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Tytuł :
MiR-10b-5p inhibits tumorigenesis in gastric cancer xenograft mice model through down-regulating Tiam1.
Autorzy :
Liu F; Department of Emergency, The First Hospital of Jilin University, Changchun, Jilin, China.
An X; Key Laboratory of Organ Regeneration and Transplantation of Ministry of Education, The First Hospital of Jilin University, Changchun, Jilin, China.
Zhao X; Department of Hepatology, The First Hospital of Jilin University, Changchun, Jilin, China.
Zhang N; Key Laboratory of Organ Regeneration and Transplantation of Ministry of Education, The First Hospital of Jilin University, Changchun, Jilin, China.
Chen B; Department of Emergency, The First Hospital of Jilin University, Changchun, Jilin, China.
Li Z; Key Laboratory of Organ Regeneration and Transplantation of Ministry of Education, The First Hospital of Jilin University, Changchun, Jilin, China. Electronic address: .
Xu W; Department of the Clinical Laboratory, The First Hospital of Jilin University, Changchun, Jilin, China. Electronic address: .
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Źródło :
Experimental cell research [Exp Cell Res] 2021 Oct 15; Vol. 407 (2), pp. 112810. Date of Electronic Publication: 2021 Sep 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation, Neoplastic*
Biomarkers, Tumor/*metabolism
MicroRNAs/*genetics
Stomach Neoplasms/*prevention & control
T-Lymphoma Invasion and Metastasis-inducing Protein 1/*antagonists & inhibitors
Animals ; Apoptosis ; Biomarkers, Tumor/genetics ; Cell Proliferation ; Female ; Humans ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Prognosis ; Stomach Neoplasms/genetics ; Stomach Neoplasms/metabolism ; Stomach Neoplasms/pathology ; Survival Rate ; T-Lymphoma Invasion and Metastasis-inducing Protein 1/genetics ; T-Lymphoma Invasion and Metastasis-inducing Protein 1/metabolism ; Tumor Cells, Cultured ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
T-lymphoma invasion and metastasis 1 promotes invadopodia formation and is regulated by the PI3K/Akt signaling pathway in hepatocellular carcinoma.
Autorzy :
Wang B; Institute of Hepatobiliary Surgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, 400038, China; Department of Surgery, The 63650th Troop Hospital of the Chinese People's Liberation Army, Urumqi, Xinjinag, 841700, China.
Zheng B; Institute of Hepatobiliary Surgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, 400038, China.
Cao L; Institute of Hepatobiliary Surgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, 400038, China.
Liao K; Institute of Hepatobiliary Surgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, 400038, China.
Huang D; Department of Hepatobiliary, General Hospital of Tibet Military Command Area, Lhasa, Tibet, 850000, China.
Zhang Y; Institute of Hepatobiliary Surgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, 400038, China.
Jiang Y; Institute of Hepatobiliary Surgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, 400038, China.
Zheng S; Institute of Hepatobiliary Surgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, 400038, China. Electronic address: .
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Źródło :
Experimental cell research [Exp Cell Res] 2021 Oct 15; Vol. 407 (2), pp. 112806. Date of Electronic Publication: 2021 Sep 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation, Neoplastic*
Carcinoma, Hepatocellular/*pathology
Liver Neoplasms/*pathology
Phosphatidylinositol 3-Kinases/*metabolism
Podosomes/*pathology
Proto-Oncogene Proteins c-akt/*metabolism
T-Lymphoma Invasion and Metastasis-inducing Protein 1/*metabolism
Animals ; Apoptosis ; Carcinoma, Hepatocellular/genetics ; Carcinoma, Hepatocellular/metabolism ; Cell Movement ; Cell Proliferation ; Female ; Humans ; Liver Neoplasms/genetics ; Liver Neoplasms/metabolism ; Male ; Mice ; Mice, Nude ; Middle Aged ; Phosphatidylinositol 3-Kinases/genetics ; Podosomes/metabolism ; Prognosis ; Proto-Oncogene Proteins c-akt/genetics ; Survival Rate ; T-Lymphoma Invasion and Metastasis-inducing Protein 1/genetics ; Tumor Cells, Cultured ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
The Rac-GEF Tiam1 Promotes Dendrite and Synapse Stabilization of Dentate Granule Cells and Restricts Hippocampal-Dependent Memory Functions.
Autorzy :
Cheng J; Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas 77030.; Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030.
Scala F; Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030.
Blanco FA; Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030.; Integrative Molecular and Biomedical Science Graduate Program, Baylor College of Medicine, Houston, Texas 77030.
Niu S; Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030.
Firozi K; Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030.
