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Tytuł:
In Vitro Cross-Linking MS Reveals SMG1-UPF2-SMG7 Assembly as Molecular Partners within the NMD Surveillance.
Autorzy:
Padariya M; International Centre for Cancer Vaccine Science, University of Gdansk, ul. Kładki 24, 80-822 Gdansk, Poland.
Vojtesek B; Research Centre for Applied Molecular Oncology, Masaryk Memorial Cancer Institute, Zluty kopec 7, 656 53 Brno, Czech Republic.
Hupp T; International Centre for Cancer Vaccine Science, University of Gdansk, ul. Kładki 24, 80-822 Gdansk, Poland.; Edinburgh Cancer Research Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XR, UK.
Kalathiya U; International Centre for Cancer Vaccine Science, University of Gdansk, ul. Kładki 24, 80-822 Gdansk, Poland.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Mar 10; Vol. 25 (6). Date of Electronic Publication: 2024 Mar 10.
Typ publikacji:
Journal Article
MeSH Terms:
Nonsense Mediated mRNA Decay*
Codon, Nonsense*
Mutation ; RNA, Messenger/genetics ; Protein Structure, Secondary ; RNA Helicases/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Downregulation of CPSF6 leads to global mRNA 3' UTR shortening and enhanced antiviral immune responses.
Autorzy:
Ge Y; Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, MOE Key Laboratory of Gene Function and Regulation, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-Sen University, Guangzhou, China.; Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), Zhuhai, China.
Huang J; Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, MOE Key Laboratory of Gene Function and Regulation, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-Sen University, Guangzhou, China.; Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), Zhuhai, China.
Chen R; Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, MOE Key Laboratory of Gene Function and Regulation, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-Sen University, Guangzhou, China.; Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), Zhuhai, China.
Fu Y; Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, MOE Key Laboratory of Gene Function and Regulation, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-Sen University, Guangzhou, China.
Ling T; Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, MOE Key Laboratory of Gene Function and Regulation, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-Sen University, Guangzhou, China.; Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), Zhuhai, China.
Ou X; Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, MOE Key Laboratory of Gene Function and Regulation, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-Sen University, Guangzhou, China.
Rong X; Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, MOE Key Laboratory of Gene Function and Regulation, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-Sen University, Guangzhou, China.; Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), Zhuhai, China.
Cheng Y; Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, MOE Key Laboratory of Gene Function and Regulation, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-Sen University, Guangzhou, China.; Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), Zhuhai, China.
Lin Y; Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, MOE Key Laboratory of Gene Function and Regulation, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-Sen University, Guangzhou, China.; Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), Zhuhai, China.
Zhou F; Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, MOE Key Laboratory of Gene Function and Regulation, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-Sen University, Guangzhou, China.
Lu C; The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, China.; State Key Laboratory of Dampness Syndrome of Chinese Medicine, Guangdong-Hong Kong-Macau Joint Lab on Chinese Medicine and Immune Disease Research, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China.
Yuan S; Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, MOE Key Laboratory of Gene Function and Regulation, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-Sen University, Guangzhou, China.; Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), Zhuhai, China.
Xu A; Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, MOE Key Laboratory of Gene Function and Regulation, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-Sen University, Guangzhou, China.; School of Life Sciences, Beijing University of Chinese Medicine, Beijing, China.
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Źródło:
PLoS pathogens [PLoS Pathog] 2024 Feb 28; Vol. 20 (2), pp. e1012061. Date of Electronic Publication: 2024 Feb 28 (Print Publication: 2024).
Typ publikacji:
Journal Article
MeSH Terms:
mRNA Cleavage and Polyadenylation Factors*/genetics
mRNA Cleavage and Polyadenylation Factors*/metabolism
Polyadenylation*
Virus Diseases*/genetics
Humans ; 3' Untranslated Regions/genetics ; Down-Regulation ; Immunity/genetics ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Mice ; Animals
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Broad-spectrum Delta-BA.2 tandem-fused heterodimer mRNA vaccine delivered by lipopolyplex.
Autorzy:
Du P; CAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences (CAS), Beijing, China.
Huang L; Stemirna Therapeutics, Shanghai, China.
Fang Y; Stemirna Therapeutics, Shanghai, China.
Zhao F; Stemirna Therapeutics, Shanghai, China.
Li Q; Stemirna Therapeutics, Shanghai, China.
Ma X; CAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences (CAS), Beijing, China.
Li R; CAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences (CAS), Beijing, China.; Medical School, University of Chinese Academy of Sciences, Beijing, China.
Chen Q; CAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences (CAS), Beijing, China.; Faculty of Health Sciences, University of Macau, Macau, China.
