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Wyszukujesz frazę ""leucine-rich repeat serine-threonine protein kinase-2"" wg kryterium: Temat


Tytuł:
Rab29-dependent asymmetrical activation of leucine-rich repeat kinase 2.
Autorzy:
Zhu H; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Tonelli F; MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA.
Turk M; Cryo-EM and Tomography Center, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Prescott A; MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.
Alessi DR; MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA.
Sun J; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
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Źródło:
Science (New York, N.Y.) [Science] 2023 Dec 22; Vol. 382 (6677), pp. 1404-1411. Date of Electronic Publication: 2023 Dec 21.
Typ publikacji:
Journal Article
MeSH Terms:
Leucine-Rich Repeat Serine-Threonine Protein Kinase-2*/antagonists & inhibitors
Leucine-Rich Repeat Serine-Threonine Protein Kinase-2*/chemistry
Leucine-Rich Repeat Serine-Threonine Protein Kinase-2*/genetics
Parkinson Disease*/drug therapy
Parkinson Disease*/genetics
rab GTP-Binding Proteins*/chemistry
Humans ; Antiparkinson Agents/chemistry ; Antiparkinson Agents/pharmacology ; Catalytic Domain ; Cryoelectron Microscopy ; Drug Design ; Gain of Function Mutation ; Protein Subunits/chemistry ; Protein Multimerization ; Protein Kinase Inhibitors/chemistry ; Protein Kinase Inhibitors/pharmacology
SCR Disease Name:
Parkinson Disease 16
Czasopismo naukowe
Tytuł:
Tyrosine Metabolism Pathway Is Downregulated in Dopaminergic Neurons with LRRK2 Overexpression in Drosophila .
Autorzy:
Cheng J; Graduate Institute of Integrated Medicine, College of Chinese Medicine, China Medical University, Taichung 40402, Taiwan.; Department of Medical Research, China Medical University Hospital, Taichung 40447, Taiwan.
Wu BT; Department of Senior Citizen Service Management, National Taichung University of Science and Technology, Taichung 40343, Taiwan.
Liu HP; Graduate Institute of Acupuncture Science, College of Chinese Medicine, China Medical University, Taichung 40402, Taiwan.
Lin WY; Graduate Institute of Integrated Medicine, College of Chinese Medicine, China Medical University, Taichung 40402, Taiwan.; Department of Medical Research, China Medical University Hospital, Taichung 40447, Taiwan.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Oct 25; Vol. 24 (21). Date of Electronic Publication: 2023 Oct 25.
Typ publikacji:
Journal Article
MeSH Terms:
Dopaminergic Neurons*/metabolism
Leucine-Rich Repeat Serine-Threonine Protein Kinase-2*/genetics
Leucine-Rich Repeat Serine-Threonine Protein Kinase-2*/metabolism
Parkinson Disease*/genetics
Parkinson Disease*/metabolism
Animals ; Humans ; Drosophila/genetics ; Mutation ; Nerve Degeneration/metabolism ; Tyrosine/metabolism
Czasopismo naukowe
Tytuł:
The Avidity of Autoreactive Alpha-Synuclein Antibodies in Leucine-Rich Repeat Kinase 2 Mutation Carriers Is Not Altered Compared to Healthy Controls or Patients with Parkinson's Disease.
Autorzy:
Albus A; Therapy Research in Neurogeriatrics, Center for Translational Neuro- and Behavioral Sciences, University of Duisburg-Essen, University Hospital Essen, 45147 Essen, Germany.; Department for Neurology, Philipps-University Marburg, 35037 Marburg, Germany.
Kronimus Y; Therapy Research in Neurogeriatrics, Center for Translational Neuro- and Behavioral Sciences, University of Duisburg-Essen, University Hospital Essen, 45147 Essen, Germany.; Department for Neurology, Philipps-University Marburg, 35037 Marburg, Germany.
Burg-Roderfeld M; Department of Chemistry and Biology, Fresenius University of Applied Sciences, 65510 Idstein, Germany.
van der Wurp H; Therapy Research in Neurogeriatrics, Center for Translational Neuro- and Behavioral Sciences, University of Duisburg-Essen, University Hospital Essen, 45147 Essen, Germany.; Faculty of Statistics, TU Dortmund University, 44227 Dortmund, Germany.
