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Tytuł :
Epigenetic changes in human model KMT2A leukemias highlight early events during leukemogenesis.
Autorzy :
Milan T; Laboratory for High Throughput Biology, Institute for Research in Immunology and Cancer, Montréal, QC.
Celton M; Laboratory for High Throughput Biology, Institute for Research in Immunology and Cancer, Montréal, QC.
Lagacé K; Laboratory for High Throughput Biology, Institute for Research in Immunology and Cancer, Montréal, QC.
Roques É; Laboratory for High Throughput Biology, Institute for Research in Immunology and Cancer, Montréal, QC.
Safa-Tahar-Henni S; Laboratory for High Throughput Biology, Institute for Research in Immunology and Cancer, Montréal, QC.
Bresson E; Centre de recherche en infectiologie du CHUL, Centre de recherche du CHU de Québec - Université Laval, Québec City, QC, Canada; CHU de Québec - Université Laval - Hôpital Enfant-Jésus; Québec City, QC, Canada; Department of Medicine, Université Laval, Quebec City, QC.
Bergeron A; Centre de recherche en infectiologie du CHUL, Centre de recherche du CHU de Québec - Université Laval, Québec City, QC, Canada; CHU de Québec - Université Laval - Hôpital Enfant-Jésus; Québec City, QC, Canada; Department of Medicine, Université Laval, Quebec City, QC.
Hebert J; Division of Hematology-Oncology and Leukemia Cell Bank of Quebec, Maisonneuve-Rosemont Hospital, Montréal, QC, Canada; Department of Medicine, Université de Montréal, Montréal, QC.
Meshinchi S; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Cellot S; Department of pediatrics, division of Hematology, Ste-Justine Hospital, Montréal, QC.
Barabé F; Centre de recherche en infectiologie du CHUL, Centre de recherche du CHU de Québec - Université Laval, Québec City, QC, Canada; CHU de Québec - Université Laval - Hôpital Enfant-Jésus; Québec City, QC, Canada; Department of Medicine, Université Laval, Quebec City, QC.
Wilhelm BT; Laboratory for High Throughput Biology, Institute for Research in Immunology and Cancer, Montréal, QC, Canada; Department of Medicine, Université de Montréal, Montréal, QC. .
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Źródło :
Haematologica [Haematologica] 2022 Jan 01; Vol. 107 (1), pp. 86-99. Date of Electronic Publication: 2022 Jan 01.
Typ publikacji :
Journal Article
MeSH Terms :
Epigenesis, Genetic*
Leukemia, Myeloid*
Leukemia, Myeloid, Acute*/genetics
Adenylyl Cyclases ; Child ; DNA Methylation ; Histone-Lysine N-Methyltransferase ; Humans ; Jumonji Domain-Containing Histone Demethylases ; Mutation ; Myeloid-Lymphoid Leukemia Protein ; Translocation, Genetic
Czasopismo naukowe
Tytuł :
Inhibiting casein kinase 2 sensitizes acute lymphoblastic leukemia cells to venetoclax via MCL1 degradation.
Autorzy :
Lázaro-Navarro J; Department of Pediatric Oncology/Hematology, Charité-Universitätsmedizin Berlin, Berlin, Germany.; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Pimentel-Gutiérrez HJ; Department of Pediatric Oncology/Hematology, Charité-Universitätsmedizin Berlin, Berlin, Germany.; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Gauert A; Department of Pediatric Oncology/Hematology, Charité-Universitätsmedizin Berlin, Berlin, Germany.; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Hagemann AIH; Department of Pediatric Oncology/Hematology, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Eisenschmid J; Frankfurt Cancer Institute, Frankfurt, Germany.; Department of Medicine, Hematology/Oncology, Goethe University Hospital Frankfurt, Frankfurt, Germany.
Gökbuget N; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Medicine, Hematology/Oncology, Goethe University Hospital Frankfurt, Frankfurt, Germany.
Vick B; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Apoptosis in Hematopoietic Stem Cells, Helmholtz Center Munich, German Center for Environmental Health (HMGU), Munich, Germany.
Jeremias I; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Apoptosis in Hematopoietic Stem Cells, Helmholtz Center Munich, German Center for Environmental Health (HMGU), Munich, Germany.
Seyfried F; Department of Pediatrics and Adolescent Medicine, Ulm University Medical Center, Ulm, Germany; and.
Meyer LH; Department of Pediatrics and Adolescent Medicine, Ulm University Medical Center, Ulm, Germany; and.
Debatin KM; Department of Pediatrics and Adolescent Medicine, Ulm University Medical Center, Ulm, Germany; and.
Richer K; Medical Department II, Hematology/Oncology, University Medical Center Schleswig-Holstein, Campus Kiel, Germany.
Bultman M; Medical Department II, Hematology/Oncology, University Medical Center Schleswig-Holstein, Campus Kiel, Germany.
Neumann M; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.; Medical Department II, Hematology/Oncology, University Medical Center Schleswig-Holstein, Campus Kiel, Germany.
Hänzelmann S; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Serve H; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.; Frankfurt Cancer Institute, Frankfurt, Germany.; Department of Medicine, Hematology/Oncology, Goethe University Hospital Frankfurt, Frankfurt, Germany.
Astrahantseff K; Department of Pediatric Oncology/Hematology, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Rieger MA; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.; Frankfurt Cancer Institute, Frankfurt, Germany.; Department of Medicine, Hematology/Oncology, Goethe University Hospital Frankfurt, Frankfurt, Germany.
