Temat: "leukemia inhibitory factor receptor" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: The LIFR Inhibitor EC359 Effectively Targets Type II Endometrial Cancer by Blocking LIF/LIFR Oncogenic Signaling.
Autorzy:: Spencer N; Division of Reproductive Research, Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, TX 78229, USA.
Rodriguez Sanchez AL; Division of Reproductive Research, Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, TX 78229, USA.
Gopalam R; Division of Reproductive Research, Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, TX 78229, USA.
Subbarayalu P; Department of Cell Systems & Anatomy, Greehey Children's Cancer Research Institute, University of Texas Health San Antonio, San Antonio, TX 78229, USA.
Medina DM; Department of Cell Systems & Anatomy, Greehey Children's Cancer Research Institute, University of Texas Health San Antonio, San Antonio, TX 78229, USA.
Yang X; Division of Reproductive Research, Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, TX 78229, USA.
Ramirez P; Division of Reproductive Research, Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, TX 78229, USA.
Randolph L; Division of Reproductive Research, Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, TX 78229, USA.
Aller EJ; Division of Reproductive Research, Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, TX 78229, USA.
Santhamma B; Evestra, Inc., San Antonio, TX 78245, USA.
Rao MK; Department of Cell Systems & Anatomy, Greehey Children's Cancer Research Institute, University of Texas Health San Antonio, San Antonio, TX 78229, USA.
Tekmal RR; Division of Reproductive Research, Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, TX 78229, USA.
Nair HB; Evestra, Inc., San Antonio, TX 78245, USA.
Kost ER; Division of Reproductive Research, Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, TX 78229, USA.
Vadlamudi RK; Division of Reproductive Research, Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, TX 78229, USA.; Mays Cancer Center, University of Texas Health San Antonio, San Antonio, TX 78229, USA.; Audie L. Murphy Division, South Texas Veterans Health Care System, San Antonio, TX 78229, USA.
Viswanadhapalli S; Division of Reproductive Research, Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, TX 78229, USA.; Mays Cancer Center, University of Texas Health San Antonio, San Antonio, TX 78229, USA.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2023 Dec 13; Vol. 24 (24). Date of Electronic Publication: 2023 Dec 13.
Typ publikacji:: Journal Article
MeSH Terms:: Signal Transduction*
Endometrial Neoplasms*/drug therapy
Humans ; Female ; Receptors, OSM-LIF/metabolism ; Leukemia Inhibitory Factor Receptor alpha Subunit/genetics ; Leukemia Inhibitory Factor Receptor alpha Subunit/metabolism

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Skocz do pozycji: 2.

Tytuł:: Whole exome sequencing identifies KIF26B, LIFR and LAMC1 mutations in familial vesicoureteral reflux.
Autorzy:: Bartik ZI; Department of Paediatric Surgery, Paediatric Uronephrologic Centre, Queen Silvia Children's Hospital, Göteborg, Sweden.; Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Sillén U; Department of Paediatric Surgery, Paediatric Uronephrologic Centre, Queen Silvia Children's Hospital, Göteborg, Sweden.; Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Djos A; Department of Laboratory Medicine, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Lindholm A; Department of Paediatrics, County Hospital Ryhov, Jönköping, Sweden.
Fransson S; Department of Laboratory Medicine, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2022 Nov 23; Vol. 17 (11), pp. e0277524. Date of Electronic Publication: 2022 Nov 23 (Print Publication: 2022).
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Kinesins*/genetics
Leukemia Inhibitory Factor Receptor alpha Subunit*/genetics
Vesico-Ureteral Reflux*/genetics
Laminin*/genetics
Humans ; Heterozygote ; Mutation ; Pedigree ; Exome Sequencing

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Skocz do pozycji: 3.

Tytuł:: An engineered ligand trap inhibits leukemia inhibitory factor as pancreatic cancer treatment strategy.
Autorzy:: Hunter SA; Cancer Biology Program, Stanford University School of Medicine, Stanford, CA, USA.
McIntosh BJ; Cancer Biology Program, Stanford University School of Medicine, Stanford, CA, USA.
Shi Y; Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA.
Sperberg RAP; Department of Bioengineering, Stanford University, Stanford, CA, USA.
Funatogawa C; Unchained Labs, Pleasanton, CA, USA.
Labanieh L; Department of Bioengineering, Stanford University, Stanford, CA, USA.
Soon E; Immunology Program, Stanford University School of Medicine, Stanford, CA, USA.
Wastyk HC; Department of Bioengineering, Stanford University, Stanford, CA, USA.
Mehta N; Department of Bioengineering, Stanford University, Stanford, CA, USA.
Carter C; Department of Bioengineering, Stanford University, Stanford, CA, USA.
Hunter T; Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA.
Cochran JR; Cancer Biology Program, Stanford University School of Medicine, Stanford, CA, USA. .; Department of Bioengineering, Stanford University, Stanford, CA, USA. .; Immunology Program, Stanford University School of Medicine, Stanford, CA, USA. .; Department of Chemical Engineering, Stanford University, Stanford, CA, USA. .; Pokaż więcej
Źródło:: Communications biology [Commun Biol] 2021 Apr 12; Vol. 4 (1), pp. 452. Date of Electronic Publication: 2021 Apr 12.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:: Leukemia Inhibitory Factor/*antagonists & inhibitors
Leukemia Inhibitory Factor Receptor alpha Subunit/*genetics
Pancreatic Neoplasms/*therapy
Humans ; Leukemia Inhibitory Factor Receptor alpha Subunit/metabolism ; Ligands ; Protein Engineering

