of Electronic Publication: 2022 Sep 20.
Typ publikacji:
Journal Article
MeSH Terms:
Integrin alphaVbeta3*/metabolism
Peptides*/chemistry
Magnetic Resonance Spectroscopy ; Oligopeptides/chemistry ; Pharmaceutical Preparations
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Extracellular matrix derived from Wharton's Jelly-derived mesenchymal stem cells promotes angiogenesis via integrin αVβ3/c-Myc/P300/VEGF.
Autorzy:
Ma B; Department of Clinical Laboratory, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250012, Shandong, China.
Wang T; Department of Gastroenterology, Qilu Hospital of Shandong University, Jinan, 250012, Shandong, China.
Li J; Department of Clinical Laboratory, Qilu Hospital of Shandong University (Qingdao), Qingdao, 266035, China.
Wang Q; Department of Clinical Laboratory, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250012, Shandong, China. .
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Źródło:
Stem cell research & therapy [Stem Cell Res Ther] 2022 Jul 18; Vol. 13 (1), pp. 327. Date of Electronic Publication: 2022 Jul 18.
Typ publikacji:
Journal Article
MeSH Terms:
E1A-Associated p300 Protein*/metabolism
Integrin alphaVbeta3*/metabolism
Mesenchymal Stem Cells*/cytology
Mesenchymal Stem Cells*/metabolism
Vascular Endothelial Growth Factor A*/metabolism
Wharton Jelly*/cytology
Wharton Jelly*/metabolism
Cell Differentiation ; Cell Proliferation ; Cells, Cultured ; Extracellular Matrix/metabolism ; Human Umbilical Vein Endothelial Cells/cytology ; Human Umbilical Vein Endothelial Cells/metabolism ; Humans ; Neovascularization, Physiologic ; Proto-Oncogene Proteins c-myc/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Deletion of TRIB3 disrupts the tumor progression induced by integrin αvβ3 in lung cancer.
Autorzy:
Zhou W; Department of Lung Cancer Surgery, Tianjin Medical University General Hospital, No.154 Anshan Road, Heping District, Tianjin City, 300052, China.; Department of Thoracic Surgery, Shanxi Provincial People's Hospital, Taiyuan, China.
Ma J; Department of Thoracic Surgery, Shanxi Provincial People's Hospital, Taiyuan, China.
Meng L; Department of Thoracic Surgery, Shanxi Provincial People's Hospital, Taiyuan, China.
Liu D; Department of Thoracic Surgery, Shanxi Provincial People's Hospital, Taiyuan, China.
Chen J; Department of Lung Cancer Surgery, Tianjin Medical University General Hospital, No.154 Anshan Road, Heping District, Tianjin City, 300052, China. .
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Źródło:
BMC cancer [BMC Cancer] 2022 Apr 26; Vol. 22 (1), pp. 459. Date of Electronic Publication: 2022 Apr 26.
Typ publikacji:
Journal Article
MeSH Terms:
Cell Cycle Proteins*/genetics
Cell Cycle Proteins*/metabolism
Integrin alphaVbeta3*/genetics
Integrin alphaVbeta3*/metabolism
Lung Neoplasms*/pathology
Protein Serine-Threonine Kinases*/antagonists & inhibitors
Protein Serine-Threonine Kinases*/genetics
Protein Serine-Threonine Kinases*/metabolism
Repressor Proteins*/genetics
Repressor Proteins*/metabolism
Animals ; Cell Proliferation/genetics ; Humans ; Mice ; Proto-Oncogene Proteins c-akt/metabolism ; Signal Transduction
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Regulation of the integrin αVβ3- actin filaments axis in early osteogenic differentiation of human mesenchymal stem cells under cyclic tensile stress.
Autorzy:
Peng Y; Guangdong Provincial Key Laboratory of Medical Biomechanics and Guangdong Engineering Research Center for Translation of Medical 3D Printing Application and National Virtual and Reality Experimental Education Center for Medical Morphology and National Key Discipline of Human Anatomy, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, China.
Qu R; Guangdong Provincial Key Laboratory of Medical Biomechanics and Guangdong Engineering Research Center for Translation of Medical 3D Printing Application and National Virtual and Reality Experimental Education Center for Medical Morphology and National Key Discipline of Human Anatomy, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, China.
Yang Y; Guangdong Provincial Key Laboratory of Medical Biomechanics and Guangdong Engineering Research Center for Translation of Medical 3D Printing Application and National Virtual and Reality Experimental Education Center for Medical Morphology and National Key Discipline of Human Anatomy, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, China.
Fan T; Guangdong Provincial Key Laboratory of Medical Biomechanics and Guangdong Engineering Research Center for Translation of Medical 3D Printing Application and National Virtual and Reality Experimental Education Center for Medical Morphology and National Key Discipline of Human Anatomy, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, China.