Shen H; Stemirna Therapeutics, Shanghai, China.
Wang Q; CAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences (CAS), Beijing, China.; Medical School, University of Chinese Academy of Sciences, Beijing, China.; Faculty of Health Sciences, University of Macau, Macau, China.
Li H; Stemirna Therapeutics, Shanghai, China.
Gao GF; CAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences (CAS), Beijing, China.; Medical School, University of Chinese Academy of Sciences, Beijing, China.; Faculty of Health Sciences, University of Macau, Macau, China.
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Źródło:
PLoS pathogens [PLoS Pathog] 2024 Apr 01; Vol. 20 (4), pp. e1012116. Date of Electronic Publication: 2024 Apr 01 (Print Publication: 2024).
Typ publikacji:
Journal Article
MeSH Terms:
mRNA Vaccines*
COVID-19*/prevention & control
Animals ; Humans ; Mice ; COVID-19 Vaccines ; Macaca mulatta ; Immunization, Secondary ; Mice, Transgenic ; RNA, Messenger/genetics ; SARS-CoV-2/genetics ; Antibodies, Neutralizing ; Antibodies, Viral
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Engineering a Novel Modular Adenoviral mRNA Delivery Platform Based on Tag/Catcher Bioconjugation.
Autorzy:
Geng K; Department of Radiation Oncology, Biologic Therapeutics Center, Washington University School of Medicine, St. Louis, MO 63110, USA.; Department of Biomedical Engineering, McKelvey School of Engineering, Washington University in Saint Louis, St. Louis, MO 63130-4899, USA.
Rice-Boucher PJ; Department of Radiation Oncology, Biologic Therapeutics Center, Washington University School of Medicine, St. Louis, MO 63110, USA.; Department of Biomedical Engineering, McKelvey School of Engineering, Washington University in Saint Louis, St. Louis, MO 63130-4899, USA.
Kashentseva EA; Department of Radiation Oncology, Biologic Therapeutics Center, Washington University School of Medicine, St. Louis, MO 63110, USA.
Dmitriev IP; Department of Radiation Oncology, Biologic Therapeutics Center, Washington University School of Medicine, St. Louis, MO 63110, USA.
Lu ZH; Department of Radiation Oncology, Biologic Therapeutics Center, Washington University School of Medicine, St. Louis, MO 63110, USA.
Goedegebuure SP; Department of Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA.; Alvin J. Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine, St. Louis, MO 63110, USA.
Gillanders WE; Department of Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA.; Alvin J. Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine, St. Louis, MO 63110, USA.
Curiel DT; Department of Radiation Oncology, Biologic Therapeutics Center, Washington University School of Medicine, St. Louis, MO 63110, USA.; Department of Biomedical Engineering, McKelvey School of Engineering, Washington University in Saint Louis, St. Louis, MO 63130-4899, USA.
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Źródło:
Viruses [Viruses] 2023 Nov 20; Vol. 15 (11). Date of Electronic Publication: 2023 Nov 20.
Typ publikacji:
Journal Article
MeSH Terms:
Adenoviridae*/genetics
Genetic Vectors*/genetics
mRNA Vaccines*
CD4-Positive T-Lymphocytes ; CD8-Positive T-Lymphocytes ; Genetic Engineering
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
mRNA Vaccine Nanoplatforms and Innate Immunity.
Autorzy:
Wei L; Center for Inflammation, Immunity & Infection, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303, USA.
Dong C; Center for Inflammation, Immunity & Infection, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303, USA.
Zhu W; Center for Inflammation, Immunity & Infection, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303, USA.
Wang BZ; Center for Inflammation, Immunity & Infection, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303, USA.
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Źródło:
Viruses [Viruses] 2024 Jan 14; Vol. 16 (1). Date of Electronic Publication: 2024 Jan 14.
Typ publikacji:
Journal Article; Review
MeSH Terms:
mRNA Vaccines*
Pandemics*
Humans ; Immunity, Innate ; Adaptive Immunity ; RNA, Messenger/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
A Combinatorial Code for CPEB-Mediated c-myc Repression.
Autorzy:
Ogami K; Department of Biological Chemistry, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467-8603, Japan.; Division of Molecular Oncology, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan.
Ogawa K; Department of Biological Chemistry, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467-8603, Japan.
Sanpei S; Department of Biological Chemistry, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467-8603, Japan.
Ichikawa F; Department of Biological Chemistry, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467-8603, Japan.
Udagawa T; Department of Biological Chemistry, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467-8603, Japan.
Hoshino SI; Department of Biological Chemistry, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467-8603, Japan.
