Temat: "leukemia" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: Cryptic KMT2A/MLLT10 fusion detected by next-generation sequencing in a case of pediatric acute megakaryoblastic leukemia.
Autorzy:: Kim Y; Department of Laboratory Medicine, Seoul National University Hospital, 101, Daehak-ro, Jongno-gu, Seoul 03080, Republic of Korea.
Kim B; Department of Laboratory Medicine, Seoul National University Hospital, 101, Daehak-ro, Jongno-gu, Seoul 03080, Republic of Korea.
Seong MW; Department of Laboratory Medicine, Seoul National University Hospital, 101, Daehak-ro, Jongno-gu, Seoul 03080, Republic of Korea; Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea; Seoul National University Cancer Research Institute, Seoul, Republic of Korea.
Lee DS; Department of Laboratory Medicine, Seoul National University Hospital, 101, Daehak-ro, Jongno-gu, Seoul 03080, Republic of Korea; Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea; Seoul National University Cancer Research Institute, Seoul, Republic of Korea.
Hong KT; Seoul National University Cancer Research Institute, Seoul, Republic of Korea; Department of Pediatrics, Seoul National University Children's Hospital, Seoul, Republic of Korea; Department of Pediatrics, Seoul National University College of Medicine, Seoul, Republic of Korea.
Kang HJ; Seoul National University Cancer Research Institute, Seoul, Republic of Korea; Department of Pediatrics, Seoul National University Children's Hospital, Seoul, Republic of Korea; Department of Pediatrics, Seoul National University College of Medicine, Seoul, Republic of Korea.
Yun J; Department of Laboratory Medicine, Seoul National University Hospital, 101, Daehak-ro, Jongno-gu, Seoul 03080, Republic of Korea; Department of Laboratory Medicine, Chung-Ang University Hospital, 102, Heukseok-ro, Dongjak-gu, Seoul 06973, Republic of Korea. Electronic address: .
Chang YH; Department of Laboratory Medicine, Seoul National University Hospital, 101, Daehak-ro, Jongno-gu, Seoul 03080, Republic of Korea; Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea. Electronic address: .; Pokaż więcej
Źródło:: Cancer genetics [Cancer Genet] 2023 Aug; Vol. 276-277, pp. 36-39. Date of Electronic Publication: 2023 Jul 11.
Typ publikacji:: Case Reports; Journal Article
MeSH Terms:: Leukemia, Megakaryoblastic, Acute*/genetics
Leukemia, Myeloid, Acute*/genetics
Child ; Humans ; In Situ Hybridization, Fluorescence ; Transcription Factors/genetics ; Myeloid-Lymphoid Leukemia Protein/genetics ; Translocation, Genetic ; High-Throughput Nucleotide Sequencing ; Oncogene Proteins, Fusion/genetics

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Szczegóły

Skocz do pozycji: 2.

Tytuł:: System analysis of Huang-Lian-Jie-Du-Tang and their key active ingredients for overcoming CML resistance by suppression of leukemia stem cells.
Autorzy:: Huang G; Department of Biochemistry and Molecular Biology, Medical College of Jinan University, Guangzhou 510632, China; Guangdong Engineering Technology Research Center of Drug Development for Small Nucleic Acids, Guangzhou 510632, China; Antisense Biopharmaceutical Technology Company, Limited, Guangzhou 510632, China.
Yin Z; Department of Biochemistry and Molecular Biology, Medical College of Jinan University, Guangzhou 510632, China; Guangdong Engineering Technology Research Center of Drug Development for Small Nucleic Acids, Guangzhou 510632, China; Antisense Biopharmaceutical Technology Company, Limited, Guangzhou 510632, China; Department of Hematology, Guangdong Second Provincial General Hospital, Jinan university, Guangdong, Guangzhou 510317, China.
Wang X; Department of Biochemistry and Molecular Biology, Medical College of Jinan University, Guangzhou 510632, China; Guangdong Engineering Technology Research Center of Drug Development for Small Nucleic Acids, Guangzhou 510632, China; Antisense Biopharmaceutical Technology Company, Limited, Guangzhou 510632, China.
Wen Z; Department of Biochemistry and Molecular Biology, Medical College of Jinan University, Guangzhou 510632, China; Guangdong Engineering Technology Research Center of Drug Development for Small Nucleic Acids, Guangzhou 510632, China; Antisense Biopharmaceutical Technology Company, Limited, Guangzhou 510632, China.
Su R; Department of Biochemistry and Molecular Biology, Medical College of Jinan University, Guangzhou 510632, China; Guangdong Engineering Technology Research Center of Drug Development for Small Nucleic Acids, Guangzhou 510632, China; Antisense Biopharmaceutical Technology Company, Limited, Guangzhou 510632, China.
Li C; Department of Biochemistry and Molecular Biology, Medical College of Jinan University, Guangzhou 510632, China; Guangdong Engineering Technology Research Center of Drug Development for Small Nucleic Acids, Guangzhou 510632, China; Antisense Biopharmaceutical Technology Company, Limited, Guangzhou 510632, China.
Liu Y; Department of Biochemistry and Molecular Biology, Medical College of Jinan University, Guangzhou 510632, China; Guangdong Engineering Technology Research Center of Drug Development for Small Nucleic Acids, Guangzhou 510632, China; Antisense Biopharmaceutical Technology Company, Limited, Guangzhou 510632, China.
Yang J; Department of Biochemistry and Molecular Biology, Medical College of Jinan University, Guangzhou 510632, China; Guangdong Engineering Technology Research Center of Drug Development for Small Nucleic Acids, Guangzhou 510632, China; Antisense Biopharmaceutical Technology Company, Limited, Guangzhou 510632, China.
Hu H; Department of Oncology, Sixth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China. Electronic address: .
Nie H; International Cooperative Laboratory of Traditional Chinese Medicine Modernization andInnovative Drug Development of Chinese Ministry of Education (MOE), College of Pharmacy, Jinan University, Guangzhou 510632, China; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 510632, China. Electronic address: .
Zeng X; Center Lab of Longhua Branch, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University), Guangdong, Shenzhen 518020, China. Electronic address: .
Fei J; Department of Biochemistry and Molecular Biology, Medical College of Jinan University, Guangzhou 510632, China; Guangdong Engineering Technology Research Center of Drug Development for Small Nucleic Acids, Guangzhou 510632, China; Antisense Biopharmaceutical Technology Company, Limited, Guangzhou 510632, China. Electronic address: .; Pokaż więcej
Źródło:: Phytomedicine : international journal of phytotherapy and phytopharmacology [Phytomedicine] 2023 Aug; Vol. 117, pp. 154918. Date of Electronic Publication: 2023 Jun 09.
Typ publikacji:: Journal Article
MeSH Terms:: Berberine*/pharmacology
Leukemia, Myelogenous, Chronic, BCR-ABL Positive*/drug therapy
Leukemia, Myelogenous, Chronic, BCR-ABL Positive*/genetics
Leukemia, Myelogenous, Chronic, BCR-ABL Positive*/metabolism
Leukemia, Myeloid, Acute*/drug therapy
Humans ; Mice ; Animals ; Imatinib Mesylate/pharmacology ; Imatinib Mesylate/therapeutic use ; Fusion Proteins, bcr-abl/genetics ; Fusion Proteins, bcr-abl/metabolism ; Myeloid Cell Leukemia Sequence 1 Protein ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/therapeutic use ; Drug Resistance, Neoplasm ; Stem Cells

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Skocz do pozycji: 3.