Willbold D; Institute of Physical Biology, Heinrich Heine University Düsseldorf, 40225 Düsseldorf, Germany.; Institute of Biological Information Processing (IBI-7: Structural Biochemistry), Forschungszentrum Jülich, 52428 Jülich, Germany.
Ziehm T; Institute of Physical Biology, Heinrich Heine University Düsseldorf, 40225 Düsseldorf, Germany.
Dodel R; Therapy Research in Neurogeriatrics, Center for Translational Neuro- and Behavioral Sciences, University of Duisburg-Essen, University Hospital Essen, 45147 Essen, Germany.; Department for Neurology, Philipps-University Marburg, 35037 Marburg, Germany.
Ross JA; Therapy Research in Neurogeriatrics, Center for Translational Neuro- and Behavioral Sciences, University of Duisburg-Essen, University Hospital Essen, 45147 Essen, Germany.
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Źródło:
Biomolecules [Biomolecules] 2023 Aug 25; Vol. 13 (9). Date of Electronic Publication: 2023 Aug 25.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
alpha-Synuclein*/immunology
Parkinson Disease*/genetics
Leucine-Rich Repeat Serine-Threonine Protein Kinase-2*/genetics
Humans ; Autoantibodies ; Leucine ; Mutation
Czasopismo naukowe
Tytuł:
LRRK2 kinase inhibition reverses G2019S mutation-dependent effects on tau pathology progression.
Autorzy:
Lubben N; Department of Neurodegenerative Science, Van Andel Institute, 333 Bostwick Ave NE, Grand Rapids, MI, 49503, USA.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815, USA.
Brynildsen JK; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815, USA.; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Webb CM; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, Institute On Aging and Center for Neurodegenerative Disease Research, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Li HL; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, Institute On Aging and Center for Neurodegenerative Disease Research, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Leyns CEG; Neuroscience Discovery, Merck & Co., Inc., Boston, MA, 02115, USA.
Changolkar L; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, Institute On Aging and Center for Neurodegenerative Disease Research, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Zhang B; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, Institute On Aging and Center for Neurodegenerative Disease Research, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Meymand ES; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, Institute On Aging and Center for Neurodegenerative Disease Research, University of Pennsylvania, Philadelphia, PA, 19104, USA.
O'Reilly M; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Madaj Z; Bioinformatics and Biostatistics Core, Van Andel Institute, 333 Bostwick Ave., NE, Grand Rapids, MI, 49503, USA.
DeWeerd D; Department of Neurodegenerative Science, Van Andel Institute, 333 Bostwick Ave NE, Grand Rapids, MI, 49503, USA.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815, USA.
Fell MJ; Neuroscience Discovery, Merck & Co., Inc., Boston, MA, 02115, USA.
Lee VMY; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, Institute On Aging and Center for Neurodegenerative Disease Research, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Bassett DS; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815, USA.; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Department of Electrical and Systems Engineering, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Department of Neurology, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Santa Fe Institute, Santa Fe, NM, 87501, USA.
Henderson MX; Department of Neurodegenerative Science, Van Andel Institute, 333 Bostwick Ave NE, Grand Rapids, MI, 49503, USA. .; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815, USA. .
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Źródło:
Translational neurodegeneration [Transl Neurodegener] 2024 Mar 04; Vol. 13 (1), pp. 13. Date of Electronic Publication: 2024 Mar 04.
Typ publikacji:
Journal Article
MeSH Terms:
Brain*
Dopaminergic Neurons*
Animals ; Humans ; Mice ; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2/genetics ; Lewy Bodies ; Mice, Transgenic ; Mutation/genetics
Czasopismo naukowe
Tytuł:
Comprehensive analysis of clinical and biological features in Parkinson's disease associated with the LRRK2 G2019S mutation: Data from the PPMI study.
Autorzy:
Sun X; Department of Neurology, Affiliated Hospital of Qingdao University, Qingdao, China.
Dou K; Department of Neurology, Affiliated Hospital of Qingdao University, Qingdao, China.
Xue L; Recording Room, The Affiliated Hospital of Qingdao University, Qingdao, China.