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Źródło:
Cells [Cells] 2023 Oct 06; Vol. 12 (19). Date of Electronic Publication: 2023 Oct 06.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
mRNA Cleavage and Polyadenylation Factors*/metabolism
Oocytes*/metabolism
RNA/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; RNA-Binding Proteins/metabolism ; Transcription Factors/metabolism ; Humans
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Timely Second-Dose Completion of mRNA COVID-19 Vaccination at Community-Based and Mobile Vaccine Clinics in Maryland.
Autorzy:
Parent C; Cassandra Parent, Benjamin F. Bigelow, Stephen D. Sisson, and Kathleen R. Page are with the Johns Hopkins University School of Medicine, Baltimore, MD. Diego Martínez is with the School of Industrial Engineering, Pontificia Universidad Católica de Valparaíso, Chile. Cui Yang is with Rutgers University School of Public Health, Newark, NJ.
Bigelow BF; Cassandra Parent, Benjamin F. Bigelow, Stephen D. Sisson, and Kathleen R. Page are with the Johns Hopkins University School of Medicine, Baltimore, MD. Diego Martínez is with the School of Industrial Engineering, Pontificia Universidad Católica de Valparaíso, Chile. Cui Yang is with Rutgers University School of Public Health, Newark, NJ.
Sisson SD; Cassandra Parent, Benjamin F. Bigelow, Stephen D. Sisson, and Kathleen R. Page are with the Johns Hopkins University School of Medicine, Baltimore, MD. Diego Martínez is with the School of Industrial Engineering, Pontificia Universidad Católica de Valparaíso, Chile. Cui Yang is with Rutgers University School of Public Health, Newark, NJ.
Martínez D; Cassandra Parent, Benjamin F. Bigelow, Stephen D. Sisson, and Kathleen R. Page are with the Johns Hopkins University School of Medicine, Baltimore, MD. Diego Martínez is with the School of Industrial Engineering, Pontificia Universidad Católica de Valparaíso, Chile. Cui Yang is with Rutgers University School of Public Health, Newark, NJ.
Yang C; Cassandra Parent, Benjamin F. Bigelow, Stephen D. Sisson, and Kathleen R. Page are with the Johns Hopkins University School of Medicine, Baltimore, MD. Diego Martínez is with the School of Industrial Engineering, Pontificia Universidad Católica de Valparaíso, Chile. Cui Yang is with Rutgers University School of Public Health, Newark, NJ.
Page KR; Cassandra Parent, Benjamin F. Bigelow, Stephen D. Sisson, and Kathleen R. Page are with the Johns Hopkins University School of Medicine, Baltimore, MD. Diego Martínez is with the School of Industrial Engineering, Pontificia Universidad Católica de Valparaíso, Chile. Cui Yang is with Rutgers University School of Public Health, Newark, NJ.
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Źródło:
American journal of public health [Am J Public Health] 2023 Sep; Vol. 113 (9), pp. 947-951. Date of Electronic Publication: 2023 Jul 06.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
COVID-19*/epidemiology
COVID-19*/prevention & control
COVID-19 Vaccines*/administration & dosage
COVID-19 Vaccines*/adverse effects
mRNA Vaccines*/administration & dosage
mRNA Vaccines*/adverse effects
Adolescent ; Adult ; Aged ; Female ; Humans ; Male ; Middle Aged ; Young Adult ; Community Health Centers ; Maryland/epidemiology ; Mobile Health Units ; Pandemics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Award honors pair for mRNA work key to COVID-19 vaccines.
Autorzy:
Offord C
Cohen J
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Źródło:
Science (New York, N.Y.) [Science] 2023 Oct 06; Vol. 382 (6666), pp. 22. Date of Electronic Publication: 2023 Oct 05.
Typ publikacji:
Wiadomości
MeSH Terms:
COVID-19*/prevention & control
COVID-19 Vaccines*
Nobel Prize*
mRNA Vaccines*
Humans ; Vaccination ; United States
Periodyk
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Mapping SARS-CoV-2 antigenic relationships and serological responses.
Autorzy:
Wilks SH; Center for Pathogen Evolution, Department of Zoology, University of Cambridge, Cambridge CB2 3EJ, UK.
Mühlemann B; Institute of Virology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany.; German Centre for Infection Research (DZIF), partner site Charité, 10117 Berlin, Germany.
Shen X; Department of Surgery, Duke University School of Medicine, Durham, NC, USA.; Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC, USA.
Türeli S; Center for Pathogen Evolution, Department of Zoology, University of Cambridge, Cambridge CB2 3EJ, UK.
LeGresley EB; Center for Pathogen Evolution, Department of Zoology, University of Cambridge, Cambridge CB2 3EJ, UK.