Tytuł:: Infrequent erythrophagocytosis by leukemic blasts in de novo T-lymphoblastic leukemia with SIL-TAL1: A rare pediatric case.
Autorzy:: Li T; Department of Laboratory Medicine, Beijing Ludaopei Hospital, Beijing, China.
Su L; Department of Minimally Invasive Oncology, The District People's Hospital of Zhangqiu, Jinan, Shandong, China.
Li X; Department of Health Ward, The District People's Hospital of Zhangqiu, Jinan, Shandong, China.
Zhang Y; Department of Clinical Laboratory, The District People's Hospital of Zhangqiu, Jinan, Shandong, China.
Li L; Department of Clinical Laboratory, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.
Zhu J; Department of Clinical Laboratory, The Fifth People's Hospital of Jinan, Jinan, Shandong, China.; Pokaż więcej
Źródło:: Pediatric blood & cancer [Pediatr Blood Cancer] 2023 Oct; Vol. 70 (10), pp. e30544. Date of Electronic Publication: 2023 Jul 05.
Typ publikacji:: Case Reports; Letter
MeSH Terms:: Precursor Cell Lymphoblastic Leukemia-Lymphoma*
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma*
Child ; Humans ; Basic Helix-Loop-Helix Transcription Factors ; Oncogene Proteins, Fusion ; T-Cell Acute Lymphocytic Leukemia Protein 1

Raport

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Szczegóły

Skocz do pozycji: 4.

Tytuł:: ZBTB16::RARA variant acute promyelocytic leukemia (vAPL) treated with gemtuzumab ozogamicin (GO) with unique pathology and genetic findings.
Autorzy:: Kassem AM; Center for Human Genetics, University Hospitals Cleveland Medical Center.; Clinical Pathology Department, Faculty of Medicine, Assiut University, Egypt.
Keinath MC; Center for Human Genetics, University Hospitals Cleveland Medical Center.; Department of Pathology, University Hospitals Cleveland Medical Center.
Adler JA; Case Western Reserve University School of Medicine.; Department of Hematology, University Hospitals Cleveland Medical Center.
Gadde R; Department of Pathology, University Hospitals Cleveland Medical Center.; Case Western Reserve University School of Medicine.
Tomlinson BK; Case Western Reserve University School of Medicine.; Department of Hematology, University Hospitals Cleveland Medical Center.
Shetty S; Center for Human Genetics, University Hospitals Cleveland Medical Center.; Department of Pathology, University Hospitals Cleveland Medical Center.; Case Western Reserve University School of Medicine.; Pokaż więcej
Źródło:: British journal of haematology [Br J Haematol] 2023 Sep; Vol. 202 (6), pp. 1077-1078. Date of Electronic Publication: 2023 Jul 26.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Leukemia, Promyelocytic, Acute*/drug therapy
Leukemia, Promyelocytic, Acute*/genetics
Leukemia, Promyelocytic, Acute*/pathology
Leukemia, Myeloid, Acute*
Humans ; Gemtuzumab/therapeutic use ; Antibodies, Monoclonal, Humanized/therapeutic use ; Antibodies, Monoclonal ; Aminoglycosides ; Promyelocytic Leukemia Zinc Finger Protein

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Skocz do pozycji: 5.

Tytuł:: The YEATS domain epigenetic reader proteins ENL and AF9 and their therapeutic value in leukemia.
Autorzy:: Hu H; Department of Pathology, University of Michigan Medical School, Ann Arbor, MI.
Muntean AG; Department of Pathology, University of Michigan Medical School, Ann Arbor, MI. Electronic address: .; Pokaż więcej
Źródło:: Experimental hematology [Exp Hematol] 2023 Aug; Vol. 124, pp. 15-21. Date of Electronic Publication: 2023 Jun 07.
Typ publikacji:: Journal Article; Review; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:: Transcription Factors*/genetics
Leukemia*/drug therapy
Leukemia*/genetics
Leukemia*/metabolism
Humans ; Histones/metabolism ; Myeloid-Lymphoid Leukemia Protein/genetics ; Myeloid-Lymphoid Leukemia Protein/metabolism ; Protein Domains ; Epigenesis, Genetic ; Oncogene Proteins, Fusion/genetics ; Oncogene Proteins, Fusion/metabolism

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Szczegóły

Skocz do pozycji: 6.

Tytuł:: Targeting the undruggable: menin inhibitors ante portas.
Autorzy:: Dempke WCM; University of Munich, Campus Grosshadern, Medical Clinic III, Marchioninistrasse 15, 81377, Munich, Germany. .; Haematology and Oncology, Carl Thiem Clinic, Cottbus, Germany. .
Desole M; Haematology and Oncology, Carl Thiem Clinic, Cottbus, Germany.
Chiusolo P; Haematology, Gemelli University Clinic, Rome, Italy.
Sica S; Haematology, Gemelli University Clinic, Rome, Italy.
Schmidt-Hieber M; Haematology and Oncology, Carl Thiem Clinic, Cottbus, Germany.; Pokaż więcej
Źródło:: Journal of cancer research and clinical oncology [J Cancer Res Clin Oncol] 2023 Sep; Vol. 149 (11), pp. 9451-9459. Date of Electronic Publication: 2023 Apr 27.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Neoplasm Recurrence, Local*
Leukemia, Myeloid, Acute*/drug therapy
Leukemia, Myeloid, Acute*/genetics
Humans ; Myeloid-Lymphoid Leukemia Protein/genetics ; Transcription Factors ; Nuclear Proteins/genetics

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Skocz do pozycji: 7.

