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Tytuł :
Cell Type-Dependent Escape of Capsid Inhibitors by Simian Immunodeficiency Virus SIVcpz.
Autorzy :
Twizerimana AP; Clinic for Gastroenterology, Hepatology, and Infectiology, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Scheck R; Clinic for Gastroenterology, Hepatology, and Infectiology, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Becker D; Institute for Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Zhang Z; Clinic for Gastroenterology, Hepatology, and Infectiology, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Wammers M; Clinic for Gastroenterology, Hepatology, and Infectiology, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Avelar L; Institute for Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Pflieger M; Institute for Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Häussinger D; Clinic for Gastroenterology, Hepatology, and Infectiology, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Kurz T; Institute for Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Gohlke H; Institute for Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.; John von Neumann Institute for Computing, Forschungszentrum Jülich GmbH, Jülich, Germany.; Jülich Supercomputing Centre, Forschungszentrum Jülich GmbH, Jülich, Germany.; Institute of Biological Information Processing (IBI-7: Structural Biochemistry), Forschungszentrum Jülich GmbH, Jülich, Germany.
Münk C; Clinic for Gastroenterology, Hepatology, and Infectiology, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany .
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Źródło :
Journal of virology [J Virol] 2020 Nov 09; Vol. 94 (23). Date of Electronic Publication: 2020 Nov 09 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Anti-HIV Agents/*pharmacology
Capsid/*drug effects
Capsid Proteins/*chemistry
Capsid Proteins/*drug effects
Capsid Proteins/*metabolism
Simian Immunodeficiency Virus/*drug effects
mRNA Cleavage and Polyadenylation Factors/*chemistry
mRNA Cleavage and Polyadenylation Factors/*metabolism
Animals ; Binding Sites ; Capsid Proteins/genetics ; Cell Line ; Cyclophilin A/genetics ; Cyclophilin A/metabolism ; Gene Knockout Techniques ; HEK293 Cells ; HIV-1 ; HeLa Cells ; Humans ; Indazoles/pharmacology ; Indoles/pharmacology ; Leukocytes, Mononuclear/virology ; Macrophages/virology ; Models, Molecular ; Pan troglodytes/virology ; Phenylalanine/analogs & derivatives ; Phenylalanine/pharmacology ; Protein Conformation ; Protein Interaction Domains and Motifs ; Pyridines/pharmacology ; Sequence Alignment ; Simian Acquired Immunodeficiency Syndrome/virology ; Simian Immunodeficiency Virus/chemistry ; Simian Immunodeficiency Virus/genetics ; Zoonoses ; mRNA Cleavage and Polyadenylation Factors/genetics
Czasopismo naukowe
Tytuł :
Epidemiology, clinical picture and long-term outcomes of FIP1L1-PDGFRA-positive myeloid neoplasm with eosinophilia: Data from 151 patients.
Autorzy :
Rohmer J; National Reference Center for Hypereosinophilic syndromes (CEREO), Suresnes, France.; Department of Internal Medicine, Hôpital Foch, Suresnes, France.
Couteau-Chardon A; National Reference Center for Hypereosinophilic syndromes (CEREO), Suresnes, France.; Department of Intensive Care medicine, Centre Hospitalier Annecy Genevois, Saint-Julien-en-Genevois, France.
Trichereau J; National Reference Center for Hypereosinophilic syndromes (CEREO), Suresnes, France.; Clinical Research Department, Hôpital Foch, Suresnes, France.
Panel K; National Reference Center for Hypereosinophilic syndromes (CEREO), Suresnes, France.; Clinical Research Department, Hôpital Foch, Suresnes, France.
Gesquiere C; National Reference Center for Hypereosinophilic syndromes (CEREO), Suresnes, France.
Ben Abdelali R; Pole Hématologie et Oncologie, Laboratoire CERBA, Saint-Ouen-l'Aumône, France.
Bidet A; Laboratory of Hematology, CHU de Bordeaux, Pessac, France.
Bladé JS; Department of Oncology, Sainte-Anne Military Teaching Hospital, Toulon, France.
Cayuela JM; Laboratory of Hematology, Saint-Louis Hospital, University of Paris, Paris, France.
Cony-Makhoul P; National Reference Center for Hypereosinophilic syndromes (CEREO), Suresnes, France.; Hematology Department, CH Annecy Genevois, Annecy, France.
Cottin V; National Coordinating Reference Center for Rare Pulmonary Diseases, Louis Pradel Hospital, Lyon, France.; Hospices Civils de Lyon, UMR754, University Claude Bernard Lyon 1, Lyon, France.
Delabesse E; Laboratory of Hematology, Institut Universitaire du Cancer de Toulouse Oncopole, CHU de Toulouse, Toulouse, France.
Ebbo M; National Reference Center for Hypereosinophilic syndromes (CEREO), Suresnes, France.; Aix Marseille University, Department of Internal Medicine, Hôpital de la Timone, AP-HM, CNRS, INSERM, CIML, Marseille, France.
Fain O; Department of Internal Medicine, CHU Saint Antoine, Paris, France.
Flandrin P; Laboratory of Hematology, Hôpital Nord, CHU de Saint-Étienne, Saint-Étienne, France.
Galicier L; Department of Clinical Immunology, Saint Louis hospital, Paris, France.
Godon C; Laboratoire de cytogénétique hématologique, CHU de Nantes, Nantes, France.
Grardel N; Laboratory of Hematology, CHU de Lille, Lille, France.
Guffroy A; National Reference Center for Hypereosinophilic syndromes (CEREO), Suresnes, France.; Department of Clinical Immunology and Internal Medicine, National Reference Center for Systemic Autoimmune Diseases (RESO), Tertiary Center for Primary Immunodeficiency, Strasbourg University Hospital, Strasbourg, France.
Hamidou M; National Reference Center for Hypereosinophilic syndromes (CEREO), Suresnes, France.; Department of Internal Medicine, CHU de Nantes, Nantes, France.
Hunault M; CRCINA CHU d'Angers, Angers, France.
Lengline E; Department of Hematology, Saint Louis hospital, Paris, France.
Lhomme F; Department of Hematology, CHU Pontchaillou, Rennes, France.