Keehan L; Department of Biosciences, Rice University, Houston, Texas 77005.
Mulherkar S; Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030.
Froudarakis E; Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030.
Li L; Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030.
Duman JG; Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030.
Jiang X; Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030.; Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, Texas 77030.
Tolias KF; Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas 77030 .; Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030.
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Źródło :
The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2021 Feb 10; Vol. 41 (6), pp. 1191-1206. Date of Electronic Publication: 2020 Dec 16.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Dendrites/*metabolism
Dentate Gyrus/*metabolism
Memory/*physiology
Neurogenesis/*physiology
Synapses/*metabolism
T-Lymphoma Invasion and Metastasis-inducing Protein 1/*deficiency
Animals ; Dendrites/genetics ; Dentate Gyrus/cytology ; Female ; Hippocampus/cytology ; Hippocampus/metabolism ; Male ; Mice ; Mice, 129 Strain ; Mice, Knockout ; Mice, Transgenic ; Organ Culture Techniques ; Synapses/genetics ; T-Lymphoma Invasion and Metastasis-inducing Protein 1/genetics
Czasopismo naukowe
Tytuł :
Tiam1 mediates Rac1 activation and contraction-induced glucose uptake in skeletal muscle cells.
Autorzy :
Yue Y; Department of Immunology, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Tianjin Medical University, Tianjin, China.; NHC Key Laboratory of Hormones and Development, Tianjin Medical University, Tianjin, China.; Tianjin Key Laboratory of Metabolic Diseases, Chu Hsien-I Memorial Hospital & Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin, China.; Department of Pharmacy, General Hospital, Tianjin Medical University, Tianjin, China.
Zhang C; Department of Immunology, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Tianjin Medical University, Tianjin, China.; NHC Key Laboratory of Hormones and Development, Tianjin Medical University, Tianjin, China.; Tianjin Key Laboratory of Metabolic Diseases, Chu Hsien-I Memorial Hospital & Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin, China.; Department of Pharmacy, General Hospital, Tianjin Medical University, Tianjin, China.
Zhao X; Department of Immunology, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Tianjin Medical University, Tianjin, China.; NHC Key Laboratory of Hormones and Development, Tianjin Medical University, Tianjin, China.; Tianjin Key Laboratory of Metabolic Diseases, Chu Hsien-I Memorial Hospital & Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin, China.; Department of Pharmacy, General Hospital, Tianjin Medical University, Tianjin, China.
Liu S; Department of Immunology, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Tianjin Medical University, Tianjin, China.; NHC Key Laboratory of Hormones and Development, Tianjin Medical University, Tianjin, China.; Tianjin Key Laboratory of Metabolic Diseases, Chu Hsien-I Memorial Hospital & Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin, China.; Department of Pharmacy, General Hospital, Tianjin Medical University, Tianjin, China.
Lv X; Department of Immunology, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Tianjin Medical University, Tianjin, China.; NHC Key Laboratory of Hormones and Development, Tianjin Medical University, Tianjin, China.; Tianjin Key Laboratory of Metabolic Diseases, Chu Hsien-I Memorial Hospital & Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin, China.; Department of Pharmacy, General Hospital, Tianjin Medical University, Tianjin, China.; Clinical Laboratory, Cangzhou People's Hospital, Cangzhou, China.
Zhang S; Department of Immunology, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Tianjin Medical University, Tianjin, China.; NHC Key Laboratory of Hormones and Development, Tianjin Medical University, Tianjin, China.; Tianjin Key Laboratory of Metabolic Diseases, Chu Hsien-I Memorial Hospital & Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin, China.; Department of Pharmacy, General Hospital, Tianjin Medical University, Tianjin, China.
Yang J; Department of Immunology, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Tianjin Medical University, Tianjin, China.; NHC Key Laboratory of Hormones and Development, Tianjin Medical University, Tianjin, China.; Tianjin Key Laboratory of Metabolic Diseases, Chu Hsien-I Memorial Hospital & Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin, China.; Department of Pharmacy, General Hospital, Tianjin Medical University, Tianjin, China.
Chen L; Department of Immunology, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Tianjin Medical University, Tianjin, China.; NHC Key Laboratory of Hormones and Development, Tianjin Medical University, Tianjin, China.; Tianjin Key Laboratory of Metabolic Diseases, Chu Hsien-I Memorial Hospital & Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin, China.; Department of Pharmacy, General Hospital, Tianjin Medical University, Tianjin, China.