Sun B; Guangdong Provincial Key Laboratory of Medical Biomechanics and Guangdong Engineering Research Center for Translation of Medical 3D Printing Application and National Virtual and Reality Experimental Education Center for Medical Morphology and National Key Discipline of Human Anatomy, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, China.
Khan AU; Guangdong Provincial Key Laboratory of Medical Biomechanics and Guangdong Engineering Research Center for Translation of Medical 3D Printing Application and National Virtual and Reality Experimental Education Center for Medical Morphology and National Key Discipline of Human Anatomy, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, China.
Wu S; Guangdong Provincial Key Laboratory of Medical Biomechanics and Guangdong Engineering Research Center for Translation of Medical 3D Printing Application and National Virtual and Reality Experimental Education Center for Medical Morphology and National Key Discipline of Human Anatomy, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, China.
Liu W; Guangdong Provincial Key Laboratory of Medical Biomechanics and Guangdong Engineering Research Center for Translation of Medical 3D Printing Application and National Virtual and Reality Experimental Education Center for Medical Morphology and National Key Discipline of Human Anatomy, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, China.
Zhu J; Guangdong Provincial Key Laboratory of Medical Biomechanics and Guangdong Engineering Research Center for Translation of Medical 3D Printing Application and National Virtual and Reality Experimental Education Center for Medical Morphology and National Key Discipline of Human Anatomy, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, China.
Chen J; Shenzhen Andy New Material Technology Co., LTD, Shenzhen, 518106, China.
Li X; Shenzhen Andy New Material Technology Co., LTD, Shenzhen, 518106, China.
Dai J; Guangdong Provincial Key Laboratory of Medical Biomechanics and Guangdong Engineering Research Center for Translation of Medical 3D Printing Application and National Virtual and Reality Experimental Education Center for Medical Morphology and National Key Discipline of Human Anatomy, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, China. .
Ouyang J; Guangdong Provincial Key Laboratory of Medical Biomechanics and Guangdong Engineering Research Center for Translation of Medical 3D Printing Application and National Virtual and Reality Experimental Education Center for Medical Morphology and National Key Discipline of Human Anatomy, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, China. .
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Źródło:
Cell communication and signaling : CCS [Cell Commun Signal] 2023 Oct 30; Vol. 21 (1), pp. 308. Date of Electronic Publication: 2023 Oct 30.
Typ publikacji:
Video-Audio Media; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Mesenchymal Stem Cells*/metabolism
Osteogenesis*
Humans ; Actin Cytoskeleton/metabolism ; Cell Differentiation ; Cells, Cultured ; Core Binding Factor Alpha 1 Subunit/metabolism ; Integrin alphaVbeta3/metabolism ; Vinculin/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Inhibition of cancer-type amino acid transporter LAT1 suppresses B16-F10 melanoma metastasis in mouse models.
Autorzy:
Shi Z; Department of Bio-System Pharmacology, Graduate School of Medicine, Osaka University, 2-2, Yamadaoka, Suita, Osaka, 565-0871, Japan.
Kaneda-Nakashima K; Department of Bio-System Pharmacology, Graduate School of Medicine, Osaka University, 2-2, Yamadaoka, Suita, Osaka, 565-0871, Japan.; MS-CORE, FRC, Graduate School of Science, Osaka University, 1-1, Machikaneyama, Toyonaka, Osaka, 560-0043, Japan.; Division of Science, Institute for Radiation Sciences, Osaka University, 2-4, Yamadaoka, Suita, Osaka, 565-0871, Japan.
Ohgaki R; Department of Bio-System Pharmacology, Graduate School of Medicine, Osaka University, 2-2, Yamadaoka, Suita, Osaka, 565-0871, Japan.; Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University, Suita, Osaka, 565-0871, Japan.
Xu M; Department of Bio-System Pharmacology, Graduate School of Medicine, Osaka University, 2-2, Yamadaoka, Suita, Osaka, 565-0871, Japan.
Okanishi H; Department of Bio-System Pharmacology, Graduate School of Medicine, Osaka University, 2-2, Yamadaoka, Suita, Osaka, 565-0871, Japan.
Endou H; J-Pharma Co., Ltd, Yokohama, Kanagawa, 230-0046, Japan.
Nagamori S; Center for SI Medical Research, The Jikei University School of Medicine, 3-25-8, Nishi-Shimbashi, Minato, Tokyo, 105-8461, Japan.; Department of Laboratory Medicine, The Jikei University School of Medicine, 3-25-8, Nishi-Shimbashi, Minato, Tokyo, 105-8461, Japan.
Kanai Y; Department of Bio-System Pharmacology, Graduate School of Medicine, Osaka University, 2-2, Yamadaoka, Suita, Osaka, 565-0871, Japan. .; Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University, Suita, Osaka, 565-0871, Japan. .