Lhermitte L; University of Paris, Institut National de Recherche Médicale U1151, Laboratory of Onco-Hematology, Hôpital Necker Enfants-Malades, Paris, France.
Machelart I; National Reference Center for Hypereosinophilic syndromes (CEREO), Suresnes, France.; Department of Internal Medicine, CHU de Bordeaux, Bordeaux, France.
Mauvieux L; Université de Strasbourg, INSERM U1113 Interface de Recherche Fondamentale et Appliquée en Cancérologie, Laboratoire d'hématologie du CHRU Strasbourg, Faculté de Médecine de Strasbourg, Strasbourg, France.
Mohr C; Service d'Hématologie Oncologie, CHU, Groupe Hospitalier Sud Réunion, Saint Pierre, Reunion, France.
Mozicconacci MJ; Institut Paoli-Calmettes, Centre de Recherche en Cancérologie de Marseille, Biopathologie, Marseille, France.
Naguib D; Laboratory of Hematology, CHU Caen, Caen, France.
Nicolini FE; Department of Hematology, INSERM U 1052, CRCL, Centre Léon Bérard, Lyon, France.
Rey J; Department of Hematology, Institut Paoli-Calmettes, Marseille, France.
Rousselot P; Hematology Department, Versailles André Mignot Hospital, University Paris-Saclay, Le Chesnay, France.
Tavitian S; Service d'Hématologie, Institut Universitaire du Cancer de Toulouse-Oncopole, Centre Hospitalier Universitaire de Toulouse, Toulouse, France.
Terriou L; National Reference Center for Hypereosinophilic syndromes (CEREO), Suresnes, France.; Université de Lille, CHU Lille, Département de Médecine Interne et Immunologie Clinique, Centre de Référence des Maladies Auto-immunes Systémiques Rares du Nord et Nord-Ouest de France (CeRAINO), Lille, France.
Lefèvre G; National Reference Center for Hypereosinophilic syndromes (CEREO), Suresnes, France.; Université de Lille, CHU Lille, Département de Médecine Interne et Immunologie Clinique, Centre de Référence des Maladies Auto-immunes Systémiques Rares du Nord et Nord-Ouest de France (CeRAINO), Lille, France.
Preudhomme C; Laboratory of Hematology, CHU de Lille, Lille, France.
Kahn JE; National Reference Center for Hypereosinophilic syndromes (CEREO), Suresnes, France.; Université Paris-Saclay, Department of Internal Medicine, Ambroise Paré hospital, Boulogne Billancourt Cedex, France.
Groh M; National Reference Center for Hypereosinophilic syndromes (CEREO), Suresnes, France.; Department of Internal Medicine, Hôpital Foch, Suresnes, France.
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Corporate Authors :
CEREO and GBMHM collaborators
Źródło :
American journal of hematology [Am J Hematol] 2020 Nov; Vol. 95 (11), pp. 1314-1323. Date of Electronic Publication: 2020 Sep 19.
Typ publikacji :
Clinical Trial; Journal Article; Multicenter Study
MeSH Terms :
Eosinophilia*/blood
Eosinophilia*/drug therapy
Eosinophilia*/genetics
Eosinophilia*/mortality
Hematologic Neoplasms*/blood
Hematologic Neoplasms*/drug therapy
Hematologic Neoplasms*/genetics
Hematologic Neoplasms*/mortality
Myeloproliferative Disorders*/blood
Myeloproliferative Disorders*/drug therapy
Myeloproliferative Disorders*/genetics
Myeloproliferative Disorders*/mortality
Oncogene Proteins, Fusion*/blood
Oncogene Proteins, Fusion*/genetics
Receptor, Platelet-Derived Growth Factor alpha*/blood
Receptor, Platelet-Derived Growth Factor alpha*/genetics
mRNA Cleavage and Polyadenylation Factors*/blood
mRNA Cleavage and Polyadenylation Factors*/genetics
Adrenal Cortex Hormones/*administration & dosage
Adult ; Disease-Free Survival ; Female ; France/epidemiology ; Humans ; Incidence ; Male ; Middle Aged ; Retrospective Studies ; Survival Rate ; Tryptases/blood ; Vitamin B 12/blood
Czasopismo naukowe
Tytuł :
Recessive, Deleterious Variants in SMG8 Expand the Role of Nonsense-Mediated Decay in Developmental Disorders in Humans.
Autorzy :
Alzahrani F; Deparment of Genetics, King Faisal Specialist Hospital and Research Center, Riyadh 11211, Saudi Arabia.
Kuwahara H; Computational Bioscience Research Center, Computer, Electrical, and Mathematical Sciences and Engineering Division, King Abdullah University of Science and Technology, Thuwal 23955, Saudi Arabia.
Long Y; Computational Bioscience Research Center, Computer, Electrical, and Mathematical Sciences and Engineering Division, King Abdullah University of Science and Technology, Thuwal 23955, Saudi Arabia.
Al-Owain M; Department of Medical Genetics, King Faisal Specialist Hospital and Research Center, Riyadh 11211, Saudi Arabia.
Tohary M; Department of Medical Genetics, King Faisal Specialist Hospital and Research Center, Riyadh 11211, Saudi Arabia.
AlSayed M; Department of Medical Genetics, King Faisal Specialist Hospital and Research Center, Riyadh 11211, Saudi Arabia.
Mahnashi M; Division of Genetics, Department of Pediatrics, King Fahad Central Hospital, Jazan 82666, Saudi Arabia.
Fathi L; Division of Genetics, Department of Pediatrics, King Fahad Central Hospital, Jazan 82666, Saudi Arabia.
Alnemer M; Department of Obstetrics and Gynecology, King Faisal Specialist Hospital and Research Center, Riyadh 11211, Saudi Arabia.
Al-Hamed MH; Deparment of Genetics, King Faisal Specialist Hospital and Research Center, Riyadh 11211, Saudi Arabia.
Lemire G; Department of Genetics, Children's Hospital of Eastern Ontario, Ottawa, ON K1H 8L1, Canada.
Boycott KM; Department of Genetics, Children's Hospital of Eastern Ontario, Ottawa, ON K1H 8L1, Canada.
Hashem M; Deparment of Genetics, King Faisal Specialist Hospital and Research Center, Riyadh 11211, Saudi Arabia.
