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Tytuł :
Chemically modified mRNA beyond COVID-19: Potential preventive and therapeutic applications for targeting chronic diseases.
Autorzy :
Elkhalifa D; Department of Pharmacy, Aspetar Orthopedic and Sports Medicine Hospital, Doha, Qatar.
Rayan M; Department of Pharmaceutical Sciences, College of Pharmacy, QU Health, Qatar University, Doha, Qatar.
Negmeldin AT; Department of Pharmaceutical Sciences, College of Pharmacy and Thumbay Research Institute for Precision Medicine, Gulf Medical University, Ajman, United Arab Emirates; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
Elhissi A; Department of Pharmaceutical Sciences, College of Pharmacy, QU Health, Qatar University, Doha, Qatar; Biomedical and Pharmaceutical Research Unit, QU Health, Qatar University, Doha, Qatar; Office of the Vice President for Research and Graduate Studies, Qatar University, Doha, Qatar.
Khalil A; Department of Pharmaceutical Sciences, College of Pharmacy, QU Health, Qatar University, Doha, Qatar; Biomedical and Pharmaceutical Research Unit, QU Health, Qatar University, Doha, Qatar.
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Źródło :
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2022 Jan; Vol. 145, pp. 112385. Date of Electronic Publication: 2021 Oct 28.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Vaccines, Synthetic*/administration & dosage
Vaccines, Synthetic*/immunology
mRNA Vaccines*/administration & dosage
mRNA Vaccines*/immunology
COVID-19/*prevention & control
Chronic Disease/*prevention & control
Chronic Disease/*therapy
Genetic Therapy/*methods
Immunotherapy/*methods
Pandemics/*prevention & control
RNA, Messenger/*chemistry
SARS-CoV-2/*immunology
Biological Availability ; Drug Carriers ; Forecasting ; Gene Transfer Techniques ; Genetic Vectors/administration & dosage ; Genetic Vectors/therapeutic use ; Humans ; Immunotherapy, Active ; Nanoparticle Drug Delivery System ; RNA Stability ; RNA, Messenger/administration & dosage ; RNA, Messenger/immunology ; RNA, Messenger/therapeutic use ; SARS-CoV-2/genetics ; Vaccine Development
Czasopismo naukowe
Tytuł :
Architectural and functional details of CF IA proteins involved in yeast 3'-end pre-mRNA processing and its significance for eukaryotes: A concise review.
Autorzy :
Kaur M; Department of Biophysics, Panjab University, Chandigarh 160014, India.
Sharma A; Department of Biophysics, Panjab University, Chandigarh 160014, India; University Institute of Pharmaceutical Sciences (UIPS), Panjab University, Chandigarh 160014, India.
Singh G; University Institute of Pharmaceutical Sciences (UIPS), Panjab University, Chandigarh 160014, India.
Kumar S; Department of Biotechnology, Panjab University, Chandigarh 160014, India; National Centre for Cell Science, NCCS Complex, S. P. Pune University Campus, Ganeshkhind, Pune, Maharashtra 411007, India.
Barnwal RP; Department of Biophysics, Panjab University, Chandigarh 160014, India. Electronic address: .
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Źródło :
International journal of biological macromolecules [Int J Biol Macromol] 2021 Dec 15; Vol. 193 (Pt A), pp. 387-400. Date of Electronic Publication: 2021 Oct 23.
Typ publikacji :
Journal Article; Review
MeSH Terms :
mRNA Cleavage and Polyadenylation Factors*/chemistry
mRNA Cleavage and Polyadenylation Factors*/physiology
RNA Precursors/*metabolism
Saccharomyces cerevisiae/*metabolism
3' Untranslated Regions ; Humans ; Polyadenylation
Czasopismo naukowe
Tytuł :
mRNA Vaccines to Protect Against Diseases.
Autorzy :
Thomas S; Lankenau Institute for Medical Research, Wynnewood, PA, USA. .
Abraham A; Lankenau Institute for Medical Research, Wynnewood, PA, USA.
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Źródło :
Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2022; Vol. 2410, pp. 111-129.