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Źródło:
Scientific reports [Sci Rep] 2023 Aug 25; Vol. 13 (1), pp. 13943. Date of Electronic Publication: 2023 Aug 25.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Lung Neoplasms*/genetics
Melanoma, Experimental*/genetics
Neoplasms, Second Primary*
Animals ; Mice ; Amino Acid Transport Systems ; Disease Models, Animal ; Integrin alphaVbeta3 ; Large Neutral Amino Acid-Transporter 1/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Integrins and Actions of Androgen in Breast Cancer.
Autorzy:
Tsai CC; Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan.; Graduate Institute of Nanomedicine and Medical Engineering, College of Medical Engineering, Taipei Medical University, Taipei 11031, Taiwan.
Yang YSH; Joint Biobank, Office of Human Research, Taipei Medical University, Taipei 11031, Taiwan.
Chen YF; Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan.
Huang LY; Department of Pediatrics, E-DA Hospital, I-Shou University, Kaohsiung 82445, Taiwan.
Yang YN; Department of Pediatrics, E-DA Hospital, I-Shou University, Kaohsiung 82445, Taiwan.; School of Medicine, I-Shou University, Kaohsiung 82445, Taiwan.
Lee SY; Dentistry, Wan-Fang Medical Center, Taipei Medical University, Taipei 11031, Taiwan.; School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei 11031, Taiwan.
Wang WL; Department of Life Science, Fu Jen Catholic University, New Taipei City 242, Taiwan.
Lee HL; Department of Radiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan.; Department of Radiation Oncology, Taipei Medical University Hospital, Taipei 110, Taiwan.; The Ph.D. Program for Translational Medicine, College of Medical Science and Technology, Taipei Medical University and Academia Sinica, Taipei 11031, Taiwan.
Whang-Peng J; Cancer Center, Wan Fang Hospital, Taipei Medical University, Taipei 11031, Taiwan.
Lin HY; Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan.; Cancer Center, Wan Fang Hospital, Taipei Medical University, Taipei 11031, Taiwan.; TMU Research Center of Cancer Translational Medicine, Taipei Medical University, Taipei 11031, Taiwan.; Traditional Herbal Medicine Research Center of Taipei Medical University Hospital, Taipei Medical University, Taipei 11031, Taiwan.; Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, Albany, NY 12208, USA.
Wang K; Graduate Institute of Nanomedicine and Medical Engineering, College of Medical Engineering, Taipei Medical University, Taipei 11031, Taiwan.
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Źródło:
Cells [Cells] 2023 Aug 22; Vol. 12 (17). Date of Electronic Publication: 2023 Aug 22.
Typ publikacji:
Journal Article; Review; Research Support, Non-U.S. Gov't
MeSH Terms:
Androgens*/pharmacology
B7-H1 Antigen*
Male ; Humans ; Endothelial Cells ; Integrin alphaVbeta3 ; Cell Transformation, Neoplastic
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Human Adenovirus Type 26 Induced IL-6 Gene Expression in an αvβ3 Integrin- and NF-κB-Dependent Manner.
Autorzy:
Nestić D; Laboratory for Cell Biology and Signalling, Division of Molecular Biology, Ruđer Bošković Institute, 10000 Zagreb, Croatia.
Božinović K; Laboratory for Cell Biology and Signalling, Division of Molecular Biology, Ruđer Bošković Institute, 10000 Zagreb, Croatia.
Drašković I; Laboratory for Cell Biology and Signalling, Division of Molecular Biology, Ruđer Bošković Institute, 10000 Zagreb, Croatia.
Kovačević A; Laboratory for Cell Biology and Signalling, Division of Molecular Biology, Ruđer Bošković Institute, 10000 Zagreb, Croatia.
van den Bosch J; Laboratory for Cell Biology and Signalling, Division of Molecular Biology, Ruđer Bošković Institute, 10000 Zagreb, Croatia.
Knežević J; Laboratory for Advanced Genomics, Division of Molecular Medicine, Ruđer Bošković Institute, 10000 Zagreb, Croatia.; Faculty for Dental Medicine and Health, University of Osijek, 31000 Osijek, Croatia.
Custers J; Janssen Vaccines and Preventions BV, 2333 CA Leiden, The Netherlands.
Ambriović-Ristov A; Laboratory for Cell Biology and Signalling, Division of Molecular Biology, Ruđer Bošković Institute, 10000 Zagreb, Croatia.
Majhen D; Laboratory for Cell Biology and Signalling, Division of Molecular Biology, Ruđer Bošković Institute, 10000 Zagreb, Croatia.
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Źródło:
Viruses [Viruses] 2022 Mar 24; Vol. 14 (4). Date of Electronic Publication: 2022 Mar 24.