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Skocz do pozycji: 4.

Tytuł:: Cytokimera GIL-11 rescued IL-6R deficient mice from partial hepatectomy-induced death by signaling via non-natural gp130:LIFR:IL-11R complexes.
Autorzy:: Rafii P; Institute of Biochemistry and Molecular Biology II, Medical Faculty, Heinrich-Heine-University, 40225, Düsseldorf, Germany.
Seibel C; Institute of Biochemistry and Molecular Biology II, Medical Faculty, Heinrich-Heine-University, 40225, Düsseldorf, Germany.
Weitz HT; Institute of Biochemistry and Molecular Biology II, Medical Faculty, Heinrich-Heine-University, 40225, Düsseldorf, Germany.
Ettich J; Institute of Biochemistry and Molecular Biology II, Medical Faculty, Heinrich-Heine-University, 40225, Düsseldorf, Germany.
Minafra AR; Institute of Biochemistry and Molecular Biology II, Medical Faculty, Heinrich-Heine-University, 40225, Düsseldorf, Germany.
Petzsch P; Biological and Medical Research Center (BMFZ), Medical Faculty, Heinrich-Heine-University, Universitätsstraße 1, 40225, Duesseldorf, Germany.
Lang A; Cardiovascular Research Laboratory, Medical Faculty, University Hospital Düsseldorf, 40225, Düsseldorf, Germany.
Floss DM; Institute of Biochemistry and Molecular Biology II, Medical Faculty, Heinrich-Heine-University, 40225, Düsseldorf, Germany.
Behnke K; Institute of Biochemistry and Molecular Biology II, Medical Faculty, Heinrich-Heine-University, 40225, Düsseldorf, Germany.
Köhrer K; Cardiovascular Research Laboratory, Medical Faculty, University Hospital Düsseldorf, 40225, Düsseldorf, Germany.
Moll JM; Institute of Biochemistry and Molecular Biology II, Medical Faculty, Heinrich-Heine-University, 40225, Düsseldorf, Germany.
Scheller J; Institute of Biochemistry and Molecular Biology II, Medical Faculty, Heinrich-Heine-University, 40225, Düsseldorf, Germany. .; Pokaż więcej
Źródło:: Communications biology [Commun Biol] 2023 Apr 15; Vol. 6 (1), pp. 418. Date of Electronic Publication: 2023 Apr 15.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Interleukin-11*/genetics
Hepatectomy*
Mice ; Animals ; Humans ; Cytokine Receptor gp130/genetics ; Cytokine Receptor gp130/metabolism ; Receptors, Interleukin-11 ; Antigens, CD/metabolism ; Interleukin-6/metabolism ; Signal Transduction ; Leukemia Inhibitory Factor Receptor alpha Subunit

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Skocz do pozycji: 5.

Tytuł:: Genome-wide screening for differentially methylated long noncoding RNAs identifies LIFR-AS1 as an epigenetically regulated lncRNA that inhibits the progression of colorectal cancer.
Autorzy:: Song P; Department of Gastrointestinal Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China.
Li Y; State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China.
Wang F; Department of Gastrointestinal Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China.
Pu L; Department of Gastrointestinal Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China.
Bao L; Department of Gastrointestinal Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China.
Gao H; Department of Gastrointestinal Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China.
Zhu C; Department of Oncology, Nanjing Second Hospital, Nanjing University of Chinese Medicine, Nanjing, China. .
Wang M; Department of Gastrointestinal Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China. .
Tao L; Department of Gastrointestinal Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China. .; Pokaż więcej
Źródło:: Clinical epigenetics [Clin Epigenetics] 2022 Oct 31; Vol. 14 (1), pp. 138. Date of Electronic Publication: 2022 Oct 31.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: RNA, Long Noncoding*/genetics
RNA, Long Noncoding*/metabolism
Colorectal Neoplasms*/pathology
MicroRNAs*/genetics
Humans ; Mice ; Animals ; Gene Expression Regulation, Neoplastic ; Cell Movement/genetics ; DNA Methylation ; Early Detection of Cancer ; Cell Proliferation/genetics ; Carcinogenesis/genetics ; Cell Line, Tumor ; Leukemia Inhibitory Factor Receptor alpha Subunit/genetics ; Leukemia Inhibitory Factor Receptor alpha Subunit/metabolism

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Skocz do pozycji: 6.