Tytuł:: Dose-dependent expression of GFI1 alters metabolism in the haematopoietic progenitors and MLL::AF9-induced leukaemic cells.
Autorzy:: Patnana PK; Department of Medicine A, Hematology, Oncology and Pneumology, University Hospital Muenster, Muenster, Germany.; Department of Hematology and Stem Cell Transplantation, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.; Department of Hematology and Oncology, University Hospital of Schleswig-Holstein, University of Lübeck, Lübeck, Germany.
Liu L; Department of Medicine A, Hematology, Oncology and Pneumology, University Hospital Muenster, Muenster, Germany.; Department of Hematology, First Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Frank D; Department of Medicine A, Hematology, Oncology and Pneumology, University Hospital Muenster, Muenster, Germany.; Department of Hematology and Stem Cell Transplantation, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Nimmagadda SC; Department of Medicine A, Hematology, Oncology and Pneumology, University Hospital Muenster, Muenster, Germany.; Department of Hematology and Oncology, University Hospital of Schleswig-Holstein, University of Lübeck, Lübeck, Germany.
Behrens M; Institute of Food Chemistry, University of Muenster, Muenster, Germany.
Ahmed H; Department of Medicine A, Hematology, Oncology and Pneumology, University Hospital Muenster, Muenster, Germany.; Department of Hematology and Oncology, University Hospital of Schleswig-Holstein, University of Lübeck, Lübeck, Germany.
Xie X; Department of Medicine A, Hematology, Oncology and Pneumology, University Hospital Muenster, Muenster, Germany.; Department of Hematology-Oncology, Chongqing University Cancer Hospital, Chongqing, China.
Liebmann M; Department of Neurology with Institute of Translational Neurology, University Hospital Muenster, Muenster, Germany.
Wei L; Department of Medicine A, Hematology, Oncology and Pneumology, University Hospital Muenster, Muenster, Germany.; Institute of Medical Informatics, University of Muenster, Muenster, Germany.
Gerdemann A; Institute of Food Chemistry, University of Muenster, Muenster, Germany.
Thivakaran A; Clinic for Pediatrics III, University Hospital Essen, Essen, Germany.
Humpf HU; Institute of Food Chemistry, University of Muenster, Muenster, Germany.
Klotz L; Department of Neurology with Institute of Translational Neurology, University Hospital Muenster, Muenster, Germany.
Dugas M; Institute of Medical Informatics, Heidelberg University Hospital, Heidelberg, Germany.
Varghese J; Institute of Medical Informatics, University of Muenster, Muenster, Germany.
Trajkovic-Arsic M; Bridge Institute of Experimental Tumor Therapy, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.; Division of Solid Tumor Translational Oncology, German Cancer Consortium (DKTK Partner Site Essen) and German Cancer Research Center, DKFZ, Heidelberg, Germany.
Siveke JT; Bridge Institute of Experimental Tumor Therapy, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.; Division of Solid Tumor Translational Oncology, German Cancer Consortium (DKTK Partner Site Essen) and German Cancer Research Center, DKFZ, Heidelberg, Germany.
Hanenberg H; Clinic for Pediatrics III, University Hospital Essen, Essen, Germany.; Pediatric Oncology, Hematology & Immunology, Heinrich Heine University, University Hospital Düsseldorf, Dusseldorf, Germany.
Opalka B; Department of Hematology and Stem Cell Transplantation, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Dührsen U; Department of Hematology and Stem Cell Transplantation, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Reinhardt HC; Department of Hematology and Stem Cell Transplantation, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Guenther U; Institute of Chemistry and Metabolomics, University of Lübeck, Lübeck, Germany.
von Bubnoff N; Department of Hematology and Oncology, University Hospital of Schleswig-Holstein, University of Lübeck, Lübeck, Germany.
Khandanpour C; Department of Medicine A, Hematology, Oncology and Pneumology, University Hospital Muenster, Muenster, Germany.; Department of Hematology and Stem Cell Transplantation, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.; Department of Hematology and Oncology, University Hospital of Schleswig-Holstein, University of Lübeck, Lübeck, Germany.; Pokaż więcej
Źródło:: British journal of haematology [Br J Haematol] 2023 Sep; Vol. 202 (5), pp. 1033-1048. Date of Electronic Publication: 2023 Jul 09.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Transcription Factors*/genetics
Transcription Factors*/metabolism
Leukemia, Myeloid, Acute*/genetics
Leukemia, Myeloid, Acute*/metabolism
Humans ; Mice ; Animals ; Cell Differentiation ; Prognosis ; Epigenesis, Genetic ; Myeloid-Lymphoid Leukemia Protein/genetics ; Oncogene Proteins, Fusion/metabolism ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism

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Szczegóły

Skocz do pozycji: 8.

Tytuł:: MLL-AF4 cooperates with PAF1 and FACT to drive high-density enhancer interactions in leukemia.
Autorzy:: Crump NT; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DS, UK. .; Hugh and Josseline Langmuir Centre for Myeloma Research, Centre for Haematology, Department of Immunology and Inflammation, Imperial College London, London, W12 0NN, UK. .
Smith AL; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DS, UK.
Godfrey L; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DS, UK.
Dopico-Fernandez AM; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DS, UK.
Denny N; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DS, UK.
Harman JR; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DS, UK.
Hamley JC; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DS, UK.
Jackson NE; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DS, UK.
Chahrour C; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DS, UK.
Riva S; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DS, UK.
Rice S; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DS, UK.
Kim J; Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, 34141, South Korea.
Basrur V; Department of Pathology, University of Michigan, Ann Arbor, Michigan, USA.
Fermin D; Department of Pathology, University of Michigan, Ann Arbor, Michigan, USA.
Elenitoba-Johnson K; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Roeder RG; Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, NY, 10065, USA.
Allis CD; Laboratory of Chromatin Biology and Epigenetics, The Rockefeller University, New York, NY, 10065, USA.
Roberts I; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DS, UK.; Department of Paediatrics, University of Oxford, Oxford, OX3 9DU, UK.
Roy A; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DS, UK.; Department of Paediatrics, University of Oxford, Oxford, OX3 9DU, UK.
Geng H; Department of Laboratory Medicine, University of California, San Francisco, San Francisco, California, USA.
Davies JOJ; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DS, UK.
Milne TA; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DS, UK. .; Pokaż więcej
Źródło:: Nature communications [Nat Commun] 2023 Aug 25; Vol. 14 (1), pp. 5208. Date of Electronic Publication: 2023 Aug 25.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Nuclear Proteins*/genetics
Leukemia*/genetics
Humans ; Transcription Factors/genetics ; Regulatory Sequences, Nucleic Acid ; Promoter Regions, Genetic/genetics ; Cell Cycle Proteins ; Oncogene Proteins, Fusion/genetics ; Myeloid-Lymphoid Leukemia Protein/genetics

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Skocz do pozycji: 9.

Tytuł:: Prevalence of Different Courses of Feline Leukaemia Virus Infection in Four European Countries.
Autorzy:: Giselbrecht J; LMU Small Animal Clinic, Centre for Clinical Veterinary Medicine, 80539 Munich, Germany.
Jähne S; LMU Small Animal Clinic, Centre for Clinical Veterinary Medicine, 80539 Munich, Germany.
Bergmann M; LMU Small Animal Clinic, Centre for Clinical Veterinary Medicine, 80539 Munich, Germany.
Meli ML; Clinical Laboratory, Department of Clinical Diagnostics and Services, and Centre for Clinical Studies, Vetsuisse Faculty, University of Zurich, 8057 Zurich, Switzerland.
Pineroli B; Clinical Laboratory, Department of Clinical Diagnostics and Services, and Centre for Clinical Studies, Vetsuisse Faculty, University of Zurich, 8057 Zurich, Switzerland.
Boenzli E; Clinical Laboratory, Department of Clinical Diagnostics and Services, and Centre for Clinical Studies, Vetsuisse Faculty, University of Zurich, 8057 Zurich, Switzerland.
Teichmann-Knorrn S; Veterinary Clinic Oberhaching, 82041 Oberhaching, Germany.
Zablotski Y; LMU Small Animal Clinic, Centre for Clinical Veterinary Medicine, 80539 Munich, Germany.
Pennisi MG; Department of Veterinary Sciences, University of Messina, 98168 Messina, Italy.
Layachi N; Layachi Veterinary Clinic, 33300 Bordeaux, France.
Serra R; Investigacao Veterinaria Independente, 1700-119 Lisbon, Portugal.
Bo S; Ambulatorio Veterinario Bo-Ferro, 10123 Turin, Italy.
Hofmann-Lehmann R; Clinical Laboratory, Department of Clinical Diagnostics and Services, and Centre for Clinical Studies, Vetsuisse Faculty, University of Zurich, 8057 Zurich, Switzerland.
Hartmann K; LMU Small Animal Clinic, Centre for Clinical Veterinary Medicine, 80539 Munich, Germany.; Pokaż więcej
Źródło:: Viruses [Viruses] 2023 Aug 10; Vol. 15 (8). Date of Electronic Publication: 2023 Aug 10.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Leukemia, Feline*
Focal Infection*
Cats ; Animals ; Leukemia Virus, Feline ; Prevalence ; Europe/epidemiology ; Italy/epidemiology ; Proviruses

Czasopismo naukowe

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Pełny tekst Pełny tekst Szczegóły

Skocz do pozycji: 10.