Netzl A; Center for Pathogen Evolution, Department of Zoology, University of Cambridge, Cambridge CB2 3EJ, UK.
Caniza MA; Department of Global Pediatric Medicine, Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN, USA.
Chacaltana-Huarcaya JN; Hospital Nacional Daniel A. Carrión, Callao, Bellavista, Peru.
Corman VM; Institute of Virology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany.; German Centre for Infection Research (DZIF), partner site Charité, 10117 Berlin, Germany.
Daniell X; Department of Surgery, Duke University School of Medicine, Durham, NC, USA.
Datto MB; Department of Pathology, Duke University School of Medicine, Durham, NC, USA.
Dawood FS; Centers for Disease Control and Prevention, Atlanta, GA, USA.
Denny TN; Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC, USA.
Drosten C; Institute of Virology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany.; German Centre for Infection Research (DZIF), partner site Charité, 10117 Berlin, Germany.
Fouchier RAM; Erasmus Medical Center, Rotterdam, Netherlands.
Garcia PJ; School of Public Health, Universidad Peruana Cayetano Heredia, Lima, Peru.
Halfmann PJ; Influenza Research Institute, Department of Pathobiological Science, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI, USA.
Jassem A; BC Centre for Disease Control, Vancouver, British Columbia, Canada.
Jeworowski LM; Institute of Virology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany.
Jones TC; Center for Pathogen Evolution, Department of Zoology, University of Cambridge, Cambridge CB2 3EJ, UK.; Institute of Virology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany.; German Centre for Infection Research (DZIF), partner site Charité, 10117 Berlin, Germany.
Kawaoka Y; Influenza Research Institute, Department of Pathobiological Science, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI, USA.; Division of Virology, Institute of Medical Science, University of Tokyo, Tokyo, Japan.; The Research Center for Global Viral Diseases, National Center for Global Health and Medicine Research Institute, Tokyo, Japan.; Pandemic Preparedness, Infection and Advanced Research Center (UTOPIA), University of Tokyo, Tokyo, Japan.
Krammer F; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Pathology, Cellular and Molecular Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
McDanal C; Department of Surgery, Duke University School of Medicine, Durham, NC, USA.
Pajon R; Moderna, Inc., Cambridge, MA, USA.
Simon V; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Pathology, Cellular and Molecular Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Global Health and Emerging Pathogen Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Stockwell MS; Division of Child and Adolescent Health, Department of Pediatrics, Columbia University Vagelos College of Physicians and Surgeons, and Department of Population and Family Health, Mailman School of Public Health, New York, NY, USA.
Tang H; Department of Surgery, Duke University School of Medicine, Durham, NC, USA.
van Bakel H; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Veguilla V; Centers for Disease Control and Prevention, Atlanta, GA, USA.
Webby R; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN, USA.
Montefiori DC; Department of Surgery, Duke University School of Medicine, Durham, NC, USA.; Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC, USA.
Smith DJ; Center for Pathogen Evolution, Department of Zoology, University of Cambridge, Cambridge CB2 3EJ, UK.
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Źródło:
Science (New York, N.Y.) [Science] 2023 Oct 06; Vol. 382 (6666), pp. eadj0070. Date of Electronic Publication: 2023 Oct 06.
Typ publikacji:
Journal Article
MeSH Terms:
COVID-19*
SARS-CoV-2*/genetics
SARS-CoV-2*/immunology
Spike Glycoprotein, Coronavirus*/genetics
Spike Glycoprotein, Coronavirus*/immunology
Antigens, Viral*/genetics
Antigens, Viral*/immunology
mRNA Vaccines*/immunology
Humans ; Antibodies, Neutralizing/blood ; Antibodies, Neutralizing/immunology ; Antibodies, Viral/blood ; Antibodies, Viral/immunology ; Cross Reactions ; Vaccination ; Amino Acid Substitution
SCR Organism:
SARS-CoV-2 variants
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
A Cocktail of Lipid Nanoparticle-mRNA Vaccines Broaden Immune Responses against β-Coronaviruses in a Murine Model.
Autorzy:
Zhang Y; Division of Hepatitis and Enterovirus Vaccines, Institute of Biological Products, National Institutes for Food and Drug Control, NHC Key Laboratory of Research on Quality and Standardization of Biotech Products, NMPA Key Laboratory for Quality Research and Evaluation of Biological Products, State Key Laboratory of Drug Regulatory Science, Beijing 102629, China.; Shanghai Biological Products Research Institute Co., Ltd., State Key Laboratory of Novel Vaccines for Emerging Infectious Diseases, Shanghai 200052, China.