Tytuł:: Effects of leukemia inhibitory factor receptor on the adipogenic differentiation of human bone marrow mesenchymal stem cells.
Autorzy:: Wang T; Key Laboratory of System Bio‑Medicine of Jiangxi Province, Jiujiang University, Jiujiang, Jiangxi 332000, P.R. China.
Yan R; Clinical Skills Center, Affiliated Hospital of Jiujiang University, Jiujiang, Jiangxi 332000, P.R. China.
Xu X; Key Laboratory of System Bio‑Medicine of Jiangxi Province, Jiujiang University, Jiujiang, Jiangxi 332000, P.R. China.
Yu H; Key Laboratory of System Bio‑Medicine of Jiangxi Province, Jiujiang University, Jiujiang, Jiangxi 332000, P.R. China.
Wu J; Key Laboratory of System Bio‑Medicine of Jiangxi Province, Jiujiang University, Jiujiang, Jiangxi 332000, P.R. China.
Yang Y; Key Laboratory of System Bio‑Medicine of Jiangxi Province, Jiujiang University, Jiujiang, Jiangxi 332000, P.R. China.
Li W; Key Laboratory of System Bio‑Medicine of Jiangxi Province, Jiujiang University, Jiujiang, Jiangxi 332000, P.R. China.; Pokaż więcej
Źródło:: Molecular medicine reports [Mol Med Rep] 2019 Jun; Vol. 19 (6), pp. 4719-4726. Date of Electronic Publication: 2019 Apr 08.
Typ publikacji:: Journal Article
MeSH Terms:: Gene Expression Regulation*
Adipogenesis/*physiology
Cell Differentiation/*physiology
Leukemia Inhibitory Factor Receptor alpha Subunit/*metabolism
Mesenchymal Stem Cells/*physiology
Adipocytes/metabolism ; Adipocytes/pathology ; Adipogenesis/genetics ; Bone Marrow Cells ; CCAAT-Enhancer-Binding Protein-alpha/genetics ; CCAAT-Enhancer-Binding Protein-alpha/metabolism ; Cell Differentiation/genetics ; Fatty Acid-Binding Proteins/genetics ; Fatty Acid-Binding Proteins/metabolism ; Gene Expression Profiling ; Gene Knockdown Techniques ; Humans ; Leukemia Inhibitory Factor/genetics ; Leukemia Inhibitory Factor/metabolism ; Leukemia Inhibitory Factor Receptor alpha Subunit/genetics ; Mesenchymal Stem Cells/pathology ; PPAR gamma/genetics ; PPAR gamma/metabolism ; RNA, Messenger/metabolism

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Skocz do pozycji: 7.

Tytuł:: Leukemia Inhibitory Factor-Receptor is Dispensable for Prenatal Testis Development but is Required in Sertoli cells for Normal Spermatogenesis in Mice.
Autorzy:: Curley M; MRC Centre for Reproductive Health, University of Edinburgh, The Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh, EH16 4TJ, United Kingdom.
Milne L; MRC Centre for Reproductive Health, University of Edinburgh, The Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh, EH16 4TJ, United Kingdom.
Smith S; MRC Centre for Reproductive Health, University of Edinburgh, The Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh, EH16 4TJ, United Kingdom.
Atanassova N; Institute of Experimental Morphology, Pathology and Anthropology with Museum, Bulgarian Academy of Sciences, 1113, Sofia, Bulgaria.
Rebourcet D; MRC Centre for Reproductive Health, University of Edinburgh, The Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh, EH16 4TJ, United Kingdom.
Darbey A; MRC Centre for Reproductive Health, University of Edinburgh, The Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh, EH16 4TJ, United Kingdom.
Hadoke PWF; The British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, The Queen's Medical Research Institute, Edinburgh, EH16 4TJ, United Kingdom.
Wells S; Mary Lyons Centre, MRC Harwell, Harwell Campus, Oxfordshire, OX11 ORD, United Kingdom.
Smith LB; MRC Centre for Reproductive Health, University of Edinburgh, The Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh, EH16 4TJ, United Kingdom. .; School of Environmental and Life Sciences, University of Newcastle, Callaghan, NSW, 2308, Australia. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2018 Aug 01; Vol. 8 (1), pp. 11532. Date of Electronic Publication: 2018 Aug 01.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Spermatogenesis*
Leukemia Inhibitory Factor Receptor alpha Subunit/*metabolism
Sertoli Cells/*metabolism
Testis/*physiology
Animals ; Leukemia Inhibitory Factor Receptor alpha Subunit/deficiency ; Male ; Mice ; Mice, Knockout

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Skocz do pozycji: 8.