Tytuł:: Feline osteochondromatosis in a 12-year-old feline leukaemia virus-negative cat.
Autorzy:: Gómez Á; Department of Animal Pathology, Veterinary Faculty, University of Zaragoza, 117 Miguel Servet Street, 50013 Zaragoza, Spain.
Rodríguez-Largo A; Department of Animal Pathology, Veterinary Faculty, University of Zaragoza, 117 Miguel Servet Street, 50013 Zaragoza, Spain.
Pérez E; Department of Animal Pathology, Veterinary Faculty, University of Zaragoza, 117 Miguel Servet Street, 50013 Zaragoza, Spain.
Calvo-Sánchez N; Department of Animal Pathology, Veterinary Faculty, University of Zaragoza, 117 Miguel Servet Street, 50013 Zaragoza, Spain.
Loomans S; Department of Veterinary Pathology, Veterinary Faculty, University of Ghent, Campus Merelbeke, Salisburylaan 133, 9820 Merelbeke, Ghent, Belgium.
Chiers K; Department of Veterinary Pathology, Veterinary Faculty, University of Ghent, Campus Merelbeke, Salisburylaan 133, 9820 Merelbeke, Ghent, Belgium.
Monteagudo L; Department of Anatomy, Embryology and Animal Genetics, Veterinary Faculty, University of Zaragoza, 177 Miguel Servet Street, 50013 Zaragoza, Spain.
Luján L; Department of Animal Pathology, Veterinary Faculty, University of Zaragoza, 117 Miguel Servet Street, 50013 Zaragoza, Spain.
Pérez M; Department of Anatomy, Embryology and Animal Genetics, Veterinary Faculty, University of Zaragoza, 177 Miguel Servet Street, 50013 Zaragoza, Spain. Electronic address: .; Pokaż więcej
Źródło:: Journal of comparative pathology [J Comp Pathol] 2023 Aug; Vol. 205, pp. 24-26. Date of Electronic Publication: 2023 Aug 17.
Typ publikacji:: Journal Article
MeSH Terms:: Osteochondromatosis*/veterinary
Leukemia, Feline*
Ankylosis*/veterinary
Cat Diseases*
Female ; Cats ; Animals ; Leukemia Virus, Feline ; Exons

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Skocz do pozycji: 11.

Tytuł:: Having it both ways: how STAT3 deficiency blocks graft-versus-host disease while preserving graft-versus-leukemia activity.
Autorzy:: Brandstadter JD
Outen R
Maillard I; Pokaż więcej
Źródło:: The Journal of clinical investigation [J Clin Invest] 2023 Aug 01; Vol. 133 (15). Date of Electronic Publication: 2023 Aug 01.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:: Graft vs Host Disease*/genetics
Graft vs Host Disease*/therapy
Leukemia*/pathology
Hematopoietic Stem Cell Transplantation*
Humans ; T-Lymphocytes ; Graft vs Leukemia Effect ; STAT3 Transcription Factor/genetics

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Szczegóły

Skocz do pozycji: 12.

Tytuł:: A new breakpoint fusion gene involving KMT2A::EDC4 rearrangement in de novo acute myeloid leukemia.
Autorzy:: Hu DY; National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Wang M; National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Shen K; National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Pan JL; Institute of Blood and Marrow Transplantation, Collaborative Innovation Center of Hematology, Soochow University, Suzhou, China.
Guo YS; Institute of Blood and Marrow Transplantation, Collaborative Innovation Center of Hematology, Soochow University, Suzhou, China.
Zhang ZB; Institute of Blood and Marrow Transplantation, Collaborative Innovation Center of Hematology, Soochow University, Suzhou, China.
Zhang FH; Institute of Blood and Marrow Transplantation, Collaborative Innovation Center of Hematology, Soochow University, Suzhou, China.
Yin J; National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China.; Institute of Blood and Marrow Transplantation, Collaborative Innovation Center of Hematology, Soochow University, Suzhou, China.
Chen SN; National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China.; Institute of Blood and Marrow Transplantation, Collaborative Innovation Center of Hematology, Soochow University, Suzhou, China.; Pokaż więcej
Źródło:: International journal of laboratory hematology [Int J Lab Hematol] 2023 Aug; Vol. 45 (4), pp. 596-598. Date of Electronic Publication: 2023 Feb 21.
Typ publikacji:: Letter; Comment
MeSH Terms:: Leukemia, Myeloid, Acute*/genetics
Humans ; Myeloid-Lymphoid Leukemia Protein/genetics ; Gene Rearrangement ; Proteins/genetics

Opinia redakcyjna

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Szczegóły

Skocz do pozycji: 13.