Duan H; Department of Immunology, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Tianjin Medical University, Tianjin, China.; NHC Key Laboratory of Hormones and Development, Tianjin Medical University, Tianjin, China.; Tianjin Key Laboratory of Metabolic Diseases, Chu Hsien-I Memorial Hospital & Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin, China.; Department of Pharmacy, General Hospital, Tianjin Medical University, Tianjin, China.
Zhang Y; Institute of Vascular Medicine, Peking University Third Hospital, Beijing, China.
Yao Z; Department of Immunology, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Tianjin Medical University, Tianjin, China.; NHC Key Laboratory of Hormones and Development, Tianjin Medical University, Tianjin, China.; Tianjin Key Laboratory of Metabolic Diseases, Chu Hsien-I Memorial Hospital & Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin, China.; Department of Pharmacy, General Hospital, Tianjin Medical University, Tianjin, China.
Niu W; Department of Immunology, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Tianjin Medical University, Tianjin, China.; NHC Key Laboratory of Hormones and Development, Tianjin Medical University, Tianjin, China.; Tianjin Key Laboratory of Metabolic Diseases, Chu Hsien-I Memorial Hospital & Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin, China.; Department of Pharmacy, General Hospital, Tianjin Medical University, Tianjin, China.
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Źródło :
FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2021 Feb; Vol. 35 (2), pp. e21210. Date of Electronic Publication: 2020 Nov 22.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Muscle Contraction*
Glucose/*metabolism
Muscle Fibers, Skeletal/*metabolism
Neuropeptides/*metabolism
T-Lymphoma Invasion and Metastasis-inducing Protein 1/*metabolism
rac1 GTP-Binding Protein/*metabolism
Animals ; Cell Line ; Glucose Transporter Type 4/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Protein Kinases/metabolism ; T-Lymphoma Invasion and Metastasis-inducing Protein 1/genetics
Czasopismo naukowe
Tytuł :
TIAM1 Upregulation Confers NVP-BEZ235 Resistance to Breast Cancer Cells Through FGFR/STAT3 Pathway.
Autorzy :
Qiao J; Department of Oncology, The Second Affiliated Hospital of Dalian Medical University, No. 467 Zhongshan Road, Shahekou District, Dalian City, 116027, Liaoning Province, China.
Li M; Department of Oncology, The Second Affiliated Hospital of Dalian Medical University, No. 467 Zhongshan Road, Shahekou District, Dalian City, 116027, Liaoning Province, China.
Li N; Department of Oncology, The Second Affiliated Hospital of Dalian Medical University, No. 467 Zhongshan Road, Shahekou District, Dalian City, 116027, Liaoning Province, China.
Xu L; Department of Oncology, The Second Affiliated Hospital of Dalian Medical University, No. 467 Zhongshan Road, Shahekou District, Dalian City, 116027, Liaoning Province, China.
Huang G; Department of Oncology, The Second Affiliated Hospital of Dalian Medical University, No. 467 Zhongshan Road, Shahekou District, Dalian City, 116027, Liaoning Province, China.
Yu J; Department of Oncology, The Second Affiliated Hospital of Dalian Medical University, No. 467 Zhongshan Road, Shahekou District, Dalian City, 116027, Liaoning Province, China. .
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Źródło :
Biochemical genetics [Biochem Genet] 2020 Dec; Vol. 58 (6), pp. 953-965. Date of Electronic Publication: 2020 Jul 15.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Resistance, Neoplasm*
Gene Expression Regulation, Neoplastic*
Up-Regulation*
Breast Neoplasms/*metabolism
Imidazoles/*pharmacology
Neoplasm Proteins/*biosynthesis
Quinolines/*pharmacology
Receptor, Fibroblast Growth Factor, Type 1/*metabolism
Receptor, Fibroblast Growth Factor, Type 3/*metabolism
STAT3 Transcription Factor/*metabolism
T-Lymphoma Invasion and Metastasis-inducing Protein 1/*biosynthesis
Female ; Humans ; MCF-7 Cells ; Neoplasm Proteins/genetics ; Receptor, Fibroblast Growth Factor, Type 1/genetics ; Receptor, Fibroblast Growth Factor, Type 3/genetics ; STAT3 Transcription Factor/genetics ; T-Lymphoma Invasion and Metastasis-inducing Protein 1/genetics
Czasopismo naukowe
Tytuł :
БЕЛОЗЕРСКИЕ МОНАСТЫРИ В КРИЗИСНЫЕ ГОДЫ (1570–1610-е гг.).
Autorzy :
Дмитриева, Зоя Васильевна
Румынская, Марина Николаев&
Сазонова, Татьяна Викторо&
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Alternatywny tytuł :
BELOZERSK MONASTERIES IN CRISIS YEARS (1570s – 1610s).