Han W; Computational Bioscience Research Center, Computer, Electrical, and Mathematical Sciences and Engineering Division, King Abdullah University of Science and Technology, Thuwal 23955, Saudi Arabia.
Al-Maawali A; Department of Genetics, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat 123, Oman; Genetic and Developmental Medicine Clinic, Sultan Qaboos University Hospital, Muscat 123, Oman.
Al Mahrizi F; Department of Genetics, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat 123, Oman.
Al-Thihli K; Department of Genetics, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat 123, Oman; Genetic and Developmental Medicine Clinic, Sultan Qaboos University Hospital, Muscat 123, Oman.
Gao X; Computational Bioscience Research Center, Computer, Electrical, and Mathematical Sciences and Engineering Division, King Abdullah University of Science and Technology, Thuwal 23955, Saudi Arabia. Electronic address: .
Alkuraya FS; Deparment of Genetics, King Faisal Specialist Hospital and Research Center, Riyadh 11211, Saudi Arabia; Deparment of Anatomy and Cell Biology, College of Medicine, Alfaisal University, Riyadh 11533, Saudi Arabia. Electronic address: .
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Źródło :
American journal of human genetics [Am J Hum Genet] 2020 Dec 03; Vol. 107 (6), pp. 1178-1185. Date of Electronic Publication: 2020 Nov 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Nonsense Mediated mRNA Decay*
Developmental Disabilities/*genetics
Intracellular Signaling Peptides and Proteins/*genetics
Adolescent ; Brain/abnormalities ; Child ; Child, Preschool ; Consanguinity ; Developmental Disabilities/metabolism ; Family Health ; Female ; Gene Deletion ; Genetic Linkage ; Heart Defects, Congenital/genetics ; Homozygote ; Humans ; Infant ; Male ; Pedigree ; Phenotype ; Phosphorylation ; RNA Helicases/metabolism ; RNA, Messenger/metabolism ; RNA-Seq ; Trans-Activators/metabolism ; Young Adult
Czasopismo naukowe
Tytuł :
Viral subversion of nonsense-mediated mRNA decay.
Autorzy :
Popp MW; Department of Biochemistry and Biophysics, School of Medicine and Dentistry, University of Rochester, Rochester, New York 14642, USA.; Center for RNA Biology, University of Rochester, Rochester, New York 14642, USA.
Cho H; Department of Biochemistry and Biophysics, School of Medicine and Dentistry, University of Rochester, Rochester, New York 14642, USA.; Center for RNA Biology, University of Rochester, Rochester, New York 14642, USA.
Maquat LE; Department of Biochemistry and Biophysics, School of Medicine and Dentistry, University of Rochester, Rochester, New York 14642, USA.; Center for RNA Biology, University of Rochester, Rochester, New York 14642, USA.
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Źródło :
RNA (New York, N.Y.) [RNA] 2020 Nov; Vol. 26 (11), pp. 1509-1518. Date of Electronic Publication: 2020 Jul 22.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Review
MeSH Terms :
Host-Pathogen Interactions*
Nonsense Mediated mRNA Decay*
Viruses/*metabolism
Animals ; Humans ; Plants/virology ; Protein Biosynthesis ; RNA Stability ; RNA, Messenger/metabolism ; Viral Proteins/genetics ; Virus Physiological Phenomena ; Viruses/classification ; Viruses/genetics ; Viruses/growth & development
Czasopismo naukowe
Tytuł :
UPFront and center in RNA decay: UPF1 in nonsense-mediated mRNA decay and beyond.
Autorzy :
Kim YK; Creative Research Initiatives Center for Molecular Biology of Translation, Korea University, Seoul 02841, Republic of Korea.; Division of Life Sciences, Korea University, Seoul 02841, Republic of Korea.
Maquat LE; Department of Biochemistry and Biophysics, School of Medicine and Dentistry, University of Rochester, Rochester, New York 14642, USA.; Center for RNA Biology, University of Rochester, Rochester, New York 14642, USA.
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Źródło :
RNA (New York, N.Y.) [RNA] 2019 Apr; Vol. 25 (4), pp. 407-422. Date of Electronic Publication: 2019 Jan 17.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Nonsense Mediated mRNA Decay*
Transcriptome*
RNA Helicases/*genetics
RNA, Messenger/*genetics
Trans-Activators/*genetics
Animals ; Cytoskeletal Proteins/genetics ; Cytoskeletal Proteins/metabolism ; Endonucleases ; Humans ; Nuclear Proteins/genetics ; Nuclear Proteins/metabolism ; RNA Helicases/metabolism ; RNA, Messenger/metabolism ; RNA-Binding Proteins/genetics ; RNA-Binding Proteins/metabolism ; Receptors, Glucocorticoid/genetics ; Receptors, Glucocorticoid/metabolism ; Ribonucleases/genetics ; Ribonucleases/metabolism ; Trans-Activators/metabolism ; mRNA Cleavage and Polyadenylation Factors/genetics ; mRNA Cleavage and Polyadenylation Factors/metabolism
Czasopismo naukowe
Tytuł :
Human NMD ensues independently of stable ribosome stalling.
Autorzy :
Karousis ED; Department of Chemistry and Biochemistry, University of Bern, CH-3012, Bern, Switzerland.
Gurzeler LA; Department of Chemistry and Biochemistry, University of Bern, CH-3012, Bern, Switzerland.; Graduate School for Cellular and Biomedical Sciences, University of Bern, CH-3012, Bern, Switzerland.
Annibaldis G; Department of Chemistry and Biochemistry, University of Bern, CH-3012, Bern, Switzerland.
Dreos R; Center for Integrative Genomics, Université de Lausanne, CH-1015, Lausanne, Switzerland.
Mühlemann O; Department of Chemistry and Biochemistry, University of Bern, CH-3012, Bern, Switzerland. .
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Źródło :
Nature communications [Nat Commun] 2020 Aug 17; Vol. 11 (1), pp. 4134. Date of Electronic Publication: 2020 Aug 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Nonsense Mediated mRNA Decay/*physiology
Ribosomes/*metabolism
3' Untranslated Regions/genetics ; 3' Untranslated Regions/physiology ; Codon, Terminator/genetics ; Humans ; Nonsense Mediated mRNA Decay/genetics ; RNA Stability/genetics ; RNA Stability/physiology ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Ribosomes/genetics
Czasopismo naukowe
Tytuł :
Activation and inhibition of nonsense-mediated mRNA decay control the abundance of alternative polyadenylation products.