Typ publikacji:
Journal Article
MeSH Terms:
Adenoviruses, Human*/genetics
Adenoviruses, Human*/metabolism
Integrin alphaVbeta3*/metabolism
Interleukin-6*/genetics
NF-kappa B*/metabolism
Cells, Cultured ; Chemokines/genetics ; Cytokines/genetics ; Cytokines/metabolism ; Gene Expression ; Humans
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Combined integrin α v β 3 and lactoferrin receptor targeted docetaxel liposomes enhance the brain targeting effect and anti-glioma effect.
Autorzy:
Qi N; Cancer Center, Integrated Hospital of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510315, China.; Department of Pharmacy, Guilin Medical University, Guilin, 541004, China.
Zhang S; Department of Pharmacy, Guilin Medical University, Guilin, 541004, China.
Zhou X; Department of Pharmacy, Guilin Medical University, Guilin, 541004, China.
Duan W; Department of Pharmacy, Guilin Medical University, Guilin, 541004, China.
Gao D; Department of Pharmacy, Guilin Medical University, Guilin, 541004, China.
Feng J; Department of Pharmacy, Guangxi University of Chinese Medicine, Nanning, 530299, China.
Li A; Cancer Center, Integrated Hospital of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510315, China. .
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Źródło:
Journal of nanobiotechnology [J Nanobiotechnology] 2021 Dec 23; Vol. 19 (1), pp. 446. Date of Electronic Publication: 2021 Dec 23.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents/*pharmacology
Docetaxel/*chemistry
Integrin alphaVbeta3/*antagonists & inhibitors
Liposomes/*chemistry
Receptors, Cell Surface/*antagonists & inhibitors
Animals ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/metabolism ; Antineoplastic Agents/therapeutic use ; Brain Neoplasms/diagnostic imaging ; Brain Neoplasms/drug therapy ; Brain Neoplasms/pathology ; Cell Line, Tumor ; Cell Survival/drug effects ; Docetaxel/metabolism ; Docetaxel/pharmacology ; Docetaxel/therapeutic use ; Glioma/diagnostic imaging ; Glioma/drug therapy ; Glioma/pathology ; Humans ; Integrin alphaVbeta3/metabolism ; Liposomes/pharmacokinetics ; Mice ; Mice, Nude ; Oligopeptides/chemistry ; Particle Size ; Receptors, Cell Surface/metabolism ; Survival Rate ; Tissue Distribution
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
αVβ3 Integrin Expression Is Essential for Replication of Mosquito and Tick-Borne Flaviviruses in Murine Fibroblast Cells.
Autorzy:
Reis VPD; Institute of Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Südufer 10, 17493 Greifswald-Insel Riems, Germany.; Institute for Virology, Philipps University Marburg, Hans-Meerwein-Straße 2, 35043 Marburg, Germany.
Keller M; Institute of Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Südufer 10, 17493 Greifswald-Insel Riems, Germany.
Schmidt K; Microbiological Diagnostics, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.
Ulrich RG; Institute of Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Südufer 10, 17493 Greifswald-Insel Riems, Germany.; Deutsches Zentrum für Infektionsforschung(DZIF), Partner Site Hamburg-Lübeck-Borstel-Riems, Südufer 10, 17493 Greifswald-Insel Riems, Germany.
Groschup MH; Institute of Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Südufer 10, 17493 Greifswald-Insel Riems, Germany.; Deutsches Zentrum für Infektionsforschung(DZIF), Partner Site Hamburg-Lübeck-Borstel-Riems, Südufer 10, 17493 Greifswald-Insel Riems, Germany.
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Źródło:
Viruses [Viruses] 2021 Dec 23; Vol. 14 (1). Date of Electronic Publication: 2021 Dec 23.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Virus Replication*
Flavivirus/*physiology
Integrin alphaVbeta3/*metabolism
Animals ; Cell Line ; Encephalitis Viruses, Tick-Borne/genetics ; Encephalitis Viruses, Tick-Borne/physiology ; Fibroblasts/virology ; Flavivirus/genetics ; Genome, Viral ; Integrin alphaVbeta3/genetics ; Mice ; RNA, Viral/genetics ; RNA, Viral/metabolism ; Virus Attachment ; Virus Internalization ; West Nile virus/genetics ; West Nile virus/physiology ; Yellow fever virus/genetics ; Yellow fever virus/physiology
SCR Organism:
Usutu virus
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
CCL4 Stimulates Cell Migration in Human Osteosarcoma via the mir-3927-3p/Integrin αvβ3 Axis.
Autorzy:
Tsai HC; School of Medicine, China Medical University, Taichung 404022, Taiwan.; Division of Hematology and Oncology, Department of Internal Medicine, China Medical University Hospital, Taichung 404332, Taiwan.
Lai YY; School of Chinese Medicine, China Medical University, Taichung 406040, Taiwan.
Hsu HC; Department of Medical Research, Chung Shan Medical University, Taichung 40201, Taiwan.
Fong YC; Department of Sports Medicine, College of Health Care, China Medical University, Taichung 404022, Taiwan.; Department of Orthopedic Surgery, China Medical University Beigang Hospital, Yunlin 651012, Taiwan.