Tytuł:: The ILEI/LIFR complex induces EMT via the Akt and ERK pathways in renal interstitial fibrosis.
Autorzy:: Zhou J; Department of Pediatrics, First Hospital of China Medical University, Shenyang, 110001, China.
Jiang H; Department of Pediatrics, First Hospital of China Medical University, Shenyang, 110001, China.
Jiang H; Department of Pediatrics, First Hospital of China Medical University, Shenyang, 110001, China.
Fan Y; Department of Pediatrics, First Hospital of China Medical University, Shenyang, 110001, China.
Zhang J; Department of Pediatrics, First Hospital of China Medical University, Shenyang, 110001, China.
Ma X; Department of Pediatrics, First Hospital of China Medical University, Shenyang, 110001, China.
Yang X; Department of Pediatrics, First Hospital of China Medical University, Shenyang, 110001, China.
Sun Y; Department of Pediatrics, First Hospital of China Medical University, Shenyang, 110001, China.
Zhao X; Department of Pediatrics, First Hospital of China Medical University, Shenyang, 110001, China. zhaoxing_.; Pokaż więcej
Źródło:: Journal of translational medicine [J Transl Med] 2022 Jan 29; Vol. 20 (1), pp. 54. Date of Electronic Publication: 2022 Jan 29.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Kidney Diseases*/metabolism
Renal Insufficiency, Chronic*
Animals ; Child ; Disease Models, Animal ; Epithelial-Mesenchymal Transition ; Fibrosis ; Humans ; Leukemia Inhibitory Factor Receptor alpha Subunit/metabolism ; MAP Kinase Signaling System ; Male ; Mice ; Proto-Oncogene Proteins c-akt/metabolism ; Receptors, OSM-LIF/metabolism ; Transforming Growth Factor beta1/metabolism

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Skocz do pozycji: 9.

Tytuł:: Long Noncoding RNA LIFR-AS1: A New Player in Human Cancers.
Autorzy:: Bai Z; The First Affiliated Hospital of China Medical University, Department of Ultrasonic Diagnosis, No. 155 Nanjing North Street, Heping District, Shenyang, Liaoning 110001, China.
Wang X; The First Affiliated Hospital of China Medical University, Department of Ultrasonic Diagnosis, No. 155 Nanjing North Street, Heping District, Shenyang, Liaoning 110001, China.
Zhang Z; The First Affiliated Hospital of China Medical University, Department of Ultrasonic Diagnosis, No. 155 Nanjing North Street, Heping District, Shenyang, Liaoning 110001, China.; Pokaż więcej
Źródło:: BioMed research international [Biomed Res Int] 2022 Jan 13; Vol. 2022, pp. 1590815. Date of Electronic Publication: 2022 Jan 13 (Print Publication: 2022).
Typ publikacji:: Journal Article; Review
MeSH Terms:: Neoplasms*/genetics
RNA, Antisense*/genetics
RNA, Long Noncoding*/genetics
Cell Proliferation ; Gene Expression Regulation, Neoplastic ; Humans ; Leukemia Inhibitory Factor Receptor alpha Subunit/genetics ; Leukemia Inhibitory Factor Receptor alpha Subunit/metabolism

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Skocz do pozycji: 10.

Tytuł:: Low-dose aspirin can downregulate progesterone resistance and increase the expression of LIF in endometriosis during the implantation window.
Autorzy:: Wang L; Department of Obstetrics and Gynaecology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, People's Republic of China.
Zhang J; Department of Obstetrics and Gynaecology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, People's Republic of China.
Zhang H; Department of Obstetrics and Gynaecology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, People's Republic of China.
Li R; Department of Obstetrics and Gynaecology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, People's Republic of China.
Li C; Department of Obstetrics and Gynaecology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, People's Republic of China.
Zhao X; Department of Obstetrics and Gynaecology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, People's Republic of China.
Li M; Department of Obstetrics and Gynaecology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, People's Republic of China.; Pokaż więcej
Źródło:: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology [Gynecol Endocrinol] 2021 Aug; Vol. 37 (8), pp. 725-729. Date of Electronic Publication: 2021 May 11.
Typ publikacji:: Journal Article
MeSH Terms:: Aspirin/*administration & dosage
Embryo Implantation/*physiology
Endometriosis/*drug therapy
Leukemia Inhibitory Factor/*drug effects
Progesterone/*physiology
Receptors, Progesterone/*analysis
Animals ; Endometriosis/complications ; Endometriosis/metabolism ; Endometrium/chemistry ; Female ; Infertility, Female/drug therapy ; Infertility, Female/etiology ; Leukemia Inhibitory Factor/analysis ; Leukemia Inhibitory Factor/physiology ; Leukemia Inhibitory Factor Receptor alpha Subunit/analysis ; Leukemia Inhibitory Factor Receptor alpha Subunit/physiology ; Male ; Pregnancy ; Rats ; Rats, Sprague-Dawley ; Receptors, Progesterone/drug effects

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Skocz do pozycji: 11.