Zhang J; Division of Hepatitis and Enterovirus Vaccines, Institute of Biological Products, National Institutes for Food and Drug Control, NHC Key Laboratory of Research on Quality and Standardization of Biotech Products, NMPA Key Laboratory for Quality Research and Evaluation of Biological Products, State Key Laboratory of Drug Regulatory Science, Beijing 102629, China.; National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun 130012, China.
Li D; Shanghai Biological Products Research Institute Co., Ltd., State Key Laboratory of Novel Vaccines for Emerging Infectious Diseases, Shanghai 200052, China.
Mao Q; Division of Hepatitis and Enterovirus Vaccines, Institute of Biological Products, National Institutes for Food and Drug Control, NHC Key Laboratory of Research on Quality and Standardization of Biotech Products, NMPA Key Laboratory for Quality Research and Evaluation of Biological Products, State Key Laboratory of Drug Regulatory Science, Beijing 102629, China.
Li X; Shanghai Biological Products Research Institute Co., Ltd., State Key Laboratory of Novel Vaccines for Emerging Infectious Diseases, Shanghai 200052, China.
Liang Z; Division of Hepatitis and Enterovirus Vaccines, Institute of Biological Products, National Institutes for Food and Drug Control, NHC Key Laboratory of Research on Quality and Standardization of Biotech Products, NMPA Key Laboratory for Quality Research and Evaluation of Biological Products, State Key Laboratory of Drug Regulatory Science, Beijing 102629, China.
He Q; Division of Hepatitis and Enterovirus Vaccines, Institute of Biological Products, National Institutes for Food and Drug Control, NHC Key Laboratory of Research on Quality and Standardization of Biotech Products, NMPA Key Laboratory for Quality Research and Evaluation of Biological Products, State Key Laboratory of Drug Regulatory Science, Beijing 102629, China.
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Źródło:
Viruses [Viruses] 2024 Mar 21; Vol. 16 (3). Date of Electronic Publication: 2024 Mar 21.
Typ publikacji:
Journal Article
MeSH Terms:
Viral Vaccines*/genetics
Severe acute respiratory syndrome-related coronavirus*/genetics
Liposomes*
Nanoparticles*
Animals ; Mice ; Humans ; mRNA Vaccines ; SARS-CoV-2/genetics ; COVID-19 Vaccines ; Spike Glycoprotein, Coronavirus/genetics ; Disease Models, Animal ; Antibodies, Neutralizing ; RNA, Messenger/genetics ; Immunity ; Antibodies, Viral
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
An overview on mRNA-based vaccines to prevent monkeypox infection.
Autorzy:
Natami M; Department of Urology, Shahid Mohammadi Hospital, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
Gorgzadeh A; Faculty of Pharmacy, Jondi Shapour University, Ahvaz, Iran.
Gholipour A; Free Researchers, Biotechnology and Nanobiotechnology, Babolsar, Iran.
Fatemi SN; Faculty of Veterinary, University of Tehran, Tehran, Iran.
Firouzeh N; Vector-borne Diseases Research Center, North Khorasan University of Medical Sciences, Bojnurd, Iran.
Zokaei M; Department of Food Science and Technology, Faculty of Nutrition Science, Food Science and Technology/National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Mohammed Ali SH; College of Dentistry, Al-Mustaqbal University, Babylon, 51001, Iraq.
Kheradjoo H; Laboratory Department, Buraimi Hospital, Buraimi, Oman.
Sedighi S; Medical Science of Mashhad, Mashhad, Iran.
Gholizadeh O; AZAD Researchers, Viro & biotche, Tehran, Iran. .
Kalavi S; Department of Clinical Pharmacy, Faculty of Pharmacy, Islamic Azad University of Medical Sciences, Tehran, Iran. .
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Źródło:
Journal of nanobiotechnology [J Nanobiotechnology] 2024 Mar 01; Vol. 22 (1), pp. 86. Date of Electronic Publication: 2024 Mar 01.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Smallpox Vaccine*
Smallpox*
Mpox (monkeypox)*/prevention & control
United States ; Humans ; mRNA Vaccines ; COVID-19 Vaccines ; Antigens, Viral
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
A mRNA Vaccine for Crimean-Congo Hemorrhagic Fever Virus Expressing Non-Fusion GnGc Using NSm Linker Elicits Unexpected Immune Responses in Mice.
Autorzy:
Chen T; Viral Hemorrhagic Fever Research Unit, Chinese Academy of Sciences (CAS) Key Laboratory of Molecular Virology & Immunology, Shanghai Institute of Immunity and Infection (Formerly Institut Pasteur of Shanghai), Chinese Academy of Sciences, Shanghai 200031, China.; University of Chinese Academy of Sciences, Beijing 100049, China.