Eckert C; Department of Pediatric Oncology/Hematology, Charité-Universitätsmedizin Berlin, Berlin, Germany.; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Baldus CD; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.; Medical Department II, Hematology/Oncology, University Medical Center Schleswig-Holstein, Campus Kiel, Germany.
Bastian L; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.; Medical Department II, Hematology/Oncology, University Medical Center Schleswig-Holstein, Campus Kiel, Germany.
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Źródło :
Blood advances [Blood Adv] 2021 Dec 28; Vol. 5 (24), pp. 5501-5506.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Casein Kinase II*
Precursor Cell Lymphoblastic Leukemia-Lymphoma*/drug therapy
Bridged Bicyclo Compounds, Heterocyclic/pharmacology ; Humans ; Myeloid Cell Leukemia Sequence 1 Protein ; Sulfonamides
Czasopismo naukowe
Tytuł :
Transcription factor MEF2D is required for the maintenance of MLL-rearranged acute myeloid leukemia.
Autorzy :
Zhao L; Division of Hematology/Oncology, University of Alabama at Birmingham, Birmingham, AL.; O'Neal Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL.
Zhang P; Division of Hematology/Oncology, University of Alabama at Birmingham, Birmingham, AL.; O'Neal Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL.
Galbo PM; Department of Genetics, Albert Einstein College of Medicine, Bronx, NY.
Zhou X; Division of Hematology/Oncology, University of Alabama at Birmingham, Birmingham, AL.; O'Neal Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL.
Aryal S; Division of Hematology/Oncology, University of Alabama at Birmingham, Birmingham, AL.; O'Neal Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL.
Qiu S; Division of Hematology/Oncology, University of Alabama at Birmingham, Birmingham, AL.; O'Neal Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL.
Zhang H; Division of Hematology/Oncology, University of Alabama at Birmingham, Birmingham, AL.; O'Neal Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL.
Zhou Y; Department of Biomedical Engineering, School of Medicine and School of Engineering, University of Alabama at Birmingham, Birmingham, AL.
Li C; Department of Tumor Cell Biology & Cancer Biology Program/Comprehensive Cancer Center, St. Jude Children's Research Hospital, Memphis, TN.
Zheng D; Department of Genetics, Albert Einstein College of Medicine, Bronx, NY.; Department of Neurology, Albert Einstein College of Medicine, Bronx, NY; and.; Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY.
Bhatia R; Division of Hematology/Oncology, University of Alabama at Birmingham, Birmingham, AL.; O'Neal Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL.
Lu R; Division of Hematology/Oncology, University of Alabama at Birmingham, Birmingham, AL.; O'Neal Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL.
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Źródło :
Blood advances [Blood Adv] 2021 Nov 23; Vol. 5 (22), pp. 4727-4740.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Leukemia, Myeloid, Acute*/genetics
Transcription Factors*
Cell Differentiation ; Histone-Lysine N-Methyltransferase/genetics ; Humans ; MEF2 Transcription Factors/genetics ; Myeloid-Lymphoid Leukemia Protein/genetics
Czasopismo naukowe
Tytuł :
Neonatal acute lymphoblastic leukemia (MLL-AF9) with leukemia cutis.
Autorzy :
Yin YT; Department of Primary Care Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei, Taiwan.
Tseng JH; Department of Pharmacy, Taipei Medical University-Shuang Ho Hospital, New Taipei, Taiwan; College of Pharmacy, Taipei Medical University, Taipei, Taiwan.
Liu YL; Department of Pediatrics, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; Taipei Cancer Center, Taipei Medical University, Taipei, Taiwan; Department of Pediatrics, Taipei Medical University Hospital, Taipei, Taiwan.
Miser JS; Taipei Cancer Center, Taipei Medical University, Taipei, Taiwan; College of Medical Sciences and Technology, Taipei Medical University, Taipei, Taiwan; Department of Pediatrics, City of Hope National Medical Center, Duarte, CA, USA.
Chen SH; Department of Pediatrics, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; Taipei Cancer Center, Taipei Medical University, Taipei, Taiwan; Department of Pediatrics, Shuang Ho Hospital, Ministry of Health and Welfare, Taipei Medical University, New Taipei, Taiwan. Electronic address: .
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Źródło :
Pediatrics and neonatology [Pediatr Neonatol] 2021 Nov; Vol. 62 (6), pp. 676-678. Date of Electronic Publication: 2021 Jun 06.
Typ publikacji :
Letter
MeSH Terms :
Precursor Cell Lymphoblastic Leukemia-Lymphoma*/genetics
Acute Disease ; Humans ; Infant, Newborn ; Myeloid-Lymphoid Leukemia Protein/genetics ; Oncogene Proteins, Fusion
Opinia redakcyjna
Tytuł :
[Clinical characteristics and prognosis of MLL-AF6 positive patients with acute myeloid leukemia].
Autorzy :
Zhang MX; Department of Hematology, Peking University International Hospital, Beijing 102206, China.
Shi WZ; Heping Hospital Affiliated to Changzhi Medical College, Changzhi 046000, Shanxi, China.
Liu JX; Department of Hematology, Peking University International Hospital, Beijing 102206, China.
Wang CJ; Department of Hematology, Peking University International Hospital, Beijing 102206, China.
Li Y; Department of Hematology, Peking University International Hospital, Beijing 102206, China.
Wang W; Department of Hematology, Peking University International Hospital, Beijing 102206, China.
Jiang B; Department of Hematology, Peking University International Hospital, Beijing 102206, China.