Lien MY; School of Medicine, China Medical University, Taichung 404022, Taiwan.; Division of Hematology and Oncology, Department of Internal Medicine, China Medical University Hospital, Taichung 404332, Taiwan.
Tang CH; School of Medicine, China Medical University, Taichung 404022, Taiwan.; Graduate Institute of Basic Medical Science, China Medical University, Taichung 404022, Taiwan.; Graduate Institute of Biomedical Sciences, China Medical University, Taichung 404022, Taiwan.; Chinese Medicine Research Center, China Medical University, Taichung 404022, Taiwan.; Department of Biotechnology, College of Health Science, Asia University, Taichung 41354, Taiwan.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Nov 25; Vol. 22 (23). Date of Electronic Publication: 2021 Nov 25.
Typ publikacji:
Journal Article
MeSH Terms:
Cell Movement*
Gene Expression Regulation, Neoplastic*
Biomarkers, Tumor/*metabolism
Chemokine CCL4/*metabolism
Integrin alphaVbeta3/*metabolism
MicroRNAs/*genetics
Osteosarcoma/*pathology
Apoptosis ; Biomarkers, Tumor/genetics ; Bone Neoplasms/genetics ; Bone Neoplasms/metabolism ; Bone Neoplasms/pathology ; Cell Proliferation ; Chemokine CCL4/genetics ; Humans ; Integrin alphaVbeta3/genetics ; Osteosarcoma/genetics ; Osteosarcoma/metabolism ; Tumor Cells, Cultured
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Regulation of the integrin αVβ3- actin filaments axis in early osteogenesis of human fibroblasts under cyclic tensile stress.
Autorzy:
Peng Y; Guangdong Provincial Key Laboratory of Medical Biomechanics and Department of Anatomy, School of Basic Medical Science, Southern Medical University, Guangzhou, 510000, China.
Qu R; Guangdong Provincial Key Laboratory of Medical Biomechanics and Department of Anatomy, School of Basic Medical Science, Southern Medical University, Guangzhou, 510000, China.
Feng Y; Department of Ophthalmology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510000, Guangdong, China.
Huang X; Guangdong Provincial Key Laboratory of Medical Biomechanics and Department of Anatomy, School of Basic Medical Science, Southern Medical University, Guangzhou, 510000, China.
Yang Y; Guangdong Provincial Key Laboratory of Medical Biomechanics and Department of Anatomy, School of Basic Medical Science, Southern Medical University, Guangzhou, 510000, China.
Fan T; Guangdong Provincial Key Laboratory of Medical Biomechanics and Department of Anatomy, School of Basic Medical Science, Southern Medical University, Guangzhou, 510000, China.
Sun B; Guangdong Provincial Key Laboratory of Medical Biomechanics and Department of Anatomy, School of Basic Medical Science, Southern Medical University, Guangzhou, 510000, China.
Khan AU; Guangdong Provincial Key Laboratory of Medical Biomechanics and Department of Anatomy, School of Basic Medical Science, Southern Medical University, Guangzhou, 510000, China.
Wu S; Guangdong Provincial Key Laboratory of Medical Biomechanics and Department of Anatomy, School of Basic Medical Science, Southern Medical University, Guangzhou, 510000, China.
Dai J; Guangdong Provincial Key Laboratory of Medical Biomechanics and Department of Anatomy, School of Basic Medical Science, Southern Medical University, Guangzhou, 510000, China. .
Ouyang J; Guangdong Provincial Key Laboratory of Medical Biomechanics and Department of Anatomy, School of Basic Medical Science, Southern Medical University, Guangzhou, 510000, China. .
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Źródło:
Stem cell research & therapy [Stem Cell Res Ther] 2021 Oct 07; Vol. 12 (1), pp. 523. Date of Electronic Publication: 2021 Oct 07.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Integrin alphaVbeta3*
Osteogenesis*
Fibroblasts/*cytology
Actin Cytoskeleton ; Cells, Cultured ; Humans ; Stress, Mechanical
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Dual integrin αvβ3 and αvβ5 blockade attenuates cardiac dysfunction by reducing fibrosis in a rat model of doxorubicin-induced cardiomyopathy.
Autorzy:
Sui S; Department of Radiology, Shengjing Hospital of China Medical University, Shenyang, China.
Hou Y; Department of Radiology, Shengjing Hospital of China Medical University, Shenyang, China.
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Źródło:
Scandinavian cardiovascular journal : SCJ [Scand Cardiovasc J] 2021 Oct; Vol. 55 (5), pp. 287-296. Date of Electronic Publication: 2021 Jul 23.