Xie Y; Clinical Laboratory, Central Laboratory, Qingdao Hiser Hospital Affiliated of Qingdao University (Qingdao Traditional Chinese Medicine Hospital), Qingdao, China.
Yang Y; Department of Neurology, Affiliated Hospital of Qingdao University, Qingdao, China.
Xie A; Department of Neurology, Affiliated Hospital of Qingdao University, Qingdao, China.; Cerebral Vascular Disease Institute, Affiliated Hospital of Qingdao University, Qingdao, China.
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Źródło:
Clinical and translational science [Clin Transl Sci] 2024 Jan; Vol. 17 (1), pp. e13720.
Typ publikacji:
Journal Article
MeSH Terms:
Parkinson Disease*/diagnosis
Parkinson Disease*/genetics
Humans ; Activities of Daily Living ; Mutation ; Mutation, Missense ; Databases, Factual ; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2/genetics
Czasopismo naukowe
Tytuł:
The Relationship between Iron and LRRK2 in a 6-OHDA-Induced Parkinson's Disease Model.
Autorzy:
Jia R; Laboratory of Hypoxic Biomedicine, Institute of Special Environmental Medicine, Co-Innovation Center of Neuroregeneration, Nantong University, 9 Seyuan Road, Nantong 226019, China.
Liu Y; Laboratory of Hypoxic Biomedicine, Institute of Special Environmental Medicine, Co-Innovation Center of Neuroregeneration, Nantong University, 9 Seyuan Road, Nantong 226019, China.
Shuai K; Laboratory of Hypoxic Biomedicine, Institute of Special Environmental Medicine, Co-Innovation Center of Neuroregeneration, Nantong University, 9 Seyuan Road, Nantong 226019, China.
Zhou C; Laboratory of Hypoxic Biomedicine, Institute of Special Environmental Medicine, Co-Innovation Center of Neuroregeneration, Nantong University, 9 Seyuan Road, Nantong 226019, China.
Chen L; Laboratory of Hypoxic Biomedicine, Institute of Special Environmental Medicine, Co-Innovation Center of Neuroregeneration, Nantong University, 9 Seyuan Road, Nantong 226019, China.
Zhu L; Laboratory of Hypoxic Biomedicine, Institute of Special Environmental Medicine, Co-Innovation Center of Neuroregeneration, Nantong University, 9 Seyuan Road, Nantong 226019, China.
Wu XM; Laboratory of Hypoxic Biomedicine, Institute of Special Environmental Medicine, Co-Innovation Center of Neuroregeneration, Nantong University, 9 Seyuan Road, Nantong 226019, China.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Feb 13; Vol. 24 (4). Date of Electronic Publication: 2023 Feb 13.
Typ publikacji:
Journal Article
MeSH Terms:
Iron*/metabolism
Leucine-Rich Repeat Serine-Threonine Protein Kinase-2*/metabolism
Parkinson Disease*/metabolism
Parkinson Disease*/pathology
Animals ; Rats ; Dopaminergic Neurons/metabolism ; Dopaminergic Neurons/pathology ; Mutation ; Oxidopamine/pharmacology ; Oxidopamine/toxicity ; Substantia Nigra/metabolism ; Substantia Nigra/pathology ; Disease Models, Animal
Czasopismo naukowe
Tytuł:
An Update on the Interplay between LRRK2, Rab GTPases and Parkinson's Disease.
Autorzy:
Komori T; Department of Neuropathology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan.
Kuwahara T; Department of Neuropathology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan.
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Źródło:
Biomolecules [Biomolecules] 2023 Nov 13; Vol. 13 (11). Date of Electronic Publication: 2023 Nov 13.
Typ publikacji:
Journal Article; Review; Research Support, Non-U.S. Gov't
MeSH Terms:
Parkinson Disease*/metabolism
Humans ; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2/genetics ; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2/metabolism ; rab GTP-Binding Proteins/genetics ; rab GTP-Binding Proteins/metabolism ; Endosomes/metabolism ; Endocytosis ; Mutation
Czasopismo naukowe
Tytuł:
LRRK2 Attenuates Antioxidant Response in Familial Parkinson's Disease Derived Neural Stem Cells.
Autorzy:
Kim J; Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX 78227, USA.; Department of Cell Systems & Anatomy, San Antonio, TX 78229, USA.