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Źródło :
Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences [Beijing Da Xue Xue Bao Yi Xue Ban] 2021 Oct 18; Vol. 53 (5), pp. 915-920.
Typ publikacji :
Journal Article
MeSH Terms :
Hematopoietic Stem Cell Transplantation*
Leukemia, Myeloid, Acute*/diagnosis
Leukemia, Myeloid, Acute*/genetics
Adult ; Female ; Humans ; Male ; Myeloid-Lymphoid Leukemia Protein/genetics ; Oncogene Proteins, Fusion/genetics ; Prognosis ; Remission Induction ; Retrospective Studies
Czasopismo naukowe
Tytuł :
[A case of spontaneous remission of acute myeloid leukemia with MLL-AF9 rearrangement and abnormal liver function].
Autorzy :
Fan WJ; Department of Hematology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, China.
Xu TT; Department of Blood Transfusion, Henan Provincial People's Hospital, Zhengzhou 450000, China.
Sang LN; Department of Hematology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, China.
Guo JJ; Department of Hematology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, China.
Li YF; Department of Hematology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, China.
Pei ZX; Jiaozuo First People's Hospital, Jiaozuo 454002, China.
Jiang ZX; Department of Hematology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, China.
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Źródło :
Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi [Zhonghua Xue Ye Xue Za Zhi] 2021 Oct 14; Vol. 42 (10), pp. 851-857.
Typ publikacji :
Case Reports; Journal Article
MeSH Terms :
Leukemia, Myeloid, Acute*/genetics
Liver Diseases*
Adult ; Aged ; Aged, 80 and over ; Female ; Gene Rearrangement ; Humans ; Male ; Middle Aged ; Myeloid-Lymphoid Leukemia Protein/genetics ; Oncogene Proteins, Fusion/genetics ; Remission, Spontaneous ; Retrospective Studies
Czasopismo naukowe
Tytuł :
Hematopoietic stem cell transplantation for infants with high-risk KMT2A gene-rearranged acute lymphoblastic leukemia.
Autorzy :
Takachi T; Department of Hematology and Oncology, Shizuoka Children's Hospital, Shizuoka, Japan.
Watanabe T; Department of Health and Nutrition, Faculty of Psychological and Physical Science, Aichi Gakuin University, Nisshin, Japan.
Miyamura T; Department of Pediatrics, Graduate School of Medicine, Osaka University, Suita, Japan.
Moriya Saito A; Clinical Research Center, National Hospital Organization Nagoya Medical Center, Nagoya, Japan.
Deguchi T; Department of Pediatrics, Graduate School of Medicine, Mie University, Tsu, Japan.; Division of Cancer Immunodiagnostics, Children's Cancer Center, National Center for Child Health and Development, Tokyo, Japan.
Hori T; Department of Pediatrics, School of Medicine, Aichi Medical University, Nagakute, Japan.
Yamada T; Department of Pediatrics, School of Medicine, Aichi Medical University, Nagakute, Japan.; Department of Advanced Diagnosis, Clinical Research Center, National Hospital Organization Nagoya Medical Center, Nagoya, Japan.
Ohmori S; Department of Pharmacy, Shinshu University Hospital, Matsumoto, Japan.
Haba M; Department of Biopharmaceutics, Faculty of Pharmacy, Chiba Institute of Science, Choshi, Japan.
Aoki Y; Department of Pediatric Oncology, National Cancer Center Hospital, Tokyo, Japan.
Ishimaru S; Department of Pediatric Oncology, National Cancer Center Hospital, Tokyo, Japan.
Sasaki S; Department of Pediatrics, Graduate School of Medicine, Hirosaki University, Hirosaki, Japan.
Ohshima J; Department of Pediatrics, Hokkaido University, Sapporo, Japan.
Iguchi A; Department of Pediatrics, Hokkaido University, Sapporo, Japan.; Division of Hematology, Children's Cancer Center, National Center for Child Health and Development, Tokyo, Japan.
Takahashi Y; Department of Pediatrics, Graduate School of Medicine, Nagoya University, Nagoya, Japan.
Hyakuna N; Department of Pediatrics, University of the Ryukyus Hospital, Nishihara, Japan.
Manabe A; Department of Pediatrics, Hokkaido University, Sapporo, Japan.
Horibe K; Clinical Research Center, National Hospital Organization Nagoya Medical Center, Nagoya, Japan.
Ishii E; Department of Pediatrics, Graduate School of Medicine, Ehime University, Toon, Japan.
Koh K; Department of Hematology/Oncology, Saitama Children's Medical Center, Saitama, Japan; and.
Tomizawa D; Division of Leukemia and Lymphoma, Children's Cancer Center, National Center for Child Health and Development, Tokyo, Japan.
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Źródło :
Blood advances [Blood Adv] 2021 Oct 12; Vol. 5 (19), pp. 3891-3899.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Hematopoietic Stem Cell Transplantation*
Precursor Cell Lymphoblastic Leukemia-Lymphoma*/genetics
Precursor Cell Lymphoblastic Leukemia-Lymphoma*/therapy
Histone-Lysine N-Methyltransferase/genetics ; Humans ; Myeloid-Lymphoid Leukemia Protein/genetics ; Prognosis
Czasopismo naukowe
Tytuł :
Engineered type 1 regulatory T cells designed for clinical use kill primary pediatric acute myeloid leukemia cells.
Autorzy :
Cieniewicz B; Department of Pediatrics, Division of Stem Cell Biology and Regenerative Medicine, Stanford School of Medicine, Stanford.