Typ publikacji :
Journal Article
MeSH Terms :
Vaccine Development*
Viral Vaccines*/genetics
mRNA Vaccines*
COVID-19/prevention & control ; COVID-19 Vaccines ; Humans ; Liposomes ; Nanoparticles ; Spike Glycoprotein, Coronavirus
Czasopismo naukowe
Tytuł :
A Single Dose SARS-CoV-2 Replicon RNA Vaccine Induces Cellular and Humoral Immune Responses in Simian Immunodeficiency Virus Infected and Uninfected Pigtail Macaques.
Autorzy :
O'Connor MA; Department of Microbiology, University of Washington, Seattle, WA, United States.; Washington National Primate Research Center, University of Washington, Seattle, WA, United States.
Erasmus JH; Department of Microbiology, University of Washington, Seattle, WA, United States.; HDT Bio, Seattle, WA, United States.
Randall S; Department of Microbiology, University of Washington, Seattle, WA, United States.
Archer J; Department of Microbiology, University of Washington, Seattle, WA, United States.; HDT Bio, Seattle, WA, United States.
Lewis TB; Department of Microbiology, University of Washington, Seattle, WA, United States.; Washington National Primate Research Center, University of Washington, Seattle, WA, United States.
Brown B; Department of Microbiology, University of Washington, Seattle, WA, United States.; Washington National Primate Research Center, University of Washington, Seattle, WA, United States.
Fredericks M; Department of Microbiology, University of Washington, Seattle, WA, United States.; Washington National Primate Research Center, University of Washington, Seattle, WA, United States.
Groenier S; Department of Microbiology, University of Washington, Seattle, WA, United States.
Iwayama N; Washington National Primate Research Center, University of Washington, Seattle, WA, United States.
Ahrens C; Washington National Primate Research Center, University of Washington, Seattle, WA, United States.
Garrison W; Washington National Primate Research Center, University of Washington, Seattle, WA, United States.
Wangari S; Washington National Primate Research Center, University of Washington, Seattle, WA, United States.
Guerriero KA; Washington National Primate Research Center, University of Washington, Seattle, WA, United States.
Fuller DH; Department of Microbiology, University of Washington, Seattle, WA, United States.; Washington National Primate Research Center, University of Washington, Seattle, WA, United States.
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Źródło :
Frontiers in immunology [Front Immunol] 2021 Dec 21; Vol. 12, pp. 800723. Date of Electronic Publication: 2021 Dec 21 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Immunogenicity, Vaccine*
Vaccine Efficacy*
COVID-19/*prevention & control
COVID-19 Vaccines/*administration & dosage
Immunity, Cellular/*drug effects
Immunity, Humoral/*drug effects
Simian Acquired Immunodeficiency Syndrome/*immunology
Simian Immunodeficiency Virus/*immunology
Spike Glycoprotein, Coronavirus/*administration & dosage
mRNA Vaccines/*administration & dosage
Animals ; Antibodies, Neutralizing/blood ; Antibodies, Viral/blood ; COVID-19/immunology ; COVID-19/virology ; COVID-19 Vaccines/genetics ; COVID-19 Vaccines/immunology ; Cells, Cultured ; Disease Models, Animal ; Host-Pathogen Interactions ; Immunocompromised Host ; Macaca nemestrina ; Male ; Simian Acquired Immunodeficiency Syndrome/blood ; Simian Acquired Immunodeficiency Syndrome/virology ; Simian Immunodeficiency Virus/pathogenicity ; Spike Glycoprotein, Coronavirus/genetics ; Spike Glycoprotein, Coronavirus/immunology ; Th1 Cells/drug effects ; Th1 Cells/immunology ; Th1 Cells/virology ; Time Factors ; Vaccination ; mRNA Vaccines/genetics ; mRNA Vaccines/immunology
Czasopismo naukowe
Tytuł :
Recent Advances in the Noninvasive Delivery of mRNA.
Autorzy :
Qin M; Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610064, P. R. China.
Du G; Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610064, P. R. China.
Sun X; Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610064, P. R. China.
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Źródło :
Accounts of chemical research [Acc Chem Res] 2021 Dec 07; Vol. 54 (23), pp. 4262-4271. Date of Electronic Publication: 2021 Nov 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Drug Delivery Systems/*methods
mRNA Vaccines/*chemistry
Administration, Cutaneous ; Administration, Inhalation ; Animals ; COVID-19/prevention & control ; COVID-19/virology ; Humans ; SARS-CoV-2/isolation & purification ; mRNA Vaccines/administration & dosage ; mRNA Vaccines/immunology
Czasopismo naukowe
Tytuł :
Molecular Determinants and Specificity of mRNA with Alternatively-Spliced UPF1 Isoforms, Influenced by an Insertion in the 'Regulatory Loop'.