Tytuł:: Donor T cell STAT3 deficiency enables tissue PD-L1-dependent prevention of graft-versus-host disease while preserving graft-versus-leukemia activity.
Autorzy:: Li Q; Medical Center of Hematology, Xinqiao Hospital, State Key Laboratory of Trauma, Burn and Combined Injury, Army Medical University, Chongqing, China.; Arthur D. Riggs Diabetes and Metabolism Research Institute, The Beckman Research Institute of City of Hope, Duarte, California, USA.; Hematologic Malignancies and Stem Cell Transplantation Institute, City of Hope National Medical Center, Duarte, California, USA.
Wang X; Medical Center of Hematology, Xinqiao Hospital, State Key Laboratory of Trauma, Burn and Combined Injury, Army Medical University, Chongqing, China.; Arthur D. Riggs Diabetes and Metabolism Research Institute, The Beckman Research Institute of City of Hope, Duarte, California, USA.; Hematologic Malignancies and Stem Cell Transplantation Institute, City of Hope National Medical Center, Duarte, California, USA.
Song Q; Arthur D. Riggs Diabetes and Metabolism Research Institute, The Beckman Research Institute of City of Hope, Duarte, California, USA.; Hematologic Malignancies and Stem Cell Transplantation Institute, City of Hope National Medical Center, Duarte, California, USA.; Fujian Medical University Center of Translational Hematology, Fujian Institute of Hematology, and Fujian Medical University Union Hospital, Fuzhou, China.
Yang S; Medical Center of Hematology, Xinqiao Hospital, State Key Laboratory of Trauma, Burn and Combined Injury, Army Medical University, Chongqing, China.; Arthur D. Riggs Diabetes and Metabolism Research Institute, The Beckman Research Institute of City of Hope, Duarte, California, USA.; Hematologic Malignancies and Stem Cell Transplantation Institute, City of Hope National Medical Center, Duarte, California, USA.
Wu X; Department of Computational and Quantitative Medicine, Beckman Research Institute of City of Hope, Duarte, California, USA.
Yang D; Department of Computational and Quantitative Medicine, Beckman Research Institute of City of Hope, Duarte, California, USA.
Marié IJ; Department of Pathology, NYU Grossman School of Medicine, New York, USA.
Qin H; Department of Computational and Quantitative Medicine, Beckman Research Institute of City of Hope, Duarte, California, USA.
Zheng M; Arthur D. Riggs Diabetes and Metabolism Research Institute, The Beckman Research Institute of City of Hope, Duarte, California, USA.; Hematologic Malignancies and Stem Cell Transplantation Institute, City of Hope National Medical Center, Duarte, California, USA.
Nasri U; Arthur D. Riggs Diabetes and Metabolism Research Institute, The Beckman Research Institute of City of Hope, Duarte, California, USA.; Hematologic Malignancies and Stem Cell Transplantation Institute, City of Hope National Medical Center, Duarte, California, USA.
Kong X; Arthur D. Riggs Diabetes and Metabolism Research Institute, The Beckman Research Institute of City of Hope, Duarte, California, USA.; Hematologic Malignancies and Stem Cell Transplantation Institute, City of Hope National Medical Center, Duarte, California, USA.
Wang B; Arthur D. Riggs Diabetes and Metabolism Research Institute, The Beckman Research Institute of City of Hope, Duarte, California, USA.; Hematologic Malignancies and Stem Cell Transplantation Institute, City of Hope National Medical Center, Duarte, California, USA.; Fujian Medical University Center of Translational Hematology, Fujian Institute of Hematology, and Fujian Medical University Union Hospital, Fuzhou, China.
Lizhar E; Arthur D. Riggs Diabetes and Metabolism Research Institute, The Beckman Research Institute of City of Hope, Duarte, California, USA.
Cassady K; Arthur D. Riggs Diabetes and Metabolism Research Institute, The Beckman Research Institute of City of Hope, Duarte, California, USA.; Hematologic Malignancies and Stem Cell Transplantation Institute, City of Hope National Medical Center, Duarte, California, USA.
Tompkins J; Arthur D. Riggs Diabetes and Metabolism Research Institute, The Beckman Research Institute of City of Hope, Duarte, California, USA.
Levy D; Department of Pathology, NYU Grossman School of Medicine, New York, USA.
Martin PJ; Fred Hutchinson Cancer Center, Seattle, Washington, USA.
Zhang X; Medical Center of Hematology, Xinqiao Hospital, State Key Laboratory of Trauma, Burn and Combined Injury, Army Medical University, Chongqing, China.
Zeng D; Arthur D. Riggs Diabetes and Metabolism Research Institute, The Beckman Research Institute of City of Hope, Duarte, California, USA.; Hematologic Malignancies and Stem Cell Transplantation Institute, City of Hope National Medical Center, Duarte, California, USA.; Pokaż więcej
Źródło:: The Journal of clinical investigation [J Clin Invest] 2023 Aug 01; Vol. 133 (15). Date of Electronic Publication: 2023 Aug 01.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:: Graft vs Host Disease*/genetics
Graft vs Host Disease*/prevention & control
Leukemia*
Mice ; Animals ; B7-H1 Antigen/genetics ; B7-H1 Antigen/metabolism ; Programmed Cell Death 1 Receptor/metabolism ; T-Lymphocytes/metabolism ; Graft vs Leukemia Effect/genetics ; Bone Marrow Transplantation
SCR Disease Name:: Thymic aplasia

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Szczegóły

Skocz do pozycji: 14.

Tytuł:: Circular RNAs drive oncogenic chromosomal translocations within the MLL recombinome in leukemia.
Autorzy:: Conn VM; Flinders Health and Medical Research Institute, College of Medicine & Public Health, Flinders University, Bedford Park, SA 5042, Australia; Centre for Cancer Biology, SA Pathology & University of South Australia, Adelaide, SA 5000, Australia.
Gabryelska M; Flinders Health and Medical Research Institute, College of Medicine & Public Health, Flinders University, Bedford Park, SA 5042, Australia.
Toubia J; Centre for Cancer Biology, SA Pathology & University of South Australia, Adelaide, SA 5000, Australia; ACRF Cancer Genomics Facility, SA Pathology, Adelaide, SA 5000, Australia.
Kirk K; Flinders Health and Medical Research Institute, College of Medicine & Public Health, Flinders University, Bedford Park, SA 5042, Australia.
Gantley L; Flinders Health and Medical Research Institute, College of Medicine & Public Health, Flinders University, Bedford Park, SA 5042, Australia.
Powell JA; Centre for Cancer Biology, SA Pathology & University of South Australia, Adelaide, SA 5000, Australia; Adelaide Medical School, Faculty of Health and Medical Sciences, the University of Adelaide, Adelaide, SA 5000, Australia.
Cildir G; Centre for Cancer Biology, SA Pathology & University of South Australia, Adelaide, SA 5000, Australia.
Marri S; Flinders Health and Medical Research Institute, College of Medicine & Public Health, Flinders University, Bedford Park, SA 5042, Australia.
Liu R; Flinders Health and Medical Research Institute, College of Medicine & Public Health, Flinders University, Bedford Park, SA 5042, Australia.
Stringer BW; Flinders Health and Medical Research Institute, College of Medicine & Public Health, Flinders University, Bedford Park, SA 5042, Australia.
Townley S; Flinders Health and Medical Research Institute, College of Medicine & Public Health, Flinders University, Bedford Park, SA 5042, Australia.
Webb ST; Flinders Health and Medical Research Institute, College of Medicine & Public Health, Flinders University, Bedford Park, SA 5042, Australia.
Lin H; Flinders Health and Medical Research Institute, College of Medicine & Public Health, Flinders University, Bedford Park, SA 5042, Australia.
Samaraweera SE; Centre for Cancer Biology, SA Pathology & University of South Australia, Adelaide, SA 5000, Australia.
Bailey S; Health and Biomedical Innovation, Clinical and Health Sciences, University of South Australia, Adelaide, SA 5000, Australia.
Moore AS; Child Health Research Centre, the University of Queensland, Brisbane, QLD 4101, Australia; Oncology Service, Children's Health Queensland Hospital and Health Service, Brisbane, QLD 4101, Australia.
Maybury M; Child Health Research Centre, the University of Queensland, Brisbane, QLD 4101, Australia.
Liu D; Centre for Cancer Biology, SA Pathology & University of South Australia, Adelaide, SA 5000, Australia.
Colella AD; Flinders Health and Medical Research Institute, College of Medicine & Public Health, Flinders University, Bedford Park, SA 5042, Australia; Flinders Omics Facility, College of Medicine & Public Health, Flinders University, Bedford Park, SA 5042, Australia.
Chataway T; Flinders Health and Medical Research Institute, College of Medicine & Public Health, Flinders University, Bedford Park, SA 5042, Australia; Flinders Omics Facility, College of Medicine & Public Health, Flinders University, Bedford Park, SA 5042, Australia.
Wallington-Gates CT; Flinders Health and Medical Research Institute, College of Medicine & Public Health, Flinders University, Bedford Park, SA 5042, Australia; Centre for Cancer Biology, SA Pathology & University of South Australia, Adelaide, SA 5000, Australia; Adelaide Medical School, Faculty of Health and Medical Sciences, the University of Adelaide, Adelaide, SA 5000, Australia; Flinders Medical Centre, Bedford Park, SA 5042, Australia.
Walters L; Adelaide Rural Clinical School, Faculty of Health and Medical Sciences, the University of Adelaide, Adelaide, SA 5000, Australia.
Sibbons J; Adelaide Microscopy, Division of Research and Innovation, University of Adelaide, Adelaide, SA 5000, Australia.
Selth LA; Flinders Health and Medical Research Institute, College of Medicine & Public Health, Flinders University, Bedford Park, SA 5042, Australia; Freemasons Centre for Male Health and Wellbeing, Flinders University, Bedford Park, SA 5042, Australia.
Tergaonkar V; Laboratory of NFκB Signalling, Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A(∗)STAR), 61 Biopolis Drive, Proteos, Singapore 138673, Republic of Singapore.
D'Andrea RJ; Centre for Cancer Biology, SA Pathology & University of South Australia, Adelaide, SA 5000, Australia.
Pitson SM; Centre for Cancer Biology, SA Pathology & University of South Australia, Adelaide, SA 5000, Australia; Adelaide Medical School, Faculty of Health and Medical Sciences, the University of Adelaide, Adelaide, SA 5000, Australia.
Goodall GJ; Centre for Cancer Biology, SA Pathology & University of South Australia, Adelaide, SA 5000, Australia; Adelaide Medical School, Faculty of Health and Medical Sciences, the University of Adelaide, Adelaide, SA 5000, Australia.
Conn SJ; Flinders Health and Medical Research Institute, College of Medicine & Public Health, Flinders University, Bedford Park, SA 5042, Australia; Centre for Cancer Biology, SA Pathology & University of South Australia, Adelaide, SA 5000, Australia. Electronic address: .; Pokaż więcej
Źródło:: Cancer cell [Cancer Cell] 2023 Jul 10; Vol. 41 (7), pp. 1309-1326.e10. Date of Electronic Publication: 2023 Jun 08.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Translocation, Genetic*
Leukemia*/genetics
Leukemia*/pathology
Animals ; Mice ; Humans ; RNA, Circular/genetics ; Myeloid-Lymphoid Leukemia Protein/genetics ; Myeloid-Lymphoid Leukemia Protein/metabolism ; DNA ; Oncogene Proteins, Fusion/genetics