Uyeda MJ; Department of Pediatrics, Division of Stem Cell Biology and Regenerative Medicine, Stanford School of Medicine, Stanford, CA; Stanford Institute for Stem Cell Biology and Regenerative Medicine, Stanford School of Medicine, Stanford.
Chen PP; Department of Pediatrics, Division of Stem Cell Biology and Regenerative Medicine, Stanford School of Medicine, Stanford.
Sayitoglu EC; Department of Pediatrics, Division of Stem Cell Biology and Regenerative Medicine, Stanford School of Medicine, Stanford.
Liu JM; Department of Pediatrics, Division of Stem Cell Biology and Regenerative Medicine, Stanford School of Medicine, Stanford.
Andolfi G; San Raffaele Telethon Institute for Gene Therapy, Milan.
Greenthal K; Department of Pediatrics, Division of Stem Cell Biology and Regenerative Medicine, Stanford School of Medicine, Stanford.
Bertaina A; Department of Pediatrics, Division of Stem Cell Biology and Regenerative Medicine, Stanford School of Medicine, Stanford.
Gregori S; San Raffaele Telethon Institute for Gene Therapy, Milan.
Bacchetta R; Department of Pediatrics, Division of Stem Cell Biology and Regenerative Medicine, Stanford School of Medicine, Stanford.
Lacayo NJ; Department of Pediatrics, Division of Stem Cell Biology and Regenerative Medicine, Stanford School of Medicine, Stanford.
Cepika AM; Department of Pediatrics, Division of Stem Cell Biology and Regenerative Medicine, Stanford School of Medicine, Stanford.
Roncarolo MG; Department of Pediatrics, Division of Stem Cell Biology and Regenerative Medicine, Stanford School of Medicine, Stanford, CA; Stanford Institute for Stem Cell Biology and Regenerative Medicine, Stanford School of Medicine, Stanford. .
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Źródło :
Haematologica [Haematologica] 2021 Oct 01; Vol. 106 (10), pp. 2588-2597. Date of Electronic Publication: 2021 Oct 01.
Typ publikacji :
Journal Article
MeSH Terms :
Leukemia, Myeloid, Acute*/genetics
Leukemia, Myeloid, Acute*/therapy
T-Lymphocytes, Regulatory*
Adult ; CD4-Positive T-Lymphocytes ; Child ; Graft vs Leukemia Effect ; Humans ; Translocation, Genetic
Czasopismo naukowe
Tytuł :
Comparing the effect of acupressure and ginger on chemotherapy gastrointestinal side-effects in children with leukemia.
Autorzy :
Essawy MA; Pediatric Nursing Department, Faculty of Nursing, Alexandria University, Egypt.
Abohadida RM; Pediatric Nursing Department, Faculty of Nursing, Alexandria University, Egypt.
Abd-Elkader WM; Pediatric Nursing Department, Faculty of Nursing, Alexandria University, Egypt.
Fathy HM; Pharmacognosy Departments, Faculty of Pharmacy, Alexandria University, Egypt. Electronic address: .
Hassab HM; Pediatrics Department, Faculty of Medicine, Alexandria University, Egypt.
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Źródło :
Complementary therapies in medicine [Complement Ther Med] 2021 Aug; Vol. 60, pp. 102730. Date of Electronic Publication: 2021 May 27.
Typ publikacji :
Journal Article
MeSH Terms :
Acupressure*
Antineoplastic Agents*/adverse effects
Ginger*
Leukemia*
Nausea*/chemically induced
Nausea*/therapy
Child ; Humans ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy
Czasopismo naukowe
Tytuł :
The molecular and serological investigation of Feline immunodeficiency virus and Feline leukemia virus in stray cats of Western Turkey.
Autorzy :
Muz D; Department of Virology, Tekirdag Namik Kemal University, Faculty of Veterinary Medicine, Tekirdag 59030, Turkey. Electronic address: .
Can H; Department of Molecular Biology, Ege University Faculty of Sciences, Bornova, Izmir, 35100, Turkey.
Karakavuk M; Department of Parasitology, Ege University Medical School, Bornova, Izmir, 35100, Turkey; Odemiş Training Collage, Ege University, Odemiş, İzmir, 35400, Turkey.
Döşkaya M; Department of Parasitology, Ege University Medical School, Bornova, Izmir, 35100, Turkey.
Özdemir HG; The Protection and Development Union of Izmir Bird Paradise, Izmir, Turkey.
Değirmenci Döşkaya A; Department of Parasitology, Ege University Medical School, Bornova, Izmir, 35100, Turkey.
Atalay Şahar E; Department of Molecular Biology, Ege University Faculty of Sciences, Bornova, Izmir, 35100, Turkey.
Pektaş B; Izmir Atatürk Training and Research Hospital, Department of Microbiology, Yeşilyurt, Izmir, Turkey.
Karakuş M; Department of Medical Microbiology, Hamidiye Faculty of Medicine, University of Health Sciences, İstanbul, Turkey.
Töz S; Department of Parasitology, Ege University Medical School, Bornova, Izmir, 35100, Turkey.
Özbel Y; Department of Parasitology, Ege University Medical School, Bornova, Izmir, 35100, Turkey.
Gürüz AY; Department of Parasitology, Ege University Medical School, Bornova, Izmir, 35100, Turkey.
Muz MN; Department of Parasitology, Tekirdag Namik Kemal University, Faculty of Veterinary Medicine, Tekirdag 59030, Turkey.
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Źródło :
Comparative immunology, microbiology and infectious diseases [Comp Immunol Microbiol Infect Dis] 2021 Oct; Vol. 78, pp. 101688. Date of Electronic Publication: 2021 Jun 29.