Autorzy :
Padariya M; International Centre for Cancer Vaccine Science, University of Gdansk, ul. Kładki 24, 80-822 Gdansk, Poland.
Fahraeus R; International Centre for Cancer Vaccine Science, University of Gdansk, ul. Kładki 24, 80-822 Gdansk, Poland.; Inserm UMRS1131, Institut de Génétique Moléculaire, Université Paris 7, Hôpital St. Louis, F-75010 Paris, France.; Department of Medical Biosciences, Umeå University, Building 6M, 90185 Umeå, Sweden.; Regional Centre for Applied Molecular Oncology (RECAMO), Masaryk Memorial Cancer Institute, Zlutykopec 7, 65653 Brno, Czech Republic.
Hupp T; International Centre for Cancer Vaccine Science, University of Gdansk, ul. Kładki 24, 80-822 Gdansk, Poland.; Institute of Genetics and Cancer, University of Edinburgh, Edinburgh EH4 2XR, UK.
Kalathiya U; International Centre for Cancer Vaccine Science, University of Gdansk, ul. Kładki 24, 80-822 Gdansk, Poland.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Nov 25; Vol. 22 (23). Date of Electronic Publication: 2021 Nov 25.
Typ publikacji :
Journal Article
MeSH Terms :
Alternative Splicing*
Gene Expression Regulation*
Nonsense Mediated mRNA Decay*
RNA Helicases/*metabolism
RNA, Messenger/*metabolism
Trans-Activators/*metabolism
Humans ; Phosphorylation ; Protein Binding ; Protein Isoforms ; RNA Helicases/genetics ; RNA, Messenger/genetics ; Trans-Activators/genetics
Czasopismo naukowe
Tytuł :
Inhibition of nonsense-mediated decay rescues p53β/γ isoform expression and activates the p53 pathway in MDM2-overexpressing and select p53-mutant cancers.
Autorzy :
Gudikote JP; Department of Thoracic Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Cascone T; Department of Thoracic Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Poteete A; Department of Thoracic Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Sitthideatphaiboon P; Department of Thoracic Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Wu Q; Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Morikawa N; Department of Thoracic Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Zhang F; Department of Thoracic Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Peng S; Department of Thoracic Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Tong P; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Li L; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Shen L; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Nilsson M; Department of Thoracic Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Jones P; Institute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Sulman EP; Department of Radiation Oncology and Brain and Spine Tumor Center, Laura and Isaac Perlmutter Cancer Center, NYU Langone School of Medicine, New York, New York, USA.
Wang J; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA; The University of Texas MD Anderson Cancer Center Graduate School of Biomedical Sciences, Houston, Texas, USA.
Bourdon JC; Cellular Division, Ninewells Hospital Campus, School of Medicine, University of Dundee, Dundee, UK.
Johnson FM; Department of Thoracic Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA; The University of Texas MD Anderson Cancer Center Graduate School of Biomedical Sciences, Houston, Texas, USA.
Heymach JV; Department of Thoracic Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA. Electronic address: .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2021 Nov; Vol. 297 (5), pp. 101163. Date of Electronic Publication: 2021 Sep 03.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation, Neoplastic*
Mutation*
Nonsense Mediated mRNA Decay*
Proto-Oncogene Proteins c-mdm2*/genetics
Proto-Oncogene Proteins c-mdm2*/metabolism
Tumor Suppressor Protein p53*/biosynthesis
Tumor Suppressor Protein p53*/genetics
A549 Cells ; Animals ; Humans ; Mice ; Protein Isoforms/biosynthesis ; Protein Isoforms/genetics
Czasopismo naukowe
Tytuł :
A new self-attenuated therapeutic influenza vaccine that uses host cell-restricted attenuation by artificial microRNAs.
Autorzy :
Wen K; Center of Emphasis in Infectious Diseases, Department of Molecular and Translational Medicine, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center El Paso, El Paso, TX 79905, USA.
Wang H; Center of Emphasis in Infectious Diseases, Department of Molecular and Translational Medicine, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center El Paso, El Paso, TX 79905, USA; Affiliated Stomatology Hospital of Guangzhou Medical University, Guangdong Engineering Research Center of Restoration and Reconstruction, Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou, Guangdong 510182, China.