Typ publikacji:
Journal Article
MeSH Terms:
Cardiomyopathies*/chemically induced
Cardiomyopathies*/epidemiology
Integrin alphaVbeta3*/antagonists & inhibitors
Receptors, Vitronectin*/antagonists & inhibitors
Animals ; Disease Models, Animal ; Doxorubicin/toxicity ; Fibrosis/prevention & control ; Male ; Rats
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Gallium-68 labelled RGD PET/CT imaging of endothelial activation in COVID-19 patients.
Autorzy:
van Genugten EAJ; Department of Medical Imaging, Radboud University Medical Center, Geert Grooteplein Zuid 10, 6525GA, Nijmegen, The Netherlands.
van Lith TJ; Department of Neurology, Donders Center for Medical Neurosciences, Radboud University Medical Center, Nijmegen, The Netherlands.
van den Heuvel FMA; Department of Cardiology, Radboud University Medical Center, Nijmegen, The Netherlands.
van Steenis JL; Department of Medical Imaging, Radboud University Medical Center, Geert Grooteplein Zuid 10, 6525GA, Nijmegen, The Netherlands.; Faculty of Science and Technology, University of Twente, Enschede, The Netherlands.
Ten Heggeler RM; Department of Medical Imaging, Radboud University Medical Center, Geert Grooteplein Zuid 10, 6525GA, Nijmegen, The Netherlands.; Faculty of Science and Technology, University of Twente, Enschede, The Netherlands.
Brink M; Department of Medical Imaging, Radboud University Medical Center, Geert Grooteplein Zuid 10, 6525GA, Nijmegen, The Netherlands.
Rodwell L; Department of Health Evidence, Section Biostatistics, Radboud University Medical Center, Nijmegen, The Netherlands.
Meijer FJA; Department of Medical Imaging, Radboud University Medical Center, Geert Grooteplein Zuid 10, 6525GA, Nijmegen, The Netherlands.
Lobeek D; Department of Medical Imaging, Radboud University Medical Center, Geert Grooteplein Zuid 10, 6525GA, Nijmegen, The Netherlands.
Hagmolen Of Ten Have W; Department of Respiratory Diseases, Radboud University Medical Center, Nijmegen, The Netherlands.
van de Veerdonk FL; Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.
Netea MG; Department of Respiratory Diseases, Radboud University Medical Center, Nijmegen, The Netherlands.; Department of Immunology and Metabolism, Life and Medical Sciences Institute, University of Bonn, Bonn, Germany.
Prokop M; Department of Medical Imaging, Radboud University Medical Center, Geert Grooteplein Zuid 10, 6525GA, Nijmegen, The Netherlands.
Nijveldt R; Department of Cardiology, Radboud University Medical Center, Nijmegen, The Netherlands.
Tuladhar AM; Department of Neurology, Donders Center for Medical Neurosciences, Radboud University Medical Center, Nijmegen, The Netherlands.
Aarntzen EHJG; Department of Medical Imaging, Radboud University Medical Center, Geert Grooteplein Zuid 10, 6525GA, Nijmegen, The Netherlands. .
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Źródło:
Scientific reports [Sci Rep] 2023 Jul 17; Vol. 13 (1), pp. 11507. Date of Electronic Publication: 2023 Jul 17.
Typ publikacji:
Observational Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Positron Emission Tomography Computed Tomography*
COVID-19*/diagnostic imaging
Humans ; Middle Aged ; Aged ; Gallium Radioisotopes ; Endothelial Cells/metabolism ; Positron-Emission Tomography ; Oligopeptides ; Integrin alphaVbeta3/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Design, Synthesis and Anti-Melanoma Activity of Novel Annexin V Derivative with β 3 -Integrin Affinity.
Autorzy:
Zhu J; Beijing Key Lab of Biotechnology and Genetic Engineering, College of Life Sciences, Beijing Normal University, Beijing 100875, China.
Li W; Beijing Key Lab of Biotechnology and Genetic Engineering, College of Life Sciences, Beijing Normal University, Beijing 100875, China.
Jing J; Beijing Key Lab of Biotechnology and Genetic Engineering, College of Life Sciences, Beijing Normal University, Beijing 100875, China.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Jul 05; Vol. 24 (13). Date of Electronic Publication: 2023 Jul 05.
Typ publikacji:
Journal Article
MeSH Terms:
Integrin beta3*/metabolism
Melanoma*/metabolism
Humans ; Mice ; Animals ; Annexin A5/metabolism ; Endothelial Cells/metabolism ; Platelet Glycoprotein GPIIb-IIIa Complex/metabolism ; Integrin alphaVbeta3/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
αvβ3 Integrin as a Link between the Development of Fibrosis and Thyroid Hormones in Systemic Sclerosis.
Autorzy:
Kohon MY; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel.; Autoimmune Research Laboratory, Meir Medical Center, Kfar Saba 4428164, Israel.
Zaaroor Levy M; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel.; Autoimmune Research Laboratory, Meir Medical Center, Kfar Saba 4428164, Israel.
Hornik-Lurie T; Data Research Department, Meir Medical Center, Kfar Saba 4428164, Israel.