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Szczegóły

Skocz do pozycji: 15.

Tytuł:: Progressive and regressive infection with feline leukemia virus (FeLV) in cats in southern Brazil: Prevalence, risk factors associated, clinical and hematologic alterations.
Autorzy:: Biezus G; Department of Veterinary Medicine, Universidade do Estado de Santa Catarina (UDESC), Av. Luís de Camões 2090, Lages, Santa Catarina, Brazil.
Grima de Cristo T; Department of Veterinary Medicine, Universidade do Estado de Santa Catarina (UDESC), Av. Luís de Camões 2090, Lages, Santa Catarina, Brazil.
da Silva Casa M; Department of Veterinary Medicine, Universidade do Estado de Santa Catarina (UDESC), Av. Luís de Camões 2090, Lages, Santa Catarina, Brazil.
Lovatel M; Department of Veterinary Medicine, Universidade do Estado de Santa Catarina (UDESC), Av. Luís de Camões 2090, Lages, Santa Catarina, Brazil.
Vavassori M; Department of Veterinary Medicine, Universidade do Estado de Santa Catarina (UDESC), Av. Luís de Camões 2090, Lages, Santa Catarina, Brazil.
Brüggemann de Souza Teixeira M; Department of Veterinary Medicine, Universidade do Estado de Santa Catarina (UDESC), Av. Luís de Camões 2090, Lages, Santa Catarina, Brazil.
Miletti LC; Department of Veterinary Medicine, Universidade do Estado de Santa Catarina (UDESC), Av. Luís de Camões 2090, Lages, Santa Catarina, Brazil.
Maciel da Costa U; Department of Veterinary Medicine, Universidade do Estado de Santa Catarina (UDESC), Av. Luís de Camões 2090, Lages, Santa Catarina, Brazil.
Assis Casagrande R; Department of Veterinary Medicine, Universidade do Estado de Santa Catarina (UDESC), Av. Luís de Camões 2090, Lages, Santa Catarina, Brazil. Electronic address: .; Pokaż więcej
Źródło:: Preventive veterinary medicine [Prev Vet Med] 2023 Jul; Vol. 216, pp. 105945. Date of Electronic Publication: 2023 May 16.
Typ publikacji:: Journal Article
MeSH Terms:: Immunodeficiency Virus, Feline*
Leukemia, Feline*/diagnosis
Leukemia*/veterinary
Lymphoma*/veterinary
Feline Acquired Immunodeficiency Syndrome*/epidemiology
Cat Diseases*/epidemiology
Cats ; Animals ; Male ; Leukemia Virus, Feline ; Prevalence ; Brazil/epidemiology ; Cross-Sectional Studies ; Risk Factors

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Szczegóły

Skocz do pozycji: 16.