Chen Y; Center of Emphasis in Infectious Diseases, Department of Molecular and Translational Medicine, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center El Paso, El Paso, TX 79905, USA.
Yang H; Center of Emphasis in Infectious Diseases, Department of Molecular and Translational Medicine, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center El Paso, El Paso, TX 79905, USA; Affiliated Stomatology Hospital of Guangzhou Medical University, Guangdong Engineering Research Center of Restoration and Reconstruction, Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou, Guangdong 510182, China.
Zheng Z; Center of Emphasis in Infectious Diseases, Department of Molecular and Translational Medicine, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center El Paso, El Paso, TX 79905, USA; Affiliated Stomatology Hospital of Guangzhou Medical University, Guangdong Engineering Research Center of Restoration and Reconstruction, Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou, Guangdong 510182, China.
Yan Y; Center of Emphasis in Infectious Diseases, Department of Molecular and Translational Medicine, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center El Paso, El Paso, TX 79905, USA; Affiliated Stomatology Hospital of Guangzhou Medical University, Guangdong Engineering Research Center of Restoration and Reconstruction, Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou, Guangdong 510182, China.
Realivazquez Pena A; Center of Emphasis in Infectious Diseases, Department of Molecular and Translational Medicine, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center El Paso, El Paso, TX 79905, USA; Graduate School of Biomedical Sciences, Texas Tech University Health Sciences Center El Paso, El Paso, TX 79905, USA.
Zeng M; Center of Emphasis in Infectious Diseases, Department of Molecular and Translational Medicine, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center El Paso, El Paso, TX 79905, USA; Graduate School of Biomedical Sciences, Texas Tech University Health Sciences Center El Paso, El Paso, TX 79905, USA. Electronic address: .
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Źródło :
International journal of pharmaceutics [Int J Pharm] 2022 Jan 25; Vol. 612, pp. 121325. Date of Electronic Publication: 2021 Dec 06.
Typ publikacji :
Journal Article
MeSH Terms :
Influenza Vaccines*
Influenza, Human*/prevention & control
MicroRNAs*/genetics
Orthomyxoviridae Infections*/prevention & control
mRNA Vaccines*
Animals ; Antigenic Drift and Shift ; Humans ; Mice ; Vaccines, Attenuated
Czasopismo naukowe
Tytuł :
COVID-19 and novel mRNA vaccines in pregnancy: an updated literature review.
Autorzy :
Joubert E; Campbell University School of Osteopathic Medicine, Lillington, NC, USA.
Kekeh AC; Edward Via College of Osteopathic Medicine-Virginia Campus, Blacksburg, VA, USA.
Amin CN; Piedmont Family Medicine, Salisbury, NC, USA.
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Źródło :
BJOG : an international journal of obstetrics and gynaecology [BJOG] 2022 Jan; Vol. 129 (1), pp. 21-28. Date of Electronic Publication: 2021 Nov 01.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Prenatal Care*
COVID-19/*prevention & control
COVID-19 Vaccines/*administration & dosage
Pregnancy Complications, Infectious/*prevention & control
mRNA Vaccines/*administration & dosage
COVID-19 Vaccines/adverse effects ; Female ; Humans ; Pregnancy ; mRNA Vaccines/adverse effects
Czasopismo naukowe
Tytuł :
Side effects of messenger RNA vaccines and prior history of COVID-19, a cross-sectional study.
Autorzy :
Kadali RAK; Department of Internal Medicine, Harnett Hospitalist Group, Campbell University Jerry M. Wallace School of Osteopathic Medicine, Lillington, NC. Electronic address: .
Janagama R; Department of Pediatrics, Kidzcare Pediatrics, Sanford, NC.
Yedlapati SH; Department of Internal Medicine, Erie County Medical Center, Buffalo, NY.
Kanike N; Division of Neonatology, Department of Pediatrics, Indiana University School of Medicine, Newburgh, IN.
Gajula V; Division of Pediatric Critical Care Medicine, Department of Pediatrics, The University of Mississippi Medical Center, Jackson, MS.
Madathala RR; Department of Internal Medicine, Mayo Clinic, Rochester, MN.
Poddar S; Psychiatry Program, California Health Care Facility, Stockton, CA.