Tytuł:: LIFR inhibition enhances the therapeutic efficacy of HDAC inhibitors in triple negative breast cancer.
Autorzy:: Li M; Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, TX, 78229, USA.; Department of Respiratory Medicine, Xiangya Hospital, Central South University, Hunan, 410008, P.R. China.
Viswanadhapalli S; Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, TX, 78229, USA. .
Santhamma B; Evestra, Inc, San Antonio, TX, 78245, USA.
Pratap UP; Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, TX, 78229, USA.
Luo Y; Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, TX, 78229, USA.; Department of General Surgery, Xiangya Hospital, Central South University, Hunan, 410008, P.R. China.
Liu J; Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, TX, 78229, USA.; Department of Oncology, Xiangya Hospital, Central South University, Hunan, 410008, P.R. China.
Altwegg KA; Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, TX, 78229, USA.; Mays Cancer Center, University of Texas Health San Antonio, San Antonio, TX, 78229, USA.
Tang W; Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, TX, 78229, USA.; Department of Obstetrics and Gynecology, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, 210028, China.
Liu Z; Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, TX, 78229, USA.; Department of Oncology, Xiangya Hospital, Central South University, Hunan, 410008, P.R. China.
Li X; Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, TX, 78229, USA.
Ebrahimi B; Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, TX, 78229, USA.
Yan H; Department of Microbiology, Immunology and Molecular Genetics, University of Texas Health San Antonio, San Antonio, TX, 78229, USA.
Zou Y; Greehey Children's Cancer Research Institute, University of Texas Health San Antonio, San Antonio, TX, 78229, USA.
Konda S; Evestra, Inc, San Antonio, TX, 78245, USA.
Sareddy GR; Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, TX, 78229, USA.; Mays Cancer Center, University of Texas Health San Antonio, San Antonio, TX, 78229, USA.
Xu Z; Mays Cancer Center, University of Texas Health San Antonio, San Antonio, TX, 78229, USA.; Department of Microbiology, Immunology and Molecular Genetics, University of Texas Health San Antonio, San Antonio, TX, 78229, USA.
Chen Y; Mays Cancer Center, University of Texas Health San Antonio, San Antonio, TX, 78229, USA.; Greehey Children's Cancer Research Institute, University of Texas Health San Antonio, San Antonio, TX, 78229, USA.
Rao MK; Mays Cancer Center, University of Texas Health San Antonio, San Antonio, TX, 78229, USA.; Greehey Children's Cancer Research Institute, University of Texas Health San Antonio, San Antonio, TX, 78229, USA.
Brenner AJ; Mays Cancer Center, University of Texas Health San Antonio, San Antonio, TX, 78229, USA.; Department of Hematology & Oncology, University of Texas Health San Antonio, San Antonio, TX, 78229, USA.
Kaklamani VG; Mays Cancer Center, University of Texas Health San Antonio, San Antonio, TX, 78229, USA.
Tekmal RR; Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, TX, 78229, USA.; Mays Cancer Center, University of Texas Health San Antonio, San Antonio, TX, 78229, USA.
Ahmed G; Evestra, Inc, San Antonio, TX, 78245, USA.
Raj GV; Departments of Urology and Pharmacology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, 75390, USA.
Nickisch KJ; Evestra, Inc, San Antonio, TX, 78245, USA.
Nair HB; Evestra, Inc, San Antonio, TX, 78245, USA. .
Vadlamudi RK; Department of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, TX, 78229, USA. .; Mays Cancer Center, University of Texas Health San Antonio, San Antonio, TX, 78229, USA. .; Audie L. Murphy Division, South Texas Veterans Health Care System, San Antonio, TX, 78229, USA. .; Pokaż więcej
Źródło:: Communications biology [Commun Biol] 2021 Oct 29; Vol. 4 (1), pp. 1235. Date of Electronic Publication: 2021 Oct 29.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:: Antineoplastic Agents/*pharmacology
Histone Deacetylase Inhibitors/*pharmacology
Leukemia Inhibitory Factor Receptor alpha Subunit/*antagonists & inhibitors
Triple Negative Breast Neoplasms/*drug therapy
Animals ; Antineoplastic Agents/administration & dosage ; Apoptosis/drug effects ; Cell Survival/drug effects ; Female ; Histone Deacetylase Inhibitors/administration & dosage ; Mice ; Mice, SCID

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Skocz do pozycji: 12.