Tytuł:: Prognostic factors of childhood acute lymphoblastic leukemia with TCF3::PBX1 in CCCG-ALL-2015: A multicenter study.
Autorzy:: Zhang H; Department of Hematology/Oncology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
Wan Y; Department of Pediatrics, State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.
Wang H; Department of Hematology/Oncology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
Cai J; Department of Hematology/Oncology, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, National Health Committee Key Laboratory of Pediatric Hematology & Oncology, Shanghai, China.
Yu J; Department of Hematology/Oncology, Chongqing Medical University Affiliated Children's Hospital, Chongqing, China.
Hu S; Department of Hematology/Oncology, Children's Hospital of Soochow University, Suzhou, China.
Fang Y; Department of Hematology/Oncology, Children's Hospital of Nanjing Medical University, Nanjing, China.
Gao J; Department of Pediatrics, West China Second University Hospital, Sichuan University, Key Laboratory of Birth Defects and Related Disease of Women and Children, Ministry of Education, Chengdu, China.
Jiang H; Department of Hematology/Oncology, Guangzhou Women and Children's Medical Center, Guangzhou, China.
Yang M; Department of Pediatrics, Xiangya Hospital Central South University, Changsha, China.
Liang C; Department of Hematology/Oncology, Jiangxi Provincial Children's Hospital, Nanchang, China.
Jin R; Department of Pediatrics, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Tian X; Department of Hematology/Oncology, KunMing Children's Hospital, Kunming, China.
Ju X; Department of Pediatrics, Qilu Hospital of Shandong University, Jinan, China.
Hu Q; Department of Pediatrics, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Jiang H; Department of Hematology/Oncology, Children's Hospital Affiliated to Shanghai Jiao Tong University, Shanghai, China.
Li Z; Department of Hematology/Oncology, Xi'an Northwest Women's and Children's Hospital, Xi'an, China.
Wang N; Department of Pediatrics, Anhui Medical University Second Affiliated Hospital, Hefei, Anhui, China.
Sun L; Department of Pediatrics, Affiliated Hospital of Qingdao University, Qingdao, China.
Leung AWK; Department of Pediatrics, Hong Kong Children's Hospital, The Chinese University of Hong Kong, Hong Kong, Hong Kong SAR, China.
Wu X; Department of Pediatrics, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Qian X; Department of Hematology/Oncology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
Qian M; Department of Hematology/Oncology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
Li CK; Department of Pediatrics, Hong Kong Children's Hospital, The Chinese University of Hong Kong, Hong Kong, Hong Kong SAR, China.
Yang J; Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.; Department of Global Pediatric Medicine, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.; Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Tang J; Department of Hematology/Oncology, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, National Health Committee Key Laboratory of Pediatric Hematology & Oncology, Shanghai, China.
Zhu X; Department of Pediatrics, State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.
Shen S; Department of Hematology/Oncology, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, National Health Committee Key Laboratory of Pediatric Hematology & Oncology, Shanghai, China.
Zhang L; Department of Pediatrics, State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.
Pui CH; Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.; Department of Global Pediatric Medicine, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.; Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Zhai X; Department of Hematology/Oncology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.; Pokaż więcej
Źródło:: Cancer [Cancer] 2023 Jun 01; Vol. 129 (11), pp. 1691-1703. Date of Electronic Publication: 2023 Mar 21.
Typ publikacji:: Multicenter Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Precursor Cell Lymphoblastic Leukemia-Lymphoma*/therapy
Precursor Cell Lymphoblastic Leukemia-Lymphoma*/drug therapy
Hematopoietic Stem Cell Transplantation*
Child ; Humans ; Male ; Female ; Prognosis ; Remission Induction ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Neoplasm, Residual/drug therapy ; Disease-Free Survival ; Pre-B-Cell Leukemia Transcription Factor 1 ; Basic Helix-Loop-Helix Transcription Factors/genetics

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Szczegóły

Skocz do pozycji: 17.

Tytuł:: AKT inhibition sensitizes acute leukemia cells to S63845-induced apoptosis.
Autorzy:: Li Y; Basic Medicine College, Anhui Medical University, Hefei, People's Republic of China.; Anhui Province Key Laboratory of Medical Physics and Technology, Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, People's Republic of China.; Hefei Cancer Hospital, Chinese Academy of Sciences, Hefei, People's Republic of China.
Du L; Basic Medicine College, Anhui Medical University, Hefei, People's Republic of China.; Anhui Province Key Laboratory of Medical Physics and Technology, Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, People's Republic of China.; Hefei Cancer Hospital, Chinese Academy of Sciences, Hefei, People's Republic of China.
Ye K; Anhui Province Key Laboratory of Medical Physics and Technology, Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, People's Republic of China.; Hefei Cancer Hospital, Chinese Academy of Sciences, Hefei, People's Republic of China.
Sun X; Anhui Province Key Laboratory of Medical Physics and Technology, Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, People's Republic of China.; Hefei Cancer Hospital, Chinese Academy of Sciences, Hefei, People's Republic of China.
Hu L; Anhui Province Key Laboratory of Medical Physics and Technology, Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, People's Republic of China.; Hefei Cancer Hospital, Chinese Academy of Sciences, Hefei, People's Republic of China.
Gao S; Basic Medicine College, Anhui Medical University, Hefei, People's Republic of China.
Dai H; Basic Medicine College, Anhui Medical University, Hefei, People's Republic of China.; Anhui Province Key Laboratory of Medical Physics and Technology, Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, People's Republic of China.; Hefei Cancer Hospital, Chinese Academy of Sciences, Hefei, People's Republic of China.; Pokaż więcej
Źródło:: Hematology (Amsterdam, Netherlands) [Hematology] 2023 Dec; Vol. 28 (1), pp. 2214465.
Typ publikacji:: Journal Article
MeSH Terms:: Proto-Oncogene Proteins c-akt*
Leukemia, Myeloid, Acute*
Humans ; Myeloid Cell Leukemia Sequence 1 Protein ; Apoptosis

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na półce

Szczegóły

Skocz do pozycji: 18.

Tytuł:: Design and optimization of selective and potent CDK9 inhibitors with flavonoid scaffold for the treatment of acute myeloid leukemia.
Autorzy:: Wu T; Jiangsu Key Laboratory of Drug Design and Optimization, Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, PR China.
Yu B; Jiangsu Key Laboratory of Drug Design and Optimization, Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, PR China.
Gong W; Jiangsu Key Laboratory of Drug Design and Optimization, Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, PR China.
Zhang J; Jiangsu Key Laboratory of Drug Design and Optimization, Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, PR China.
Yu S; Jiangsu Key Laboratory of Drug Design and Optimization, Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, PR China.
Tian Y; Jiangsu Key Laboratory of Drug Design and Optimization, Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, PR China.
Zhao T; Jiangsu Key Laboratory of Drug Design and Optimization, Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, PR China.
Li Z; Jiangsu Key Laboratory of Drug Design and Optimization, Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, PR China. Electronic address: .
Wang J; Jiangsu Key Laboratory of Drug Design and Optimization, Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, PR China. Electronic address: .
Bian J; Jiangsu Key Laboratory of Drug Design and Optimization, Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, PR China. Electronic address: .; Pokaż więcej
Źródło:: European journal of medicinal chemistry [Eur J Med Chem] 2023 Nov 05; Vol. 259, pp. 115711. Date of Electronic Publication: 2023 Aug 09.
Typ publikacji:: Journal Article
MeSH Terms:: Antineoplastic Agents*/pharmacology
Antineoplastic Agents*/therapeutic use
Leukemia, Myeloid, Acute*/pathology
Humans ; Flavonoids/pharmacology ; Flavonoids/therapeutic use ; Myeloid Cell Leukemia Sequence 1 Protein/metabolism ; Apoptosis ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/therapeutic use ; Cell Line, Tumor ; Cyclin-Dependent Kinase 9/metabolism

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na półce

Szczegóły

Skocz do pozycji: 19.