Sukka N; Department of Internal Medicine, Vidant medical group, Lenoir Memorial hospital, Kinston, NC.
Jogu HR; Department of Internal Medicine, Vidant medical group, Greenville, NC.
Racherla S; Department of Pathology and Laboratory Medicine, University of California, Davis, CA.
Shah I; Rheumatology Program, Kent Hospital, Warwick, Rhode Island, USA.
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Źródło :
American journal of infection control [Am J Infect Control] 2022 Jan; Vol. 50 (1), pp. 8-14. Date of Electronic Publication: 2021 Oct 28.
Typ publikacji :
Journal Article
MeSH Terms :
COVID-19*
mRNA Vaccines*
Cross-Sectional Studies ; Humans ; SARS-CoV-2 ; United States ; Vaccines, Synthetic
Czasopismo naukowe
Tytuł :
Detection of persistent SARS-CoV-2 IgG antibodies in oral mucosal fluid and upper respiratory tract specimens following COVID-19 mRNA vaccination.
Autorzy :
Mades A; Curative Inc., San Dimas, CA, 91773, USA.
Chellamathu P; Curative Inc., San Dimas, CA, 91773, USA.
Kojima N; Department of Medicine, University of California Los Angeles, Los Angeles, CA, 90095, USA. .
Lopez L; Curative Inc., San Dimas, CA, 91773, USA.
MacMullan MA; Curative Inc., San Dimas, CA, 91773, USA.; Mork Family Department of Chemical Engineering and Materials Science, Viterbi School of Engineering, University of Southern California, Los Angeles, CA, 90089, USA.
Denny N; Curative Inc., San Dimas, CA, 91773, USA.
Angel AN; Curative Inc., San Dimas, CA, 91773, USA.
Santacruz M; Curative Inc., San Dimas, CA, 91773, USA.
Casian JG; Curative Inc., San Dimas, CA, 91773, USA.
Brobeck M; Curative Inc., San Dimas, CA, 91773, USA.
Nirema N; Curative Inc., San Dimas, CA, 91773, USA.
Klausner JD; Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, 90089, USA.
Turner F; Curative Inc., San Dimas, CA, 91773, USA.
Slepnev VI; Curative Inc., San Dimas, CA, 91773, USA.
Ibrayeva A; Curative Inc., San Dimas, CA, 91773, USA. .; Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC, Department of Stem Cell Biology and Regenerative Medicine, W.M. Keck School of Medicine, Los Angeles, USA. .; Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA. .; Curative, Inc., 605 East Huntington Drive, Monrovia, CA, 91016, USA. .
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Źródło :
Scientific reports [Sci Rep] 2021 Dec 27; Vol. 11 (1), pp. 24448. Date of Electronic Publication: 2021 Dec 27.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibodies, Viral/*analysis
Immunoglobulin G/*analysis
Mouth Mucosa/*metabolism
Respiratory System/*metabolism
mRNA Vaccines/*immunology
Adult ; Aged ; COVID-19/prevention & control ; COVID-19/virology ; Female ; Health Personnel ; Humans ; Male ; Middle Aged ; SARS-CoV-2/immunology ; SARS-CoV-2/isolation & purification ; Time Factors ; Vaccination ; Young Adult ; mRNA Vaccines/administration & dosage
Czasopismo naukowe
Tytuł :
Long-term stability and protection efficacy of the RBD-targeting COVID-19 mRNA vaccine in nonhuman primates.
Autorzy :
Zhao H; State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, 100071, Beijing, China.
Wang TC; Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun, 130122, China.
Li XF; State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, 100071, Beijing, China.
Zhang NN; State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, 100071, Beijing, China.; School of Medicine, Tsinghua University, 100084, Beijing, China.
Li L; Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun, 130122, China.
Zhou C; State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, 100071, Beijing, China.
Deng YQ; State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, 100071, Beijing, China.
Cao TS; State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, 100071, Beijing, China.
Yang G; State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, 102206, Beijing, China.
Li RT; State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, 100071, Beijing, China.
Huang YJ; State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, 100071, Beijing, China.
Li YG; Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun, 130122, China.
Zhang YM; Shandong Normal University, Jinan, 250014, China.
Li FX; Shandong Normal University, Jinan, 250014, China.
Zhou YR; Suzhou Abogen Biosciences, Suzhou, 215123, China.