Źródło :
Science Journal of Volgograd State University. History. Area Studies. International Relations / Vestnik Volgogradskogo Gosudarstvennogo Universiteta. Seriâ 4, Istoriâ, Regionovedenie, Mezdunarodnye Otnošeniâ. 2021, Vol. 26 Issue 5, p72-83. 12p.
Czasopismo naukowe
Tytuł :
Myoblast Migration and Directional Persistence Affected by Syndecan-4-Mediated Tiam-1 Expression and Distribution.
Autorzy :
Becsky D; Department of Biochemistry, Faculty of Medicine, University of Szeged, H-6720 Szeged, Hungary.
Gyulai-Nagy S; Department of Biochemistry, Faculty of Medicine, University of Szeged, H-6720 Szeged, Hungary.
Balind A; Institute of Biochemistry, Biological Research Centre, Hungarian Academy of Sciences, H-6726 Szeged, Hungary.
Horvath P; Institute of Biochemistry, Biological Research Centre, Hungarian Academy of Sciences, H-6726 Szeged, Hungary.
Dux L; Department of Biochemistry, Faculty of Medicine, University of Szeged, H-6720 Szeged, Hungary.
Keller-Pinter A; Department of Biochemistry, Faculty of Medicine, University of Szeged, H-6720 Szeged, Hungary.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Jan 27; Vol. 21 (3). Date of Electronic Publication: 2020 Jan 27.
Typ publikacji :
Journal Article
MeSH Terms :
Cell Movement*
Gene Expression Regulation*
Myoblasts/*metabolism
Syndecan-4/*metabolism
T-Lymphoma Invasion and Metastasis-inducing Protein 1/*biosynthesis
Animals ; Cell Line ; Gene Knockdown Techniques ; Mice ; Myoblasts/cytology ; Syndecan-4/genetics ; T-Lymphoma Invasion and Metastasis-inducing Protein 1/genetics
Czasopismo naukowe
Tytuł :
The role of CaMKII-Tiam1 complex on learning and memory.
Autorzy :
Kojima H; Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo Bunkyo-ku, Tokyo 113-0033, Japan; Department of Pharmacology, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan; RIKEN Brain Science Institute, Wako, Saitama 351-0198, Japan.
Rosendale M; Department of Pharmacology, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan; RIKEN Brain Science Institute, Wako, Saitama 351-0198, Japan.
Sugiyama Y; Department of Pharmacology, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan.
Hayashi M; Institute of Laboratory Animals, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan.
Horiguchi Y; Institute of Laboratory Animals, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan.
Yoshihara T; Institute of Laboratory Animals, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan.
Ikegaya Y; Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo Bunkyo-ku, Tokyo 113-0033, Japan.
Saneyoshi T; Department of Pharmacology, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan; RIKEN Brain Science Institute, Wako, Saitama 351-0198, Japan. Electronic address: .
Hayashi Y; Department of Pharmacology, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan; RIKEN Brain Science Institute, Wako, Saitama 351-0198, Japan. Electronic address: .
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Źródło :
Neurobiology of learning and memory [Neurobiol Learn Mem] 2019 Dec; Vol. 166, pp. 107070. Date of Electronic Publication: 2019 Aug 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Calcium-Calmodulin-Dependent Protein Kinase Type 2/*metabolism
Dendritic Spines/*metabolism
Learning/*physiology
Long-Term Potentiation/*physiology
Memory/*physiology
T-Lymphoma Invasion and Metastasis-inducing Protein 1/*metabolism
Animals ; Hippocampus/metabolism ; Mice, Transgenic ; Neurons/metabolism ; Phosphorylation ; Recognition, Psychology/physiology ; T-Lymphoma Invasion and Metastasis-inducing Protein 1/genetics
Czasopismo naukowe
Tytuł :
Tumor-associated mesenchymal stem cells promote hepatocellular carcinoma metastasis via a DNM3OS/KDM6B/TIAM1 axis.
Autorzy :
Wang W; Department of Medical Oncology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
Wang Q; Department of Radiotherapy, Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Department of Oncology, The Fifth Hospital of Wuhan, Wuhan, China; WuHan University, Wuhan, China.
Huang DB; Department of Medical Oncology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
Sun QK; Department of Hepatobiliary Surgery, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China.
Wu SS; Department of Medical Oncology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
Zhao YJ; Department of Abdominal Surgery, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
Jia W; Department of Medical Oncology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
Hu DS; Department of Radiotherapy, Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address: .
He YF; Department of Medical Oncology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China. Electronic address: .