Shalom A; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel.; Department of Plastic Surgery, Meir Medical Center, Kfar Saba 4428164, Israel.
Berl A; Department of Plastic Surgery, Meir Medical Center, Kfar Saba 4428164, Israel.
Drucker L; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel.; Oncogenetics Laboratory, Meir Medical Center, Kfar Saba 4428164, Israel.
Levy Y; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel.; Autoimmune Research Laboratory, Meir Medical Center, Kfar Saba 4428164, Israel.; Department of Internal Medicine E, Meir Medical Center, Kfar Saba 4428164, Israel.
Tartakover Matalon S; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel.; Autoimmune Research Laboratory, Meir Medical Center, Kfar Saba 4428164, Israel.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 May 18; Vol. 24 (10). Date of Electronic Publication: 2023 May 18.
Typ publikacji:
Journal Article
MeSH Terms:
Scleroderma, Systemic*/pathology
MicroRNAs*/genetics
MicroRNAs*/metabolism
Humans ; Integrin alphaVbeta3/metabolism ; Thyroid Hormones/metabolism ; Fibrosis ; Transforming Growth Factor beta/metabolism ; Fibroblasts/metabolism ; Skin/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Vitronectin-activated αvβ3 and αvβ5 integrin signalling specifies haematopoietic fate in human pluripotent stem cells.
Autorzy:
Shen J; State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Tianjin, China.
Zhu Y; State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Tianjin, China.
Zhang S; State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Tianjin, China.
Lyu S; State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Tianjin, China.
Lyu C; Department of Hematology, the First Central Hospital of Tianjin, Tianjin, China.
Feng Z; Center of Reproductive Medicine, Tianjin Central Hospital of Gynaecology and Obstetrics, Tianjin, China.
Hoyle DL; Division of Hematology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Wang ZZ; Division of Hematology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Cheng T; State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Tianjin, China.; Department of Stem Cell and Regenerative Medicine, Peking Union Medical College, Tianjin, China.; Tianjin Key Laboratory of Blood Cell Therapy and Technology, Tianjin, China.
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Źródło:
Cell proliferation [Cell Prolif] 2021 Apr; Vol. 54 (4), pp. e13012. Date of Electronic Publication: 2021 Mar 03.
Typ publikacji:
Journal Article
MeSH Terms:
Cell Differentiation/*drug effects
Integrin alphaVbeta3/*metabolism
Receptors, Vitronectin/*metabolism
Vitronectin/*pharmacology
Cell Adhesion/drug effects ; Cell Line ; Gene Expression Regulation ; Hematopoietic Stem Cells/cytology ; Hematopoietic Stem Cells/metabolism ; Homeodomain Proteins/genetics ; Homeodomain Proteins/metabolism ; Humans ; Integrin alphaVbeta3/antagonists & inhibitors ; Integrin alphaVbeta3/genetics ; Mesoderm/cytology ; Mesoderm/growth & development ; Mesoderm/metabolism ; Pluripotent Stem Cells/cytology ; Pluripotent Stem Cells/metabolism ; RNA Interference ; RNA, Small Interfering/metabolism ; Receptors, Vitronectin/antagonists & inhibitors ; Receptors, Vitronectin/genetics ; Signal Transduction/drug effects ; Snake Venoms/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
SARS-CoV-2 uses major endothelial integrin αvβ3 to cause vascular dysregulation in-vitro during COVID-19.
Autorzy:
Nader D; Cardiovascular Infection Research Group, School of Pharmacy and Biomolecular Sciences, RCSI University of Medicine and Health Sciences, Royal College of Surgeons in Ireland, Dublin 2, Ireland.
Fletcher N; School of Veterinary Medicine, Veterinary Science Centre, University College Dublin, Belfield, Dublin 4, Ireland.
Curley GF; Department of Anaesthesia and Critical Care Medicine, RCSI University of Medicine and Health Sciences, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland.
Kerrigan SW; Cardiovascular Infection Research Group, School of Pharmacy and Biomolecular Sciences, RCSI University of Medicine and Health Sciences, Royal College of Surgeons in Ireland, Dublin 2, Ireland.
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Źródło:
PloS one [PLoS One] 2021 Jun 23; Vol. 16 (6), pp. e0253347. Date of Electronic Publication: 2021 Jun 23 (Print Publication: 2021).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Endothelium, Vascular/*virology
Integrin alphaVbeta3/*metabolism
SARS-CoV-2/*pathogenicity
Snake Venoms/*pharmacology
Antigens, CD/metabolism ; Binding Sites ; COVID-19/metabolism ; COVID-19/physiopathology ; Caco-2 Cells ; Cadherins/metabolism ; Computer Simulation ; Endothelium, Vascular/cytology ; Endothelium, Vascular/physiopathology ; Host-Pathogen Interactions/drug effects ; Humans ; Integrin alphaVbeta3/chemistry ; Models, Molecular ; Mutation ; Permeability ; SARS-CoV-2/drug effects ; SARS-CoV-2/genetics ; SARS-CoV-2/metabolism ; Spike Glycoprotein, Coronavirus/chemistry ; Spike Glycoprotein, Coronavirus/metabolism ; Virus Internalization
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Non-oncological applications of RGD-based single-photon emission tomography and positron emission tomography agents.