Autorzy :
Kishor A; Biochemistry and Biophysics Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Fritz SE; Biochemistry and Biophysics Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Haque N; Biochemistry and Biophysics Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Ge Z; Biochemistry and Biophysics Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Tunc I; Bioinformatics and Computational Biology Laboratory, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Yang W; Systems Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Zhu J; Systems Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Hogg JR; Biochemistry and Biophysics Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2020 Jul 27; Vol. 48 (13), pp. 7468-7482.
Typ publikacji :
Journal Article; Research Support, N.I.H., Intramural
MeSH Terms :
Nonsense Mediated mRNA Decay*
Polyadenylation*
3' Untranslated Regions ; HEK293 Cells ; Heterogeneous-Nuclear Ribonucleoproteins/metabolism ; Humans ; Polypyrimidine Tract-Binding Protein/metabolism ; RNA Helicases/metabolism ; RNA, Messenger/metabolism ; Trans-Activators/metabolism ; Transcriptome
Czasopismo naukowe
Tytuł :
Pervasive changes of mRNA splicing in upf1 -deficient zebrafish identify rpl10a as a regulator of T cell development.
Autorzy :
Lawir DF; Department of Developmental Immunology, Max-Planck Institute of Immunobiology and Epigenetics, D-79108 Freiburg, Germany.
Sikora K; Department of Developmental Immunology, Max-Planck Institute of Immunobiology and Epigenetics, D-79108 Freiburg, Germany.
O'Meara CP; Department of Developmental Immunology, Max-Planck Institute of Immunobiology and Epigenetics, D-79108 Freiburg, Germany.
Schorpp M; Department of Developmental Immunology, Max-Planck Institute of Immunobiology and Epigenetics, D-79108 Freiburg, Germany.
Boehm T; Department of Developmental Immunology, Max-Planck Institute of Immunobiology and Epigenetics, D-79108 Freiburg, Germany .
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Jul 07; Vol. 117 (27), pp. 15799-15808. Date of Electronic Publication: 2020 Jun 22.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Glutathione/*analogs & derivatives
Nonsense Mediated mRNA Decay/*genetics
RNA Splicing/*genetics
RNA-Binding Proteins/*genetics
T-Lymphocytes/*immunology
Zebrafish Proteins/*genetics
Animals ; Codon, Nonsense/genetics ; Fertilization/genetics ; Gene Expression Regulation, Developmental/genetics ; Glutathione/genetics ; Homozygote ; Humans ; Nonsense Mediated mRNA Decay/immunology ; RNA, Messenger/genetics ; Transcription Factors/genetics ; Transcriptome/genetics ; Zebrafish/genetics
Czasopismo naukowe
Tytuł :
C9orf72 arginine-rich dipeptide repeats inhibit UPF1-mediated RNA decay via translational repression.
Autorzy :
Sun Y; Department of Neuroscience, Yale University School of Medicine, New Haven, CT, 06520, USA.; Program in Cellular Neuroscience, Neurodegeneration and Repair, Yale University School of Medicine, New Haven, CT, 06520, USA.
Eshov A; Department of Neuroscience, Yale University School of Medicine, New Haven, CT, 06520, USA.; Program in Cellular Neuroscience, Neurodegeneration and Repair, Yale University School of Medicine, New Haven, CT, 06520, USA.
Zhou J; Department of Neuroscience, Yale University School of Medicine, New Haven, CT, 06520, USA.; Program in Cellular Neuroscience, Neurodegeneration and Repair, Yale University School of Medicine, New Haven, CT, 06520, USA.
Isiktas AU; Department of Neuroscience, Yale University School of Medicine, New Haven, CT, 06520, USA.; Program in Cellular Neuroscience, Neurodegeneration and Repair, Yale University School of Medicine, New Haven, CT, 06520, USA.
Guo JU; Department of Neuroscience, Yale University School of Medicine, New Haven, CT, 06520, USA. .; Program in Cellular Neuroscience, Neurodegeneration and Repair, Yale University School of Medicine, New Haven, CT, 06520, USA. .
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Źródło :
Nature communications [Nat Commun] 2020 Jul 03; Vol. 11 (1), pp. 3354. Date of Electronic Publication: 2020 Jul 03.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Nonsense Mediated mRNA Decay*
Amyotrophic Lateral Sclerosis/*genetics
C9orf72 Protein/*genetics
Frontotemporal Dementia/*genetics
RNA Helicases/*metabolism
Trans-Activators/*metabolism
Amyotrophic Lateral Sclerosis/pathology ; Animals ; Cell Line, Tumor ; Cell Survival/genetics ; DNA Repeat Expansion ; Datasets as Topic ; Embryo, Mammalian ; Female ; Frontal Lobe/pathology ; Frontotemporal Dementia/pathology ; Humans ; Introns/genetics ; Mice ; Neurons/metabolism ; Neurons/pathology ; Primary Cell Culture ; Protein Biosynthesis ; RNA, Messenger/metabolism ; RNA-Seq ; Trans-Activators/genetics
SCR Disease Name :
Frontotemporal Dementia With Motor Neuron Disease
Czasopismo naukowe
Tytuł :
The RNA quality control pathway nonsense-mediated mRNA decay targets cellular and viral RNAs to restrict KSHV.
Autorzy :
Zhao Y; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, 37232-2363, USA.
Ye X; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, 37232-2363, USA.
Shehata M; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, 37232-2363, USA.
Dunker W; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, 37232-2363, USA.
Xie Z; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, 37232-2363, USA.
Karijolich J; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, 37232-2363, USA. .; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN, 37232-2363, USA. .; Vanderbilt-Ingram Cancer Center, Nashville, TN, 37232-2363, USA. .; Vanderbilt Institute for Infection, Immunology and Inflammation, Nashville, TN, 37232-2363, USA. .; Vanderbilt Center for Immunobiology, Nashville, TN, 37232-2363, USA. .