Tytuł:: Leukemia inhibitory factor promotes gastric cancer cell proliferation, migration, and invasion via the LIFR-Hippo-YAP pathway.
Autorzy:: Bian SB; Department of General Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing Key Laboratory of Cancer Invasion and Metastasis Research & National Clinical Research Center for Digestive Diseases, Beijing, China.; Department of General Surgery, Chinese People's Liberation Army General Hospital, Beijing, China.
Yang Y; Department of General Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing Key Laboratory of Cancer Invasion and Metastasis Research & National Clinical Research Center for Digestive Diseases, Beijing, China.
Liang WQ; Department of General Surgery, Chinese People's Liberation Army General Hospital, Beijing, China.
Zhang KC; Department of General Surgery, Chinese People's Liberation Army General Hospital, Beijing, China.
Chen L; Department of General Surgery, Chinese People's Liberation Army General Hospital, Beijing, China.
Zhang ZT; Department of General Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing Key Laboratory of Cancer Invasion and Metastasis Research & National Clinical Research Center for Digestive Diseases, Beijing, China.; Pokaż więcej
Źródło:: Annals of the New York Academy of Sciences [Ann N Y Acad Sci] 2021 Jan; Vol. 1484 (1), pp. 74-89. Date of Electronic Publication: 2020 Aug 22.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Cell Cycle Proteins/*genetics
Leukemia Inhibitory Factor/*genetics
Leukemia Inhibitory Factor Receptor alpha Subunit/*genetics
Stomach Neoplasms/*genetics
Transcription Factors/*genetics
Aged ; Apoptosis/genetics ; Biomarkers, Tumor/genetics ; Cell Cycle/genetics ; Cell Movement/genetics ; Cell Proliferation/genetics ; Female ; Gene Expression Regulation, Neoplastic/genetics ; Hippo Signaling Pathway ; Humans ; Male ; Middle Aged ; Neoplasm Invasiveness/genetics ; Neoplasm Invasiveness/pathology ; Protein Serine-Threonine Kinases/genetics ; RNA, Messenger/genetics ; Signal Transduction/genetics ; Stomach Neoplasms/pathology

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Skocz do pozycji: 13.

Tytuł:: A novel termination site in a case of Stüve–Wiedemann syndrome: case report and review of literature
Autorzy:: Deepali Bhalla
Sunil Sati
Donald Basel
Vijender Karody; Pokaż więcej
Temat:: Stüve–Wiedemann syndrome
JAK/STAT pathway
leukemia inhibitory factor receptor
skeletal dysplasia
Schwartz–Jampel syndrome Type 2
neonatal respiratory distress
Pediatrics
RJ1-570
Źródło:: Frontiers in Pediatrics, Vol 12 (2024)
Opis pliku:: electronic resource
Relacje:: https://www.frontiersin.org/articles/10.3389/fped.2024.1341841/full; https://doaj.org/toc/2296-2360
Dostęp URL:: https://doaj.org/article/9b453f71684e4f27b922669aabc1eb1d Link otwiera się w nowym oknie

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Szczegóły

Skocz do pozycji: 14.