Daadi EW; Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX 78227, USA.
Daadi ES; Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX 78227, USA.
Oh T; Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX 78227, USA.
Deleidi M; Institut Imagine, INSERM UMR1163, Paris Cité University, 75015 Paris, France.
Daadi MM; Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX 78227, USA.; Department of Cell Systems & Anatomy, San Antonio, TX 78229, USA.; Department of Radiology, Long School of Medicine, University of Texas Health at San Antonio, 7703 Floyd Curl Dr., San Antonio, TX 78229, USA.
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Źródło:
Cells [Cells] 2023 Oct 31; Vol. 12 (21). Date of Electronic Publication: 2023 Oct 31.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Parkinson Disease*/metabolism
Neurodegenerative Diseases*/metabolism
Neural Stem Cells*/metabolism
Humans ; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2/genetics ; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2/metabolism ; Antioxidants/pharmacology ; Antioxidants/metabolism ; Kelch-Like ECH-Associated Protein 1/metabolism ; Reactive Oxygen Species/metabolism ; Hydrogen Peroxide/metabolism ; NF-E2-Related Factor 2/genetics ; NF-E2-Related Factor 2/metabolism
Czasopismo naukowe
Tytuł:
LRRK2 is involved in the chemotaxis of neutrophils and differentiated HL-60 cells, and the inhibition of LRRK2 kinase activity increases fMLP-induced chemotactic activity.
Autorzy:
Mazaki Y; Department of Cellular Pharmacology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan. .
Handa H; Department of Molecular Biology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
Fumoto Y; Department of Molecular Biology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
Horinouchi T; Department of Cellular Pharmacology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
Onodera Y; Global Center for Biomedical Science and Engineering (GCB), Faculty of Medicine, Hokkaido University, Sapporo, Japan.
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Źródło:
Cell communication and signaling : CCS [Cell Commun Signal] 2023 Oct 30; Vol. 21 (1), pp. 300. Date of Electronic Publication: 2023 Oct 30.
Typ publikacji:
Video-Audio Media; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Chemotaxis*
Neutrophils*/metabolism
Humans ; HL-60 Cells ; Oxidative Phosphorylation ; RNA, Small Interfering/metabolism ; Guanosine Triphosphate/metabolism ; Guanosine Triphosphate/pharmacology ; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2/metabolism ; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2/pharmacology
Czasopismo naukowe
Tytuł:
Advances in Gene Therapy Techniques to Treat LRRK2 Gene Mutation.
Autorzy:
Chung SK; Division of KM Science Research, Korea Institute of Oriental Medicine, 1672 Yuseong-daero, Yuseong-gu, Daejeon 34054, Republic of Korea.
Lee SY; Division of KM Science Research, Korea Institute of Oriental Medicine, 1672 Yuseong-daero, Yuseong-gu, Daejeon 34054, Republic of Korea.
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Źródło:
Biomolecules [Biomolecules] 2022 Dec 05; Vol. 12 (12). Date of Electronic Publication: 2022 Dec 05.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
Genetic Therapy*
Leucine-Rich Repeat Serine-Threonine Protein Kinase-2*/genetics
Parkinson Disease*/genetics
Parkinson Disease*/therapy
Humans ; Gene Editing ; Mutation
Czasopismo naukowe
Tytuł:
Differential LRRK2 Signalling and Gene Expression in WT-LRRK2 and G2019S-LRRK2 Mouse Microglia Treated with Zymosan and MLi2.
Autorzy:
Nazish I; Reta Lila Weston Institute of Neurological Studies and Department of Movement neuroscience, UCL Queen Square Institute of Neurology, London WC1N 1PJ, UK.
Mamais A; Center for Translational Research in Neurodegenerative Disease, Department of Neurology, University of Florida, Gainesville, FL 32610, USA.
Mallach A; Department of Neuroinflammation, UCL Queen Square Institute of Neurology, University College London, London WC1N 1PJ, UK.
Bettencourt C; Department of Neurodegenerative Diseases, UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK.
Kaganovich A; Cell Biology and Gene Expression Section, National Institute on Aging, Bethesda, MD 20892, USA.