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Źródło :
Nature communications [Nat Commun] 2020 Jul 03; Vol. 11 (1), pp. 3345. Date of Electronic Publication: 2020 Jul 03.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation, Viral*
Nonsense Mediated mRNA Decay*
Herpesvirus 8, Human/*genetics
RNA, Viral/*metabolism
Virus Activation/*genetics
Cell Line, Tumor ; HEK293 Cells ; Herpesvirus 8, Human/metabolism ; Herpesvirus 8, Human/pathogenicity ; Host-Pathogen Interactions/genetics ; Humans ; Immediate-Early Proteins/genetics ; Immediate-Early Proteins/metabolism ; Lymphoma, Primary Effusion/genetics ; Lymphoma, Primary Effusion/virology ; RNA, Messenger/metabolism ; RNA-Seq ; Sarcoma, Kaposi/genetics ; Sarcoma, Kaposi/virology ; Trans-Activators/genetics ; Trans-Activators/metabolism ; Transcriptional Activation ; Unfolded Protein Response/genetics ; Virus Latency/genetics
Czasopismo naukowe
Tytuł :
Nonsense-mediated mRNA decay factor UPF1 promotes aggresome formation.
Autorzy :
Park Y; Creative Research Initiatives Center for Molecular Biology of Translation, Korea University, Seoul, 02841, Republic of Korea.; School of Life Sciences, Korea University, Seoul, 02841, Republic of Korea.
Park J; Creative Research Initiatives Center for Molecular Biology of Translation, Korea University, Seoul, 02841, Republic of Korea.; School of Life Sciences, Korea University, Seoul, 02841, Republic of Korea.
Hwang HJ; Creative Research Initiatives Center for Molecular Biology of Translation, Korea University, Seoul, 02841, Republic of Korea.; School of Life Sciences, Korea University, Seoul, 02841, Republic of Korea.
Kim B; Department of Physics, Pohang University of Science and Technology (POSTECH), Pohang, 37673, Republic of Korea.
Jeong K; Creative Research Initiatives Center for Molecular Biology of Translation, Korea University, Seoul, 02841, Republic of Korea.; School of Life Sciences, Korea University, Seoul, 02841, Republic of Korea.
Chang J; Creative Research Initiatives Center for Molecular Biology of Translation, Korea University, Seoul, 02841, Republic of Korea.; School of Life Sciences, Korea University, Seoul, 02841, Republic of Korea.
Lee JB; Department of Physics, Pohang University of Science and Technology (POSTECH), Pohang, 37673, Republic of Korea. .; School of Interdisciplinary Bioscience and Bioengineering, POSTECH, Pohang, 37673, Republic of Korea. .
Kim YK; Creative Research Initiatives Center for Molecular Biology of Translation, Korea University, Seoul, 02841, Republic of Korea. .; School of Life Sciences, Korea University, Seoul, 02841, Republic of Korea. .
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Źródło :
Nature communications [Nat Commun] 2020 Jun 19; Vol. 11 (1), pp. 3106. Date of Electronic Publication: 2020 Jun 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Nonsense Mediated mRNA Decay*
Proteasome Endopeptidase Complex/*metabolism
RNA Helicases/*metabolism
RNA, Messenger/*metabolism
Trans-Activators/*metabolism
Unfolded Protein Response/*genetics
Autophagy ; Codon, Nonsense ; Dynactin Complex/metabolism ; Eukaryotic Initiation Factors/metabolism ; HEK293 Cells ; HeLa Cells ; Humans ; Molecular Imaging ; Peptide Elongation Factor 1/metabolism ; Phosphorylation ; Protein Aggregates/genetics ; Single Molecule Imaging ; Ubiquitin/metabolism
Czasopismo naukowe
Tytuł :
The HIV-1 capsid-binding host factor CPSF6 is post-transcriptionally regulated by the cellular microRNA miR-125b.
Autorzy :
Chaudhuri E; Center for AIDS Health Disparities Research, Meharry Medical College, Nashville, Tennessee 37208.; Department of Biochemistry, Cancer Biology, Pharmacology and Neuroscience, Meharry Medical College, Nashville, Tennessee 37208.
Dash S; Center for AIDS Health Disparities Research, Meharry Medical College, Nashville, Tennessee 37208.; Department of Biochemistry, Cancer Biology, Pharmacology and Neuroscience, Meharry Medical College, Nashville, Tennessee 37208.; School of Biotechnology, KIIT University, Bhubaneswar, Odisha 751024, India.; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, New York 10065.
Balasubramaniam M; Center for AIDS Health Disparities Research, Meharry Medical College, Nashville, Tennessee 37208.; Department of Biochemistry, Cancer Biology, Pharmacology and Neuroscience, Meharry Medical College, Nashville, Tennessee 37208.
Padron A; Department of Biochemistry, Cancer Biology, Pharmacology and Neuroscience, Meharry Medical College, Nashville, Tennessee 37208.; Department of Microbiology, Immunology, and Physiology, Meharry Medical College, Nashville, Tennessee 37208.; School of Graduate Studies and Research, Meharry Medical College, Nashville, Tennessee 37208.
Holland J; Center for AIDS Health Disparities Research, Meharry Medical College, Nashville, Tennessee 37208.; Department of Biochemistry, Cancer Biology, Pharmacology and Neuroscience, Meharry Medical College, Nashville, Tennessee 37208.
Sowd GA; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215.; Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115.
Villalta F; Center for AIDS Health Disparities Research, Meharry Medical College, Nashville, Tennessee 37208.; Department of Microbiology, Immunology, and Physiology, Meharry Medical College, Nashville, Tennessee 37208.
Engelman AN; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215.; Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115.
Pandhare J; Center for AIDS Health Disparities Research, Meharry Medical College, Nashville, Tennessee 37208.; Department of Microbiology, Immunology, and Physiology, Meharry Medical College, Nashville, Tennessee 37208.; School of Graduate Studies and Research, Meharry Medical College, Nashville, Tennessee 37208.
Dash C; Center for AIDS Health Disparities Research, Meharry Medical College, Nashville, Tennessee 37208 .; Department of Biochemistry, Cancer Biology, Pharmacology and Neuroscience, Meharry Medical College, Nashville, Tennessee 37208.; School of Graduate Studies and Research, Meharry Medical College, Nashville, Tennessee 37208.