Typ publikacji :
Journal Article
MeSH Terms :
Cat Diseases*/epidemiology
Feline Acquired Immunodeficiency Syndrome*/epidemiology
Immunodeficiency Virus, Feline*/genetics
Leukemia, Feline*/epidemiology
Animals ; Cats ; Leukemia Virus, Feline/genetics ; Phylogeny ; Turkey/epidemiology
Czasopismo naukowe
Tytuł :
Targeting BRD4 in acute myeloid leukemia with partial tandem duplication of the MLL gene.
Autorzy :
Bill M; The Ohio State University, Comprehensive Cancer Center, Columbus, OH, USA; Medizinische Klinik und Poliklinik I, Universitätsklinikum Carl Gustav Carus Dresden, Dresden.
Goda C; The Ohio State University, Comprehensive Cancer Center, Columbus, OH.
Pepe F; The Ohio State University, Comprehensive Cancer Center, Columbus, OH.
Ozer HG; The Ohio State University, Department of Biomedical Informatics, Columbus, OH.
McNeil B; The Ohio State University, Comprehensive Cancer Center, Columbus, OH.
Zhang X; The Ohio State University, Department of Biomedical Informatics, Columbus, OH.
Karunasiri M; The Ohio State University, Comprehensive Cancer Center, Columbus, OH.
Kulkarni R; The Ohio State University, Comprehensive Cancer Center, Columbus, OH.
Kalyan S; The Ohio State University, Comprehensive Cancer Center, Columbus, OH.
Papaioannou D; The Ohio State University, Comprehensive Cancer Center, Columbus, OH, USA; Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH.
Ferenchak G; The Ohio State University, Comprehensive Cancer Center, Columbus, OH.
Garzon R; The Ohio State University, Comprehensive Cancer Center, Columbus, OH, USA; Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH.
Bradner JE; Dana-Faber Cancer Institute, Boston, MA.
Marcucci G; City of Hope Comprehensive Cancer Center, 1500 East Duarte Road, Duarte, CA 91010.
Caligiuri MA; City of Hope Comprehensive Cancer Center, 1500 East Duarte Road, Duarte, CA 91010.
Dorrance AM; The Ohio State University, Comprehensive Cancer Center, Columbus, OH, USA; Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH. .
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Źródło :
Haematologica [Haematologica] 2021 Sep 01; Vol. 106 (9), pp. 2527-2532. Date of Electronic Publication: 2021 Sep 01.
Typ publikacji :
Letter
MeSH Terms :
Leukemia, Myeloid, Acute*/genetics
Nuclear Proteins*/genetics
Cell Cycle Proteins ; Gene Duplication ; Humans ; Myeloid-Lymphoid Leukemia Protein/genetics ; Transcription Factors/genetics
Opinia redakcyjna
Tytuł :
[The Effect and Mechanism of Novel Telomerase Inhibitor Nilo 22 on Leukemia Cells].
Autorzy :
Yin JJ; State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Disease Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China.
Tang Q; High-throughput Molecular Drug Discovery Center, Tianjin International Joint Academy of Biomedicine, Tianjin 300457, China.
Gu JL; State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Disease Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China.
Li YF; State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Disease Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China.
Gao HE; State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Disease Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China,Department of Pharmacy, Tianjin First Central Hospital, School of Medicine, Nankai University, Tianjin 300192, China.
He M; State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Disease Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China.
Yang M; State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Disease Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China.
Zhang WS; State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Disease Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China.
Xu H; State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Disease Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China.
Wang CQ; State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Disease Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China.
Li YH; State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Disease Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China.
Bai CG; High-throughput Molecular Drug Discovery Center, Tianjin International Joint Academy of Biomedicine, Tianjin 300457, China,E-mail: .
Gao YD; State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Disease Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China,E-mail: .
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Źródło :
Zhongguo shi yan xue ye xue za zhi [Zhongguo Shi Yan Xue Ye Xue Za Zhi] 2021 Aug; Vol. 29 (4), pp. 1056-1064.
Typ publikacji :
Journal Article
MeSH Terms :
Leukemia*
Telomerase/*antagonists & inhibitors
Animals ; Apoptosis/drug effects ; Cell Cycle/drug effects ; Cell Line, Tumor ; Humans ; Mice ; Myeloid-Lymphoid Leukemia Protein/genetics ; Telomerase/metabolism ; Telomere/metabolism
Czasopismo naukowe
Tytuł :
Allogeneic Stem Cell Transplantation for Acute Myeloid Leukemia: Who, When, and How?
Autorzy :
Loke J; Centre for Clinical Haematology, Queen Elizabeth Hospital, Birmingham, United Kingdom.; CRUK Clinical Trials Unit, University of Birmingham, Birmingham, United Kingdom.
Buka R; Centre for Clinical Haematology, Queen Elizabeth Hospital, Birmingham, United Kingdom.; CRUK Clinical Trials Unit, University of Birmingham, Birmingham, United Kingdom.
Craddock C; Centre for Clinical Haematology, Queen Elizabeth Hospital, Birmingham, United Kingdom.; CRUK Clinical Trials Unit, University of Birmingham, Birmingham, United Kingdom.