Tytuł:: PP2A modulation overcomes multidrug resistance in chronic lymphocytic leukemia via mPTP-dependent apoptosis.
Autorzy:: Jayappa KD; Department of Microbiology, Immunology, and Cancer Biology, University of Virginia (UVA) School of Medicine, Charlottesville, Virginia, USA.; Beirne B. Carter Center for Immunology Research, Charlottesville, Virginia, USA.; Department of Pharmacology, Charlottesville, Virginia, USA.
Tran B; Division of Genetic Medicine, Department of Internal Medicine, the University of Michigan, Ann Arbor, Michigan, USA.
Gordon VL; Department of Microbiology, Immunology, and Cancer Biology, University of Virginia (UVA) School of Medicine, Charlottesville, Virginia, USA.; Beirne B. Carter Center for Immunology Research, Charlottesville, Virginia, USA.
Morris C; Department of Microbiology, Immunology, and Cancer Biology, University of Virginia (UVA) School of Medicine, Charlottesville, Virginia, USA.; Beirne B. Carter Center for Immunology Research, Charlottesville, Virginia, USA.
Saha S; Department of Biochemistry and Molecular Genetics, Charlottesville, Virginia, USA.
Farrington CC; Division of Genetic Medicine, Department of Internal Medicine, the University of Michigan, Ann Arbor, Michigan, USA.
O'Connor CM; Division of Genetic Medicine, Department of Internal Medicine, the University of Michigan, Ann Arbor, Michigan, USA.
Zawacki KP; Division of Genetic Medicine, Department of Internal Medicine, the University of Michigan, Ann Arbor, Michigan, USA.
Isaac KM; Division of Hematology/Oncology, UVA School of Medicine, Charlottesville, Virginia, USA.
Kester M; Department of Pharmacology, Charlottesville, Virginia, USA.; Department of Biomedical Engineering, UVA, Charlottesville, Virginia, USA.
Bender TP; Department of Microbiology, Immunology, and Cancer Biology, University of Virginia (UVA) School of Medicine, Charlottesville, Virginia, USA.; Beirne B. Carter Center for Immunology Research, Charlottesville, Virginia, USA.
Williams ME; Division of Hematology/Oncology, UVA School of Medicine, Charlottesville, Virginia, USA.; Cancer Center, UVA, Charlottesville, Virginia, USA.
Portell CA; Division of Hematology/Oncology, UVA School of Medicine, Charlottesville, Virginia, USA.; Cancer Center, UVA, Charlottesville, Virginia, USA.
Weber MJ; Department of Microbiology, Immunology, and Cancer Biology, University of Virginia (UVA) School of Medicine, Charlottesville, Virginia, USA.; Beirne B. Carter Center for Immunology Research, Charlottesville, Virginia, USA.; Cancer Center, UVA, Charlottesville, Virginia, USA.
Narla G; Division of Genetic Medicine, Department of Internal Medicine, the University of Michigan, Ann Arbor, Michigan, USA.; Pokaż więcej
Źródło:: The Journal of clinical investigation [J Clin Invest] 2023 Jul 03; Vol. 133 (13). Date of Electronic Publication: 2023 Jul 03.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:: Leukemia, Lymphocytic, Chronic, B-Cell*/drug therapy
Leukemia, Lymphocytic, Chronic, B-Cell*/genetics
Leukemia, Lymphocytic, Chronic, B-Cell*/metabolism
Humans ; Animals ; Mice ; bcl-2-Associated X Protein/metabolism ; Protein Phosphatase 2/genetics ; Myeloid Cell Leukemia Sequence 1 Protein/metabolism ; Proto-Oncogene Proteins c-bcl-2 ; Apoptosis/physiology ; Apoptosis Regulatory Proteins/metabolism ; Drug Resistance, Multiple

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Szczegóły

Skocz do pozycji: 20.

Tytuł:: Isoforms of the TAL1 transcription factor have different roles in hematopoiesis and cell growth.
Autorzy:: Sharma A; Faculty of Medicine, Department of Biochemistry and Molecular Biology, The Institute for Medical Research Israel-Canada, The Hebrew University of Jerusalem, Jerusalem, Israel.
Mistriel-Zerbib S; Faculty of Medicine, The Lautenberg Center for Immunology and Cancer Research, The Institute for Medical Research Israel-Canada, The Hebrew University of Jerusalem, Jerusalem, Israel.
Najar RA; Faculty of Medicine, Department of Biochemistry and Molecular Biology, The Institute for Medical Research Israel-Canada, The Hebrew University of Jerusalem, Jerusalem, Israel.
Engal E; Faculty of Medicine, Department of Biochemistry and Molecular Biology, The Institute for Medical Research Israel-Canada, The Hebrew University of Jerusalem, Jerusalem, Israel.
Bentata M; Faculty of Medicine, Department of Biochemistry and Molecular Biology, The Institute for Medical Research Israel-Canada, The Hebrew University of Jerusalem, Jerusalem, Israel.
Taqatqa N; Faculty of Medicine, Department of Biochemistry and Molecular Biology, The Institute for Medical Research Israel-Canada, The Hebrew University of Jerusalem, Jerusalem, Israel.
Dahan S; Faculty of Medicine, Department of Biochemistry and Molecular Biology, The Institute for Medical Research Israel-Canada, The Hebrew University of Jerusalem, Jerusalem, Israel.
Cohen K; Faculty of Medicine, Department of Biochemistry and Molecular Biology, The Institute for Medical Research Israel-Canada, The Hebrew University of Jerusalem, Jerusalem, Israel.
Jaffe-Herman S; Faculty of Medicine, Department of Biochemistry and Molecular Biology, The Institute for Medical Research Israel-Canada, The Hebrew University of Jerusalem, Jerusalem, Israel.
Geminder O; Faculty of Medicine, Department of Biochemistry and Molecular Biology, The Institute for Medical Research Israel-Canada, The Hebrew University of Jerusalem, Jerusalem, Israel.
Baker M; Faculty of Medicine, Department of Biochemistry and Molecular Biology, The Institute for Medical Research Israel-Canada, The Hebrew University of Jerusalem, Jerusalem, Israel.
Nevo Y; Info-CORE, Bioinformatics Unit of the I-CORE Computation Center, The Hebrew University of Jerusalem, Jerusalem, Israel.
Plaschkes I; Info-CORE, Bioinformatics Unit of the I-CORE Computation Center, The Hebrew University of Jerusalem, Jerusalem, Israel.
Kay G; Faculty of Medicine, Department of Biochemistry and Molecular Biology, The Institute for Medical Research Israel-Canada, The Hebrew University of Jerusalem, Jerusalem, Israel.
Drier Y; Faculty of Medicine, The Lautenberg Center for Immunology and Cancer Research, The Institute for Medical Research Israel-Canada, The Hebrew University of Jerusalem, Jerusalem, Israel.
Berger M; Faculty of Medicine, The Lautenberg Center for Immunology and Cancer Research, The Institute for Medical Research Israel-Canada, The Hebrew University of Jerusalem, Jerusalem, Israel.
Salton M; Faculty of Medicine, Department of Biochemistry and Molecular Biology, The Institute for Medical Research Israel-Canada, The Hebrew University of Jerusalem, Jerusalem, Israel.; Pokaż więcej
Źródło:: PLoS biology [PLoS Biol] 2023 Jun 28; Vol. 21 (6), pp. e3002175. Date of Electronic Publication: 2023 Jun 28 (Print Publication: 2023).
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Basic Helix-Loop-Helix Transcription Factors*/genetics
Basic Helix-Loop-Helix Transcription Factors*/metabolism
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma*/metabolism
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma*/pathology
Animals ; Mice ; Chromatin ; Hematopoiesis/genetics ; Protein Isoforms/genetics ; Proto-Oncogene Proteins/genetics ; Proto-Oncogene Proteins/metabolism ; T-Cell Acute Lymphocytic Leukemia Protein 1/genetics ; Transcription Factors/metabolism

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Leukemia.