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2020 Apr 10; Vol. 295 (15), pp. 5081-5094. Date of Electronic Publication: 2020 Mar 09.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
3' Untranslated Regions/*genetics
Capsid/*metabolism
HIV Infections/*virology
HIV-1/*physiology
MicroRNAs/*genetics
mRNA Cleavage and Polyadenylation Factors/*metabolism
Binding Sites ; HIV Infections/genetics ; HIV Infections/metabolism ; Humans ; MicroRNAs/metabolism ; Mutation ; Virus Integration ; mRNA Cleavage and Polyadenylation Factors/chemistry ; mRNA Cleavage and Polyadenylation Factors/genetics
Czasopismo naukowe
Tytuł :
Mechanisms and Regulation of Nonsense-Mediated mRNA Decay and Nonsense-Associated Altered Splicing in Lymphocytes.
Autorzy :
Lambert JM; Unit CNRS 7276 - INSERM U1262 - Limoges University, 2 rue du Docteur Marcland, 87025 Limoges, France.
Ashi MO; Unit CNRS 7276 - INSERM U1262 - Limoges University, 2 rue du Docteur Marcland, 87025 Limoges, France.
Srour N; Unit CNRS 7276 - INSERM U1262 - Limoges University, 2 rue du Docteur Marcland, 87025 Limoges, France.; Present address: Segal Cancer Center, Lady Davis Institute for Medical Research and Departments of Oncology and Medicine, McGill University, Montréal, QC H3T 1E2, Canada.
Delpy L; Unit CNRS 7276 - INSERM U1262 - Limoges University, 2 rue du Docteur Marcland, 87025 Limoges, France.
Saulière J; Unit CNRS 7276 - INSERM U1262 - Limoges University, 2 rue du Docteur Marcland, 87025 Limoges, France.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Feb 17; Vol. 21 (4). Date of Electronic Publication: 2020 Feb 17.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Alternative Splicing*
Nonsense Mediated mRNA Decay*
B-Lymphocytes/*metabolism
Codon, Nonsense/*genetics
Cell Differentiation ; Codon, Nonsense/metabolism ; Frameshift Mutation ; Gain of Function Mutation ; Plasma Cells/metabolism ; RNA Stability ; Receptors, Antigen, T-Cell/genetics ; Receptors, Antigen, T-Cell/metabolism ; Up-Regulation
Czasopismo naukowe
Tytuł :
Acute myeloid leukemia with a novel CPSF6-RARG variant is sensitive to homoharringtonine and cytarabine chemotherapy.
Autorzy :
Zhang Z; Department of Clinical Laboratory, The First Affiliated Hospital of Nanchang University, Nanchang, China.; Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Jiang M; Department of Clinical Laboratory, The First Affiliated Hospital of Nanchang University, Nanchang, China.
Borthakur G; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Luan S; Department of Pathology, The First Affiliated Hospital of Nanchang University, Nanchang, China.
Huang X; Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, Texas.; Department of Hematology, The First Affiliated Hospital of Nanchang University, Nanchang, China.
Tang G; Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Xu Q; Department of Hematology, The First Affiliated Hospital of Nanchang University, Nanchang, China.
Ji D; Department of Hematology, The First Affiliated Hospital of Nanchang University, Nanchang, China.
Boyer AD; Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Li F; Department of Hematology, The First Affiliated Hospital of Nanchang University, Nanchang, China.
Huang R; Department of Hematology, The First Affiliated Hospital of Nanchang University, Nanchang, China.
You MJ; Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
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Źródło :
American journal of hematology [Am J Hematol] 2020 Feb; Vol. 95 (2), pp. E48-E51. Date of Electronic Publication: 2019 Dec 31.
Typ publikacji :
Case Reports; Letter; Research Support, Non-U.S. Gov't
MeSH Terms :
Leukemia, Myeloid, Acute*/drug therapy
Leukemia, Myeloid, Acute*/genetics
Leukemia, Myeloid, Acute*/metabolism
Leukemia, Myeloid, Acute*/pathology
Oncogene Proteins, Fusion*/genetics
Oncogene Proteins, Fusion*/metabolism
Receptors, Retinoic Acid*/genetics
Receptors, Retinoic Acid*/metabolism
mRNA Cleavage and Polyadenylation Factors*/genetics
mRNA Cleavage and Polyadenylation Factors*/metabolism
Antineoplastic Combined Chemotherapy Protocols/*administration & dosage
Cytarabine/administration & dosage ; Homoharringtonine/administration & dosage ; Humans ; Male ; Middle Aged
Raport
Tytuł :
Divergent effects of translation termination factor eRF3A and nonsense-mediated mRNA decay factor UPF1 on the expression of uORF carrying mRNAs and ribosome protein genes.
Autorzy :
Aliouat A; Sorbonne Université, CNRS, Biological Adaptation and Aging, B2A, 75005 Paris, France.
Hatin I; Institute for Integrative Biology of the Cell (I2BC), CEA, CNRS, Univ Paris Sud, Université Paris-Saclay, Gif sur Yvette cedex, France.
Bertin P; Institute for Integrative Biology of the Cell (I2BC), CEA, CNRS, Univ Paris Sud, Université Paris-Saclay, Gif sur Yvette cedex, France.
François P; Institute for Integrative Biology of the Cell (I2BC), CEA, CNRS, Univ Paris Sud, Université Paris-Saclay, Gif sur Yvette cedex, France.
Stierlé V; Sorbonne Université, CNRS, Biological Adaptation and Aging, B2A, 75005 Paris, France.
Namy O; Institute for Integrative Biology of the Cell (I2BC), CEA, CNRS, Univ Paris Sud, Université Paris-Saclay, Gif sur Yvette cedex, France.
Salhi S; Sorbonne Université, CNRS, Biological Adaptation and Aging, B2A, 75005 Paris, France.
Jean-Jean O; Sorbonne Université, CNRS, Biological Adaptation and Aging, B2A, 75005 Paris, France.