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Źródło :
Frontiers in immunology [Front Immunol] 2021 May 03; Vol. 12, pp. 659595. Date of Electronic Publication: 2021 May 03 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Graft vs Leukemia Effect*
Hematopoietic Stem Cell Transplantation/*methods
Leukemia, Myeloid/*therapy
Transplantation Conditioning/*methods
Acute Disease ; Adult ; Disease-Free Survival ; Humans ; Leukemia, Myeloid/pathology ; Remission Induction ; Transplantation, Homologous
Czasopismo naukowe
Tytuł :
Identification of biomarkers for acute leukemia via machine learning-based stemness index.
Autorzy :
Zhang Y; Department of Biochemistry and Molecular Biology, Harbin Medical University, Harbin 150081, China.
Liu D; Department of Biochemistry and Molecular Biology, Harbin Medical University, Harbin 150081, China; Department of Hematology and Oncology, International Cancer Center, Shenzhen Key Laboratory, Shenzhen University General Hospital, Shenzhen University Clinical Medical Academy, Shenzhen University Health Science Center, Xueyuan AVE 1098, Shenzhen 518000, China.
Li F; Department of Biochemistry and Molecular Biology, Harbin Medical University, Harbin 150081, China.
Zhao Z; Department of Biochemistry and Molecular Biology, Harbin Medical University, Harbin 150081, China.
Liu X; The State Key Laboratory of Networking and Switching Technology, Beijing University of Posts and Telecommunications, Beijing 100876, China.
Gao D; School of Information and Communication Engineering, Beijing University of Posts and Telecommunications, Beijing 100876, China.
Zhang Y; Department of Biochemistry and Molecular Biology, Harbin Medical University, Harbin 150081, China.
Li H; Department of Biochemistry and Molecular Biology, Harbin Medical University, Harbin 150081, China. Electronic address: .
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Źródło :
Gene [Gene] 2021 Dec 15; Vol. 804, pp. 145903. Date of Electronic Publication: 2021 Aug 16.
Typ publikacji :
Journal Article
MeSH Terms :
Machine Learning*
Leukemia/*metabolism
Leukemia/*pathology
Neoplastic Stem Cells/*metabolism
Neoplastic Stem Cells/*pathology
Adaptor Proteins, Signal Transducing/genetics ; Adult ; Biomarkers, Tumor/genetics ; Databases, Genetic ; Female ; Gene Regulatory Networks ; Humans ; Leukemia/genetics ; Leukemia, Myeloid, Acute/genetics ; Leukemia, Myeloid, Acute/metabolism ; Leukemia, Myeloid, Acute/pathology ; Male ; Prognosis ; RNA, Messenger/genetics ; RNA-Binding Proteins/genetics ; Transcriptome
Czasopismo naukowe
Tytuł :
Fatal intracranial hemorrhage due to infantile acute lymphoblastic leukemia mimicking abusive head trauma.
Autorzy :
Unuma K; Department of Forensic Medicine, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Bunkyo-ku, Tokyo, Japan.
Makino Y; Department of Forensic Medicine, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.
Yamamoto K; Department of Comprehensive Pathology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Bunkyo-ku, Tokyo, Japan.
Hattori S; Department of Radiology, Chiba University Hospital, Chiba, Japan.
Arai N; Laboratory of Neuropathology, Tokyo Metropolitan Institute of Medical Science, Setagaya-ku, Tokyo, Japan.
Sakai K; Tokyo Medical Examiner's Office, Tokyo Metropolitan Government, Bunkyo-ku, Tokyo, Japan.
Kitagawa M; Department of Forensic Medicine, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.
Uemura K; Department of Forensic Medicine, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Bunkyo-ku, Tokyo, Japan.
Kanegane H; Department of Child Health and Development, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Bunkyo-ku, Tokyo, Japan.
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Źródło :
Journal of forensic sciences [J Forensic Sci] 2021 Nov; Vol. 66 (6), pp. 2504-2510. Date of Electronic Publication: 2021 Jul 23.
Typ publikacji :
Case Reports
MeSH Terms :
Intracranial Hemorrhages/*pathology
Precursor Cell Lymphoblastic Leukemia-Lymphoma/*diagnosis
Child Abuse/diagnosis ; Craniocerebral Trauma/diagnosis ; Diagnosis, Differential ; Female ; Gene Rearrangement ; Hematoma, Subdural/diagnostic imaging ; Hematoma, Subdural/pathology ; Histone-Lysine N-Methyltransferase/genetics ; Humans ; In Situ Hybridization, Fluorescence ; Infant ; Myeloid-Lymphoid Leukemia Protein/genetics ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/genetics ; Retinal Hemorrhage/diagnostic imaging ; Retinal Hemorrhage/pathology ; Tomography, X-Ray Computed
Raport
Tytuł :
Cytokine-like protein 1-induced survival of monocytes suggests a combined strategy targeting MCL1 and MAPK in CMML.
Autorzy :
Sevin M; INSERM U1287, Gustave Roussy Cancer Campus, Villejuif, France.
Debeurme F; INSERM U1287, Gustave Roussy Cancer Campus, Villejuif, France.
Laplane L; Centre National de la Recherche Scientifique (CNRS), Unité Mixte de Recherche (UMR) 8590, Université Paris I, Paris, France.
Badel S; INSERM U1287, Gustave Roussy Cancer Campus, Villejuif, France.
Morabito M; INSERM U1287, Gustave Roussy Cancer Campus, Villejuif, France.
Newman HL; Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL.
Torres-Martin M; Division of Liver Diseases, Icahn School of Medicine at Mount Sinai, New York, NY.
Yang Q; Human Genetics, University of Miami Miller School of Medicine, Miami, FL.
Badaoui B; Département d'Hématologie et Immunologie Biologiques, Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpitaux Universitaires Henri-Mondor, Créteil, France.