Jiang YH; Suzhou Abogen Biosciences, Suzhou, 215123, China.
Lu XS; Suzhou Abogen Biosciences, Suzhou, 215123, China.
Sun SH; State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, 100071, Beijing, China.
Cheng ML; State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, 100071, Beijing, China.
Gu KP; Suzhou Abogen Biosciences, Suzhou, 215123, China.
Zhang M; Suzhou Abogen Biosciences, Suzhou, 215123, China.
Ma QQ; State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, 100071, Beijing, China.
Yang X; State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, 102206, Beijing, China.
Ying B; Suzhou Abogen Biosciences, Suzhou, 215123, China. .
Gao YW; Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun, 130122, China. .
Qin CF; State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, 100071, Beijing, China. .; School of Medicine, Tsinghua University, 100084, Beijing, China. .; Research Unit of Discovery and Tracing of Natural Focus Diseases, Chinese Academy of Medical Sciences, 100071, Beijing, China. .
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Źródło :
Signal transduction and targeted therapy [Signal Transduct Target Ther] 2021 Dec 24; Vol. 6 (1), pp. 438. Date of Electronic Publication: 2021 Dec 24.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Immunogenicity, Vaccine*
COVID-19/*immunology
COVID-19 Vaccines/*pharmacology
SARS-CoV-2/*immunology
Spike Glycoprotein, Coronavirus/*immunology
mRNA Vaccines/*pharmacology
Animals ; Antibodies, Neutralizing/immunology ; Antibodies, Viral/immunology ; COVID-19/prevention & control ; COVID-19 Vaccines/immunology ; Chlorocebus aethiops ; Humans ; Macaca fascicularis ; Vero Cells ; mRNA Vaccines/immunology
Czasopismo naukowe
Tytuł :
High-Resolution Linear Epitope Mapping of the Receptor Binding Domain of SARS-CoV-2 Spike Protein in COVID-19 mRNA Vaccine Recipients.
Autorzy :
Nitahara Y; Department of Parasitology & Research Center for Infectious Disease Sciences, Graduate School of Medicine, Osaka City Universitygrid.261445.0, Osaka, Japan.
Nakagama Y; Department of Parasitology & Research Center for Infectious Disease Sciences, Graduate School of Medicine, Osaka City Universitygrid.261445.0, Osaka, Japan.
Kaku N; Department of Parasitology & Research Center for Infectious Disease Sciences, Graduate School of Medicine, Osaka City Universitygrid.261445.0, Osaka, Japan.
Candray K; Department of Parasitology & Research Center for Infectious Disease Sciences, Graduate School of Medicine, Osaka City Universitygrid.261445.0, Osaka, Japan.
Michimuko Y; Department of Parasitology & Research Center for Infectious Disease Sciences, Graduate School of Medicine, Osaka City Universitygrid.261445.0, Osaka, Japan.
Tshibangu-Kabamba E; Department of Parasitology & Research Center for Infectious Disease Sciences, Graduate School of Medicine, Osaka City Universitygrid.261445.0, Osaka, Japan.
Kaneko A; Department of Parasitology & Research Center for Infectious Disease Sciences, Graduate School of Medicine, Osaka City Universitygrid.261445.0, Osaka, Japan.
Yamamoto H; Department of Traumatology and Critical Care Medicine, Graduate School of Medicine, Osaka City Universitygrid.261445.0, Osaka, Japan.
Mizobata Y; Department of Traumatology and Critical Care Medicine, Graduate School of Medicine, Osaka City Universitygrid.261445.0, Osaka, Japan.
Kakeya H; Department of Infection Control Science, Graduate School of Medicine, Osaka City Universitygrid.261445.0, Osaka, Japan.
Yasugi M; Department of Veterinary Science, Graduate School of Life and Environmental Sciences, Osaka Prefecture Universitygrid.261455.1, Izumisano, Osaka, Japan.; Osaka International Research Center for Infectious Diseases, Osaka Prefecture Universitygrid.261455.1, Izumisano, Osaka, Japan.; Asian Health Science Research Institute, Osaka Prefecture Universitygrid.261455.1, Izumisano, Osaka, Japan.
Kido Y; Department of Parasitology & Research Center for Infectious Disease Sciences, Graduate School of Medicine, Osaka City Universitygrid.261445.0, Osaka, Japan.