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Źródło :
RNA biology [RNA Biol] 2020 Feb; Vol. 17 (2), pp. 227-239. Date of Electronic Publication: 2019 Oct 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation*
Nonsense Mediated mRNA Decay*
Open Reading Frames/*genetics
Peptide Termination Factors/*metabolism
RNA Helicases/*genetics
RNA, Messenger/*genetics
Ribosomal Proteins/*genetics
Trans-Activators/*genetics
Czasopismo naukowe
Tytuł :
CPSF7 regulates liver cancer growth and metastasis by facilitating WWP2-FL and targeting the WWP2/PTEN/AKT signaling pathway.
Autorzy :
Fang S; Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research, the Fifth Affiliated Hospital of Wenzhou Medical University/Affiliated Lishui Hospital of Zhejiang University/The Central Hospital of Zhejiang Lishui, Lishui 323000, China; Department of Radiology, Affiliated Lishui Hospital of Zhejiang University/the Fifth Affiliated Hospital of Wenzhou Medical University/The Central Hospital of Zhejiang Lishui, Lishui 323000, China.
Zhang D; Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research, the Fifth Affiliated Hospital of Wenzhou Medical University/Affiliated Lishui Hospital of Zhejiang University/The Central Hospital of Zhejiang Lishui, Lishui 323000, China; Department of Radiology, Affiliated Lishui Hospital of Zhejiang University/the Fifth Affiliated Hospital of Wenzhou Medical University/The Central Hospital of Zhejiang Lishui, Lishui 323000, China.
Weng W; Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research, the Fifth Affiliated Hospital of Wenzhou Medical University/Affiliated Lishui Hospital of Zhejiang University/The Central Hospital of Zhejiang Lishui, Lishui 323000, China; Department of Radiology, Affiliated Lishui Hospital of Zhejiang University/the Fifth Affiliated Hospital of Wenzhou Medical University/The Central Hospital of Zhejiang Lishui, Lishui 323000, China.
Lv X; Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research, the Fifth Affiliated Hospital of Wenzhou Medical University/Affiliated Lishui Hospital of Zhejiang University/The Central Hospital of Zhejiang Lishui, Lishui 323000, China; Department of Radiology, Affiliated Lishui Hospital of Zhejiang University/the Fifth Affiliated Hospital of Wenzhou Medical University/The Central Hospital of Zhejiang Lishui, Lishui 323000, China.
Zheng L; Lishui Hospital of Zhejiang University, China.
Chen M; Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research, the Fifth Affiliated Hospital of Wenzhou Medical University/Affiliated Lishui Hospital of Zhejiang University/The Central Hospital of Zhejiang Lishui, Lishui 323000, China; Department of Radiology, Affiliated Lishui Hospital of Zhejiang University/the Fifth Affiliated Hospital of Wenzhou Medical University/The Central Hospital of Zhejiang Lishui, Lishui 323000, China.
Fan X; Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research, the Fifth Affiliated Hospital of Wenzhou Medical University/Affiliated Lishui Hospital of Zhejiang University/The Central Hospital of Zhejiang Lishui, Lishui 323000, China; Department of Radiology, Affiliated Lishui Hospital of Zhejiang University/the Fifth Affiliated Hospital of Wenzhou Medical University/The Central Hospital of Zhejiang Lishui, Lishui 323000, China.
Mao J; Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research, the Fifth Affiliated Hospital of Wenzhou Medical University/Affiliated Lishui Hospital of Zhejiang University/The Central Hospital of Zhejiang Lishui, Lishui 323000, China; Department of Radiology, Affiliated Lishui Hospital of Zhejiang University/the Fifth Affiliated Hospital of Wenzhou Medical University/The Central Hospital of Zhejiang Lishui, Lishui 323000, China.
Mao C; Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research, the Fifth Affiliated Hospital of Wenzhou Medical University/Affiliated Lishui Hospital of Zhejiang University/The Central Hospital of Zhejiang Lishui, Lishui 323000, China; Department of Radiology, Affiliated Lishui Hospital of Zhejiang University/the Fifth Affiliated Hospital of Wenzhou Medical University/The Central Hospital of Zhejiang Lishui, Lishui 323000, China.
Ye Y; Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research, the Fifth Affiliated Hospital of Wenzhou Medical University/Affiliated Lishui Hospital of Zhejiang University/The Central Hospital of Zhejiang Lishui, Lishui 323000, China; Department of Radiology, Affiliated Lishui Hospital of Zhejiang University/the Fifth Affiliated Hospital of Wenzhou Medical University/The Central Hospital of Zhejiang Lishui, Lishui 323000, China.
Xu M; Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research, the Fifth Affiliated Hospital of Wenzhou Medical University/Affiliated Lishui Hospital of Zhejiang University/The Central Hospital of Zhejiang Lishui, Lishui 323000, China; Department of Radiology, Affiliated Lishui Hospital of Zhejiang University/the Fifth Affiliated Hospital of Wenzhou Medical University/The Central Hospital of Zhejiang Lishui, Lishui 323000, China. Electronic address: .
Ji J; Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research, the Fifth Affiliated Hospital of Wenzhou Medical University/Affiliated Lishui Hospital of Zhejiang University/The Central Hospital of Zhejiang Lishui, Lishui 323000, China; Department of Radiology, Affiliated Lishui Hospital of Zhejiang University/the Fifth Affiliated Hospital of Wenzhou Medical University/The Central Hospital of Zhejiang Lishui, Lishui 323000, China. Electronic address: .
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Źródło :
Biochimica et biophysica acta. Molecular cell research [Biochim Biophys Acta Mol Cell Res] 2020 Feb; Vol. 1867 (2), pp. 118624. Date of Electronic Publication: 2019 Dec 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Liver Neoplasms/*pathology
PTEN Phosphohydrolase/*metabolism
Proto-Oncogene Proteins c-akt/*metabolism
RNA Recognition Motif Proteins/*metabolism
Ubiquitin-Protein Ligases/*metabolism
mRNA Cleavage and Polyadenylation Factors/*metabolism
Animals ; Cell Line, Tumor ; Cell Movement ; Cell Proliferation ; Female ; Humans ; Liver Neoplasms/metabolism ; Male ; Mice ; Mice, Nude ; Middle Aged ; Protein Isoforms/genetics ; Protein Isoforms/metabolism ; RNA Interference ; RNA Recognition Motif Proteins/genetics ; RNA, Small Interfering/metabolism ; Signal Transduction ; Transplantation, Heterologous ; Ubiquitin-Protein Ligases/genetics ; mRNA Cleavage and Polyadenylation Factors/antagonists & inhibitors ; mRNA Cleavage and Polyadenylation Factors/genetics
Czasopismo naukowe
Tytuł :
[The NMD escape mechanism and its application in disease therapy].