Warner T; Reta Lila Weston Institute of Neurological Studies and Department of Movement neuroscience, UCL Queen Square Institute of Neurology, London WC1N 1PJ, UK.
Hardy J; Department of Neurodegenerative Diseases, UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK.
Lewis PA; Department of Neurodegenerative Diseases, UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK.; Royal Veterinary College, University of London, London NW1 0TU, UK.
Pocock J; Department of Neuroinflammation, UCL Queen Square Institute of Neurology, University College London, London WC1N 1PJ, UK.
Cookson MR; Cell Biology and Gene Expression Section, National Institute on Aging, Bethesda, MD 20892, USA.
Bandopadhyay R; Reta Lila Weston Institute of Neurological Studies and Department of Movement neuroscience, UCL Queen Square Institute of Neurology, London WC1N 1PJ, UK.
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Źródło:
Cells [Cells] 2023 Dec 26; Vol. 13 (1). Date of Electronic Publication: 2023 Dec 26.
Typ publikacji:
Journal Article
MeSH Terms:
Microglia*
Parkinson Disease*/genetics
Humans ; Animals ; Mice ; Zymosan/pharmacology ; Genome-Wide Association Study ; Toll-Like Receptor 2/genetics ; Gene Expression ; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2/genetics
Czasopismo naukowe
Tytuł:
Human iPSC-derived microglia carrying the LRRK2-G2019S mutation show a Parkinson's disease related transcriptional profile and function.
Autorzy:
Ohtonen S; A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland. .
Giudice L; A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.
Jäntti H; A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.; F.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Fazaludeen MF; A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.
Shakirzyanova A; A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.
Gómez-Budia M; A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.
Välimäki NN; A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.
Niskanen J; A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.
Korvenlaita N; A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.
Fagerlund I; A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.
Koistinaho J; A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.; Neuroscience Center, University of Helsinki, Helsinki, Finland.
Amiry-Moghaddam M; Division of Anatomy, Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
Savchenko E; Stem Cell Laboratory for CNS Disease Modeling, Department of Experimental Medical Science, Lund University, Lund, Sweden.
Roybon L; Stem Cell Laboratory for CNS Disease Modeling, Department of Experimental Medical Science, Lund University, Lund, Sweden.; Department of Neurodegenerative Science, The MiND Program, Van Andel Institute, Grand Rapids, MI, USA.
Lehtonen Š; A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.; Neuroscience Center, University of Helsinki, Helsinki, Finland.
Korhonen P; A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.
Malm T; A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.
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Źródło:
Scientific reports [Sci Rep] 2023 Dec 13; Vol. 13 (1), pp. 22118. Date of Electronic Publication: 2023 Dec 13.
Typ publikacji:
Journal Article
MeSH Terms:
Induced Pluripotent Stem Cells*
Parkinson Disease*/genetics
Humans ; Microglia ; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2/genetics ; Mutation ; Gene Expression
Czasopismo naukowe
Tytuł:
Differences in EEG Event-Related Potentials during Dual Task in Parkinson's Disease Carriers and Non-Carriers of the G2019S-LRRK2 Mutation.
Autorzy:
Shkury E; Laboratory of Early Markers of Neurodegeneration, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv 6423906, Israel.; School of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel.
Danziger-Schragenheim S; Laboratory of Early Markers of Neurodegeneration, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv 6423906, Israel.; Sagol School of Neuroscience, Tel Aviv University, Tel Aviv 6997801, Israel.
Katzir Z; Laboratory of Early Markers of Neurodegeneration, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv 6423906, Israel.; School of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel.
Ezra Y; Laboratory of Early Markers of Neurodegeneration, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv 6423906, Israel.; Sagol School of Neuroscience, Tel Aviv University, Tel Aviv 6997801, Israel.
Giladi N; Laboratory of Early Markers of Neurodegeneration, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv 6423906, Israel.; School of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel.; Sagol School of Neuroscience, Tel Aviv University, Tel Aviv 6997801, Israel.
Mirelman A; Laboratory of Early Markers of Neurodegeneration, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv 6423906, Israel.; School of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel.; Sagol School of Neuroscience, Tel Aviv University, Tel Aviv 6997801, Israel.