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Źródło :
Microbiology spectrum [Microbiol Spectr] 2021 Dec 22; Vol. 9 (3), pp. e0096521. Date of Electronic Publication: 2021 Nov 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Epitope Mapping*
Protein Binding*
COVID-19/*immunology
COVID-19 Vaccines/*immunology
SARS-CoV-2/*immunology
Spike Glycoprotein, Coronavirus/*chemistry
mRNA Vaccines/*immunology
Antibodies, Neutralizing/immunology ; Antibodies, Viral/chemistry ; COVID-19/prevention & control ; COVID-19 Vaccines/chemistry ; Humans ; Spike Glycoprotein, Coronavirus/immunology ; Vaccination ; Vaccines, Synthetic/immunology ; mRNA Vaccines/chemistry
SCR Organism :
SARS-CoV-2 variants
Czasopismo naukowe
Tytuł :
Lipid nanoparticles enhance the efficacy of mRNA and protein subunit vaccines by inducing robust T follicular helper cell and humoral responses.
Autorzy :
Alameh MG; Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Tombácz I; Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Bettini E; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Lederer K; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Sittplangkoon C; Center of Excellence in Vaccine Research and Development, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Wilmore JR; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Gaudette BT; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Soliman OY; Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Pine M; Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Hicks P; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Manzoni TB; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Knox JJ; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Johnson JL; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Laczkó D; Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Muramatsu H; Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Davis B; Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Meng W; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Rosenfeld AM; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Strohmeier S; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Lin PJC; Acuitas Therapeutics, Vancouver, BC, Canada.
Mui BL; Acuitas Therapeutics, Vancouver, BC, Canada.
Tam YK; Acuitas Therapeutics, Vancouver, BC, Canada.
Karikó K; Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA; BioNTech RNA Pharmaceuticals, Mainz, Germany.
Jacquet A; Center of Excellence in Vaccine Research and Development, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Krammer F; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Bates P; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Cancro MP; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Weissman D; Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Luning Prak ET; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Allman D; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Locci M; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Electronic address: .
Pardi N; Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Electronic address: .
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Źródło :
Immunity [Immunity] 2021 Dec 14; Vol. 54 (12), pp. 2877-2892.e7. Date of Electronic Publication: 2021 Nov 04.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
B-Lymphocytes/*immunology
COVID-19/*immunology
COVID-19 Vaccines/*immunology
Germinal Center/*immunology
SARS-CoV-2/*physiology
T-Lymphocytes, Helper-Inducer/*immunology
mRNA Vaccines/*immunology
Adaptor Proteins, Signal Transducing/genetics ; Adaptor Proteins, Signal Transducing/metabolism ; Adjuvants, Immunologic ; Animals ; HEK293 Cells ; Humans ; Immunity, Humoral ; Interleukin-6/genetics ; Interleukin-6/metabolism ; Liposomes/administration & dosage ; Mice ; Mice, Inbred BALB C ; Nanoparticles/administration & dosage ; Protein Subunits/genetics ; mRNA Vaccines/genetics
Czasopismo naukowe
Tytuł :
Cellular variability of nonsense-mediated mRNA decay.
Autorzy :
Sato H; Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY, 10461, USA.
Singer RH; Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY, 10461, USA. .; Department of Cell Biology, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY, 10461, USA. .; Gruss Lipper Biophotonics Center, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY, 10461, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Dec 10; Vol. 12 (1), pp. 7203. Date of Electronic Publication: 2021 Dec 10.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Nonsense Mediated mRNA Decay*/genetics
RNA, Messenger/*metabolism
Codon, Nonsense ; Flow Cytometry ; Genes, Reporter/genetics ; HEK293 Cells ; Humans ; Phosphorylation ; Protein Serine-Threonine Kinases ; RNA Helicases ; Trans-Activators ; beta-Globins/genetics
Czasopismo naukowe
Tytuł :
Messenger RNA vaccines and neutralizing anti-severe acute respiratory syndrome coronavirus 2 antibodies in patients with immunodeficiency.
Autorzy :
Mungmunpuntipantip R; Private Academic Consultant Center, Bangkok, Thailand.
Wiwanitkit V; Department of Community Medicine, Dr DY Patil University, Pune, India. Electronic address: .
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Źródło :
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology [Ann Allergy Asthma Immunol] 2021 Dec; Vol. 127 (6), pp. 703.