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Źródło :
Cancer letters [Cancer Lett] 2021 Apr 10; Vol. 503, pp. 19-31. Date of Electronic Publication: 2021 Jan 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Carcinoma, Hepatocellular/*pathology
Jumonji Domain-Containing Histone Demethylases/*genetics
Liver Neoplasms/*pathology
Neoplastic Stem Cells/*chemistry
RNA, Long Noncoding/*genetics
T-Lymphoma Invasion and Metastasis-inducing Protein 1/*genetics
Animals ; Carcinoma, Hepatocellular/genetics ; Cell Culture Techniques ; Cell Line, Tumor ; Cell Movement ; Cell Proliferation ; Culture Media, Conditioned/chemistry ; Epithelial-Mesenchymal Transition ; Gene Expression Regulation, Neoplastic ; HEK293 Cells ; Humans ; Liver Neoplasms/genetics ; Male ; Mice ; Neoplasm Metastasis ; Neoplasm Transplantation
Czasopismo naukowe
Tytuł :
Cryo-EM structure of CtBP2 confirms tetrameric architecture.
Autorzy :
Jecrois AM; Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA.
Dcona MM; Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA 23298, USA.
Deng X; Department of Biostatistics, Virginia Commonwealth University, Richmond, VA 23298, USA.
Bandyopadhyay D; Department of Biostatistics, Virginia Commonwealth University, Richmond, VA 23298, USA; Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298, USA.
Grossman SR; Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA 23298, USA; Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298, USA.
Schiffer CA; Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA.
Royer WE Jr; Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA. Electronic address: .
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Źródło :
Structure (London, England : 1993) [Structure] 2021 Apr 01; Vol. 29 (4), pp. 310-319.e5. Date of Electronic Publication: 2020 Dec 01.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Protein Multimerization*
Alcohol Oxidoreductases/*chemistry
Co-Repressor Proteins/*chemistry
DNA-Binding Proteins/*chemistry
Alcohol Oxidoreductases/genetics ; Alcohol Oxidoreductases/metabolism ; Cadherins/metabolism ; Catalytic Domain ; Cell Movement ; Co-Repressor Proteins/genetics ; Co-Repressor Proteins/metabolism ; Cryoelectron Microscopy ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; Gene Expression Regulation, Neoplastic ; HCT116 Cells ; Humans ; Mutation ; NADP/metabolism ; Protein Binding ; T-Lymphoma Invasion and Metastasis-inducing Protein 1/metabolism
Czasopismo naukowe
Tytuł :
Effects of 7,8-Dihydroxyflavone on Lipid Isoprenoid and Rho Protein Levels in Brains of Aged C57BL/6 Mice.
Autorzy :
Ötzkan S; Department of Pharmacology, Biocenter Niederursel, University of Frankfurt, Goethe-University, Max-von-Laue-St. 9, 60438, Frankfurt, Germany.
Muller WE; Department of Pharmacology, Biocenter Niederursel, University of Frankfurt, Goethe-University, Max-von-Laue-St. 9, 60438, Frankfurt, Germany.
Gibson Wood W; Department of Pharmacology, Geriatric Research, Education and Clinical Center, University of Minnesota School of Medicine, VAMC, Minneapolis, MN, 55417, USA.
Eckert GP; Department of Pharmacology, Biocenter Niederursel, University of Frankfurt, Goethe-University, Max-von-Laue-St. 9, 60438, Frankfurt, Germany. .; Institute of Nutritional Sciences, Laboratory for Nutrition in Prevention and Therapy, Justus-Liebig-University of Giessen, Biomedical Research Center Seltersberg (BFS), Schubertstr. 81, 35392, Giessen, Germany. .
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Źródło :
Neuromolecular medicine [Neuromolecular Med] 2021 Mar; Vol. 23 (1), pp. 130-139. Date of Electronic Publication: 2020 Dec 30.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Brain Chemistry/*drug effects
Flavones/*pharmacology
Polyisoprenyl Phosphates/*metabolism
Sesquiterpenes/*metabolism
Terpenes/*metabolism
Aging/metabolism ; Animals ; Brain/growth & development ; Brain/metabolism ; Cholesterol/metabolism ; Male ; Membrane Glycoproteins/agonists ; Membrane Proteins/metabolism ; Mice ; Mice, Inbred C57BL ; Nerve Tissue Proteins/metabolism ; Neuropeptides/metabolism ; Protein Prenylation ; Protein Processing, Post-Translational ; Protein-Tyrosine Kinases ; T-Lymphoma Invasion and Metastasis-inducing Protein 1/metabolism ; rab3A GTP-Binding Protein/metabolism ; rac1 GTP-Binding Protein/metabolism
Czasopismo naukowe

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