Wagner-Ballon O; Département d'Hématologie et Immunologie Biologiques, Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpitaux Universitaires Henri-Mondor, Créteil, France.; INSERM, Institut Mondor de Recherche Biomédicale, Equipe 9, Université Paris Est Créteil, Créteil, France.
Saada V; Department of Biopathology, Gustave Roussy Cancer Campus, Villejuif, France.
Sélimoglu-Buet D; INSERM U1287, Gustave Roussy Cancer Campus, Villejuif, France.
Kraus-Berthier L; Institut de Recherches Internationales Servier Oncology R&D Unit, Suresnes, France.
Banquet S; Institut de Recherches Internationales Servier Oncology R&D Unit, Suresnes, France.
Derreal A; Institut de Recherches Internationales Servier Oncology R&D Unit, Suresnes, France.
Fenaux P; Senior Hematology Department and.
Itzykson R; Department of Hematology, Hôpital Saint Louis, Université Paris Diderot, Paris, France.
Braun T; Department of Hematology, Hôpital Avicenne, Université Paris XIII, Bobigny, France.
Etienne G; Department of Medical Oncology, Institut Bergonie, Bordeaux, France.
Berthon C; Department of Hematology, Centre Hospitalier Universitaire Claude Huriez, Lille, France.; INSERM U1277-Canther, Institut pour la Recherche sur le Cancer de Lille, CNRS UMR 9020, Université de Lille, Lille, France.
Thépot S; Maladies du Sang, Centre Hospitalier Universitaire, Angers, France.
Kepp O; Metabolomics and Cell Biology Platforms, Institut Gustave Roussy, Villejuif, France.; INSERM U1138, Centre de Recherche des Cordeliers, Equipe Labellisée par la Ligue contre le Cancer, Université de Paris, Sorbonne Université, Institut Universitaire de France, Paris, France.
Kroemer G; Metabolomics and Cell Biology Platforms, Institut Gustave Roussy, Villejuif, France.; INSERM U1138, Centre de Recherche des Cordeliers, Equipe Labellisée par la Ligue contre le Cancer, Université de Paris, Sorbonne Université, Institut Universitaire de France, Paris, France.; Pôle de Biologie, AP-HP, Hôpital Européen Georges Pompidou, Paris, France.; Suzhou Institute for Systems Medicine, Chinese Academy of Medical Sciences, Suzhou, China.; Department of Women's and Children's Health, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden.
Padron E; Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL.
Figueroa ME; Human Genetics, University of Miami Miller School of Medicine, Miami, FL.; Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL.
Droin N; INSERM U1287, Gustave Roussy Cancer Campus, Villejuif, France.
Solary E; INSERM U1287, Gustave Roussy Cancer Campus, Villejuif, France.; Department of Hematology, Gustave Roussy Cancer Campus, Villejuif, France; and.; Faculté de Médecine, Université Paris-Saclay, Le Kremlin-Bicêtre, France.
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Źródło :
Blood [Blood] 2021 Jun 17; Vol. 137 (24), pp. 3390-3402.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Leukemia, Myelomonocytic, Chronic*/drug therapy
Leukemia, Myelomonocytic, Chronic*/metabolism
Leukemia, Myelomonocytic, Chronic*/pathology
Monocytes*/metabolism
Monocytes*/pathology
Blood Proteins/*metabolism
Cytokines/*metabolism
Extracellular Signal-Regulated MAP Kinases/*antagonists & inhibitors
MAP Kinase Signaling System/*drug effects
Myeloid Cell Leukemia Sequence 1 Protein/*antagonists & inhibitors
Protein Kinase Inhibitors/*pharmacology
Adult ; Aged ; Aged, 80 and over ; Cell Survival/drug effects ; Extracellular Signal-Regulated MAP Kinases/metabolism ; Female ; Humans ; Male ; Middle Aged ; Myeloid Cell Leukemia Sequence 1 Protein/metabolism ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Prognostic value of minimal residual disease measured by fusion-gene transcript in infants with KMT2A-rearranged acute lymphoblastic leukaemia treated according to the MLL-Baby protocol.
Autorzy :
Tsaur G; Regional Children's Hospital, Ekaterinburg, Russian Federation.; Research Institute of Medical Cell Technologies, Ekaterinburg, Russian Federation.; Ural State Medical University, Ekaterinburg, Russian Federation.
Popov A; National Research and Clinical Center for Pediatric Hematology, Oncology and Immunology, Moscow, Russian Federation.
Riger T; Regional Children's Hospital, Ekaterinburg, Russian Federation.; Research Institute of Medical Cell Technologies, Ekaterinburg, Russian Federation.
Kustanovich A; The Sharett Institute of Oncology, Hadassah Medical Center, Jerusalem, Israel.
Solodovnikov A; Research Institute of Medical Cell Technologies, Ekaterinburg, Russian Federation.; Ural State Medical University, Ekaterinburg, Russian Federation.
Shorikov E; PET-Technology Center of Nuclear Medicine, Ekaterinburg, Russian Federation.
Demina A; Regional Children's Hospital, Ekaterinburg, Russian Federation.; Research Institute of Medical Cell Technologies, Ekaterinburg, Russian Federation.
Verzhbitskaya T; Regional Children's Hospital, Ekaterinburg, Russian Federation.; Research Institute of Medical Cell Technologies, Ekaterinburg, Russian Federation.
Streneva O; Regional Children's Hospital, Ekaterinburg, Russian Federation.; Research Institute of Medical Cell Technologies, Ekaterinburg, Russian Federation.