Typ publikacji :
Letter
MeSH Terms :
Immunologic Deficiency Syndromes*
mRNA Vaccines*
COVID-19/*prevention & control
Antibodies, Viral ; COVID-19/epidemiology ; Humans ; Pandemics ; SARS-CoV-2
Opinia redakcyjna
Tytuł :
A role for AKT1 in nonsense-mediated mRNA decay.
Autorzy :
Palma M; Univ. Lille, CNRS, Inserm, CHU Lille, UMR9020-U1277 - CANTHER - Cancer Heterogeneity Plasticity and Resistance to Therapies, F-59000 Lille, France.; Unité tumorigenèse et résistance aux traitements, Institut Pasteur de Lille, F-59000 Lille, France.
Leroy C; Univ. Lille, CNRS, Inserm, CHU Lille, UMR9020-U1277 - CANTHER - Cancer Heterogeneity Plasticity and Resistance to Therapies, F-59000 Lille, France.; Unité tumorigenèse et résistance aux traitements, Institut Pasteur de Lille, F-59000 Lille, France.
Salomé-Desnoulez S; Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, US 41 - UMS 2014 - PLBS, F-59000 Lille, France.
Werkmeister E; Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, US 41 - UMS 2014 - PLBS, F-59000 Lille, France.; Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019 - UMR9017 - CIIL - center for Infection and Immunity of Lille, F-59000 Lille, France.
Kong R; Univ. Lille, CNRS, Inserm, CHU Lille, UMR9020-U1277 - CANTHER - Cancer Heterogeneity Plasticity and Resistance to Therapies, F-59000 Lille, France.; Unité tumorigenèse et résistance aux traitements, Institut Pasteur de Lille, F-59000 Lille, France.
Mongy M; Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, US 41 - UMS 2014 - PLBS, F-59000 Lille, France.
Le Hir H; Institut de Biologie de l'Ecole Normale Supérieure (IBENS), Ecole Normale Supérieure, CNRS, INSERM, PSL Research University, 46 rue d'Ulm, 75005 Paris, France.
Lejeune F; Univ. Lille, CNRS, Inserm, CHU Lille, UMR9020-U1277 - CANTHER - Cancer Heterogeneity Plasticity and Resistance to Therapies, F-59000 Lille, France.; Unité tumorigenèse et résistance aux traitements, Institut Pasteur de Lille, F-59000 Lille, France.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2021 Nov 08; Vol. 49 (19), pp. 11022-11037.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Codon, Nonsense*
Nonsense Mediated mRNA Decay*
Proto-Oncogene Proteins c-akt/*genetics
RNA Helicases/*genetics
RNA, Messenger/*genetics
RNA-Binding Proteins/*genetics
Trans-Activators/*genetics
Cell Proliferation ; Eukaryotic Initiation Factor-4E/genetics ; Eukaryotic Initiation Factor-4E/metabolism ; Gene Library ; Genes, Reporter ; HEK293 Cells ; HeLa Cells ; Humans ; Luciferases/genetics ; Luciferases/metabolism ; Phosphatidylinositol 3-Kinases/genetics ; Phosphatidylinositol 3-Kinases/metabolism ; Phosphorylation ; Proto-Oncogene Proteins c-akt/metabolism ; RNA Helicases/metabolism ; RNA, Messenger/metabolism ; RNA-Binding Proteins/metabolism ; Signal Transduction ; TOR Serine-Threonine Kinases/genetics ; TOR Serine-Threonine Kinases/metabolism ; Trans-Activators/metabolism
Czasopismo naukowe
Tytuł :
Molecular Approaches Fighting Nonsense.
Autorzy :
Pibiri I; Dipartimento di Scienze e Tecnologie Biologiche, Chimiche e Farmaceutiche-STEBICEF, Università degli Studi di Palermo, V.le delle Scienze Ed. 17, 90128 Palermo, Italy.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Nov 03; Vol. 22 (21). Date of Electronic Publication: 2021 Nov 03.
Typ publikacji :
Editorial
MeSH Terms :
Codon, Nonsense*
Mutation*
Nonsense Mediated mRNA Decay*
Protein Biosynthesis*
Genetic Diseases, Inborn/*therapy
Genetic Diseases, Inborn/genetics ; Genetic Diseases, Inborn/pathology ; Humans
Opinia redakcyjna

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