Maidan I; Laboratory of Early Markers of Neurodegeneration, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv 6423906, Israel.; School of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel.; Sagol School of Neuroscience, Tel Aviv University, Tel Aviv 6997801, Israel.
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Źródło:
Sensors (Basel, Switzerland) [Sensors (Basel)] 2023 Oct 06; Vol. 23 (19). Date of Electronic Publication: 2023 Oct 06.
Typ publikacji:
Journal Article
MeSH Terms:
Parkinson Disease*/genetics
Humans ; Evoked Potentials ; Mutation ; Phenotype ; Electroencephalography ; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2/genetics
Czasopismo naukowe
Tytuł:
A leucine-rich repeat kinase 2 (LRRK2) pathway biomarker characterization study in patients with Parkinson's disease with and without LRRK2 mutations and healthy controls.
Autorzy:
Vissers MFJM; Centre for Human Drug Research, Leiden, The Netherlands.; Leiden University Medical Center, Leiden, The Netherlands.
Troyer MD; Denali Therapeutics Inc., South San Francisco, California, USA.
Thijssen E; Centre for Human Drug Research, Leiden, The Netherlands.; Leiden University Medical Center, Leiden, The Netherlands.
Pereira DR; Denali Therapeutics Inc., South San Francisco, California, USA.
Heuberger JAAC; Centre for Human Drug Research, Leiden, The Netherlands.
Groeneveld GJ; Centre for Human Drug Research, Leiden, The Netherlands.; Leiden University Medical Center, Leiden, The Netherlands.
Huntwork-Rodriguez S; Denali Therapeutics Inc., South San Francisco, California, USA.
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Źródło:
Clinical and translational science [Clin Transl Sci] 2023 Aug; Vol. 16 (8), pp. 1408-1420. Date of Electronic Publication: 2023 May 15.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Parkinson Disease*/diagnosis
Parkinson Disease*/genetics
Humans ; Leucine/metabolism ; Leukocytes, Mononuclear/metabolism ; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2/genetics ; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2/metabolism ; Mutation ; Biomarkers/metabolism
Czasopismo naukowe
Tytuł:
LRRK2 dynamics analysis identifies allosteric control of the crosstalk between its catalytic domains.
Autorzy:
Weng JH; Department of Pharmacology, University of California, San Diego, California, United States of America.
Aoto PC; Department of Pharmacology, University of California, San Diego, California, United States of America.
Lorenz R; Department of Biochemistry, University of Kassel, Kassel, Germany.
Wu J; Department of Pharmacology, University of California, San Diego, California, United States of America.
Schmidt SH; Department of Biochemistry, University of Kassel, Kassel, Germany.
Manschwetus JT; Department of Biochemistry, University of Kassel, Kassel, Germany.
Kaila-Sharma P; Department of Pharmacology, University of California, San Diego, California, United States of America.
Silletti S; Department of Chemistry and Biochemistry, University of California, San Diego, California, United States of America.
Mathea S; Institute for Pharmaceutical Chemistry, Goethe University Frankfurt, Frankfurt am Main, Germany.
Chatterjee D; Institute for Pharmaceutical Chemistry, Goethe University Frankfurt, Frankfurt am Main, Germany.
Knapp S; Institute for Pharmaceutical Chemistry, Goethe University Frankfurt, Frankfurt am Main, Germany.
Herberg FW; Department of Biochemistry, University of Kassel, Kassel, Germany.
Taylor SS; Department of Pharmacology, University of California, San Diego, California, United States of America.
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Źródło:
PLoS biology [PLoS Biol] 2022 Feb 22; Vol. 20 (2), pp. e3001427. Date of Electronic Publication: 2022 Feb 22 (Print Publication: 2022).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Catalytic Domain*
Molecular Dynamics Simulation*
Protein Conformation*
Leucine-Rich Repeat Serine-Threonine Protein Kinase-2/*chemistry
Allosteric Regulation ; Allosteric Site ; Deuterium Exchange Measurement/methods ; Humans ; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2/genetics ; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2/metabolism ; Mass Spectrometry/methods ; Mutation ; Protein Binding
Czasopismo naukowe
Tytuł:
LRRK2 at Striatal Synapses: Cell-Type Specificity and Mechanistic Insights.