Makarova O; Regional Children's Hospital, Ekaterinburg, Russian Federation.
Lapotentova E; Belarussian Research Center for Pediatric Oncology, Hematology and Immunology, Minsk, Belarus.
Aleinikova O; Belarussian Research Center for Pediatric Oncology, Hematology and Immunology, Minsk, Belarus.
Miakova N; National Research and Clinical Center for Pediatric Hematology, Oncology and Immunology, Moscow, Russian Federation.
Boichenko E; City Children's Hospital, 1, Saint-Petersburg, Russian Federation.
Kondratchik K; Morozov Children's Hospital, Moscow, Russian Federation.
Ponomareva N; Republican Children's Hospital, Moscow, Russian Federation.
Karachunskiy A; National Research and Clinical Center for Pediatric Hematology, Oncology and Immunology, Moscow, Russian Federation.
Roumiantsev A; National Research and Clinical Center for Pediatric Hematology, Oncology and Immunology, Moscow, Russian Federation.
Fechina L; Regional Children's Hospital, Ekaterinburg, Russian Federation.; Research Institute of Medical Cell Technologies, Ekaterinburg, Russian Federation.
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Źródło :
British journal of haematology [Br J Haematol] 2021 Jun; Vol. 193 (6), pp. 1151-1156. Date of Electronic Publication: 2021 Feb 14.
Typ publikacji :
Clinical Trial; Journal Article; Multicenter Study
MeSH Terms :
Histone-Lysine N-Methyltransferase*/blood
Histone-Lysine N-Methyltransferase*/genetics
Myeloid-Lymphoid Leukemia Protein*/blood
Myeloid-Lymphoid Leukemia Protein*/genetics
Oncogene Proteins, Fusion*/blood
Oncogene Proteins, Fusion*/genetics
Antineoplastic Combined Chemotherapy Protocols/*administration & dosage
Disease-Free Survival ; Female ; Humans ; Infant ; Infant, Newborn ; Male ; Neoplasm, Residual ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/blood ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/genetics ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/mortality ; Survival Rate
Czasopismo naukowe
Tytuł :
DYRK1a mediates BAFF-induced noncanonical NF-κB activation to promote autoimmunity and B-cell leukemogenesis.
Autorzy :
Li Y; Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX.
Xie X; Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX.
Jie Z; Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX.; State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Biology, School of Life Sciences, Xiamen University, Xiamen, China.
Zhu L; Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX.
Yang JY; Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX.; Department of Biological Sciences, Pusan National University, Busan, South Korea.
Ko CJ; Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX.
Gao T; Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX.
Jain A; Mass Spectrometry Proteomics Core.
Jung SY; Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX.
Baran N; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX; and.
Konopleva MY; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX; and.
Cheng X; Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX.
Sun SC; Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX.; MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX.
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Źródło :
Blood [Blood] 2021 Dec 09; Vol. 138 (23), pp. 2360-2371.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Autoimmunity*
B-Cell Activating Factor/*immunology
Leukemia, B-Cell/*immunology
NF-kappa B/*immunology
Protein Serine-Threonine Kinases/*immunology
Protein-Tyrosine Kinases/*immunology
Animals ; Autoimmune Diseases/immunology ; Autoimmune Diseases/pathology ; B-Lymphocytes/immunology ; B-Lymphocytes/pathology ; Carcinogenesis/immunology ; Carcinogenesis/pathology ; Cell Line, Tumor ; Humans ; Leukemia, B-Cell/pathology ; Mice ; Mice, Inbred C57BL ; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/immunology ; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/pathology
Czasopismo naukowe
Tytuł :
Convergence of oncogenic cooperation at single-cell and single-gene levels drives leukemic transformation.
Autorzy :
Liu Y; Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.; Department of Pediatrics, Harold C. Simmons Comprehensive Cancer Center, and Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
Gu Z; Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.; Department of Pediatrics, Harold C. Simmons Comprehensive Cancer Center, and Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
Cao H; Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.; Department of Pediatrics, Harold C. Simmons Comprehensive Cancer Center, and Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
Kaphle P; Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.; Department of Pediatrics, Harold C. Simmons Comprehensive Cancer Center, and Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
Lyu J; Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.; Department of Pediatrics, Harold C. Simmons Comprehensive Cancer Center, and Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
Zhang Y; Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.; Department of Pediatrics, Harold C. Simmons Comprehensive Cancer Center, and Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
Hu W; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
Chung SS; Division of Hematology Oncology, Department of Internal Medicine, and Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
Dickerson KE; Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.; Department of Pediatrics, Harold C. Simmons Comprehensive Cancer Center, and Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
Xu J; Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA. .; Department of Pediatrics, Harold C. Simmons Comprehensive Cancer Center, and Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Nov 03; Vol. 12 (1), pp. 6323. Date of Electronic Publication: 2021 Nov 03.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Single-Cell Analysis*
Carcinogenesis/*genetics
Carcinogenesis/*metabolism
Leukemia/*genetics
Leukemia/*metabolism
Animals ; Apoptosis ; Cell Cycle ; Enhancer of Zeste Homolog 2 Protein/deficiency ; Enhancer of Zeste Homolog 2 Protein/genetics ; Epigenomics ; GTP Phosphohydrolases ; Gene Expression Regulation, Neoplastic ; Genetic Heterogeneity ; Humans ; Leukemia, Myeloid, Acute ; Membrane Proteins ; Mice, Knockout ; Mutation ; Myeloid Cells ; Oncogenes ; Phenotype ; Transcriptome
Czasopismo naukowe

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