Ding Z; Viral Hemorrhagic Fever Research Unit, Chinese Academy of Sciences (CAS) Key Laboratory of Molecular Virology & Immunology, Shanghai Institute of Immunity and Infection (Formerly Institut Pasteur of Shanghai), Chinese Academy of Sciences, Shanghai 200031, China.; University of Chinese Academy of Sciences, Beijing 100049, China.
Li X; Viral Hemorrhagic Fever Research Unit, Chinese Academy of Sciences (CAS) Key Laboratory of Molecular Virology & Immunology, Shanghai Institute of Immunity and Infection (Formerly Institut Pasteur of Shanghai), Chinese Academy of Sciences, Shanghai 200031, China.; University of Chinese Academy of Sciences, Beijing 100049, China.
Li Y; Viral Hemorrhagic Fever Research Unit, Chinese Academy of Sciences (CAS) Key Laboratory of Molecular Virology & Immunology, Shanghai Institute of Immunity and Infection (Formerly Institut Pasteur of Shanghai), Chinese Academy of Sciences, Shanghai 200031, China.; University of Chinese Academy of Sciences, Beijing 100049, China.
Lan J; Viral Hemorrhagic Fever Research Unit, Chinese Academy of Sciences (CAS) Key Laboratory of Molecular Virology & Immunology, Shanghai Institute of Immunity and Infection (Formerly Institut Pasteur of Shanghai), Chinese Academy of Sciences, Shanghai 200031, China.
Wong G; Viral Hemorrhagic Fever Research Unit, Chinese Academy of Sciences (CAS) Key Laboratory of Molecular Virology & Immunology, Shanghai Institute of Immunity and Infection (Formerly Institut Pasteur of Shanghai), Chinese Academy of Sciences, Shanghai 200031, China.
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Źródło:
Viruses [Viruses] 2024 Feb 28; Vol. 16 (3). Date of Electronic Publication: 2024 Feb 28.
Typ publikacji:
Journal Article
MeSH Terms:
Hemorrhagic Fever Virus, Crimean-Congo*
Hemorrhagic Fever, Crimean*
Humans ; Animals ; Mice ; mRNA Vaccines ; Vaccination ; Immunity, Cellular
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Initial Efficacy of the COVID-19 mRNA Vaccine Booster and Subsequent Breakthrough Omicron Variant Infection in Patients with B-Cell Non-Hodgkin's Lymphoma: A Single-Center Cohort Study.
Autorzy:
Saito M; Blood Disorders Center, Aiiku Hospital, Sapporo 064-0804, Hokkaido, Japan.
Mori A; Blood Disorders Center, Aiiku Hospital, Sapporo 064-0804, Hokkaido, Japan.
Ishio T; Blood Disorders Center, Aiiku Hospital, Sapporo 064-0804, Hokkaido, Japan.
Kobayashi M; Blood Disorders Center, Aiiku Hospital, Sapporo 064-0804, Hokkaido, Japan.
Tsukamoto S; Blood Disorders Center, Aiiku Hospital, Sapporo 064-0804, Hokkaido, Japan.
Kajikawa S; Blood Disorders Center, Aiiku Hospital, Sapporo 064-0804, Hokkaido, Japan.
Yokoyama E; Blood Disorders Center, Aiiku Hospital, Sapporo 064-0804, Hokkaido, Japan.
Kanaya M; Blood Disorders Center, Aiiku Hospital, Sapporo 064-0804, Hokkaido, Japan.
Izumiyama K; Blood Disorders Center, Aiiku Hospital, Sapporo 064-0804, Hokkaido, Japan.
Muraki H; Division of Laboratory, Aiiku Hospital, Sapporo 064-0804, Hokkaido, Japan.
Morioka M; Blood Disorders Center, Aiiku Hospital, Sapporo 064-0804, Hokkaido, Japan.
Kondo T; Blood Disorders Center, Aiiku Hospital, Sapporo 064-0804, Hokkaido, Japan.
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Źródło:
Viruses [Viruses] 2024 Feb 21; Vol. 16 (3). Date of Electronic Publication: 2024 Feb 21.
Typ publikacji:
Journal Article
MeSH Terms:
COVID-19*/prevention & control
Lymphoma*
Lymphoma, Non-Hodgkin*/drug therapy
Humans ; COVID-19 Vaccines ; mRNA Vaccines ; Breakthrough Infections ; Cohort Studies ; SARS-CoV-2/genetics ; RNA, Messenger ; Vaccination ; Antibodies, Viral
SCR Organism:
SARS-CoV-2 variants
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Molecular Interaction of Nonsense-Mediated mRNA Decay with Viruses.