Autorzy:
Skelton PD; Department of Pharmacology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Tokars V; Department of Pharmacology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Parisiadou L; Department of Pharmacology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
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Źródło:
Cells [Cells] 2022 Jan 05; Vol. 11 (1). Date of Electronic Publication: 2022 Jan 05.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
Corpus Striatum/*enzymology
Leucine-Rich Repeat Serine-Threonine Protein Kinase-2/*metabolism
Synapses/*enzymology
Amino Acid Sequence ; Animals ; Disease Models, Animal ; Humans ; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2/chemistry ; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2/genetics ; Models, Biological ; Mutation/genetics
Czasopismo naukowe
Tytuł:
LRRK2 Kinase Inhibition Attenuates Neuroinflammation and Cytotoxicity in Animal Models of Alzheimer's and Parkinson's Disease-Related Neuroinflammation.
Autorzy:
Mutti V; IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, 25125 Brescia, Italy.
Carini G; IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, 25125 Brescia, Italy.; Biology and Genetics Unit, Department of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, Italy.
Filippini A; IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, 25125 Brescia, Italy.; Biology and Genetics Unit, Department of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, Italy.
Castrezzati S; Human Anatomy Unit, Department of Biomedical Sciences and Biotechnologies, University of Brescia, 25123 Brescia, Italy.
Giugno L; Human Anatomy Unit, Department of Biomedical Sciences and Biotechnologies, University of Brescia, 25123 Brescia, Italy.
Gennarelli M; IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, 25125 Brescia, Italy.; Biology and Genetics Unit, Department of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, Italy.
Russo I; IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, 25125 Brescia, Italy.; Biology and Genetics Unit, Department of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, Italy.
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Źródło:
Cells [Cells] 2023 Jul 06; Vol. 12 (13). Date of Electronic Publication: 2023 Jul 06.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Parkinson Disease*/pathology
Alzheimer Disease*/drug therapy
Mice ; Animals ; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2/genetics ; Neuroinflammatory Diseases ; Models, Animal
Czasopismo naukowe
Tytuł:
Astrocytes Differentiated from LRRK2-I1371V Parkinson's-Disease-Induced Pluripotent Stem Cells Exhibit Similar Yield but Cell-Intrinsic Dysfunction in Glutamate Uptake and Metabolism, ATP Generation, and Nrf2-Mediated Glutathione Machinery.
Autorzy:
Banerjee R; Department of Biophysics, National Institute of Mental Health and Neurosciences, Institute of National Importance, Bengaluru 560029, Karnataka, India.
Raj A; Department of Biophysics, National Institute of Mental Health and Neurosciences, Institute of National Importance, Bengaluru 560029, Karnataka, India.
Potdar C; Department of Biophysics, National Institute of Mental Health and Neurosciences, Institute of National Importance, Bengaluru 560029, Karnataka, India.
Kumar Pal P; Department of Neurology, National Institute of Mental Health and Neurosciences, Institute of National Importance, Bengaluru 560029, Karnataka, India.
Yadav R; Department of Neurology, National Institute of Mental Health and Neurosciences, Institute of National Importance, Bengaluru 560029, Karnataka, India.
Kamble N; Department of Neurology, National Institute of Mental Health and Neurosciences, Institute of National Importance, Bengaluru 560029, Karnataka, India.
Holla V; Department of Neurology, National Institute of Mental Health and Neurosciences, Institute of National Importance, Bengaluru 560029, Karnataka, India.
Datta I; Department of Biophysics, National Institute of Mental Health and Neurosciences, Institute of National Importance, Bengaluru 560029, Karnataka, India.
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Źródło:
Cells [Cells] 2023 Jun 08; Vol. 12 (12). Date of Electronic Publication: 2023 Jun 08.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Induced Pluripotent Stem Cells*/metabolism
Parkinson Disease*/metabolism
Humans ; Glutamic Acid/metabolism ; Glutamine/metabolism ; Astrocytes/metabolism ; NF-E2-Related Factor 2/metabolism ; Glutathione/metabolism ; Adenosine Triphosphate/metabolism ; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2/genetics ; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2/metabolism
Czasopismo naukowe
Tytuł:
Overview of the Impact of Pathogenic LRRK2 Mutations in Parkinson's Disease.