Autorzy:
Ebenhan T; Nuclear Medicine, University of Pretoria, Pretoria, 0001, South Africa. .; Nuclear Medicine Research Infrastructure, NPC, Pretoria, 0001, South Africa. .
Kleynhans J; Nuclear Medicine, University of Pretoria, Pretoria, 0001, South Africa.; Nuclear Medicine Research Infrastructure, NPC, Pretoria, 0001, South Africa.
Zeevaart JR; Nuclear Medicine Research Infrastructure, NPC, Pretoria, 0001, South Africa.; DST/NWU Preclinical Drug Development Platform, North-West University, Potchefstroom, 2520, South Africa.
Jeong JM; Department of Nuclear Medicine, Institute of Radiation Medicine, Seoul National University College of Medicine, 101 Daehangno Jongno-gu, Seoul, 110-744, South Korea.
Sathekge M; Nuclear Medicine, University of Pretoria, Pretoria, 0001, South Africa.
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Źródło:
European journal of nuclear medicine and molecular imaging [Eur J Nucl Med Mol Imaging] 2021 May; Vol. 48 (5), pp. 1414-1433. Date of Electronic Publication: 2020 Sep 12.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Integrin alphaVbeta3*
Positron-Emission Tomography*
Oligopeptides ; Tomography, Emission-Computed, Single-Photon
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
αvβ3 Integrin induces partial EMT independent of TGF-β signaling.
Autorzy:
Kariya Y; Department of Biochemistry, Fukushima Medical University School of Medicine, Fukushima City, 960-1295, Japan. .
Oyama M; Department of Biochemistry, Fukushima Medical University School of Medicine, Fukushima City, 960-1295, Japan.
Suzuki T; Laboratory Animal Research Center, Fukushima Medical University School of Medicine, Fukushima City, 960-1295, Japan.; Department of Clinical Laboratory Medicine, Fukushima Medical University Hospital, Fukushima City, 960-1295, Japan.
Kariya Y; Department of Biochemistry, Fukushima Medical University School of Medicine, Fukushima City, 960-1295, Japan.
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Źródło:
Communications biology [Commun Biol] 2021 Apr 21; Vol. 4 (1), pp. 490. Date of Electronic Publication: 2021 Apr 21.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Epithelial-Mesenchymal Transition/*genetics
Integrin alphaVbeta3/*genetics
Transforming Growth Factor beta1/*genetics
Animals ; Female ; Integrin alphaVbeta3/metabolism ; Mice ; Mice, Nude ; Transforming Growth Factor beta1/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Self-Assembly Iron Oxide Nanoclusters for Photothermal-Mediated Synergistic Chemo/Chemodynamic Therapy.
Autorzy:
Li X; Department of Neurosurgery & Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China.; Department of Neurosurgery, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu Province, China.
Wang Z; Department of Neurosurgery, The Affiliated Brain Hospital with Nanjing Medical University, Fourth Clinical College of Nanjing Medical University, Jiangsu Province, China.
Ma M; Department of Neurosurgery, Suzhou Municipal Hospital, Suzhou, Jiangsu Province, China.
Chen Z; Department of Neurosurgery & Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China.
Tang XL; Department of Neurosurgery, The Affiliated Brain Hospital with Nanjing Medical University, Fourth Clinical College of Nanjing Medical University, Jiangsu Province, China.
Wang Z; Department of Neurosurgery & Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China.
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Źródło:
Journal of immunology research [J Immunol Res] 2021 Apr 07; Vol. 2021, pp. 9958239. Date of Electronic Publication: 2021 Apr 07 (Print Publication: 2021).
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Combined Chemotherapy Protocols/*therapeutic use
Chemoradiotherapy/*methods
Glioma/*therapy
Integrin alphaVbeta3/*therapeutic use
Oligopeptides/*therapeutic use
Paclitaxel/*therapeutic use
Theranostic Nanomedicine/*methods
Animals ; Cell Growth Processes ; Cell Line, Tumor ; Drug Synergism ; Humans ; Infrared Rays ; Integrin alphaVbeta3/metabolism ; Magnetic Iron Oxide Nanoparticles/administration & dosage ; Magnetic Iron Oxide Nanoparticles/chemistry ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Oligopeptides/chemistry ; Paclitaxel/chemistry ; Rats ; Reactive Oxygen Species/metabolism ; Serum Albumin, Human/chemistry ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Wyświetlanie 1-25 z 450

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