Autorzy :
Cheng MM; Department of Medical Genetics, Capital Institute of Pediatrics, Beijing 100020, China.
Cao YY; Department of Medical Genetics, Capital Institute of Pediatrics, Beijing 100020, China.
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Źródło :
Yi chuan = Hereditas [Yi Chuan] 2020 Apr 20; Vol. 42 (4), pp. 354-362.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Codon, Nonsense*
Codon, Terminator*
Nonsense Mediated mRNA Decay*
Humans ; RNA, Messenger
Czasopismo naukowe
Tytuł :
Security Notice: This Plant Immunity Is under mRNA Surveillance.
Autorzy :
Kawa D; Department of Plant Biology and Genome CenterUniversity of California, Davis .
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Źródło :
The Plant cell [Plant Cell] 2020 Apr; Vol. 32 (4), pp. 803-804. Date of Electronic Publication: 2020 Feb 28.
Typ publikacji :
Editorial; Comment
MeSH Terms :
Nonsense Mediated mRNA Decay*
Pathogen-Associated Molecular Pattern Molecules*
Plant Immunity ; RNA, Messenger
Opinia redakcyjna
Tytuł :
Aberrant expression of the UPF1 RNA surveillance gene disturbs keratinocyte homeostasis by stabilizing AREG.
Autorzy :
Yaojia Cheng YX; Institute of Aging Research, School of Medicine, Hangzhou Normal University, Hangzhou, Zhejiang 311121, P.R. China.
Lu Q; Institute of Aging Research, School of Medicine, Hangzhou Normal University, Hangzhou, Zhejiang 311121, P.R. China.
Shi N; Institute of Aging Research, School of Medicine, Hangzhou Normal University, Hangzhou, Zhejiang 311121, P.R. China.
Zhou Q; Department of Dermatology, Affiliated Hospital, Ningbo University, Ningbo, Zhejiang 315211, P.R. China.
Rong J; Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, P.R. China.
Li L; Information Centre, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, P.R. China.
Wang L; Institute of Aging Research, School of Medicine, Hangzhou Normal University, Hangzhou, Zhejiang 311121, P.R. China.
Liu C; Institute of Aging Research, School of Medicine, Hangzhou Normal University, Hangzhou, Zhejiang 311121, P.R. China.
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Źródło :
International journal of molecular medicine [Int J Mol Med] 2020 Apr; Vol. 45 (4), pp. 1163-1175. Date of Electronic Publication: 2020 Feb 05.
Typ publikacji :
Journal Article
MeSH Terms :
Nonsense Mediated mRNA Decay*
Signal Transduction*
Amphiregulin/*metabolism
Keratinocytes/*metabolism
Psoriasis/*metabolism
RNA Helicases/*metabolism
Trans-Activators/*biosynthesis
Trans-Activators/*metabolism
Amphiregulin/genetics ; Animals ; Disease Models, Animal ; Female ; Humans ; Keratinocytes/pathology ; Male ; Mice ; Protein Stability ; Psoriasis/genetics ; Psoriasis/pathology ; RNA Helicases/genetics ; Trans-Activators/genetics
Czasopismo naukowe
Tytuł :
A Cancer-Specific Ubiquitin Ligase Drives mRNA Alternative Polyadenylation by Ubiquitinating the mRNA 3' End Processing Complex.
Autorzy :
Yang SW; Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Li L; Department of Biological Chemistry, School of Medicine, University of California, Irvine, Irvine, CA 92697, USA; Division of Biostatistics, Dan L. Duncan Cancer Center and Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.
Connelly JP; Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Porter SN; Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Kodali K; Departments of Structural Biology and Developmental Neurobiology, Center for Proteomics and Metabolomics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Gan H; Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Park JM; Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Tacer KF; Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Tillman H; Veterinary Pathology Core, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Peng J; Departments of Structural Biology and Developmental Neurobiology, Center for Proteomics and Metabolomics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Pruett-Miller SM; Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Li W; Department of Biological Chemistry, School of Medicine, University of California, Irvine, Irvine, CA 92697, USA; Division of Biostatistics, Dan L. Duncan Cancer Center and Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.
Potts PR; Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2020 Mar 19; Vol. 77 (6), pp. 1206-1221.e7. Date of Electronic Publication: 2020 Jan 21.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
3' Untranslated Regions/*genetics
Antigens, Neoplasm/*metabolism
Lung Neoplasms/*pathology
Neoplasm Proteins/*metabolism
Ovarian Neoplasms/*pathology
RNA, Messenger/*metabolism
Ubiquitin/*metabolism
mRNA Cleavage and Polyadenylation Factors/*metabolism
Animals ; Antigens, Neoplasm/genetics ; Apoptosis ; Biomarkers, Tumor ; Carcinogenesis ; Carcinoma, Squamous Cell/genetics ; Carcinoma, Squamous Cell/metabolism ; Carcinoma, Squamous Cell/pathology ; Cell Proliferation ; Cleavage And Polyadenylation Specificity Factor/genetics ; Cleavage And Polyadenylation Specificity Factor/metabolism ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Lung Neoplasms/genetics ; Lung Neoplasms/metabolism ; Male ; Mice ; Mice, Inbred NOD ; Mice, SCID ; Neoplasm Proteins/genetics ; Ovarian Neoplasms/genetics ; Ovarian Neoplasms/metabolism ; Polyadenylation ; RNA Splicing ; RNA, Messenger/genetics ; Tumor Cells, Cultured ; Tumor Suppressor Proteins/genetics ; Tumor Suppressor Proteins/metabolism ; Ubiquitin-Protein Ligases/genetics ; Ubiquitin-Protein Ligases/metabolism ; Ubiquitination ; Xenograft Model Antitumor Assays ; mRNA Cleavage and Polyadenylation Factors/genetics
Czasopismo naukowe

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