Tytuł:: Oncostatin M reduces atherosclerosis development in APOE*3Leiden.CETP mice and is associated with increased survival probability in humans.
Autorzy:: Keulen DV; Laboratory of Experimental Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands.; Laboratory of Clinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht, The Netherlands.; Quorics B.V., Rotterdam, The Netherlands.; TNO-Metabolic Health Research, Gaubius Laboratory, Leiden, The Netherlands.
Pouwer MG; TNO-Metabolic Health Research, Gaubius Laboratory, Leiden, The Netherlands.; Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.
Emilsson V; Icelandic Heart Association, Kopavogur, Iceland.; Faculty of Pharmaceutical Sciences, University of Iceland, Reykjavik, Iceland.
Matic LP; Department of Molecular Medicine and Surgery, Karolinska Institutet, Solna, Sweden.
Pieterman EJ; TNO-Metabolic Health Research, Gaubius Laboratory, Leiden, The Netherlands.
Hedin U; Department of Molecular Medicine and Surgery, Karolinska Institutet, Solna, Sweden.
Gudnason V; Icelandic Heart Association, Kopavogur, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
Jennings LL; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, United States.
Holmstrøm K; Bioneer A/S, Hørsholm, Denmark.
Nielsen BS; Bioneer A/S, Hørsholm, Denmark.
Pasterkamp G; Laboratory of Clinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht, The Netherlands.
Lindeman JHN; Department of Vascular Surgery, Leiden University Medical Center, Leiden, The Netherlands.
van Gool AJ; TNO- Microbiology & Systems Biology, Zeist, The Netherlands.
Sollewijn Gelpke MD; Molecular Profiling Consulting, London, United Kingdom.
Princen HMG; TNO-Metabolic Health Research, Gaubius Laboratory, Leiden, The Netherlands.
Tempel D; Laboratory of Experimental Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands.; Laboratory of Clinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht, The Netherlands.; Quorics B.V., Rotterdam, The Netherlands.; SkylineDx B.V., Rotterdam, The Netherlands.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2019 Aug 28; Vol. 14 (8), pp. e0221477. Date of Electronic Publication: 2019 Aug 28 (Print Publication: 2019).
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
MeSH Terms:: Apolipoproteins E/*metabolism
Atherosclerosis/*pathology
Cholesterol Ester Transfer Proteins/*metabolism
Oncostatin M/*metabolism
Animals ; Atherosclerosis/blood ; Atherosclerosis/genetics ; Biomarkers/metabolism ; Coronary Disease/blood ; Coronary Disease/genetics ; Coronary Disease/mortality ; Endothelial Cells/metabolism ; Endothelial Cells/pathology ; Female ; Humans ; Inflammation/pathology ; Interleukin-6/metabolism ; Leukemia Inhibitory Factor Receptor alpha Subunit/genetics ; Leukemia Inhibitory Factor Receptor alpha Subunit/metabolism ; Mice, Transgenic ; Monocytes/pathology ; Oncostatin M/blood ; Oncostatin M/genetics ; Oncostatin M Receptor beta Subunit/genetics ; Oncostatin M Receptor beta Subunit/metabolism ; Phenotype ; Plaque, Atherosclerotic/genetics ; Plaque, Atherosclerotic/pathology ; Probability ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Survival Analysis ; Vascular Cell Adhesion Molecule-1/metabolism

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Skocz do pozycji: 15.

Tytuł:: Knockdown of Musashi RNA Binding Proteins Decreases Radioresistance but Enhances Cell Motility and Invasion in Triple-Negative Breast Cancer.
Autorzy:: Troschel FM; Department of Radiation Oncology, University Hospital Münster, 48149 Münster, Germany.
Minte A; Department of Radiation Oncology, University Hospital Münster, 48149 Münster, Germany.; Department of Gynecology and Obstetrics, University Hospital Münster, 48149 Münster, Germany.
Ismail YM; Medical Oncology Department, National Cancer Institute, Cairo University, 11796 Cairo, Egypt.
Kamal A; Surgical Oncology Department, National Cancer Institute, Cairo University, 11796 Cairo, Egypt.
Abdullah MS; Biotechnology/Biomolecular Chemistry program, Chemistry Department, Faculty of Science, Cairo University, 12613 Giza, Egypt.
Ahmed SH; Biotechnology/Biomolecular Chemistry program, Chemistry Department, Faculty of Science, Cairo University, 12613 Giza, Egypt.
Deffner M; Department of Radiation Oncology, University Hospital Münster, 48149 Münster, Germany.
Kemper B; Biomedical Technology Center, Medical Faculty, University of Münster, 48149 Münster, Germany.
Kiesel L; Department of Gynecology and Obstetrics, University Hospital Münster, 48149 Münster, Germany.
Eich HT; Department of Radiation Oncology, University Hospital Münster, 48149 Münster, Germany.
Ibrahim SA; Zoology Department, Faculty of Science, Cairo University, 12613 Giza, Egypt.
Götte M; Department of Gynecology and Obstetrics, University Hospital Münster, 48149 Münster, Germany.
Greve B; Department of Radiation Oncology, University Hospital Münster, 48149 Münster, Germany.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2020 Mar 21; Vol. 21 (6). Date of Electronic Publication: 2020 Mar 21.
Typ publikacji:: Journal Article
MeSH Terms:: Leukemia Inhibitory Factor Receptor alpha Subunit/*metabolism
Neoplastic Stem Cells/*metabolism
Nerve Tissue Proteins/*metabolism
RNA-Binding Proteins/*metabolism
Receptor, Notch1/*metabolism
Receptor, Notch2/*metabolism
Triple Negative Breast Neoplasms/*metabolism
Adult ; Apoptosis/genetics ; Apoptosis/radiation effects ; Cell Cycle/genetics ; Cell Cycle/radiation effects ; Cell Line, Tumor ; Cell Movement/genetics ; Cell Movement/radiation effects ; Cell Proliferation/genetics ; Cell Proliferation/radiation effects ; Down-Regulation ; ErbB Receptors/genetics ; ErbB Receptors/metabolism ; Female ; Gene Expression Regulation, Neoplastic/genetics ; Gene Expression Regulation, Neoplastic/radiation effects ; Gene Knockdown Techniques ; Gene Silencing ; Humans ; Hyaluronan Receptors ; Middle Aged ; Neoplastic Stem Cells/radiation effects ; Nerve Tissue Proteins/genetics ; RNA, Small Interfering/genetics ; RNA, Small Interfering/metabolism ; RNA-Binding Proteins/genetics ; Receptor, Notch1/genetics ; Receptor, Notch2/genetics ; Triple Negative Breast Neoplasms/genetics

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Skocz do pozycji: 16.