Autorzy:
Ito G; Department of Biomolecular Chemistry, Faculty of Pharma-Sciences, Teikyo University, Tokyo 173-8605, Japan.
Utsunomiya-Tate N; Department of Biomolecular Chemistry, Faculty of Pharma-Sciences, Teikyo University, Tokyo 173-8605, Japan.
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Źródło:
Biomolecules [Biomolecules] 2023 May 16; Vol. 13 (5). Date of Electronic Publication: 2023 May 16.
Typ publikacji:
Journal Article; Review; Research Support, Non-U.S. Gov't
MeSH Terms:
Parkinson Disease*/metabolism
Humans ; Protein Serine-Threonine Kinases/metabolism ; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2/genetics ; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2/metabolism ; Mutation ; Lewy Bodies/metabolism
Czasopismo naukowe
Tytuł:
Mutations in LRRK2 linked to Parkinson disease sequester Rab8a to damaged lysosomes and regulate transferrin-mediated iron uptake in microglia.
Autorzy:
Mamais A; Cell Biology and Gene Expression Section, National Institute on Aging, National Institutes of Health, Maryland, United States of America.; Department of Neurology, University of Florida, Gainesville, Florida, United States of America.
Kluss JH; Cell Biology and Gene Expression Section, National Institute on Aging, National Institutes of Health, Maryland, United States of America.
Bonet-Ponce L; Cell Biology and Gene Expression Section, National Institute on Aging, National Institutes of Health, Maryland, United States of America.
Landeck N; Cell Biology and Gene Expression Section, National Institute on Aging, National Institutes of Health, Maryland, United States of America.
Langston RG; Cell Biology and Gene Expression Section, National Institute on Aging, National Institutes of Health, Maryland, United States of America.
Smith N; Department of Biochemistry and the Redox Biology Center, University of Nebraska, Lincoln, Nebraska, United States of America.
Beilina A; Cell Biology and Gene Expression Section, National Institute on Aging, National Institutes of Health, Maryland, United States of America.
Kaganovich A; Cell Biology and Gene Expression Section, National Institute on Aging, National Institutes of Health, Maryland, United States of America.
Ghosh MC; Molecular Medicine Branch, 'Eunice Kennedy Shriver' National Institute of Child Health and Human Development, Bethesda, Maryland, United States of America.
Pellegrini L; MRC Laboratory of Molecular Biology, Cambridge, United Kingdom.
Kumaran R; Cell Biology and Gene Expression Section, National Institute on Aging, National Institutes of Health, Maryland, United States of America.
Papazoglou I; National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America.
Heaton GR; Cell Biology and Gene Expression Section, National Institute on Aging, National Institutes of Health, Maryland, United States of America.
Bandopadhyay R; UCL Institute of Neurology and Reta Lila Weston Institute of Neurological Studies, University College London, London, United Kingdom.
Maio N; Molecular Medicine Branch, 'Eunice Kennedy Shriver' National Institute of Child Health and Human Development, Bethesda, Maryland, United States of America.
Kim C; Molecular Neuropathology Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America.
LaVoie MJ; Department of Neurology, University of Florida, Gainesville, Florida, United States of America.
Gershlick DC; Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom.
Cookson MR; Cell Biology and Gene Expression Section, National Institute on Aging, National Institutes of Health, Maryland, United States of America.
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Źródło:
PLoS biology [PLoS Biol] 2021 Dec 16; Vol. 19 (12), pp. e3001480. Date of Electronic Publication: 2021 Dec 16 (Print Publication: 2021).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Leucine-Rich Repeat Serine-Threonine Protein Kinase-2/*genetics
rab GTP-Binding Proteins/*metabolism
Aged ; Animals ; Biological Transport ; Corpus Striatum ; Gain of Function Mutation/genetics ; HEK293 Cells ; Humans ; Iron/metabolism ; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2/metabolism ; Lysosomes/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Microglia ; Middle Aged ; Mutation ; Parkinson Disease/genetics ; Parkinson Disease/metabolism ; Protein Serine-Threonine Kinases ; Transferrin/metabolism ; Transferrins/genetics ; Transferrins/metabolism ; rab GTP-Binding Proteins/genetics
Czasopismo naukowe

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