Autorzy:
Ahmed MR; College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou 310018, China.
Du Z; College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou 310018, China.
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Źródło:
Viruses [Viruses] 2023 Mar 23; Vol. 15 (4). Date of Electronic Publication: 2023 Mar 23.
Typ publikacji:
Journal Article; Review; Research Support, Non-U.S. Gov't
MeSH Terms:
Nonsense Mediated mRNA Decay*
RNA Viruses*/genetics
Protein Biosynthesis ; Codon, Terminator ; Antiviral Agents
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Massive RNA sequencing effort proposed.
Autorzy:
Pennisi E
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Źródło:
Science (New York, N.Y.) [Science] 2024 Mar 29; Vol. 383 (6690), pp. 1398. Date of Electronic Publication: 2024 Mar 28.
Typ publikacji:
Wiadomości
MeSH Terms:
Sequence Analysis, RNA*/economics
RNA*/genetics
RNA*/metabolism
Capital Financing*
Human Genome Project/economics ; United States ; Humans ; mRNA Vaccines/genetics ; Disease
Periodyk
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
In silico designed novel multi-epitope mRNA vaccines against Brucella by targeting extracellular protein BtuB and LptD.
Autorzy:
Shi J; Department of Clinical Laboratory, The First Affiliated Hospital of Xinjiang Medical University, No. 393, Xinyi Road, Urumqi, 830011, Xinjiang, China.
Zhu Y; Department of Reproductive Assistance, Center forReproductive Medicine, The First Affiliated Hospital of Xinjiang Medical University, No. 393, Xinyi Road, Urumqi, 830011, Xinjiang, China.
Yin Z; Department of Clinical Laboratory, The First Affiliated Hospital of Xinjiang Medical University, No. 393, Xinyi Road, Urumqi, 830011, Xinjiang, China.
He Y; Department of Immunology, School of Basic Medical Sciences, Xinjiang Medical University, No. 393, Xinyi Road, Urumqi, 830011, Xinjiang, China.
Li Y; Department of Blood Transfusion, First Affiliated Hospital of Xinjiang Medical University, No. 393, Xinyi Road, Urumqi, 830011, Xinjiang, China.
Haimiti G; Department of Clinical Laboratory, The First Affiliated Hospital of Xinjiang Medical University, No. 393, Xinyi Road, Urumqi, 830011, Xinjiang, China.
Xie X; Department of Clinical Laboratory, The First Affiliated Hospital of Xinjiang Medical University, No. 393, Xinyi Road, Urumqi, 830011, Xinjiang, China.
Niu C; Department of Clinical Laboratory, The First Affiliated Hospital of Xinjiang Medical University, No. 393, Xinyi Road, Urumqi, 830011, Xinjiang, China.
Guo W; Department of Clinical Laboratory, The First Affiliated Hospital of Xinjiang Medical University, No. 393, Xinyi Road, Urumqi, 830011, Xinjiang, China.
Zhang F; State Key Laboratory of Pathogenesis, Prevention, Treatment of Central Asian High Incidence Diseases, the First Affiliated Hospital of Xinjiang Medical University, No. 393, Xinyi Road, Urumqi, 830011, China. .
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Źródło:
Scientific reports [Sci Rep] 2024 Mar 27; Vol. 14 (1), pp. 7278. Date of Electronic Publication: 2024 Mar 27.
Typ publikacji:
Journal Article
MeSH Terms:
Brucella*/genetics
Vaccines*
Escherichia coli Proteins*
Humans ; mRNA Vaccines ; Escherichia coli ; Lipopolysaccharides ; Epitopes, T-Lymphocyte ; Epitopes, B-Lymphocyte ; T-Lymphocytes, Cytotoxic ; Molecular Dynamics Simulation ; Vaccines, Subunit ; Computational Biology ; Molecular Docking Simulation ; Bacterial Outer Membrane Proteins/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Genetic screens in Saccharomyces cerevisiae identify a role for 40S ribosome recycling factors Tma20 and Tma22 in nonsense-mediated decay.
Autorzy:
Pacheco M; Department of Molecular Biology and Genetics, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
D'Orazio KN; Department of Molecular Biology and Genetics, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Lessen LN; Department of Molecular Biology and Genetics, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Veltri AJ; Department of Molecular Biology and Genetics, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Neiman Z; Department of Molecular Biology and Genetics, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Loll-Krippleber R; Department of Biochemistry and Donnelly Centre, University of Toronto, Toronto, ON M5S 3E1, Canada.