Tytuł:: Target prediction and validation of microRNAs expressed from FSHR and aromatase genes in human ovarian granulosa cells.
Autorzy:: Rooda I; Department of Chemistry and Biotechnology, Tallinn University of Technology, Tallinn, Estonia.; Competence Centre on Health Technologies, Tartu, Estonia.
Hensen K; Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia.
Kaselt B; Department of Chemistry and Biotechnology, Tallinn University of Technology, Tallinn, Estonia.
Kasvandik S; Proteomics Core Facility, Institute of Technology, University of Tartu, Tartu, Estonia.
Pook M; Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia.
Kurg A; Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia.
Salumets A; Competence Centre on Health Technologies, Tartu, Estonia.; Institute of Clinical Medicine, Department of Obstetrics and Gynecology, University of Tartu, Tartu, Estonia.; Institute of Biomedicine and Translational Medicine, Department of Biomedicine, University of Tartu, Tartu, Estonia.; Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Velthut-Meikas A; Department of Chemistry and Biotechnology, Tallinn University of Technology, Tallinn, Estonia. .; Competence Centre on Health Technologies, Tartu, Estonia. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2020 Feb 10; Vol. 10 (1), pp. 2300. Date of Electronic Publication: 2020 Feb 10.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Gene Expression Regulation, Developmental*
Cumulus Cells/*physiology
MicroRNAs/*metabolism
Ovarian Follicle/*growth & development
Adult ; Aromatase/genetics ; Cell Line, Tumor ; Female ; Follicle Stimulating Hormone/metabolism ; Gene Expression Profiling ; Humans ; Leukemia Inhibitory Factor Receptor alpha Subunit/genetics ; MicroRNAs/genetics ; Oligonucleotide Array Sequence Analysis ; Ovarian Follicle/cytology ; PTEN Phosphohydrolase/genetics ; Primary Cell Culture ; Receptors, FSH/genetics ; Young Adult

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Skocz do pozycji: 17.

Tytuł:: Leukemia inhibitory factor promotes the regeneration of rat uterine horns with full-thickness injury.
Autorzy:: Xue B; Department of Obstetrics and Gynecology, Drum Tower Clinical Medical College of Nanjing Medical University, 321 Zhongshan Rd., Nanjing, 210008, China.
Liu D; Department of Obstetrics and Gynecology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, 321 Zhongshan Rd., Nanjing, 210008, China.
Song M; Department of Obstetrics and Gynecology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, 321 Zhongshan Rd., Nanjing, 210008, China.
Zhao G; Department of Obstetrics and Gynecology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, 321 Zhongshan Rd., Nanjing, 210008, China.
Cao Y; Department of Obstetrics and Gynecology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, 321 Zhongshan Rd., Nanjing, 210008, China.
Yan G; Department of Obstetrics and Gynecology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, 321 Zhongshan Rd., Nanjing, 210008, China.
Dai J; Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, 3 Nanyitiao, Zhongguancun, Beijing, 100190, China.
Hu Y; Department of Obstetrics and Gynecology, Drum Tower Clinical Medical College of Nanjing Medical University, 321 Zhongshan Rd., Nanjing, 210008, China.; Department of Obstetrics and Gynecology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, 321 Zhongshan Rd., Nanjing, 210008, China.; Pokaż więcej
Źródło:: Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society [Wound Repair Regen] 2019 Sep; Vol. 27 (5), pp. 477-487. Date of Electronic Publication: 2019 Jun 03.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Leukemia Inhibitory Factor/*pharmacology
Neovascularization, Physiologic/*drug effects
Regeneration/*physiology
Signal Transduction/*physiology
Uterus/*pathology
Wound Healing/*physiology
Animals ; Cell Proliferation ; Disease Models, Animal ; Female ; Gene Expression Regulation ; Leukemia Inhibitory Factor Receptor alpha Subunit/antagonists & inhibitors ; Rats ; Rats, Sprague-Dawley ; Regeneration/drug effects ; Tissue Scaffolds ; Uterus/immunology ; Uterus/injuries