Brown GW; Department of Biochemistry and Donnelly Centre, University of Toronto, Toronto, ON M5S 3E1, Canada.
Green R; Department of Molecular Biology and Genetics, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
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Źródło:
G3 (Bethesda, Md.) [G3 (Bethesda)] 2024 Mar 06; Vol. 14 (3).
Typ publikacji:
Journal Article
MeSH Terms:
Saccharomyces cerevisiae*/genetics
Saccharomyces cerevisiae*/metabolism
RNA Helicases*/metabolism
Animals ; Nonsense Mediated mRNA Decay ; Ribosomes/genetics ; Ribosomes/metabolism ; RNA, Messenger/genetics ; Mammals/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Comparable safety and non-inferior immunogenicity of the SARS-CoV-2 mRNA vaccine candidate PTX-COVID19-B and BNT162b2 in a phase 2 randomized, observer-blinded study.
Autorzy:
Reiter L; Providence Therapeutics Holdings Inc., 120-8832 Blackfoot Trail SE, Calgary, AB, T2J 3J1, Canada.
Greffrath J; South African Medical Research Council Vaccines and Infectious Diseases Analytics Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Zidel B; Malton Medical Center, 6870 Goreway Dr., Mississauga, ON, L4V 1P1, Canada.
Ostrowski M; Department of Medicine, Immunology, University of Toronto, Medical Sciences Building, Rm 6271. 1 King's College Circle, Toronto, ON, M5S 1A8, Canada.
Gommerman J; Department of Immunology, Temerty Faculty of Medicine, 1 King's College Circle, Rm. 7233, Toronto, ON, M5S 1A8, Canada.
Madhi SA; South African Medical Research Council Vaccines and Infectious Diseases Analytics Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Tran R; Providence Therapeutics Holdings Inc., 120-8832 Blackfoot Trail SE, Calgary, AB, T2J 3J1, Canada.
Martin-Orozco N; Providence Therapeutics Holdings Inc., 120-8832 Blackfoot Trail SE, Calgary, AB, T2J 3J1, Canada.
Panicker RKG; Providence Therapeutics Holdings Inc., 120-8832 Blackfoot Trail SE, Calgary, AB, T2J 3J1, Canada.
Cooper C; The Ottawa Hospital Viral Hepatitis Program, Division of Infectious Diseases, Department of Medicine, The Ottawa Hospital, University of Ottawa, 75 Laurier Ave. East, Ottawa, ON, K1N 6N5, Canada.
Pastrak A; Providence Therapeutics Holdings Inc., 120-8832 Blackfoot Trail SE, Calgary, AB, T2J 3J1, Canada. .
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Źródło:
Scientific reports [Sci Rep] 2024 Mar 04; Vol. 14 (1), pp. 5365. Date of Electronic Publication: 2024 Mar 04.
Typ publikacji:
Clinical Trial, Phase II; Journal Article; Randomized Controlled Trial
MeSH Terms:
COVID-19*/prevention & control
COVID-19 Vaccines*/adverse effects
Adult ; Humans ; Antibodies, Neutralizing ; BNT162 Vaccine ; CD59 Antigens ; mRNA Vaccines ; Pandemics ; SARS-CoV-2
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Comparative efficacy and safety of COVID-19 vaccines in phase III trials: a network meta-analysis.
Autorzy:
Wu X; Medical School of Nanjing University, Nanjing, 210000, China.
Xu K; Medical School of Nanjing University, Nanjing, 210000, China.
Zhan P; Department of Respiratory and Critical Care Medicine, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, 210000, China.
Liu H; Department of Respiratory and Critical Care Medicine, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, 210000, China.
Zhang F; Department of Respiratory and Critical Care Medicine, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, 210000, China.
Song Y; Medical School of Nanjing University, Nanjing, 210000, China. .; Department of Respiratory and Critical Care Medicine, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, 210000, China. .
Lv T; Medical School of Nanjing University, Nanjing, 210000, China. .; Department of Respiratory and Critical Care Medicine, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, 210000, China. .
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Źródło:
BMC infectious diseases [BMC Infect Dis] 2024 Feb 21; Vol. 24 (1), pp. 234. Date of Electronic Publication: 2024 Feb 21.
Typ publikacji:
Meta-Analysis; Review; Journal Article
MeSH Terms:
COVID-19*/prevention & control
Vaccines*
Adult ; Humans ; Aged ; mRNA Vaccines ; Network Meta-Analysis ; BNT162 Vaccine ; SARS-CoV-2 ; COVID-19 Vaccines/adverse effects ; Clinical Trials, Phase III as Topic
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Wyświetlanie 1-20 z 51515

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